PedAM

Pediatric Disease Annotations & Medicines


	testicular cancer

Disease ID	452
Disease	testicular cancer
Definition	Testicles, or testes, make male hormones and sperm. They are two egg-shaped organs inside the scrotum, the loose sac of skin behind the penis. You can get cancer in one or both testicles. Testicular cancer mainly affects young men between the ages of 20 and 39. It is also more common in men who Have had abnormal testicle development Have had an undescended testicle Have a family history of the cancer Symptoms include pain, swelling, or lumps in your testicles or groin area. Doctors use a physical exam, lab tests, imaging tests, and a biopsy to diagnose testicular cancer. Most cases can be treated, especially if found early. Treatment options include surgery, radiation, and/or chemotherapy. Regular exams after treatment are important. Treatments may also cause infertility. If you may want children later on, you should consider sperm banking before treatment. NIH: National Cancer Institute
Synonym	cancer of testis cancer of the testes cancer of the testis cancer testicle cancer testicles cancer testicular cancer testis cancer, testicular cancer, testis cancers, testicular cancers, testis malignant neoplasm of testis malignant neoplasm of testis nos malignant neoplasm of testis nos (disorder) malignant neoplasm of testis, nos malignant neoplasm of the testis malignant testicular neoplasm malignant testicular tumor malignant tumor of testis malignant tumor of testis (disorder) malignant tumor of the testis malignant tumour of testis testicle cancer testicular cancers testis cancer testis cancers testis neoplasm malignant testis--cancer
DOID	DOID:2998
UMLS	C0153594
SNOMED-CT	SNOMEDCT_US_2016_09_01:363449006
Comorbidity	UMLS \| Disease \| Sentences' Count(Total Sentences:29) C0021359 \| infertility \| 4 C0040053 \| thrombus \| 2 C0242350 \| erectile dysfunction \| 2 C0011633 \| dermatomyositis \| 2 C0036341 \| schizophrenia \| 2 C0376358 \| prostate cancer \| 2 C0036202 \| sarcoidosis \| 2 C0011570 \| depression \| 2 C0686619 \| lymph node metastases \| 1 C0014859 \| esophageal cancer \| 1 C0033953 \| sexual dysfunction \| 1 C0033038 \| premature ejaculation \| 1 C0264716 \| chronic heart failure \| 1 C0018801 \| heart failure \| 1 C0003467 \| anxiety \| 1 C0035078 \| renal failure \| 1 C0018995 \| hemochromatosis \| 1 C0007222 \| cardiovascular disease \| 1 C0153676 \| lung metastases \| 1 C0040053 \| thrombosis \| 1 C0042373 \| vascular disease \| 1 C0085655 \| polymyositis \| 1 C0024299 \| lymphomas \| 1 C0021359 \| infertile \| 1 C0004509 \| azoospermia \| 1 C0036631 \| seminoma \| 1 C0022660 \| acute renal failure \| 1 C0037856 \| testicular torsion \| 1 C0004030 \| aspergillosis \| 1
Curated Gene	Entrez_id \| Symbol \| Resource(Total Genes:5) KIT \| 3815 \| CLINVAR STK11 \| 6794 \| CLINVAR DMRT1 \| 1761 \| GWASCAT BCL10 \| 8915 \| CLINVAR KITLG \| 4254 \| GWASCAT
Inferring Gene	Entrez_id \| Symbol \| Resource(Total Genes:18) 367 \| AR \| infer 8915 \| BCL10 \| infer 1544 \| CYP1A2 \| infer 1545 \| CYP1B1 \| infer 1576 \| CYP3A4 \| infer 1577 \| CYP3A5 \| infer 2067 \| ERCC1 \| infer 2068 \| ERCC2 \| infer 3119 \| HLA-DQB1 \| infer 3123 \| HLA-DRB1 \| infer 3460 \| IFNGR2 \| infer 3586 \| IL10 \| infer 4254 \| KITLG \| infer 4049 \| LTA \| infer 10743 \| RAI1 \| infer 5970 \| RELA \| infer 7040 \| TGFB1 \| infer 7124 \| TNF \| infer
