PedAM

Pediatric Disease Annotations & Medicines


	speech disorder

Disease ID	1827
Disease	speech disorder
Definition	Acquired or developmental conditions marked by an impaired ability to comprehend or generate spoken forms of language.
Synonym	defect speech (nos) defects speech disorder speech disorders speech neurological speech impairment speech defect speech defects speech dis speech disorders speech disorders [disease/finding] speech impairment speech impediment speech impediment or impairment
DOID	DOID:92
UMLS	C0037822
MeSH	D013064
Comorbidity	UMLS \| Disease \| Sentences' Count(Total Sentences:12) C0008925 \| cleft palate \| 4 C0003537 \| aphasia \| 3 C0030567 \| parkinson's disease \| 2 C0030567 \| parkinson disease \| 2 C0016719 \| friedreich ataxia \| 1 C0013595 \| eczema \| 1 C0007789 \| cerebral palsy \| 1 C0085113 \| neurofibromatosis \| 1 C0016719 \| friedreich's ataxia \| 1 C0036341 \| schizophrenia \| 1 C0268151 \| classic galactosemia \| 1 C0004134 \| ataxia \| 1
Curated Gene	Entrez_id \| Symbol \| Resource(Total Genes:3) GRIN2A \| 2903 \| CTD_human MFSD2A \| 84879 \| CTD_human TTPA \| 7274 \| CTD_human
Inferring Gene	(Waiting for update.)
Text Mined Gene	Entrez_id \| Symbol \| Score \| Resource(Total Genes:155) 2896 \| GRN \| DISEASES 7132 \| TNFRSF1A \| DISEASES 84572 \| GNPTG \| DISEASES 1738 \| DLD \| DISEASES 3956 \| LGALS1 \| DISEASES 5816 \| PVALB \| DISEASES 51804 \| SIX4 \| DISEASES 54623 \| PAF1 \| DISEASES 23064 \| SETX \| DISEASES 1846 \| DUSP4 \| DISEASES 23435 \| TARDBP \| DISEASES 56269 \| IRGC \| DISEASES 92797 \| HELB \| DISEASES 25814 \| ATXN10 \| DISEASES 80762 \| NDFIP1 \| DISEASES 26284 \| ERAL1 \| DISEASES 182 \| JAG1 \| DISEASES 6926 \| TBX3 \| DISEASES 10017 \| BCL2L10 \| DISEASES 23431 \| AP4E1 \| DISEASES 81671 \| VMP1 \| DISEASES 284058 \| KANSL1 \| DISEASES 9914 \| ATP2C2 \| DISEASES 25939 \| SAMHD1 \| DISEASES 23523 \| CABIN1 \| DISEASES 2033 \| EP300 \| DISEASES 492 \| ATP2B3 \| DISEASES 84083 \| ZRANB3 \| DISEASES 10190 \| TXNDC9 \| DISEASES 119 \| ADD2 \| DISEASES 8506 \| CNTNAP1 \| DISEASES 793 \| CALB1 \| DISEASES 54816 \| ZNF280D \| DISEASES 4240 \| MFGE8 \| DISEASES 6531 \| SLC6A3 \| DISEASES 5860 \| QDPR \| DISEASES 23037 \| PDZD2 \| DISEASES 221895 \| JAZF1 \| DISEASES 6750 \| SST \| DISEASES 26060 \| APPL1 \| DISEASES 90525 \| SHF \| DISEASES 57465 \| TBC1D24 \| DISEASES 6006 \| RHCE \| DISEASES 26610 \| ELP4 \| DISEASES 2562 \| GABRB3 \| DISEASES 79158 \| GNPTAB \| DISEASES 478 \| ATP1A3 \| DISEASES 1816 \| DRD5 \| DISEASES 3913 \| LAMB2 \| DISEASES 794 \| CALB2 \| DISEASES 171389 \| NLRP6 \| DISEASES 23209 \| MLC1 \| DISEASES 51172 \| NAGPA \| DISEASES 80025 \| PANK2 \| DISEASES 151516 \| ASPRV1 \| DISEASES 1604 \| CD55 \| DISEASES 27086 \| FOXP1 \| DISEASES 25970 \| SH2B1 \| DISEASES 1879 \| EBF1 \| DISEASES 161582 \| DYX1C1 \| DISEASES 1272 \| CNTN1 \| DISEASES 5663 \| PSEN1 \| DISEASES 1812 \| DRD1 \| DISEASES 83733 \| SLC25A18 \| DISEASES 9021 \| SOCS3 \| DISEASES 255324 \| EPGN \| DISEASES 6900 \| CNTN2 \| DISEASES 6938 \| TCF12 \| DISEASES 60529 \| ALX4 \| DISEASES 2558 \| GABRA5 \| DISEASES 80254 \| CEP63 \| DISEASES 57142 \| RTN4 \| DISEASES 23583 \| SMUG1 \| DISEASES 84239 \| ATP13A4 \| DISEASES 6575 \| SLC20A2 \| DISEASES 5493 \| PPL \| DISEASES 4137 \| MAPT \| DISEASES 84062 \| DTNBP1 \| DISEASES 1809 \| DPYSL3 \| DISEASES 875 \| CBS \| DISEASES 10019 \| SH2B3 \| DISEASES 1739 \| DLG1 \| DISEASES 1798 \| DPAGT1 \| DISEASES 4948 \| OCA2 \| DISEASES 23481 \| PES1 \| DISEASES 8654 \| PDE5A \| DISEASES 26503 \| SLC17A5 \| DISEASES 8310 \| ACOX3 \| DISEASES 57194 \| ATP10A \| DISEASES 1903 \| S1PR3 \| DISEASES 2571 \| GAD1 \| DISEASES 4763 \| NF1 \| DISEASES 3785 \| KCNQ2 \| DISEASES 617 \| BCS1L \| DISEASES 51150 \| SDF4 \| DISEASES 79947 \| DHDDS \| DISEASES 25894 \| PLEKHG4 \| DISEASES 1066 \| CES1 \| DISEASES 58484 \| NLRC4 \| DISEASES 477 \| ATP1A2 \| DISEASES 11214 \| AKAP13 \| DISEASES 26047 \| CNTNAP2 \| DISEASES 1813 \| DRD2 \| DISEASES 253738 \| EBF3 \| DISEASES 4184 \| SMCP \| DISEASES 54964 \| C1orf56 \| DISEASES 2332 \| FMR1 \| DISEASES 6658 \| SOX3 \| DISEASES 11128 \| POLR3A \| DISEASES 27286 \| SRPX2 \| DISEASES 64344 \| HIF3A \| DISEASES 9856 \| KIAA0319 \| DISEASES 2592 \| GALT \| DISEASES 170302 \| ARX \| DISEASES 6792 \| CDKL5 \| DISEASES 3704 \| ITPA \| DISEASES 265 \| AMELX \| DISEASES 10171 \| RCL1 \| DISEASES 1010 \| CDH12 \| DISEASES 2706 \| GJB2 \| DISEASES 10675 \| CSPG5 \| DISEASES 3786 \| KCNQ3 \| DISEASES 56953 \| NT5M \| DISEASES 9244 \| CRLF1 \| DISEASES 1621 \| DBH \| DISEASES 2132 \| EXT2 \| DISEASES 9306 \| SOCS6 \| DISEASES 6314 \| ATXN7 \| DISEASES 1607 \| DGKB \| DISEASES 3098 \| HK1 \| DISEASES 55120 \| FANCL \| DISEASES 55041 \| PLEKHB2 \| DISEASES 55777 \| MBD5 \| DISEASES 1052 \| CEBPD \| DISEASES 93986 \| FOXP2 \| DISEASES 57703 \| CWC22 \| DISEASES 3267 \| AGFG1 \| DISEASES 55636 \| CHD7 \| DISEASES 51317 \| PHF21A \| DISEASES 5334 \| PLCL1 \| DISEASES 9278 \| ZBTB22 \| DISEASES 5424 \| POLD1 \| DISEASES 54900 \| LAX1 \| DISEASES 22930 \| RAB3GAP1 \| DISEASES 389333 \| PROB1 \| DISEASES 6091 \| ROBO1 \| DISEASES 10687 \| PNMA2 \| DISEASES 57451 \| TENM2 \| DISEASES 83857 \| TMTC1 \| DISEASES 80790 \| CMIP \| DISEASES 283685 \| GOLGA6L2 \| DISEASES 820 \| CAMP \| DISEASES 104355217 \| ERICD \| DISEASES 102723508 \| KANTR \| DISEASES 103752588 \| PACERR \| DISEASES
Locus	(Waiting for update.)

