PedAM

Pediatric Disease Annotations & Medicines


	systemic scleroderma

Disease ID	59
Disease	systemic scleroderma
Definition	A chronic multi-system disorder of CONNECTIVE TISSUE. It is characterized by SCLEROSIS in the SKIN, the LUNGS, the HEART, the GASTROINTESTINAL TRACT, the KIDNEYS, and the MUSCULOSKELETAL SYSTEM. Other important features include diseased small BLOOD VESSELS and AUTOANTIBODIES. The disorder is named for its most prominent feature (hard skin), and classified into subsets by the extent of skin thickening: LIMITED SCLERODERMA and DIFFUSE SCLERODERMA.
Synonym	diffuse scleroderma progressive systemic sclerosis pss pss (progressive systemic sclerosis) pss - progressive systemic sclerosis scleroderma syndrome scleroderma syndrome (disorder) scleroderma, diffuse scleroderma, systemic scleroderma, systemic [disease/finding] sclerosis, systemic ss - systemic sclerosis ssc, diffuse sclerosis systemic sclerosis systemic sclerosis (disorder)
Orphanet	ORPHANET:90291
OMIM	OMIM:601224
DOID	DOID:418 DOID:1580
ICD10	ICD10CM:M34.0
UMLS	C0036421
MeSH	D012595 D045743
SNOMED-CT	SNOMEDCT_US_2016_09_01:89155008
Comorbidity	UMLS \| Disease \| Sentences' Count(Total Sentences:11) C0020542 \| pulmonary hypertension \| 1 C0270612 \| leukoencephalopathy \| 1 C0036421 \| systemic sclerosis \| 1 C0042870 \| vitamin d defic \| 1 C0022658 \| renal disease \| 1 C0020538 \| hypertension \| 1 C0027121 \| myositis \| 1 C0037274 \| skin disease \| 1 C0042870 \| vitamin d deficiency \| 1 C0022661 \| chronic renal disease \| 1 C0155765 \| microangiopathy \| 1
Curated Gene	Entrez_id \| Symbol \| Resource(Total Genes:28) PXK \| 54899 \| GWASCAT HLA-DPA1 \| 3113 \| GWASCAT C6orf10 \| 10665 \| GWASCAT STAT4 \| 6775 \| CTD_human;GWASCAT;GHR HLA-DPB1 \| 3115 \| GWASCAT BLK \| 640 \| GHR TNIP1 \| 10318 \| CTD_human;GWASCAT PTPN22 \| 26191 \| GHR HLA-DQB1 \| 3119 \| CTD_human BANK1 \| 55024 \| GHR IRF5 \| 3663 \| CTD_human;GHR KIAA0319L \| 79932 \| GWASCAT CD247 \| 919 \| CTD_human;GWASCAT ATG5 \| 9474 \| GWASCAT TNFSF4 \| 7292 \| GHR TNPO3 \| 23534 \| GWASCAT ITGAM \| 3684 \| GWASCAT SOX5 \| 6660 \| GWASCAT SAMD9L \| 219285 \| GWASCAT JAZF1 \| 221895 \| GWASCAT RHOB \| 388 \| CTD_human PSORS1C2 \| 170680 \| GWASCAT PSORS1C1 \| 170679 \| CTD_human;GWASCAT HLA-DRA \| 3122 \| GWASCAT NOTCH4 \| 4855 \| GWASCAT GRB10 \| 2887 \| GWASCAT TPI1P2 \| 286016 \| GWASCAT ANKS1A \| 23294 \| GWASCAT
Inferring Gene	Entrez_id \| Symbol \| Resource(Total Genes:72) 3588 \| IL10RB \| infer 55024 \| BANK1 \| infer 6347 \| CCL2 \| infer 919 \| CD247 \| infer 1306 \| COL15A1 \| infer 1490 \| CTGF \| infer 2099 \| ESR1 \| infer 2100 \| ESR2 \| infer 355 \| FAS \| infer 2200 \| FBN1 \| infer 2887 \| GRB10 \| infer 3113 \| HLA-DPA1 \| infer 3115 \| HLA-DPB1 \| infer 3117 \| HLA-DQA1 \| infer 3119 \| HLA-DQB1 \| infer 3122 \| HLA-DRA \| infer 3123 \| HLA-DRB1 \| infer 3356 \| HTR2A \| infer 3458 \| IFNG \| infer 3586 \| IL10 \| infer 3554 \| IL1R1 \| infer 3558 \| IL2 \| infer 149233 \| IL23R \| infer 3569 \| IL6 \| infer 3663 \| IRF5 \| infer 3394 \| IRF8 \| infer 4855 \| NOTCH4 \| infer 26191 \| PTPN22 \| infer 5788 \| PTPRC \| infer 6660 \| SOX5 \| infer 6775 \| STAT4 \| infer 23534 \| TNPO3 \| infer 84872 \| ZC3H10 \| infer 199 \| AIF1 \| infer 326 \| AIRE \| infer 6352 \| CCL5 \| infer 930 \| CD19 \| infer 933 \| CD22 \| infer 942 \| CD86 \| infer 1493 \| CTLA4 \| infer 1535 \| CYBA \| infer 1906 \| EDN1 \| infer 1909 \| EDNRA \| infer 1910 \| EDNRB \| infer 3126 \| HLA-DRB4 \| infer 3127 \| HLA-DRB5 \| infer 3596 \| IL13 \| infer 3598 \| IL13RA2 \| infer 3552 \| IL1A \| infer 3553 \| IL1B \| infer 3557 \| IL1RN \| infer 4049 \| LTA \| infer 4846 \| NOS3 \| infer 6890 \| TAP1 \| infer 6891 \| TAP2 \| infer 7012 \| TERC \| infer 7076 \| TIMP1 \| infer 7124 \| TNF \| infer 7133 \| TNFRSF1B \| infer 7422 \| VEGFA \| infer 1636 \| ACE \| infer 1278 \| COL1A2 \| infer 1557 \| CYP2C19 \| infer 1571 \| CYP2E1 \| infer 2335 \| FN1 \| infer 3116 \| HLA-DPB2 \| infer 4312 \| MMP1 \| infer 5155 \| PDGFB \| infer 30009 \| TBX21 \| infer 7040 \| TGFB1 \| infer 7292 \| TNFSF4 \| infer 10318 \| TNIP1 \| infer
Text Mined Gene	Entrez_id \| Symbol \| Score \| Resource(Total Genes:520) 6362 \| CCL18 \| DISEASES 6376 \| CX3CL1 \| DISEASES 64132 \| XYLT2 \| DISEASES 1634 \| DCN \| DISEASES 10911 \| UTS2 \| DISEASES 5954 \| RCN1 \| DISEASES 51564 \| HDAC7 \| DISEASES 933 \| CD22 \| DISEASES 30009 \| TBX21 \| DISEASES 5019 \| OXCT1 \| DISEASES 5019 \| OXCT1 \| DISEASES 350 \| APOH \| DISEASES 9552 \| SPAG7 \| DISEASES 7414 \| VCL \| DISEASES 4282 \| MIF \| DISEASES 4282 \| MIF \| DISEASES 5008 \| OSM \| DISEASES 5008 \| OSM \| DISEASES 79019 \| CENPM \| DISEASES 1511 \| CTSG \| DISEASES 1511 \| CTSG \| DISEASES 4605 \| MYBL2 \| DISEASES 51311 \| TLR8 \| DISEASES 7076 \| TIMP1 \| DISEASES 479 \| ATP12A \| DISEASES 4313 \| MMP2 \| DISEASES 80152 \| CENPT \| DISEASES 7038 \| TG \| DISEASES 5327 \| PLAT \| DISEASES 8797 \| TNFRSF10A \| DISEASES 2091 \| FBL \| DISEASES 2091 \| FBL \| DISEASES 7040 \| TGFB1 \| DISEASES 973 \| CD79A \| DISEASES 1311 \| COMP \| DISEASES 3082 \| HGF \| DISEASES 5054 \| SERPINE1 \| DISEASES 5054 \| SERPINE1 \| DISEASES 6119 \| RPA3 \| DISEASES 6348 \| CCL3 \| DISEASES 4353 \| MPO \| DISEASES 1440 \| CSF3 \| DISEASES 6347 \| CCL2 \| DISEASES 6357 \| CCL13 \| DISEASES 1277 \| COL1A1 \| DISEASES 1277 \| COL1A1 \| DISEASES 4790 \| NFKB1 \| DISEASES 3558 \| IL2 \| DISEASES 969 \| CD69 \| DISEASES 6404 \| SELPLG \| DISEASES 55801 \| IL26 \| DISEASES 3458 \| IFNG \| DISEASES 3458 \| IFNG \| DISEASES 3820 \| KLRB1 \| DISEASES 4015 \| LOX \| DISEASES 6678 \| SPARC \| DISEASES 7265 \| TTC1 \| DISEASES 3565 \| IL4 \| DISEASES 9136 \| RRP9 \| DISEASES 9136 \| RRP9 \| DISEASES 3488 \| IGFBP5 \| DISEASES 5657 \| PRTN3 \| DISEASES 5657 \| PRTN3 \| DISEASES 6402 \| SELL \| DISEASES 7128 \| TNFAIP3 \| DISEASES 7043 \| TGFB3 \| DISEASES 1958 \| EGR1 \| DISEASES 8161 \| COIL \| DISEASES 7291 \| TWIST1 \| DISEASES 3598 \| IL13RA2 \| DISEASES 5184 \| PEPD \| DISEASES 3581 \| IL9R \| DISEASES 970 \| CD70 \| DISEASES 718 \| C3 \| DISEASES 22913 \| RALY \| DISEASES 968 \| CD68 \| DISEASES 90459 \| ERI1 \| DISEASES 43849 \| KLK12 \| DISEASES 9518 \| GDF15 \| DISEASES 6737 \| TRIM21 \| DISEASES 6737 \| TRIM21 \| DISEASES 23225 \| NUP210 \| DISEASES 1401 \| CRP \| DISEASES 10955 \| SERINC3 \| DISEASES 1116 \| CHI3L1 \| DISEASES 1830 \| DSG3 \| DISEASES 3357 \| HTR2B \| DISEASES 3569 \| IL6 \| DISEASES 640 \| BLK \| DISEASES 170679 \| PSORS1C1 \| DISEASES 10068 \| IL18BP \| DISEASES 7057 \| THBS1 \| DISEASES 79172 \| CENPO \| DISEASES 6741 \| SSB \| DISEASES 6741 \| SSB \| DISEASES 64131 \| XYLT1 \| DISEASES 7450 \| VWF \| DISEASES 5159 \| PDGFRB \| DISEASES 9043 \| SPAG9 \| DISEASES 4481 \| MSR1 \| DISEASES 4092 \| SMAD7 \| DISEASES 4087 \| SMAD2 \| DISEASES 9739 \| SETD1A \| DISEASES 55816 \| DOK5 \| DISEASES 64377 \| CHST8 \| DISEASES 495 \| ATP4A \| DISEASES 7077 \| TIMP2 \| DISEASES 5595 \| MAPK3 \| DISEASES 50507 \| NOX4 \| DISEASES 3552 \| IL1A \| DISEASES 3553 \| IL1B \| DISEASES 55717 \| WDR11 \| DISEASES 55717 \| WDR11 \| DISEASES 6403 \| SELP \| DISEASES 89884 \| LHX4 \| DISEASES 3791 \| KDR \| DISEASES 943 \| TNFRSF8 \| DISEASES 4162 \| MCAM \| DISEASES 941 \| CD80 \| DISEASES 2247 \| FGF2 \| DISEASES 1356 \| CP \| DISEASES 2355 \| FOSL2 \| DISEASES 3383 \| ICAM1 \| DISEASES 3383 \| ICAM1 \| DISEASES 3827 \| KNG1 \| DISEASES 1462 \| VCAN \| DISEASES 1062 \| CENPE \| DISEASES 23534 \| TNPO3 \| DISEASES 7472 \| WNT2 \| DISEASES 311 \| ANXA11 \| DISEASES 5286 \| PIK3C2A \| DISEASES 3373 \| HYAL1 \| DISEASES 23761 \| PISD \| DISEASES 1009 \| CDH11 \| DISEASES 3394 \| IRF8 \| DISEASES 3454 \| IFNAR1 \| DISEASES 150094 \| SIK1 \| DISEASES 207 \| AKT1 \| DISEASES 57333 \| RCN3 \| DISEASES 2212 \| FCGR2A \| DISEASES 3930 \| LBR \| DISEASES 5972 \| REN \| DISEASES 5972 \| REN \| DISEASES 388 \| RHOB \| DISEASES 185 \| AGTR1 \| DISEASES 8795 \| TNFRSF10B \| DISEASES 8795 \| TNFRSF10B \| DISEASES 3439 \| IFNA1 \| DISEASES 133 \| ADM \| DISEASES 6749 \| SSRP1 \| DISEASES 90952 \| ESAM \| DISEASES 10666 \| CD226 \| DISEASES 3606 \| IL18 \| DISEASES 7292 \| TNFSF4 \| DISEASES 2321 \| FLT1 \| DISEASES 5352 \| PLOD2 \| DISEASES 1360 \| CPB1 \| DISEASES 64946 \| CENPH \| DISEASES 7070 \| THY1 \| DISEASES 83648 \| FAM167A \| DISEASES 79895 \| ATP8B4 \| DISEASES 11197 \| WIF1 \| DISEASES 5468 \| PPARG \| DISEASES 3815 \| KIT \| DISEASES 4091 \| SMAD6 \| DISEASES 50848 \| F11R \| DISEASES 3588 \| IL10RB \| DISEASES 1636 \| ACE \| DISEASES 1636 \| ACE \| DISEASES 115650 \| TNFRSF13C \| DISEASES 5739 \| PTGIR \| DISEASES 2220 \| FCN2 \| DISEASES 115653 \| KIR3DL3 \| DISEASES 6294 \| SAFB \| DISEASES 51043 \| ZBTB7B \| DISEASES 729230 \| CCR2 \| DISEASES 6352 \| CCL5 \| DISEASES 10158 \| PDZK1IP1 \| DISEASES 6006 \| RHCE \| DISEASES 7412 \| VCAM1 \| DISEASES 7412 \| VCAM1 \| DISEASES 2215 \| FCGR3B \| DISEASES 11167 \| FSTL1 \| DISEASES 10109 \| ARPC2 \| DISEASES 10109 \| ARPC2 \| DISEASES 213 \| ALB \| DISEASES 5473 \| PPBP \| DISEASES 5473 \| PPBP \| DISEASES 5196 \| PF4 \| DISEASES 1230 \| CCR1 \| DISEASES 308 \| ANXA5 \| DISEASES 7098 \| TLR3 \| DISEASES 1278 \| COL1A2 \| DISEASES 1278 \| COL1A2 \| DISEASES 4846 \| NOS3 \| DISEASES 79841 \| AGBL2 \| DISEASES 4314 \| MMP3 \| DISEASES 7480 \| WNT10B \| DISEASES 3816 \| KLK1 \| DISEASES 5617 \| PRL \| DISEASES 140838 \| NANP \| DISEASES 7343 \| UBTF \| DISEASES 7343 \| UBTF \| DISEASES 169044 \| COL22A1 \| DISEASES 3688 \| ITGB1 \| DISEASES 1493 \| CTLA4 \| DISEASES 1493 \| CTLA4 \| DISEASES 1281 \| COL3A1 \| DISEASES 3596 \| IL13 \| DISEASES 3627 \| CXCL10 \| DISEASES 1469 \| CST1 \| DISEASES 3575 \| IL7R \| DISEASES 56246 \| MRAP \| DISEASES 6383 \| SDC2 \| DISEASES 54205 \| CYCS \| DISEASES 54205 \| CYCS \| DISEASES 2147 \| F2 \| DISEASES 5340 \| PLG \| DISEASES 79834 \| PEAK1 \| DISEASES 947 \| CD34 \| DISEASES 10534 \| SSSCA1 \| DISEASES 55584 \| CHRNA9 \| DISEASES 4179 \| CD46 \| DISEASES 285 \| ANGPT2 \| DISEASES 1909 \| EDNRA \| DISEASES 1909 \| EDNRA \| DISEASES 283316 \| CD163L1 \| DISEASES 79966 \| SCD5 \| DISEASES 23129 \| PLXND1 \| DISEASES 4233 \| MET \| DISEASES 122664 \| TPPP2 \| DISEASES 54913 \| RPP25 \| DISEASES 10318 \| TNIP1 \| DISEASES 4691 \| NCL \| DISEASES 79932 \| KIAA0319L \| DISEASES 4684 \| NCAM1 \| DISEASES 8851 \| CDK5R1 \| DISEASES 7173 \| TPO \| DISEASES 3579 \| CXCR2 \| DISEASES 56892 \| C8orf4 \| DISEASES 8834 \| TMEM11 \| DISEASES 80381 \| CD276 \| DISEASES 55024 \| BANK1 \| DISEASES 55024 \| BANK1 \| DISEASES 23765 \| IL17RA \| DISEASES 6863 \| TAC1 \| DISEASES 2149 \| F2R \| DISEASES 2149 \| F2R \| DISEASES 5345 \| SERPINF2 \| DISEASES 3039 \| HBA1 \| DISEASES 4312 \| MMP1 \| DISEASES 4312 \| MMP1 \| DISEASES 57621 \| ZBTB2 \| DISEASES 2535 \| FZD2 \| DISEASES 23362 \| PSD3 \| DISEASES 85302 \| FBF1 \| DISEASES 29091 \| STXBP6 \| DISEASES 2200 \| FBN1 \| DISEASES 2200 \| FBN1 \| DISEASES 4843 \| NOS2 \| DISEASES 7485 \| WRB \| DISEASES 8784 \| TNFRSF18 \| DISEASES 6667 \| SP1 \| DISEASES 3665 \| IRF7 \| DISEASES 55803 \| ADAP2 \| DISEASES 5155 \| PDGFB \| DISEASES 6401 \| SELE \| DISEASES 6401 \| SELE \| DISEASES 942 \| CD86 \| DISEASES 8338 \| HIST2H2AC \| DISEASES 162540 \| SPPL2C \| DISEASES 4088 \| SMAD3 \| DISEASES 2152 \| F3 \| DISEASES 2301 \| FOXE3 \| DISEASES 10623 \| POLR3C \| DISEASES 1058 \| CENPA \| DISEASES 1058 \| CENPA \| DISEASES 1908 \| EDN3 \| DISEASES 1908 \| EDN3 \| DISEASES 9138 \| ARHGEF1 \| DISEASES 9138 \| ARHGEF1 \| DISEASES 55166 \| CENPQ \| DISEASES 3363 \| HTR7 \| DISEASES 50615 \| IL21R \| DISEASES 51338 \| MS4A4A \| DISEASES 7430 \| EZR \| DISEASES 3266 \| ERAS \| DISEASES 23076 \| RRP1B \| DISEASES 857 \| CAV1 \| DISEASES 5329 \| PLAUR \| DISEASES 3117 \| HLA-DQA1 \| DISEASES 3117 \| HLA-DQA1 \| DISEASES 6129 \| RPL7 \| DISEASES 85480 \| TSLP \| DISEASES 4602 \| MYB \| DISEASES 4602 \| MYB \| DISEASES 3329 \| HSPD1 \| DISEASES 93 \| ACVR2B \| DISEASES 6614 \| SIGLEC1 \| DISEASES 4089 \| SMAD4 \| DISEASES 6134 \| RPL10 \| DISEASES 2359 \| FPR3 \| DISEASES 7518 \| XRCC4 \| DISEASES 6672 \| SP100 \| DISEASES 55975 \| KLHL7 \| DISEASES 1003 \| CDH5 \| DISEASES 3605 \| IL17A \| DISEASES 1499 \| CTNNB1 \| DISEASES 9045 \| RPL14 \| DISEASES 89790 \| SIGLEC10 \| DISEASES 6275 \| S100A4 \| DISEASES 5154 \| PDGFA \| DISEASES 4948 \| OCA2 \| DISEASES 54898 \| ELOVL2 \| DISEASES 3181 \| HNRNPA2B1 \| DISEASES 2335 \| FN1 \| DISEASES 79837 \| PIP4K2C \| DISEASES 8654 \| PDE5A \| DISEASES 9815 \| GIT2 \| DISEASES 80781 \| COL18A1 \| DISEASES 355 \| FAS \| DISEASES 3240 \| HP \| DISEASES 54899 \| PXK \| DISEASES 55544 \| RBM38 \| DISEASES 3683 \| ITGAL \| DISEASES 3663 \| IRF5 \| DISEASES 6714 \| SRC \| DISEASES 53841 \| CDHR5 \| DISEASES 6775 \| STAT4 \| DISEASES 2213 \| FCGR2B \| DISEASES 1902 \| LPAR1 \| DISEASES 7048 \| TGFBR2 \| DISEASES 9332 \| CD163 \| DISEASES 1786 \| DNMT1 \| DISEASES 145864 \| HAPLN3 \| DISEASES 26191 \| PTPN22 \| DISEASES 3123 \| HLA-DRB1 \| DISEASES 5697 \| PYY \| DISEASES 4478 \| MSN \| DISEASES 5599 \| MAPK8 \| DISEASES 2993 \| GYPA \| DISEASES 7150 \| TOP1 \| DISEASES 7150 \| TOP1 \| DISEASES 919 \| CD247 \| DISEASES 4283 \| CXCL9 \| DISEASES 51734 \| MSRB1 \| DISEASES 5867 \| RAB4A \| DISEASES 168002 \| DACT2 \| DISEASES 7042 \| TGFB2 \| DISEASES 1063 \| CENPF \| DISEASES 7432 \| VIP \| DISEASES 59349 \| KLHL12 \| DISEASES 7139 \| TNNT2 \| DISEASES 5788 \| PTPRC \| DISEASES 6738 \| TROVE2 \| DISEASES 462 \| SERPINC1 \| DISEASES 2214 \| FCGR3A \| DISEASES 1490 \| CTGF \| DISEASES 1490 \| CTGF \| DISEASES 9447 \| AIM2 \| DISEASES 3428 \| IFI16 \| DISEASES 154075 \| SAMD3 \| DISEASES 149628 \| PYHIN1 \| DISEASES 149628 \| PYHIN1 \| DISEASES 4332 \| MNDA \| DISEASES 4332 \| MNDA \| DISEASES 911 \| CD1C \| DISEASES 4582 \| MUC1 \| DISEASES 8038 \| ADAM12 \| DISEASES 6278 \| S100A7 \| DISEASES 6278 \| S100A7 \| DISEASES 8349 \| HIST2H2BE \| DISEASES 8337 \| HIST2H2AA3 \| DISEASES 965 \| CD58 \| DISEASES 4803 \| NGF \| DISEASES 3654 \| IRAK1 \| DISEASES 959 \| CD40LG \| DISEASES 10561 \| IFI44 \| DISEASES 27329 \| ANGPTL3 \| DISEASES 3725 \| JUN \| DISEASES 3597 \| IL13RA1 \| DISEASES 1757 \| SARDH \| DISEASES 11093 \| ADAMTS13 \| DISEASES 6130 \| RPL7A \| DISEASES 7422 \| VEGFA \| DISEASES 958 \| CD40 \| DISEASES 6441 \| SFTPD \| DISEASES 4318 \| MMP9 \| DISEASES 25 \| ABL1 \| DISEASES 1907 \| EDN2 \| DISEASES 6385 \| SDC4 \| DISEASES 10269 \| ZMPSTE24 \| DISEASES 2491 \| CENPI \| DISEASES 2022 \| ENG \| DISEASES 2833 \| CXCR3 \| DISEASES 7099 \| TLR4 \| DISEASES 7580 \| ZNF32 \| DISEASES 659 \| BMPR2 \| DISEASES 3339 \| HSPG2 \| DISEASES 3339 \| HSPG2 \| DISEASES 1290 \| COL5A2 \| DISEASES 3118 \| HLA-DQA2 \| DISEASES 3127 \| HLA-DRB5 \| DISEASES 7046 \| TGFBR1 \| DISEASES 7046 \| TGFBR1 \| DISEASES 401541 \| CENPP \| DISEASES 3055 \| HCK \| DISEASES 10673 \| TNFSF13B \| DISEASES 199 \| AIF1 \| DISEASES 50943 \| FOXP3 \| DISEASES 7133 \| TNFRSF1B \| DISEASES 1041 \| CDSN \| DISEASES 4879 \| NPPB \| DISEASES 3105 \| HLA-A \| DISEASES 3105 \| HLA-A \| DISEASES 5394 \| EXOSC10 \| DISEASES 5394 \| EXOSC10 \| DISEASES 7056 \| THBD \| DISEASES 7056 \| THBD \| DISEASES 1910 \| EDNRB \| DISEASES 3274 \| HRH2 \| DISEASES 2512 \| FTL \| DISEASES 688 \| KLF5 \| DISEASES 8718 \| TNFRSF25 \| DISEASES 8718 \| TNFRSF25 \| DISEASES 10557 \| RPP38 \| DISEASES 441376 \| AARD \| DISEASES 51182 \| HSPA14 \| DISEASES 6354 \| CCL7 \| DISEASES 1906 \| EDN1 \| DISEASES 1906 \| EDN1 \| DISEASES 5393 \| EXOSC9 \| DISEASES 10631 \| POSTN \| DISEASES 1059 \| CENPB \| DISEASES 1059 \| CENPB \| DISEASES 3559 \| IL2RA \| DISEASES 7010 \| TEK \| DISEASES 10799 \| RPP40 \| DISEASES 51374 \| ATRAID \| DISEASES 51374 \| ATRAID \| DISEASES 3456 \| IFNB1 \| DISEASES 51284 \| TLR7 \| DISEASES 11168 \| PSIP1 \| DISEASES 3486 \| IGFBP3 \| DISEASES 90865 \| IL33 \| DISEASES 339965 \| CCDC158 \| DISEASES 94 \| ACVRL1 \| DISEASES 91522 \| COL23A1 \| DISEASES 163126 \| EID2 \| DISEASES 83942 \| TSSK1B \| DISEASES 122618 \| PLD4 \| DISEASES 2591 \| GALNT3 \| DISEASES 26130 \| GAPVD1 \| DISEASES 79842 \| ZBTB3 \| DISEASES 28964 \| GIT1 \| DISEASES 6696 \| SPP1 \| DISEASES 6387 \| CXCL12 \| DISEASES 831 \| CAST \| DISEASES 3676 \| ITGA4 \| DISEASES 7106 \| TSPAN4 \| DISEASES 594857 \| NPS \| DISEASES 4599 \| MX1 \| DISEASES 2887 \| GRB10 \| DISEASES 1305 \| COL13A1 \| DISEASES 3119 \| HLA-DQB1 \| DISEASES 3119 \| HLA-DQB1 \| DISEASES 23515 \| MORC3 \| DISEASES 3803 \| KIR2DL2 \| DISEASES 23308 \| ICOSLG \| DISEASES 7852 \| CXCR4 \| DISEASES 3384 \| ICAM2 \| DISEASES 4295 \| MLN \| DISEASES 10556 \| RPP30 \| DISEASES 3120 \| HLA-DQB2 \| DISEASES 3120 \| HLA-DQB2 \| DISEASES 11277 \| TREX1 \| DISEASES 136371 \| ASB10 \| DISEASES 3113 \| HLA-DPA1 \| DISEASES 1438 \| CSF2RA \| DISEASES 720 \| C4A \| DISEASES 720 \| C4A \| DISEASES 6660 \| SOX5 \| DISEASES 960 \| CD44 \| DISEASES 3702 \| ITK \| DISEASES 7124 \| TNF \| DISEASES 3109 \| HLA-DMB \| DISEASES 2313 \| FLI1 \| DISEASES 6559 \| SLC12A3 \| DISEASES 29970 \| SCHIP1 \| DISEASES 3115 \| HLA-DPB1 \| DISEASES 3115 \| HLA-DPB1 \| DISEASES 9266 \| CYTH2 \| DISEASES 23228 \| PLCL2 \| DISEASES 834 \| CASP1 \| DISEASES 3586 \| IL10 \| DISEASES 151827 \| LRRC34 \| DISEASES 8842 \| PROM1 \| DISEASES 721 \| C4B \| DISEASES 721 \| C4B \| DISEASES 6168 \| RPL37A \| DISEASES 11164 \| NUDT5 \| DISEASES 813 \| CALU \| DISEASES 6949 \| TCOF1 \| DISEASES 51428 \| DDX41 \| DISEASES 55819 \| RNF130 \| DISEASES 727897 \| MUC5B \| DISEASES 930 \| CD19 \| DISEASES 3684 \| ITGAM \| DISEASES 283450 \| HECTD4 \| DISEASES 5228 \| PGF \| DISEASES 8742 \| TNFSF12 \| DISEASES 101 \| ADAM8 \| DISEASES 22861 \| NLRP1 \| DISEASES 6625 \| SNRNP70 \| DISEASES 6625 \| SNRNP70 \| DISEASES 102723508 \| KANTR \| DISEASES 79104 \| MEG8 \| DISEASES 692084 \| SNORD13 \| DISEASES 9304 \| SNORD22 \| DISEASES 9383 \| TSIX \| DISEASES