Text Mined Gene	Entrez_id \| Symbol \| Score \| Resource(Total Genes:315) 56603 \| CYP26B1 \| DISEASES 10942 \| PRSS21 \| DISEASES 43847 \| KLK14 \| DISEASES 2249 \| FGF4 \| DISEASES 8839 \| WISP2 \| DISEASES 51314 \| NME8 \| DISEASES 7022 \| TFAP2C \| DISEASES 2099 \| ESR1 \| DISEASES 25807 \| RHBDD3 \| DISEASES 57167 \| SALL4 \| DISEASES 412 \| STS \| DISEASES 9057 \| SLC7A6 \| DISEASES 2765 \| GML \| DISEASES 268 \| AMH \| DISEASES 1048 \| CEACAM5 \| DISEASES 5054 \| SERPINE1 \| DISEASES 6013 \| RLN1 \| DISEASES 1440 \| CSF3 \| DISEASES 3216 \| HOXB6 \| DISEASES 4254 \| KITLG \| DISEASES 6404 \| SELPLG \| DISEASES 2026 \| ENO2 \| DISEASES 339 \| APOBEC1 \| DISEASES 79923 \| NANOG \| DISEASES 3945 \| LDHB \| DISEASES 604 \| BCL6 \| DISEASES 5948 \| RBP2 \| DISEASES 79084 \| WDR77 \| DISEASES 23169 \| SLC35D1 \| DISEASES 3215 \| HOXB5 \| DISEASES 3624 \| INHBA \| DISEASES 3623 \| INHA \| DISEASES 3007 \| HIST1H1D \| DISEASES 9271 \| PIWIL1 \| DISEASES 6662 \| SOX9 \| DISEASES 30848 \| CTAG2 \| DISEASES 22933 \| SIRT2 \| DISEASES 8930 \| MBD4 \| DISEASES 1618 \| DAZL \| DISEASES 79977 \| GRHL2 \| DISEASES 56165 \| TDRD1 \| DISEASES 3852 \| KRT5 \| DISEASES 83639 \| TEX101 \| DISEASES 10462 \| CLEC10A \| DISEASES 1401 \| CRP \| DISEASES 10955 \| SERINC3 \| DISEASES 10468 \| FST \| DISEASES 81494 \| CFHR5 \| DISEASES 4677 \| NARS \| DISEASES 269 \| AMHR2 \| DISEASES 1593 \| CYP27A1 \| DISEASES 5460 \| POU5F1 \| DISEASES 1588 \| CYP19A1 \| DISEASES 55729 \| ATF7IP \| DISEASES 894 \| CCND2 \| DISEASES 642 \| BLMH \| DISEASES 25939 \| SAMHD1 \| DISEASES 57148 \| RALGAPB \| DISEASES 6855 \| SYP \| DISEASES 9424 \| KCNK6 \| DISEASES 4058 \| LTK \| DISEASES 943 \| TNFRSF8 \| DISEASES 9262 \| STK17B \| DISEASES 51192 \| CKLF \| DISEASES 3299 \| HSF4 \| DISEASES 119 \| ADD2 \| DISEASES 1788 \| DNMT3A \| DISEASES 10180 \| RBM6 \| DISEASES 4704 \| NDUFA9 \| DISEASES 9746 \| CLSTN3 \| DISEASES 939 \| CD27 \| DISEASES 83729 \| INHBE \| DISEASES 1583 \| CYP11A1 \| DISEASES 92017 \| SNX29 \| DISEASES 54957 \| TXNL4B \| DISEASES 1213 \| CLTC \| DISEASES 7157 \| TP53 \| DISEASES 29947 \| DNMT3L \| DISEASES 93650 \| ACPT \| DISEASES 148327 \| CREB3L4 \| DISEASES 10699 \| CORIN \| DISEASES 890 \| CCNA2 \| DISEASES 255626 \| HIST1H2BA \| DISEASES 346673 \| STRA8 \| DISEASES 4103 \| MAGEA4 \| DISEASES 2796 \| GNRH1 \| DISEASES 63978 \| PRDM14 \| DISEASES 57689 \| LRRC4C \| DISEASES 498 \| ATP5A1 \| DISEASES 2697 \| GJA1 \| DISEASES 3206 \| HOXA10 \| DISEASES 50940 \| PDE11A \| DISEASES 27163 \| NAAA \| DISEASES 392255 \| GDF6 \| DISEASES 3815 \| KIT \| DISEASES 56896 \| DPYSL5 \| DISEASES 10120 \| ACTR1B \| DISEASES 11309 \| SLCO2B1 \| DISEASES 3460 \| IFNGR2 \| DISEASES 10642 \| IGF2BP1 \| DISEASES 92304 \| SCGB3A1 \| DISEASES 3973 \| LHCGR \| DISEASES 3625 \| INHBB \| DISEASES 27306 \| HPGDS \| DISEASES 251 \| ALPPL2 \| DISEASES 248 \| ALPI \| DISEASES 152185 \| SPICE1 \| DISEASES 6997 \| TDGF1 \| DISEASES 3015 \| H2AFZ \| DISEASES 9607 \| CARTPT \| DISEASES 3562 \| IL3 \| DISEASES 1437 \| CSF2 \| DISEASES 85477 \| SCIN \| DISEASES 9833 \| MELK \| DISEASES 122042 \| RXFP2 \| DISEASES 4108 \| MAGEA9 \| DISEASES 143689 \| PIWIL4 \| DISEASES 27343 \| POLL \| DISEASES 2923 \| PDIA3 \| DISEASES 3816 \| KLK1 \| DISEASES 4255 \| MGMT \| DISEASES 5617 \| PRL \| DISEASES 9085 \| CDY1 \| DISEASES 253175 \| CDY1B \| DISEASES 86614 \| HSFY1 \| DISEASES 3171 \| FOXA3 \| DISEASES 84203 \| TXNDC2 \| DISEASES 159119 \| HSFY2 \| DISEASES 794 \| CALB2 \| DISEASES 2147 \| F2 \| DISEASES 3626 \| INHBC \| DISEASES 55695 \| NSUN5 \| DISEASES 7015 \| TERT \| DISEASES 947 \| CD34 \| DISEASES 5619 \| PRM1 \| DISEASES 836 \| CASP3 \| DISEASES 2944 \| GSTM1 \| DISEASES 57493 \| HEG1 \| DISEASES 51329 \| ARL6IP4 \| DISEASES 4327 \| MMP19 \| DISEASES 5198 \| PFAS \| DISEASES 81037 \| CLPTM1L \| DISEASES 5062 \| PAK2 \| DISEASES 354 \| KLK3 \| DISEASES 66037 \| BOLL \| DISEASES 3556 \| IL1RAP \| DISEASES 27122 \| DKK3 \| DISEASES 1191 \| CLU \| DISEASES 6047 \| RNF4 \| DISEASES 283417 \| DPY19L2 \| DISEASES 1442 \| CSH1 \| DISEASES 4684 \| NCAM1 \| DISEASES 27086 \| FOXP1 \| DISEASES 9263 \| STK17A \| DISEASES 5652 \| PRSS8 \| DISEASES 51067 \| YARS2 \| DISEASES 3615 \| IMPDH2 \| DISEASES 3640 \| INSL3 \| DISEASES 347736 \| NME9 \| DISEASES 64840 \| PORCN \| DISEASES 4723 \| NDUFV1 \| DISEASES 64089 \| SNX16 \| DISEASES 2274 \| FHL2 \| DISEASES 57491 \| AHRR \| DISEASES 2535 \| FZD2 \| DISEASES 6605 \| SMARCE1 \| DISEASES 6794 \| STK11 \| DISEASES 5241 \| PGR \| DISEASES 113746 \| ODF3 \| DISEASES 9622 \| KLK4 \| DISEASES 1812 \| DRD1 \| DISEASES 1789 \| DNMT3B \| DISEASES 100505621 \| C11orf72 \| DISEASES 9074 \| CLDN6 \| DISEASES 83733 \| SLC25A18 \| DISEASES 9121 \| SLC16A5 \| DISEASES 842 \| CASP9 \| DISEASES 5155 \| PDGFB \| DISEASES 4496 \| MT1H \| DISEASES 7490 \| WT1 \| DISEASES 5580 \| PRKCD \| DISEASES 1485 \| CTAG1B \| DISEASES 668 \| FOXL2 \| DISEASES 266740 \| MAGEA2B \| DISEASES 153571 \| C5orf38 \| DISEASES 2626 \| GATA4 \| DISEASES 55589 \| BMP2K \| DISEASES 199720 \| GGN \| DISEASES 3320 \| HSP90AA1 \| DISEASES 1032 \| CDKN2D \| DISEASES 1551 \| CYP3A7 \| DISEASES 25818 \| KLK5 \| DISEASES 56910 \| STARD7 \| DISEASES 167 \| CRISP1 \| DISEASES 23583 \| SMUG1 \| DISEASES 8558 \| CDK10 \| DISEASES 3006 \| HIST1H1C \| DISEASES 93 \| ACVR2B \| DISEASES 81931 \| ZNF93 \| DISEASES 1544 \| CYP1A2 \| DISEASES 57515 \| SERINC1 \| DISEASES 54496 \| PRMT7 \| DISEASES 545 \| ATR \| DISEASES 10252 \| SPRY1 \| DISEASES 2100 \| ESR2 \| DISEASES 9232 \| PTTG1 \| DISEASES 81848 \| SPRY4 \| DISEASES 80705 \| TSGA10 \| DISEASES 3359 \| HTR3A \| DISEASES 7405 \| UVRAG \| DISEASES 5879 \| RAC1 \| DISEASES 122786 \| FRMD6 \| DISEASES 10146 \| G3BP1 \| DISEASES 4100 \| MAGEA1 \| DISEASES 11186 \| RASSF1 \| DISEASES 9961 \| MVP \| DISEASES 26052 \| DNM3 \| DISEASES 5573 \| PRKAR1A \| DISEASES 8323 \| FZD6 \| DISEASES 6693 \| SPN \| DISEASES 4311 \| MME \| DISEASES 4326 \| MMP17 \| DISEASES 7707 \| ZNF148 \| DISEASES 578 \| BAK1 \| DISEASES 123920 \| CMTM3 \| DISEASES 10724 \| MGEA5 \| DISEASES 10765 \| KDM5B \| DISEASES 5788 \| PTPRC \| DISEASES 3080 \| CFHR2 \| DISEASES 356 \| FASLG \| DISEASES 253738 \| EBF3 \| DISEASES 262 \| AMD1 \| DISEASES 50624 \| CUZD1 \| DISEASES 5406 \| PNLIP \| DISEASES 914 \| CD2 \| DISEASES 23036 \| ZNF292 \| DISEASES 1586 \| CYP17A1 \| DISEASES 4101 \| MAGEA2 \| DISEASES 774 \| CACNA1B \| DISEASES 11182 \| SLC2A6 \| DISEASES 10718 \| NRG3 \| DISEASES 10953 \| TOMM34 \| DISEASES 10800 \| CYSLTR1 \| DISEASES 347735 \| SERINC2 \| DISEASES 1317 \| SLC31A1 \| DISEASES 255220 \| TXNDC8 \| DISEASES 367 \| AR \| DISEASES 249 \| ALPL \| DISEASES 8894 \| EIF2S2 \| DISEASES 3293 \| HSD17B3 \| DISEASES 9371 \| KIF3B \| DISEASES 778 \| CACNA1F \| DISEASES 955 \| ENTPD6 \| DISEASES 11074 \| TRIM31 \| DISEASES 5935 \| RBM3 \| DISEASES 5987 \| TRIM27 \| DISEASES 4609 \| MYC \| DISEASES 5420 \| PODXL \| DISEASES 1543 \| CYP1A1 \| DISEASES 4093 \| SMAD9 \| DISEASES 6462 \| SHBG \| DISEASES 689 \| BTF3 \| DISEASES 3486 \| IGFBP3 \| DISEASES 29126 \| CD274 \| DISEASES 1761 \| DMRT1 \| DISEASES 2254 \| FGF9 \| DISEASES 9037 \| SEMA5A \| DISEASES 10675 \| CSPG5 \| DISEASES 3875 \| KRT18 \| DISEASES 250 \| ALPP \| DISEASES 1443 \| CSH2 \| DISEASES 2051 \| EPHB6 \| DISEASES 1106 \| CHD2 \| DISEASES 196410 \| METTL7B \| DISEASES 4501 \| MT1X \| DISEASES 174 \| AFP \| DISEASES 5744 \| PTHLH \| DISEASES 7702 \| ZNF143 \| DISEASES 2950 \| GSTP1 \| DISEASES 4839 \| NOP2 \| DISEASES 23414 \| ZFPM2 \| DISEASES 54894 \| RNF43 \| DISEASES 56888 \| KCMF1 \| DISEASES 3481 \| IGF2 \| DISEASES 2674 \| GFRA1 \| DISEASES 3833 \| KIFC1 \| DISEASES 7258 \| TSPY1 \| DISEASES 402381 \| SOHLH1 \| DISEASES 100289087 \| TSPY10 \| DISEASES 2668 \| GDNF \| DISEASES 196527 \| ANO6 \| DISEASES 3451 \| IFNA17 \| DISEASES 58155 \| PTBP2 \| DISEASES 55355 \| HJURP \| DISEASES 3831 \| KLC1 \| DISEASES 3483 \| IGFALS \| DISEASES 4193 \| MDM2 \| DISEASES 346653 \| FAM71F2 \| DISEASES 3295 \| HSD17B4 \| DISEASES 6949 \| TCOF1 \| DISEASES 10687 \| PNMA2 \| DISEASES 64641 \| EBF2 \| DISEASES 3939 \| LDHA \| DISEASES 373863 \| DND1 \| DISEASES 54937 \| SOHLH2 \| DISEASES 567 \| B2M \| DISEASES 9063 \| PIAS2 \| DISEASES 3292 \| HSD17B1 \| DISEASES 55554 \| KLK15 \| DISEASES 26085 \| KLK13 \| DISEASES 378805 \| LINC-PINT \| DISEASES 26766 \| RNU105C \| DISEASES 677825 \| SNORA44 \| DISEASES 732253 \| TDRG1 \| DISEASES 7503 \| XIST \| DISEASES
Locus	(Waiting for update.)

