PedAM

Pediatric Disease Annotations & Medicines


	smallpox

Disease ID	309
Disease	smallpox
Definition	An acute, highly contagious, often fatal infectious disease caused by an orthopoxvirus characterized by a biphasic febrile course and distinctive progressive skin eruptions. Vaccination has succeeded in eradicating smallpox worldwide. (Dorland, 28th ed)
Synonym	classical smallpox ordinary smallpox smallpox (disorder) smallpox [disease/finding] smallpox disease smallpox nos smallpox nos (disorder) smallpox, nos smallpox, unspecified variola variola major variola, nos variolas
DOID	DOID:8736 DOID:0050508
ICD10	ICD10CM:B03
UMLS	C0037354
MeSH	D012899
SNOMED-CT	SNOMEDCT_US_2016_09_01:67924001
Comorbidity	UMLS \| Disease \| Sentences' Count(Total Sentences:17) C0042214 \| vaccinia \| 11 C0010232 \| cowpox \| 2 C0037354 \| variola \| 2 C0011603 \| dermatitis \| 2 C0037354 \| smallpox \| 2 C0008049 \| varicella \| 1 C0032914 \| toxemia \| 1 C0009763 \| conjunctivitis \| 1 C0041296 \| tuberculosis \| 1 C0040034 \| thrombocytopenia \| 1 C0006142 \| breast cancer \| 1 C0085110 \| severe combined immunodefic \| 1 C0042769 \| virus infection \| 1 C0006285 \| bronchopneumonia \| 1 C0027059 \| myocarditis \| 1 C0011615 \| atopic dermatitis \| 1 C0032285 \| pneumonitis \| 1
Curated Gene	(Waiting for update.)
Inferring Gene	(Waiting for update.)
Text Mined Gene	Entrez_id \| Symbol \| Score \| Resource(Total Genes:176) 2288 \| FKBP4 \| DISEASES 7132 \| TNFRSF1A \| DISEASES 3566 \| IL4R \| DISEASES 2802 \| GOLGA3 \| DISEASES 25776 \| CBY1 \| DISEASES 3560 \| IL2RB \| DISEASES 3002 \| GZMB \| DISEASES 51311 \| TLR8 \| DISEASES 2137 \| EXTL3 \| DISEASES 5971 \| RELB \| DISEASES 8976 \| WASL \| DISEASES 944 \| TNFSF8 \| DISEASES 79176 \| FBXL15 \| DISEASES 6348 \| CCL3 \| DISEASES 6348 \| CCL3 \| DISEASES 3558 \| IL2 \| DISEASES 3558 \| IL2 \| DISEASES 3458 \| IFNG \| DISEASES 3458 \| IFNG \| DISEASES 3003 \| GZMK \| DISEASES 4012 \| LNPEP \| DISEASES 3565 \| IL4 \| DISEASES 6500 \| SKP1 \| DISEASES 8809 \| IL18R1 \| DISEASES 64895 \| PAPOLG \| DISEASES 2703 \| GJA8 \| DISEASES 7374 \| UNG \| DISEASES 3659 \| IRF1 \| DISEASES 718 \| C3 \| DISEASES 7429 \| VIL1 \| DISEASES 7425 \| VGF \| DISEASES 6351 \| CCL4 \| DISEASES 51132 \| RLIM \| DISEASES 1965 \| EIF2S1 \| DISEASES 3656 \| IRAK2 \| DISEASES 8638 \| OASL \| DISEASES 10068 \| IL18BP \| DISEASES 10017 \| BCL2L10 \| DISEASES 3595 \| IL12RB2 \| DISEASES 5588 \| PRKCQ \| DISEASES 3553 \| IL1B \| DISEASES 10578 \| GNLY \| DISEASES 943 \| TNFRSF8 \| DISEASES 867 \| CBL \| DISEASES 4811 \| NID1 \| DISEASES 54464 \| XRN1 \| DISEASES 1950 \| EGF \| DISEASES 55749 \| CCAR1 \| DISEASES 939 \| CD27 \| DISEASES 1039 \| CDR2 \| DISEASES 3454 \| IFNAR1 \| DISEASES 6282 \| S100A11 \| DISEASES 51542 \| VPS54 \| DISEASES 3001 \| GZMA \| DISEASES 5921 \| RASA1 \| DISEASES 5331 \| PLCB3 \| DISEASES 738 \| VPS51 \| DISEASES 3606 \| IL18 \| DISEASES 2180 \| ACSL1 \| DISEASES 83439 \| TCF7L1 \| DISEASES 221458 \| KIF6 \| DISEASES 4690 \| NCK1 \| DISEASES 