PedAM

Pediatric Disease Annotations & Medicines


	synovitis

Disease ID	587
Disease	synovitis
Definition	Inflammation of the SYNOVIAL MEMBRANE.
Synonym	synovitides synovitis (disorder) synovitis [disease/finding] synovitis nos synovitis, nos
DOID	DOID:2703
UMLS	C0039103
MeSH	D013585
SNOMED-CT	SNOMEDCT_US_2016_09_01:416209007
Comorbidity	UMLS \| Disease \| Sentences' Count(Total Sentences:50) C0003873 \| rheumatoid arthritis \| 33 C0003864 \| arthritis \| 29 C0553662 \| juvenile idiopathic arthritis \| 6 C0029408 \| osteoarthritis \| 6 C0003864 \| inflammatory arthritis \| 5 C0003872 \| psoriatic arthritis \| 3 C1253936 \| joint effusion \| 3 C0006444 \| bursitis \| 3 C0003874 \| septic arthritis \| 2 C1956089 \| osteophyte \| 2 C0019069 \| haemophilia \| 2 C0023234 \| perthes disease \| 2 C0042974 \| von willebrand disease \| 1 C0002766 \| analgesia \| 1 C0029443 \| osteomyelitis \| 1 C0011644 \| scleroderma \| 1 C0018099 \| gout \| 1 C0041296 \| tuberculosis \| 1 C0038363 \| aphthous ulcer \| 1 C0031090 \| periodontal disease \| 1 C0521515 \| calcific tendinitis \| 1 C0032650 \| popliteal cyst \| 1 C0032533 \| polymyalgia rheumatica \| 1 C0038363 \| aphthous ulceration \| 1 C0022116 \| ischemia \| 1 C0021053 \| immune disease \| 1 C0023418 \| leukemia \| 1 C0024141 \| systemic lupus erythematosus \| 1 C0006309 \| brucellosis \| 1 C0206644 \| fibrous histiocytoma \| 1 C0019069 \| hemophilia \| 1 C0022408 \| osteoarthrosis \| 1 C0020538 \| hypertension \| 1 C0022408 \| arthropathy \| 1 C0679362 \| extrapulmonary tuberculosis \| 1 C0022408 \| joint diseases \| 1 C0029456 \| osteoporosis \| 1 C0007286 \| carpal tunnel syndrome \| 1 C0003864 \| joint inflammation \| 1 C0040053 \| thrombosis \| 1 C0022408 \| joint disease \| 1 C0041327 \| pulmonary tuberculosis \| 1 C0949691 \| spondyloarthropathy \| 1 C0039520 \| tenosynovitis \| 1 C0033860 \| psoriasis \| 1 C0085574 \| palindromic rheumatism \| 1 C1861303 \| blau syndrome \| 1 C0039128 \| syphilis \| 1 C0035435 \| rheumatism \| 1 C0026986 \| myelodysplastic syndrome \| 1
Curated Gene	Entrez_id \| Symbol \| Resource(Total Genes:3) POMC \| 5443 \| CTD_human HLA-B \| 3106 \| CTD_human COL2A1 \| 1280 \| CTD_human
Inferring Gene	(Waiting for update.)
Text Mined Gene	Entrez_id \| Symbol \| Score \| Resource(Total Genes:284) 54814 \| QPCTL \| DISEASES 79931 \| TNIP3 \| DISEASES 7132 \| TNFRSF1A \| DISEASES 2046 \| EPHA8 \| DISEASES 5442 \| POLRMT \| DISEASES 4616 \| GADD45B \| DISEASES 4282 \| MIF \| DISEASES 5008 \| OSM \| DISEASES 7076 \| TIMP1 \| DISEASES 54 \| ACP5 \| DISEASES 4313 \| MMP2 \| DISEASES 4210 \| MEFV \| DISEASES 8797 \| TNFRSF10A \| DISEASES 7040 \| TGFB1 \| DISEASES 973 \| CD79A \| DISEASES 1311 \| COMP \| DISEASES 5919 \| RARRES2 \| DISEASES 944 \| TNFSF8 \| DISEASES 6348 \| CCL3 \| DISEASES 4353 \| MPO \| DISEASES 6347 \| CCL2 \| DISEASES 6357 \| CCL13 \| DISEASES 952 \| CD38 \| DISEASES 3558 \| IL2 \| DISEASES 969 \| CD69 \| DISEASES 51561 \| IL23A \| DISEASES 3458 \| IFNG \| DISEASES 55907 \| CMAS \| DISEASES 3820 \| KLRB1 \| DISEASES 3565 \| IL4 \| DISEASES 5657 \| PRTN3 \| DISEASES 6402 \| SELL \| DISEASES 1509 \| CTSD \| DISEASES 4317 \| MMP8 \| DISEASES 8600 \| TNFSF11 \| DISEASES 5153 \| PDE1B \| DISEASES 56848 \| SPHK2 \| DISEASES 6662 \| SOX9 \| DISEASES 718 \| C3 \| DISEASES 3976 \| LIF \| DISEASES 968 \| CD68 \| DISEASES 6351 \| CCL4 \| DISEASES 5908 \| RAP1B \| DISEASES 11027 \| LILRA2 \| DISEASES 1890 \| TYMP \| DISEASES 26025 \| PCDHGA12 \| DISEASES 25873 \| RPL36 \| DISEASES 2161 \| F12 \| DISEASES 3958 \| LGALS3 \| DISEASES 6382 \| SDC1 \| DISEASES 1401 \| CRP \| DISEASES 1116 \| CHI3L1 \| DISEASES 11095 \| ADAMTS8 \| DISEASES 3569 \| IL6 \| DISEASES 3557 \| IL1RN \| DISEASES 26525 \| IL36RN \| DISEASES 6366 \| CCL21 \| DISEASES 7097 \| TLR2 \| DISEASES 4322 \| MMP13 \| DISEASES 3685 \| ITGAV \| DISEASES 30061 \| SLC40A1 \| DISEASES 11213 \| IRAK3 \| DISEASES 4069 \| LYZ \| DISEASES 7450 \| VWF \| DISEASES 9663 \| LPIN2 \| DISEASES 8483 \| CILP \| DISEASES 4053 \| LTBP2 \| DISEASES 56052 \| ALG1 \| DISEASES 9739 \| SETD1A \| DISEASES 7077 \| TIMP2 \| DISEASES 3552 \| IL1A \| DISEASES 3553 \| IL1B \| DISEASES 9410 \| SNRNP40 \| DISEASES 3574 \| IL7 \| DISEASES 941 \| CD80 \| DISEASES 8808 \| IL1RL2 \| DISEASES 2247 \| FGF2 \| DISEASES 3589 \| IL11 \| DISEASES 6774 \| STAT3 \| DISEASES 3383 \| ICAM1 \| DISEASES 3827 \| KNG1 \| DISEASES 8829 \| NRP1 \| DISEASES 27074 \| LAMP3 \| DISEASES 4123 \| MAN2C1 \| DISEASES 170691 \| ADAMTS17 \| DISEASES 10261 \| IGSF6 \| DISEASES 1009 \| CDH11 \| DISEASES 593 \| BCKDHA \| DISEASES 150094 \| SIK1 \| DISEASES 58985 \| IL22RA1 \| DISEASES 1513 \| CTSK \| DISEASES 6988 \| TCTA \| DISEASES 170690 \| ADAMTS16 \| DISEASES 526 \| ATP6V1B2 \| DISEASES 4851 \| NOTCH1 \| DISEASES 10205 \| MPZL2 \| DISEASES 3606 \| IL18 \| DISEASES 2321 \| FLT1 \| DISEASES 223117 \| SEMA3D \| DISEASES 7070 \| THY1 \| DISEASES 9510 \| ADAMTS1 \| DISEASES 11096 \| ADAMTS5 \| DISEASES 1436 \| CSF1R \| DISEASES 10563 \| CXCL13 \| DISEASES 3815 \| KIT \| DISEASES 1234 \| CCR5 \| DISEASES 6352 \| CCL5 \| DISEASES 7805 \| LAPTM5 \| DISEASES 7412 \| VCAM1 \| DISEASES 2215 \| FCGR3B \| DISEASES 23498 \| HAAO \| DISEASES 1293 \| COL6A3 \| DISEASES 213 \| ALB \| DISEASES 84818 \| IL17RC \| DISEASES 1230 \| CCR1 \| DISEASES 3600 \| IL15 \| DISEASES 2150 \| F2RL1 \| DISEASES 1437 \| CSF2 \| DISEASES 4982 \| TNFRSF11B \| DISEASES 81034 \| SLC25A32 \| DISEASES 2350 \| FOLR2 \| DISEASES 23588 \| KLHDC2 \| DISEASES 84659 \| RNASE7 \| DISEASES 79841 \| AGBL2 \| DISEASES 64112 \| MOAP1 \| DISEASES 4314 \| MMP3 \| DISEASES 64127 \| NOD2 \| DISEASES 353514 \| LILRA5 \| DISEASES 2990 \| GUSB \| DISEASES 3688 \| ITGB1 \| DISEASES 6869 \| TACR1 \| DISEASES 1493 \| CTLA4 \| DISEASES 171558 \| PTCRA \| DISEASES 1469 \| CST1 \| DISEASES 56246 \| MRAP \| DISEASES 4323 \| MMP14 \| DISEASES 197259 \| MLKL \| DISEASES 5340 \| PLG \| DISEASES 947 \| CD34 \| DISEASES 27165 \| GLS2 \| DISEASES 358 \| AQP1 \| DISEASES 5319 \| PLA2G1B \| DISEASES 8639 \| AOC3 \| DISEASES 1604 \| CD55 \| DISEASES 2744 \| GLS \| DISEASES 28959 \| TMEM176B \| DISEASES 23786 \| BCL2L13 \| DISEASES 3579 \| CXCR2 \| DISEASES 6863 \| TAC1 \| DISEASES 3039 \| HBA1 \| DISEASES 4312 \| MMP1 \| DISEASES 2 \| A2M \| DISEASES 9622 \| KLK4 \| DISEASES 1435 \| CSF1 \| DISEASES 23046 \| KIF21B \| DISEASES 706 \| TSPO \| DISEASES 9021 \| SOCS3 \| DISEASES 5155 \| PDGFB \| DISEASES 8701 \| DNAH11 \| DISEASES 283871 \| PGP \| DISEASES 6401 \| SELE \| DISEASES 942 \| CD86 \| DISEASES 79582 \| SPAG16 \| DISEASES 153201 \| SLC36A2 \| DISEASES 114548 \| NLRP3 \| DISEASES 7189 \| TRAF6 \| DISEASES 3091 \| HIF1A \| DISEASES 23583 \| SMUG1 \| DISEASES 5329 \| PLAUR \| DISEASES 54468 \| MIOS \| DISEASES 3329 \| HSPD1 \| DISEASES 3804 \| KIR2DL3 \| DISEASES 9536 \| PTGES \| DISEASES 3146 \| HMGB1 \| DISEASES 3716 \| JAK1 \| DISEASES 5549 \| PRELP \| DISEASES 3605 \| IL17A \| DISEASES 26232 \| FBXO2 \| DISEASES 728 \| C5AR1 \| DISEASES 80781 \| COL18A1 \| DISEASES 5265 \| SERPINA1 \| DISEASES 3683 \| ITGAL \| DISEASES 23141 \| ANKLE2 \| DISEASES 4477 \| MSMB \| DISEASES 2213 \| FCGR2B \| DISEASES 2526 \| FUT4 \| DISEASES 6364 \| CCL20 \| DISEASES 9332 \| CD163 \| DISEASES 123096 \| SLC25A29 \| DISEASES 799 \| CALCR \| DISEASES 3123 \| HLA-DRB1 \| DISEASES 2157 \| F8 \| DISEASES 5599 \| MAPK8 \| DISEASES 1066 \| CES1 \| DISEASES 4326 \| MMP17 \| DISEASES 6772 \| STAT1 \| DISEASES 5742 \| PTGS1 \| DISEASES 8838 \| WISP3 \| DISEASES 28982 \| FLVCR1 \| DISEASES 1378 \| CR1 \| DISEASES 1380 \| CR2 \| DISEASES 7432 \| VIP \| DISEASES 5788 \| PTPRC \| DISEASES 5321 \| PLA2G4A \| DISEASES 5743 \| PTGS2 \| DISEASES 6375 \| XCL1 \| DISEASES 6675 \| UAP1 \| DISEASES 2214 \| FCGR3A \| DISEASES 8038 \| ADAM12 \| DISEASES 6283 \| S100A12 \| DISEASES 6280 \| S100A9 \| DISEASES 2312 \| FLG \| DISEASES 1520 \| CTSS \| DISEASES 2209 \| FCGR1A \| DISEASES 914 \| CD2 \| DISEASES 965 \| CD58 \| DISEASES 4803 \| NGF \| DISEASES 9446 \| GSTO1 \| DISEASES 959 \| CD40LG \| DISEASES 10561 \| IFI44 \| DISEASES 10964 \| IFI44L \| DISEASES 7422 \| VEGFA \| DISEASES 4318 \| MMP9 \| DISEASES 7075 \| TIE1 \| DISEASES 5303 \| PIN4 \| DISEASES 4146 \| MATN1 \| DISEASES 7321 \| UBE2D1 \| DISEASES 7099 \| TLR4 \| DISEASES 5320 \| PLA2G2A \| DISEASES 23569 \| PADI4 \| DISEASES 51702 \| PADI3 \| DISEASES 54829 \| ASPN \| DISEASES 6850 \| SYK \| DISEASES 3055 \| HCK \| DISEASES 10673 \| TNFSF13B \| DISEASES 7133 \| TNFRSF1B \| DISEASES 1041 \| CDSN \| DISEASES 6354 \| CCL7 \| DISEASES 221044 \| UCMA \| DISEASES 79689 \| STEAP4 \| DISEASES 1645 \| AKR1C1 \| DISEASES 90865 \| IL33 \| DISEASES 140809 \| SRXN1 \| DISEASES 3681 \| ITGAD \| DISEASES 55022 \| PID1 \| DISEASES 8065 \| CUL5 \| DISEASES 51520 \| LARS \| DISEASES 9560 \| CCL4L2 \| DISEASES 6355 \| CCL8 \| DISEASES 6696 \| SPP1 \| DISEASES 2919 \| CXCL1 \| DISEASES 6387 \| CXCL12 \| DISEASES 56666 \| PANX2 \| DISEASES 3652 \| IPP \| DISEASES 594857 \| NPS \| DISEASES 9050 \| PSTPIP2 \| DISEASES 176 \| ACAN \| DISEASES 3718 \| JAK3 \| DISEASES 8399 \| PLA2G10 \| DISEASES 115677 \| NOSTRIN \| DISEASES 283463 \| MUC19 \| DISEASES 720 \| C4A \| DISEASES 960 \| CD44 \| DISEASES 7124 \| TNF \| DISEASES 10216 \| PRG4 \| DISEASES 5817 \| PVR \| DISEASES 388372 \| CCL4L1 \| DISEASES 834 \| CASP1 \| DISEASES 3586 \| IL10 \| DISEASES 27180 \| SIGLEC9 \| DISEASES 135656 \| DPCR1 \| DISEASES 6452 \| SH3BP2 \| DISEASES 51428 \| DDX41 \| DISEASES 9791 \| PTDSS1 \| DISEASES 113174 \| SAAL1 \| DISEASES 9774 \| BCLAF1 \| DISEASES 3684 \| ITGAM \| DISEASES 11331 \| PHB2 \| DISEASES 5228 \| PGF \| DISEASES 3892 \| KRT86 \| DISEASES 9051 \| PSTPIP1 \| DISEASES 567 \| B2M \| DISEASES 6223 \| RPS19 \| DISEASES 26783 \| SNORA65 \| DISEASES
Locus	(Waiting for update.)