Disease ID	452
Disease	testicular cancer
Integrated Phenotype	(Waiting for update.)
Text Mined Phenotype	HPO \| Name \| Sentences' Count(Total Phenotypes:24) HP:0000028 \| Cryptorchidism \| 8 HP:0002664 \| Neoplasia \| 6 HP:0000789 \| Infertility \| 4 HP:0000802 \| Erectile dysfunction \| 2 HP:0100543 \| Cognitive deficits \| 2 HP:0000716 \| Depression \| 2 HP:0012125 \| Prostate cancer \| 2 HP:0100753 \| Schizophrenia \| 2 HP:0012215 \| Testicular microlithiasis \| 2 HP:0000969 \| Dropsy \| 1 HP:0002625 \| Blood clot in a deep vein \| 1 HP:0012531 \| Pain \| 1 HP:0000047 \| Hypospadias \| 1 HP:0004850 \| Recurrent deep vein thrombosis \| 1 HP:0100813 \| Testicular torsion \| 1 HP:0001250 \| Seizures \| 1 HP:0001635 \| Congestive heart failure \| 1 HP:0012876 \| Premature ejaculation \| 1 HP:0000083 \| Renal insufficiency \| 1 HP:0001919 \| Acute renal failure \| 1 HP:0000739 \| Anxiety \| 1 HP:0100728 \| Germ cell neoplasia \| 1 HP:0000027 \| Azoospermia \| 1 HP:0002181 \| Cerebral edema \| 1

Disease ID	452
Disease	testicular cancer
Manually Symptom	UMLS \| Name(Total Manually Symptoms:31) C2364072 \| depression C1963120 \| gynecomastia C1735598 \| paraneoplastic dermatomyositis C1378703 \| renal cancer C1321542 \| azoospermia C1301700 \| cardiovascular morbidity C1266157 \| intratubular germ cell neoplasia C0868910 \| oligozoospermia C0868910 \| oligospermia C0746921 \| lymph node mass C0700361 \| distress C0686619 \| lymph node metastases C0521991 \| stress symptoms C0497156 \| lymphadenopathy C0442874 \| neuropathy C0346989 \| peritoneal metastases C0345967 \| malignant mesothelioma C0338430 \| paraneoplastic limbic encephalitis C0333027 \| microlithiasis C0220650 \| brain metastases C0178829 \| genital disorder C0153687 \| skin metastasis C0086132 \| depressive symptoms C0032461 \| polycythemia C0027404 \| narcolepsy C0024232 \| lymphatic metastases C0021359 \| infertility C0020619 \| hypogonadism C0014038 \| encephalitis C0006118 \| brain tumor C0003469 \| anxiety disorder
Text Mined Symptom	UMLS \| Name \| Sentences' Count(Total Symptoms:6) C0021359 \| infertility \| 4 C1735598 \| paraneoplastic dermatomyositis \| 2 C0011570 \| depression \| 2 C0004509 \| azoospermia \| 1 C1266157 \| intratubular germ cell neoplasia \| 1 C0686619 \| lymph node metastases \| 1

Manually Genotype(Total Text Mining Genotypes:0)
(Waiting for update.)

All Snps(Total Genotypes:9)
snpId	pubmedId	geneId	geneSymbol	diseaseId	sourceId	sentence	score	Year	geneSymbol_dbSNP	CHROMOSOME	POS	REF	ALT
rs121913506	NA	3815	KIT	umls:C0153594	CLINVAR	NA	0.120542884	NA	KIT	4	54733154	G	C,T
rs137853078	NA	6794	STK11	umls:C0153594	CLINVAR	NA	0.120542884	NA	STK11	19	1220396	G	A
rs370432633	NA	8915	BCL10	umls:C0153594	CLINVAR	NA	0.122367032	NA	BCL10	1	85267841	G	A
rs4474514	19483682	4254	KITLG	umls:C0153594	GWASCAT	Common variation in KITLG and at 5q31.3 predisposes to testicular germ cell cancer.	0.124538567	2009	KITLG	12	88560182	G	A
rs4474514	19483682	4254	KITLG	umls:C0153594	GAD	[Common variation in KITLG and at 5q31.3 predisposes to testicular germ cell cancer.]	0.124538567	2009	KITLG	12	88560182	G	A
rs4590952	25220285	4254	KITLG	umls:C0153594	BeFree	Recently, a functional polymorphism in KITLG, rs4590952, was identified to be associated with testicular cancer susceptibility through increasing the p53-dependent KITLG expression and disrupting the function of p53.	0.124538567	2014	KITLG	12	88559882	A	G
rs4590952	25220285	7157	TP53	umls:C0153594	BeFree	Recently, a functional polymorphism in KITLG, rs4590952, was identified to be associated with testicular cancer susceptibility through increasing the p53-dependent KITLG expression and disrupting the function of p53.	0.00434307	2014	KITLG	12	88559882	A	G
rs7040024	21551455	1761	DMRT1	umls:C0153594	GWASCAT	A second independent locus within DMRT1 is associated with testicular germ cell tumor susceptibility.	0.12	2011	DMRT1	9	845516	A	C
rs755383	21551455	1761	DMRT1	umls:C0153594	GWASCAT	A second independent locus within DMRT1 is associated with testicular germ cell tumor susceptibility.	0.12	2011	DMRT1	9	863635	C	T

GWASdb Annotation(Total Genotypes:0)
(Waiting for update.)

