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Pediatric Disease Annotations & Medicines



   syphilis
  

Disease ID 1287
Disease syphilis
Definition
A contagious venereal disease caused by the spirochete TREPONEMA PALLIDUM.
Synonym
[x]syphilis, unspecified
[x]syphilis, unspecified (disorder)
great pox
infection by treponema pallidum
lues
luetic disease
pox, great
syphilis (disorder)
syphilis [disease/finding]
syphilis nos
syphilis nos (disorder)
syphilis, nos
syphilis, stage unspecified
syphilis, unspecified
DOID
ICD10
UMLS
C0039128
MeSH
SNOMED-CT
Comorbidity
UMLS | Disease | Sentences' Count(Total Sentences:71)
C0019158  |  hepatitis  |  6
C0042164  |  uveitis  |  5
C0015230  |  rash  |  4
C0019163  |  hepatitis b  |  2
C0042769  |  virus infection  |  2
C0030343  |  panuveitis  |  2
C0027726  |  nephrotic syndrome  |  2
C0007939  |  chancre  |  2
C0008148  |  chlamydia  |  2
C0024530  |  malaria  |  2
C0003509  |  aortitis  |  2
C0019196  |  hepatitis c  |  2
C0003486  |  aortic aneurysm  |  2
C0007785  |  cerebral ischemia  |  1
C0039223  |  tabes dorsalis  |  1
C0002170  |  alopecia  |  1
C0042109  |  urticaria  |  1
C0007785  |  cerebral infarcts  |  1
C0030807  |  pemphigus  |  1
C0242231  |  coronary stenosis  |  1
C0007939  |  primary syphilis  |  1
C0023895  |  liver disease  |  1
C0019342  |  genital herpes  |  1
C0030824  |  penicillin allergy  |  1
C0018784  |  sensorineural hearing loss  |  1
C0007785  |  cerebral infarct  |  1
C0153166  |  syphilitic meningitis  |  1
C0022568  |  keratitis  |  1
C0029134  |  optic neuritis  |  1
C0022408  |  arthropathy  |  1
C0030809  |  pemphigus vulgaris  |  1
C0030305  |  pancreatitis  |  1
C0153188  |  tertiary syphilis  |  1
C0085074  |  granuloma annulare  |  1
C0003511  |  syphilitic aortitis  |  1
C0036220  |  kaposi sarcoma  |  1
C1276146  |  cutaneous lymphoma  |  1
C0021359  |  infertile  |  1
C0042167  |  posterior uveitis  |  1
C0029443  |  osteomyelitis  |  1
C0042165  |  anterior uveitis  |  1
C0015230  |  cutaneous eruption  |  1
C0027720  |  nephrosis  |  1
C0019048  |  hemoglobinuria  |  1
C0023646  |  lichen planus  |  1
C0376358  |  prostate cancer  |  1
C0039103  |  synovitis  |  1
C0019342  |  herpes genitalis  |  1
C0497327  |  dementia  |  1
C0022658  |  renal disease  |  1
C0349464  |  korsakoff's syndrome  |  1
C0162872  |  thoracic aortic aneurysm  |  1
C0024205  |  lymphadenitis  |  1
C0000809  |  recurrent miscarriage  |  1
C0022116  |  ischemia  |  1
C0033860  |  psoriasis  |  1
C0014118  |  endocarditis  |  1
C0000809  |  recurrent miscarriages  |  1
C0042384  |  vasculitis  |  1
C0027813  |  neuritis  |  1
C0265098  |  basilar artery occlusion  |  1
C0004623  |  bacterial infection  |  1
C0040558  |  toxoplasmosis  |  1
C0029089  |  ophthalmoplegia  |  1
C0004153  |  atherosclerosis  |  1
C0003892  |  neuropathic arthropathy  |  1
C0022661  |  end-stage renal disease  |  1
C0036416  |  scleritis  |  1
C0039131  |  congenital syphilis  |  1
C0079773  |  cutaneous t-cell lymphoma  |  1
C0040561  |  ocular toxoplasmosis  |  1
Curated Gene(Waiting for update.)
Inferring Gene(Waiting for update.)
