PedAM

Pediatric Disease Annotations & Medicines


	substance dependence

Disease ID	1740
Disease	substance dependence
Synonym	addiction chemical addiction, substance addictions substance chemical addiction chemical dependence chemical dependencies chemical dependency dependence substance dependence substances dependence, substance substance addiction substance dependence, nos
DOID	DOID:9973
UMLS	C0038580
Comorbidity	UMLS \| Disease \| Sentences' Count(Total Sentences:11) C0011570 \| depression \| 4 C0036341 \| schizophrenia \| 3 C0033975 \| psychosis \| 2 C0006370 \| bulimia \| 1 C0003467 \| anxiety \| 1 C0030662 \| pathological gambling \| 1 C0041696 \| major depressive disorder \| 1 C2267227 \| bulimia nervosa \| 1 C0001973 \| alcoholism \| 1 C1510472 \| drug dependence \| 1 C0028768 \| obsessive-compulsive disorder \| 1
Curated Gene	Entrez_id \| Symbol \| Resource(Total Genes:4) PKNOX2 \| 63876 \| GWASCAT PLEKHG1 \| 57480 \| GWASCAT SH3BP5-AS1 \| 100505696 \| GWASCAT SH3BP5 \| 9467 \| GWASCAT
Inferring Gene	Entrez_id \| Symbol \| Resource(Total Genes:2) 4988 \| OPRM1 \| infer 63876 \| PKNOX2 \| infer
Text Mined Gene	Entrez_id \| Symbol \| Score \| Resource(Total Genes:593) 2554 \| GABRA1 \| DISEASES 84245 \| MRI1 \| DISEASES 5685 \| PSMA4 \| DISEASES 1815 \| DRD4 \| DISEASES 6343 \| SCT \| DISEASES 9552 \| SPAG7 \| DISEASES 26575 \| RGS17 \| DISEASES 9942 \| XYLB \| DISEASES 124 \| ADH1A \| DISEASES 9342 \| SNAP29 \| DISEASES 6948 \| TCN2 \| DISEASES 402055 \| SRRD \| DISEASES 5173 \| PDYN \| DISEASES 5020 \| OXT \| DISEASES 2742 \| GLRA2 \| DISEASES 84560 \| MT4 \| DISEASES 6530 \| SLC6A2 \| DISEASES 83988 \| NCALD \| DISEASES 3972 \| LHB \| DISEASES 6449 \| SGTA \| DISEASES 6511 \| SLC1A6 \| DISEASES 973 \| CD79A \| DISEASES 6822 \| SULT2A1 \| DISEASES 6142 \| RPL18A \| DISEASES 218 \| ALDH3A1 \| DISEASES 6347 \| CCL2 \| DISEASES 5539 \| PPY \| DISEASES 55907 \| CMAS \| DISEASES 9896 \| FIG4 \| DISEASES 9450 \| LY86 \| DISEASES 1839 \| HBEGF \| DISEASES 2908 \| NR3C1 \| DISEASES 8440 \| NCK2 \| DISEASES 5967 \| REG1A \| DISEASES 4985 \| OPRD1 \| DISEASES 55640 \| FLVCR2 \| DISEASES 847 \| CAT \| DISEASES 2693 \| GHSR \| DISEASES 114784 \| CSMD2 \| DISEASES 4852 \| NPY \| DISEASES 5552 \| SRGN \| DISEASES 2166 \| FAAH \| DISEASES 55786 \| ZNF415 \| DISEASES 57699 \| CPNE5 \| DISEASES 79143 \| MBOAT7 \| DISEASES 2354 \| FOSB \| DISEASES 2678 \| GGT1 \| DISEASES 8484 \| GALR3 \| DISEASES 50833 \| TAS2R16 \| DISEASES 7166 \| TPH1 \| DISEASES 1603 \| DAD1 \| DISEASES 57053 \| CHRNA10 \| DISEASES 3630 \| INS \| DISEASES 259232 \| NALCN \| DISEASES 11024 \| LILRA1 \| DISEASES 348 \| APOE \| DISEASES 55821 \| ALLC \| DISEASES 23039 \| XPO7 \| DISEASES 1571 \| CYP2E1 \| DISEASES 55902 \| ACSS2 \| DISEASES 8572 \| PDLIM4 \| DISEASES 84152 \| PPP1R1B \| DISEASES 113 \| ADCY7 \| DISEASES 8864 \| PER2 \| DISEASES 1401 \| CRP \| DISEASES 222 \| ALDH3B2 \| DISEASES 4922 \| NTS \| DISEASES 57578 \| UNC79 \| DISEASES 51124 \| IER3IP1 \| DISEASES 747 \| DAGLA \| DISEASES 29969 \| MDFIC \| DISEASES 80896 \| NPL \| DISEASES 1144 \| CHRND \| DISEASES 3357 \| HTR2B \| DISEASES 80704 \| SLC19A3 \| DISEASES 160428 \| ALDH1L2 \| DISEASES 3569 \| IL6 \| DISEASES 9568 \| GABBR2 \| DISEASES 9177 \| HTR3B \| DISEASES 9360 \| PPIG \| DISEASES 1134 \| CHRNA1 \| DISEASES 6857 \| SYT1 \| DISEASES 55068 \| ENOX1 \| DISEASES 27340 \| UTP20 \| DISEASES 6532 \| SLC6A4 \| DISEASES 217 \| ALDH2 \| DISEASES 1143 \| CHRNB4 \| DISEASES 23469 \| PHF3 \| DISEASES 6505 \| SLC1A1 \| DISEASES 8787 \| RGS9 \| DISEASES 55798 \| METTL2B \| DISEASES 4969 \| OGN \| DISEASES 25939 \| SAMHD1 \| DISEASES 2033 \| EP300 \| DISEASES 2906 \| GRIN2D \| DISEASES 3553 \| IL1B \| DISEASES 8273 \| SLC10A3 \| DISEASES 4528 \| MTIF2 \| DISEASES 114879 \| OSBPL5 \| DISEASES 5067 \| CNTN3 \| DISEASES 390 \| RND3 \| DISEASES 84708 \| LNX1 \| DISEASES 1001 \| CDH3 \| DISEASES 29899 \| GPSM2 \| DISEASES 8540 \| AGPS \| DISEASES 1371 \| CPOX \| DISEASES 2557 \| GABRA4 \| DISEASES 2892 \| GRIA3 \| DISEASES 64579 \| NDST4 \| DISEASES 1421 \| CRYGD \| DISEASES 590 \| BCHE \| DISEASES 2891 \| GRIA2 \| DISEASES 5443 \| POMC \| DISEASES 3781 \| KCNN2 \| DISEASES 11343 \| MGLL \| DISEASES 5924 \| RASGRF2 \| DISEASES 6507 \| SLC1A3 \| DISEASES 56311 \| ANKRD7 \| DISEASES 2568 \| GABRP \| DISEASES 55825 \| PECR \| DISEASES 11112 \| HIBADH \| DISEASES 127 \| ADH4 \| DISEASES 4986 \| OPRK1 \| DISEASES 51083 \| GAL \| DISEASES 55749 \| CCAR1 \| DISEASES 5286 \| PIK3C2A \| DISEASES 56938 \| ARNTL2 \| DISEASES 85437 \| ZCRB1 \| DISEASES 7112 \| TMPO \| DISEASES 8620 \| NPFF \| DISEASES 85439 \| STON2 \| DISEASES 5373 \| PMM2 \| DISEASES 23174 \| ZCCHC14 \| DISEASES 10351 \| ABCA8 \| DISEASES 409 \| ARRB2 \| DISEASES 147381 \| CBLN2 \| DISEASES 54858 \| PGPEP1 \| DISEASES 6531 \| SLC6A3 \| DISEASES 5141 \| PDE4A \| DISEASES 149111 \| CNIH3 \| DISEASES 5972 \| REN \| DISEASES 805 \| CALM2 \| DISEASES 80731 \| THSD7B \| DISEASES 130749 \| CPO \| DISEASES 10550 \| ARL6IP5 \| DISEASES 29114 \| TAGLN3 \| DISEASES 8001 \| GLRA3 \| DISEASES 6715 \| SRD5A1 \| DISEASES 635 \| BHMT \| DISEASES 1393 \| CRHBP \| DISEASES 2559 \| GABRA6 \| DISEASES 2561 \| GABRB2 \| DISEASES 2830 \| GPR6 \| DISEASES 6581 \| SLC22A3 \| DISEASES 92129 \| RIPPLY1 \| DISEASES 3358 \| HTR2C \| DISEASES 6570 \| SLC18A1 \| DISEASES 8973 \| CHRNA6 \| DISEASES 9705 \| ST18 \| DISEASES 1392 \| CRH \| DISEASES 10280 \| SIGMAR1 \| DISEASES 4915 \| NTRK2 \| DISEASES 64106 \| NPFFR1 \| DISEASES 6506 \| SLC1A2 \| DISEASES 3995 \| FADS3 \| DISEASES 9415 \| FADS2 \| DISEASES 9538 \| EI24 \| DISEASES 10326 \| SIRPB1 \| DISEASES 2904 \| GRIN2B \| DISEASES 3176 \| HNMT \| DISEASES 150 \| ADRA2A \| DISEASES 11098 \| PRSS23 \| DISEASES 9871 \| SEC24D \| DISEASES 84076 \| TKTL2 \| DISEASES 23657 \| SLC7A11 \| DISEASES 636 \| BICD1 \| DISEASES 5741 \| PTH \| DISEASES 814 \| CAMK4 \| DISEASES 3087 \| HHEX \| DISEASES 2911 \| GRM1 \| DISEASES 6328 \| SCN3A \| DISEASES 518 \| ATP5G3 \| DISEASES 351 \| APP \| DISEASES 27123 \| DKK2 \| DISEASES 761 \| CA3 \| DISEASES 2890 \| GRIA1 \| DISEASES 114 \| ADCY8 \| DISEASES 6750 \| SST \| DISEASES 3361 \| HTR5A \| DISEASES 776 \| CACNA1D \| DISEASES 3763 \| KCNJ6 \| DISEASES 9162 \| DGKI \| DISEASES 1142 \| CHRNB3 \| DISEASES 8659 \| ALDH4A1 \| DISEASES 1636 \| ACE \| DISEASES 808 \| CALM3 \| DISEASES 10841 \| FTCD \| DISEASES 2905 \| GRIN2C \| DISEASES 3060 \| HCRT \| DISEASES 1742 \| DLG4 \| DISEASES 146849 \| CCDC42 \| DISEASES 115 \| ADCY9 \| DISEASES 114905 \| C1QTNF7 \| DISEASES 2565 \| GABRG1 \| DISEASES 2560 \| GABRB1 \| DISEASES 886 \| CCKAR \| DISEASES 3490 \| IGFBP7 \| DISEASES 213 \| ALB \| DISEASES 7349 \| UCN \| DISEASES 7123 \| CLEC3B \| DISEASES 128 \| ADH5 \| DISEASES 327 \| APEH \| DISEASES 4724 \| NDUFS4 \| DISEASES 6690 \| SPINK1 \| DISEASES 9607 \| CARTPT \| DISEASES 221955 \| DAGLB \| DISEASES 8601 \| RGS20 \| DISEASES 107 \| ADCY1 \| DISEASES 216 \| ALDH1A1 \| DISEASES 115825 \| WDFY2 \| DISEASES 63876 \| PKNOX2 \| DISEASES 6571 \| SLC18A2 \| DISEASES 2562 \| GABRB3 \| DISEASES 1138 \| CHRNA5 \| DISEASES 339302 \| CPLX4 \| DISEASES 2587 \| GALR1 \| DISEASES 89832 \| CHRFAM7A \| DISEASES 113201 \| CASC4 \| DISEASES 1548 \| CYP2A6 \| DISEASES 10653 \| SPINT2 \| DISEASES 956 \| ENTPD3 \| DISEASES 4054 \| LTBP3 \| DISEASES 51435 \| SCARA3 \| DISEASES 5368 \| PNOC \| DISEASES 5617 \| PRL \| DISEASES 3479 \| IGF1 \| DISEASES 23440 \| OTP \| DISEASES 51181 \| DCXR \| DISEASES 7200 \| TRH \| DISEASES 6869 \| TACR1 \| DISEASES 53343 \| NUDT9 \| DISEASES 3094 \| HINT1 \| DISEASES 1140 \| CHRNB1 \| DISEASES 9455 \| HOMER2 \| DISEASES 1816 \| DRD5 \| DISEASES 2915 \| GRM5 \| DISEASES 2353 \| FOS \| DISEASES 1128 \| CHRM1 \| DISEASES 125 \| ADH1B \| DISEASES 255239 \| ANKK1 \| DISEASES 51778 \| MYOZ2 \| DISEASES 8462 \| KLF11 \| DISEASES 9451 \| EIF2AK3 \| DISEASES 152189 \| CMTM8 \| DISEASES 3354 \| HTR1E \| DISEASES 2147 \| F2 \| DISEASES 134 \| ADORA1 \| DISEASES 5644 \| PRSS1 \| DISEASES 9575 \| CLOCK \| DISEASES 5340 \| PLG \| DISEASES 9690 \| UBE3C \| DISEASES 3265 \| HRAS \| DISEASES 6868 \| ADAM17 \| DISEASES 27165 \| GLS2 \| DISEASES 9024 \| BRSK2 \| DISEASES 5598 \| MAPK7 \| DISEASES 836 \| CASP3 \| DISEASES 2944 \| GSTM1 \| DISEASES 374879 \| ZNF699 \| DISEASES 7368 \| UGT8 \| DISEASES 5978 \| REST \| DISEASES 160762 \| CCDC63 \| DISEASES 133522 \| PPARGC1B \| DISEASES 3952 \| LEP \| DISEASES 55584 \| CHRNA9 \| DISEASES 79822 \| ARHGAP28 \| DISEASES 3352 \| HTR1D \| DISEASES 64689 \| GORASP1 \| DISEASES 57453 \| DSCAML1 \| DISEASES 1136 \| CHRNA3 \| DISEASES 26251 \| KCNG2 \| DISEASES 1310 \| COL19A1 \| DISEASES 3350 \| HTR1A \| DISEASES 4684 \| NCAM1 \| DISEASES 27319 \| BHLHE22 \| DISEASES 57722 \| IGDCC4 \| DISEASES 1129 \| CHRM2 \| DISEASES 10938 \| EHD1 \| DISEASES 28232 \| SLCO3A1 \| DISEASES 6863 \| TAC1 \| DISEASES 162282 \| ANKFN1 \| DISEASES 10611 \| PDLIM5 \| DISEASES 