Locus	(Waiting for update.)

Disease ID	59
Disease	systemic scleroderma
Integrated Phenotype	(Waiting for update.)
Text Mined Phenotype	HPO \| Name \| Sentences' Count(Total Phenotypes:10) HP:0002092 \| Pulmonary artery hypertension \| 2 HP:0100512 \| Vitamin D deficiency \| 1 HP:0002352 \| Leukoencephalopathy \| 1 HP:0002063 \| Muscle rigidity \| 1 HP:0006859 \| Posterior leukoencephalopathy \| 1 HP:0000822 \| Hypertension \| 1 HP:0007618 \| Subcutaneous calcification \| 1 HP:0002202 \| Pleural effusion \| 1 HP:0002716 \| Lymph node hyperplasia \| 1 HP:0100614 \| Muscle inflammation \| 1

Disease ID	59
Disease	systemic scleroderma
Manually Symptom	UMLS \| Name(Total Manually Symptoms:51) C1963220 \| pulmonary hypertension C1963198 \| pancreatitis C1963138 \| hypertension C1956391 \| temporal arteritis C1879286 \| bundle branch block C1619734 \| pulmonary arterial hypertension C1555769 \| pulmonary disease C1510420 \| cavities C1402315 \| vascular lesions C1400513 \| transmural myocardial infarction C1393529 \| vascular complications C1335437 \| plexopathy C1282916 \| secondary raynaud's phenomenon C1000483 \| anemia C0947912 \| myasthenia C0878544 \| cardiomyopathy C0748159 \| pulmonary involvement C0728936 \| circulatory disorders C0702102 \| arthritis mutilans C0545044 \| acrokeratoelastoidosis C0410000 \| overlap syndrome C0267073 \| dysphagia lusoria C0263628 \| tumoral calcinosis C0206676 \| pulmonary adenomatosis C0162835 \| depigmentation C0155339 \| brown syndrome C0152025 \| polyneuropathy C0151517 \| complete atrioventricular block C0042373 \| vascular disorders C0041296 \| tuberculosis C0038358 \| gastric ulcers C0037284 \| skin lesions C0037284 \| skin lesion C0034735 \| raynaud's syndrome C0034735 \| raynaud's phenomenon C0034734 \| raynaud's disease C0034069 \| pulmonary fibrosis C0030270 \| pancarditis C0027765 \| neurological disorders C0024633 \| mallory-weiss syndrome C0024115 \| lung disease C0023223 \| lower extremity ulcer C0022658 \| nephropathy C0022658 \| kidney diseases C0022408 \| arthropathy C0018799 \| heart disease C0017675 \| glossitis C0015458 \| facial hemiatrophy C0015397 \| eye diseases C0014306 \| enophthalmos C0006663 \| calcinosis
Text Mined Symptom	UMLS \| Name \| Sentences' Count(Total Symptoms:4) C0020538 \| hypertension \| 1 C0748159 \| pulmonary involvement \| 1 C0410000 \| overlap syndrome \| 1 C0020542 \| pulmonary hypertension \| 1

Manually Genotype(Total Text Mining Genotypes:0)
(Waiting for update.)

All Snps(Total Genotypes:120)
snpId	pubmedId	geneId	geneSymbol	diseaseId	sourceId	sentence	score	Year	geneSymbol_dbSNP	CHROMOSOME	POS	REF	ALT
rs10036748	22694930	10318	TNIP1	umls:C0036421	BeFree	The T allele of rs10036748 in the TNIP1 gene is the minor protective allele for asthma but the minor or major risk allele for systemic lupus erythematosus and systemic sclerosis in non-Hispanic white or Chinese subjects, respectively.	0.240814326	2012	TNIP1	5	151078585	C	T
rs10488631	21750679	23534	TNPO3	umls:C0036421	GWASCAT	Genome-wide scan identifies TNIP1, PSORS1C1, and RHOB as novel risk loci for systemic sclerosis.	0.127372538	2011	TNPO3	7	128954129	T	C
rs10488631	20383147	3663	IRF5	umls:C0036421	GAD	[Additionally, we confirm and firmly establish the role of the MHC (P = 2.31 x 10(-18)), IRF5 (P = 1.86 x 10(-13)) and STAT4 (P = 3.37 x 10(-9)) gene regions as SSc genetic risk factors.]	0.14309376	2010	TNPO3	7	128954129	T	C
rs10488631	21779181	3663	IRF5	umls:C0036421	GAD	[Identification of novel genetic markers associated with clinical phenotypes of systemic sclerosis through a genome-wide association strategy.]	0.14309376	2011	TNPO3	7	128954129	T	C
rs10488631	22440820	6775	STAT4	umls:C0036421	BeFree	Five single nucleotide polymorphisms, IRF5 (rs10488631, rs12537284, rs4728142), STAT4 (rs3821236), CD247 (rs2056626) reached genome-wide significance in the SSc-GWAS and were examined in the current study.	0.257188052	2012	TNPO3	7	128954129	T	C
rs10488631	20383147	23534	TNPO3	umls:C0036421	GWASCAT	Genome-wide association study of systemic sclerosis identifies CD247 as a new susceptibility locus.	0.127372538	2010	TNPO3	7	128954129	T	C
rs10488631	21779181	23534	TNPO3	umls:C0036421	GAD	[Identification of novel genetic markers associated with clinical phenotypes of systemic sclerosis through a genome-wide association strategy.]	0.127372538	2011	TNPO3	7	128954129	T	C
rs10488631	20383147	23534	TNPO3	umls:C0036421	GAD	[Genome-wide association study of systemic sclerosis identifies CD247 as a new susceptibility locus.]	0.127372538	2010	TNPO3	7	128954129	T	C
rs10488631	21779181	23534	TNPO3	umls:C0036421	GWASCAT	Identification of novel genetic markers associated with clinical phenotypes of systemic sclerosis through a genome-wide association strategy.	0.127372538	2011	TNPO3	7	128954129	T	C
rs10488631	22440820	919	CD247	umls:C0036421	BeFree	Five single nucleotide polymorphisms, IRF5 (rs10488631, rs12537284, rs4728142), STAT4 (rs3821236), CD247 (rs2056626) reached genome-wide significance in the SSc-GWAS and were examined in the current study.	0.24554839	2012	TNPO3	7	128954129	T	C
rs10516487	19877059	55024	BANK1	umls:C0036421	BeFree	To determine whether the functional BANK1 variants rs3733197 and rs10516487 are associated with systemic sclerosis (SSc) in 2 European Caucasian populations and to investigate the putative gene-gene interactions between BANK1 and IRF5 as well as STAT4.	0.003724241	2009	BANK1	4	101829919	G	T,A
rs10516487	19877059	6775	STAT4	umls:C0036421	BeFree	To determine whether the functional BANK1 variants rs3733197 and rs10516487 are associated with systemic sclerosis (SSc) in 2 European Caucasian populations and to investigate the putative gene-gene interactions between BANK1 and IRF5 as well as STAT4.	0.257188052	2009	BANK1	4	101829919	G	T,A
rs10516487	19877059	3663	IRF5	umls:C0036421	BeFree	To determine whether the functional BANK1 variants rs3733197 and rs10516487 are associated with systemic sclerosis (SSc) in 2 European Caucasian populations and to investigate the putative gene-gene interactions between BANK1 and IRF5 as well as STAT4.	0.14309376	2009	BANK1	4	101829919	G	T,A
rs1059702	23444193	3654	IRAK1	umls:C0036421	BeFree	On the other hand, IRAK1 rs1059702 was consistently associated with presence of pulmonary fibrosis (PF), because statistical significance was observed when comparing SSc patients PF+ versus controls (PFDR=0.039, OR=1.30, 95% CI 1.07 to 1.58) and SSc patients PF+ versus SSc patients PF- (p=0.025, OR=1.26, 95% CI 1.03 to 1.55).	0.000542884	2014	IRAK1	X	154018741	A	G
rs10946216	23983073	128367	OR10X1	umls:C0036421	BeFree	Combined analyses revealed an association between the rs10946216 SNP and SSc susceptibility (odds ratio [OR] 1.13, 95% confidence interval [95% CI] 1.05-1.21, adjusted P [P(adj)] = 0.026).	0.000271442	2013	CCR6	6	167125409	T	C
rs11047102	21779181	6660	SOX5	umls:C0036421	GAD	[We have identified three new non-HLA genes (IRF8, GRB10, and SOX5) associated with SSc clinical and auto-antibody subgroups.]	0.122638474	2011	SOX5	12	23793212	C	T
rs11047102	21779181	6660	SOX5	umls:C0036421	GWASCAT	We have identified three new non-HLA genes (IRF8, GRB10, and SOX5) associated with SSc clinical and auto-antibody subgroups.	0.122638474	2011	SOX5	12	23793212	C	T
rs11171747	21779181	84872	ZC3H10	umls:C0036421	GAD	[Identification of novel genetic markers associated with clinical phenotypes of systemic sclerosis through a genome-wide association strategy.]	0.002367032	2011	NA	12	56124624	T	G
rs1130866	18263595	6439	SFTPB	umls:C0036421	BeFree	Genetic polymorphisms in the surfactant proteins in systemic sclerosis in Japanese: T/T genotype at 1580 C/T (Thr131Ile) in the SP-B gene reduces the risk of interstitial lung disease.	0.005362824	2008	SFTPB	2	85666618	G	A
rs1133906	23740937	219285	SAMD9L	umls:C0036421	GWASCAT	A systemic sclerosis and systemic lupus erythematosus pan-meta-GWAS reveals new shared susceptibility loci.	0.12	2014	SAMD9L	7	93135669	C	T
rs11642873	21779181	3394	IRF8	umls:C0036421	GAD	[We have identified three new non-HLA genes (IRF8, GRB10, and SOX5) associated with SSc clinical and auto-antibody subgroups.]	0.002909916	2011	NA	16	85958099	A	C
rs11860650	23740937	3684	ITGAM	umls:C0036421	GWASCAT	A systemic sclerosis and systemic lupus erythematosus pan-meta-GWAS reveals new shared susceptibility loci.	0.120542884	2014	ITGAM	16	31315385	C	T
rs12537284	22440820	919	CD247	umls:C0036421	BeFree	Five single nucleotide polymorphisms, IRF5 (rs10488631, rs12537284, rs4728142), STAT4 (rs3821236), CD247 (rs2056626) reached genome-wide significance in the SSc-GWAS and were examined in the current study.	0.24554839	2012	NA	7	129077852	G	A
rs12537284	22440820	6775	STAT4	umls:C0036421	BeFree	Five single nucleotide polymorphisms, IRF5 (rs10488631, rs12537284, rs4728142), STAT4 (rs3821236), CD247 (rs2056626) reached genome-wide significance in the SSc-GWAS and were examined in the current study.	0.257188052	2012	NA	7	129077852	G	A
rs12540874	21779181	2887	GRB10	umls:C0036421	GAD	[We have identified three new non-HLA genes (IRF8, GRB10, and SOX5) associated with SSc clinical and auto-antibody subgroups.]	0.122638474	2011	GRB10	7	50597225	A	G
rs12540874	21779181	2887	GRB10	umls:C0036421	GWASCAT	We have identified three new non-HLA genes (IRF8, GRB10, and SOX5) associated with SSc clinical and auto-antibody subgroups.	0.122638474	2011	GRB10	7	50597225	A	G
rs13239597	23740937	286016	TPI1P2	umls:C0036421	GWASCAT	A systemic sclerosis and systemic lupus erythematosus pan-meta-GWAS reveals new shared susceptibility loci.	0.12	2014	TNPO3;TPI1P2	7	129055929	C	A
rs13239597	23740937	23534	TNPO3	umls:C0036421	GWASCAT	A systemic sclerosis and systemic lupus erythematosus pan-meta-GWAS reveals new shared susceptibility loci.	0.127372538	2014	TNPO3;TPI1P2	7	129055929	C	A
rs1535001	23740937	23294	ANKS1A	umls:C0036421	GWASCAT	A systemic sclerosis and systemic lupus erythematosus pan-meta-GWAS reveals new shared susceptibility loci.	0.12	2014	ANKS1A	6	34959503	A	G
rs1635852	23740937	221895	JAZF1	umls:C0036421	GWASCAT	With these, we add three (KIAA0319L, PXK and JAZF1) and one (KIAA0319L) new susceptibility loci for SSc and SLE, respectively, increasing significantly the knowledge of the genetic basis of autoimmunity.	0.120271442	2014	JAZF1	7	28149792	T	C
rs1799983	17634663	4846	NOS3	umls:C0036421	BeFree	We investigated haemorheological variables in patients with idiopathic sudden sensorineural hearing loss (ISSHL), retinal vein occlusion (RVO) and systemic sclerosis (SSc), as possible models of microvascular damage, and their relationship with eNOS gene T-786C, G894T and 4a/4b polymorphisms.	0.01654548	2007	NOS3	7	150999023	T	G
rs1799983	15530459	4846	NOS3	umls:C0036421	BeFree	Our results indicate that eNOS (G894T) and p22(phox) (C242T) polymorphisms do not influence susceptibility to and the course of systemic sclerosis.	0.01654548	2004	NOS3	7	150999023	T	G
rs1799983	12015245	4846	NOS3	umls:C0036421	BeFree	High prevalence of polymorphisms of angiotensin-converting enzyme (I/D) and endothelial nitric oxide synthase (Glu298Asp) in patients with systemic sclerosis.	0.01654548	2002	NOS3	7	150999023	T	G
rs1799983	12015245	1636	ACE	umls:C0036421	BeFree	High prevalence of polymorphisms of angiotensin-converting enzyme (I/D) and endothelial nitric oxide synthase (Glu298Asp) in patients with systemic sclerosis.	0.017088363	2002	NOS3	7	150999023	T	G
rs1800795	23027890	79017	GGCT	umls:C0036421	BeFree	In the IL6 allelic combination analyses, the GGC allelic combination rs2069827-rs1800795-rs2069840 showed an association with overall SSc (Bonferroni p = 0.016, OR 1.13, 95% CI 1.04-1.23).	0.000271442	2012	IL6;LOC541472	7	22727026	C	G
rs2004640	21149496	6775	STAT4	umls:C0036421	BeFree	Logistic regression analysis showed an additive effect of IRF5 rs2004640, STAT4 rs7574865 and NLRP1 rs8182352 risk alleles on SSc-related FA.	0.257188052	2011	IRF5	7	128938247	T	G
rs2004640	21149496	3663	IRF5	umls:C0036421	BeFree	Logistic regression analysis showed an additive effect of IRF5 rs2004640, STAT4 rs7574865 and NLRP1 rs8182352 risk alleles on SSc-related FA.	0.14309376	2011	IRF5	7	128938247	T	G
rs2004640	19116937	3663	IRF5	umls:C0036421	BeFree	Association between the IRF5 rs2004640 functional polymorphism and systemic sclerosis: a new perspective for pulmonary fibrosis.	0.14309376	2009	IRF5	7	128938247	T	G
rs2004640	19116937	3663	IRF5	umls:C0036421	GAD	[Association between the IRF5 rs2004640 functional polymorphism and systemic sclerosis: a new perspective for pulmonary fibrosis.]	0.14309376	2009	IRF5	7	128938247	T	G
rs2004640	25572744	472	ATM	umls:C0036421	BeFree	SSc patients of Han Chinese showed increased homozygous TT genotype of the rs2004640 (p = 0.027, odds ratio (OR) = 1.4, CI =1.03-1.93), which was significantly associated with pulmonary fibrosis of SSc and ATA-positive SSc of Han Chinese.	0.000542884	2015	IRF5	7	128938247	T	G
rs2004640	25572744	3663	IRF5	umls:C0036421	BeFree	Association of the IRF5 SNP rs2004640 with systemic sclerosis in Han Chinese.	0.14309376	2015	IRF5	7	128938247	T	G
rs2056626	21779181	919	CD247	umls:C0036421	GAD	[Identification of novel genetic markers associated with clinical phenotypes of systemic sclerosis through a genome-wide association strategy.]	0.24554839	2011	CD247	1	167451188	T	G
rs2056626	21750679	919	CD247	umls:C0036421	GWASCAT	Genome-wide scan identifies TNIP1, PSORS1C1, and RHOB as novel risk loci for systemic sclerosis.	0.24554839	2011	CD247	1	167451188	T	G
rs2056626	20383147	919	CD247	umls:C0036421	GAD	[Genome-wide association study of systemic sclerosis identifies CD247 as a new susceptibility locus.]	0.24554839	2010	CD247	1	167451188	T	G
rs2056626	22440820	919	CD247	umls:C0036421	BeFree	Five single nucleotide polymorphisms, IRF5 (rs10488631, rs12537284, rs4728142), STAT4 (rs3821236), CD247 (rs2056626) reached genome-wide significance in the SSc-GWAS and were examined in the current study.	0.24554839	2012	CD247	1	167451188	T	G
rs2056626	22440820	6775	STAT4	umls:C0036421	BeFree	Five single nucleotide polymorphisms, IRF5 (rs10488631, rs12537284, rs4728142), STAT4 (rs3821236), CD247 (rs2056626) reached genome-wide significance in the SSc-GWAS and were examined in the current study.	0.257188052	2012	CD247	1	167451188	T	G
rs2056626	20383147	919	CD247	umls:C0036421	GWASCAT	Genome-wide association study of systemic sclerosis identifies CD247 as a new susceptibility locus.	0.24554839	2010	CD247	1	167451188	T	G
rs2069827	23027890	79017	GGCT	umls:C0036421	BeFree	In the IL6 allelic combination analyses, the GGC allelic combination rs2069827-rs1800795-rs2069840 showed an association with overall SSc (Bonferroni p = 0.016, OR 1.13, 95% CI 1.04-1.23).	0.000271442	2012	IL6;LOC541472	7	22725837	G	T
rs2069840	23027890	79017	GGCT	umls:C0036421	BeFree	In the IL6 allelic combination analyses, the GGC allelic combination rs2069827-rs1800795-rs2069840 showed an association with overall SSc (Bonferroni p = 0.016, OR 1.13, 95% CI 1.04-1.23).	0.000271442	2012	IL6;LOC541472	7	22728953	C	G
rs2176082	23740937	54899	PXK	umls:C0036421	GWASCAT	With these, we add three (KIAA0319L, PXK and JAZF1) and one (KIAA0319L) new susceptibility loci for SSc and SLE, respectively, increasing significantly the knowledge of the genetic basis of autoimmunity.	0.120542884	2014	PXK	3	58345459	G	A
rs2228044	22742541	3569	IL6	umls:C0036421	BeFree	We aimed to investigate whether the functional genetic variants rs8192284 and rs2228044 previously associated with several autoimmune diseases, located within the IL-6 receptor (IL-6R) subunits IL6R and IL6ST genes, respectively, are involved in the susceptibility to SSc and/or its major clinical subphenotypes.	0.01198705	2012	IL6ST	5	55968325	C	G
rs2233287	21750679	10318	TNIP1	umls:C0036421	GWASCAT	Genome-wide scan identifies TNIP1, PSORS1C1, and RHOB as novel risk loci for systemic sclerosis.	0.240814326	2011	TNIP1	5	151060536	G	A
rs2275247	23740937	79932	KIAA0319L	umls:C0036421	GWASCAT	With these, we add three (KIAA0319L, PXK and JAZF1) and one (KIAA0319L) new susceptibility loci for SSc and SLE, respectively, increasing significantly the knowledge of the genetic basis of autoimmunity.	0.120271442	2014	KIAA0319L	1	35442850	T	C
rs2280381	23124809	3394	IRF8	umls:C0036421	BeFree	We also observed associations between SSc and rs6932056 in TNFAIP3 and rs2280381 in IRF8 (P = 0.0000095 and P = 0.0030, respectively), both of which displayed associations with SSc in a European population.	0.002909916	2013	NA	16	85985027	C	T
rs2280714	19479858	5079	PAX5	umls:C0036421	BeFree	All 3 SNPs were significantly associated with SSc, with the rs2280714 A allele having the strongest association (allele frequency P=0.0012, odds ratio 1.42 [95% confidence interval 1.15-1.75]).	0.000542884	2009	TNPO3	7	128954671	C	T
rs228648	22045841	10911	UTS2	umls:C0036421	BeFree	Association between Thr21Met and Ser89Asn polymorphisms of the urotensin II gene and systemic sclerosis.	0.000271442	2012	UTS2	1	7853370	G	A