GWASdb Snp Trait(Total Genotypes:41)
CHR	POS	SNPID	REF	ALT	ORI_SNPID	PMID	P_VALUE	P_VALUE_TEXT	OR/BETA	CI95_TEXT	GWAS_INITIAL_SAMPLE_SIZE	SUB_POPULATION	SUPER_POPULATION	GWAS_TRAIT	HPO_ID	HPO_TERM	DO_ID	DO_TERM	MESH_ID	MESH_TERM	EFO_ID	EFO_TERM	DOLITE_TERM	RISK_ALLELE	PUBLICATION_TYPE	AA	GENE_SYMBOL	TYPE	REFGENE
2	66167064	rs17031166	G	C	rs17031166	19483682	4.98E-06	NA	NA	NA	277 European ancestry cases; 919 European ancestry controls	European(1196)	ALL(1196)	EUR(1196)	ALL(1196)	Testicular cancer	HPOID:0010788	Testicular neoplasm	DOID:2998	testicular cancer	D013736	Testicular Neoplasms	EFOID:0005088	testicular carcinoma	Testicular tumor	NA	Research Support, N.I.H., Extramural	Research Support, Non-U.S. Gov't	C
2	66167564	rs1549383	G	A	rs1549383	19483682	1.01E-06	NA	NA	NA	277 European ancestry cases; 919 European ancestry controls	European(1196)	ALL(1196)	EUR(1196)	ALL(1196)	Testicular cancer	HPOID:0010788	Testicular neoplasm	DOID:2998	testicular cancer	D013736	Testicular Neoplasms	EFOID:0005088	testicular carcinoma	Testicular tumor	NA	Research Support, N.I.H., Extramural	Research Support, Non-U.S. Gov't	A
2	66167564	rs1549383	G	A	rs1549383	21551455	3.44E-06	NA	NA	NA	349 cases; 919 controls	NOPOP(1268)	ALL(1268)	NOPOP(1268)	ALL(1268)	Testicular cancer	HPOID:0010788	Testicular neoplasm	DOID:2998	testicular cancer	D013736	Testicular Neoplasms	EFOID:0005088	testicular carcinoma	Testicular tumor	NA	Research Support, N.I.H., Extramural	Research Support, Non-U.S. Gov't	A
2	70959327	rs3755353	G	A	rs3755353	19483682	1.77E-06	NA	NA	NA	277 European ancestry cases; 919 European ancestry controls	European(1196)	ALL(1196)	EUR(1196)	ALL(1196)	Testicular cancer	HPOID:0010788	Testicular neoplasm	DOID:2998	testicular cancer	D013736	Testicular Neoplasms	EFOID:0005088	testicular carcinoma	Testicular tumor	NA	Research Support, N.I.H., Extramural	Research Support, Non-U.S. Gov't	T
2	182377541	rs3770112	G	A	rs3770112	19483682	4.93E-08	NA	NA	NA	277 European ancestry cases; 919 European ancestry controls	European(1196)	ALL(1196)	EUR(1196)	ALL(1196)	Testicular cancer	HPOID:0010788	Testicular neoplasm	DOID:2998	testicular cancer	D013736	Testicular Neoplasms	EFOID:0005088	testicular carcinoma	Testicular tumor	NA	Research Support, N.I.H., Extramural	Research Support, Non-U.S. Gov't	C
4	128649890	rs6534637	A	C	rs6534637	19483682	1.06E-06	NA	NA	NA	277 European ancestry cases; 919 European ancestry controls	European(1196)	ALL(1196)	EUR(1196)	ALL(1196)	Testicular cancer	HPOID:0010788	Testicular neoplasm	DOID:2998	testicular cancer	D013736	Testicular Neoplasms	EFOID:0005088	testicular carcinoma	Testicular tumor	NA	Research Support, N.I.H., Extramural	Research Support, Non-U.S. Gov't	A
4	128649890	rs6534637	A	C	rs6534637	21551455	1.15E-07	NA	NA	NA	349 cases; 919 controls	NOPOP(1268)	ALL(1268)	NOPOP(1268)	ALL(1268)	Testicular cancer	HPOID:0010788	Testicular neoplasm	DOID:2998	testicular cancer	D013736	Testicular Neoplasms	EFOID:0005088	testicular carcinoma	Testicular tumor	NA	Research Support, N.I.H., Extramural	Research Support, Non-U.S. Gov't	A
5	141663364	rs12521013	A	C	rs12521013	19483682	1.99E-06	NA	NA	NA	277 European ancestry cases; 919 European ancestry controls	European(1196)	ALL(1196)	EUR(1196)	ALL(1196)	Testicular cancer	HPOID:0010788	Testicular neoplasm	DOID:2998	testicular cancer	D013736	Testicular Neoplasms	EFOID:0005088	testicular carcinoma	Testicular tumor	NA	Research Support, N.I.H., Extramural	Research Support, Non-U.S. Gov't	A
5	141663364	rs12521013	A	C	rs12521013	21551455	2.09E-06	NA	NA	NA	349 cases; 919 controls	NOPOP(1268)	ALL(1268)	NOPOP(1268)	ALL(1268)	Testicular cancer	HPOID:0010788	Testicular neoplasm	DOID:2998	testicular cancer	D013736	Testicular Neoplasms	EFOID:0005088	testicular carcinoma	Testicular tumor	NA	Research Support, N.I.H., Extramural	Research Support, Non-U.S. Gov't	A
5	141669507	rs4324715	C	T	rs4324715	19483682	2.72E-06	NA	NA	NA	277 European ancestry cases; 919 European ancestry controls	European(1196)	ALL(1196)	EUR(1196)	ALL(1196)	Testicular cancer	HPOID:0010788	Testicular neoplasm	DOID:2998	testicular cancer	D013736	Testicular Neoplasms	EFOID:0005088	testicular carcinoma	Testicular tumor	NA	Research Support, N.I.H., Extramural	Research Support, Non-U.S. Gov't	C