3588 \| IL10RB \| DISEASES 1234 \| CCR5 \| DISEASES 10898 \| CPSF4 \| DISEASES 6352 \| CCL5 \| DISEASES 362 \| AQP5 \| DISEASES 5937 \| RBMS1 \| DISEASES 152185 \| SPICE1 \| DISEASES 8820 \| HESX1 \| DISEASES 7098 \| TLR3 \| DISEASES 7098 \| TLR3 \| DISEASES 1437 \| CSF2 \| DISEASES 1672 \| DEFB1 \| DISEASES 81501 \| DCSTAMP \| DISEASES 115825 \| WDFY2 \| DISEASES 6236 \| RRAD \| DISEASES 929 \| CD14 \| DISEASES 1841 \| DTYMK \| DISEASES 3596 \| IL13 \| DISEASES 3627 \| CXCL10 \| DISEASES 1128 \| CHRM1 \| DISEASES 81793 \| TLR10 \| DISEASES 3661 \| IRF3 \| DISEASES 7681 \| MKRN3 \| DISEASES 22882 \| ZHX2 \| DISEASES 7334 \| UBE2N \| DISEASES 1960 \| EGR3 \| DISEASES 64388 \| GREM2 \| DISEASES 6470 \| SHMT1 \| DISEASES 10938 \| EHD1 \| DISEASES 25898 \| RCHY1 \| DISEASES 149830 \| PRNT \| DISEASES 149830 \| PRNT \| DISEASES 8454 \| CUL1 \| DISEASES 706 \| TSPO \| DISEASES 3665 \| IRF7 \| DISEASES 9939 \| RBM8A \| DISEASES 3916 \| LAMP1 \| DISEASES 4600 \| MX2 \| DISEASES 5873 \| RAB27A \| DISEASES 1981 \| EIF4G1 \| DISEASES 3824 \| KLRD1 \| DISEASES 7335 \| UBE2V1 \| DISEASES 4076 \| CAPRIN1 \| DISEASES 10146 \| G3BP1 \| DISEASES 6231 \| RPS26 \| DISEASES 5625 \| PRODH \| DISEASES 3663 \| IRF5 \| DISEASES 23141 \| ANKLE2 \| DISEASES 404552 \| SCGB1D4 \| DISEASES 6364 \| CCL20 \| DISEASES 7415 \| VCP \| DISEASES 3821 \| KLRC1 \| DISEASES 54106 \| TLR9 \| DISEASES 58484 \| NLRC4 \| DISEASES 6772 \| STAT1 \| DISEASES 1727 \| CYB5R3 \| DISEASES 4283 \| CXCL9 \| DISEASES 65217 \| PCDH15 \| DISEASES 2987 \| GUK1 \| DISEASES 1805 \| DPT \| DISEASES 55811 \| ADCY10 \| DISEASES 9191 \| DEDD \| DISEASES 912 \| CD1D \| DISEASES 2312 \| FLG \| DISEASES 284486 \| THEM5 \| DISEASES 1755 \| DMBT1 \| DISEASES 8945 \| BTRC \| DISEASES 1369 \| CPN1 \| DISEASES 959 \| CD40LG \| DISEASES 7099 \| TLR4 \| DISEASES 283078 \| MKX \| DISEASES 57512 \| GPR158 \| DISEASES 3980 \| LIG3 \| DISEASES 9445 \| ITM2B \| DISEASES 146 \| ADRA1D \| DISEASES 3456 \| IFNB1 \| DISEASES 51284 \| TLR7 \| DISEASES 2315 \| MLANA \| DISEASES 3823 \| KLRC3 \| DISEASES 10333 \| TLR6 \| DISEASES 4285 \| MIPEP \| DISEASES 3161 \| HMMR \| DISEASES 9560 \| CCL4L2 \| DISEASES 3965 \| LGALS9 \| DISEASES 4599 \| MX1 \| DISEASES 7322 \| UBE2D2 \| DISEASES 56907 \| SPIRE1 \| DISEASES 3447 \| IFNA13 \| DISEASES 7124 \| TNF \| DISEASES 3106 \| HLA-B \| DISEASES 4615 \| MYD88 \| DISEASES 57506 \| MAVS \| DISEASES 8831 \| SYNGAP1 \| DISEASES 388372 \| CCL4L1 \| DISEASES 79827 \| CLMP \| DISEASES 6293 \| VPS52 \| DISEASES 4050 \| LTB \| DISEASES 3586 \| IL10 \| DISEASES 721 \| C4B \| DISEASES 6256 \| RXRA \| DISEASES 30816 \| ERVW-1 \| DISEASES 51428 \| DDX41 \| DISEASES 27071 \| DAPP1 \| DISEASES 11275 \| KLHL2 \| DISEASES 51399 \| TRAPPC4 \| DISEASES 64478 \| CSMD1 \| DISEASES 8972 \| MGAM \| DISEASES 84525 \| HOPX \| DISEASES 387521 \| TMEM189 \| DISEASES 8742 \| TNFSF12 \| DISEASES 820 \| CAMP \| DISEASES 2323 \| FLT3LG \| DISEASES 7409 \| VAV1 \| DISEASES 10108 \| MKRN3-AS1 \| DISEASES
Locus	(Waiting for update.)

