PedAM
Pediatric Disease Annotations & Medicines
| syndrome of inappropriate antidiuretic hormone | ||||
| Disease ID | 1309 |
|---|---|
| Disease | syndrome of inappropriate antidiuretic hormone |
| Definition | A condition of HYPONATREMIA and renal salt loss attributed to overexpansion of BODY FLUIDS resulting from sustained release of ANTIDIURETIC HORMONES which stimulates renal resorption of water. It is characterized by normal KIDNEY function, high urine OSMOLALITY, low serum osmolality, and neurological dysfunction. Etiologies include ADH-producing neoplasms, injuries or diseases involving the HYPOTHALAMUS, the PITUITARY GLAND, and the LUNG. This syndrome can also be drug-induced. |
| Synonym | adh inappropriate adh inappropriate secretion adh inappropriate syndrome adh inappropriate syndromes adh syndrome, inappropriate antidiuretic hormone inappropriate secret antidiuretic hormone inappropriate secretion syndrome antidiuretic hormone inappropriate secretion syndrome siadh antidiuretic hormone, inappropriate secretion inappropriate adh inappropriate adh secretion inappropriate adh syndrome inappropriate adh syndrome [disease/finding] inappropriate antidiuretic hormone secretion syndrome inappropriate secretion of antidiuretic hormone inappropriate vasopressin secret syndrome inappropriate vasopressin secretion syndrome schwartz bartter syndrome schwartz-bartter syndrome schwarz-bartter syndrome siad - syndrome of inappropriate antidiuresis siadh siadh - syndrome of inappropriate secretion of antidiuretic hormone siadhs syndrome inappropriate adh syndrome inappropriate adh siadh secret syndrome of inappropriate adh (siadh) secretion syndrome of inappropriate adh production syndrome of inappropriate antidiuresis syndrome of inappropriate antidiuretic hormone (siadh) syndrome of inappropriate antidiuretic hormone secretion syndrome of inappropriate secretion of adh syndrome of inappropriate secretion of antidiuretic hormone syndrome of inappropriate secretion of antidiuretic hormone (disorder) syndrome of inappropriate vasopressin secretion syndrome of inappropriate vasopressin secretion (disorder) syndrome, inappropriate adh syndrome, schwartz-bartter |
| DOID | |
| ICD10 | |
| UMLS | C0021141 |
| MeSH | |
| SNOMED-CT | |
| Comorbidity | UMLS | Disease | Sentences' Count(Total Sentences:40) C0011847 | diabetes | 2 C0011848 | diabetes insipidus | 2 C0023890 | cirrhosis | 2 C0206717 | olfactory neuroblastoma | 2 C0025202 | melanoma | 1 C0012739 | disseminated intravascular coagulation | 1 C0278701 | gastric adenocarcinoma | 1 C0026764 | plasma cell myeloma | 1 C0027873 | neuromyelitis optica | 1 C1834580 | ramsay hunt syndrome | 1 C0025202 | malignant melanoma | 1 C0206754 | neuroendocrine tumor | 1 C0041296 | tuberculosis | 1 C0041327 | pulmonary tuberculosis | 1 C1140680 | ovarian cancer | 1 C0027819 | neuroblastoma | 1 C0376358 | prostate cancer | 1 C0025289 | meningitis | 1 C0001623 | adrenal insufficiency | 1 C0020676 | hypothyroidism | 1 C0018378 | guillain-barre syndrome | 1 C0023890 | liver cirrhosis | 1 C0024115 | pulmonary disease | 1 C0149925 | small cell carcinoma | 1 C0085253 | adult still's disease | 1 C1140680 | ovarian ca | 1 C0023895 | liver disease | 1 C0023493 | adult t-cell leukaemia/lymphoma | 1 C0242379 | lung cancer | 1 C0019099 | crimean-congo hemorrhagic fever | 1 C0235660 | galactorrhea | 1 C0302592 | carcinoma of the uterine cervix | 1 C0162429 | malnutrition | 1 C0278883 | metastatic melanoma | 1 C0022972 | myasthenic syndrome | 1 C1565489 | renal insufficiency | 1 C0023493 | adult t-cell leukaemia | 1 C0010481 | cushing's syndrome | 1 C0001418 | adenocarcinoma | 1 C0149925 | small cell lung cancer | 1 |
| Curated Gene | Entrez_id | Symbol | Resource(Total Genes:1) |
| Inferring Gene | (Waiting for update.) |