Text Mined Gene
Entrez_id | Symbol | Score | Resource(Total Genes:163)
2288  |  FKBP4  |  DISEASES
10942  |  PRSS21  |  DISEASES
920  |  CD4  |  DISEASES
7216  |  TRO  |  DISEASES
9812  |  KIAA0141  |  DISEASES
350  |  APOH  |  DISEASES
7051  |  TGM1  |  DISEASES
5594  |  MAPK1  |  DISEASES
9567  |  GTPBP1  |  DISEASES
4627  |  MYH9  |  DISEASES
26258  |  BLOC1S6  |  DISEASES
2137  |  EXTL3  |  DISEASES
973  |  CD79A  |  DISEASES
2584  |  GALK1  |  DISEASES
6347  |  CCL2  |  DISEASES
3558  |  IL2  |  DISEASES
11044  |  PAPD7  |  DISEASES
3565  |  IL4  |  DISEASES
5657  |  PRTN3  |  DISEASES
58512  |  DLGAP3  |  DISEASES
8574  |  AKR7A2  |  DISEASES
5273  |  SERPINB10  |  DISEASES
8997  |  KALRN  |  DISEASES
92797  |  HELB  |  DISEASES
968  |  CD68  |  DISEASES
23647  |  ARFIP2  |  DISEASES
1401  |  CRP  |  DISEASES
80326  |  WNT10A  |  DISEASES
3569  |  IL6  |  DISEASES
7097  |  TLR2  |  DISEASES
4659  |  PPP1R12A  |  DISEASES
4069  |  LYZ  |  DISEASES
10162  |  LPCAT3  |  DISEASES
11019  |  LIAS  |  DISEASES
55813  |  UTP6  |  DISEASES
8483  |  CILP  |  DISEASES
1387  |  CREBBP  |  DISEASES
27130  |  INVS  |  DISEASES
27033  |  ZBTB32  |  DISEASES
898  |  CCNE1  |  DISEASES
11043  |  MID2  |  DISEASES
25939  |  SAMHD1  |  DISEASES
55686  |  MREG  |  DISEASES
9424  |  KCNK6  |  DISEASES
28960  |  DCPS  |  DISEASES
941  |  CD80  |  DISEASES
3371  |  TNC  |  DISEASES
2028  |  ENPEP  |  DISEASES
27074  |  LAMP3  |  DISEASES
51608  |  GET4  |  DISEASES
55749  |  CCAR1  |  DISEASES
3700  |  ITIH4  |  DISEASES
54858  |  PGPEP1  |  DISEASES
150094  |  SIK1  |  DISEASES
8915  |  BCL10  |  DISEASES
5546  |  PRCC  |  DISEASES
9869  |  SETDB1  |  DISEASES
25953  |  PNKD  |  DISEASES
1030  |  CDKN2B  |  DISEASES
55079  |  FEZF2  |  DISEASES
29789  |  OLA1  |  DISEASES
10563  |  CXCL13  |  DISEASES
29028  |  ATAD2  |  DISEASES
5147  |  PDE6D  |  DISEASES
1636  |  ACE  |  DISEASES
1234  |  CCR5  |  DISEASES
3046  |  HBE1  |  DISEASES
160622  |  GRASP  |  DISEASES
6006  |  RHCE  |  DISEASES
213  |  ALB  |  DISEASES
9607  |  CARTPT  |  DISEASES
115825  |  WDFY2  |  DISEASES
124872  |  B4GALNT2  |  DISEASES
140838  |  NANP  |  DISEASES
140738  |  TMEM37  |  DISEASES
1841  |  DTYMK  |  DISEASES
54538  |  ROBO4  |  DISEASES
3627  |  CXCL10  |  DISEASES
56246  |  MRAP  |  DISEASES
2147  |  F2  |  DISEASES
407  |  ARR3  |  DISEASES
64759  |  TNS3  |  DISEASES
354  |  KLK3  |  DISEASES