Disease ID	309
Disease	smallpox
Integrated Phenotype	(Waiting for update.)
Text Mined Phenotype	HPO \| Name \| Sentences' Count(Total Phenotypes:5) HP:0001047 \| Atopic dermatitis \| 1 HP:0001873 \| Low platelet count \| 1 HP:0012819 \| Myocarditis \| 1 HP:0003002 \| Breast carcinoma \| 1 HP:0000509 \| Conjunctivitis \| 1

Disease ID	309
Disease	smallpox
Manually Symptom	UMLS \| Name(Total Manually Symptoms:24) C1963137 \| hydrocephalus C1611280 \| allergy C0854532 \| myopericarditis C0374992 \| mycoplasma C0275522 \| subclinical infection C0275522 \| inapparent infection C0264523 \| pulmonary calcification C0262984 \| spongiotic dermatitis C0205721 \| nosocomial infection C0042749 \| viraemia C0042740 \| viral syndrome C0042216 \| vaccinia C0039128 \| syphilis C0037285 \| skin manifestations C0037284 \| skin lesions C0034152 \| anaphylactoid purpura C0025202 \| malignant melanomas C0025010 \| measles C0019087 \| hemorrhagic diathesis C0015230 \| rash C0014038 \| encephalitis C0007117 \| basal cell epithelioma C0007114 \| skin cancer C0003864 \| arthritis
Text Mined Symptom	UMLS \| Name \| Sentences' Count(Total Symptoms:1) C0042214 \| vaccinia \| 10

Manually Genotype(Total Text Mining Genotypes:0)
(Waiting for update.)

All Snps(Total Genotypes:0)
(Waiting for update.)

GWASdb Annotation(Total Genotypes:0)
(Waiting for update.)