5	141687639	rs6897876	T	C	rs6897876	19483682	1.77E-06	NA	NA	NA	277 European ancestry cases; 919 European ancestry controls	European(1196)	ALL(1196)	EUR(1196)	ALL(1196)	Testicular cancer	HPOID:0010788	Testicular neoplasm	DOID:2998	testicular cancer	D013736	Testicular Neoplasms	EFOID:0005088	testicular carcinoma	Testicular tumor	NA	Research Support, N.I.H., Extramural	Research Support, Non-U.S. Gov't	T
5	141687639	rs6897876	T	C	rs6897876	21551455	1.87E-06	NA	NA	NA	349 cases; 919 controls	NOPOP(1268)	ALL(1268)	NOPOP(1268)	ALL(1268)	Testicular cancer	HPOID:0010788	Testicular neoplasm	DOID:2998	testicular cancer	D013736	Testicular Neoplasms	EFOID:0005088	testicular carcinoma	Testicular tumor	NA	Research Support, N.I.H., Extramural	Research Support, Non-U.S. Gov't	T
6	65034184	rs7774545	G	A,T	rs7774545	19483682	1.83E-06	NA	NA	NA	277 European ancestry cases; 919 European ancestry controls	European(1196)	ALL(1196)	EUR(1196)	ALL(1196)	Testicular cancer	HPOID:0010788	Testicular neoplasm	DOID:2998	testicular cancer	D013736	Testicular Neoplasms	EFOID:0005088	testicular carcinoma	Testicular tumor	NA	Research Support, N.I.H., Extramural	Research Support, Non-U.S. Gov't	A
7	52898154	rs2965606	T	A	rs2965606	19483682	4.78E-06	NA	NA	NA	277 European ancestry cases; 919 European ancestry controls	European(1196)	ALL(1196)	EUR(1196)	ALL(1196)	Testicular cancer	HPOID:0010788	Testicular neoplasm	DOID:2998	testicular cancer	D013736	Testicular Neoplasms	EFOID:0005088	testicular carcinoma	Testicular tumor	NA	Research Support, N.I.H., Extramural	Research Support, Non-U.S. Gov't	A
7	90385330	rs10281060	G	C	rs10281060	21551455	2.19E-06	NA	NA	NA	349 cases; 919 controls	NOPOP(1268)	ALL(1268)	NOPOP(1268)	ALL(1268)	Testicular cancer	HPOID:0010788	Testicular neoplasm	DOID:2998	testicular cancer	D013736	Testicular Neoplasms	EFOID:0005088	testicular carcinoma	Testicular tumor	NA	Research Support, N.I.H., Extramural	Research Support, Non-U.S. Gov't	G
7	90413101	rs6951213	G	A	rs6951213	21551455	2.75E-06	NA	NA	NA	349 cases; 919 controls	NOPOP(1268)	ALL(1268)	NOPOP(1268)	ALL(1268)	Testicular cancer	HPOID:0010788	Testicular neoplasm	DOID:2998	testicular cancer	D013736	Testicular Neoplasms	EFOID:0005088	testicular carcinoma	Testicular tumor	NA	Research Support, N.I.H., Extramural	Research Support, Non-U.S. Gov't	G
7	91669808	rs6961928	G	A	rs6961928	19483682	1.83E-06	NA	NA	NA	277 European ancestry cases; 919 European ancestry controls	European(1196)	ALL(1196)	EUR(1196)	ALL(1196)	Testicular cancer	HPOID:0010788	Testicular neoplasm	DOID:2998	testicular cancer	D013736	Testicular Neoplasms	EFOID:0005088	testicular carcinoma	Testicular tumor	NA	Research Support, N.I.H., Extramural	Research Support, Non-U.S. Gov't	A
8	90331084	rs4568650	A	C	rs4568650	21551455	4.52E-06	NA	NA	NA	349 cases; 919 controls	NOPOP(1268)	ALL(1268)	NOPOP(1268)	ALL(1268)	Testicular cancer	HPOID:0010788	Testicular neoplasm	DOID:2998	testicular cancer	D013736	Testicular Neoplasms	EFOID:0005088	testicular carcinoma	Testicular tumor	NA	Research Support, N.I.H., Extramural	Research Support, Non-U.S. Gov't	A
9	845516	rs7040024	A	C	rs7040024	21551455	1.00E-11	NA	1.7	[1.46-1.99]	349 cases; 919 controls	NOPOP(1268)	ALL(1268)	NOPOP(1268)	ALL(1268)	Testicular cancer	HPOID:0010788	Testicular neoplasm	DOID:2998	testicular cancer	D013736	Testicular Neoplasms	EFOID:0005088	testicular carcinoma	Testicular tumor	rs7040024-A	Research Support, N.I.H., Extramural	Research Support, Non-U.S. Gov't	A
9	863635	rs755383	C	T	rs755383	21551455	9.00E-10	NA	1.5	[1.32-1.71]	349 cases; 919 controls	NOPOP(1268)	ALL(1268)	NOPOP(1268)	ALL(1268)	Testicular cancer	HPOID:0010788	Testicular neoplasm	DOID:2998	testicular cancer	D013736	Testicular Neoplasms	EFOID:0005088	testicular carcinoma	Testicular tumor	rs755383-T	Research Support, N.I.H., Extramural	Research Support, Non-U.S. Gov't	C