119682 \| OR51L1 \| DISEASES 3992 \| FADS1 \| DISEASES 23212 \| RRS1 \| DISEASES 170572 \| HTR3C \| DISEASES 10194 \| TSHZ1 \| DISEASES 23362 \| PSD3 \| DISEASES 284358 \| MAMSTR \| DISEASES 5179 \| PENK \| DISEASES 5021 \| OXTR \| DISEASES 1555 \| CYP2B6 \| DISEASES 66000 \| TMEM108 \| DISEASES 57010 \| CABP4 \| DISEASES 400359 \| C15orf53 \| DISEASES 27430 \| MAT2B \| DISEASES 4094 \| MAF \| DISEASES 4661 \| MYT1 \| DISEASES 1812 \| DRD1 \| DISEASES 1606 \| DGKA \| DISEASES 125061 \| AFMID \| DISEASES 121278 \| TPH2 \| DISEASES 256435 \| ST6GALNAC3 \| DISEASES 5121 \| PCP4 \| DISEASES 8811 \| GALR2 \| DISEASES 2894 \| GRID1 \| DISEASES 254887 \| ZDHHC23 \| DISEASES 2520 \| GAST \| DISEASES 2567 \| GABRG3 \| DISEASES 2903 \| GRIN2A \| DISEASES 23762 \| OSBP2 \| DISEASES 4887 \| NPY2R \| DISEASES 1553 \| CYP2A13 \| DISEASES 5813 \| PURA \| DISEASES 91582 \| RPS19BP1 \| DISEASES 9001 \| HAP1 \| DISEASES 255061 \| TAC4 \| DISEASES 9456 \| HOMER1 \| DISEASES 2626 \| GATA4 \| DISEASES 5787 \| PTPRB \| DISEASES 10810 \| WASF3 \| DISEASES 51738 \| GHRL \| DISEASES 285242 \| HTR3E \| DISEASES 887 \| CCKBR \| DISEASES 2558 \| GABRA5 \| DISEASES 885 \| CCK \| DISEASES 135 \| ADORA2A \| DISEASES 4987 \| OPRL1 \| DISEASES 1103 \| CHAT \| DISEASES 79157 \| MFSD11 \| DISEASES 3988 \| LIPA \| DISEASES 4842 \| NOS1 \| DISEASES 4835 \| NQO2 \| DISEASES 57142 \| RTN4 \| DISEASES 1576 \| CYP3A4 \| DISEASES 3363 \| HTR7 \| DISEASES 2289 \| FKBP5 \| DISEASES 3983 \| ABLIM1 \| DISEASES 6622 \| SNCA \| DISEASES 9369 \| NRXN3 \| DISEASES 9679 \| FAM53B \| DISEASES 64682 \| ANAPC1 \| DISEASES 3266 \| ERAS \| DISEASES 23076 \| RRP1B \| DISEASES 4889 \| NPY5R \| DISEASES 11188 \| NISCH \| DISEASES 222236 \| NAPEPLD \| DISEASES 9639 \| ARHGEF10 \| DISEASES 4128 \| MAOA \| DISEASES 1395 \| CRHR2 \| DISEASES 4306 \| NR3C2 \| DISEASES 84062 \| DTNBP1 \| DISEASES 1508 \| CTSB \| DISEASES 10079 \| ATP9A \| DISEASES 3146 \| HMGB1 \| DISEASES 26053 \| AUTS2 \| DISEASES 220004 \| PPP1R32 \| DISEASES 2918 \| GRM8 \| DISEASES 401024 \| FSIP2 \| DISEASES 4929 \| NR4A2 \| DISEASES 224 \| ALDH3A2 \| DISEASES 54820 \| NDE1 \| DISEASES 10307 \| APBB3 \| DISEASES 65992 \| DDRGK1 \| DISEASES 309 \| ANXA6 \| DISEASES 2534 \| FYN \| DISEASES 223 \| ALDH9A1 \| DISEASES 2335 \| FN1 \| DISEASES 50618 \| ITSN2 \| DISEASES 145741 \| C2CD4A \| DISEASES 3359 \| HTR3A \| DISEASES 79710 \| MORC4 \| DISEASES 5265 \| SERPINA1 \| DISEASES 10438 \| C1D \| DISEASES 3240 \| HP \| DISEASES 3476 \| IGBP1 \| DISEASES 219844 \| HYLS1 \| DISEASES 2555 \| GABRA2 \| DISEASES 23237 \| ARC \| DISEASES 801 \| CALM1 \| DISEASES 135250 \| RAET1E \| DISEASES 60 \| ACTB \| DISEASES 55691 \| FRMD4A \| DISEASES 10865 \| ARID5A \| DISEASES 2917 \| GRM7 \| DISEASES 1121 \| CHM \| DISEASES 5992 \| RFX4 \| DISEASES 1644 \| DDC \| DISEASES 2571 \| GAD1 \| DISEASES 79694 \| MANEA \| DISEASES 8936 \| WASF1 \| DISEASES 57016 \| AKR1B10 \| DISEASES 387129 \| NPSR1 \| DISEASES 4192 \| MDK \| DISEASES 79947 \| DHDDS \| DISEASES 1825 \| DSC3 \| DISEASES 4311 \| MME \| DISEASES 6536 \| SLC6A9 \| DISEASES 1565 \| CYP2D6 \| DISEASES 55833 \| UBAP2 \| DISEASES 23560 \| GTPBP4 \| DISEASES 8532 \| CPZ \| DISEASES 56477 \| CCL28 \| DISEASES 1312 \| COMT \| DISEASES 460 \| ASTN1 \| DISEASES 4886 \| NPY1R \| DISEASES 115265 \| DDIT4L \| DISEASES 10724 \| MGEA5 \| DISEASES 1813 \| DRD2 \| DISEASES 8863 \| PER3 \| DISEASES 116443 \| GRIN3A \| DISEASES 63901 \| FAM111A \| DISEASES 2913 \| GRM3 \| DISEASES 23038 \| WDTC1 \| DISEASES 4139 \| MARK1 \| DISEASES 81788 \| NUAK2 \| DISEASES 127833 \| SYT2 \| DISEASES 2328 \| FMO3 \| DISEASES 3765 \| KCNJ9 \| DISEASES 632 \| BGLAP \| DISEASES 154215 \| NKAIN2 \| DISEASES 1141 \| CHRNB2 \| DISEASES 64077 \| LHPP \| DISEASES 1268 \| CNR1 \| DISEASES 4803 \| NGF \| DISEASES 2316 \| FLNA \| DISEASES 3351 \| HTR1B \| DISEASES 22854 \| NTNG1 \| DISEASES 1137 \| CHRNA4 \| DISEASES 4923 \| NTSR1 \| DISEASES 959 \| CD40LG \| DISEASES 7803 \| PTP4A1 \| DISEASES 58511 \| DNASE2B \| DISEASES 3062 \| HCRTR2 \| DISEASES 84251 \| SGIP1 \| DISEASES 56889 \| TM9SF3 \| DISEASES 1557 \| CYP2C19 \| DISEASES 2902 \| GRIN1 \| DISEASES 56654 \| NPDC1 \| DISEASES 2030 \| SLC29A1 \| DISEASES 10420 \| TESK2 \| DISEASES 10718 \| NRG3 \| DISEASES 60598 \| KCNK15 \| DISEASES 1759 \| DNM1 \| DISEASES 2899 \| GRIK3 \| DISEASES 83931 \| STK40 \| DISEASES 3061 \| HCRTR1 \| DISEASES 347735 \| SERINC2 \| DISEASES 79570 \| NKAIN1 \| DISEASES 4736 \| RPL10A \| DISEASES 23673 \| STX12 \| DISEASES 7099 \| TLR4 \| DISEASES 1269 \| CNR2 \| DISEASES 8518 \| IKBKAP \| DISEASES 4524 \| MTHFR \| DISEASES 2550 \| GABBR1 \| DISEASES 1325 \| CORT \| DISEASES 219 \| ALDH1B1 \| DISEASES 4129 \| MAOB \| DISEASES 84912 \| SLC35B4 \| DISEASES 6497 \| SKI \| DISEASES 3356 \| HTR2A \| DISEASES 4897 \| NRCAM \| DISEASES 2625 \| GATA3 \| DISEASES 9617 \| MTRF1 \| DISEASES 387755 \| INSC \| DISEASES 551 \| AVP \| DISEASES 8544 \| PIR \| DISEASES 114131 \| UCN3 \| DISEASES 4676 \| NAP1L4 \| DISEASES 92949 \| ADAMTSL1 \| DISEASES 689 \| BTF3 \| DISEASES 8777 \| MPDZ \| DISEASES 7054 \| TH \| DISEASES 2618 \| GART \| DISEASES 9751 \| SNPH \| DISEASES 2788 \| GNG7 \| DISEASES 1010 \| CDH12 \| DISEASES 200909 \| HTR3D \| DISEASES 4155 \| MBP \| DISEASES 361 \| AQP4 \| DISEASES 1814 \| DRD3 \| DISEASES 4336 \| MOBP \| DISEASES 2617 \| GARS \| DISEASES 1146 \| CHRNG \| DISEASES 406 \| ARNTL \| DISEASES 9290 \| GPR55 \| DISEASES 4216 \| MAP3K4 \| DISEASES 9244 \| CRLF1 \| DISEASES 1621 \| DBH \| DISEASES 5803 \| PTPRZ1 \| DISEASES 51520 \| LARS \| DISEASES 130 \| ADH6 \| DISEASES 594855 \| CPLX3 \| DISEASES 2912 \| GRM2 \| DISEASES 174 \| AFP \| DISEASES 91452 \| ACBD5 \| DISEASES 137872 \| ADHFE1 \| DISEASES 55174 \| INTS10 \| DISEASES 2047 \| EPHB1 \| DISEASES 594857 \| NPS \| DISEASES 1394 \| CRHR1 \| DISEASES 815 \| CAMK2A \| DISEASES 344022 \| NOTO \| DISEASES 84570 \| COL25A1 \| DISEASES 2897 \| GRIK1 \| DISEASES 24144 \| TFIP11 \| DISEASES 643418 \| LIPN \| DISEASES 1135 \| CHRNA2 \| DISEASES 9378 \| NRXN1 \| DISEASES 728441 \| GGT2 \| DISEASES 3778 \| KCNMA1 \| DISEASES 7018 \| TF \| DISEASES 2570 \| GABRR2 \| DISEASES 210 \| ALAD \| DISEASES 10213 \| PSMD14 \| DISEASES 51194 \| IPO11 \| DISEASES 130576 \| LYPD6B \| DISEASES 501 \| ALDH7A1 \| DISEASES 2641 \| GCG \| DISEASES 1385 \| CREB1 \| DISEASES 348180 \| CTU2 \| DISEASES 285175 \| UNC80 \| DISEASES 375248 \| ANKRD36 \| DISEASES 4988 \| OPRM1 \| DISEASES 113235 \| SLC46A1 \| DISEASES 10163 \| WASF2 \| DISEASES 117579 \| RLN3 \| DISEASES 7124 \| TNF \| DISEASES 8910 \| SGCE \| DISEASES 159371 \| SLC35G1 \| DISEASES 7086 \| TKT \| DISEASES 79827 \| CLMP \| DISEASES 1139 \| CHRNA7 \| DISEASES 1012 \| CDH13 \| DISEASES 2668 \| GDNF \| DISEASES 2566 \| GABRG2 \| DISEASES 57579 \| FAM135A \| DISEASES 23270 \| TSPYL4 \| DISEASES 3586 \| IL10 \| DISEASES 54475 \| NLE1 \| DISEASES 627 \| BDNF \| DISEASES 3077 \| HFE \| DISEASES 8568 \| RRP1 \| DISEASES 79068 \| FTO \| DISEASES 85476 \| GFM1 \| DISEASES 55799 \| CACNA2D3 \| DISEASES 1020 \| CDK5 \| DISEASES 131 \| ADH7 \| DISEASES 79772 \| MCTP1 \| DISEASES 346007 \| EYS \| DISEASES 285605 \| DTWD2 \| DISEASES 2533 \| FYB \| DISEASES 55656 \| INTS8 \| DISEASES 9312 \| KCNB2 \| DISEASES 54622 \| ARL15 \| DISEASES 54970 \| TTC12 \| DISEASES 9152 \| SLC6A5 \| DISEASES 64478 \| CSMD1 \| DISEASES 27164 \| SALL3 \| DISEASES 51550 \| CINP \| DISEASES 51802 \| ASIC5 \| DISEASES 9 \| NAT1 \| DISEASES 6999 \| TDO2 \| DISEASES 8972 \| MGAM \| DISEASES 5726 \| TAS2R38 \| DISEASES 79611 \| ACSS3 \| DISEASES 283450 \| HECTD4 \| DISEASES 4329 \| ALDH6A1 \| DISEASES 9628 \| RGS6 \| DISEASES 8742 \| TNFSF12 \| DISEASES 2108 \| ETFA \| DISEASES 728276 \| CLEC19A \| DISEASES 124975 \| GGT6 \| DISEASES 64772 \| ENGASE \| DISEASES 11201 \| POLI \| DISEASES 391104 \| VHLL \| DISEASES 6625 \| SNRNP70 \| DISEASES 339789 \| LINC00299 \| DISEASES 100128782 \| LINC00476 \| DISEASES 339894 \| LINC00880 \| DISEASES 101927715 \| LINC01029 \| DISEASES 257000 \| TINCR \| DISEASES
Locus	(Waiting for update.)

Disease ID	1740
Disease	substance dependence
Integrated Phenotype	(Waiting for update.)
Text Mined Phenotype	HPO \| Name \| Sentences' Count(Total Phenotypes:14) HP:0000716 \| Depression \| 4 HP:0100753 \| Schizophrenia \| 3 HP:0100543 \| Cognitive deficits \| 2 HP:0000709 \| Psychosis \| 2 HP:0000708 \| Behavioral problems \| 2 HP:0007185 \| Loss of consciousness \| 2 HP:0000722 \| Obsessive compulsive disorder \| 1 HP:0000718 \| Aggressive behaviour \| 1 HP:0012075 \| Personality disorder \| 1 HP:0012532 \| Chronic pain \| 1 HP:0000739 \| Anxiety \| 1 HP:0000713 \| Agitation \| 1 HP:0100710 \| Impulsivity \| 1 HP:0100739 \| Binge and purge \| 1

Disease ID	1740
Disease	substance dependence
Manually Symptom	(Waiting for update.)
Text Mined Symptom	(Waiting for update.)

Manually Genotype(Total Text Mining Genotypes:0)
(Waiting for update.)

