PedAM

Pediatric Disease Annotations & Medicines


	temporal arteritis

Disease ID	232
Disease	temporal arteritis
Definition	subacute, granulomatous arteritis involving the external carotid arteries, especially the temporal artery; occurs in elderly persons and may be manifested by constitutional symptoms, particularly severe headache, and sometimes sudden unilateral blindness; shares many of the symptoms of polymyalgia rheumatica.
Synonym	arteritides, temporal arteritis temporal arteritis, temporal ta - temporal arteritis temporal arteritides temporal arteritis (disorder) temporal giant cell arteritis
OMIM	OMIM:187360
DOID	DOID:13375
UMLS	C1956391
SNOMED-CT	SNOMEDCT_US_2016_09_01:400130008
Comorbidity	UMLS \| Disease \| Sentences' Count(Total Sentences:11) C0032533 \| polymyalgia rheumatica \| 2 C0028841 \| ocular hypotony \| 1 C0149931 \| migraine \| 1 C0007117 \| basal cell carcinoma \| 1 C0040997 \| trigeminal neuralgia \| 1 C0040053 \| thrombosis \| 1 C0003864 \| arthritis \| 1 C0003873 \| rheumatoid arthritis \| 1 C0040028 \| essential thrombocythaemia \| 1 C0026764 \| multiple myeloma \| 1 C0154723 \| migraine with aura \| 1
Curated Gene	Entrez_id \| Symbol \| Resource(Total Genes:1) PTPN22 \| 26191 \| ORPHANET
Inferring Gene	(Waiting for update.)
Text Mined Gene	Entrez_id \| Symbol \| Score \| Resource(Total Genes:116) 8974 \| P4HA2 \| DISEASES 350 \| APOH \| DISEASES 7414 \| VCL \| DISEASES 26517 \| TIMM13 \| DISEASES 4282 \| MIF \| DISEASES 1511 \| CTSG \| DISEASES 7076 \| TIMP1 \| DISEASES 4313 \| MMP2 \| DISEASES 26258 \| BLOC1S6 \| DISEASES 8797 \| TNFRSF10A \| DISEASES 973 \| CD79A \| DISEASES 6822 \| SULT2A1 \| DISEASES 4353 \| MPO \| DISEASES 6347 \| CCL2 \| DISEASES 3558 \| IL2 \| DISEASES 3458 \| IFNG \| DISEASES 3820 \| KLRB1 \| DISEASES 2908 \| NR3C1 \| DISEASES 5657 \| PRTN3 \| DISEASES 6402 \| SELL \| DISEASES 7128 \| TNFAIP3 \| DISEASES 27230 \| SERP1 \| DISEASES 1236 \| CCR7 \| DISEASES 968 \| CD68 \| DISEASES 11026 \| LILRA3 \| DISEASES 2006 \| ELN \| DISEASES 3866 \| KRT15 \| DISEASES 1401 \| CRP \| DISEASES 55303 \| GIMAP4 \| DISEASES 3569 \| IL6 \| DISEASES 640 \| BLK \| DISEASES 3557 \| IL1RN \| DISEASES 6366 \| CCL21 \| DISEASES 2615 \| LRRC32 \| DISEASES 7450 \| VWF \| DISEASES 3595 \| IL12RB2 \| DISEASES 51816 \| CECR1 \| DISEASES 3553 \| IL1B \| DISEASES 1991 \| ELANE \| DISEASES 6403 \| SELP \| DISEASES 5443 \| POMC \| DISEASES 3383 \| ICAM1 \| DISEASES 29999 \| FSCN3 \| DISEASES 10261 \| IGSF6 \| DISEASES 2212 \| FCGR2A \| DISEASES 2495 \| FTH1 \| DISEASES 3578 \| IL9 \| DISEASES 3606 \| IL18 \| DISEASES 83648 \| FAM167A \| DISEASES 231 \| AKR1B1 \| DISEASES 10563 \| CXCL13 \| DISEASES 1234 \| CCR5 \| DISEASES 6352 \| CCL5 \| DISEASES 2215 \| FCGR3B \| DISEASES 1493 \| CTLA4 \| DISEASES 54205 \| CYCS \| DISEASES 6363 \| CCL19 \| DISEASES 8302 \| KLRC4 \| DISEASES 8636 \| SSNA1 \| DISEASES 147912 \| SIX5 \| DISEASES 55024 \| BANK1 \| DISEASES 149233 \| IL23R \| DISEASES 9235 \| IL32 \| DISEASES 6938 \| TCF12 \| DISEASES 6401 \| SELE \| DISEASES 9094 \| UNC119 \| DISEASES 50615 \| IL21R \| DISEASES 23583 \| SMUG1 \| DISEASES 445329 \| SULT1A4 \| DISEASES 3117 \| HLA-DQA1 \| DISEASES 7100 \| TLR5 \| DISEASES 6818 \| SULT1A3 \| DISEASES 3605 \| IL17A \| DISEASES 57556 \| SEMA6A \| DISEASES 3921 \| RPSA \| DISEASES 3240 \| HP \| DISEASES 6288 \| SAA1 \| DISEASES 6775 \| STAT4 \| DISEASES 26191 \| PTPN22 \| DISEASES 3123 \| HLA-DRB1 \| DISEASES 54106 \| TLR9 \| DISEASES 4283 \| CXCL9 \| DISEASES 7044 \| LEFTY2 \| DISEASES 3459 \| IFNGR1 \| DISEASES 6283 \| S100A12 \| DISEASES 965 \| CD58 \| DISEASES 3654 \| IRAK1 \| DISEASES 959 \| CD40LG \| DISEASES 4318 \| MMP9 \| DISEASES 7417 \| VDAC2 \| DISEASES 1025 \| CDK9 \| DISEASES 7099 \| TLR4 \| DISEASES 10673 \| TNFSF13B \| DISEASES 100507436 \| MICA \| DISEASES 7133 \| TNFRSF1B \| DISEASES 3604 \| TNFRSF9 \| DISEASES 8718 \| TNFRSF25 \| DISEASES 5422 \| POLA1 \| DISEASES 9308 \| CD83 \| DISEASES 1906 \| EDN1 \| DISEASES 51284 \| TLR7 \| DISEASES 90865 \| IL33 \| DISEASES 6624 \| FSCN1 \| DISEASES 6996 \| TDG \| DISEASES 12 \| SERPINA3 \| DISEASES 56138 \| PCDHA11 \| DISEASES 7124 \| TNF \| DISEASES 3106 \| HLA-B \| DISEASES 3586 \| IL10 \| DISEASES 26298 \| EHF \| DISEASES 3684 \| ITGAM \| DISEASES 27229 \| TUBGCP4 \| DISEASES 22861 \| NLRP1 \| DISEASES 6625 \| SNRNP70 \| DISEASES 79104 \| MEG8 \| DISEASES 26774 \| SNORD80 \| DISEASES
Locus	(Waiting for update.)