Disease ID	587
Disease	synovitis
Integrated Phenotype	(Waiting for update.)
Text Mined Phenotype	HPO \| Name \| Sentences' Count(Total Phenotypes:34) HP:0000969 \| Dropsy \| 39 HP:0001370 \| Rheumatoid arthritis \| 33 HP:0001369 \| Arthritis \| 29 HP:0012531 \| Pain \| 17 HP:0005086 \| Knee osteoarthritis \| 10 HP:0002758 \| Osteoarthritis \| 6 HP:0005681 \| Juvenile idiopathic arthritis \| 6 HP:0100773 \| Cartilage destruction \| 3 HP:0030839 \| Knee pain \| 3 HP:0003095 \| Septic arthritis \| 2 HP:0001760 \| Foot deformities \| 2 HP:0000939 \| Osteoporosis \| 1 HP:0003731 \| Quadriceps weakness \| 1 HP:0002664 \| Neoplasia \| 1 HP:0002720 \| Decreased immunoglobulin A \| 1 HP:0002863 \| Myelodysplastic syndrome \| 1 HP:0001997 \| Gout \| 1 HP:0100246 \| Osteoma \| 1 HP:0030433 \| Osteoid osteoma \| 1 HP:0000024 \| Inflammation of the prostate \| 1 HP:0100324 \| Progressive systemic scleroderma \| 1 HP:0002754 \| Bone infection \| 1 HP:0000822 \| Hypertension \| 1 HP:0003040 \| Arthropathy \| 1 HP:0002960 \| Autoimmune condition \| 1 HP:0012219 \| Erythema nodosum \| 1 HP:0001909 \| Leukemia \| 1 HP:0100686 \| Enthesitis \| 1 HP:0003765 \| Psoriasis \| 1 HP:0002829 \| Arthralgias \| 1 HP:0002725 \| Systemic lupus erythematosus \| 1 HP:0010783 \| Erythema \| 1 HP:0001386 \| Joint swelling \| 1 HP:0007626 \| Osteomyelitis, especially of the mandible \| 1