12	88847001	rs7486184	A	G	rs7486184	19483682	4.56E-07	NA	NA	NA	277 European ancestry cases; 919 European ancestry controls	European(1196)	ALL(1196)	EUR(1196)	ALL(1196)	Testicular cancer	HPOID:0010788	Testicular neoplasm	DOID:2998	testicular cancer	D013736	Testicular Neoplasms	EFOID:0005088	testicular carcinoma	Testicular tumor	NA	Research Support, N.I.H., Extramural	Research Support, Non-U.S. Gov't	G
12	88847001	rs7486184	A	G	rs7486184	21551455	3.95E-07	NA	NA	NA	349 cases; 919 controls	NOPOP(1268)	ALL(1268)	NOPOP(1268)	ALL(1268)	Testicular cancer	HPOID:0010788	Testicular neoplasm	DOID:2998	testicular cancer	D013736	Testicular Neoplasms	EFOID:0005088	testicular carcinoma	Testicular tumor	NA	Research Support, N.I.H., Extramural	Research Support, Non-U.S. Gov't	G
12	88890671	rs995030	A	G	rs995030	19483682	7.47E-09	NA	NA	NA	277 European ancestry cases; 919 European ancestry controls	European(1196)	ALL(1196)	EUR(1196)	ALL(1196)	Testicular cancer	HPOID:0010788	Testicular neoplasm	DOID:2998	testicular cancer	D013736	Testicular Neoplasms	EFOID:0005088	testicular carcinoma	Testicular tumor	NA	Research Support, N.I.H., Extramural	Research Support, Non-U.S. Gov't	A
12	88890671	rs995030	A	G	rs995030	21551455	5.78E-10	NA	NA	NA	349 cases; 919 controls	NOPOP(1268)	ALL(1268)	NOPOP(1268)	ALL(1268)	Testicular cancer	HPOID:0010788	Testicular neoplasm	DOID:2998	testicular cancer	D013736	Testicular Neoplasms	EFOID:0005088	testicular carcinoma	Testicular tumor	NA	Research Support, N.I.H., Extramural	Research Support, Non-U.S. Gov't	A
12	88951485	rs1472899	C	T	rs1472899	19483682	3.09E-09	NA	NA	NA	277 European ancestry cases; 919 European ancestry controls	European(1196)	ALL(1196)	EUR(1196)	ALL(1196)	Testicular cancer	HPOID:0010788	Testicular neoplasm	DOID:2998	testicular cancer	D013736	Testicular Neoplasms	EFOID:0005088	testicular carcinoma	Testicular tumor	NA	Research Support, N.I.H., Extramural	Research Support, Non-U.S. Gov't	G
12	88951485	rs1472899	C	T	rs1472899	21551455	4.08E-10	NA	NA	NA	349 cases; 919 controls	NOPOP(1268)	ALL(1268)	NOPOP(1268)	ALL(1268)	Testicular cancer	HPOID:0010788	Testicular neoplasm	DOID:2998	testicular cancer	D013736	Testicular Neoplasms	EFOID:0005088	testicular carcinoma	Testicular tumor	NA	Research Support, N.I.H., Extramural	Research Support, Non-U.S. Gov't	G
12	88953326	rs3782179	C	T	rs3782179	19483682	1.35E-09	NA	NA	NA	277 European ancestry cases; 919 European ancestry controls	European(1196)	ALL(1196)	EUR(1196)	ALL(1196)	Testicular cancer	HPOID:0010788	Testicular neoplasm	DOID:2998	testicular cancer	D013736	Testicular Neoplasms	EFOID:0005088	testicular carcinoma	Testicular tumor	NA	Research Support, N.I.H., Extramural	Research Support, Non-U.S. Gov't	T
12	88953326	rs3782179	C	T	rs3782179	21551455	1.82E-10	NA	NA	NA	349 cases; 919 controls	NOPOP(1268)	ALL(1268)	NOPOP(1268)	ALL(1268)	Testicular cancer	HPOID:0010788	Testicular neoplasm	DOID:2998	testicular cancer	D013736	Testicular Neoplasms	EFOID:0005088	testicular carcinoma	Testicular tumor	NA	Research Support, N.I.H., Extramural	Research Support, Non-U.S. Gov't	T
12	88953561	rs3782181	C	A	rs3782181	19483682	8.38E-10	NA	NA	NA	277 European ancestry cases; 919 European ancestry controls	European(1196)	ALL(1196)	EUR(1196)	ALL(1196)	Testicular cancer	HPOID:0010788	Testicular neoplasm	DOID:2998	testicular cancer	D013736	Testicular Neoplasms	EFOID:0005088	testicular carcinoma	Testicular tumor	NA	Research Support, N.I.H., Extramural	Research Support, Non-U.S. Gov't	C
12	88953561	rs3782181	C	A	rs3782181	21551455	1.11E-10	NA	NA	NA	349 cases; 919 controls	NOPOP(1268)	ALL(1268)	NOPOP(1268)	ALL(1268)	Testicular cancer	HPOID:0010788	Testicular neoplasm	DOID:2998	testicular cancer	D013736	Testicular Neoplasms	EFOID:0005088	testicular carcinoma	Testicular tumor	NA	Research Support, N.I.H., Extramural	Research Support, Non-U.S. Gov't	C
12	88953959	rs4474514	G	A	rs4474514	19483682	6.00E-15	NA	3.07	[2.29-4.13]	277 European ancestry cases; 919 European ancestry controls	European(1196)	ALL(1196)	EUR(1196)	ALL(1196)	Testicular cancer	HPOID:0010788	Testicular neoplasm	DOID:2998	testicular cancer	D013736	Testicular Neoplasms	EFOID:0005088	testicular carcinoma	Testicular tumor	rs4474514-A	Research Support, N.I.H., Extramural	Research Support, Non-U.S. Gov't	G