All Snps(Total Genotypes:17)
snpId	pubmedId	geneId	geneSymbol	diseaseId	sourceId	sentence	score	Year	geneSymbol_dbSNP	CHROMOSOME	POS	REF	ALT
rs12284594	21298047	63876	PKNOX2	umls:C0038580	GWASCAT	The nuclear transcription factor PKNOX2 is a candidate gene for substance dependence in European-origin women.	0.122638474	2011	PKNOX2	11	125309957	A	G
rs1229984	21497796	125	ADH1B	umls:C0038580	BeFree	A variant of the ADH1B gene (rs1229984 or Arg48His; previously referred to as Arg [1] and His [1]) has been reported to be associated with reduced rates of alcohol and drug dependence.	0.000542884	2011	ADH1B	4	99318162	T	C
rs1318937	22488850	9467	SH3BP5	umls:C0038580	GWASCAT	Genome-wide search for replicable risk gene regions in alcohol and nicotine co-dependence.	0.12	2012	SH3BP5;SH3BP5-AS1	3	15253857	A	G
rs1318937	22488850	100505696	SH3BP5-AS1	umls:C0038580	GWASCAT	Genome-wide search for replicable risk gene regions in alcohol and nicotine co-dependence.	0.12	2012	SH3BP5;SH3BP5-AS1	3	15253857	A	G
rs17427389	22488850	57480	PLEKHG1	umls:C0038580	GWASCAT	Genome-wide search for replicable risk gene regions in alcohol and nicotine co-dependence.	0.12	2012	PLEKHG1	6	150841979	G	A
rs1799971	23543091	4988	OPRM1	umls:C0038580	BeFree	A single-nucleotide polymorphism (SNP) within the OPRM1 gene, A118G, leading to an amino acid change (Asn40Asp) in the extracellular portion of the receptor, has been implicated in alcoholism as well as in drug addiction, pain sensitivity and stress response, and in animal and human studies relates to the alcohol-dependent phenotype as well as to the treatment response to the µ-opioid antagonist naltrexone.	0.014158585	2014	OPRM1	6	154039662	A	G
rs1799971	16387451	4988	OPRM1	umls:C0038580	BeFree	Association of an Asn40Asp (A118G) polymorphism in the mu-opioid receptor gene with substance dependence: a meta-analysis.	0.014158585	2006	OPRM1	6	154039662	A	G
rs1799971	22744787	4988	OPRM1	umls:C0038580	BeFree	A significant association was observed between A118G polymorphism in μ opioid receptor gene and drug addiction.	0.014158585	2012	OPRM1	6	154039662	A	G
rs1799971	16046395	4988	OPRM1	umls:C0038580	BeFree	Genetic variants of OPRM1 have been implicated in predisposition to drug addiction, in particular the single nucleotide polymorphism A118G, leading to an N40D substitution, with an allele frequency of 10-32%, and uncertain functions.	0.014158585	2005	OPRM1	6	154039662	A	G
rs1799971	11424981	4988	OPRM1	umls:C0038580	BeFree	Nonreplication of association between mu-opioid-receptor gene (OPRM1) A118G polymorphism and substance dependence.	0.014158585	2001	OPRM1	6	154039662	A	G
rs1799971	19528658	4988	OPRM1	umls:C0038580	BeFree	A single nucleotide polymorphism (SNP) in the human mu-opioid receptor gene (OPRM1 A118G) has been widely studied for its association in a variety of drug addiction and pain sensitivity phenotypes; however, the extent of these adaptations and the mechanisms underlying these associations remain elusive.	0.014158585	2009	OPRM1	6	154039662	A	G
rs1799971	20074870	4988	OPRM1	umls:C0038580	BeFree	A common single nucleotide polymorphism (SNP), A118G, in the mu-opioid receptor gene can affect opioid function and, consequently, has been suggested to contribute to individual variability in pain management and drug addiction.	0.014158585	2010	OPRM1	6	154039662	A	G
rs1800497	25500252	1813	DRD2	umls:C0038580	BeFree	Growing evidence indicated conflicting results about the dopamine receptor D2 (DRD2)/kinase domain containing 1 gene (ANKK1) TaqIA single nucleotide polymorphism (rs1800497) and common illicit drug dependence risk including stimulants, opioid and marijuana.	0.00434307	2014	ANKK1	11	113400106	G	A
rs1800955	16167465	1815	DRD4	umls:C0038580	BeFree	Association between the -521 C/T SNP of the DRD4 promoter region and substance dependence was significant in the subgroup of heroin dependents (p = 0.044).	0.000814326	2005	DRD4	11	636784	T	C
rs279858	18482426	2555	GABRA2	umls:C0038580	BeFree	These included a synonymous polymorphism in GABRA2 (rs279858), lying in a highly conserved region, which has been shown previously to be associated with alcohol and drug dependence.	0.001628651	2008	GABRA2	4	46312576	T	C
rs324420	16972078	2166	FAAH	umls:C0038580	BeFree	The fatty acid amide hydrolase 385 A/A (P129T) variant: haplotype analysis of an ancient missense mutation and validation of risk for drug addiction.	0.001085767	2006	FAAH	1	46405089	C	A
rs324420	24407958	2166	FAAH	umls:C0038580	BeFree	As conclusion, because drug addiction is a multi-step process and a preventable disease, our results indicate that the FAAH C385A SNP is one of the most promising candidates for individuals who are at higher risk for alcohol problems.	0.001085767	2013	FAAH	1	46405089	C	A

GWASdb Annotation(Total Genotypes:0)
(Waiting for update.)

GWASdb Snp Trait(Total Genotypes:157)
CHR	POS	SNPID	REF	ALT	ORI_SNPID	PMID	P_VALUE	P_VALUE_TEXT	OR/BETA	CI95_TEXT	GWAS_INITIAL_SAMPLE_SIZE	SUB_POPULATION	SUPER_POPULATION	GWAS_TRAIT	HPO_ID	HPO_TERM	DO_ID	DO_TERM	MESH_ID	MESH_TERM	EFO_ID	EFO_TERM	DOLITE_TERM	RISK_ALLELE	PUBLICATION_TYPE	AA	GENE_SYMBOL	TYPE	REFGENE
1	2944527	rs2142569	G	A	rs2142569	24832863	4.00E-06	NA	NA	NA	up to 2,322 European ancestry individuals from 118 families	European(2322)	ALL(2322)	EUR(2322)	ALL(2322)	Substance dependence phenotypes	HPOID:0001939	Abnormality of metabolism/homeostasis	DOID:9973	substance dependence	NA	NA	NA	NA	Drug abuse	NA	Research Support, N.I.H., Extramural	C	NA
1	14673385	rs12121975	G	T	rs12121975	21818250	7.25E-04	Illegal drug dependence	NA	NA	1171 European ancestry dependent cases; 1395 European ancestry controls; 652 African American ancestry cases; 499 African American ancestry controls	African American(1151)	European(2566)	ALL(3717)	AFR(1151)	EUR(2566)	ALL(3717)	Substance dependence	HPOID:0000707	Abnormality of the nervous system	DOID:9973	substance dependence	NA	NA	NA	NA	Drug abuse	NA	Research Support, N.I.H., Extramural
1	55525400	rs483462	G	A	rs483462	21818250	7.99E-04	Alcohol dependence	NA	NA	1171 European ancestry dependent cases; 1395 European ancestry controls; 652 African American ancestry cases; 499 African American ancestry controls	African American(1151)	European(2566)	ALL(3717)	AFR(1151)	EUR(2566)	ALL(3717)	Substance dependence	HPOID:0000707	Abnormality of the nervous system	DOID:9973	substance dependence	NA	NA	NA	NA	Drug abuse	NA	Research Support, N.I.H., Extramural
1	55546895	rs683880	T	C	rs683880	21818250	5.67E-04	Alcohol dependence	NA	NA	1171 European ancestry dependent cases; 1395 European ancestry controls; 652 African American ancestry cases; 499 African American ancestry controls	African American(1151)	European(2566)	ALL(3717)	AFR(1151)	EUR(2566)	ALL(3717)	Substance dependence	HPOID:0000707	Abnormality of the nervous system	DOID:9973	substance dependence	NA	NA	NA	NA	Drug abuse	NA	Research Support, N.I.H., Extramural
1	105735780	rs11184469	A	G	rs11184469	21818250	4.31E-05	Illegal drug dependence	NA	NA	1171 European ancestry dependent cases; 1395 European ancestry controls; 652 African American ancestry cases; 499 African American ancestry controls	African American(1151)	European(2566)	ALL(3717)	AFR(1151)	EUR(2566)	ALL(3717)	Substance dependence	HPOID:0000707	Abnormality of the nervous system	DOID:9973	substance dependence	NA	NA	NA	NA	Drug abuse	NA	Research Support, N.I.H., Extramural
1	108588372	rs12569350	G	A	rs12569350	21818250	7.82E-04	Illegal drug dependence	NA	NA	1171 European ancestry dependent cases; 1395 European ancestry controls; 652 African American ancestry cases; 499 African American ancestry controls	African American(1151)	European(2566)	ALL(3717)	AFR(1151)	EUR(2566)	ALL(3717)	Substance dependence	HPOID:0000707	Abnormality of the nervous system	DOID:9973	substance dependence	NA	NA	NA	NA	Drug abuse	NA	Research Support, N.I.H., Extramural
1	108596968	rs1777454	T	G	rs1777454	21818250	8.55E-04	Alcohol dependence	NA	NA	1171 European ancestry dependent cases; 1395 European ancestry controls; 652 African American ancestry cases; 499 African American ancestry controls	African American(1151)	European(2566)	ALL(3717)	AFR(1151)	EUR(2566)	ALL(3717)	Substance dependence	HPOID:0000707	Abnormality of the nervous system	DOID:9973	substance dependence	NA	NA	NA	NA	Drug abuse	NA	Research Support, N.I.H., Extramural
1	166631034	rs577317	A	G	rs577317	21818250	2.28E-04	Illegal drug dependence	NA	NA	1171 European ancestry dependent cases; 1395 European ancestry controls; 652 African American ancestry cases; 499 African American ancestry controls	African American(1151)	European(2566)	ALL(3717)	AFR(1151)	EUR(2566)	ALL(3717)	Substance dependence	HPOID:0000707	Abnormality of the nervous system	DOID:9973	substance dependence	NA	NA	NA	NA	Drug abuse	NA	Research Support, N.I.H., Extramural
1	172360164	rs2227198	A	G	rs2227198	21818250	2.21E-04	Alcohol dependence	NA	NA	1171 European ancestry dependent cases; 1395 European ancestry controls; 652 African American ancestry cases; 499 African American ancestry controls	African American(1151)	European(2566)	ALL(3717)	AFR(1151)	EUR(2566)	ALL(3717)	Substance dependence	HPOID:0000707	Abnormality of the nervous system	DOID:9973	substance dependence	NA	NA	NA	NA	Drug abuse	NA	Research Support, N.I.H., Extramural
1	183812807	rs11806497	G	A,C,T	rs11806497	21818250	5.41E-04	Illegal drug dependence	NA	NA	1171 European ancestry dependent cases; 1395 European ancestry controls; 652 African American ancestry cases; 499 African American ancestry controls	African American(1151)	European(2566)	ALL(3717)	AFR(1151)	EUR(2566)	ALL(3717)	Substance dependence	HPOID:0000707	Abnormality of the nervous system	DOID:9973	substance dependence	NA	NA	NA	NA	Drug abuse	NA	Research Support, N.I.H., Extramural
1	192902415	rs842796	T	C	rs842796	24832863	2.24E-06	NA	NA	NA	up to 2,322 European ancestry individuals from 118 families	European(2322)	ALL(2322)	EUR(2322)	ALL(2322)	Substance dependence phenotypes	HPOID:0001939	Abnormality of metabolism/homeostasis	DOID:9973	substance dependence	NA	NA	NA	NA	Drug abuse	NA	Research Support, N.I.H., Extramural	G	NA
1	201121523	rs6694122	T	C	rs6694122	21818250	2.04E-04	Alcohol dependence	NA	NA	1171 European ancestry dependent cases; 1395 European ancestry controls; 652 African American ancestry cases; 499 African American ancestry controls	African American(1151)	European(2566)	ALL(3717)	AFR(1151)	EUR(2566)	ALL(3717)	Substance dependence	HPOID:0000707	Abnormality of the nervous system	DOID:9973	substance dependence	NA	NA	NA	NA	Drug abuse	NA	Research Support, N.I.H., Extramural
1	234427534	rs594349	A	C	rs594349	24832863	3.55E-06	NA	NA	NA	up to 2,322 European ancestry individuals from 118 families	European(2322)	ALL(2322)	EUR(2322)	ALL(2322)	Substance dependence phenotypes	HPOID:0001939	Abnormality of metabolism/homeostasis	DOID:9973	substance dependence	NA	NA	NA	NA	Drug abuse	NA	Research Support, N.I.H., Extramural	G	SLC35F3
1	246005798	rs9728248	C	A	rs9728248	21818250	1.84E-04	Alcohol dependence	NA	NA	1171 European ancestry dependent cases; 1395 European ancestry controls; 652 African American ancestry cases; 499 African American ancestry controls	African American(1151)	European(2566)	ALL(3717)	AFR(1151)	EUR(2566)	ALL(3717)	Substance dependence	HPOID:0000707	Abnormality of the nervous system	DOID:9973	substance dependence	NA	NA	NA	NA	Drug abuse	NA	Research Support, N.I.H., Extramural
2	38414541	rs183487	T	C	rs183487	21818250	6.45E-04	Alcohol dependence	NA	NA	1171 European ancestry dependent cases; 1395 European ancestry controls; 652 African American ancestry cases; 499 African American ancestry controls	African American(1151)	European(2566)	ALL(3717)	AFR(1151)	EUR(2566)	ALL(3717)	Substance dependence	HPOID:0000707	Abnormality of the nervous system	DOID:9973	substance dependence	NA	NA	NA	NA	Drug abuse	NA	Research Support, N.I.H., Extramural
2	43146800	rs1078100	T	C	rs1078100	21818250	2.23E-04	Illegal drug dependence	NA	NA	1171 European ancestry dependent cases; 1395 European ancestry controls; 652 African American ancestry cases; 499 African American ancestry controls	African American(1151)	European(2566)	ALL(3717)	AFR(1151)	EUR(2566)	ALL(3717)	Substance dependence	HPOID:0000707	Abnormality of the nervous system	DOID:9973	substance dependence	NA	NA	NA	NA	Drug abuse	NA	Research Support, N.I.H., Extramural
2	129990869	rs13033217	T	C	rs13033217	24832863	5.38E-04	NA	NA	NA	up to 2,322 European ancestry individuals from 118 families	European(2322)	ALL(2322)	EUR(2322)	ALL(2322)	Substance dependence phenotypes	HPOID:0001939	Abnormality of metabolism/homeostasis	DOID:9973	substance dependence	NA	NA	NA	NA	Drug abuse	NA	Research Support, N.I.H., Extramural	T	NA