Disease ID	587
Disease	synovitis
Manually Symptom	UMLS \| Name(Total Manually Symptoms:9) C2598155 \| pain C2029884 \| hearing loss C0426768 \| o sign C0263390 \| scleromyxoedema C0037284 \| skin lesions C0029443 \| osteomyelitis C0029441 \| osteoid osteoma C0008707 \| chronic osteomyelitis C0003864 \| arthritis
Text Mined Symptom	UMLS \| Name \| Sentences' Count(Total Symptoms:7) C0003864 \| arthritis \| 29 C0030193 \| pain \| 17 C0426768 \| o sign \| 2 C0029441 \| osteoid osteoma \| 1 C1384666 \| hearing loss \| 1 C0029443 \| osteomyelitis \| 1 C0037284 \| skin lesions \| 1

Manually Genotype(Total Text Mining Genotypes:0)
(Waiting for update.)

All Snps(Total Genotypes:0)
(Waiting for update.)

GWASdb Annotation(Total Genotypes:0)
(Waiting for update.)

GWASdb Snp Trait(Total Genotypes:0)
(Waiting for update.)

Mapped by lexical matching(Total Items:0)
(Waiting for update.)

Mapped by homologous gene(Total Items:0)
(Waiting for update.)

Chemical(Total Drugs:5)
CUI	ChemicalName	ChemicalID	CasRN	DiseaseName	DiseaseID	DirectEvidence	PubMedIDs
C0039103	chlorambucil	D002699	305-03-3	synovitis	MESH:D013585	therapeutic	3970039
C0039103	cyclophosphamide	D003520	50-18-0	synovitis	MESH:D013585	therapeutic	3970039
C0039103	methotrexate	D008727	1959/5/2	synovitis	MESH:D013585	therapeutic	3970039
C0039103	propylthiouracil	D011441	51-52-5	synovitis	MESH:D013585	marker/mechanism	6850193
C0039103	tretinoin	D014212	302-79-4	synovitis	MESH:D013585	marker/mechanism	20009973

FDA approved drug and dosage information(Total Drugs:0)
(Waiting for update.)

FDA labeling changes(Total Drugs:0)
(Waiting for update.)

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