55024  |  BANK1  |  DISEASES
10938  |  EHD1  |  DISEASES
6014  |  RIT2  |  DISEASES
2274  |  FHL2  |  DISEASES
9033  |  PKD2L1  |  DISEASES
79228  |  THOC6  |  DISEASES
30845  |  EHD3  |  DISEASES
9582  |  APOBEC3B  |  DISEASES
9146  |  HGS  |  DISEASES
7490  |  WT1  |  DISEASES
5271  |  SERPINB8  |  DISEASES
2242  |  FES  |  DISEASES
222546  |  RFX6  |  DISEASES
2152  |  F3  |  DISEASES
5269  |  SERPINB6  |  DISEASES
23583  |  SMUG1  |  DISEASES
3805  |  KIR2DL4  |  DISEASES
11188  |  NISCH  |  DISEASES
3329  |  HSPD1  |  DISEASES
23136  |  EPB41L3  |  DISEASES
51513  |  ETV7  |  DISEASES
28986  |  MAGEH1  |  DISEASES
3792  |  KEL  |  DISEASES
3240  |  HP  |  DISEASES
85301  |  COL27A1  |  DISEASES
130013  |  ACMSD  |  DISEASES
5625  |  PRODH  |  DISEASES
83658  |  DYNLRB1  |  DISEASES
135250  |  RAET1E  |  DISEASES
26136  |  TES  |  DISEASES
9652  |  TTC37  |  DISEASES
8532  |  CPZ  |  DISEASES
7044  |  LEFTY2  |  DISEASES
3664  |  IRF6  |  DISEASES
7175  |  TPR  |  DISEASES
9095  |  TBX19  |  DISEASES
51175  |  TUBE1  |  DISEASES
262  |  AMD1  |  DISEASES
2316  |  FLNA  |  DISEASES
22823  |  MTF2  |  DISEASES
253152  |  EPHX4  |  DISEASES
2635  |  GBP3  |  DISEASES
8804  |  CREG1  |  DISEASES
959  |  CD40LG  |  DISEASES
6491  |  STIL  |  DISEASES
3376  |  IARS  |  DISEASES
11074  |  TRIM31  |  DISEASES
8718  |  TNFRSF25  |  DISEASES
127262  |  TPRG1L  |  DISEASES
5422  |  POLA1  |  DISEASES
9308  |  CD83  |  DISEASES
51360  |  MBTPS2  |  DISEASES
3704  |  ITPA  |  DISEASES
5272  |  SERPINB9  |  DISEASES
6736  |  SRY  |  DISEASES
9467  |  SH3BP5  |  DISEASES
3886  |  KRT35  |  DISEASES
7018  |  TF  |  DISEASES
7124  |  TNF  |  DISEASES
84256  |  FLYWCH1  |  DISEASES
10165  |  SLC25A13  |  DISEASES
7148  |  TNXB  |  DISEASES
389549  |  FEZF1  |  DISEASES
3586  |  IL10  |  DISEASES
133396  |  IL31RA  |  DISEASES
721  |  C4B  |  DISEASES
629  |  CFB  |  DISEASES
8314  |  BAP1  |  DISEASES
165631  |  PARP15  |  DISEASES
339487  |  ZBTB8OS  |  DISEASES
347273  |  MURC  |  DISEASES
51428  |  DDX41  |  DISEASES
23221  |  RHOBTB2  |  DISEASES
6917  |  TCEA1  |  DISEASES
7732  |  RNF112  |  DISEASES
6139  |  RPL17  |  DISEASES
246734  |  NPCDR1  |  DISEASES
25859  |  PART1  |  DISEASES
677807  |  SNORA22  |  DISEASES
100128252  |  ZNF667-AS1  |  DISEASES
Locus(Waiting for update.)
Disease ID 1287
Disease syphilis
Integrated Phenotype(Waiting for update.)