2	129990869	rs13033217	T	C	rs13033217	24832863	7.18E-06	NA	NA	NA	up to 2,322 European ancestry individuals from 118 families	European(2322)	ALL(2322)	EUR(2322)	ALL(2322)	Substance dependence phenotypes	HPOID:0001939	Abnormality of metabolism/homeostasis	DOID:9973	substance dependence	NA	NA	NA	NA	Drug abuse	NA	Research Support, N.I.H., Extramural	T	NA
2	129998443	rs2952621	T	C	rs2952621	24832863	1.77E-08	NA	NA	NA	up to 2,322 European ancestry individuals from 118 families	European(2322)	ALL(2322)	EUR(2322)	ALL(2322)	Substance dependence phenotypes	HPOID:0001939	Abnormality of metabolism/homeostasis	DOID:9973	substance dependence	NA	NA	NA	NA	Drug abuse	NA	Research Support, N.I.H., Extramural	C	NA
2	129998443	rs2952621	T	C	rs2952621	24832863	3.85E-05	NA	NA	NA	up to 2,322 European ancestry individuals from 118 families	European(2322)	ALL(2322)	EUR(2322)	ALL(2322)	Substance dependence phenotypes	HPOID:0001939	Abnormality of metabolism/homeostasis	DOID:9973	substance dependence	NA	NA	NA	NA	Drug abuse	NA	Research Support, N.I.H., Extramural	C	NA
2	130007750	rs2197022	G	T	rs2197022	24832863	1.97E-04	NA	NA	NA	up to 2,322 European ancestry individuals from 118 families	European(2322)	ALL(2322)	EUR(2322)	ALL(2322)	Substance dependence phenotypes	HPOID:0001939	Abnormality of metabolism/homeostasis	DOID:9973	substance dependence	NA	NA	NA	NA	Drug abuse	NA	Research Support, N.I.H., Extramural	G	NA
2	130007750	rs2197022	G	T	rs2197022	24832863	2.53E-06	NA	NA	NA	up to 2,322 European ancestry individuals from 118 families	European(2322)	ALL(2322)	EUR(2322)	ALL(2322)	Substance dependence phenotypes	HPOID:0001939	Abnormality of metabolism/homeostasis	DOID:9973	substance dependence	NA	NA	NA	NA	Drug abuse	NA	Research Support, N.I.H., Extramural	G	NA
2	130034326	rs7567687	C	T	rs7567687	24832863	8.64E-06	NA	NA	NA	up to 2,322 European ancestry individuals from 118 families	European(2322)	ALL(2322)	EUR(2322)	ALL(2322)	Substance dependence phenotypes	HPOID:0001939	Abnormality of metabolism/homeostasis	DOID:9973	substance dependence	NA	NA	NA	NA	Drug abuse	NA	Research Support, N.I.H., Extramural	C	NA
2	145813161	rs955944	A	C	rs955944	21818250	2.84E-04	Illegal drug dependence	NA	NA	1171 European ancestry dependent cases; 1395 European ancestry controls; 652 African American ancestry cases; 499 African American ancestry controls	African American(1151)	European(2566)	ALL(3717)	AFR(1151)	EUR(2566)	ALL(3717)	Substance dependence	HPOID:0000707	Abnormality of the nervous system	DOID:9973	substance dependence	NA	NA	NA	NA	Drug abuse	NA	Research Support, N.I.H., Extramural
2	149990087	rs6737636	C	T	rs6737636	21818250	1.74E-04	Alcohol dependence	NA	NA	1171 European ancestry dependent cases; 1395 European ancestry controls; 652 African American ancestry cases; 499 African American ancestry controls	African American(1151)	European(2566)	ALL(3717)	AFR(1151)	EUR(2566)	ALL(3717)	Substance dependence	HPOID:0000707	Abnormality of the nervous system	DOID:9973	substance dependence	NA	NA	NA	NA	Drug abuse	NA	Research Support, N.I.H., Extramural
2	151871888	rs4664875	T	C	rs4664875	21818250	4.06E-04	Illegal drug dependence	NA	NA	1171 European ancestry dependent cases; 1395 European ancestry controls; 652 African American ancestry cases; 499 African American ancestry controls	African American(1151)	European(2566)	ALL(3717)	AFR(1151)	EUR(2566)	ALL(3717)	Substance dependence	HPOID:0000707	Abnormality of the nervous system	DOID:9973	substance dependence	NA	NA	NA	NA	Drug abuse	NA	Research Support, N.I.H., Extramural
2	153872845	rs1347395	A	G	rs1347395	21818250	1.82E-04	Alcohol dependence	NA	NA	1171 European ancestry dependent cases; 1395 European ancestry controls; 652 African American ancestry cases; 499 African American ancestry controls	African American(1151)	European(2566)	ALL(3717)	AFR(1151)	EUR(2566)	ALL(3717)	Substance dependence	HPOID:0000707	Abnormality of the nervous system	DOID:9973	substance dependence	NA	NA	NA	NA	Drug abuse	NA	Research Support, N.I.H., Extramural
2	166440547	rs10803799	A	C	rs10803799	21818250	1.16E-04	Alcohol dependence	NA	NA	1171 European ancestry dependent cases; 1395 European ancestry controls; 652 African American ancestry cases; 499 African American ancestry controls	African American(1151)	European(2566)	ALL(3717)	AFR(1151)	EUR(2566)	ALL(3717)	Substance dependence	HPOID:0000707	Abnormality of the nervous system	DOID:9973	substance dependence	NA	NA	NA	NA	Drug abuse	NA	Research Support, N.I.H., Extramural
2	239348995	rs579861	G	T	rs579861	21818250	5.73E-04	Illegal drug dependence	NA	NA	1171 European ancestry dependent cases; 1395 European ancestry controls; 652 African American ancestry cases; 499 African American ancestry controls	African American(1151)	European(2566)	ALL(3717)	AFR(1151)	EUR(2566)	ALL(3717)	Substance dependence	HPOID:0000707	Abnormality of the nervous system	DOID:9973	substance dependence	NA	NA	NA	NA	Drug abuse	NA	Research Support, N.I.H., Extramural
3	10966588	rs4684746	A	G	rs4684746	21818250	1.94E-04	Alcohol dependence	NA	NA	1171 European ancestry dependent cases; 1395 European ancestry controls; 652 African American ancestry cases; 499 African American ancestry controls	African American(1151)	European(2566)	ALL(3717)	AFR(1151)	EUR(2566)	ALL(3717)	Substance dependence	HPOID:0000707	Abnormality of the nervous system	DOID:9973	substance dependence	NA	NA	NA	NA	Drug abuse	NA	Research Support, N.I.H., Extramural
3	15295364	rs1318937	A	G	rs1318937	21818250	1.44E-04	Alcohol dependence	NA	NA	1171 European ancestry dependent cases; 1395 European ancestry controls; 652 African American ancestry cases; 499 African American ancestry controls	African American(1151)	European(2566)	ALL(3717)	AFR(1151)	EUR(2566)	ALL(3717)	Substance dependence	HPOID:0000707	Abnormality of the nervous system	DOID:9973	substance dependence	NA	NA	NA	NA	Drug abuse	NA	Research Support, N.I.H., Extramural
3	16670655	rs17200411	C	T	rs17200411	21818250	2.44E-04	Illegal drug dependence	NA	NA	1171 European ancestry dependent cases; 1395 European ancestry controls; 652 African American ancestry cases; 499 African American ancestry controls	African American(1151)	European(2566)	ALL(3717)	AFR(1151)	EUR(2566)	ALL(3717)	Substance dependence	HPOID:0000707	Abnormality of the nervous system	DOID:9973	substance dependence	NA	NA	NA	NA	Drug abuse	NA	Research Support, N.I.H., Extramural
3	23185162	rs13317243	G	C	rs13317243	21818250	5.25E-04	Illegal drug dependence	NA	NA	1171 European ancestry dependent cases; 1395 European ancestry controls; 652 African American ancestry cases; 499 African American ancestry controls	African American(1151)	European(2566)	ALL(3717)	AFR(1151)	EUR(2566)	ALL(3717)	Substance dependence	HPOID:0000707	Abnormality of the nervous system	DOID:9973	substance dependence	NA	NA	NA	NA	Drug abuse	NA	Research Support, N.I.H., Extramural
3	23192695	rs4858060	T	C	rs4858060	21818250	5.85E-04	Alcohol dependence	NA	NA	1171 European ancestry dependent cases; 1395 European ancestry controls; 652 African American ancestry cases; 499 African American ancestry controls	African American(1151)	European(2566)	ALL(3717)	AFR(1151)	EUR(2566)	ALL(3717)	Substance dependence	HPOID:0000707	Abnormality of the nervous system	DOID:9973	substance dependence	NA	NA	NA	NA	Drug abuse	NA	Research Support, N.I.H., Extramural
3	41485477	rs1495692	T	C	rs1495692	21818250	4.32E-05	Alcohol dependence	NA	NA	1171 European ancestry dependent cases; 1395 European ancestry controls; 652 African American ancestry cases; 499 African American ancestry controls	African American(1151)	European(2566)	ALL(3717)	AFR(1151)	EUR(2566)	ALL(3717)	Substance dependence	HPOID:0000707	Abnormality of the nervous system	DOID:9973	substance dependence	NA	NA	NA	NA	Drug abuse	NA	Research Support, N.I.H., Extramural
3	62263047	rs2291540	T	C	rs2291540	24832863	5.01E-06	NA	NA	NA	up to 2,322 European ancestry individuals from 118 families	European(2322)	ALL(2322)	EUR(2322)	ALL(2322)	Substance dependence phenotypes	HPOID:0001939	Abnormality of metabolism/homeostasis	DOID:9973	substance dependence	NA	NA	NA	NA	Drug abuse	NA	Research Support, N.I.H., Extramural	A	PTPRG
3	139784874	rs2350488	A	G	rs2350488	21818250	2.20E-04	Illegal drug dependence	NA	NA	1171 European ancestry dependent cases; 1395 European ancestry controls; 652 African American ancestry cases; 499 African American ancestry controls	African American(1151)	European(2566)	ALL(3717)	AFR(1151)	EUR(2566)	ALL(3717)	Substance dependence	HPOID:0000707	Abnormality of the nervous system	DOID:9973	substance dependence	NA	NA	NA	NA	Drug abuse	NA	Research Support, N.I.H., Extramural
3	142913697	rs6786129	A	G	rs6786129	21818250	6.79E-04	Illegal drug dependence	NA	NA	1171 European ancestry dependent cases; 1395 European ancestry controls; 652 African American ancestry cases; 499 African American ancestry controls	African American(1151)	European(2566)	ALL(3717)	AFR(1151)	EUR(2566)	ALL(3717)	Substance dependence	HPOID:0000707	Abnormality of the nervous system	DOID:9973	substance dependence	NA	NA	NA	NA	Drug abuse	NA	Research Support, N.I.H., Extramural
3	143090003	rs7619769	A	G	rs7619769	24832863	4.47E-04	NA	NA	NA	up to 2,322 European ancestry individuals from 118 families	European(2322)	ALL(2322)	EUR(2322)	ALL(2322)	Substance dependence phenotypes	HPOID:0001939	Abnormality of metabolism/homeostasis	DOID:9973	substance dependence	NA	NA	NA	NA	Drug abuse	NA	Research Support, N.I.H., Extramural	G	SLC9A9
3	143090003	rs7619769	A	G	rs7619769	24832863	4.78E-06	NA	NA	NA	up to 2,322 European ancestry individuals from 118 families	European(2322)	ALL(2322)	EUR(2322)	ALL(2322)	Substance dependence phenotypes	HPOID:0001939	Abnormality of metabolism/homeostasis	DOID:9973	substance dependence	NA	NA	NA	NA	Drug abuse	NA	Research Support, N.I.H., Extramural	G	SLC9A9
3	143090698	rs11715693	C	T	rs11715693	24832863	8.79E-06	NA	NA	NA	up to 2,322 European ancestry individuals from 118 families	European(2322)	ALL(2322)	EUR(2322)	ALL(2322)	Substance dependence phenotypes	HPOID:0001939	Abnormality of metabolism/homeostasis	DOID:9973	substance dependence	NA	NA	NA	NA	Drug abuse	NA	Research Support, N.I.H., Extramural	T	SLC9A9
3	164558595	rs9847462	A	G	rs9847462	24832863	2.64E-06	NA	NA	NA	up to 2,322 European ancestry individuals from 118 families	European(2322)	ALL(2322)	EUR(2322)	ALL(2322)	Substance dependence phenotypes	HPOID:0001939	Abnormality of metabolism/homeostasis	DOID:9973	substance dependence	NA	NA	NA	NA	Drug abuse	NA	Research Support, N.I.H., Extramural	A	NA
3	164558595	rs9847462	A	G	rs9847462	24832863	8.38E-05	NA	NA	NA	up to 2,322 European ancestry individuals from 118 families	European(2322)	ALL(2322)	EUR(2322)	ALL(2322)	Substance dependence phenotypes	HPOID:0001939	Abnormality of metabolism/homeostasis	DOID:9973	substance dependence	NA	NA	NA	NA	Drug abuse	NA	Research Support, N.I.H., Extramural	A	NA
3	181277708	rs16832544	G	A	rs16832544	21818250	3.43E-04	Illegal drug dependence	NA	NA	1171 European ancestry dependent cases; 1395 European ancestry controls; 652 African American ancestry cases; 499 African American ancestry controls	African American(1151)	European(2566)	ALL(3717)	AFR(1151)	EUR(2566)	ALL(3717)	Substance dependence	HPOID:0000707	Abnormality of the nervous system	DOID:9973	substance dependence	NA	NA	NA	NA	Drug abuse	NA	Research Support, N.I.H., Extramural
4	28660856	rs9996729	T	C	rs9996729	21818250	6.80E-05	Illegal drug dependence	NA	NA	1171 European ancestry dependent cases; 1395 European ancestry controls; 652 African American ancestry cases; 499 African American ancestry controls	African American(1151)	European(2566)	ALL(3717)	AFR(1151)	EUR(2566)	ALL(3717)	Substance dependence	HPOID:0000707	Abnormality of the nervous system	DOID:9973	substance dependence	NA	NA	NA	NA	Drug abuse	NA	Research Support, N.I.H., Extramural
4	37075996	rs10484210	A	G	rs10484210	21818250	6.23E-05	Alcohol dependence	NA	NA	1171 European ancestry dependent cases; 1395 European ancestry controls; 652 African American ancestry cases; 499 African American ancestry controls	African American(1151)	European(2566)	ALL(3717)	AFR(1151)	EUR(2566)	ALL(3717)	Substance dependence	HPOID:0000707	Abnormality of the nervous system	DOID:9973	substance dependence	NA	NA	NA	NA	Drug abuse	NA	Research Support, N.I.H., Extramural