| Text Mined Gene | Entrez_id | Symbol | Score | Resource(Total Genes:46) 359 | AQP2 | DISEASES 5020 | OXT | DISEASES 343 | AQP8 | DISEASES 2026 | ENO2 | DISEASES 6615 | SNAI1 | DISEASES 6568 | SLC17A1 | DISEASES 1264 | CNN1 | DISEASES 3569 | IL6 | DISEASES 109 | ADCY3 | DISEASES 23476 | BRD4 | DISEASES 5775 | PTPN4 | DISEASES 1371 | CPOX | DISEASES 5443 | POMC | DISEASES 56606 | SLC2A9 | DISEASES 5972 | REN | DISEASES 10699 | CORIN | DISEASES 1392 | CRH | DISEASES 3060 | HCRT | DISEASES 213 | ALB | DISEASES 364 | AQP7 | DISEASES 360 | AQP3 | DISEASES 717 | C2 | DISEASES 7846 | TUBA1A | DISEASES 5368 | PNOC | DISEASES 5729 | PTGDR | DISEASES 29984 | RHOD | DISEASES 358 | AQP1 | DISEASES 196500 | PIANP | DISEASES 363 | AQP6 | DISEASES 113457 | TUBA3D | DISEASES 9622 | KLK4 | DISEASES 554 | AVPR2 | DISEASES 113675 | SDSL | DISEASES 26047 | CNTNAP2 | DISEASES 959 | CD40LG | DISEASES 9211 | LGI1 | DISEASES 116085 | SLC22A12 | DISEASES 551 | AVP | DISEASES 6557 | SLC12A1 | DISEASES 26278 | SACS | DISEASES 361 | AQP4 | DISEASES 11202 | KLK8 | DISEASES 210 | ALAD | DISEASES 6628 | SNRPB | DISEASES 3077 | HFE | DISEASES 111 | ADCY5 | DISEASES |
| Locus | (Waiting for update.) |
| Disease ID | 1309 |
|---|---|
| Disease | syndrome of inappropriate antidiuretic hormone |
| Integrated Phenotype | (Waiting for update.) |
| Text Mined Phenotype | HPO | Name | Sentences' Count(Total Phenotypes:20) HP:0002902 | Hyponatremia | 21 HP:0000873 | Diabetes insipidus | 2 HP:0001394 | Hepatic cirrhosis | 2 HP:0002861 | Melanoma | 2 HP:0001250 | Seizures | 1 HP:0000846 | Hypoadrenalism | 1 HP:0000083 | Renal insufficiency | 1 HP:0030731 | Carcinoma | 1 HP:0012125 | Prostate cancer | 1 HP:0030357 | Small cell lung carcinoma | 1 HP:0005521 | Disseminated intravascular coagulation | 1 HP:0002664 | Neoplasia | 1 HP:0100829 | Galactorrhoea | 1 HP:0003228 | High blood sodium levels | 1 HP:0003256 | Coagulopathy | 1 HP:0002948 | Fusion of vertebral bodies | 1 HP:0000821 | Underactive thyroid | 1 HP:0010934 | Increased urinary xanthine | 1 HP:0004395 | Malnutrition | 1 HP:0001287 | Meningitis | 1 |
| Disease ID | 1309 |
|---|---|
| Disease | syndrome of inappropriate antidiuretic hormone |
| Manually Symptom | (Waiting for update.) |
| Text Mined Symptom | (Waiting for update.) |
Manually Genotype(Total Text Mining Genotypes:0) |
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| (Waiting for update.) |
All Snps(Total Genotypes:0) | |
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| (Waiting for update.) | |
GWASdb Annotation(Total Genotypes:0) | |
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| (Waiting for update.) | |
GWASdb Snp Trait(Total Genotypes:0) | |
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| (Waiting for update.) | |
Mapped by lexical matching(Total Items:0) |
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| (Waiting for update.) |
Mapped by homologous gene(Total Items:0) |
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| (Waiting for update.) |
Chemical(Total Drugs:38) | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| CUI | ChemicalName | ChemicalID | CasRN | DiseaseName | DiseaseID | DirectEvidence | PubMedIDs | ||
| C0021141 | aminoglutethimide | D000616 | 125-84-8 | inappropriate adh syndrome | MESH:D007177 | marker/mechanism | 3801835 | ||
| C0021141 | amitriptyline | D000639 | 50-48-6 | inappropriate adh syndrome | MESH:D007177 | marker/mechanism | 20672238 | ||
| C0021141 | aripiprazole | D000068180 | - | inappropriate adh syndrome | MESH:D007177 | marker/mechanism | 16858173 | ||
| C0021141 | azithromycin | D017963 | 83905-01-5 | inappropriate adh syndrome | MESH:D007177 | marker/mechanism | 9391684 | ||
| C0021141 | carbamazepine | D002220 | 298-46-4 | inappropriate adh syndrome | MESH:D007177 | marker/mechanism | 10024990 | ||
| C0021141 | chlorambucil | D002699 | 305-03-3 | inappropriate adh syndrome | MESH:D007177 | marker/mechanism | 10037268 | ||
| C0021141 | chlorpromazine | D002746 | 50-53-3 | inappropriate adh syndrome | MESH:D007177 | marker/mechanism | 6640486 | ||
| C0021141 | citalopram | D015283 | 59729-33-8 | inappropriate adh syndrome | MESH:D007177 | marker/mechanism | 12075041 | ||