Disease ID	232
Disease	temporal arteritis
Integrated Phenotype	HPO \| Name(Total Integrated Phenotypes:3) HP:0000618 \| Blindness HP:0003565 \| Elevated sedimentation rate HP:0008030 \| Retinal arteritis
Text Mined Phenotype	HPO \| Name \| Sentences' Count(Total Phenotypes:13) HP:0002315 \| Headaches \| 4 HP:0001370 \| Rheumatoid arthritis \| 1 HP:0003565 \| Elevated sedimentation rate \| 1 HP:0002077 \| Migraine with aura \| 1 HP:0006775 \| Multiple myeloma \| 1 HP:0001880 \| Eosinophilia \| 1 HP:0002671 \| Basalioma \| 1 HP:0002076 \| Migraine headaches \| 1 HP:0100661 \| Trigeminal neuralgia \| 1 HP:0001369 \| Arthritis \| 1 HP:0030164 \| Jaw claudication \| 1 HP:0004936 \| Blood clot in vein \| 1 HP:0012474 \| Obstructed carotid artery \| 1

Disease ID	232
Disease	temporal arteritis
Manually Symptom	UMLS \| Name(Total Manually Symptoms:57) C2700511 \| erythroleukemia C2240374 \| eosinophilia C2168170 \| leg claudication C2096315 \| headache C2073625 \| pleural effusion C2046121 \| aortic dissection C2029884 \| hearing loss C1963736 \| tongue necrosis C1963154 \| renal failure C1962966 \| retinopathy C1879328 \| bilateral blindness C1562901 \| peripheral ulcerative keratitis C1402315 \| vascular lesions C1336970 \| visual manifestations C1304164 \| generalized granuloma annulare C1290884 \| inflammatory disease C1253936 \| synovial effusion C1180561 \| internal elastic lamina C1148477 \| sudden deafness C1000483 \| anemia C0836924 \| thrombocytosis C0752303 \| urological manifestations C0522224 \| palsy C0521516 \| polymyalgia C0517555 \| venous thrombosis C0456909 \| loss of vision C0456909 \| blindness C0344232 \| blurred vision C0339731 \| charles bonnet syndrome C0271240 \| unilateral blindness C0239819 \| hand edema C0234362 \| synkinesis C0231243 \| early complication C0221390 \| marantic endocarditis C0162323 \| polyarthritis C0155339 \| brown syndrome C0039483 \| giant cell arteritis C0037284 \| skin lesions C0037090 \| respiratory symptoms C0036454 \| visual field loss C0036454 \| visual field defects C0036220 \| kaposi's sarcoma C0031117 \| peripheral neuropathy C0030167 \| pachymeningitis C0029118 \| opportunistic infections C0027726 \| nephrotic syndrome C0022658 \| renal disease C0022116 \| ischemia C0021845 \| intestinal perforation C0021308 \| infarction C0020676 \| hypothyroidism C0020635 \| hypopituitarism C0020550 \| hyperthyroidism C0019937 \| horner's syndrome C0017086 \| gangrene C0007688 \| central retinal artery occlusion C0007286 \| carpal tunnel syndrome
Text Mined Symptom	UMLS \| Name \| Sentences' Count(Total Symptoms:7) C0018681 \| headache \| 3 C0521516 \| polymyalgia \| 2 C0037284 \| skin lesions \| 1 C0042487 \| venous thrombosis \| 1 C0014457 \| eosinophilia \| 1 C1180561 \| internal elastic lamina \| 1 C1963736 \| tongue necrosis \| 1

Manually Genotype(Total Text Mining Genotypes:0)
(Waiting for update.)

All Snps(Total Genotypes:2)
snpId	pubmedId	geneId	geneSymbol	diseaseId	sourceId	sentence	score	Year	geneSymbol_dbSNP	CHROMOSOME	POS	REF	ALT
rs1883832	20682661	958	CD40	umls:C1956391	GAD	[Our results suggest a potential implication of the CD40 rs1883832 C/T polymorphism in susceptibility to visual ischemic manifestations in individuals with biopsy-proven GCA.]	0.002367032	2010	CD40	20	46118343	T	C
rs2104286	20810507	3559	IL2RA	umls:C1956391	GAD	[IL2RA rs2104286 polymorphism does not appear to be a genetic risk factor for susceptibility to biopsy-proven GCA. Also, this polymorphism does not seem to be implicated in the clinical expression of this vasculitis.]	0.002367032	2010	IL2RA	10	6057082	T	C

GWASdb Annotation(Total Genotypes:0)
(Waiting for update.)

GWASdb Snp Trait(Total Genotypes:0)
(Waiting for update.)

Mapped by lexical matching(Total Items:1)
HP ID	HP Name	MP ID	MP Name	Annotation
HP:0003565	Elevated erythrocyte sedimentation rate	MP:0002875	decreased erythrocyte cell number;HP:0000405	Conductive hearing impairment

Mapped by homologous gene(Total Items:1)
HP ID	HP Name	MP ID	MP Name	Annotation
HP:0003565	Elevated erythrocyte sedimentation rate	MP:0002334	abnormal airway responsiveness;HP:0003401	Paresthesia

Chemical(Total Drugs:0)
(Waiting for update.)

FDA approved drug and dosage information(Total Drugs:0)
(Waiting for update.)

FDA labeling changes(Total Drugs:0)
(Waiting for update.)

Web
Analytics