PedAM
Pediatric Disease Annotations & Medicines
| substance abuse | ||||
| Disease ID | 1800 |
|---|---|
| Disease | substance abuse |
| Manually Symptom | (Waiting for update.) |
| Text Mined Symptom | (Waiting for update.) |
Manually Genotype(Total Text Mining Genotypes:0) |
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| (Waiting for update.) |
All Snps(Total Genotypes:9) | |||||||||||||
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| snpId | pubmedId | geneId | geneSymbol | diseaseId | sourceId | sentence | score | Year | geneSymbol_dbSNP | CHROMOSOME | POS | REF | ALT |
| rs1039002 | 22205951 | 10846 | PDE10A | umls:C0740858 | BeFree | Bipolar disorder with psychosis and/or substance abuse in the absence of alcohol dependence was associated with the rare variant rs1039002 in the vicinity of the gene phosphodiesterase 10A (PDE10A) on chromosome 6q27 (p = 1.7×10⁻⁸). | 0.000271442 | 2011 | NA | 6 | 165741969 | G | A |
| rs1801028 | 9650635 | 1813 | DRD2 | umls:C0740858 | BeFree | A functionally deficient DRD2 variant [Ser311Cys] is not linked to alcoholism and substance abuse. | 0.003800186 | 1998 | DRD2 | 11 | 113412762 | G | C |
| rs2023239 | 18705688 | 1268 | CNR1 | umls:C0740858 | BeFree | Two single nucleotide polymorphisms (SNPs) in the CNR1 (rs2023239) and FAAH (rs324420) genes, associated previously with substance abuse and functional changes in cannabinoid regulation, were examined in a sample of daily marijuana smokers. | 0.002909916 | 2008 | CNR1 | 6 | 88150763 | T | C |
| rs2023239 | 18705688 | 2166 | FAAH | umls:C0740858 | BeFree | Two single nucleotide polymorphisms (SNPs) in the CNR1 (rs2023239) and FAAH (rs324420) genes, associated previously with substance abuse and functional changes in cannabinoid regulation, were examined in a sample of daily marijuana smokers. | 0.002909916 | 2008 | CNR1 | 6 | 88150763 | T | C |
| rs324420 | 18705688 | 1268 | CNR1 | umls:C0740858 | BeFree | Two single nucleotide polymorphisms (SNPs) in the CNR1 (rs2023239) and FAAH (rs324420) genes, associated previously with substance abuse and functional changes in cannabinoid regulation, were examined in a sample of daily marijuana smokers. | 0.002909916 | 2008 | FAAH | 1 | 46405089 | C | A |
| rs324420 | 18705688 | 2166 | FAAH | umls:C0740858 | BeFree | Two single nucleotide polymorphisms (SNPs) in the CNR1 (rs2023239) and FAAH (rs324420) genes, associated previously with substance abuse and functional changes in cannabinoid regulation, were examined in a sample of daily marijuana smokers. | 0.002909916 | 2008 | FAAH | 1 | 46405089 | C | A |
| rs324420 | 17621164 | 2166 | FAAH | umls:C0740858 | BeFree | Owing to the importance of endocannabinoid system in addiction, the Pro129Thr polymorphism in the FAAH gene has reportedly been associated with substance abuse and dependence in a Caucasian population. | 0.002909916 | 2007 | FAAH | 1 | 46405089 | C | A |
| rs386602118 | 16109452 | 627 | BDNF | umls:C0740858 | BeFree | Brain-derived neurotrophic factor (Val66Met) genetic polymorphism is associated with substance abuse in males. | 0.003724241 | 2005 | NA | NA | NA | NA | NA |
| rs6296 | 12496953 | 3351 | HTR1B | umls:C0740858 | BeFree | Substance abuse disorder and major depression are associated with the human 5-HT1B receptor gene (HTR1B) G861C polymorphism. | 0.002909916 | 2003 | HTR1B;LOC105377864 | 6 | 77462543 | C | G |
GWASdb Annotation(Total Genotypes:0) | |
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| (Waiting for update.) | |
GWASdb Snp Trait(Total Genotypes:0) | |
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| (Waiting for update.) | |
Mapped by lexical matching(Total Items:0) |
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| (Waiting for update.) |
Mapped by homologous gene(Total Items:0) |
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| (Waiting for update.) |
Chemical(Total Drugs:0) | |
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| (Waiting for update.) | |
FDA approved drug and dosage information(Total Drugs:0) | |
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| (Waiting for update.) | |
FDA labeling changes(Total Drugs:0) | |
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| (Waiting for update.) | |