12	88953959	rs4474514	G	A	rs4474514	21551455	7.08E-11	NA	NA	NA	349 cases; 919 controls	NOPOP(1268)	ALL(1268)	NOPOP(1268)	ALL(1268)	Testicular cancer	HPOID:0010788	Testicular neoplasm	DOID:2998	testicular cancer	D013736	Testicular Neoplasms	EFOID:0005088	testicular carcinoma	Testicular tumor	NA	Research Support, N.I.H., Extramural	Research Support, Non-U.S. Gov't	G
12	88956400	rs11104952	T	G	rs11104952	19483682	1.90E-09	NA	NA	NA	277 European ancestry cases; 919 European ancestry controls	European(1196)	ALL(1196)	EUR(1196)	ALL(1196)	Testicular cancer	HPOID:0010788	Testicular neoplasm	DOID:2998	testicular cancer	D013736	Testicular Neoplasms	EFOID:0005088	testicular carcinoma	Testicular tumor	NA	Research Support, N.I.H., Extramural	Research Support, Non-U.S. Gov't	G
12	88956400	rs11104952	T	G	rs11104952	21551455	3.58E-10	NA	NA	NA	349 cases; 919 controls	NOPOP(1268)	ALL(1268)	NOPOP(1268)	ALL(1268)	Testicular cancer	HPOID:0010788	Testicular neoplasm	DOID:2998	testicular cancer	D013736	Testicular Neoplasms	EFOID:0005088	testicular carcinoma	Testicular tumor	NA	Research Support, N.I.H., Extramural	Research Support, Non-U.S. Gov't	G
12	88960727	rs1352947	C	T	rs1352947	19483682	4.24E-09	NA	NA	NA	277 European ancestry cases; 919 European ancestry controls	European(1196)	ALL(1196)	EUR(1196)	ALL(1196)	Testicular cancer	HPOID:0010788	Testicular neoplasm	DOID:2998	testicular cancer	D013736	Testicular Neoplasms	EFOID:0005088	testicular carcinoma	Testicular tumor	NA	Research Support, N.I.H., Extramural	Research Support, Non-U.S. Gov't	A
12	88960727	rs1352947	C	T	rs1352947	21551455	1.01E-09	NA	NA	NA	349 cases; 919 controls	NOPOP(1268)	ALL(1268)	NOPOP(1268)	ALL(1268)	Testicular cancer	HPOID:0010788	Testicular neoplasm	DOID:2998	testicular cancer	D013736	Testicular Neoplasms	EFOID:0005088	testicular carcinoma	Testicular tumor	NA	Research Support, N.I.H., Extramural	Research Support, Non-U.S. Gov't	A
12	89012852	rs2639101	A	C	rs2639101	21551455	1.37E-06	NA	NA	NA	349 cases; 919 controls	NOPOP(1268)	ALL(1268)	NOPOP(1268)	ALL(1268)	Testicular cancer	HPOID:0010788	Testicular neoplasm	DOID:2998	testicular cancer	D013736	Testicular Neoplasms	EFOID:0005088	testicular carcinoma	Testicular tumor	NA	Research Support, N.I.H., Extramural	Research Support, Non-U.S. Gov't	G
13	31276728	rs6490478	G	T	rs6490478	21551455	2.56E-07	NA	NA	NA	349 cases; 919 controls	NOPOP(1268)	ALL(1268)	NOPOP(1268)	ALL(1268)	Testicular cancer	HPOID:0010788	Testicular neoplasm	DOID:2998	testicular cancer	D013736	Testicular Neoplasms	EFOID:0005088	testicular carcinoma	Testicular tumor	NA	Research Support, N.I.H., Extramural	Research Support, Non-U.S. Gov't	T
18	25237011	rs7236484	T	A	rs7236484	19483682	1.61E-06	NA	NA	NA	277 European ancestry cases; 919 European ancestry controls	European(1196)	ALL(1196)	EUR(1196)	ALL(1196)	Testicular cancer	HPOID:0010788	Testicular neoplasm	DOID:2998	testicular cancer	D013736	Testicular Neoplasms	EFOID:0005088	testicular carcinoma	Testicular tumor	NA	Research Support, N.I.H., Extramural	Research Support, Non-U.S. Gov't	T
X	91162118	rs2524594	G	A	rs2524594	19483682	8.91E-07	NA	NA	NA	277 European ancestry cases; 919 European ancestry controls	European(1196)	ALL(1196)	EUR(1196)	ALL(1196)	Testicular cancer	HPOID:0010788	Testicular neoplasm	DOID:2998	testicular cancer	D013736	Testicular Neoplasms	EFOID:0005088	testicular carcinoma	Testicular tumor	NA	Research Support, N.I.H., Extramural	Research Support, Non-U.S. Gov't	A
X	124505129	rs1964186	C	T	rs1964186	21551455	3.25E-06	NA	NA	NA	349 cases; 919 controls	NOPOP(1268)	ALL(1268)	NOPOP(1268)	ALL(1268)	Testicular cancer	HPOID:0010788	Testicular neoplasm	DOID:2998	testicular cancer	D013736	Testicular Neoplasms	EFOID:0005088	testicular carcinoma	Testicular tumor	NA	Research Support, N.I.H., Extramural	Research Support, Non-U.S. Gov't	T

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Mapped by homologous gene(Total Items:0)
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FDA approved drug and dosage information(Total Drugs:0)
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