4	40503270	rs17587144	G	A	rs17587144	21818250	6.65E-05	Illegal drug dependence	NA	NA	1171 European ancestry dependent cases; 1395 European ancestry controls; 652 African American ancestry cases; 499 African American ancestry controls	African American(1151)	European(2566)	ALL(3717)	AFR(1151)	EUR(2566)	ALL(3717)	Substance dependence	HPOID:0000707	Abnormality of the nervous system	DOID:9973	substance dependence	NA	NA	NA	NA	Drug abuse	NA	Research Support, N.I.H., Extramural
4	42845169	rs6447192	T	C	rs6447192	21818250	7.44E-04	Alcohol dependence	NA	NA	1171 European ancestry dependent cases; 1395 European ancestry controls; 652 African American ancestry cases; 499 African American ancestry controls	African American(1151)	European(2566)	ALL(3717)	AFR(1151)	EUR(2566)	ALL(3717)	Substance dependence	HPOID:0000707	Abnormality of the nervous system	DOID:9973	substance dependence	NA	NA	NA	NA	Drug abuse	NA	Research Support, N.I.H., Extramural
4	65654988	rs11731709	A	G	rs11731709	21818250	3.30E-04	Illegal drug dependence	NA	NA	1171 European ancestry dependent cases; 1395 European ancestry controls; 652 African American ancestry cases; 499 African American ancestry controls	African American(1151)	European(2566)	ALL(3717)	AFR(1151)	EUR(2566)	ALL(3717)	Substance dependence	HPOID:0000707	Abnormality of the nervous system	DOID:9973	substance dependence	NA	NA	NA	NA	Drug abuse	NA	Research Support, N.I.H., Extramural
4	73863809	rs10518112	C	G	rs10518112	21818250	5.31E-04	Illegal drug dependence	NA	NA	1171 European ancestry dependent cases; 1395 European ancestry controls; 652 African American ancestry cases; 499 African American ancestry controls	African American(1151)	European(2566)	ALL(3717)	AFR(1151)	EUR(2566)	ALL(3717)	Substance dependence	HPOID:0000707	Abnormality of the nervous system	DOID:9973	substance dependence	NA	NA	NA	NA	Drug abuse	NA	Research Support, N.I.H., Extramural
4	81068101	rs13129263	G	A	rs13129263	24832863	9.21E-06	NA	NA	NA	up to 2,322 European ancestry individuals from 118 families	European(2322)	ALL(2322)	EUR(2322)	ALL(2322)	Substance dependence phenotypes	HPOID:0001939	Abnormality of metabolism/homeostasis	DOID:9973	substance dependence	NA	NA	NA	NA	Drug abuse	NA	Research Support, N.I.H., Extramural	G	NA
4	81087073	rs13138779	G	A	rs13138779	24832863	7.99E-06	NA	NA	NA	up to 2,322 European ancestry individuals from 118 families	European(2322)	ALL(2322)	EUR(2322)	ALL(2322)	Substance dependence phenotypes	HPOID:0001939	Abnormality of metabolism/homeostasis	DOID:9973	substance dependence	NA	NA	NA	NA	Drug abuse	NA	Research Support, N.I.H., Extramural	G	NA
4	93467802	rs17319672	C	T	rs17319672	21818250	8.72E-06	Illegal drug dependence	NA	NA	1171 European ancestry dependent cases; 1395 European ancestry controls; 652 African American ancestry cases; 499 African American ancestry controls	African American(1151)	European(2566)	ALL(3717)	AFR(1151)	EUR(2566)	ALL(3717)	Substance dependence	HPOID:0000707	Abnormality of the nervous system	DOID:9973	substance dependence	NA	NA	NA	NA	Drug abuse	NA	Research Support, N.I.H., Extramural
4	93489287	rs7682842	G	A	rs7682842	21818250	5.98E-04	Alcohol dependence	NA	NA	1171 European ancestry dependent cases; 1395 European ancestry controls; 652 African American ancestry cases; 499 African American ancestry controls	African American(1151)	European(2566)	ALL(3717)	AFR(1151)	EUR(2566)	ALL(3717)	Substance dependence	HPOID:0000707	Abnormality of the nervous system	DOID:9973	substance dependence	NA	NA	NA	NA	Drug abuse	NA	Research Support, N.I.H., Extramural
4	95558854	rs11724023	T	C	rs11724023	21818250	3.68E-04	Alcohol dependence	NA	NA	1171 European ancestry dependent cases; 1395 European ancestry controls; 652 African American ancestry cases; 499 African American ancestry controls	African American(1151)	European(2566)	ALL(3717)	AFR(1151)	EUR(2566)	ALL(3717)	Substance dependence	HPOID:0000707	Abnormality of the nervous system	DOID:9973	substance dependence	NA	NA	NA	NA	Drug abuse	NA	Research Support, N.I.H., Extramural
4	178317692	rs1506807	A	G	rs1506807	24832863	4.43E-07	NA	NA	NA	up to 2,322 European ancestry individuals from 118 families	European(2322)	ALL(2322)	EUR(2322)	ALL(2322)	Substance dependence phenotypes	HPOID:0001939	Abnormality of metabolism/homeostasis	DOID:9973	substance dependence	NA	NA	NA	NA	Drug abuse	NA	Research Support, N.I.H., Extramural	A	NA
4	178317692	rs1506807	A	G	rs1506807	24832863	9.12E-04	NA	NA	NA	up to 2,322 European ancestry individuals from 118 families	European(2322)	ALL(2322)	EUR(2322)	ALL(2322)	Substance dependence phenotypes	HPOID:0001939	Abnormality of metabolism/homeostasis	DOID:9973	substance dependence	NA	NA	NA	NA	Drug abuse	NA	Research Support, N.I.H., Extramural	A	NA
4	185323726	rs724528	G	A	rs724528	21818250	8.75E-04	Alcohol dependence	NA	NA	1171 European ancestry dependent cases; 1395 European ancestry controls; 652 African American ancestry cases; 499 African American ancestry controls	African American(1151)	European(2566)	ALL(3717)	AFR(1151)	EUR(2566)	ALL(3717)	Substance dependence	HPOID:0000707	Abnormality of the nervous system	DOID:9973	substance dependence	NA	NA	NA	NA	Drug abuse	NA	Research Support, N.I.H., Extramural
5	38046170	rs380930	T	C	rs380930	21818250	2.79E-04	Illegal drug dependence	NA	NA	1171 European ancestry dependent cases; 1395 European ancestry controls; 652 African American ancestry cases; 499 African American ancestry controls	African American(1151)	European(2566)	ALL(3717)	AFR(1151)	EUR(2566)	ALL(3717)	Substance dependence	HPOID:0000707	Abnormality of the nervous system	DOID:9973	substance dependence	NA	NA	NA	NA	Drug abuse	NA	Research Support, N.I.H., Extramural
5	57822482	rs4700297	A	T	rs4700297	21818250	5.04E-04	Illegal drug dependence	NA	NA	1171 European ancestry dependent cases; 1395 European ancestry controls; 652 African American ancestry cases; 499 African American ancestry controls	African American(1151)	European(2566)	ALL(3717)	AFR(1151)	EUR(2566)	ALL(3717)	Substance dependence	HPOID:0000707	Abnormality of the nervous system	DOID:9973	substance dependence	NA	NA	NA	NA	Drug abuse	NA	Research Support, N.I.H., Extramural
5	167449057	rs17069636	T	A	rs17069636	21818250	2.93E-04	Illegal drug dependence	NA	NA	1171 European ancestry dependent cases; 1395 European ancestry controls; 652 African American ancestry cases; 499 African American ancestry controls	African American(1151)	European(2566)	ALL(3717)	AFR(1151)	EUR(2566)	ALL(3717)	Substance dependence	HPOID:0000707	Abnormality of the nervous system	DOID:9973	substance dependence	NA	NA	NA	NA	Drug abuse	NA	Research Support, N.I.H., Extramural
5	169843630	rs13175143	C	T	rs13175143	21818250	7.58E-04	Alcohol dependence	NA	NA	1171 European ancestry dependent cases; 1395 European ancestry controls; 652 African American ancestry cases; 499 African American ancestry controls	African American(1151)	European(2566)	ALL(3717)	AFR(1151)	EUR(2566)	ALL(3717)	Substance dependence	HPOID:0000707	Abnormality of the nervous system	DOID:9973	substance dependence	NA	NA	NA	NA	Drug abuse	NA	Research Support, N.I.H., Extramural
6	22202679	rs7749084	T	C	rs7749084	21818250	8.92E-04	Alcohol dependence	NA	NA	1171 European ancestry dependent cases; 1395 European ancestry controls; 652 African American ancestry cases; 499 African American ancestry controls	African American(1151)	European(2566)	ALL(3717)	AFR(1151)	EUR(2566)	ALL(3717)	Substance dependence	HPOID:0000707	Abnormality of the nervous system	DOID:9973	substance dependence	NA	NA	NA	NA	Drug abuse	NA	Research Support, N.I.H., Extramural
6	22755579	rs12154136	G	A	rs12154136	21818250	9.06E-05	Illegal drug dependence	NA	NA	1171 European ancestry dependent cases; 1395 European ancestry controls; 652 African American ancestry cases; 499 African American ancestry controls	African American(1151)	European(2566)	ALL(3717)	AFR(1151)	EUR(2566)	ALL(3717)	Substance dependence	HPOID:0000707	Abnormality of the nervous system	DOID:9973	substance dependence	NA	NA	NA	NA	Drug abuse	NA	Research Support, N.I.H., Extramural
6	32180120	rs2269418	T	G	rs2269418	21818250	4.43E-04	Illegal drug dependence	NA	NA	1171 European ancestry dependent cases; 1395 European ancestry controls; 652 African American ancestry cases; 499 African American ancestry controls	African American(1151)	European(2566)	ALL(3717)	AFR(1151)	EUR(2566)	ALL(3717)	Substance dependence	HPOID:0000707	Abnormality of the nervous system	DOID:9973	substance dependence	NA	NA	NA	NA	Drug abuse	NA	Research Support, N.I.H., Extramural
6	45924967	rs4714892	A	G	rs4714892	21818250	5.78E-04	Alcohol dependence	NA	NA	1171 European ancestry dependent cases; 1395 European ancestry controls; 652 African American ancestry cases; 499 African American ancestry controls	African American(1151)	European(2566)	ALL(3717)	AFR(1151)	EUR(2566)	ALL(3717)	Substance dependence	HPOID:0000707	Abnormality of the nervous system	DOID:9973	substance dependence	NA	NA	NA	NA	Drug abuse	NA	Research Support, N.I.H., Extramural
6	92965297	rs1822589	T	C	rs1822589	21818250	7.90E-04	Alcohol dependence	NA	NA	1171 European ancestry dependent cases; 1395 European ancestry controls; 652 African American ancestry cases; 499 African American ancestry controls	African American(1151)	European(2566)	ALL(3717)	AFR(1151)	EUR(2566)	ALL(3717)	Substance dependence	HPOID:0000707	Abnormality of the nervous system	DOID:9973	substance dependence	NA	NA	NA	NA	Drug abuse	NA	Research Support, N.I.H., Extramural
6	92999553	rs1020320	T	C	rs1020320	21818250	7.00E-04	Illegal drug dependence	NA	NA	1171 European ancestry dependent cases; 1395 European ancestry controls; 652 African American ancestry cases; 499 African American ancestry controls	African American(1151)	European(2566)	ALL(3717)	AFR(1151)	EUR(2566)	ALL(3717)	Substance dependence	HPOID:0000707	Abnormality of the nervous system	DOID:9973	substance dependence	NA	NA	NA	NA	Drug abuse	NA	Research Support, N.I.H., Extramural
6	129793717	rs6569603	C	A	rs6569603	21818250	1.91E-04	Alcohol dependence	NA	NA	1171 European ancestry dependent cases; 1395 European ancestry controls; 652 African American ancestry cases; 499 African American ancestry controls	African American(1151)	European(2566)	ALL(3717)	AFR(1151)	EUR(2566)	ALL(3717)	Substance dependence	HPOID:0000707	Abnormality of the nervous system	DOID:9973	substance dependence	NA	NA	NA	NA	Drug abuse	NA	Research Support, N.I.H., Extramural
6	152738345	rs214989	A	G	rs214989	21818250	2.46E-04	Alcohol dependence	NA	NA	1171 European ancestry dependent cases; 1395 European ancestry controls; 652 African American ancestry cases; 499 African American ancestry controls	African American(1151)	European(2566)	ALL(3717)	AFR(1151)	EUR(2566)	ALL(3717)	Substance dependence	HPOID:0000707	Abnormality of the nervous system	DOID:9973	substance dependence	NA	NA	NA	NA	Drug abuse	NA	Research Support, N.I.H., Extramural
6	155759778	rs9322524	T	C	rs9322524	24832863	5.84E-06	NA	NA	NA	up to 2,322 European ancestry individuals from 118 families	European(2322)	ALL(2322)	EUR(2322)	ALL(2322)	Substance dependence phenotypes	HPOID:0001939	Abnormality of metabolism/homeostasis	DOID:9973	substance dependence	NA	NA	NA	NA	Drug abuse	NA	Research Support, N.I.H., Extramural	T	NOX3
7	9234364	rs17203026	C	T	rs17203026	21818250	1.14E-04	Illegal drug dependence	NA	NA	1171 European ancestry dependent cases; 1395 European ancestry controls; 652 African American ancestry cases; 499 African American ancestry controls	African American(1151)	European(2566)	ALL(3717)	AFR(1151)	EUR(2566)	ALL(3717)	Substance dependence	HPOID:0000707	Abnormality of the nervous system	DOID:9973	substance dependence	NA	NA	NA	NA	Drug abuse	NA	Research Support, N.I.H., Extramural
7	11290187	rs17539729	G	A	rs17539729	21818250	7.88E-04	Alcohol dependence	NA	NA	1171 European ancestry dependent cases; 1395 European ancestry controls; 652 African American ancestry cases; 499 African American ancestry controls	African American(1151)	European(2566)	ALL(3717)	AFR(1151)	EUR(2566)	ALL(3717)	Substance dependence	HPOID:0000707	Abnormality of the nervous system	DOID:9973	substance dependence	NA	NA	NA	NA	Drug abuse	NA	Research Support, N.I.H., Extramural
7	17064307	rs7804595	C	G	rs7804595	21818250	1.56E-05	Illegal drug dependence	NA	NA	1171 European ancestry dependent cases; 1395 European ancestry controls; 652 African American ancestry cases; 499 African American ancestry controls	African American(1151)	European(2566)	ALL(3717)	AFR(1151)	EUR(2566)	ALL(3717)	Substance dependence	HPOID:0000707	Abnormality of the nervous system	DOID:9973	substance dependence	NA	NA	NA	NA	Drug abuse	NA	Research Support, N.I.H., Extramural