| C0021141 | clonidine | D003000 | 4205-90-7 | inappropriate adh syndrome | MESH:D007177 | marker/mechanism | 432171 | ||
| C0021141 | cyclophosphamide | D003520 | 50-18-0 | inappropriate adh syndrome | MESH:D007177 | marker/mechanism | 18988633 | ||
| C0021141 | cisplatin | D002945 | 15663-27-1 | inappropriate adh syndrome | MESH:D007177 | marker/mechanism | 15675594 | ||
| C0021141 | diclofenac | D004008 | 15307-86-5 | inappropriate adh syndrome | MESH:D007177 | marker/mechanism | 8443484 | ||
| C0021141 | enalapril | D004656 | 75847-73-3 | inappropriate adh syndrome | MESH:D007177 | marker/mechanism | 12087354 | ||
| C0021141 | ethionamide | D005000 | 536-33-4 | inappropriate adh syndrome | MESH:D007177 | marker/mechanism | 17240918 | ||
| C0021141 | fluorouracil | D005472 | 51-21-8 | inappropriate adh syndrome | MESH:D007177 | marker/mechanism | 20841948 | ||
| C0021141 | fluoxetine | D005473 | 54910-89-3 | inappropriate adh syndrome | MESH:D007177 | marker/mechanism | 16622573 | ||
| C0021141 | fluvoxamine | D016666 | 54739-18-3 | inappropriate adh syndrome | MESH:D007177 | marker/mechanism | 11195401 | ||
| C0021141 | haloperidol | D006220 | 52-86-8 | inappropriate adh syndrome | MESH:D007177 | marker/mechanism | 16999280 | ||
| C0021141 | ifosfamide | D007069 | 3778-73-2 | inappropriate adh syndrome | MESH:D007177 | marker/mechanism | 19542534 | ||
| C0021141 | imipramine | D007099 | 50-49-7 | inappropriate adh syndrome | MESH:D007177 | marker/mechanism | 1448636 | ||
| C0021141 | indomethacin | D007213 | 53-86-1 | inappropriate adh syndrome | MESH:D007177 | marker/mechanism | 1871284 | ||
| C0021141 | lorazepam | D008140 | 846-49-1 | inappropriate adh syndrome | MESH:D007177 | marker/mechanism | 3140958 | ||
| C0021141 | melphalan | D008558 | 148-82-3 | inappropriate adh syndrome | MESH:D007177 | marker/mechanism | 3965085 | ||
| C0021141 | methotrexate | D008727 | 1959/5/2 | inappropriate adh syndrome | MESH:D007177 | marker/mechanism | 20470218 | ||
| C0021141 | phenytoin | D010672 | 57-41-0 | inappropriate adh syndrome | MESH:D007177 | marker/mechanism | 1733741 | ||
| C0021141 | phenytoin | D010672 | 57-41-0 | inappropriate adh syndrome | MESH:D007177 | therapeutic | 11948390 | ||
| C0021141 | pramipexole | C061333 | - | inappropriate adh syndrome | MESH:D007177 | marker/mechanism | 16130408 | ||
| C0021141 | prochlorperazine | D011346 | 58-38-8 | inappropriate adh syndrome | MESH:D007177 | marker/mechanism | 7627260 | ||
| C0021141 | rifabutin | D017828 | 72559-06-9 | inappropriate adh syndrome | MESH:D007177 | marker/mechanism | 11310523 | ||
| C0021141 | tacrolimus | D016559 | 109581-93-3 | inappropriate adh syndrome | MESH:D007177 | marker/mechanism | 14604289 | ||
| C0021141 | theophylline | D013806 | 58-55-9 | inappropriate adh syndrome | MESH:D007177 | marker/mechanism | 12086552 | ||
| C0021141 | thiotepa | D013852 | 52-24-4 | inappropriate adh syndrome | MESH:D007177 | marker/mechanism | 10482945 | ||
| C0021141 | trihexyphenidyl | D014282 | 144-11-6 | inappropriate adh syndrome | MESH:D007177 | marker/mechanism | 9452348 | ||
| C0021141 | valproic acid | D014635 | 99-66-1 | inappropriate adh syndrome | MESH:D007177 | marker/mechanism | 11195262 | ||
| C0021141 | vinblastine | D014747 | 865-21-4 | inappropriate adh syndrome | MESH:D007177 | marker/mechanism | 3686684 | ||
| C0021141 | vincristine | D014750 | - | inappropriate adh syndrome | MESH:D007177 | marker/mechanism | 10660739 | ||
| C0021141 | vindesine | D014751 | 53643-48-4 | inappropriate adh syndrome | MESH:D007177 | marker/mechanism | 2053780 | ||
| C0021141 | vinorelbine | C030852 | 71486-22-1 | inappropriate adh syndrome | MESH:D007177 | marker/mechanism | 17848819 | ||
FDA approved drug and dosage information(Total Drugs:0) | |
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| (Waiting for update.) | |
FDA labeling changes(Total Drugs:0) | |
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| (Waiting for update.) | |