rs2476601	17133608	26191	PTPN22	umls:C0036421	BeFree	Association of the PTPN22 R620W polymorphism with anti-topoisomerase I- and anticentromere antibody-positive systemic sclerosis.	0.009901391	2006	PTPN22;AP4B1-AS1	1	113834946	A	G
rs2476601	22704547	26191	PTPN22	umls:C0036421	BeFree	The PTPN22 C1858T variant as a risk factor for rheumatoid arthritis and systemic lupus erythematosus but not for systemic sclerosis in the Colombian population.	0.009901391	2012	PTPN22;AP4B1-AS1	1	113834946	A	G
rs2476601	16870103	26191	PTPN22	umls:C0036421	BeFree	Lack of association of the PTPN22 gene polymorphism R620W with systemic sclerosis.	0.009901391	2006	PTPN22;AP4B1-AS1	1	113834946	A	G
rs2476601	21688149	52	ACP1	umls:C0036421	BeFree	The aim of this study was to determine whether the functional protein tyrosine phosphatase nonreceptor 22 (PTPN22) C1858T polymorphism (rs2476601) confers susceptibility to systemic sclerosis (SSc) in different ethnic populations.	0.000542884	2012	PTPN22;AP4B1-AS1	1	113834946	A	G
rs2476601	23076337	26191	PTPN22	umls:C0036421	BeFree	By contrast, PTPN22 C1858T showed a negligible association with systemic sclerosis, celiac disease, multiple sclerosis, psoriasis, ankylosing spondylitis, pemphigus vulgaris, ulcerative colitis, primary sclerosing cholangitis, primary biliary cirrhosis, Crohn's disease and acute anterior uveitis.	0.009901391	2012	PTPN22;AP4B1-AS1	1	113834946	A	G
rs2476601	21688149	26191	PTPN22	umls:C0036421	BeFree	The association between the PTPN22 C1858T polymorphism and systemic sclerosis: a meta-analysis.	0.009901391	2012	PTPN22;AP4B1-AS1	1	113834946	A	G
rs25487	24488411	7518	XRCC4	umls:C0036421	BeFree	XRCC1 (rs: 25487) and XRCC4 (rs: 28360135) allele and genotype frequencies observed in patients with SSc were not significantly different from those observed in controls; however, the XRCC1 Arg399Gln allele was associated with increased DNA damage only in healthy controls and the XRCC4 Ile401Thr allele was associated with increased DNA damage in both patients and controls.	0.000271442	2014	XRCC1	19	43551574	T	C
rs310746	24401602	55584	CHRNA9	umls:C0036421	BeFree	We observed nominal associations for both PPARG rs310746 (PMH = 1.90 × 10⁻⁶, OR, 1.28) and CHRNA9 rs6832151 (PMH = 4.30 × 10⁻⁶, OR, 1.17) genetic variants with SSc in the first step of our study.	0.000271442	2013	NA	3	12218116	C	T
rs3129882	21779181	3122	HLA-DRA	umls:C0036421	GAD	[Identification of novel genetic markers associated with clinical phenotypes of systemic sclerosis through a genome-wide association strategy.]	0.122367032	2011	HLA-DRA	6	32441753	G	A
rs3129882	21779181	3122	HLA-DRA	umls:C0036421	GWASCAT	Identification of novel genetic markers associated with clinical phenotypes of systemic sclerosis through a genome-wide association strategy.	0.122367032	2011	HLA-DRA	6	32441753	G	A
rs3130573	21750679	170680	PSORS1C2	umls:C0036421	GWASCAT	Genome-wide scan identifies TNIP1, PSORS1C1, and RHOB as novel risk loci for systemic sclerosis.	0.12	2011	PSORS1C1;PSORS1C2	6	31138491	A	G
rs3130573	21750679	170679	PSORS1C1	umls:C0036421	GWASCAT	Genome-wide scan identifies TNIP1, PSORS1C1, and RHOB as novel risk loci for systemic sclerosis.	0.240542884	2011	PSORS1C1;PSORS1C2	6	31138491	A	G
rs344781	20967855	343170	OR14K1	umls:C0036421	BeFree	In the Italian cohort, the rs344781 G allele was associated with SSc-related digital ulceration (odds ratio [OR] 1.39), pulmonary arterial hypertension (PAH) (OR 1.81), anticentromere antibody (ACA) positivity (OR 1.45), and limited cutaneous SSc (lcSSc) (OR 1.37).	0.000271442	2011	PLAUR	19	43670636	C	T
rs344781	20967855	5329	PLAUR	umls:C0036421	GAD	[A genetic variation located in the promoter region of the UPAR (CD87) gene is associated with the vascular complications of systemic sclerosis.]	0.002909916	2011	PLAUR	19	43670636	C	T
rs3733197	19877059	6775	STAT4	umls:C0036421	BeFree	To determine whether the functional BANK1 variants rs3733197 and rs10516487 are associated with systemic sclerosis (SSc) in 2 European Caucasian populations and to investigate the putative gene-gene interactions between BANK1 and IRF5 as well as STAT4.	0.257188052	2009	BANK1	4	101918130	G	A
rs3733197	19877059	3663	IRF5	umls:C0036421	BeFree	To determine whether the functional BANK1 variants rs3733197 and rs10516487 are associated with systemic sclerosis (SSc) in 2 European Caucasian populations and to investigate the putative gene-gene interactions between BANK1 and IRF5 as well as STAT4.	0.14309376	2009	BANK1	4	101918130	G	A
rs3733197	19877059	55024	BANK1	umls:C0036421	BeFree	To determine whether the functional BANK1 variants rs3733197 and rs10516487 are associated with systemic sclerosis (SSc) in 2 European Caucasian populations and to investigate the putative gene-gene interactions between BANK1 and IRF5 as well as STAT4.	0.003724241	2009	BANK1	4	101918130	G	A
rs3821236	20383147	6775	STAT4	umls:C0036421	GAD	[Additionally, we confirm and firmly establish the role of the MHC (P = 2.31 x 10(-18)), IRF5 (P = 1.86 x 10(-13)) and STAT4 (P = 3.37 x 10(-9)) gene regions as SSc genetic risk factors.]	0.257188052	2010	STAT4	2	191038032	G	A
rs3821236	20383147	6775	STAT4	umls:C0036421	GWASCAT	Additionally, we confirm and firmly establish the role of the MHC (P = 2.31 x 10(-18)), IRF5 (P = 1.86 x 10(-13)) and STAT4 (P = 3.37 x 10(-9)) gene regions as SSc genetic risk factors.	0.257188052	2010	STAT4	2	191038032	G	A
rs3821236	22440820	919	CD247	umls:C0036421	BeFree	Five single nucleotide polymorphisms, IRF5 (rs10488631, rs12537284, rs4728142), STAT4 (rs3821236), CD247 (rs2056626) reached genome-wide significance in the SSc-GWAS and were examined in the current study.	0.24554839	2012	STAT4	2	191038032	G	A
rs3821236	21779181	6775	STAT4	umls:C0036421	GAD	[Identification of novel genetic markers associated with clinical phenotypes of systemic sclerosis through a genome-wide association strategy.]	0.257188052	2011	STAT4	2	191038032	G	A
rs3821236	21779181	6775	STAT4	umls:C0036421	GWASCAT	Identification of novel genetic markers associated with clinical phenotypes of systemic sclerosis through a genome-wide association strategy.	0.257188052	2011	STAT4	2	191038032	G	A
rs3821236	22440820	6775	STAT4	umls:C0036421	BeFree	Five single nucleotide polymorphisms, IRF5 (rs10488631, rs12537284, rs4728142), STAT4 (rs3821236), CD247 (rs2056626) reached genome-wide significance in the SSc-GWAS and were examined in the current study.	0.257188052	2012	STAT4	2	191038032	G	A
rs3827644	23740937	9474	ATG5	umls:C0036421	GWASCAT	A systemic sclerosis and systemic lupus erythematosus pan-meta-GWAS reveals new shared susceptibility loci.	0.12	2014	ATG5	6	106237320	G	C
rs386493716	24488411	7518	XRCC4	umls:C0036421	BeFree	XRCC1 (rs: 25487) and XRCC4 (rs: 28360135) allele and genotype frequencies observed in patients with SSc were not significantly different from those observed in controls; however, the XRCC1 Arg399Gln allele was associated with increased DNA damage only in healthy controls and the XRCC4 Ile401Thr allele was associated with increased DNA damage in both patients and controls.	0.000271442	2014	NA	NA	NA	NA	NA
rs386609373	22173230	1493	CTLA4	umls:C0036421	BeFree	We examined the relationship between five gene polymorphisms [cytotoxic T lymphocyte associated antigen 4 (CTLA-4) -1722T/C, CTLA-4 -318C/T, CTLA-4 +49A/G, angiotensin-converting enzyme I/D, STAT-4 rs7574865] and susceptibility to SSc.	0.024989972	2012	NA	NA	NA	NA	NA
rs386609373	22173230	1636	ACE	umls:C0036421	BeFree	We examined the relationship between five gene polymorphisms [cytotoxic T lymphocyte associated antigen 4 (CTLA-4) -1722T/C, CTLA-4 -318C/T, CTLA-4 +49A/G, angiotensin-converting enzyme I/D, STAT-4 rs7574865] and susceptibility to SSc.	0.017088363	2012	NA	NA	NA	NA	NA
rs386609373	22173230	6775	STAT4	umls:C0036421	BeFree	We examined the relationship between five gene polymorphisms [cytotoxic T lymphocyte associated antigen 4 (CTLA-4) -1722T/C, CTLA-4 -318C/T, CTLA-4 +49A/G, angiotensin-converting enzyme I/D, STAT-4 rs7574865] and susceptibility to SSc.	0.257188052	2012	NA	NA	NA	NA	NA
rs41322052	17634663	4846	NOS3	umls:C0036421	BeFree	We investigated haemorheological variables in patients with idiopathic sudden sensorineural hearing loss (ISSHL), retinal vein occlusion (RVO) and systemic sclerosis (SSc), as possible models of microvascular damage, and their relationship with eNOS gene T-786C, G894T and 4a/4b polymorphisms.	0.01654548	2007	NOS3	7	150993018	C	T
rs41322052	20406610	4846	NOS3	umls:C0036421	BeFree	Intron 4 aa genotype of eNOS gene is protective and homozygosity (CC) of T-786C promoter region is a risk factor for SSc in Turkish population.	0.01654548	2010	NOS3	7	150993018	C	T
rs443198	21779181	4855	NOTCH4	umls:C0036421	GWASCAT	Within the HLA region, HLA-DQB1, HLA-DPA1/B1, and NOTCH4 associations with SSc are likely confined to specific auto-antibodies.	0.122638474	2011	NOTCH4	6	32222629	A	G
rs443198	21779181	4855	NOTCH4	umls:C0036421	GAD	[Within the HLA region, HLA-DQB1, HLA-DPA1/B1, and NOTCH4 associations with SSc are likely confined to specific auto-antibodies.]	0.122638474	2011	NOTCH4	6	32222629	A	G
rs4728142	22440820	919	CD247	umls:C0036421	BeFree	Five single nucleotide polymorphisms, IRF5 (rs10488631, rs12537284, rs4728142), STAT4 (rs3821236), CD247 (rs2056626) reached genome-wide significance in the SSc-GWAS and were examined in the current study.	0.24554839	2012	NA	7	128933913	G	A
rs4728142	22440820	6775	STAT4	umls:C0036421	BeFree	Five single nucleotide polymorphisms, IRF5 (rs10488631, rs12537284, rs4728142), STAT4 (rs3821236), CD247 (rs2056626) reached genome-wide significance in the SSc-GWAS and were examined in the current study.	0.257188052	2012	NA	7	128933913	G	A
rs5029939	20511617	7128	TNFAIP3	umls:C0036421	BeFree	Association of the TNFAIP3 rs5029939 variant with systemic sclerosis in the European Caucasian population.	0.003452799	2010	TNFAIP3	6	137874586	C	G
rs5029939	20511617	7128	TNFAIP3	umls:C0036421	GAD	[Association of the TNFAIP3 rs5029939 variant with systemic sclerosis in the European Caucasian population.]	0.003452799	2010	TNFAIP3	6	137874586	C	G
rs6457617	20383147	3119	HLA-DQB1	umls:C0036421	GAD	[Genome-wide association study of systemic sclerosis identifies CD247 as a new susceptibility locus.]	0.15220457	2010	NA	6	32696074	C	T
rs6832151	24401602	55584	CHRNA9	umls:C0036421	BeFree	We observed nominal associations for both PPARG rs310746 (PMH = 1.90 × 10⁻⁶, OR, 1.28) and CHRNA9 rs6832151 (PMH = 4.30 × 10⁻⁶, OR, 1.17) genetic variants with SSc in the first step of our study.	0.000271442	2013	NA	4	40301616	G	A,T
rs6918698	22906474	1490	CTGF	umls:C0036421	BeFree	Association between the CTGF -945C/G polymorphism and systemic sclerosis: a meta-analysis.	0.022778711	2012	CTGF	6	131952117	G	C
rs6918698	21548990	1490	CTGF	umls:C0036421	BeFree	The -945GC polymorphism (rs6918698) in the connective tissue growth factor gene promoter (CTGF/CCN-2) has been associated with end organ damage in systemic sclerosis.	0.022778711	2011	CTGF	6	131952117	G	C
rs6932056	23124809	3394	IRF8	umls:C0036421	BeFree	We also observed associations between SSc and rs6932056 in TNFAIP3 and rs2280381 in IRF8 (P = 0.0000095 and P = 0.0030, respectively), both of which displayed associations with SSc in a European population.	0.002909916	2013	NA	6	137921300	T	C
rs704840	23740937	100506023	LOC100506023	umls:C0036421	GWASCAT	A systemic sclerosis and systemic lupus erythematosus pan-meta-GWAS reveals new shared susceptibility loci.	0.12	2014	LOC100506023	1	173257056	T	G
rs733618	22173230	6775	STAT4	umls:C0036421	BeFree	We examined the relationship between five gene polymorphisms [cytotoxic T lymphocyte associated antigen 4 (CTLA-4) -1722T/C, CTLA-4 -318C/T, CTLA-4 +49A/G, angiotensin-converting enzyme I/D, STAT-4 rs7574865] and susceptibility to SSc.	0.257188052	2012	CTLA4	2	203866221	T	C
rs733618	22173230	1493	CTLA4	umls:C0036421	BeFree	We examined the relationship between five gene polymorphisms [cytotoxic T lymphocyte associated antigen 4 (CTLA-4) -1722T/C, CTLA-4 -318C/T, CTLA-4 +49A/G, angiotensin-converting enzyme I/D, STAT-4 rs7574865] and susceptibility to SSc.	0.024989972	2012	CTLA4	2	203866221	T	C
rs733618	22173230	1636	ACE	umls:C0036421	BeFree	We examined the relationship between five gene polymorphisms [cytotoxic T lymphocyte associated antigen 4 (CTLA-4) -1722T/C, CTLA-4 -318C/T, CTLA-4 +49A/G, angiotensin-converting enzyme I/D, STAT-4 rs7574865] and susceptibility to SSc.	0.017088363	2012	CTLA4	2	203866221	T	C
rs7574865	22173230	1636	ACE	umls:C0036421	BeFree	We examined the relationship between five gene polymorphisms [cytotoxic T lymphocyte associated antigen 4 (CTLA-4) -1722T/C, CTLA-4 -318C/T, CTLA-4 +49A/G, angiotensin-converting enzyme I/D, STAT-4 rs7574865] and susceptibility to SSc.	0.017088363	2012	STAT4	2	191099907	T	G
rs7574865	21750679	6775	STAT4	umls:C0036421	GWASCAT	Genome-wide scan identifies TNIP1, PSORS1C1, and RHOB as novel risk loci for systemic sclerosis.	0.257188052	2011	STAT4	2	191099907	T	G
rs7574865	21149496	3663	IRF5	umls:C0036421	BeFree	Logistic regression analysis showed an additive effect of IRF5 rs2004640, STAT4 rs7574865 and NLRP1 rs8182352 risk alleles on SSc-related FA.	0.14309376	2011	STAT4	2	191099907	T	G
rs7574865	22173230	1493	CTLA4	umls:C0036421	BeFree	We examined the relationship between five gene polymorphisms [cytotoxic T lymphocyte associated antigen 4 (CTLA-4) -1722T/C, CTLA-4 -318C/T, CTLA-4 +49A/G, angiotensin-converting enzyme I/D, STAT-4 rs7574865] and susceptibility to SSc.	0.024989972	2012	STAT4	2	191099907	T	G
rs7574865	21149496	6775	STAT4	umls:C0036421	BeFree	Logistic regression analysis showed an additive effect of IRF5 rs2004640, STAT4 rs7574865 and NLRP1 rs8182352 risk alleles on SSc-related FA.	0.257188052	2011	STAT4	2	191099907	T	G
rs7574865	22173230	6775	STAT4	umls:C0036421	BeFree	We examined the relationship between five gene polymorphisms [cytotoxic T lymphocyte associated antigen 4 (CTLA-4) -1722T/C, CTLA-4 -318C/T, CTLA-4 +49A/G, angiotensin-converting enzyme I/D, STAT-4 rs7574865] and susceptibility to SSc.	0.257188052	2012	STAT4	2	191099907	T	G
rs7601754	23740937	6775	STAT4	umls:C0036421	GWASCAT	A systemic sclerosis and systemic lupus erythematosus pan-meta-GWAS reveals new shared susceptibility loci.	0.257188052	2014	STAT4	2	191075725	G	A
rs763361	22941566	10666	CD226	umls:C0036421	BeFree	On the other hand, associations were found between the CD226 rs763361 T allele and systemic sclerosis (SSc) and type 1 diabetes (T1D) (OR 1.126, 95% CI 1.020-1.244, p = 0.019; OR 1.353, 95% CI 1.102-1.660, p = 0.004).	0.001357209	2012	CD226	18	69864406	T	A,C
rs8182352	21149496	3663	IRF5	umls:C0036421	BeFree	Logistic regression analysis showed an additive effect of IRF5 rs2004640, STAT4 rs7574865 and NLRP1 rs8182352 risk alleles on SSc-related FA.	0.14309376	2011	NA	17	5651667	T	C
rs8182352	21149496	6775	STAT4	umls:C0036421	BeFree	Logistic regression analysis showed an additive effect of IRF5 rs2004640, STAT4 rs7574865 and NLRP1 rs8182352 risk alleles on SSc-related FA.	0.257188052	2011	NA	17	5651667	T	C
rs8192284	22742541	3569	IL6	umls:C0036421	BeFree	We aimed to investigate whether the functional genetic variants rs8192284 and rs2228044 previously associated with several autoimmune diseases, located within the IL-6 receptor (IL-6R) subunits IL6R and IL6ST genes, respectively, are involved in the susceptibility to SSc and/or its major clinical subphenotypes.	0.01198705	2012	NA	NA	NA	NA	NA
rs9275390	21779181	3119	HLA-DQB1	umls:C0036421	GAD	[Within the HLA region, HLA-DQB1, HLA-DPA1/B1, and NOTCH4 associations with SSc are likely confined to specific auto-antibodies.]	0.15220457	2011	NA	6	32701379	T	C
rs9296015	21779181	4855	NOTCH4	umls:C0036421	GAD	[Within the HLA region, HLA-DQB1, HLA-DPA1/B1, and NOTCH4 associations with SSc are likely confined to specific auto-antibodies.]	0.122638474	2011	NA	6	32251212	G	A
rs9296015	21779181	10665	C6orf10	umls:C0036421	GWASCAT	Identification of novel genetic markers associated with clinical phenotypes of systemic sclerosis through a genome-wide association strategy.	0.12	2011	NA	6	32251212	G	A
rs960709	23740937	10318	TNIP1	umls:C0036421	GWASCAT	A systemic sclerosis and systemic lupus erythematosus pan-meta-GWAS reveals new shared susceptibility loci.	0.240814326	2014	TNIP1	5	151081488	A	G
rs987870	21779181	3115	HLA-DPB1	umls:C0036421	GWASCAT	Identification of novel genetic markers associated with clinical phenotypes of systemic sclerosis through a genome-wide association strategy.	0.135830843	2011	HLA-DPA1;HLA-DPB1	6	33075103	A	G
rs987870	21779181	3113	HLA-DPA1	umls:C0036421	GWASCAT	Within the HLA region, HLA-DQB1, HLA-DPA1/B1, and NOTCH4 associations with SSc are likely confined to specific auto-antibodies.	0.122367032	2011	HLA-DPA1;HLA-DPB1	6	33075103	A	G
rs987870	21779181	3115	HLA-DPB1	umls:C0036421	GAD	[Identification of novel genetic markers associated with clinical phenotypes of systemic sclerosis through a genome-wide association strategy.]	0.135830843	2011	HLA-DPA1;HLA-DPB1	6	33075103	A	G
rs987870	21779181	3113	HLA-DPA1	umls:C0036421	GAD	[Within the HLA region, HLA-DQB1, HLA-DPA1/B1, and NOTCH4 associations with SSc are likely confined to specific auto-antibodies.]	0.122367032	2011	HLA-DPA1;HLA-DPB1	6	33075103	A	G

GWASdb Annotation(Total Genotypes:0)
(Waiting for update.)