7	50507678	rs963739	C	T	rs963739	21818250	6.76E-04	Alcohol dependence	NA	NA	1171 European ancestry dependent cases; 1395 European ancestry controls; 652 African American ancestry cases; 499 African American ancestry controls	African American(1151)	European(2566)	ALL(3717)	AFR(1151)	EUR(2566)	ALL(3717)	Substance dependence	HPOID:0000707	Abnormality of the nervous system	DOID:9973	substance dependence	NA	NA	NA	NA	Drug abuse	NA	Research Support, N.I.H., Extramural
7	104403270	rs10953450	T	A	rs10953450	21818250	7.87E-04	Illegal drug dependence	NA	NA	1171 European ancestry dependent cases; 1395 European ancestry controls; 652 African American ancestry cases; 499 African American ancestry controls	African American(1151)	European(2566)	ALL(3717)	AFR(1151)	EUR(2566)	ALL(3717)	Substance dependence	HPOID:0000707	Abnormality of the nervous system	DOID:9973	substance dependence	NA	NA	NA	NA	Drug abuse	NA	Research Support, N.I.H., Extramural
7	110017222	rs12155146	C	T	rs12155146	21818250	4.59E-04	Illegal drug dependence	NA	NA	1171 European ancestry dependent cases; 1395 European ancestry controls; 652 African American ancestry cases; 499 African American ancestry controls	African American(1151)	European(2566)	ALL(3717)	AFR(1151)	EUR(2566)	ALL(3717)	Substance dependence	HPOID:0000707	Abnormality of the nervous system	DOID:9973	substance dependence	NA	NA	NA	NA	Drug abuse	NA	Research Support, N.I.H., Extramural
7	154653720	rs10242745	T	C	rs10242745	21818250	3.28E-04	Illegal drug dependence	NA	NA	1171 European ancestry dependent cases; 1395 European ancestry controls; 652 African American ancestry cases; 499 African American ancestry controls	African American(1151)	European(2566)	ALL(3717)	AFR(1151)	EUR(2566)	ALL(3717)	Substance dependence	HPOID:0000707	Abnormality of the nervous system	DOID:9973	substance dependence	NA	NA	NA	NA	Drug abuse	NA	Research Support, N.I.H., Extramural
8	3053592	rs1077153	G	A,C,T	rs1077153	21818250	6.75E-04	Alcohol dependence	NA	NA	1171 European ancestry dependent cases; 1395 European ancestry controls; 652 African American ancestry cases; 499 African American ancestry controls	African American(1151)	European(2566)	ALL(3717)	AFR(1151)	EUR(2566)	ALL(3717)	Substance dependence	HPOID:0000707	Abnormality of the nervous system	DOID:9973	substance dependence	NA	NA	NA	NA	Drug abuse	NA	Research Support, N.I.H., Extramural
8	3564181	rs17067079	A	T	rs17067079	21818250	9.79E-06	Illegal drug dependence	NA	NA	1171 European ancestry dependent cases; 1395 European ancestry controls; 652 African American ancestry cases; 499 African American ancestry controls	African American(1151)	European(2566)	ALL(3717)	AFR(1151)	EUR(2566)	ALL(3717)	Substance dependence	HPOID:0000707	Abnormality of the nervous system	DOID:9973	substance dependence	NA	NA	NA	NA	Drug abuse	NA	Research Support, N.I.H., Extramural
8	18361385	rs12546956	C	T	rs12546956	21818250	6.57E-04	Alcohol dependence	NA	NA	1171 European ancestry dependent cases; 1395 European ancestry controls; 652 African American ancestry cases; 499 African American ancestry controls	African American(1151)	European(2566)	ALL(3717)	AFR(1151)	EUR(2566)	ALL(3717)	Substance dependence	HPOID:0000707	Abnormality of the nervous system	DOID:9973	substance dependence	NA	NA	NA	NA	Drug abuse	NA	Research Support, N.I.H., Extramural
8	21243101	rs1426186	G	T	rs1426186	21818250	6.82E-04	Illegal drug dependence	NA	NA	1171 European ancestry dependent cases; 1395 European ancestry controls; 652 African American ancestry cases; 499 African American ancestry controls	African American(1151)	European(2566)	ALL(3717)	AFR(1151)	EUR(2566)	ALL(3717)	Substance dependence	HPOID:0000707	Abnormality of the nervous system	DOID:9973	substance dependence	NA	NA	NA	NA	Drug abuse	NA	Research Support, N.I.H., Extramural
8	25648792	rs1978544	C	T	rs1978544	24832863	1.68E-06	NA	NA	NA	up to 2,322 European ancestry individuals from 118 families	European(2322)	ALL(2322)	EUR(2322)	ALL(2322)	Substance dependence phenotypes	HPOID:0001939	Abnormality of metabolism/homeostasis	DOID:9973	substance dependence	NA	NA	NA	NA	Drug abuse	NA	Research Support, N.I.H., Extramural	A	NA
8	61802987	rs4237043	C	G	rs4237043	21818250	6.49E-04	Illegal drug dependence	NA	NA	1171 European ancestry dependent cases; 1395 European ancestry controls; 652 African American ancestry cases; 499 African American ancestry controls	African American(1151)	European(2566)	ALL(3717)	AFR(1151)	EUR(2566)	ALL(3717)	Substance dependence	HPOID:0000707	Abnormality of the nervous system	DOID:9973	substance dependence	NA	NA	NA	NA	Drug abuse	NA	Research Support, N.I.H., Extramural
8	72195318	rs6989867	A	G	rs6989867	21818250	8.03E-04	Illegal drug dependence	NA	NA	1171 European ancestry dependent cases; 1395 European ancestry controls; 652 African American ancestry cases; 499 African American ancestry controls	African American(1151)	European(2566)	ALL(3717)	AFR(1151)	EUR(2566)	ALL(3717)	Substance dependence	HPOID:0000707	Abnormality of the nervous system	DOID:9973	substance dependence	NA	NA	NA	NA	Drug abuse	NA	Research Support, N.I.H., Extramural
8	96536023	rs11776832	G	A	rs11776832	24832863	5.63E-06	NA	NA	NA	up to 2,322 European ancestry individuals from 118 families	European(2322)	ALL(2322)	EUR(2322)	ALL(2322)	Substance dependence phenotypes	HPOID:0001939	Abnormality of metabolism/homeostasis	DOID:9973	substance dependence	NA	NA	NA	NA	Drug abuse	NA	Research Support, N.I.H., Extramural	G	LOC100616530
8	96536023	rs11776832	G	A	rs11776832	24832863	5.73E-04	NA	NA	NA	up to 2,322 European ancestry individuals from 118 families	European(2322)	ALL(2322)	EUR(2322)	ALL(2322)	Substance dependence phenotypes	HPOID:0001939	Abnormality of metabolism/homeostasis	DOID:9973	substance dependence	NA	NA	NA	NA	Drug abuse	NA	Research Support, N.I.H., Extramural	G	LOC100616530
8	102355663	rs4734024	C	T	rs4734024	21818250	2.02E-04	Illegal drug dependence	NA	NA	1171 European ancestry dependent cases; 1395 European ancestry controls; 652 African American ancestry cases; 499 African American ancestry controls	African American(1151)	European(2566)	ALL(3717)	AFR(1151)	EUR(2566)	ALL(3717)	Substance dependence	HPOID:0000707	Abnormality of the nervous system	DOID:9973	substance dependence	NA	NA	NA	NA	Drug abuse	NA	Research Support, N.I.H., Extramural
8	139299165	rs1512406	C	T	rs1512406	21818250	5.04E-04	Alcohol dependence	NA	NA	1171 European ancestry dependent cases; 1395 European ancestry controls; 652 African American ancestry cases; 499 African American ancestry controls	African American(1151)	European(2566)	ALL(3717)	AFR(1151)	EUR(2566)	ALL(3717)	Substance dependence	HPOID:0000707	Abnormality of the nervous system	DOID:9973	substance dependence	NA	NA	NA	NA	Drug abuse	NA	Research Support, N.I.H., Extramural
8	139303835	rs1512407	T	C	rs1512407	21818250	7.92E-05	Illegal drug dependence	NA	NA	1171 European ancestry dependent cases; 1395 European ancestry controls; 652 African American ancestry cases; 499 African American ancestry controls	African American(1151)	European(2566)	ALL(3717)	AFR(1151)	EUR(2566)	ALL(3717)	Substance dependence	HPOID:0000707	Abnormality of the nervous system	DOID:9973	substance dependence	NA	NA	NA	NA	Drug abuse	NA	Research Support, N.I.H., Extramural
9	1454200	rs4142436	T	C	rs4142436	21818250	5.52E-04	Illegal drug dependence	NA	NA	1171 European ancestry dependent cases; 1395 European ancestry controls; 652 African American ancestry cases; 499 African American ancestry controls	African American(1151)	European(2566)	ALL(3717)	AFR(1151)	EUR(2566)	ALL(3717)	Substance dependence	HPOID:0000707	Abnormality of the nervous system	DOID:9973	substance dependence	NA	NA	NA	NA	Drug abuse	NA	Research Support, N.I.H., Extramural
9	7150997	rs913581	T	C	rs913581	21818250	7.73E-04	Illegal drug dependence	NA	NA	1171 European ancestry dependent cases; 1395 European ancestry controls; 652 African American ancestry cases; 499 African American ancestry controls	African American(1151)	European(2566)	ALL(3717)	AFR(1151)	EUR(2566)	ALL(3717)	Substance dependence	HPOID:0000707	Abnormality of the nervous system	DOID:9973	substance dependence	NA	NA	NA	NA	Drug abuse	NA	Research Support, N.I.H., Extramural
9	9404896	rs10816124	C	A	rs10816124	21818250	7.94E-04	Illegal drug dependence	NA	NA	1171 European ancestry dependent cases; 1395 European ancestry controls; 652 African American ancestry cases; 499 African American ancestry controls	African American(1151)	European(2566)	ALL(3717)	AFR(1151)	EUR(2566)	ALL(3717)	Substance dependence	HPOID:0000707	Abnormality of the nervous system	DOID:9973	substance dependence	NA	NA	NA	NA	Drug abuse	NA	Research Support, N.I.H., Extramural
9	78917814	rs17062408	T	C	rs17062408	21818250	3.75E-04	Illegal drug dependence	NA	NA	1171 European ancestry dependent cases; 1395 European ancestry controls; 652 African American ancestry cases; 499 African American ancestry controls	African American(1151)	European(2566)	ALL(3717)	AFR(1151)	EUR(2566)	ALL(3717)	Substance dependence	HPOID:0000707	Abnormality of the nervous system	DOID:9973	substance dependence	NA	NA	NA	NA	Drug abuse	NA	Research Support, N.I.H., Extramural
9	83105978	rs1857471	T	A	rs1857471	21818250	2.72E-04	Illegal drug dependence	NA	NA	1171 European ancestry dependent cases; 1395 European ancestry controls; 652 African American ancestry cases; 499 African American ancestry controls	African American(1151)	European(2566)	ALL(3717)	AFR(1151)	EUR(2566)	ALL(3717)	Substance dependence	HPOID:0000707	Abnormality of the nervous system	DOID:9973	substance dependence	NA	NA	NA	NA	Drug abuse	NA	Research Support, N.I.H., Extramural
9	89236178	rs1411983	A	T	rs1411983	21818250	9.26E-05	Illegal drug dependence	NA	NA	1171 European ancestry dependent cases; 1395 European ancestry controls; 652 African American ancestry cases; 499 African American ancestry controls	African American(1151)	European(2566)	ALL(3717)	AFR(1151)	EUR(2566)	ALL(3717)	Substance dependence	HPOID:0000707	Abnormality of the nervous system	DOID:9973	substance dependence	NA	NA	NA	NA	Drug abuse	NA	Research Support, N.I.H., Extramural
9	92716596	rs16905942	G	A	rs16905942	21818250	1.66E-05	Illegal drug dependence	NA	NA	1171 European ancestry dependent cases; 1395 European ancestry controls; 652 African American ancestry cases; 499 African American ancestry controls	African American(1151)	European(2566)	ALL(3717)	AFR(1151)	EUR(2566)	ALL(3717)	Substance dependence	HPOID:0000707	Abnormality of the nervous system	DOID:9973	substance dependence	NA	NA	NA	NA	Drug abuse	NA	Research Support, N.I.H., Extramural
9	119766969	rs7042036	C	T	rs7042036	21818250	3.43E-04	Alcohol dependence	NA	NA	1171 European ancestry dependent cases; 1395 European ancestry controls; 652 African American ancestry cases; 499 African American ancestry controls	African American(1151)	European(2566)	ALL(3717)	AFR(1151)	EUR(2566)	ALL(3717)	Substance dependence	HPOID:0000707	Abnormality of the nervous system	DOID:9973	substance dependence	NA	NA	NA	NA	Drug abuse	NA	Research Support, N.I.H., Extramural
10	14375259	rs7082219	G	T	rs7082219	21818250	1.14E-04	Alcohol dependence	NA	NA	1171 European ancestry dependent cases; 1395 European ancestry controls; 652 African American ancestry cases; 499 African American ancestry controls	African American(1151)	European(2566)	ALL(3717)	AFR(1151)	EUR(2566)	ALL(3717)	Substance dependence	HPOID:0000707	Abnormality of the nervous system	DOID:9973	substance dependence	NA	NA	NA	NA	Drug abuse	NA	Research Support, N.I.H., Extramural
10	14385265	rs1218486	T	G	rs1218486	21818250	3.03E-04	Alcohol dependence	NA	NA	1171 European ancestry dependent cases; 1395 European ancestry controls; 652 African American ancestry cases; 499 African American ancestry controls	African American(1151)	European(2566)	ALL(3717)	AFR(1151)	EUR(2566)	ALL(3717)	Substance dependence	HPOID:0000707	Abnormality of the nervous system	DOID:9973	substance dependence	NA	NA	NA	NA	Drug abuse	NA	Research Support, N.I.H., Extramural
10	80131442	rs10490996	G	A	rs10490996	21818250	8.99E-04	Alcohol dependence	NA	NA	1171 European ancestry dependent cases; 1395 European ancestry controls; 652 African American ancestry cases; 499 African American ancestry controls	African American(1151)	European(2566)	ALL(3717)	AFR(1151)	EUR(2566)	ALL(3717)	Substance dependence	HPOID:0000707	Abnormality of the nervous system	DOID:9973	substance dependence	NA	NA	NA	NA	Drug abuse	NA	Research Support, N.I.H., Extramural
11	20659757	rs2298826	G	A	rs2298826	21818250	1.57E-04	Illegal drug dependence	NA	NA	1171 European ancestry dependent cases; 1395 European ancestry controls; 652 African American ancestry cases; 499 African American ancestry controls	African American(1151)	European(2566)	ALL(3717)	AFR(1151)	EUR(2566)	ALL(3717)	Substance dependence	HPOID:0000707	Abnormality of the nervous system	DOID:9973	substance dependence	NA	NA	NA	NA	Drug abuse	NA	Research Support, N.I.H., Extramural