Text Mined Phenotype
HPO | Name | Sentences' Count(Total Phenotypes:56)
HP:0012115  |  Liver inflammation  |  6
HP:0000554  |  Uveitis  |  5
HP:0002721  |  Immunodeficiency  |  5
HP:0002617  |  Aneurysmal dilatation  |  4
HP:0000100  |  Nephrosis  |  3
HP:0012121  |  Panuveitis  |  2
HP:0000365  |  Hearing impairment  |  2
HP:0004942  |  Aortic aneurysm  |  2
HP:0000988  |  Exanthem  |  2
HP:0003470  |  Inability to move  |  2
HP:0001025  |  Hives  |  1
HP:0012393  |  Allergy  |  1
HP:0002633  |  Vasculitis  |  1
HP:0000726  |  Dementia  |  1
HP:0003249  |  Genital ulcers  |  1
HP:0000491  |  Corneal inflammation  |  1
HP:0000707  |  Neurological abnormality  |  1
HP:0000407  |  sensorineural hearing loss  |  1
HP:0002202  |  Pleural effusion  |  1
HP:0100769  |  Synovitis  |  1
HP:0100653  |  Optic neuritis  |  1
HP:0003040  |  Arthropathy  |  1
HP:0002664  |  Neoplasia  |  1
HP:0001268  |  Mental deterioration  |  1
HP:0012089  |  Arteritis  |  1
HP:0000613  |  Extreme light sensitivity  |  1
HP:0002597  |  Abnormality of blood vessels  |  1
HP:0002821  |  Charcot arthropathy  |  1
HP:0012125  |  Prostate cancer  |  1
HP:0002621  |  Atherosclerosis  |  1
HP:0012727  |  Thoracic aortic aneurysm  |  1
HP:0012122  |  Anterior uveitis  |  1
HP:0002754  |  Bone infection  |  1
HP:0001297  |  Cerebral vascular events  |  1
HP:0012860  |  Fibrotic testicle  |  1
HP:0003774  |  End-stage renal failure  |  1
HP:0002315  |  Headaches  |  1
HP:0002840  |  Lymphadenitis  |  1
HP:0030692  |  Brain tumor  |  1
HP:0001945  |  Fever  |  1
HP:0000602  |  Ophthalmoplegia  |  1
HP:0002637  |  Brain ischemia  |  1
HP:0003641  |  Hemoglobin in urine  |  1
HP:0100532  |  Scleritis  |  1
HP:0012192  |  Cutaneous T-cell lymphoma  |  1
HP:0001733  |  Pancreatic inflammation  |  1
HP:0100584  |  Endocarditis  |  1
HP:0001596  |  Hair loss  |  1
HP:0003414  |  Atlantoaxial subluxation  |  1
HP:0000360  |  Ringing in the ears  |  1
HP:0012123  |  Posterior uveitis  |  1
HP:0200042  |  Skin ulcer  |  1
HP:0100256  |  Neuritic plaques  |  1
HP:0001410  |  Decreased liver function  |  1
HP:0003765  |  Psoriasis  |  1
HP:0000572  |  Visual loss  |  1
Disease ID 1287
Disease syphilis
Manually Symptom(Waiting for update.)
Text Mined Symptom
UMLS | Name | Sentences' Count(Total Symptoms:14)
C0009450  |  infection  |  65
C0021311  |  infections  |  12
C0002940  |  aneurysm  |  4
C0027726  |  nephrotic syndrome  |  2
C0007939  |  chancre  |  2
C0037284  |  skin lesions  |  2
C0024530  |  malaria  |  2
C0018681  |  headache  |  1
C0007939  |  chancres  |  1
C0003892  |  neuropathic arthropathy  |  1
C0919615  |  meningoradiculitis  |  1
C0497327  |  dementia  |  1
C0275524  |  mixed infection  |  1
C0277787  |  stigmata  |  1
Manually Genotype(Total Text Mining Genotypes:0)
(Waiting for update.)
All Snps(Total Genotypes:0)
(Waiting for update.)
GWASdb Annotation(Total Genotypes:0)
(Waiting for update.)
GWASdb Snp Trait(Total Genotypes:0)
(Waiting for update.)
Mapped by lexical matching(Total Items:0)
(Waiting for update.)
Mapped by homologous gene(Total Items:0)
(Waiting for update.)
Chemical(Total Drugs:1)
CUI ChemicalName ChemicalID CasRN DiseaseName DiseaseID DirectEvidence PubMedIDs
C0039128doxycyclineD004318564-25-0syphilisMESH:D013587therapeutic8108759
FDA approved drug and dosage information(Total Drugs:0)
(Waiting for update.)
FDA labeling changes(Total Drugs:0)
(Waiting for update.)