GWASdb Snp Trait(Total Genotypes:182)
CHR	POS	SNPID	REF	ALT	ORI_SNPID	PMID	P_VALUE	P_VALUE_TEXT	OR/BETA	CI95_TEXT	GWAS_INITIAL_SAMPLE_SIZE	SUB_POPULATION	SUPER_POPULATION	GWAS_TRAIT	HPO_ID	HPO_TERM	DO_ID	DO_TERM	MESH_ID	MESH_TERM	EFO_ID	EFO_TERM	DOLITE_TERM	RISK_ALLELE	PUBLICATION_TYPE	AA	GENE_SYMBOL	TYPE	REFGENE
1	22986403	rs631090	T	C	rs631090	21750679	8.80E-05	NA	NA	NA	564 European ancestry cases; 1,776 European ancestry controls	European(2340)	ALL(2340)	EUR(2340)	ALL(2340)	Systemic sclerosis	HPOID:0000096	HPOID:0001967	HPOID:0009741	HPOID:0008664	HPOID:0001150	HPOID:0000362	HPOID:0006918	HPOID:0005450	HPOID:0005652	HPOID:0005686	HPOID:0005789	HPOID:0100923	HPOID:0100925
1	37074351	rs4653210	T	G	rs4653210	21750679	2.60E-05	NA	NA	NA	564 European ancestry cases; 1,776 European ancestry controls	European(2340)	ALL(2340)	EUR(2340)	ALL(2340)	Systemic sclerosis	HPOID:0000096	HPOID:0001967	HPOID:0009741	HPOID:0008664	HPOID:0001150	HPOID:0000362	HPOID:0006918	HPOID:0005450	HPOID:0005652	HPOID:0005686	HPOID:0005789	HPOID:0100923	HPOID:0100925
1	38806630	rs6679637	G	A	rs6679637	21750679	6.29E-05	NA	NA	NA	564 European ancestry cases; 1,776 European ancestry controls	European(2340)	ALL(2340)	EUR(2340)	ALL(2340)	Systemic sclerosis	HPOID:0000096	HPOID:0001967	HPOID:0009741	HPOID:0008664	HPOID:0001150	HPOID:0000362	HPOID:0006918	HPOID:0005450	HPOID:0005652	HPOID:0005686	HPOID:0005789	HPOID:0100923	HPOID:0100925
1	67822377	rs3790567	A	G	rs3790567	21779181	1.97E-04	NA	NA	NA	2,296 European ancestry cases; 5,172 European ancestry controls	European(7468)	ALL(7468)	EUR(7468)	ALL(7468)	Systemic sclerosis	HPOID:0000096	HPOID:0001967	HPOID:0009741	HPOID:0008664	HPOID:0001150	HPOID:0000362	HPOID:0006918	HPOID:0005450	HPOID:0005652	HPOID:0005686	HPOID:0005789	HPOID:0100923	HPOID:0100925
1	167420425	rs2056626	T	G	rs2056626	20383147	3.00E-09	NA	1.16	[1.11-1.23]	2,296 European ancestry cases; 5,171 European ancestry controls	European(7467)	ALL(7467)	EUR(7467)	ALL(7467)	Systemic sclerosis	HPOID:0000096	HPOID:0001967	HPOID:0009741	HPOID:0008664	HPOID:0001150	HPOID:0000362	HPOID:0006918	HPOID:0005450	HPOID:0005652	HPOID:0005686	HPOID:0005789	HPOID:0100923	HPOID:0100925
1	167420425	rs2056626	T	G	rs2056626	21750679	1.00E-06	NA	1.2	[1.12-1.30]	564 European ancestry cases; 1,776 European ancestry controls	European(2340)	ALL(2340)	EUR(2340)	ALL(2340)	Systemic sclerosis	HPOID:0000096	HPOID:0001967	HPOID:0009741	HPOID:0008664	HPOID:0001150	HPOID:0000362	HPOID:0006918	HPOID:0005450	HPOID:0005652	HPOID:0005686	HPOID:0005789	HPOID:0100923	HPOID:0100925
1	167420425	rs2056626	T	G	rs2056626	21779181	3.00E-06	IcSSc	1.23	[1.12-1.33]	2,296 European ancestry cases; 5,172 European ancestry controls	European(7468)	ALL(7468)	EUR(7468)	ALL(7468)	Systemic sclerosis	HPOID:0000096	HPOID:0001967	HPOID:0009741	HPOID:0008664	HPOID:0001150	HPOID:0000362	HPOID:0006918	HPOID:0005450	HPOID:0005652	HPOID:0005686	HPOID:0005789	HPOID:0100923	HPOID:0100925
1	239506077	rs10925871	G	A	rs10925871	21750679	6.38E-05	NA	NA	NA	564 European ancestry cases; 1,776 European ancestry controls	European(2340)	ALL(2340)	EUR(2340)	ALL(2340)	Systemic sclerosis	HPOID:0000096	HPOID:0001967	HPOID:0009741	HPOID:0008664	HPOID:0001150	HPOID:0000362	HPOID:0006918	HPOID:0005450	HPOID:0005652	HPOID:0005686	HPOID:0005789	HPOID:0100923	HPOID:0100925
2	10713932	rs4668690	G	A	rs4668690	21750679	8.05E-05	NA	NA	NA	564 European ancestry cases; 1,776 European ancestry controls	European(2340)	ALL(2340)	EUR(2340)	ALL(2340)	Systemic sclerosis	HPOID:0000096	HPOID:0001967	HPOID:0009741	HPOID:0008664	HPOID:0001150	HPOID:0000362	HPOID:0006918	HPOID:0005450	HPOID:0005652	HPOID:0005686	HPOID:0005789	HPOID:0100923	HPOID:0100925
2	10850929	rs7422405	G	A	rs7422405	21750679	4.55E-05	NA	NA	NA	564 European ancestry cases; 1,776 European ancestry controls	European(2340)	ALL(2340)	EUR(2340)	ALL(2340)	Systemic sclerosis	HPOID:0000096	HPOID:0001967	HPOID:0009741	HPOID:0008664	HPOID:0001150	HPOID:0000362	HPOID:0006918	HPOID:0005450	HPOID:0005652	HPOID:0005686	HPOID:0005789	HPOID:0100923	HPOID:0100925
2	20685471	rs342070	C	T	rs342070	21750679	1.04E-05	NA	NA	NA	564 European ancestry cases; 1,776 European ancestry controls	European(2340)	ALL(2340)	EUR(2340)	ALL(2340)	Systemic sclerosis	HPOID:0000096	HPOID:0001967	HPOID:0009741	HPOID:0008664	HPOID:0001150	HPOID:0000362	HPOID:0006918	HPOID:0005450	HPOID:0005652	HPOID:0005686	HPOID:0005789	HPOID:0100923	HPOID:0100925
2	20688519	rs13021401	C	T	rs13021401	21750679	3.00E-06	NA	1.21	[1.12-1.31]	564 European ancestry cases; 1,776 European ancestry controls	European(2340)	ALL(2340)	EUR(2340)	ALL(2340)	Systemic sclerosis	HPOID:0000096	HPOID:0001967	HPOID:0009741	HPOID:0008664	HPOID:0001150	HPOID:0000362	HPOID:0006918	HPOID:0005450	HPOID:0005652	HPOID:0005686	HPOID:0005789	HPOID:0100923	HPOID:0100925
2	71690860	rs11692280	G	A	rs11692280	21750679	1.08E-05	NA	NA	NA	564 European ancestry cases; 1,776 European ancestry controls	European(2340)	ALL(2340)	EUR(2340)	ALL(2340)	Systemic sclerosis	HPOID:0000096	HPOID:0001967	HPOID:0009741	HPOID:0008664	HPOID:0001150	HPOID:0000362	HPOID:0006918	HPOID:0005450	HPOID:0005652	HPOID:0005686	HPOID:0005789	HPOID:0100923	HPOID:0100925
2	191902758	rs3821236	G	A	rs3821236	20383147	3.00E-09	NA	1.3	[1.19-1.41]	2,296 European ancestry cases; 5,171 European ancestry controls	European(7467)	ALL(7467)	EUR(7467)	ALL(7467)	Systemic sclerosis	HPOID:0000096	HPOID:0001967	HPOID:0009741	HPOID:0008664	HPOID:0001150	HPOID:0000362	HPOID:0006918	HPOID:0005450	HPOID:0005652	HPOID:0005686	HPOID:0005789	HPOID:0100923	HPOID:0100925
2	191902758	rs3821236	G	A	rs3821236	21779181	9.00E-08	IcSSc	1.31	[1.19-1.48]	2,296 European ancestry cases; 5,172 European ancestry controls	European(7468)	ALL(7468)	EUR(7468)	ALL(7468)	Systemic sclerosis	HPOID:0000096	HPOID:0001967	HPOID:0009741	HPOID:0008664	HPOID:0001150	HPOID:0000362	HPOID:0006918	HPOID:0005450	HPOID:0005652	HPOID:0005686	HPOID:0005789	HPOID:0100923	HPOID:0100925
2	191964633	rs7574865	T	G	rs7574865	21750679	2.00E-13	NA	1.38	[1.27-1.50]	564 European ancestry cases; 1,776 European ancestry controls	European(2340)	ALL(2340)	EUR(2340)	ALL(2340)	Systemic sclerosis	HPOID:0000096	HPOID:0001967	HPOID:0009741	HPOID:0008664	HPOID:0001150	HPOID:0000362	HPOID:0006918	HPOID:0005450	HPOID:0005652	HPOID:0005686	HPOID:0005789	HPOID:0100923	HPOID:0100925
2	232183591	rs1868929	C	T	rs1868929	21779181	7.67E-05	NA	NA	NA	2,296 European ancestry cases; 5,172 European ancestry controls	European(7468)	ALL(7468)	EUR(7468)	ALL(7468)	Systemic sclerosis	HPOID:0000096	HPOID:0001967	HPOID:0009741	HPOID:0008664	HPOID:0001150	HPOID:0000362	HPOID:0006918	HPOID:0005450	HPOID:0005652	HPOID:0005686	HPOID:0005789	HPOID:0100923	HPOID:0100925
3	10277866	rs11706450	T	C	rs11706450	21750679	7.86E-05	NA	NA	NA	564 European ancestry cases; 1,776 European ancestry controls	European(2340)	ALL(2340)	EUR(2340)	ALL(2340)	Systemic sclerosis	HPOID:0000096	HPOID:0001967	HPOID:0009741	HPOID:0008664	HPOID:0001150	HPOID:0000362	HPOID:0006918	HPOID:0005450	HPOID:0005652	HPOID:0005686	HPOID:0005789	HPOID:0100923	HPOID:0100925
3	12259616	rs310746	C	T	rs310746	21750679	6.15E-05	NA	NA	NA	564 European ancestry cases; 1,776 European ancestry controls	European(2340)	ALL(2340)	EUR(2340)	ALL(2340)	Systemic sclerosis	HPOID:0000096	HPOID:0001967	HPOID:0009741	HPOID:0008664	HPOID:0001150	HPOID:0000362	HPOID:0006918	HPOID:0005450	HPOID:0005652	HPOID:0005686	HPOID:0005789	HPOID:0100923	HPOID:0100925
3	12493347	rs9855622	C	T	rs9855622	21750679	3.48E-06	NA	NA	NA	564 European ancestry cases; 1,776 European ancestry controls	European(2340)	ALL(2340)	EUR(2340)	ALL(2340)	Systemic sclerosis	HPOID:0000096	HPOID:0001967	HPOID:0009741	HPOID:0008664	HPOID:0001150	HPOID:0000362	HPOID:0006918	HPOID:0005450	HPOID:0005652	HPOID:0005686	HPOID:0005789	HPOID:0100923	HPOID:0100925
3	29597791	rs35883	A	G	rs35883	21750679	8.60E-05	NA	NA	NA	564 European ancestry cases; 1,776 European ancestry controls	European(2340)	ALL(2340)	EUR(2340)	ALL(2340)	Systemic sclerosis	HPOID:0000096	HPOID:0001967	HPOID:0009741	HPOID:0008664	HPOID:0001150	HPOID:0000362	HPOID:0006918	HPOID:0005450	HPOID:0005652	HPOID:0005686	HPOID:0005789	HPOID:0100923	HPOID:0100925
3	29620604	rs13323338	C	T	rs13323338	21750679	2.06E-05	NA	NA	NA	564 European ancestry cases; 1,776 European ancestry controls	European(2340)	ALL(2340)	EUR(2340)	ALL(2340)	Systemic sclerosis	HPOID:0000096	HPOID:0001967	HPOID:0009741	HPOID:0008664	HPOID:0001150	HPOID:0000362	HPOID:0006918	HPOID:0005450	HPOID:0005652	HPOID:0005686	HPOID:0005789	HPOID:0100923	HPOID:0100925
3	46644909	rs6799581	T	G	rs6799581	21750679	5.35E-05	NA	NA	NA	564 European ancestry cases; 1,776 European ancestry controls	European(2340)	ALL(2340)	EUR(2340)	ALL(2340)	Systemic sclerosis	HPOID:0000096	HPOID:0001967	HPOID:0009741	HPOID:0008664	HPOID:0001150	HPOID:0000362	HPOID:0006918	HPOID:0005450	HPOID:0005652	HPOID:0005686	HPOID:0005789	HPOID:0100923	HPOID:0100925
3	117152384	rs4128236	C	T	rs4128236	21750679	6.60E-05	NA	NA	NA	564 European ancestry cases; 1,776 European ancestry controls	European(2340)	ALL(2340)	EUR(2340)	ALL(2340)	Systemic sclerosis	HPOID:0000096	HPOID:0001967	HPOID:0009741	HPOID:0008664	HPOID:0001150	HPOID:0000362	HPOID:0006918	HPOID:0005450	HPOID:0005652	HPOID:0005686	HPOID:0005789	HPOID:0100923	HPOID:0100925
4	965779	rs11724804	G	A	rs11724804	21779181	1.99E-05	NA	NA	NA	2,296 European ancestry cases; 5,172 European ancestry controls	European(7468)	ALL(7468)	EUR(7468)	ALL(7468)	Systemic sclerosis	HPOID:0000096	HPOID:0001967	HPOID:0009741	HPOID:0008664	HPOID:0001150	HPOID:0000362	HPOID:0006918	HPOID:0005450	HPOID:0005652	HPOID:0005686	HPOID:0005789	HPOID:0100923	HPOID:0100925
4	40303633	rs6832151	G	T	rs6832151	21750679	6.11E-05	NA	NA	NA	564 European ancestry cases; 1,776 European ancestry controls	European(2340)	ALL(2340)	EUR(2340)	ALL(2340)	Systemic sclerosis	HPOID:0000096	HPOID:0001967	HPOID:0009741	HPOID:0008664	HPOID:0001150	HPOID:0000362	HPOID:0006918	HPOID:0005450	HPOID:0005652	HPOID:0005686	HPOID:0005789	HPOID:0100923	HPOID:0100925
4	95224812	rs17021463	T	G	rs17021463	21750679	9.48E-05	NA	NA	NA	564 European ancestry cases; 1,776 European ancestry controls	European(2340)	ALL(2340)	EUR(2340)	ALL(2340)	Systemic sclerosis	HPOID:0000096	HPOID:0001967	HPOID:0009741	HPOID:0008664	HPOID:0001150	HPOID:0000362	HPOID:0006918	HPOID:0005450	HPOID:0005652	HPOID:0005686	HPOID:0005789	HPOID:0100923	HPOID:0100925
4	156074074	rs13138293	T	G	rs13138293	21750679	5.47E-05	NA	NA	NA	564 European ancestry cases; 1,776 European ancestry controls	European(2340)	ALL(2340)	EUR(2340)	ALL(2340)	Systemic sclerosis	HPOID:0000096	HPOID:0001967	HPOID:0009741	HPOID:0008664	HPOID:0001150	HPOID:0000362	HPOID:0006918	HPOID:0005450	HPOID:0005652	HPOID:0005686	HPOID:0005789	HPOID:0100923	HPOID:0100925
4	156080728	rs2880417	A	G	rs2880417	21750679	9.57E-05	NA	NA	NA	564 European ancestry cases; 1,776 European ancestry controls	European(2340)	ALL(2340)	EUR(2340)	ALL(2340)	Systemic sclerosis	HPOID:0000096	HPOID:0001967	HPOID:0009741	HPOID:0008664	HPOID:0001150	HPOID:0000362	HPOID:0006918	HPOID:0005450	HPOID:0005652	HPOID:0005686	HPOID:0005789	HPOID:0100923	HPOID:0100925
5	3451906	rs32723	T	G	rs32723	21750679	6.19E-05	NA	NA	NA	564 European ancestry cases; 1,776 European ancestry controls	European(2340)	ALL(2340)	EUR(2340)	ALL(2340)	Systemic sclerosis	HPOID:0000096	HPOID:0001967	HPOID:0009741	HPOID:0008664	HPOID:0001150	HPOID:0000362	HPOID:0006918	HPOID:0005450	HPOID:0005652	HPOID:0005686	HPOID:0005789	HPOID:0100923	HPOID:0100925
5	19919301	rs1911856	T	C	rs1911856	21750679	1.04E-05	NA	NA	NA	564 European ancestry cases; 1,776 European ancestry controls	European(2340)	ALL(2340)	EUR(2340)	ALL(2340)	Systemic sclerosis	HPOID:0000096	HPOID:0001967	HPOID:0009741	HPOID:0008664	HPOID:0001150	HPOID:0000362	HPOID:0006918	HPOID:0005450	HPOID:0005652	HPOID:0005686	HPOID:0005789	HPOID:0100923	HPOID:0100925
5	19923791	rs12655266	A	G	rs12655266	21750679	3.08E-05	NA	NA	NA	564 European ancestry cases; 1,776 European ancestry controls	European(2340)	ALL(2340)	EUR(2340)	ALL(2340)	Systemic sclerosis	HPOID:0000096	HPOID:0001967	HPOID:0009741	HPOID:0008664	HPOID:0001150	HPOID:0000362	HPOID:0006918	HPOID:0005450	HPOID:0005652	HPOID:0005686	HPOID:0005789	HPOID:0100923	HPOID:0100925
5	19926525	rs2202798	T	C	rs2202798	21750679	2.60E-05	NA	NA	NA	564 European ancestry cases; 1,776 European ancestry controls	European(2340)	ALL(2340)	EUR(2340)	ALL(2340)	Systemic sclerosis	HPOID:0000096	HPOID:0001967	HPOID:0009741	HPOID:0008664	HPOID:0001150	HPOID:0000362	HPOID:0006918	HPOID:0005450	HPOID:0005652	HPOID:0005686	HPOID:0005789	HPOID:0100923	HPOID:0100925
5	62094034	rs7708428	A	G	rs7708428	21750679	4.54E-05	NA	NA	NA	564 European ancestry cases; 1,776 European ancestry controls	European(2340)	ALL(2340)	EUR(2340)	ALL(2340)	Systemic sclerosis	HPOID:0000096	HPOID:0001967	HPOID:0009741	HPOID:0008664	HPOID:0001150	HPOID:0000362	HPOID:0006918	HPOID:0005450	HPOID:0005652	HPOID:0005686	HPOID:0005789	HPOID:0100923	HPOID:0100925
5	150440097	rs2233287	G	A	rs2233287	21750679	5.00E-09	NA	1.31	[1.15-1.43]	564 European ancestry cases; 1,776 European ancestry controls	European(2340)	ALL(2340)	EUR(2340)	ALL(2340)	Systemic sclerosis	HPOID:0000096	HPOID:0001967	HPOID:0009741	HPOID:0008664	HPOID:0001150	HPOID:0000362	HPOID:0006918	HPOID:0005450	HPOID:0005652	HPOID:0005686	HPOID:0005789	HPOID:0100923	HPOID:0100925
5	150450236	rs4958881	T	C	rs4958881	21750679	1.19E-05	NA	NA	NA	564 European ancestry cases; 1,776 European ancestry controls	European(2340)	ALL(2340)	EUR(2340)	ALL(2340)	Systemic sclerosis	HPOID:0000096	HPOID:0001967	HPOID:0009741	HPOID:0008664	HPOID:0001150	HPOID:0000362	HPOID:0006918	HPOID:0005450	HPOID:0005652	HPOID:0005686	HPOID:0005789	HPOID:0100923	HPOID:0100925
5	150455732	rs3792783	A	G	rs3792783	21750679	1.14E-05	NA	NA	NA	564 European ancestry cases; 1,776 European ancestry controls	European(2340)	ALL(2340)	EUR(2340)	ALL(2340)	Systemic sclerosis	HPOID:0000096	HPOID:0001967	HPOID:0009741	HPOID:0008664	HPOID:0001150	HPOID:0000362	HPOID:0006918	HPOID:0005450	HPOID:0005652	HPOID:0005686	HPOID:0005789	HPOID:0100923	HPOID:0100925