11	63070493	rs1152240	T	A	rs1152240	21818250	8.48E-04	Illegal drug dependence	NA	NA	1171 European ancestry dependent cases; 1395 European ancestry controls; 652 African American ancestry cases; 499 African American ancestry controls	African American(1151)	European(2566)	ALL(3717)	AFR(1151)	EUR(2566)	ALL(3717)	Substance dependence	HPOID:0000707	Abnormality of the nervous system	DOID:9973	substance dependence	NA	NA	NA	NA	Drug abuse	NA	Research Support, N.I.H., Extramural
11	121779467	rs1078402	T	C	rs1078402	21818250	5.22E-04	Illegal drug dependence	NA	NA	1171 European ancestry dependent cases; 1395 European ancestry controls; 652 African American ancestry cases; 499 African American ancestry controls	African American(1151)	European(2566)	ALL(3717)	AFR(1151)	EUR(2566)	ALL(3717)	Substance dependence	HPOID:0000707	Abnormality of the nervous system	DOID:9973	substance dependence	NA	NA	NA	NA	Drug abuse	NA	Research Support, N.I.H., Extramural
11	125179853	rs12284594	A	G	rs12284594	21298047	7.00E-08	European women	1.77	NA	2,524 individuals of European ancestry; 1,103 individuals of African ancestry	African(1103)	European(2524)	ALL(3627)	AFR(1103)	EUR(2524)	ALL(3627)	Substance dependence	HPOID:0000707	Abnormality of the nervous system	DOID:9973	substance dependence	NA	NA	NA	NA	Drug abuse	rs12284594-G	Research Support, N.I.H., Extramural
12	3349894	rs17779114	T	G	rs17779114	21818250	1.41E-04	Illegal drug dependence	NA	NA	1171 European ancestry dependent cases; 1395 European ancestry controls; 652 African American ancestry cases; 499 African American ancestry controls	African American(1151)	European(2566)	ALL(3717)	AFR(1151)	EUR(2566)	ALL(3717)	Substance dependence	HPOID:0000707	Abnormality of the nervous system	DOID:9973	substance dependence	NA	NA	NA	NA	Drug abuse	NA	Research Support, N.I.H., Extramural
12	7383187	rs7962099	G	A	rs7962099	24832863	5.90E-06	NA	NA	NA	up to 2,322 European ancestry individuals from 118 families	European(2322)	ALL(2322)	EUR(2322)	ALL(2322)	Substance dependence phenotypes	HPOID:0001939	Abnormality of metabolism/homeostasis	DOID:9973	substance dependence	NA	NA	NA	NA	Drug abuse	NA	Research Support, N.I.H., Extramural	G	NA
12	7383187	rs7962099	G	A	rs7962099	24832863	8.26E-04	NA	NA	NA	up to 2,322 European ancestry individuals from 118 families	European(2322)	ALL(2322)	EUR(2322)	ALL(2322)	Substance dependence phenotypes	HPOID:0001939	Abnormality of metabolism/homeostasis	DOID:9973	substance dependence	NA	NA	NA	NA	Drug abuse	NA	Research Support, N.I.H., Extramural	G	NA
12	31201922	rs11051219	C	A	rs11051219	21818250	3.19E-04	Illegal drug dependence	NA	NA	1171 European ancestry dependent cases; 1395 European ancestry controls; 652 African American ancestry cases; 499 African American ancestry controls	African American(1151)	European(2566)	ALL(3717)	AFR(1151)	EUR(2566)	ALL(3717)	Substance dependence	HPOID:0000707	Abnormality of the nervous system	DOID:9973	substance dependence	NA	NA	NA	NA	Drug abuse	NA	Research Support, N.I.H., Extramural
12	66944945	rs10748053	G	A	rs10748053	21818250	8.18E-04	Alcohol dependence	NA	NA	1171 European ancestry dependent cases; 1395 European ancestry controls; 652 African American ancestry cases; 499 African American ancestry controls	African American(1151)	European(2566)	ALL(3717)	AFR(1151)	EUR(2566)	ALL(3717)	Substance dependence	HPOID:0000707	Abnormality of the nervous system	DOID:9973	substance dependence	NA	NA	NA	NA	Drug abuse	NA	Research Support, N.I.H., Extramural
12	72719792	rs17783131	A	C	rs17783131	21818250	6.08E-04	Illegal drug dependence	NA	NA	1171 European ancestry dependent cases; 1395 European ancestry controls; 652 African American ancestry cases; 499 African American ancestry controls	African American(1151)	European(2566)	ALL(3717)	AFR(1151)	EUR(2566)	ALL(3717)	Substance dependence	HPOID:0000707	Abnormality of the nervous system	DOID:9973	substance dependence	NA	NA	NA	NA	Drug abuse	NA	Research Support, N.I.H., Extramural
12	89635823	rs1091646	G	A	rs1091646	21818250	7.37E-04	Illegal drug dependence	NA	NA	1171 European ancestry dependent cases; 1395 European ancestry controls; 652 African American ancestry cases; 499 African American ancestry controls	African American(1151)	European(2566)	ALL(3717)	AFR(1151)	EUR(2566)	ALL(3717)	Substance dependence	HPOID:0000707	Abnormality of the nervous system	DOID:9973	substance dependence	NA	NA	NA	NA	Drug abuse	NA	Research Support, N.I.H., Extramural
12	96923355	rs7314750	T	G	rs7314750	24832863	9.93E-06	NA	NA	NA	up to 2,322 European ancestry individuals from 118 families	European(2322)	ALL(2322)	EUR(2322)	ALL(2322)	Substance dependence phenotypes	HPOID:0001939	Abnormality of metabolism/homeostasis	DOID:9973	substance dependence	NA	NA	NA	NA	Drug abuse	NA	Research Support, N.I.H., Extramural	T	C12orf55
12	125590417	rs7970937	T	C	rs7970937	21818250	2.13E-04	Illegal drug dependence	NA	NA	1171 European ancestry dependent cases; 1395 European ancestry controls; 652 African American ancestry cases; 499 African American ancestry controls	African American(1151)	European(2566)	ALL(3717)	AFR(1151)	EUR(2566)	ALL(3717)	Substance dependence	HPOID:0000707	Abnormality of the nervous system	DOID:9973	substance dependence	NA	NA	NA	NA	Drug abuse	NA	Research Support, N.I.H., Extramural
13	68435679	rs9564436	C	G	rs9564436	21818250	2.34E-04	Illegal drug dependence	NA	NA	1171 European ancestry dependent cases; 1395 European ancestry controls; 652 African American ancestry cases; 499 African American ancestry controls	African American(1151)	European(2566)	ALL(3717)	AFR(1151)	EUR(2566)	ALL(3717)	Substance dependence	HPOID:0000707	Abnormality of the nervous system	DOID:9973	substance dependence	NA	NA	NA	NA	Drug abuse	NA	Research Support, N.I.H., Extramural
13	95901825	rs9590213	A	T	rs9590213	21818250	1.54E-04	Illegal drug dependence	NA	NA	1171 European ancestry dependent cases; 1395 European ancestry controls; 652 African American ancestry cases; 499 African American ancestry controls	African American(1151)	European(2566)	ALL(3717)	AFR(1151)	EUR(2566)	ALL(3717)	Substance dependence	HPOID:0000707	Abnormality of the nervous system	DOID:9973	substance dependence	NA	NA	NA	NA	Drug abuse	NA	Research Support, N.I.H., Extramural
14	80317460	rs2293839	G	A	rs2293839	21818250	7.33E-04	Illegal drug dependence	NA	NA	1171 European ancestry dependent cases; 1395 European ancestry controls; 652 African American ancestry cases; 499 African American ancestry controls	African American(1151)	European(2566)	ALL(3717)	AFR(1151)	EUR(2566)	ALL(3717)	Substance dependence	HPOID:0000707	Abnormality of the nervous system	DOID:9973	substance dependence	NA	NA	NA	NA	Drug abuse	NA	Research Support, N.I.H., Extramural
14	81763478	rs17111687	G	A	rs17111687	21818250	9.60E-05	Illegal drug dependence	NA	NA	1171 European ancestry dependent cases; 1395 European ancestry controls; 652 African American ancestry cases; 499 African American ancestry controls	African American(1151)	European(2566)	ALL(3717)	AFR(1151)	EUR(2566)	ALL(3717)	Substance dependence	HPOID:0000707	Abnormality of the nervous system	DOID:9973	substance dependence	NA	NA	NA	NA	Drug abuse	NA	Research Support, N.I.H., Extramural
14	84184538	rs12587990	C	A	rs12587990	21818250	1.09E-04	Illegal drug dependence	NA	NA	1171 European ancestry dependent cases; 1395 European ancestry controls; 652 African American ancestry cases; 499 African American ancestry controls	African American(1151)	European(2566)	ALL(3717)	AFR(1151)	EUR(2566)	ALL(3717)	Substance dependence	HPOID:0000707	Abnormality of the nervous system	DOID:9973	substance dependence	NA	NA	NA	NA	Drug abuse	NA	Research Support, N.I.H., Extramural
14	86017922	rs985620	A	G	rs985620	21818250	1.98E-04	Illegal drug dependence	NA	NA	1171 European ancestry dependent cases; 1395 European ancestry controls; 652 African American ancestry cases; 499 African American ancestry controls	African American(1151)	European(2566)	ALL(3717)	AFR(1151)	EUR(2566)	ALL(3717)	Substance dependence	HPOID:0000707	Abnormality of the nervous system	DOID:9973	substance dependence	NA	NA	NA	NA	Drug abuse	NA	Research Support, N.I.H., Extramural
14	94941587	rs11626091	G	A	rs11626091	21818250	2.74E-05	Alcohol dependence	NA	NA	1171 European ancestry dependent cases; 1395 European ancestry controls; 652 African American ancestry cases; 499 African American ancestry controls	African American(1151)	European(2566)	ALL(3717)	AFR(1151)	EUR(2566)	ALL(3717)	Substance dependence	HPOID:0000707	Abnormality of the nervous system	DOID:9973	substance dependence	NA	NA	NA	NA	Drug abuse	NA	Research Support, N.I.H., Extramural
15	27185306	rs28551016	C	T	rs28551016	21818250	8.86E-04	Alcohol dependence	NA	NA	1171 European ancestry dependent cases; 1395 European ancestry controls; 652 African American ancestry cases; 499 African American ancestry controls	African American(1151)	European(2566)	ALL(3717)	AFR(1151)	EUR(2566)	ALL(3717)	Substance dependence	HPOID:0000707	Abnormality of the nervous system	DOID:9973	substance dependence	NA	NA	NA	NA	Drug abuse	NA	Research Support, N.I.H., Extramural
15	57594066	rs2440979	T	C	rs2440979	21818250	5.14E-04	Alcohol dependence	NA	NA	1171 European ancestry dependent cases; 1395 European ancestry controls; 652 African American ancestry cases; 499 African American ancestry controls	African American(1151)	European(2566)	ALL(3717)	AFR(1151)	EUR(2566)	ALL(3717)	Substance dependence	HPOID:0000707	Abnormality of the nervous system	DOID:9973	substance dependence	NA	NA	NA	NA	Drug abuse	NA	Research Support, N.I.H., Extramural
15	57604402	rs4774925	T	C	rs4774925	21818250	7.62E-04	Illegal drug dependence	NA	NA	1171 European ancestry dependent cases; 1395 European ancestry controls; 652 African American ancestry cases; 499 African American ancestry controls	African American(1151)	European(2566)	ALL(3717)	AFR(1151)	EUR(2566)	ALL(3717)	Substance dependence	HPOID:0000707	Abnormality of the nervous system	DOID:9973	substance dependence	NA	NA	NA	NA	Drug abuse	NA	Research Support, N.I.H., Extramural
15	73067234	rs11634630	T	C	rs11634630	21818250	4.03E-04	Illegal drug dependence	NA	NA	1171 European ancestry dependent cases; 1395 European ancestry controls; 652 African American ancestry cases; 499 African American ancestry controls	African American(1151)	European(2566)	ALL(3717)	AFR(1151)	EUR(2566)	ALL(3717)	Substance dependence	HPOID:0000707	Abnormality of the nervous system	DOID:9973	substance dependence	NA	NA	NA	NA	Drug abuse	NA	Research Support, N.I.H., Extramural
15	79741593	rs7169963	T	G	rs7169963	21818250	6.33E-04	Alcohol dependence	NA	NA	1171 European ancestry dependent cases; 1395 European ancestry controls; 652 African American ancestry cases; 499 African American ancestry controls	African American(1151)	European(2566)	ALL(3717)	AFR(1151)	EUR(2566)	ALL(3717)	Substance dependence	HPOID:0000707	Abnormality of the nervous system	DOID:9973	substance dependence	NA	NA	NA	NA	Drug abuse	NA	Research Support, N.I.H., Extramural
15	79975749	rs4778721	C	T	rs4778721	21818250	8.16E-04	Illegal drug dependence	NA	NA	1171 European ancestry dependent cases; 1395 European ancestry controls; 652 African American ancestry cases; 499 African American ancestry controls	African American(1151)	European(2566)	ALL(3717)	AFR(1151)	EUR(2566)	ALL(3717)	Substance dependence	HPOID:0000707	Abnormality of the nervous system	DOID:9973	substance dependence	NA	NA	NA	NA	Drug abuse	NA	Research Support, N.I.H., Extramural
15	98044868	rs1500642	A	T	rs1500642	21818250	9.97E-06	Illegal drug dependence	NA	NA	1171 European ancestry dependent cases; 1395 European ancestry controls; 652 African American ancestry cases; 499 African American ancestry controls	African American(1151)	European(2566)	ALL(3717)	AFR(1151)	EUR(2566)	ALL(3717)	Substance dependence	HPOID:0000707	Abnormality of the nervous system	DOID:9973	substance dependence	NA	NA	NA	NA	Drug abuse	NA	Research Support, N.I.H., Extramural
16	5817372	rs1865814	A	C	rs1865814	21818250	7.16E-05	Illegal drug dependence	NA	NA	1171 European ancestry dependent cases; 1395 European ancestry controls; 652 African American ancestry cases; 499 African American ancestry controls	African American(1151)	European(2566)	ALL(3717)	AFR(1151)	EUR(2566)	ALL(3717)	Substance dependence	HPOID:0000707	Abnormality of the nervous system	DOID:9973	substance dependence	NA	NA	NA	NA	Drug abuse	NA	Research Support, N.I.H., Extramural