Disease ID	1827
Disease	speech disorder
Integrated Phenotype	(Waiting for update.)
Text Mined Phenotype	HPO \| Name \| Sentences' Count(Total Phenotypes:16) HP:0000175 \| Palatoschisis \| 4 HP:0002381 \| Aphasia \| 3 HP:0000689 \| Misalignment of upper and lower dental arches \| 2 HP:0001260 \| Dysarthric speech \| 2 HP:0001250 \| Seizures \| 1 HP:0001067 \| Neurofibromas \| 1 HP:0012531 \| Pain \| 1 HP:0000365 \| Hearing impairment \| 1 HP:0001259 \| Coma \| 1 HP:0100021 \| Cerebral palsy \| 1 HP:0003690 \| Limb weakness \| 1 HP:0002539 \| Cortical dysplasia \| 1 HP:0003470 \| Inability to move \| 1 HP:0000964 \| Eczema \| 1 HP:0001251 \| Ataxia \| 1 HP:0100753 \| Schizophrenia \| 1

Disease ID	1827
Disease	speech disorder
Manually Symptom	(Waiting for update.)
Text Mined Symptom	(Waiting for update.)

Manually Genotype(Total Text Mining Genotypes:0)
(Waiting for update.)

All Snps(Total Genotypes:0)
(Waiting for update.)

GWASdb Annotation(Total Genotypes:0)
(Waiting for update.)

GWASdb Snp Trait(Total Genotypes:0)
(Waiting for update.)

Mapped by lexical matching(Total Items:0)
(Waiting for update.)

Mapped by homologous gene(Total Items:0)
(Waiting for update.)

Chemical(Total Drugs:22)
CUI	ChemicalName	ChemicalID	CasRN	DiseaseName	DiseaseID	DirectEvidence	PubMedIDs
C0037822	alprazolam	D000525	28981-97-7	speech disorders	MESH:D013064	marker/mechanism	19519270
C0037822	amitriptyline	D000639	50-48-6	speech disorders	MESH:D013064	marker/mechanism	717591
C0037822	carbamazepine	D002220	298-46-4	speech disorders	MESH:D013064	marker/mechanism	2492459
C0037822	cimetidine	D002927	51481-61-9	speech disorders	MESH:D013064	marker/mechanism	3777737
C0037822	citalopram	D015283	59729-33-8	speech disorders	MESH:D013064	marker/mechanism	19519270
C0037822	clozapine	D003024	5786-21-0	speech disorders	MESH:D013064	marker/mechanism	20578939
C0037822	erythromycin	D004917	114-07-8	speech disorders	MESH:D013064	marker/mechanism	8629881
C0037822	leucovorin	D002955	1958/5/9	speech disorders	MESH:D013064	therapeutic	6584197
C0037822	lidocaine	D008012	137-58-6	speech disorders	MESH:D013064	marker/mechanism	3563280
C0037822	lorazepam	D008140	846-49-1	speech disorders	MESH:D013064	marker/mechanism	2907315
C0037822	methadone	D008691	76-99-3	speech disorders	MESH:D013064	marker/mechanism	19808992
C0037822	dextromethorphan	D003915	125-71-3	speech disorders	MESH:D013064	marker/mechanism	21228393
C0037822	methotrexate	D008727	1959/5/2	speech disorders	MESH:D013064	marker/mechanism	11915742
C0037822	methylphenidate	D008774	113-45-1	speech disorders	MESH:D013064	marker/mechanism	1134893
C0037822	morphine	D009020	57-27-2	speech disorders	MESH:D013064	marker/mechanism	12351285
C0037822	olanzapine	C076029	132539-06-1	speech disorders	MESH:D013064	marker/mechanism	12611795
C0037822	phenytoin	D010672	57-41-0	speech disorders	MESH:D013064	marker/mechanism	11442446
C0037822	phenytoin	D010672	57-41-0	speech disorders	MESH:D013064	therapeutic	4406897
C0037822	prochlorperazine	D011346	58-38-8	speech disorders	MESH:D013064	marker/mechanism	20486582
C0037822	tacrolimus	D016559	109581-93-3	speech disorders	MESH:D013064	marker/mechanism	16573841
C0037822	thiethylperazine	D013847	1420-55-9	speech disorders	MESH:D013064	marker/mechanism	16101941
C0037822	valproic acid	D014635	99-66-1	speech disorders	MESH:D013064	marker/mechanism	16190799

FDA approved drug and dosage information(Total Drugs:0)
(Waiting for update.)

FDA labeling changes(Total Drugs:0)
(Waiting for update.)