5	168292739	rs2938769	C	T	rs2938769	21750679	2.86E-05	NA	NA	NA	564 European ancestry cases; 1,776 European ancestry controls	European(2340)	ALL(2340)	EUR(2340)	ALL(2340)	Systemic sclerosis	HPOID:0000096	HPOID:0001967	HPOID:0009741	HPOID:0008664	HPOID:0001150	HPOID:0000362	HPOID:0006918	HPOID:0005450	HPOID:0005652	HPOID:0005686	HPOID:0005789	HPOID:0100923	HPOID:0100925
6	30805921	rs3095352	C	T	rs3095352	20383147	3.12E-06	NA	NA	NA	2,296 European ancestry cases; 5,171 European ancestry controls	European(7467)	ALL(7467)	EUR(7467)	ALL(7467)	Systemic sclerosis	HPOID:0000096	HPOID:0001967	HPOID:0009741	HPOID:0008664	HPOID:0001150	HPOID:0000362	HPOID:0006918	HPOID:0005450	HPOID:0005652	HPOID:0005686	HPOID:0005789	HPOID:0100923	HPOID:0100925
6	30996132	rs564732150	C	T	rs12665700	20383147	7.25E-07	NA	NA	NA	2,296 European ancestry cases; 5,171 European ancestry controls	European(7467)	ALL(7467)	EUR(7467)	ALL(7467)	Systemic sclerosis	HPOID:0000096	HPOID:0001967	HPOID:0009741	HPOID:0008664	HPOID:0001150	HPOID:0000362	HPOID:0006918	HPOID:0005450	HPOID:0005652	HPOID:0005686	HPOID:0005789	HPOID:0100923	HPOID:0100925
6	31106268	rs3130573	A	G	rs3130573	21750679	6.00E-10	NA	1.25	[1.17-1.35]	564 European ancestry cases; 1,776 European ancestry controls	European(2340)	ALL(2340)	EUR(2340)	ALL(2340)	Systemic sclerosis	HPOID:0000096	HPOID:0001967	HPOID:0009741	HPOID:0008664	HPOID:0001150	HPOID:0000362	HPOID:0006918	HPOID:0005450	HPOID:0005652	HPOID:0005686	HPOID:0005789	HPOID:0100923	HPOID:0100925
6	31350704	rs1521	C	T	rs1521	20383147	8.96E-09	NA	NA	NA	2,296 European ancestry cases; 5,171 European ancestry controls	European(7467)	ALL(7467)	EUR(7467)	ALL(7467)	Systemic sclerosis	HPOID:0000096	HPOID:0001967	HPOID:0009741	HPOID:0008664	HPOID:0001150	HPOID:0000362	HPOID:0006918	HPOID:0005450	HPOID:0005652	HPOID:0005686	HPOID:0005789	HPOID:0100923	HPOID:0100925
6	31360389	rs2523477	T	C	rs2523477	20383147	1.94E-07	NA	NA	NA	2,296 European ancestry cases; 5,171 European ancestry controls	European(7467)	ALL(7467)	EUR(7467)	ALL(7467)	Systemic sclerosis	HPOID:0000096	HPOID:0001967	HPOID:0009741	HPOID:0008664	HPOID:0001150	HPOID:0000362	HPOID:0006918	HPOID:0005450	HPOID:0005652	HPOID:0005686	HPOID:0005789	HPOID:0100923	HPOID:0100925
6	31425985	rs2596480	C	T	rs2596480	20383147	6.55E-07	NA	NA	NA	2,296 European ancestry cases; 5,171 European ancestry controls	European(7467)	ALL(7467)	EUR(7467)	ALL(7467)	Systemic sclerosis	HPOID:0000096	HPOID:0001967	HPOID:0009741	HPOID:0008664	HPOID:0001150	HPOID:0000362	HPOID:0006918	HPOID:0005450	HPOID:0005652	HPOID:0005686	HPOID:0005789	HPOID:0100923	HPOID:0100925
6	31446796	rs2248462	G	A	rs2248462	20383147	3.27E-07	NA	NA	NA	2,296 European ancestry cases; 5,171 European ancestry controls	European(7467)	ALL(7467)	EUR(7467)	ALL(7467)	Systemic sclerosis	HPOID:0000096	HPOID:0001967	HPOID:0009741	HPOID:0008664	HPOID:0001150	HPOID:0000362	HPOID:0006918	HPOID:0005450	HPOID:0005652	HPOID:0005686	HPOID:0005789	HPOID:0100923	HPOID:0100925
6	31449994	rs2516509	T	C	rs2516509	20383147	4.19E-07	NA	NA	NA	2,296 European ancestry cases; 5,171 European ancestry controls	European(7467)	ALL(7467)	EUR(7467)	ALL(7467)	Systemic sclerosis	HPOID:0000096	HPOID:0001967	HPOID:0009741	HPOID:0008664	HPOID:0001150	HPOID:0000362	HPOID:0006918	HPOID:0005450	HPOID:0005652	HPOID:0005686	HPOID:0005789	HPOID:0100923	HPOID:0100925
6	31481299	rs2516399	A	G	rs2516399	20383147	6.27E-09	NA	NA	NA	2,296 European ancestry cases; 5,171 European ancestry controls	European(7467)	ALL(7467)	EUR(7467)	ALL(7467)	Systemic sclerosis	HPOID:0000096	HPOID:0001967	HPOID:0009741	HPOID:0008664	HPOID:0001150	HPOID:0000362	HPOID:0006918	HPOID:0005450	HPOID:0005652	HPOID:0005686	HPOID:0005789	HPOID:0100923	HPOID:0100925
6	31481526	rs2516398	G	T	rs2516398	20383147	1.64E-07	NA	NA	NA	2,296 European ancestry cases; 5,171 European ancestry controls	European(7467)	ALL(7467)	EUR(7467)	ALL(7467)	Systemic sclerosis	HPOID:0000096	HPOID:0001967	HPOID:0009741	HPOID:0008664	HPOID:0001150	HPOID:0000362	HPOID:0006918	HPOID:0005450	HPOID:0005652	HPOID:0005686	HPOID:0005789	HPOID:0100923	HPOID:0100925
6	31483415	rs2844494	C	A	rs2844494	20383147	3.22E-08	NA	NA	NA	2,296 European ancestry cases; 5,171 European ancestry controls	European(7467)	ALL(7467)	EUR(7467)	ALL(7467)	Systemic sclerosis	HPOID:0000096	HPOID:0001967	HPOID:0009741	HPOID:0008664	HPOID:0001150	HPOID:0000362	HPOID:0006918	HPOID:0005450	HPOID:0005652	HPOID:0005686	HPOID:0005789	HPOID:0100923	HPOID:0100925
6	31603591	rs2261033	A	G	rs2261033	20383147	2.49E-06	NA	NA	NA	2,296 European ancestry cases; 5,171 European ancestry controls	European(7467)	ALL(7467)	EUR(7467)	ALL(7467)	Systemic sclerosis	HPOID:0000096	HPOID:0001967	HPOID:0009741	HPOID:0008664	HPOID:0001150	HPOID:0000362	HPOID:0006918	HPOID:0005450	HPOID:0005652	HPOID:0005686	HPOID:0005789	HPOID:0100923	HPOID:0100925
6	31726688	rs707939	C	A	rs707939	20383147	6.55E-07	NA	NA	NA	2,296 European ancestry cases; 5,171 European ancestry controls	European(7467)	ALL(7467)	EUR(7467)	ALL(7467)	Systemic sclerosis	HPOID:0000096	HPOID:0001967	HPOID:0009741	HPOID:0008664	HPOID:0001150	HPOID:0000362	HPOID:0006918	HPOID:0005450	HPOID:0005652	HPOID:0005686	HPOID:0005789	HPOID:0100923	HPOID:0100925
6	31777946	rs2075800	C	T	rs2075800	20383147	1.58E-07	NA	NA	NA	2,296 European ancestry cases; 5,171 European ancestry controls	European(7467)	ALL(7467)	EUR(7467)	ALL(7467)	Systemic sclerosis	HPOID:0000096	HPOID:0001967	HPOID:0009741	HPOID:0008664	HPOID:0001150	HPOID:0000362	HPOID:0006918	HPOID:0005450	HPOID:0005652	HPOID:0005686	HPOID:0005789	HPOID:0100923	HPOID:0100925
6	31946614	rs6941112	G	A	rs6941112	20383147	2.29E-07	NA	NA	NA	2,296 European ancestry cases; 5,171 European ancestry controls	European(7467)	ALL(7467)	EUR(7467)	ALL(7467)	Systemic sclerosis	HPOID:0000096	HPOID:0001967	HPOID:0009741	HPOID:0008664	HPOID:0001150	HPOID:0000362	HPOID:0006918	HPOID:0005450	HPOID:0005652	HPOID:0005686	HPOID:0005789	HPOID:0100923	HPOID:0100925
6	32030284	rs2239689	G	A	rs2239689	20383147	4.64E-09	NA	NA	NA	2,296 European ancestry cases; 5,171 European ancestry controls	European(7467)	ALL(7467)	EUR(7467)	ALL(7467)	Systemic sclerosis	HPOID:0000096	HPOID:0001967	HPOID:0009741	HPOID:0008664	HPOID:0001150	HPOID:0000362	HPOID:0006918	HPOID:0005450	HPOID:0005652	HPOID:0005686	HPOID:0005789	HPOID:0100923	HPOID:0100925
6	32038700	rs2071295	C	T	rs2071295	20383147	2.71E-09	NA	NA	NA	2,296 European ancestry cases; 5,171 European ancestry controls	European(7467)	ALL(7467)	EUR(7467)	ALL(7467)	Systemic sclerosis	HPOID:0000096	HPOID:0001967	HPOID:0009741	HPOID:0008664	HPOID:0001150	HPOID:0000362	HPOID:0006918	HPOID:0005450	HPOID:0005652	HPOID:0005686	HPOID:0005789	HPOID:0100923	HPOID:0100925
6	32074804	rs12153855	T	C	rs12153855	20383147	5.08E-08	NA	NA	NA	2,296 European ancestry cases; 5,171 European ancestry controls	European(7467)	ALL(7467)	EUR(7467)	ALL(7467)	Systemic sclerosis	HPOID:0000096	HPOID:0001967	HPOID:0009741	HPOID:0008664	HPOID:0001150	HPOID:0000362	HPOID:0006918	HPOID:0005450	HPOID:0005652	HPOID:0005686	HPOID:0005789	HPOID:0100923	HPOID:0100925
6	32109979	rs204999	A	G	rs204999	20383147	2.30E-09	NA	NA	NA	2,296 European ancestry cases; 5,171 European ancestry controls	European(7467)	ALL(7467)	EUR(7467)	ALL(7467)	Systemic sclerosis	HPOID:0000096	HPOID:0001967	HPOID:0009741	HPOID:0008664	HPOID:0001150	HPOID:0000362	HPOID:0006918	HPOID:0005450	HPOID:0005652	HPOID:0005686	HPOID:0005789	HPOID:0100923	HPOID:0100925
6	32151222	rs1035798	G	A	rs1035798	20383147	2.66E-09	NA	NA	NA	2,296 European ancestry cases; 5,171 European ancestry controls	European(7467)	ALL(7467)	EUR(7467)	ALL(7467)	Systemic sclerosis	HPOID:0000096	HPOID:0001967	HPOID:0009741	HPOID:0008664	HPOID:0001150	HPOID:0000362	HPOID:0006918	HPOID:0005450	HPOID:0005652	HPOID:0005686	HPOID:0005789	HPOID:0100923	HPOID:0100925
6	32179896	rs2071286	C	T	rs2071286	20383147	1.67E-10	NA	NA	NA	2,296 European ancestry cases; 5,171 European ancestry controls	European(7467)	ALL(7467)	EUR(7467)	ALL(7467)	Systemic sclerosis	HPOID:0000096	HPOID:0001967	HPOID:0009741	HPOID:0008664	HPOID:0001150	HPOID:0000362	HPOID:0006918	HPOID:0005450	HPOID:0005652	HPOID:0005686	HPOID:0005789	HPOID:0100923	HPOID:0100925
6	32190406	rs443198	A	G	rs443198	20383147	6.82E-12	NA	NA	NA	2,296 European ancestry cases; 5,171 European ancestry controls	European(7467)	ALL(7467)	EUR(7467)	ALL(7467)	Systemic sclerosis	HPOID:0000096	HPOID:0001967	HPOID:0009741	HPOID:0008664	HPOID:0001150	HPOID:0000362	HPOID:0006918	HPOID:0005450	HPOID:0005652	HPOID:0005686	HPOID:0005789	HPOID:0100923	HPOID:0100925
6	32190406	rs443198	A	G	rs443198	21779181	9.00E-21	ACA positive	1.82	[1.59-2.04]	2,296 European ancestry cases; 5,172 European ancestry controls	European(7468)	ALL(7468)	EUR(7468)	ALL(7468)	Systemic sclerosis	HPOID:0000096	HPOID:0001967	HPOID:0009741	HPOID:0008664	HPOID:0001150	HPOID:0000362	HPOID:0006918	HPOID:0005450	HPOID:0005652	HPOID:0005686	HPOID:0005789	HPOID:0100923	HPOID:0100925
6	32193678	rs479536	G	A	rs479536	20383147	1.50E-08	NA	NA	NA	2,296 European ancestry cases; 5,171 European ancestry controls	European(7467)	ALL(7467)	EUR(7467)	ALL(7467)	Systemic sclerosis	HPOID:0000096	HPOID:0001967	HPOID:0009741	HPOID:0008664	HPOID:0001150	HPOID:0000362	HPOID:0006918	HPOID:0005450	HPOID:0005652	HPOID:0005686	HPOID:0005789	HPOID:0100923	HPOID:0100925
6	32218989	rs9296015	G	A	rs9296015	21779181	1.00E-08	ATA positive	1.85	[1.49-2.27]	2,296 European ancestry cases; 5,172 European ancestry controls	European(7468)	ALL(7468)	EUR(7468)	ALL(7468)	Systemic sclerosis	HPOID:0000096	HPOID:0001967	HPOID:0009741	HPOID:0008664	HPOID:0001150	HPOID:0000362	HPOID:0006918	HPOID:0005450	HPOID:0005652	HPOID:0005686	HPOID:0005789	HPOID:0100923	HPOID:0100925
6	32266490	rs28366174	T	A,C,G	rs28366174	21750679	7.81E-05	NA	NA	NA	564 European ancestry cases; 1,776 European ancestry controls	European(2340)	ALL(2340)	EUR(2340)	ALL(2340)	Systemic sclerosis	HPOID:0000096	HPOID:0001967	HPOID:0009741	HPOID:0008664	HPOID:0001150	HPOID:0000362	HPOID:0006918	HPOID:0005450	HPOID:0005652	HPOID:0005686	HPOID:0005789	HPOID:0100923	HPOID:0100925
6	32337686	rs3129941	A	G	rs3129941	20383147	1.43E-06	NA	NA	NA	2,296 European ancestry cases; 5,171 European ancestry controls	European(7467)	ALL(7467)	EUR(7467)	ALL(7467)	Systemic sclerosis	HPOID:0000096	HPOID:0001967	HPOID:0009741	HPOID:0008664	HPOID:0001150	HPOID:0000362	HPOID:0006918	HPOID:0005450	HPOID:0005652	HPOID:0005686	HPOID:0005789	HPOID:0100923	HPOID:0100925
6	32406342	rs3129871	A	C	rs3129871	20383147	4.95E-08	NA	NA	NA	2,296 European ancestry cases; 5,171 European ancestry controls	European(7467)	ALL(7467)	EUR(7467)	ALL(7467)	Systemic sclerosis	HPOID:0000096	HPOID:0001967	HPOID:0009741	HPOID:0008664	HPOID:0001150	HPOID:0000362	HPOID:0006918	HPOID:0005450	HPOID:0005652	HPOID:0005686	HPOID:0005789	HPOID:0100923	HPOID:0100925
6	32409530	rs3129882	G	A	rs3129882	21779181	2.00E-27	ATA positive	2.17	[1.88-2.50]	2,296 European ancestry cases; 5,172 European ancestry controls	European(7468)	ALL(7468)	EUR(7468)	ALL(7468)	Systemic sclerosis	HPOID:0000096	HPOID:0001967	HPOID:0009741	HPOID:0008664	HPOID:0001150	HPOID:0000362	HPOID:0006918	HPOID:0005450	HPOID:0005652	HPOID:0005686	HPOID:0005789	HPOID:0100923	HPOID:0100925
6	32590925	rs3129763	G	A	rs3129763	21779181	1.00E-11	ATA positive	1.65	[1.42-1.91]	2,296 European ancestry cases; 5,172 European ancestry controls	European(7468)	ALL(7468)	EUR(7468)	ALL(7468)	Systemic sclerosis	HPOID:0000096	HPOID:0001967	HPOID:0009741	HPOID:0008664	HPOID:0001150	HPOID:0000362	HPOID:0006918	HPOID:0005450	HPOID:0005652	HPOID:0005686	HPOID:0005789	HPOID:0100923	HPOID:0100925
6	32659878	rs9275224	A	G	rs9275224	21750679	9.18E-08	NA	NA	NA	564 European ancestry cases; 1,776 European ancestry controls	European(2340)	ALL(2340)	EUR(2340)	ALL(2340)	Systemic sclerosis	HPOID:0000096	HPOID:0001967	HPOID:0009741	HPOID:0008664	HPOID:0001150	HPOID:0000362	HPOID:0006918	HPOID:0005450	HPOID:0005652	HPOID:0005686	HPOID:0005789	HPOID:0100923	HPOID:0100925
6	32660943	rs9275245	A	G	rs9275245	21750679	1.39E-07	NA	NA	NA	564 European ancestry cases; 1,776 European ancestry controls	European(2340)	ALL(2340)	EUR(2340)	ALL(2340)	Systemic sclerosis	HPOID:0000096	HPOID:0001967	HPOID:0009741	HPOID:0008664	HPOID:0001150	HPOID:0000362	HPOID:0006918	HPOID:0005450	HPOID:0005652	HPOID:0005686	HPOID:0005789	HPOID:0100923	HPOID:0100925
6	32663564	rs5000634	A	G	rs5000634	20383147	9.13E-13	NA	NA	NA	2,296 European ancestry cases; 5,171 European ancestry controls	European(7467)	ALL(7467)	EUR(7467)	ALL(7467)	Systemic sclerosis	HPOID:0000096	HPOID:0001967	HPOID:0009741	HPOID:0008664	HPOID:0001150	HPOID:0000362	HPOID:0006918	HPOID:0005450	HPOID:0005652	HPOID:0005686	HPOID:0005789	HPOID:0100923	HPOID:0100925
6	32663851	rs6457617	C	T	rs6457617	20383147	4.00E-17	NA	1.37	[1.28-1.47]	2,296 European ancestry cases; 5,171 European ancestry controls	European(7467)	ALL(7467)	EUR(7467)	ALL(7467)	Systemic sclerosis	HPOID:0000096	HPOID:0001967	HPOID:0009741	HPOID:0008664	HPOID:0001150	HPOID:0000362	HPOID:0006918	HPOID:0005450	HPOID:0005652	HPOID:0005686	HPOID:0005789	HPOID:0100923	HPOID:0100925
6	32663851	rs6457617	C	T	rs6457617	21750679	2.00E-37	NA	1.61	[1.49-1.72]	564 European ancestry cases; 1,776 European ancestry controls	European(2340)	ALL(2340)	EUR(2340)	ALL(2340)	Systemic sclerosis	HPOID:0000096	HPOID:0001967	HPOID:0009741	HPOID:0008664	HPOID:0001150	HPOID:0000362	HPOID:0006918	HPOID:0005450	HPOID:0005652	HPOID:0005686	HPOID:0005789	HPOID:0100923	HPOID:0100925
6	32665728	rs9275312	A	G	rs9275312	20383147	3.70E-08	NA	NA	NA	2,296 European ancestry cases; 5,171 European ancestry controls	European(7467)	ALL(7467)	EUR(7467)	ALL(7467)	Systemic sclerosis	HPOID:0000096	HPOID:0001967	HPOID:0009741	HPOID:0008664	HPOID:0001150	HPOID:0000362	HPOID:0006918	HPOID:0005450	HPOID:0005652	HPOID:0005686	HPOID:0005789	HPOID:0100923	HPOID:0100925
