PedAM

Pediatric Disease Annotations & Medicines


	superior vena cava syndrome

Disease ID	1177
Disease	superior vena cava syndrome
Definition	A condition that occurs when the obstruction of the thin-walled SUPERIOR VENA CAVA interrupts blood flow from the head, upper extremities, and thorax to the RIGHT ATRIUM. Obstruction can be caused by NEOPLASMS; THROMBOSIS; ANEURYSM; or external compression. The syndrome is characterized by swelling and/or CYANOSIS of the face, neck, and upper arms.
Synonym	cava superior syndromes vena caval obstruction superior vena superior vena cava obstruction superior vena cava syndrome (disorder) superior vena cava syndrome [disease/finding] superior vena caval obstruction superior vena caval syndrome svc - superior vena cava obstruction svc obstruction svc syndrome svco - superior vena cava obstruction vena cava obstruction, superior vena cava superior syndrome
UMLS	C0038833
MeSH	D013479
SNOMED-CT	SNOMEDCT_US_2016_09_01:63363004
Comorbidity	UMLS \| Disease \| Sentences' Count(Total Sentences:23) C0242379 \| lung cancer \| 4 C0037315 \| sleep apnea \| 1 C0520679 \| obstructive sleep apnea \| 1 C0023448 \| lymphoid leukemia \| 1 C0007115 \| thyroid cancer \| 1 C0334277 \| metastatic adenocarcinoma \| 1 C0001418 \| adenocarcinoma \| 1 C0023418 \| leukemia \| 1 C0032461 \| polycythemia \| 1 C0149925 \| small cell lung cancer \| 1 C0007115 \| thyroid ca \| 1 C0039538 \| teratoma \| 1 C0032463 \| polycythemia vera \| 1 C0553580 \| ewing's sarcoma \| 1 C0025064 \| mediastinitis \| 1 C0007131 \| non-small cell lung cancer \| 1 C0036631 \| seminoma \| 1 C0027809 \| schwannoma \| 1 C0206695 \| neuroendocrine carcinoma \| 1 C0040053 \| thrombosis \| 1 C0004943 \| behcet's disease \| 1 C0023449 \| acute lymphoid leukemia \| 1 C0151740 \| raised intracranial pressure \| 1
Curated Gene	Entrez_id \| Symbol \| Resource(Total Genes:1) PTHLH \| 5744 \| CTD_human
Inferring Gene	(Waiting for update.)
Text Mined Gene	(Waiting for update.)
Locus	(Waiting for update.)

Disease ID	1177
Disease	superior vena cava syndrome
Integrated Phenotype	(Waiting for update.)
Text Mined Phenotype	HPO \| Name \| Sentences' Count(Total Phenotypes:21) HP:0001050 \| Plethora \| 1 HP:0005160 \| Total anomalous pulmonary venous return \| 1 HP:0012254 \| Ewing's sarcoma \| 1 HP:0002664 \| Neoplasia \| 1 HP:0005526 \| Lymphoid leukemia \| 1 HP:0011855 \| Pharyngeal edema \| 1 HP:0002617 \| Aneurysmal dilatation \| 1 HP:0011720 \| Type 2 total anomalous pulmonary venous connection \| 1 HP:0010535 \| Sleep apnea \| 1 HP:0030357 \| Small cell lung carcinoma \| 1 HP:0002870 \| Obstructive sleep apnea \| 1 HP:0002104 \| Absence of spontaneous respiration \| 1 HP:0002835 \| Aspiration \| 1 HP:0030358 \| Non-small cell lung carcinoma \| 1 HP:0001901 \| Abnormally shaped erythrocytes \| 1 HP:0001693 \| Cardiac shunt \| 1 HP:0001694 \| Right-to-left shunt \| 1 HP:0001909 \| Leukemia \| 1 HP:0006721 \| Acute lymphocytic leukemia \| 1 HP:0000969 \| Dropsy \| 1 HP:0100008 \| Schwann cell tumour \| 1

Disease ID	1177
Disease	superior vena cava syndrome
Manually Symptom	UMLS \| Name(Total Manually Symptoms:12) C2364324 \| increased intracranial pressure C1527311 \| brain swelling C0684249 \| lung carcinoma C0520679 \| obstructive sleep apnea syndrome C0494752 \| diaphragmatic hernia C0270716 \| acquired hydrocephalus C0263361 \| psoriasis vulgaris C0032227 \| pleural effusions C0024141 \| systemic lupus erythematosus C0014867 \| esophageal varices C0013363 \| dysautonomia C0010520 \| cyanosis
Text Mined Symptom	(Waiting for update.)

Manually Genotype(Total Text Mining Genotypes:0)
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All Snps(Total Genotypes:0)
(Waiting for update.)

GWASdb Annotation(Total Genotypes:0)
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GWASdb Snp Trait(Total Genotypes:0)
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Mapped by lexical matching(Total Items:0)
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Mapped by homologous gene(Total Items:0)
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Chemical(Total Drugs:5)
CUI	ChemicalName	ChemicalID	CasRN	DiseaseName	DiseaseID	DirectEvidence	PubMedIDs
C0038833	cyclophosphamide	D003520	50-18-0	superior vena cava syndrome	MESH:D013479	therapeutic	19770526
C0038833	pegaspargase	C042705	-	superior vena cava syndrome	MESH:D013479	marker/mechanism	19018221
C0038833	propylthiouracil	D011441	51-52-5	superior vena cava syndrome	MESH:D013479	marker/mechanism	7471870
C0038833	vincristine	D014750	-	superior vena cava syndrome	MESH:D013479	marker/mechanism	19018221
C0038833	vincristine	D014750	-	superior vena cava syndrome	MESH:D013479	therapeutic	19770526

FDA approved drug and dosage information(Total Drugs:0)
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FDA labeling changes(Total Drugs:0)
(Waiting for update.)

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