PedAM

Pediatric Disease Annotations & Medicines


	stress cardiomyopathy

Disease ID	801
Disease	stress cardiomyopathy
Definition	A transient left ventricular apical dysfunction or ballooning accompanied by electrocardiographic (ECG) T wave inversions. This abnormality is associated with high levels of CATECHOLAMINES, either administered or endogenously secreted from a tumor or during extreme stress.
Synonym	apical ballooning syndrome broken heart syndrome broken-heart syndrome cardiomyopathy, stress cardiomyopathy, tako-tsubo cardiomyopathy, takotsubo left ventricular apical ballooning syndrome left ventricular ballooning syndrome syndrome, apical ballooning syndrome, broken heart syndrome, tako-tsubo syndromes, broken heart syndromes, tako-tsubo tako tsubo cardiomyopathy tako tsubo syndrome tako-tsubo cardiomyopathy tako-tsubo syndrome tako-tsubo syndromes takotsubo cardiomyopathy takotsubo cardiomyopathy (disorder) takotsubo cardiomyopathy [disease/finding] takotsubo syndrome transient apical ballooning syndrome
Orphanet	ORPHANET:66529
ICD10	ICD10CM:I51.81
UMLS	C1739395
MeSH	D054549
SNOMED-CT	SNOMEDCT_US_2016_09_01:441541008
Comorbidity	UMLS \| Disease \| Sentences' Count(Total Sentences:14) C0155626 \| acute myocardial infarction \| 2 C0027051 \| myocardial infarct \| 2 C0027051 \| myocardial infarction \| 2 C0003467 \| anxiety \| 1 C0031511 \| pheochromocytoma \| 1 C0040156 \| thyrotoxicosis \| 1 C0018801 \| heart failure \| 1 C0007194 \| obstructive cardiomyopathy \| 1 C0087086 \| thrombi \| 1 C0007194 \| hypertrophic obstructive cardiomyopathy \| 1 C0010068 \| coronary artery disease \| 1 C0024117 \| chronic obstructive airways disease \| 1 C0011570 \| depression \| 1 C0024796 \| marfan's syndrome \| 1
Curated Gene	(Waiting for update.)
Inferring Gene	Entrez_id \| Symbol \| Resource(Total Genes:4) 153 \| ADRB1 \| infer 154 \| ADRB2 \| infer 2778 \| GNAS \| infer 2869 \| GRK5 \| infer
Text Mined Gene	(Waiting for update.)
Locus	(Waiting for update.)

Disease ID	801
Disease	stress cardiomyopathy
Integrated Phenotype	(Waiting for update.)
Text Mined Phenotype	HPO \| Name \| Sentences' Count(Total Phenotypes:11) HP:0001658 \| Myocardial infarction \| 2 HP:0004308 \| Ventricular arrhythmia \| 1 HP:0001677 \| Coronary artery disease \| 1 HP:0001635 \| Congestive heart failure \| 1 HP:0004756 \| Ventricular tachycardia \| 1 HP:0011675 \| Arrhythmias \| 1 HP:0000739 \| Anxiety \| 1 HP:0001695 \| Cardiac arrest \| 1 HP:0002138 \| Subarachnoid hemorrhage \| 1 HP:0000716 \| Depression \| 1 HP:0002666 \| Pheochromocytoma \| 1

Disease ID	801
Disease	stress cardiomyopathy
Manually Symptom	UMLS \| Name(Total Manually Symptoms:1) C0155919 \| acute pulmonary edema
Text Mined Symptom	(Waiting for update.)

Manually Genotype(Total Text Mining Genotypes:0)
(Waiting for update.)

All Snps(Total Genotypes:0)
(Waiting for update.)

GWASdb Annotation(Total Genotypes:0)
(Waiting for update.)

GWASdb Snp Trait(Total Genotypes:0)
(Waiting for update.)

Mapped by lexical matching(Total Items:0)
(Waiting for update.)

Mapped by homologous gene(Total Items:0)
(Waiting for update.)

Chemical(Total Drugs:7)
CUI	ChemicalName	ChemicalID	CasRN	DiseaseName	DiseaseID	DirectEvidence	PubMedIDs
C1739395	amphetamine	D000661	300-62-9	takotsubo cardiomyopathy	MESH:D054549	marker/mechanism	18177388
C1739395	disopyramide	D004206	3737/9/5	takotsubo cardiomyopathy	MESH:D054549	marker/mechanism	18827420
C1739395	fluorouracil	D005472	51-21-8	takotsubo cardiomyopathy	MESH:D054549	marker/mechanism	19300240
C1739395	metoprolol	D008790	37350-58-6	takotsubo cardiomyopathy	MESH:D054549	therapeutic	19300450
C1739395	nortriptyline	D009661	72-69-5	takotsubo cardiomyopathy	MESH:D054549	marker/mechanism	18568805
C1739395	succinylcholine	D013390	306-40-1	takotsubo cardiomyopathy	MESH:D054549	marker/mechanism	18829243
C1739395	zolmitriptan	C089750	-	takotsubo cardiomyopathy	MESH:D054549	marker/mechanism	24100257

FDA approved drug and dosage information(Total Drugs:0)
(Waiting for update.)

FDA labeling changes(Total Drugs:0)
(Waiting for update.)

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