6	32669156	rs9275390	T	C	rs9275390	20383147	1.87E-10	NA	NA	NA	2,296 European ancestry cases; 5,171 European ancestry controls	European(7467)	ALL(7467)	EUR(7467)	ALL(7467)	Systemic sclerosis	HPOID:0000096	HPOID:0001967	HPOID:0009741	HPOID:0008664	HPOID:0001150	HPOID:0000362	HPOID:0006918	HPOID:0005450	HPOID:0005652	HPOID:0005686	HPOID:0005789	HPOID:0100923	HPOID:0100925
6	32669156	rs9275390	T	C	rs9275390	21779181	1.00E-07	ATA positive	1.61	[1.35-1.92]	2,296 European ancestry cases; 5,172 European ancestry controls	European(7468)	ALL(7468)	EUR(7468)	ALL(7468)	Systemic sclerosis	HPOID:0000096	HPOID:0001967	HPOID:0009741	HPOID:0008664	HPOID:0001150	HPOID:0000362	HPOID:0006918	HPOID:0005450	HPOID:0005652	HPOID:0005686	HPOID:0005789	HPOID:0100923	HPOID:0100925
6	32669156	rs9275390	T	C	rs9275390	21779181	3.00E-54	ACA positive	2.38	[2.13-2.67]	2,296 European ancestry cases; 5,172 European ancestry controls	European(7468)	ALL(7468)	EUR(7468)	ALL(7468)	Systemic sclerosis	HPOID:0000096	HPOID:0001967	HPOID:0009741	HPOID:0008664	HPOID:0001150	HPOID:0000362	HPOID:0006918	HPOID:0005450	HPOID:0005652	HPOID:0005686	HPOID:0005789	HPOID:0100923	HPOID:0100925
6	32670000	rs2858308	G	T	rs2858308	21750679	4.76E-05	NA	NA	NA	564 European ancestry cases; 1,776 European ancestry controls	European(2340)	ALL(2340)	EUR(2340)	ALL(2340)	Systemic sclerosis	HPOID:0000096	HPOID:0001967	HPOID:0009741	HPOID:0008664	HPOID:0001150	HPOID:0000362	HPOID:0006918	HPOID:0005450	HPOID:0005652	HPOID:0005686	HPOID:0005789	HPOID:0100923	HPOID:0100925
6	32670956	rs2856705	C	T	rs2856705	20383147	3.71E-14	NA	NA	NA	2,296 European ancestry cases; 5,171 European ancestry controls	European(7467)	ALL(7467)	EUR(7467)	ALL(7467)	Systemic sclerosis	HPOID:0000096	HPOID:0001967	HPOID:0009741	HPOID:0008664	HPOID:0001150	HPOID:0000362	HPOID:0006918	HPOID:0005450	HPOID:0005652	HPOID:0005686	HPOID:0005789	HPOID:0100923	HPOID:0100925
6	32670956	rs2856705	C	T	rs2856705	21750679	4.76E-05	NA	NA	NA	564 European ancestry cases; 1,776 European ancestry controls	European(2340)	ALL(2340)	EUR(2340)	ALL(2340)	Systemic sclerosis	HPOID:0000096	HPOID:0001967	HPOID:0009741	HPOID:0008664	HPOID:0001150	HPOID:0000362	HPOID:0006918	HPOID:0005450	HPOID:0005652	HPOID:0005686	HPOID:0005789	HPOID:0100923	HPOID:0100925
6	32671103	rs13192471	T	C	rs13192471	21750679	1.81E-05	NA	NA	NA	564 European ancestry cases; 1,776 European ancestry controls	European(2340)	ALL(2340)	EUR(2340)	ALL(2340)	Systemic sclerosis	HPOID:0000096	HPOID:0001967	HPOID:0009741	HPOID:0008664	HPOID:0001150	HPOID:0000362	HPOID:0006918	HPOID:0005450	HPOID:0005652	HPOID:0005686	HPOID:0005789	HPOID:0100923	HPOID:0100925
6	32685685	rs3104398	G	A	rs3104398	20383147	2.81E-07	NA	NA	NA	2,296 European ancestry cases; 5,171 European ancestry controls	European(7467)	ALL(7467)	EUR(7467)	ALL(7467)	Systemic sclerosis	HPOID:0000096	HPOID:0001967	HPOID:0009741	HPOID:0008664	HPOID:0001150	HPOID:0000362	HPOID:0006918	HPOID:0005450	HPOID:0005652	HPOID:0005686	HPOID:0005789	HPOID:0100923	HPOID:0100925
6	32724189	rs7774954	C	A	rs7774954	20383147	3.06E-07	NA	NA	NA	2,296 European ancestry cases; 5,171 European ancestry controls	European(7467)	ALL(7467)	EUR(7467)	ALL(7467)	Systemic sclerosis	HPOID:0000096	HPOID:0001967	HPOID:0009741	HPOID:0008664	HPOID:0001150	HPOID:0000362	HPOID:0006918	HPOID:0005450	HPOID:0005652	HPOID:0005686	HPOID:0005789	HPOID:0100923	HPOID:0100925
6	33042880	rs987870	A	G	rs987870	21779181	2.00E-20	ATA positive	2.09	[1.78-2.45]	2,296 European ancestry cases; 5,172 European ancestry controls	European(7468)	ALL(7468)	EUR(7468)	ALL(7468)	Systemic sclerosis	HPOID:0000096	HPOID:0001967	HPOID:0009741	HPOID:0008664	HPOID:0001150	HPOID:0000362	HPOID:0006918	HPOID:0005450	HPOID:0005652	HPOID:0005686	HPOID:0005789	HPOID:0100923	HPOID:0100925
6	33055538	rs9277554	C	T	rs9277554	20383147	4.64E-08	NA	NA	NA	2,296 European ancestry cases; 5,171 European ancestry controls	European(7467)	ALL(7467)	EUR(7467)	ALL(7467)	Systemic sclerosis	HPOID:0000096	HPOID:0001967	HPOID:0009741	HPOID:0008664	HPOID:0001150	HPOID:0000362	HPOID:0006918	HPOID:0005450	HPOID:0005652	HPOID:0005686	HPOID:0005789	HPOID:0100923	HPOID:0100925
6	33055899	rs3128965	G	A	rs3128965	19950302	1.07E-07	Systemic sclerosis (Anti-centromere antibody positive)	NA	NA	133 Korean cases; 557 Korean controls	Korean(690)	ALL(690)	ASN(690)	ALL(690)	Systemic sclerosis	HPOID:0000096	HPOID:0001967	HPOID:0009741	HPOID:0008664	HPOID:0001150	HPOID:0000362	HPOID:0006918	HPOID:0005450	HPOID:0005652	HPOID:0005686	HPOID:0005789	HPOID:0100923	HPOID:0100925
6	33055899	rs3128965	G	A	rs3128965	19950302	1.09E-04	Systemic sclerosis (Diffuse/anti-topoisomerase I antibody)	NA	NA	133 Korean cases; 557 Korean controls	Korean(690)	ALL(690)	ASN(690)	ALL(690)	Systemic sclerosis	HPOID:0000096	HPOID:0001967	HPOID:0009741	HPOID:0008664	HPOID:0001150	HPOID:0000362	HPOID:0006918	HPOID:0005450	HPOID:0005652	HPOID:0005686	HPOID:0005789	HPOID:0100923	HPOID:0100925
6	33055899	rs3128965	G	A	rs3128965	19950302	1.29E-05	Systemic sclerosis (Limited)	NA	NA	133 Korean cases; 557 Korean controls	Korean(690)	ALL(690)	ASN(690)	ALL(690)	Systemic sclerosis	HPOID:0000096	HPOID:0001967	HPOID:0009741	HPOID:0008664	HPOID:0001150	HPOID:0000362	HPOID:0006918	HPOID:0005450	HPOID:0005652	HPOID:0005686	HPOID:0005789	HPOID:0100923	HPOID:0100925
6	33055899	rs3128965	G	A	rs3128965	19950302	1.71E-05	Systemic sclerosis (Limited/anti-centromere antibody)	NA	NA	133 Korean cases; 557 Korean controls	Korean(690)	ALL(690)	ASN(690)	ALL(690)	Systemic sclerosis	HPOID:0000096	HPOID:0001967	HPOID:0009741	HPOID:0008664	HPOID:0001150	HPOID:0000362	HPOID:0006918	HPOID:0005450	HPOID:0005652	HPOID:0005686	HPOID:0005789	HPOID:0100923	HPOID:0100925
6	33055899	rs3128965	G	A	rs3128965	19950302	4.37E-06	Systemic sclerosis (Anti-centromere antibody negative)	NA	NA	133 Korean cases; 557 Korean controls	Korean(690)	ALL(690)	ASN(690)	ALL(690)	Systemic sclerosis	HPOID:0000096	HPOID:0001967	HPOID:0009741	HPOID:0008664	HPOID:0001150	HPOID:0000362	HPOID:0006918	HPOID:0005450	HPOID:0005652	HPOID:0005686	HPOID:0005789	HPOID:0100923	HPOID:0100925
6	33055899	rs3128965	G	A	rs3128965	19950302	4.47E-05	Systemic sclerosis	NA	NA	133 Korean cases; 557 Korean controls	Korean(690)	ALL(690)	ASN(690)	ALL(690)	Systemic sclerosis	HPOID:0000096	HPOID:0001967	HPOID:0009741	HPOID:0008664	HPOID:0001150	HPOID:0000362	HPOID:0006918	HPOID:0005450	HPOID:0005652	HPOID:0005686	HPOID:0005789	HPOID:0100923	HPOID:0100925
6	33055899	rs3128965	G	A	rs3128965	19950302	6.28E-09	Systemic sclerosis (Anti-topoisomerase-I antibody positive)	NA	NA	133 Korean cases; 557 Korean controls	Korean(690)	ALL(690)	ASN(690)	ALL(690)	Systemic sclerosis	HPOID:0000096	HPOID:0001967	HPOID:0009741	HPOID:0008664	HPOID:0001150	HPOID:0000362	HPOID:0006918	HPOID:0005450	HPOID:0005652	HPOID:0005686	HPOID:0005789	HPOID:0100923	HPOID:0100925
6	33060428	rs7763822	C	T	rs7763822	19950302	1.77E-12	Systemic sclerosis (Diffuse/anti-topoisomerase I antibody)	NA	NA	133 Korean cases; 557 Korean controls	Korean(690)	ALL(690)	ASN(690)	ALL(690)	Systemic sclerosis	HPOID:0000096	HPOID:0001967	HPOID:0009741	HPOID:0008664	HPOID:0001150	HPOID:0000362	HPOID:0006918	HPOID:0005450	HPOID:0005652	HPOID:0005686	HPOID:0005789	HPOID:0100923	HPOID:0100925
6	33060428	rs7763822	C	T	rs7763822	19950302	5.28E-10	Systemic sclerosis (Diffuse)	NA	NA	133 Korean cases; 557 Korean controls	Korean(690)	ALL(690)	ASN(690)	ALL(690)	Systemic sclerosis	HPOID:0000096	HPOID:0001967	HPOID:0009741	HPOID:0008664	HPOID:0001150	HPOID:0000362	HPOID:0006918	HPOID:0005450	HPOID:0005652	HPOID:0005686	HPOID:0005789	HPOID:0100923	HPOID:0100925
6	33060428	rs7763822	C	T	rs7763822	19950302	5.60E-04	Systemic sclerosis (Anti-centromere antibody positive)	NA	NA	133 Korean cases; 557 Korean controls	Korean(690)	ALL(690)	ASN(690)	ALL(690)	Systemic sclerosis	HPOID:0000096	HPOID:0001967	HPOID:0009741	HPOID:0008664	HPOID:0001150	HPOID:0000362	HPOID:0006918	HPOID:0005450	HPOID:0005652	HPOID:0005686	HPOID:0005789	HPOID:0100923	HPOID:0100925
6	33060428	rs7763822	C	T	rs7763822	19950302	7.64E-08	Systemic sclerosis	NA	NA	133 Korean cases; 557 Korean controls	Korean(690)	ALL(690)	ASN(690)	ALL(690)	Systemic sclerosis	HPOID:0000096	HPOID:0001967	HPOID:0009741	HPOID:0008664	HPOID:0001150	HPOID:0000362	HPOID:0006918	HPOID:0005450	HPOID:0005652	HPOID:0005686	HPOID:0005789	HPOID:0100923	HPOID:0100925
6	33060428	rs7763822	C	T	rs7763822	19950302	8.24E-09	Systemic sclerosis (Anti-centromere antibody negative)	NA	NA	133 Korean cases; 557 Korean controls	Korean(690)	ALL(690)	ASN(690)	ALL(690)	Systemic sclerosis	HPOID:0000096	HPOID:0001967	HPOID:0009741	HPOID:0008664	HPOID:0001150	HPOID:0000362	HPOID:0006918	HPOID:0005450	HPOID:0005652	HPOID:0005686	HPOID:0005789	HPOID:0100923	HPOID:0100925
6	33060428	rs7763822	C	T	rs7763822	19950302	8.61E-19	Systemic sclerosis (Anti-topoisomerase-I antibody positive)	NA	NA	133 Korean cases; 557 Korean controls	Korean(690)	ALL(690)	ASN(690)	ALL(690)	Systemic sclerosis	HPOID:0000096	HPOID:0001967	HPOID:0009741	HPOID:0008664	HPOID:0001150	HPOID:0000362	HPOID:0006918	HPOID:0005450	HPOID:0005652	HPOID:0005686	HPOID:0005789	HPOID:0100923	HPOID:0100925
6	33060840	rs7764491	C	G	rs7764491	19950302	1.77E-12	Systemic sclerosis (Diffuse/anti-topoisomerase I antibody)	NA	NA	133 Korean cases; 557 Korean controls	Korean(690)	ALL(690)	ASN(690)	ALL(690)	Systemic sclerosis	HPOID:0000096	HPOID:0001967	HPOID:0009741	HPOID:0008664	HPOID:0001150	HPOID:0000362	HPOID:0006918	HPOID:0005450	HPOID:0005652	HPOID:0005686	HPOID:0005789	HPOID:0100923	HPOID:0100925
6	33060840	rs7764491	C	G	rs7764491	19950302	2.86E-18	Systemic sclerosis (Anti-topoisomerase-I antibody positive)	NA	NA	133 Korean cases; 557 Korean controls	Korean(690)	ALL(690)	ASN(690)	ALL(690)	Systemic sclerosis	HPOID:0000096	HPOID:0001967	HPOID:0009741	HPOID:0008664	HPOID:0001150	HPOID:0000362	HPOID:0006918	HPOID:0005450	HPOID:0005652	HPOID:0005686	HPOID:0005789	HPOID:0100923	HPOID:0100925
6	33060840	rs7764491	C	G	rs7764491	19950302	5.28E-10	Systemic sclerosis (Diffuse)	NA	NA	133 Korean cases; 557 Korean controls	Korean(690)	ALL(690)	ASN(690)	ALL(690)	Systemic sclerosis	HPOID:0000096	HPOID:0001967	HPOID:0009741	HPOID:0008664	HPOID:0001150	HPOID:0000362	HPOID:0006918	HPOID:0005450	HPOID:0005652	HPOID:0005686	HPOID:0005789	HPOID:0100923	HPOID:0100925
6	33060840	rs7764491	C	G	rs7764491	19950302	7.64E-08	Systemic sclerosis	NA	NA	133 Korean cases; 557 Korean controls	Korean(690)	ALL(690)	ASN(690)	ALL(690)	Systemic sclerosis	HPOID:0000096	HPOID:0001967	HPOID:0009741	HPOID:0008664	HPOID:0001150	HPOID:0000362	HPOID:0006918	HPOID:0005450	HPOID:0005652	HPOID:0005686	HPOID:0005789	HPOID:0100923	HPOID:0100925
6	33060840	rs7764491	C	G	rs7764491	19950302	8.24E-09	Systemic sclerosis (Anti-centromere antibody negative)	NA	NA	133 Korean cases; 557 Korean controls	Korean(690)	ALL(690)	ASN(690)	ALL(690)	Systemic sclerosis	HPOID:0000096	HPOID:0001967	HPOID:0009741	HPOID:0008664	HPOID:0001150	HPOID:0000362	HPOID:0006918	HPOID:0005450	HPOID:0005652	HPOID:0005686	HPOID:0005789	HPOID:0100923	HPOID:0100925
6	33075635	rs3117230	A	G	rs3117230	19950302	1.04E-05	Systemic sclerosis (Limited)	NA	NA	133 Korean cases; 557 Korean controls	Korean(690)	ALL(690)	ASN(690)	ALL(690)	Systemic sclerosis	HPOID:0000096	HPOID:0001967	HPOID:0009741	HPOID:0008664	HPOID:0001150	HPOID:0000362	HPOID:0006918	HPOID:0005450	HPOID:0005652	HPOID:0005686	HPOID:0005789	HPOID:0100923	HPOID:0100925
6	33075635	rs3117230	A	G	rs3117230	19950302	3.37E-06	Systemic sclerosis (Anti-centromere antibody negative)	NA	NA	133 Korean cases; 557 Korean controls	Korean(690)	ALL(690)	ASN(690)	ALL(690)	Systemic sclerosis	HPOID:0000096	HPOID:0001967	HPOID:0009741	HPOID:0008664	HPOID:0001150	HPOID:0000362	HPOID:0006918	HPOID:0005450	HPOID:0005652	HPOID:0005686	HPOID:0005789	HPOID:0100923	HPOID:0100925
6	33075635	rs3117230	A	G	rs3117230	19950302	3.52E-05	Systemic sclerosis	NA	NA	133 Korean cases; 557 Korean controls	Korean(690)	ALL(690)	ASN(690)	ALL(690)	Systemic sclerosis	HPOID:0000096	HPOID:0001967	HPOID:0009741	HPOID:0008664	HPOID:0001150	HPOID:0000362	HPOID:0006918	HPOID:0005450	HPOID:0005652	HPOID:0005686	HPOID:0005789	HPOID:0100923	HPOID:0100925
6	33075635	rs3117230	A	G	rs3117230	19950302	4.51E-09	Systemic sclerosis (Anti-topoisomerase-I antibody positive)	NA	NA	133 Korean cases; 557 Korean controls	Korean(690)	ALL(690)	ASN(690)	ALL(690)	Systemic sclerosis	HPOID:0000096	HPOID:0001967	HPOID:0009741	HPOID:0008664	HPOID:0001150	HPOID:0000362	HPOID:0006918	HPOID:0005450	HPOID:0005652	HPOID:0005686	HPOID:0005789	HPOID:0100923	HPOID:0100925
6	33075635	rs3117230	A	G	rs3117230	19950302	4.77E-04	Systemic sclerosis (Anti-centromere antibody positive)	NA	NA	133 Korean cases; 557 Korean controls	Korean(690)	ALL(690)	ASN(690)	ALL(690)	Systemic sclerosis	HPOID:0000096	HPOID:0001967	HPOID:0009741	HPOID:0008664	HPOID:0001150	HPOID:0000362	HPOID:0006918	HPOID:0005450	HPOID:0005652	HPOID:0005686	HPOID:0005789	HPOID:0100923	HPOID:0100925
6	33075635	rs3117230	A	G	rs3117230	19950302	6.90E-04	Systemic sclerosis (Limited/anti-centromere antibody)	NA	NA	133 Korean cases; 557 Korean controls	Korean(690)	ALL(690)	ASN(690)	ALL(690)	Systemic sclerosis	HPOID:0000096	HPOID:0001967	HPOID:0009741	HPOID:0008664	HPOID:0001150	HPOID:0000362	HPOID:0006918	HPOID:0005450	HPOID:0005652	HPOID:0005686	HPOID:0005789	HPOID:0100923	HPOID:0100925
6	33075635	rs3117230	A	G	rs3117230	19950302	9.24E-05	Systemic sclerosis (Diffuse/anti-topoisomerase I antibody)	NA	NA	133 Korean cases; 557 Korean controls	Korean(690)	ALL(690)	ASN(690)	ALL(690)	Systemic sclerosis	HPOID:0000096	HPOID:0001967	HPOID:0009741	HPOID:0008664	HPOID:0001150	HPOID:0000362	HPOID:0006918	HPOID:0005450	HPOID:0005652	HPOID:0005686	HPOID:0005789	HPOID:0100923	HPOID:0100925
6	33075666	rs3128930	C	T	rs3128930	19950302	1.15E-11	Systemic sclerosis (Diffuse)	NA	NA	133 Korean cases; 557 Korean controls	Korean(690)	ALL(690)	ASN(690)	ALL(690)	Systemic sclerosis	HPOID:0000096	HPOID:0001967	HPOID:0009741	HPOID:0008664	HPOID:0001150	HPOID:0000362	HPOID:0006918	HPOID:0005450	HPOID:0005652	HPOID:0005686	HPOID:0005789	HPOID:0100923	HPOID:0100925