16	12590176	rs9806891	C	T	rs9806891	24832863	2.30E-05	NA	NA	NA	up to 2,322 European ancestry individuals from 118 families	European(2322)	ALL(2322)	EUR(2322)	ALL(2322)	Substance dependence phenotypes	HPOID:0001939	Abnormality of metabolism/homeostasis	DOID:9973	substance dependence	NA	NA	NA	NA	Drug abuse	NA	Research Support, N.I.H., Extramural	T	SNX29
16	12590176	rs9806891	C	T	rs9806891	24832863	7.55E-06	NA	NA	NA	up to 2,322 European ancestry individuals from 118 families	European(2322)	ALL(2322)	EUR(2322)	ALL(2322)	Substance dependence phenotypes	HPOID:0001939	Abnormality of metabolism/homeostasis	DOID:9973	substance dependence	NA	NA	NA	NA	Drug abuse	NA	Research Support, N.I.H., Extramural	T	SNX29
16	13798132	rs12927885	C	T	rs12927885	21818250	5.68E-04	Alcohol dependence	NA	NA	1171 European ancestry dependent cases; 1395 European ancestry controls; 652 African American ancestry cases; 499 African American ancestry controls	African American(1151)	European(2566)	ALL(3717)	AFR(1151)	EUR(2566)	ALL(3717)	Substance dependence	HPOID:0000707	Abnormality of the nervous system	DOID:9973	substance dependence	NA	NA	NA	NA	Drug abuse	NA	Research Support, N.I.H., Extramural
16	63627883	rs1862751	T	A	rs1862751	21818250	6.07E-04	Illegal drug dependence	NA	NA	1171 European ancestry dependent cases; 1395 European ancestry controls; 652 African American ancestry cases; 499 African American ancestry controls	African American(1151)	European(2566)	ALL(3717)	AFR(1151)	EUR(2566)	ALL(3717)	Substance dependence	HPOID:0000707	Abnormality of the nervous system	DOID:9973	substance dependence	NA	NA	NA	NA	Drug abuse	NA	Research Support, N.I.H., Extramural
16	65719331	rs2045925	A	G	rs2045925	21818250	4.17E-04	Illegal drug dependence	NA	NA	1171 European ancestry dependent cases; 1395 European ancestry controls; 652 African American ancestry cases; 499 African American ancestry controls	African American(1151)	European(2566)	ALL(3717)	AFR(1151)	EUR(2566)	ALL(3717)	Substance dependence	HPOID:0000707	Abnormality of the nervous system	DOID:9973	substance dependence	NA	NA	NA	NA	Drug abuse	NA	Research Support, N.I.H., Extramural
16	80655883	rs12448290	T	G	rs12448290	21818250	6.69E-04	Alcohol dependence	NA	NA	1171 European ancestry dependent cases; 1395 European ancestry controls; 652 African American ancestry cases; 499 African American ancestry controls	African American(1151)	European(2566)	ALL(3717)	AFR(1151)	EUR(2566)	ALL(3717)	Substance dependence	HPOID:0000707	Abnormality of the nervous system	DOID:9973	substance dependence	NA	NA	NA	NA	Drug abuse	NA	Research Support, N.I.H., Extramural
16	82936043	rs9319578	A	G	rs9319578	21818250	5.41E-05	Illegal drug dependence	NA	NA	1171 European ancestry dependent cases; 1395 European ancestry controls; 652 African American ancestry cases; 499 African American ancestry controls	African American(1151)	European(2566)	ALL(3717)	AFR(1151)	EUR(2566)	ALL(3717)	Substance dependence	HPOID:0000707	Abnormality of the nervous system	DOID:9973	substance dependence	NA	NA	NA	NA	Drug abuse	NA	Research Support, N.I.H., Extramural
16	86668566	rs16941722	A	C	rs16941722	21818250	4.97E-04	Illegal drug dependence	NA	NA	1171 European ancestry dependent cases; 1395 European ancestry controls; 652 African American ancestry cases; 499 African American ancestry controls	African American(1151)	European(2566)	ALL(3717)	AFR(1151)	EUR(2566)	ALL(3717)	Substance dependence	HPOID:0000707	Abnormality of the nervous system	DOID:9973	substance dependence	NA	NA	NA	NA	Drug abuse	NA	Research Support, N.I.H., Extramural
17	31789102	rs952540	T	C	rs952540	21818250	1.74E-04	Alcohol dependence	NA	NA	1171 European ancestry dependent cases; 1395 European ancestry controls; 652 African American ancestry cases; 499 African American ancestry controls	African American(1151)	European(2566)	ALL(3717)	AFR(1151)	EUR(2566)	ALL(3717)	Substance dependence	HPOID:0000707	Abnormality of the nervous system	DOID:9973	substance dependence	NA	NA	NA	NA	Drug abuse	NA	Research Support, N.I.H., Extramural
17	68303286	rs7225313	C	A	rs7225313	21818250	5.24E-04	Alcohol dependence	NA	NA	1171 European ancestry dependent cases; 1395 European ancestry controls; 652 African American ancestry cases; 499 African American ancestry controls	African American(1151)	European(2566)	ALL(3717)	AFR(1151)	EUR(2566)	ALL(3717)	Substance dependence	HPOID:0000707	Abnormality of the nervous system	DOID:9973	substance dependence	NA	NA	NA	NA	Drug abuse	NA	Research Support, N.I.H., Extramural
17	68316459	rs16975551	C	T	rs16975551	21818250	2.00E-04	Illegal drug dependence	NA	NA	1171 European ancestry dependent cases; 1395 European ancestry controls; 652 African American ancestry cases; 499 African American ancestry controls	African American(1151)	European(2566)	ALL(3717)	AFR(1151)	EUR(2566)	ALL(3717)	Substance dependence	HPOID:0000707	Abnormality of the nervous system	DOID:9973	substance dependence	NA	NA	NA	NA	Drug abuse	NA	Research Support, N.I.H., Extramural
17	74988840	rs3848391	C	T	rs3848391	24832863	6.27E-06	NA	NA	NA	up to 2,322 European ancestry individuals from 118 families	European(2322)	ALL(2322)	EUR(2322)	ALL(2322)	Substance dependence phenotypes	HPOID:0001939	Abnormality of metabolism/homeostasis	DOID:9973	substance dependence	NA	NA	NA	NA	Drug abuse	NA	Research Support, N.I.H., Extramural	C	NA
17	74995894	rs4789398	C	T	rs4789398	24832863	6.61E-06	NA	NA	NA	up to 2,322 European ancestry individuals from 118 families	European(2322)	ALL(2322)	EUR(2322)	ALL(2322)	Substance dependence phenotypes	HPOID:0001939	Abnormality of metabolism/homeostasis	DOID:9973	substance dependence	NA	NA	NA	NA	Drug abuse	NA	Research Support, N.I.H., Extramural	T,C	NA
18	6868925	rs2567261	T	C	rs2567261	24832863	3.18E-04	NA	NA	NA	up to 2,322 European ancestry individuals from 118 families	European(2322)	ALL(2322)	EUR(2322)	ALL(2322)	Substance dependence phenotypes	HPOID:0001939	Abnormality of metabolism/homeostasis	DOID:9973	substance dependence	NA	NA	NA	NA	Drug abuse	NA	Research Support, N.I.H., Extramural	A	ARHGAP28
18	6868925	rs2567261	T	C	rs2567261	24832863	3.76E-08	NA	NA	NA	up to 2,322 European ancestry individuals from 118 families	European(2322)	ALL(2322)	EUR(2322)	ALL(2322)	Substance dependence phenotypes	HPOID:0001939	Abnormality of metabolism/homeostasis	DOID:9973	substance dependence	NA	NA	NA	NA	Drug abuse	NA	Research Support, N.I.H., Extramural	A	ARHGAP28
18	53857981	rs11151630	C	A	rs11151630	21818250	6.84E-04	Illegal drug dependence	NA	NA	1171 European ancestry dependent cases; 1395 European ancestry controls; 652 African American ancestry cases; 499 African American ancestry controls	African American(1151)	European(2566)	ALL(3717)	AFR(1151)	EUR(2566)	ALL(3717)	Substance dependence	HPOID:0000707	Abnormality of the nervous system	DOID:9973	substance dependence	NA	NA	NA	NA	Drug abuse	NA	Research Support, N.I.H., Extramural
18	68043316	rs7244215	G	A	rs7244215	21818250	6.80E-04	Alcohol dependence	NA	NA	1171 European ancestry dependent cases; 1395 European ancestry controls; 652 African American ancestry cases; 499 African American ancestry controls	African American(1151)	European(2566)	ALL(3717)	AFR(1151)	EUR(2566)	ALL(3717)	Substance dependence	HPOID:0000707	Abnormality of the nervous system	DOID:9973	substance dependence	NA	NA	NA	NA	Drug abuse	NA	Research Support, N.I.H., Extramural
20	15902630	rs6034328	C	T	rs6034328	21818250	4.87E-04	Alcohol dependence	NA	NA	1171 European ancestry dependent cases; 1395 European ancestry controls; 652 African American ancestry cases; 499 African American ancestry controls	African American(1151)	European(2566)	ALL(3717)	AFR(1151)	EUR(2566)	ALL(3717)	Substance dependence	HPOID:0000707	Abnormality of the nervous system	DOID:9973	substance dependence	NA	NA	NA	NA	Drug abuse	NA	Research Support, N.I.H., Extramural
20	20059715	rs9808594	C	T	rs9808594	21818250	5.69E-04	Illegal drug dependence	NA	NA	1171 European ancestry dependent cases; 1395 European ancestry controls; 652 African American ancestry cases; 499 African American ancestry controls	African American(1151)	European(2566)	ALL(3717)	AFR(1151)	EUR(2566)	ALL(3717)	Substance dependence	HPOID:0000707	Abnormality of the nervous system	DOID:9973	substance dependence	NA	NA	NA	NA	Drug abuse	NA	Research Support, N.I.H., Extramural
20	51720422	rs16997525	T	C	rs16997525	21818250	5.30E-04	Alcohol dependence	NA	NA	1171 European ancestry dependent cases; 1395 European ancestry controls; 652 African American ancestry cases; 499 African American ancestry controls	African American(1151)	European(2566)	ALL(3717)	AFR(1151)	EUR(2566)	ALL(3717)	Substance dependence	HPOID:0000707	Abnormality of the nervous system	DOID:9973	substance dependence	NA	NA	NA	NA	Drug abuse	NA	Research Support, N.I.H., Extramural
21	41524631	rs11911749	T	C	rs11911749	21818250	3.25E-04	Illegal drug dependence	NA	NA	1171 European ancestry dependent cases; 1395 European ancestry controls; 652 African American ancestry cases; 499 African American ancestry controls	African American(1151)	European(2566)	ALL(3717)	AFR(1151)	EUR(2566)	ALL(3717)	Substance dependence	HPOID:0000707	Abnormality of the nervous system	DOID:9973	substance dependence	NA	NA	NA	NA	Drug abuse	NA	Research Support, N.I.H., Extramural
22	17318150	rs165611	T	C	rs165611	21818250	1.02E-04	Alcohol dependence	NA	NA	1171 European ancestry dependent cases; 1395 European ancestry controls; 652 African American ancestry cases; 499 African American ancestry controls	African American(1151)	European(2566)	ALL(3717)	AFR(1151)	EUR(2566)	ALL(3717)	Substance dependence	HPOID:0000707	Abnormality of the nervous system	DOID:9973	substance dependence	NA	NA	NA	NA	Drug abuse	NA	Research Support, N.I.H., Extramural
22	17326432	rs2075120	C	T	rs2075120	21818250	1.62E-04	Illegal drug dependence	NA	NA	1171 European ancestry dependent cases; 1395 European ancestry controls; 652 African American ancestry cases; 499 African American ancestry controls	African American(1151)	European(2566)	ALL(3717)	AFR(1151)	EUR(2566)	ALL(3717)	Substance dependence	HPOID:0000707	Abnormality of the nervous system	DOID:9973	substance dependence	NA	NA	NA	NA	Drug abuse	NA	Research Support, N.I.H., Extramural
22	26713964	rs6519647	G	T	rs6519647	24832863	2.71E-04	NA	NA	NA	up to 2,322 European ancestry individuals from 118 families	European(2322)	ALL(2322)	EUR(2322)	ALL(2322)	Substance dependence phenotypes	HPOID:0001939	Abnormality of metabolism/homeostasis	DOID:9973	substance dependence	NA	NA	NA	NA	Drug abuse	NA	Research Support, N.I.H., Extramural	G	SEZ6L
22	26713964	rs6519647	G	T	rs6519647	24832863	4.62E-07	NA	NA	NA	up to 2,322 European ancestry individuals from 118 families	European(2322)	ALL(2322)	EUR(2322)	ALL(2322)	Substance dependence phenotypes	HPOID:0001939	Abnormality of metabolism/homeostasis	DOID:9973	substance dependence	NA	NA	NA	NA	Drug abuse	NA	Research Support, N.I.H., Extramural	G	SEZ6L
22	26715923	rs3788378	G	A	rs3788378	24832863	1.57E-04	NA	NA	NA	up to 2,322 European ancestry individuals from 118 families	European(2322)	ALL(2322)	EUR(2322)	ALL(2322)	Substance dependence phenotypes	HPOID:0001939	Abnormality of metabolism/homeostasis	DOID:9973	substance dependence	NA	NA	NA	NA	Drug abuse	NA	Research Support, N.I.H., Extramural	G	SEZ6L
22	26715923	rs3788378	G	A	rs3788378	24832863	6.78E-06	NA	NA	NA	up to 2,322 European ancestry individuals from 118 families	European(2322)	ALL(2322)	EUR(2322)	ALL(2322)	Substance dependence phenotypes	HPOID:0001939	Abnormality of metabolism/homeostasis	DOID:9973	substance dependence	NA	NA	NA	NA	Drug abuse	NA	Research Support, N.I.H., Extramural	G	SEZ6L
22	30846623	rs5753152	A	G	rs5753152	21818250	2.18E-04	Illegal drug dependence	NA	NA	1171 European ancestry dependent cases; 1395 European ancestry controls; 652 African American ancestry cases; 499 African American ancestry controls	African American(1151)	European(2566)	ALL(3717)	AFR(1151)	EUR(2566)	ALL(3717)	Substance dependence	HPOID:0000707	Abnormality of the nervous system	DOID:9973	substance dependence	NA	NA	NA	NA	Drug abuse	NA	Research Support, N.I.H., Extramural

Mapped by lexical matching(Total Items:0)
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Mapped by homologous gene(Total Items:0)
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Chemical(Total Drugs:0)
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FDA approved drug and dosage information(Total Drugs:0)
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FDA labeling changes(Total Drugs:0)
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