6	33075666	rs3128930	C	T	rs3128930	19950302	1.67E-07	Systemic sclerosis (Limited)	NA	NA	133 Korean cases; 557 Korean controls	Korean(690)	ALL(690)	ASN(690)	ALL(690)	Systemic sclerosis	HPOID:0000096	HPOID:0001967	HPOID:0009741	HPOID:0008664	HPOID:0001150	HPOID:0000362	HPOID:0006918	HPOID:0005450	HPOID:0005652	HPOID:0005686	HPOID:0005789	HPOID:0100923	HPOID:0100925
6	33075666	rs3128930	C	T	rs3128930	19950302	3.33E-16	Systemic sclerosis (Diffuse/anti-topoisomerase I antibody)	NA	NA	133 Korean cases; 557 Korean controls	Korean(690)	ALL(690)	ASN(690)	ALL(690)	Systemic sclerosis	HPOID:0000096	HPOID:0001967	HPOID:0009741	HPOID:0008664	HPOID:0001150	HPOID:0000362	HPOID:0006918	HPOID:0005450	HPOID:0005652	HPOID:0005686	HPOID:0005789	HPOID:0100923	HPOID:0100925
6	33075666	rs3128930	C	T	rs3128930	19950302	4.38E-15	Systemic sclerosis (Anti-centromere antibody negative)	NA	NA	133 Korean cases; 557 Korean controls	Korean(690)	ALL(690)	ASN(690)	ALL(690)	Systemic sclerosis	HPOID:0000096	HPOID:0001967	HPOID:0009741	HPOID:0008664	HPOID:0001150	HPOID:0000362	HPOID:0006918	HPOID:0005450	HPOID:0005652	HPOID:0005686	HPOID:0005789	HPOID:0100923	HPOID:0100925
6	33075666	rs3128930	C	T	rs3128930	19950302	8.16E-13	Systemic sclerosis	NA	NA	133 Korean cases; 557 Korean controls	Korean(690)	ALL(690)	ASN(690)	ALL(690)	Systemic sclerosis	HPOID:0000096	HPOID:0001967	HPOID:0009741	HPOID:0008664	HPOID:0001150	HPOID:0000362	HPOID:0006918	HPOID:0005450	HPOID:0005652	HPOID:0005686	HPOID:0005789	HPOID:0100923	HPOID:0100925
6	33075666	rs3128930	C	T	rs3128930	19950302	8.26E-22	Systemic sclerosis (Anti-topoisomerase-I antibody positive)	NA	NA	133 Korean cases; 557 Korean controls	Korean(690)	ALL(690)	ASN(690)	ALL(690)	Systemic sclerosis	HPOID:0000096	HPOID:0001967	HPOID:0009741	HPOID:0008664	HPOID:0001150	HPOID:0000362	HPOID:0006918	HPOID:0005450	HPOID:0005652	HPOID:0005686	HPOID:0005789	HPOID:0100923	HPOID:0100925
6	33098276	rs6901221	A	C	rs6901221	20383147	1.19E-07	NA	NA	NA	2,296 European ancestry cases; 5,171 European ancestry controls	European(7467)	ALL(7467)	EUR(7467)	ALL(7467)	Systemic sclerosis	HPOID:0000096	HPOID:0001967	HPOID:0009741	HPOID:0008664	HPOID:0001150	HPOID:0000362	HPOID:0006918	HPOID:0005450	HPOID:0005652	HPOID:0005686	HPOID:0005789	HPOID:0100923	HPOID:0100925
6	101337611	rs9498419	A	G	rs9498419	21750679	7.76E-06	NA	NA	NA	564 European ancestry cases; 1,776 European ancestry controls	European(2340)	ALL(2340)	EUR(2340)	ALL(2340)	Systemic sclerosis	HPOID:0000096	HPOID:0001967	HPOID:0009741	HPOID:0008664	HPOID:0001150	HPOID:0000362	HPOID:0006918	HPOID:0005450	HPOID:0005652	HPOID:0005686	HPOID:0005789	HPOID:0100923	HPOID:0100925
6	101338978	rs6919745	T	C	rs6919745	21750679	8.21E-06	NA	NA	NA	564 European ancestry cases; 1,776 European ancestry controls	European(2340)	ALL(2340)	EUR(2340)	ALL(2340)	Systemic sclerosis	HPOID:0000096	HPOID:0001967	HPOID:0009741	HPOID:0008664	HPOID:0001150	HPOID:0000362	HPOID:0006918	HPOID:0005450	HPOID:0005652	HPOID:0005686	HPOID:0005789	HPOID:0100923	HPOID:0100925
6	101339400	rs7771570	C	T	rs7771570	21750679	1.82E-05	NA	NA	NA	564 European ancestry cases; 1,776 European ancestry controls	European(2340)	ALL(2340)	EUR(2340)	ALL(2340)	Systemic sclerosis	HPOID:0000096	HPOID:0001967	HPOID:0009741	HPOID:0008664	HPOID:0001150	HPOID:0000362	HPOID:0006918	HPOID:0005450	HPOID:0005652	HPOID:0005686	HPOID:0005789	HPOID:0100923	HPOID:0100925
7	25911033	rs10272701	C	T	rs10272701	21750679	9.22E-05	NA	NA	NA	564 European ancestry cases; 1,776 European ancestry controls	European(2340)	ALL(2340)	EUR(2340)	ALL(2340)	Systemic sclerosis	HPOID:0000096	HPOID:0001967	HPOID:0009741	HPOID:0008664	HPOID:0001150	HPOID:0000362	HPOID:0006918	HPOID:0005450	HPOID:0005652	HPOID:0005686	HPOID:0005789	HPOID:0100923	HPOID:0100925
7	50664922	rs12540874	A	G	rs12540874	21779181	1.00E-06	IcSSc	1.15	[1.09-1.22]	2,296 European ancestry cases; 5,172 European ancestry controls	European(7468)	ALL(7468)	EUR(7468)	ALL(7468)	Systemic sclerosis	HPOID:0000096	HPOID:0001967	HPOID:0009741	HPOID:0008664	HPOID:0001150	HPOID:0000362	HPOID:0006918	HPOID:0005450	HPOID:0005652	HPOID:0005686	HPOID:0005789	HPOID:0100923	HPOID:0100925
7	70904561	rs4585627	T	C	rs4585627	21750679	3.42E-05	NA	NA	NA	564 European ancestry cases; 1,776 European ancestry controls	European(2340)	ALL(2340)	EUR(2340)	ALL(2340)	Systemic sclerosis	HPOID:0000096	HPOID:0001967	HPOID:0009741	HPOID:0008664	HPOID:0001150	HPOID:0000362	HPOID:0006918	HPOID:0005450	HPOID:0005652	HPOID:0005686	HPOID:0005789	HPOID:0100923	HPOID:0100925
7	82005470	rs1544461	G	A	rs1544461	21750679	3.64E-05	NA	NA	NA	564 European ancestry cases; 1,776 European ancestry controls	European(2340)	ALL(2340)	EUR(2340)	ALL(2340)	Systemic sclerosis	HPOID:0000096	HPOID:0001967	HPOID:0009741	HPOID:0008664	HPOID:0001150	HPOID:0000362	HPOID:0006918	HPOID:0005450	HPOID:0005652	HPOID:0005686	HPOID:0005789	HPOID:0100923	HPOID:0100925
7	84028918	rs1228870	G	T	rs1228870	21750679	7.62E-05	NA	NA	NA	564 European ancestry cases; 1,776 European ancestry controls	European(2340)	ALL(2340)	EUR(2340)	ALL(2340)	Systemic sclerosis	HPOID:0000096	HPOID:0001967	HPOID:0009741	HPOID:0008664	HPOID:0001150	HPOID:0000362	HPOID:0006918	HPOID:0005450	HPOID:0005652	HPOID:0005686	HPOID:0005789	HPOID:0100923	HPOID:0100925
7	84086502	rs1228966	G	A	rs1228966	21750679	8.77E-05	NA	NA	NA	564 European ancestry cases; 1,776 European ancestry controls	European(2340)	ALL(2340)	EUR(2340)	ALL(2340)	Systemic sclerosis	HPOID:0000096	HPOID:0001967	HPOID:0009741	HPOID:0008664	HPOID:0001150	HPOID:0000362	HPOID:0006918	HPOID:0005450	HPOID:0005652	HPOID:0005686	HPOID:0005789	HPOID:0100923	HPOID:0100925
7	84137622	rs757747	C	T	rs757747	21750679	5.57E-05	NA	NA	NA	564 European ancestry cases; 1,776 European ancestry controls	European(2340)	ALL(2340)	EUR(2340)	ALL(2340)	Systemic sclerosis	HPOID:0000096	HPOID:0001967	HPOID:0009741	HPOID:0008664	HPOID:0001150	HPOID:0000362	HPOID:0006918	HPOID:0005450	HPOID:0005652	HPOID:0005686	HPOID:0005789	HPOID:0100923	HPOID:0100925
7	84139004	rs1029541	C	T	rs1029541	21750679	2.37E-05	NA	NA	NA	564 European ancestry cases; 1,776 European ancestry controls	European(2340)	ALL(2340)	EUR(2340)	ALL(2340)	Systemic sclerosis	HPOID:0000096	HPOID:0001967	HPOID:0009741	HPOID:0008664	HPOID:0001150	HPOID:0000362	HPOID:0006918	HPOID:0005450	HPOID:0005652	HPOID:0005686	HPOID:0005789	HPOID:0100923	HPOID:0100925
7	84328077	rs4329228	A	C	rs4329228	21750679	1.08E-05	NA	NA	NA	564 European ancestry cases; 1,776 European ancestry controls	European(2340)	ALL(2340)	EUR(2340)	ALL(2340)	Systemic sclerosis	HPOID:0000096	HPOID:0001967	HPOID:0009741	HPOID:0008664	HPOID:0001150	HPOID:0000362	HPOID:0006918	HPOID:0005450	HPOID:0005652	HPOID:0005686	HPOID:0005789	HPOID:0100923	HPOID:0100925
7	116218675	rs2402091	A	G	rs2402091	21750679	5.34E-05	NA	NA	NA	564 European ancestry cases; 1,776 European ancestry controls	European(2340)	ALL(2340)	EUR(2340)	ALL(2340)	Systemic sclerosis	HPOID:0000096	HPOID:0001967	HPOID:0009741	HPOID:0008664	HPOID:0001150	HPOID:0000362	HPOID:0006918	HPOID:0005450	HPOID:0005652	HPOID:0005686	HPOID:0005789	HPOID:0100923	HPOID:0100925
7	122527198	rs2501439	A	G	rs2501439	21750679	9.29E-05	NA	NA	NA	564 European ancestry cases; 1,776 European ancestry controls	European(2340)	ALL(2340)	EUR(2340)	ALL(2340)	Systemic sclerosis	HPOID:0000096	HPOID:0001967	HPOID:0009741	HPOID:0008664	HPOID:0001150	HPOID:0000362	HPOID:0006918	HPOID:0005450	HPOID:0005652	HPOID:0005686	HPOID:0005789	HPOID:0100923	HPOID:0100925
7	128594183	rs10488631	T	C	rs10488631	20383147	2.00E-13	NA	1.5	[1.35-1.67]	2,296 European ancestry cases; 5,171 European ancestry controls	European(7467)	ALL(7467)	EUR(7467)	ALL(7467)	Systemic sclerosis	HPOID:0000096	HPOID:0001967	HPOID:0009741	HPOID:0008664	HPOID:0001150	HPOID:0000362	HPOID:0006918	HPOID:0005450	HPOID:0005652	HPOID:0005686	HPOID:0005789	HPOID:0100923	HPOID:0100925
7	128594183	rs10488631	T	C	rs10488631	21750679	4.00E-07	NA	1.35	[1.20-1.51]	564 European ancestry cases; 1,776 European ancestry controls	European(2340)	ALL(2340)	EUR(2340)	ALL(2340)	Systemic sclerosis	HPOID:0000096	HPOID:0001967	HPOID:0009741	HPOID:0008664	HPOID:0001150	HPOID:0000362	HPOID:0006918	HPOID:0005450	HPOID:0005652	HPOID:0005686	HPOID:0005789	HPOID:0100923	HPOID:0100925
7	128594183	rs10488631	T	C	rs10488631	21779181	1.00E-09	dcSSc	1.61	[1.38-1.88]	2,296 European ancestry cases; 5,172 European ancestry controls	European(7468)	ALL(7468)	EUR(7468)	ALL(7468)	Systemic sclerosis	HPOID:0000096	HPOID:0001967	HPOID:0009741	HPOID:0008664	HPOID:0001150	HPOID:0000362	HPOID:0006918	HPOID:0005450	HPOID:0005652	HPOID:0005686	HPOID:0005789	HPOID:0100923	HPOID:0100925
7	128594183	rs10488631	T	C	rs10488631	21779181	2.00E-07	ACA positive	1.52	[1.30-1.79]	2,296 European ancestry cases; 5,172 European ancestry controls	European(7468)	ALL(7468)	EUR(7468)	ALL(7468)	Systemic sclerosis	HPOID:0000096	HPOID:0001967	HPOID:0009741	HPOID:0008664	HPOID:0001150	HPOID:0000362	HPOID:0006918	HPOID:0005450	HPOID:0005652	HPOID:0005686	HPOID:0005789	HPOID:0100923	HPOID:0100925
7	128594183	rs10488631	T	C	rs10488631	21779181	2.00E-10	IcSSc	1.5	[1.32-1.69]	2,296 European ancestry cases; 5,172 European ancestry controls	European(7468)	ALL(7468)	EUR(7468)	ALL(7468)	Systemic sclerosis	HPOID:0000096	HPOID:0001967	HPOID:0009741	HPOID:0008664	HPOID:0001150	HPOID:0000362	HPOID:0006918	HPOID:0005450	HPOID:0005652	HPOID:0005686	HPOID:0005789	HPOID:0100923	HPOID:0100925
7	128594183	rs10488631	T	C	rs10488631	21779181	8.00E-07	ATA positive	1.63	[1.34-1.98]	2,296 European ancestry cases; 5,172 European ancestry controls	European(7468)	ALL(7468)	EUR(7468)	ALL(7468)	Systemic sclerosis	HPOID:0000096	HPOID:0001967	HPOID:0009741	HPOID:0008664	HPOID:0001150	HPOID:0000362	HPOID:0006918	HPOID:0005450	HPOID:0005652	HPOID:0005686	HPOID:0005789	HPOID:0100923	HPOID:0100925
8	42657098	rs6474421	G	A	rs6474421	21750679	2.80E-05	NA	NA	NA	564 European ancestry cases; 1,776 European ancestry controls	European(2340)	ALL(2340)	EUR(2340)	ALL(2340)	Systemic sclerosis	HPOID:0000096	HPOID:0001967	HPOID:0009741	HPOID:0008664	HPOID:0001150	HPOID:0000362	HPOID:0006918	HPOID:0005450	HPOID:0005652	HPOID:0005686	HPOID:0005789	HPOID:0100923	HPOID:0100925
8	124514400	rs3739284	C	T	rs3739284	21750679	9.31E-05	NA	NA	NA	564 European ancestry cases; 1,776 European ancestry controls	European(2340)	ALL(2340)	EUR(2340)	ALL(2340)	Systemic sclerosis	HPOID:0000096	HPOID:0001967	HPOID:0009741	HPOID:0008664	HPOID:0001150	HPOID:0000362	HPOID:0006918	HPOID:0005450	HPOID:0005652	HPOID:0005686	HPOID:0005789	HPOID:0100923	HPOID:0100925
8	131161571	rs6470805	A	G	rs6470805	21750679	8.60E-05	NA	NA	NA	564 European ancestry cases; 1,776 European ancestry controls	European(2340)	ALL(2340)	EUR(2340)	ALL(2340)	Systemic sclerosis	HPOID:0000096	HPOID:0001967	HPOID:0009741	HPOID:0008664	HPOID:0001150	HPOID:0000362	HPOID:0006918	HPOID:0005450	HPOID:0005652	HPOID:0005686	HPOID:0005789	HPOID:0100923	HPOID:0100925
8	131281826	rs7839523	G	T	rs7839523	21750679	4.86E-05	NA	NA	NA	564 European ancestry cases; 1,776 European ancestry controls	European(2340)	ALL(2340)	EUR(2340)	ALL(2340)	Systemic sclerosis	HPOID:0000096	HPOID:0001967	HPOID:0009741	HPOID:0008664	HPOID:0001150	HPOID:0000362	HPOID:0006918	HPOID:0005450	HPOID:0005652	HPOID:0005686	HPOID:0005789	HPOID:0100923	HPOID:0100925
8	131319822	rs7817803	A	C	rs7817803	21750679	4.73E-05	NA	NA	NA	564 European ancestry cases; 1,776 European ancestry controls	European(2340)	ALL(2340)	EUR(2340)	ALL(2340)	Systemic sclerosis	HPOID:0000096	HPOID:0001967	HPOID:0009741	HPOID:0008664	HPOID:0001150	HPOID:0000362	HPOID:0006918	HPOID:0005450	HPOID:0005652	HPOID:0005686	HPOID:0005789	HPOID:0100923	HPOID:0100925
8	131329837	rs3057	C	T	rs3057	21750679	2.09E-05	NA	NA	NA	564 European ancestry cases; 1,776 European ancestry controls	European(2340)	ALL(2340)	EUR(2340)	ALL(2340)	Systemic sclerosis	HPOID:0000096	HPOID:0001967	HPOID:0009741	HPOID:0008664	HPOID:0001150	HPOID:0000362	HPOID:0006918	HPOID:0005450	HPOID:0005652	HPOID:0005686	HPOID:0005789	HPOID:0100923	HPOID:0100925
9	11709025	rs443042	A	G	rs443042	21750679	6.35E-05	NA	NA	NA	564 European ancestry cases; 1,776 European ancestry controls	European(2340)	ALL(2340)	EUR(2340)	ALL(2340)	Systemic sclerosis	HPOID:0000096	HPOID:0001967	HPOID:0009741	HPOID:0008664	HPOID:0001150	HPOID:0000362	HPOID:0006918	HPOID:0005450	HPOID:0005652	HPOID:0005686	HPOID:0005789	HPOID:0100923	HPOID:0100925
9	11710328	rs10756265	G	A	rs10756265	21750679	4.80E-05	NA	NA	NA	564 European ancestry cases; 1,776 European ancestry controls	European(2340)	ALL(2340)	EUR(2340)	ALL(2340)	Systemic sclerosis	HPOID:0000096	HPOID:0001967	HPOID:0009741	HPOID:0008664	HPOID:0001150	HPOID:0000362	HPOID:0006918	HPOID:0005450	HPOID:0005652	HPOID:0005686	HPOID:0005789	HPOID:0100923	HPOID:0100925
9	95845152	rs9696357	C	T	rs9696357	21750679	9.08E-05	NA	NA	NA	564 European ancestry cases; 1,776 European ancestry controls	European(2340)	ALL(2340)	EUR(2340)	ALL(2340)	Systemic sclerosis	HPOID:0000096	HPOID:0001967	HPOID:0009741	HPOID:0008664	HPOID:0001150	HPOID:0000362	HPOID:0006918	HPOID:0005450	HPOID:0005652	HPOID:0005686	HPOID:0005789	HPOID:0100923	HPOID:0100925
9	100482503	rs2668797	G	A	rs2668797	21750679	2.90E-05	NA	NA	NA	564 European ancestry cases; 1,776 European ancestry controls	European(2340)	ALL(2340)	EUR(2340)	ALL(2340)	Systemic sclerosis	HPOID:0000096	HPOID:0001967	HPOID:0009741	HPOID:0008664	HPOID:0001150	HPOID:0000362	HPOID:0006918	HPOID:0005450	HPOID:0005652	HPOID:0005686	HPOID:0005789	HPOID:0100923	HPOID:0100925
9	100496160	rs2805815	G	A	rs2805815	21750679	6.08E-05	NA	NA	NA	564 European ancestry cases; 1,776 European ancestry controls	European(2340)	ALL(2340)	EUR(2340)	ALL(2340)	Systemic sclerosis	HPOID:0000096	HPOID:0001967	HPOID:0009741	HPOID:0008664	HPOID:0001150	HPOID:0000362	HPOID:0006918	HPOID:0005450	HPOID:0005652	HPOID:0005686	HPOID:0005789	HPOID:0100923	HPOID:0100925
9	100499206	rs2805790	G	A	rs2805790	21750679	5.20E-05	NA	NA	NA	564 European ancestry cases; 1,776 European ancestry controls	European(2340)	ALL(2340)	EUR(2340)	ALL(2340)	Systemic sclerosis	HPOID:0000096	HPOID:0001967	HPOID:0009741	HPOID:0008664	HPOID:0001150	HPOID:0000362	HPOID:0006918	HPOID:0005450	HPOID:0005652	HPOID:0005686	HPOID:0005789	HPOID:0100923	HPOID:0100925
9	100505830	rs2808699	C	A	rs2808699	21750679	4.41E-05	NA	NA	NA	564 European ancestry cases; 1,776 European ancestry controls	European(2340)	ALL(2340)	EUR(2340)	ALL(2340)	Systemic sclerosis	HPOID:0000096	HPOID:0001967	HPOID:0009741	HPOID:0008664	HPOID:0001150	HPOID:0000362	HPOID:0006918	HPOID:0005450	HPOID:0005652	HPOID:0005686	HPOID:0005789	HPOID:0100923	HPOID:0100925
9	138552234	rs541131	G	A	rs541131	21750679	1.63E-05	NA	NA	NA	564 European ancestry cases; 1,776 European ancestry controls	European(2340)	ALL(2340)	EUR(2340)	ALL(2340)	Systemic sclerosis	HPOID:0000096	HPOID:0001967	HPOID:0009741	HPOID:0008664	HPOID:0001150	HPOID:0000362	HPOID:0006918	HPOID:0005450	HPOID:0005652	HPOID:0005686	HPOID:0005789	HPOID:0100923	HPOID:0100925
10	44448020	rs1254860	C	T	rs1254860	21750679	9.69E-05	NA	NA	NA	564 European ancestry cases; 1,776 European ancestry controls	European(2340)	ALL(2340)	EUR(2340)	ALL(2340)	Systemic sclerosis	HPOID:0000096	HPOID:0001967	HPOID:0009741	HPOID:0008664	HPOID:0001150	HPOID:0000362	HPOID:0006918	HPOID:0005450	HPOID:0005652	HPOID:0005686	HPOID:0005789	HPOID:0100923	HPOID:0100925
11	46180693	rs7128538	G	A	rs7128538	21750679	2.55E-05	NA	NA	NA	564 European ancestry cases; 1,776 European ancestry controls	European(2340)	ALL(2340)	EUR(2340)	ALL(2340)	Systemic sclerosis	HPOID:0000096	HPOID:0001967	HPOID:0009741	HPOID:0008664	HPOID:0001150	HPOID:0000362	HPOID:0006918	HPOID:0005450	HPOID:0005652	HPOID:0005686	HPOID:0005789	HPOID:0100923	HPOID:0100925
11	132774841	rs11223273	C	T	rs11223273	21750679	9.91E-05	NA	NA	NA	564 European ancestry cases; 1,776 European ancestry controls	European(2340)	ALL(2340)	EUR(2340)	ALL(2340)	Systemic sclerosis	HPOID:0000096	HPOID:0001967	HPOID:0009741	HPOID:0008664	HPOID:0001150	HPOID:0000362	HPOID:0006918	HPOID:0005450	HPOID:0005652	HPOID:0005686	HPOID:0005789	HPOID:0100923	HPOID:0100925
11	132779393	rs2725466	A	G	rs2725466	21750679	6.19E-06	NA	NA	NA	564 European ancestry cases; 1,776 European ancestry controls	European(2340)	ALL(2340)	EUR(2340)	ALL(2340)	Systemic sclerosis	HPOID:0000096	HPOID:0001967	HPOID:0009741	HPOID:0008664	HPOID:0001150	HPOID:0000362	HPOID:0006918	HPOID:0005450	HPOID:0005652	HPOID:0005686	HPOID:0005789	HPOID:0100923	HPOID:0100925
11	132781823	rs2725437	T	C	rs2725437	21750679	2.52E-05	NA	NA	NA	564 European ancestry cases; 1,776 European ancestry controls	European(2340)	ALL(2340)	EUR(2340)	ALL(2340)	Systemic sclerosis	HPOID:0000096	HPOID:0001967	HPOID:0009741	HPOID:0008664	HPOID:0001150	HPOID:0000362	HPOID:0006918	HPOID:0005450	HPOID:0005652	HPOID:0005686	HPOID:0005789	HPOID:0100923	HPOID:0100925
11	132795569	rs10894623	G	T	rs10894623	21750679	7.75E-05	NA	NA	NA	564 European ancestry cases; 1,776 European ancestry controls	European(2340)	ALL(2340)	EUR(2340)	ALL(2340)	Systemic sclerosis	HPOID:0000096	HPOID:0001967	HPOID:0009741	HPOID:0008664	HPOID:0001150	HPOID:0000362	HPOID:0006918	HPOID:0005450	HPOID:0005652	HPOID:0005686	HPOID:0005789	HPOID:0100923	HPOID:0100925
12	23946146	rs11047102	C	T	rs11047102	21779181	1.00E-07	ACA positive	1.36	[1.21-1.52]	2,296 European ancestry cases; 5,172 European ancestry controls	European(7468)	ALL(7468)	EUR(7468)	ALL(7468)	Systemic sclerosis	HPOID:0000096	HPOID:0001967	HPOID:0009741	HPOID:0008664	HPOID:0001150	HPOID:0000362	HPOID:0006918	HPOID:0005450	HPOID:0005652	HPOID:0005686	HPOID:0005789	HPOID:0100923	HPOID:0100925
12	23946146	rs11047102	C	T	rs11047102	21779181	5.00E-06	IcSSc	1.24	[1.13-1.35]	2,296 European ancestry cases; 5,172 European ancestry controls	European(7468)	ALL(7468)	EUR(7468)	ALL(7468)	Systemic sclerosis	HPOID:0000096	HPOID:0001967	HPOID:0009741	HPOID:0008664	HPOID:0001150	HPOID:0000362	HPOID:0006918	HPOID:0005450	HPOID:0005652	HPOID:0005686	HPOID:0005789	HPOID:0100923	HPOID:0100925
12	56518408	rs11171747	T	G	rs11171747	21779181	6.00E-08	dcSSc	1.23	[1.14-1.33]	2,296 European ancestry cases; 5,172 European ancestry controls	European(7468)	ALL(7468)	EUR(7468)	ALL(7468)	Systemic sclerosis	HPOID:0000096	HPOID:0001967	HPOID:0009741	HPOID:0008664	HPOID:0001150	HPOID:0000362	HPOID:0006918	HPOID:0005450	HPOID:0005652	HPOID:0005686	HPOID:0005789	HPOID:0100923	HPOID:0100925
12	132200162	rs10794423	C	T	rs10794423	21750679	6.32E-05	NA	NA	NA	564 European ancestry cases; 1,776 European ancestry controls	European(2340)	ALL(2340)	EUR(2340)	ALL(2340)	Systemic sclerosis	HPOID:0000096	HPOID:0001967	HPOID:0009741	HPOID:0008664	HPOID:0001150	HPOID:0000362	HPOID:0006918	HPOID:0005450	HPOID:0005652	HPOID:0005686	HPOID:0005789	HPOID:0100923	HPOID:0100925
13	34710780	rs7335534	A	G	rs7335534	21750679	9.70E-05	NA	NA	NA	564 European ancestry cases; 1,776 European ancestry controls	European(2340)	ALL(2340)	EUR(2340)	ALL(2340)	Systemic sclerosis	HPOID:0000096	HPOID:0001967	HPOID:0009741	HPOID:0008664	HPOID:0001150	HPOID:0000362	HPOID:0006918	HPOID:0005450	HPOID:0005652	HPOID:0005686	HPOID:0005789	HPOID:0100923	HPOID:0100925
13	34716493	rs11147544	A	G	rs11147544	21750679	8.26E-05	NA	NA	NA	564 European ancestry cases; 1,776 European ancestry controls	European(2340)	ALL(2340)	EUR(2340)	ALL(2340)	Systemic sclerosis	HPOID:0000096	HPOID:0001967	HPOID:0009741	HPOID:0008664	HPOID:0001150	HPOID:0000362	HPOID:0006918	HPOID:0005450	HPOID:0005652	HPOID:0005686	HPOID:0005789	HPOID:0100923	HPOID:0100925
14	33584125	rs1299512	G	A	rs1299512	21750679	8.34E-05	NA	NA	NA	564 European ancestry cases; 1,776 European ancestry controls	European(2340)	ALL(2340)	EUR(2340)	ALL(2340)	Systemic sclerosis	HPOID:0000096	HPOID:0001967	HPOID:0009741	HPOID:0008664	HPOID:0001150	HPOID:0000362	HPOID:0006918	HPOID:0005450	HPOID:0005652	HPOID:0005686	HPOID:0005789	HPOID:0100923	HPOID:0100925
14	83225103	rs1036570	A	G	rs1036570	21750679	4.88E-05	NA	NA	NA	564 European ancestry cases; 1,776 European ancestry controls	European(2340)	ALL(2340)	EUR(2340)	ALL(2340)	Systemic sclerosis	HPOID:0000096	HPOID:0001967	HPOID:0009741	HPOID:0008664	HPOID:0001150	HPOID:0000362	HPOID:0006918	HPOID:0005450	HPOID:0005652	HPOID:0005686	HPOID:0005789	HPOID:0100923	HPOID:0100925
15	67425033	rs12102171	C	T	rs12102171	21750679	3.99E-05	NA	NA	NA	564 European ancestry cases; 1,776 European ancestry controls	European(2340)	ALL(2340)	EUR(2340)	ALL(2340)	Systemic sclerosis	HPOID:0000096	HPOID:0001967	HPOID:0009741	HPOID:0008664	HPOID:0001150	HPOID:0000362	HPOID:0006918	HPOID:0005450	HPOID:0005652	HPOID:0005686	HPOID:0005789	HPOID:0100923	HPOID:0100925
15	67428014	rs4147358	C	A	rs4147358	21750679	1.65E-05	NA	NA	NA	564 European ancestry cases; 1,776 European ancestry controls	European(2340)	ALL(2340)	EUR(2340)	ALL(2340)	Systemic sclerosis	HPOID:0000096	HPOID:0001967	HPOID:0009741	HPOID:0008664	HPOID:0001150	HPOID:0000362	HPOID:0006918	HPOID:0005450	HPOID:0005652	HPOID:0005686	HPOID:0005789	HPOID:0100923	HPOID:0100925
16	49717571	rs1990629	G	A	rs1990629	21750679	7.56E-05	NA	NA	NA	564 European ancestry cases; 1,776 European ancestry controls	European(2340)	ALL(2340)	EUR(2340)	ALL(2340)	Systemic sclerosis	HPOID:0000096	HPOID:0001967	HPOID:0009741	HPOID:0008664	HPOID:0001150	HPOID:0000362	HPOID:0006918	HPOID:0005450	HPOID:0005652	HPOID:0005686	HPOID:0005789	HPOID:0100923	HPOID:0100925
16	49720240	rs1477020	T	C	rs1477020	21750679	2.49E-05	NA	NA	NA	564 European ancestry cases; 1,776 European ancestry controls	European(2340)	ALL(2340)	EUR(2340)	ALL(2340)	Systemic sclerosis	HPOID:0000096	HPOID:0001967	HPOID:0009741	HPOID:0008664	HPOID:0001150	HPOID:0000362	HPOID:0006918	HPOID:0005450	HPOID:0005652	HPOID:0005686	HPOID:0005789	HPOID:0100923	HPOID:0100925
16	65306262	rs1423773	G	A	rs1423773	21750679	6.57E-05	NA	NA	NA	564 European ancestry cases; 1,776 European ancestry controls	European(2340)	ALL(2340)	EUR(2340)	ALL(2340)	Systemic sclerosis	HPOID:0000096	HPOID:0001967	HPOID:0009741	HPOID:0008664	HPOID:0001150	HPOID:0000362	HPOID:0006918	HPOID:0005450	HPOID:0005652	HPOID:0005686	HPOID:0005789	HPOID:0100923	HPOID:0100925
16	85991705	rs11642873	A	C	rs11642873	21779181	2.00E-12	IcSSc	1.33	[1.23-1.45]	2,296 European ancestry cases; 5,172 European ancestry controls	European(7468)	ALL(7468)	EUR(7468)	ALL(7468)	Systemic sclerosis	HPOID:0000096	HPOID:0001967	HPOID:0009741	HPOID:0008664	HPOID:0001150	HPOID:0000362	HPOID:0006918	HPOID:0005450	HPOID:0005652	HPOID:0005686	HPOID:0005789	HPOID:0100923	HPOID:0100925
17	33026691	rs4795032	C	T	rs4795032	21750679	2.93E-05	NA	NA	NA	564 European ancestry cases; 1,776 European ancestry controls	European(2340)	ALL(2340)	EUR(2340)	ALL(2340)	Systemic sclerosis	HPOID:0000096	HPOID:0001967	HPOID:0009741	HPOID:0008664	HPOID:0001150	HPOID:0000362	HPOID:0006918	HPOID:0005450	HPOID:0005652	HPOID:0005686	HPOID:0005789	HPOID:0100923	HPOID:0100925
17	33078110	rs887081	T	G	rs887081	21750679	5.17E-05	NA	NA	NA	564 European ancestry cases; 1,776 European ancestry controls	European(2340)	ALL(2340)	EUR(2340)	ALL(2340)	Systemic sclerosis	HPOID:0000096	HPOID:0001967	HPOID:0009741	HPOID:0008664	HPOID:0001150	HPOID:0000362	HPOID:0006918	HPOID:0005450	HPOID:0005652	HPOID:0005686	HPOID:0005789	HPOID:0100923	HPOID:0100925
17	38092713	rs8079416	T	C	rs8079416	21750679	1.11E-05	NA	NA	NA	564 European ancestry cases; 1,776 European ancestry controls	European(2340)	ALL(2340)	EUR(2340)	ALL(2340)	Systemic sclerosis	HPOID:0000096	HPOID:0001967	HPOID:0009741	HPOID:0008664	HPOID:0001150	HPOID:0000362	HPOID:0006918	HPOID:0005450	HPOID:0005652	HPOID:0005686	HPOID:0005789	HPOID:0100923	HPOID:0100925
18	2002665	rs1940646	A	G	rs1940646	21750679	9.06E-05	NA	NA	NA	564 European ancestry cases; 1,776 European ancestry controls	European(2340)	ALL(2340)	EUR(2340)	ALL(2340)	Systemic sclerosis	HPOID:0000096	HPOID:0001967	HPOID:0009741	HPOID:0008664	HPOID:0001150	HPOID:0000362	HPOID:0006918	HPOID:0005450	HPOID:0005652	HPOID:0005686	HPOID:0005789	HPOID:0100923	HPOID:0100925
18	60683641	rs2877745	C	T	rs2877745	21750679	3.40E-05	NA	NA	NA	564 European ancestry cases; 1,776 European ancestry controls	European(2340)	ALL(2340)	EUR(2340)	ALL(2340)	Systemic sclerosis	HPOID:0000096	HPOID:0001967	HPOID:0009741	HPOID:0008664	HPOID:0001150	HPOID:0000362	HPOID:0006918	HPOID:0005450	HPOID:0005652	HPOID:0005686	HPOID:0005789	HPOID:0100923	HPOID:0100925
18	72186404	rs2241508	G	A	rs2241508	21750679	1.80E-05	NA	NA	NA	564 European ancestry cases; 1,776 European ancestry controls	European(2340)	ALL(2340)	EUR(2340)	ALL(2340)	Systemic sclerosis	HPOID:0000096	HPOID:0001967	HPOID:0009741	HPOID:0008664	HPOID:0001150	HPOID:0000362	HPOID:0006918	HPOID:0005450	HPOID:0005652	HPOID:0005686	HPOID:0005789	HPOID:0100923	HPOID:0100925
19	11417200	rs322151	C	T	rs322151	21750679	7.79E-05	NA	NA	NA	564 European ancestry cases; 1,776 European ancestry controls	European(2340)	ALL(2340)	EUR(2340)	ALL(2340)	Systemic sclerosis	HPOID:0000096	HPOID:0001967	HPOID:0009741	HPOID:0008664	HPOID:0001150	HPOID:0000362	HPOID:0006918	HPOID:0005450	HPOID:0005652	HPOID:0005686	HPOID:0005789	HPOID:0100923	HPOID:0100925
21	19474615	rs2248200	C	T	rs2248200	21750679	8.85E-05	NA	NA	NA	564 European ancestry cases; 1,776 European ancestry controls	European(2340)	ALL(2340)	EUR(2340)	ALL(2340)	Systemic sclerosis	HPOID:0000096	HPOID:0001967	HPOID:0009741	HPOID:0008664	HPOID:0001150	HPOID:0000362	HPOID:0006918	HPOID:0005450	HPOID:0005652	HPOID:0005686	HPOID:0005789	HPOID:0100923	HPOID:0100925
21	19474777	rs1688165	A	G	rs1688165	21750679	8.27E-05	NA	NA	NA	564 European ancestry cases; 1,776 European ancestry controls	European(2340)	ALL(2340)	EUR(2340)	ALL(2340)	Systemic sclerosis	HPOID:0000096	HPOID:0001967	HPOID:0009741	HPOID:0008664	HPOID:0001150	HPOID:0000362	HPOID:0006918	HPOID:0005450	HPOID:0005652	HPOID:0005686	HPOID:0005789	HPOID:0100923	HPOID:0100925
21	29485359	rs2831511	C	T	rs2831511	21750679	9.71E-05	NA	NA	NA	564 European ancestry cases; 1,776 European ancestry controls	European(2340)	ALL(2340)	EUR(2340)	ALL(2340)	Systemic sclerosis	HPOID:0000096	HPOID:0001967	HPOID:0009741	HPOID:0008664	HPOID:0001150	HPOID:0000362	HPOID:0006918	HPOID:0005450	HPOID:0005652	HPOID:0005686	HPOID:0005789	HPOID:0100923	HPOID:0100925
22	18877787	rs2543958	T	G	rs2543958	21750679	7.46E-05	NA	NA	NA	564 European ancestry cases; 1,776 European ancestry controls	European(2340)	ALL(2340)	EUR(2340)	ALL(2340)	Systemic sclerosis	HPOID:0000096	HPOID:0001967	HPOID:0009741	HPOID:0008664	HPOID:0001150	HPOID:0000362	HPOID:0006918	HPOID:0005450	HPOID:0005652	HPOID:0005686	HPOID:0005789	HPOID:0100923	HPOID:0100925

Mapped by lexical matching(Total Items:0)
(Waiting for update.)

Mapped by homologous gene(Total Items:0)
(Waiting for update.)

Chemical(Total Drugs:11)
CUI	ChemicalName	ChemicalID	CasRN	DiseaseName	DiseaseID	DirectEvidence	PubMedIDs
C0036421	bleomycin	D001761	11056-06-7	scleroderma, systemic	MESH:D012595	marker/mechanism	19147827
C0036421	carbidopa	D002230	38821-49-7	scleroderma, systemic	MESH:D012595	marker/mechanism	6997735
C0036421	cyclophosphamide	D003520	50-18-0	scleroderma, systemic	MESH:D012595	therapeutic	16636934
C0036421	dihydroergotamine	D004087	511-12-6	scleroderma, systemic	MESH:D012595	therapeutic	9794162
C0036421	griseofulvin	D006118	126-07-8	scleroderma, systemic	MESH:D012595	therapeutic	4579328
C0036421	rosiglitazone	C089730	-	scleroderma, systemic	MESH:D012595	therapeutic	19147827
C0036421	tacrolimus	D016559	109581-93-3	scleroderma, systemic	MESH:D012595	marker/mechanism	22836123
C0036421	cyclophosphamide	D003520	50-18-0	scleroderma, diffuse	MESH:D045743	marker/mechanism	15725240
C0036421	cyclophosphamide	D003520	50-18-0	scleroderma, diffuse	MESH:D045743	therapeutic	17888219
C0036421	gemcitabine	C056507	103882-84-4	scleroderma, diffuse	MESH:D045743	marker/mechanism	15280817
C0036421	paclitaxel	D017239	-	scleroderma, diffuse	MESH:D045743	marker/mechanism	12605319

FDA approved drug and dosage information(Total Drugs:0)
(Waiting for update.)

FDA labeling changes(Total Drugs:0)
(Waiting for update.)