GWASdb Snp Trait(Total Genotypes:168)
CHR	POS	SNPID	REF	ALT	ORI_SNPID	PMID	P_VALUE	P_VALUE_TEXT	OR/BETA	CI95_TEXT	GWAS_INITIAL_SAMPLE_SIZE	SUB_POPULATION	SUPER_POPULATION	GWAS_TRAIT	HPO_ID	HPO_TERM	DO_ID	DO_TERM	MESH_ID	MESH_TERM	EFO_ID	EFO_TERM	DOLITE_TERM	RISK_ALLELE	PUBLICATION_TYPE	AA	GENE_SYMBOL	TYPE	REFGENE
1	20518226	rs3179690	G	A	rs3179690	22661280	3.11E-08	NA	NA	NA	537 European ancestry individuals; 207 African American individuals	African American(207)	European(537)	ALL(744)	AFR(207)	EUR(537)	ALL(744)	Secreted IFN-gamma response to smallpox vaccine	HPOID:0005368	Abnormality of humoral immunity	DOID:8736	smallpox	NA	NA	NA	NA	Virus disease	NA	Research Support, N.I.H., Extramural
1	22373624	rs2501276	C	T	rs2501276	22610502	2.00E-07	NA	NA	NA	Up to 512 European ancestry individuals; 199 African American individuals	African American(199)	European(512)	ALL(711)	AFR(199)	EUR(512)	ALL(711)	Immune response to smallpox vaccine (IL-6)	HPOID:0005368	Abnormality of humoral immunity	DOID:8736	smallpox	D012899	Smallpox	EFOID:0004873	response to vaccine	Virus disease	rs2501276-A	Research Support, N.I.H., Extramural
1	58367236	rs6679454	A	G	rs6679454	22610502	3.00E-07	NA	NA	NA	Up to 512 European ancestry individuals; up to 199 African American individuals	African American(199)	European(512)	ALL(711)	AFR(199)	EUR(512)	ALL(711)	Immune reponse to smallpox (secreted IL-10)	HPOID:0005368	Abnormality of humoral immunity	DOID:8736	smallpox	D012899	Smallpox	EFOID:0004645	cytokine measurement	Virus disease	rs6679454-G	Research Support, N.I.H., Extramural
1	69894849	rs11209457	G	A	rs11209457	22661280	0.000000485	NA	NA	NA	537 European ancestry individuals; 207 African American individuals	African American(207)	European(537)	ALL(744)	AFR(207)	EUR(537)	ALL(744)	Secreted IFN-gamma response to smallpox vaccine	HPOID:0005368	Abnormality of humoral immunity	DOID:8736	smallpox	NA	NA	NA	NA	Virus disease	NA	Research Support, N.I.H., Extramural
1	111033809	rs4839431	T	C	rs4839431	22610502	2.00E-07	NA	NA	NA	Up to 512 European ancestry individuals; up to 199 African American individuals	African American(199)	European(512)	ALL(711)	AFR(199)	EUR(512)	ALL(711)	Immune reponse to smallpox (secreted IFN-alpha)	HPOID:0005368	Abnormality of humoral immunity	DOID:8736	smallpox	D012899	Smallpox	EFOID:0004873	response to vaccine	Virus disease	rs4839431-A	Research Support, N.I.H., Extramural
1	112392360	rs12044963	G	T	rs12044963	22610502	9.00E-10	AA	NA	NA	Up to 512 European ancestry individuals; up to 199 African American individuals	African American(199)	European(512)	ALL(711)	AFR(199)	EUR(512)	ALL(711)	Immune reponse to smallpox (secreted IFN-alpha)	HPOID:0005368	Abnormality of humoral immunity	DOID:8736	smallpox	D012899	Smallpox	EFOID:0004873	response to vaccine	Virus disease	rs12044963-A	Research Support, N.I.H., Extramural
1	178142208	rs316274	G	A	rs316274	22542470	8.00E-07	NA	NA	NA	217 African American ancestry individuals; 580 European ancestry individuals; 217 Hispanic ancestry individuals	European(580)	African American(217)	Hispanic(217)	ALL(1014)	HIS(217)	AFR(217)	EUR(580)	ALL(1014)	Immune response to smallpox vaccine (IL-6)	HPOID:0005368	Abnormality of humoral immunity	DOID:8736	smallpox	D012899	Smallpox	EFOID:0004873	response to vaccine	Virus disease
1	189589339	rs10489759	C	T	rs10489759	22542470	8.00E-08	NA	NA	NA	217 African American ancestry individuals; 580 European ancestry individuals; 217 Hispanic ancestry individuals	European(580)	African American(217)	Hispanic(217)	ALL(1014)	HIS(217)	AFR(217)	EUR(580)	ALL(1014)	Immune response to smallpox vaccine (IL-6)	HPOID:0005368	Abnormality of humoral immunity	DOID:8736	smallpox	D012899	Smallpox	EFOID:0004873	response to vaccine	Virus disease
1	235092600	rs908327	A	C	rs908327	22610502	5.00E-10	AA	NA	NA	Up to 512 European ancestry individuals; up to 199 African American individuals	African American(199)	European(512)	ALL(711)	AFR(199)	EUR(512)	ALL(711)	Immune reponse to smallpox (secreted IL-2)	HPOID:0005368	Abnormality of humoral immunity	DOID:8736	smallpox	D012899	Smallpox	EFOID:0004645	cytokine measurement	Virus disease	rs908327-C	Research Support, N.I.H., Extramural
1	240706107	rs10495471	A	G	rs10495471	22542470	2.00E-07	NA	NA	NA	217 African American ancestry individuals; 580 European ancestry individuals; 217 Hispanic ancestry individuals	European(580)	African American(217)	Hispanic(217)	ALL(1014)	HIS(217)	AFR(217)	EUR(580)	ALL(1014)	Immune response to smallpox vaccine (IL-6)	HPOID:0005368	Abnormality of humoral immunity	DOID:8736	smallpox	D012899	Smallpox	EFOID:0004873	response to vaccine	Virus disease
2	26272602	rs13388915	G	A	rs13388915	22542470	8.00E-06	NA	NA	NA	217 African American ancestry individuals; 580 European ancestry individuals; 217 Hispanic ancestry individuals	European(580)	African American(217)	Hispanic(217)	ALL(1014)	HIS(217)	AFR(217)	EUR(580)	ALL(1014)	Immune response to smallpox vaccine (IL-6)	HPOID:0005368	Abnormality of humoral immunity	DOID:8736	smallpox	D012899	Smallpox	EFOID:0004873	response to vaccine	Virus disease
2	33121504	rs6728021	A	G	rs6728021	22610502	4.00E-08	NA	NA	NA	Up to 512 European ancestry individuals; 199 African American individuals	African American(199)	European(512)	ALL(711)	AFR(199)	EUR(512)	ALL(711)	Immune response to smallpox vaccine (IL-6)	HPOID:0005368	Abnormality of humoral immunity	DOID:8736	smallpox	D012899	Smallpox	EFOID:0004873	response to vaccine	Virus disease	rs6728021-G	Research Support, N.I.H., Extramural
2	33301947	rs542631	T	G	rs542631	22610502	1.00E-07	NA	NA	NA	Up to 512 European ancestry individuals; up to 199 African American individuals	African American(199)	European(512)	ALL(711)	AFR(199)	EUR(512)	ALL(711)	Immune reponse to smallpox (secreted IFN-alpha)	HPOID:0005368	Abnormality of humoral immunity	DOID:8736	smallpox	D012899	Smallpox	EFOID:0004873	response to vaccine	Virus disease	rs542631-A	Research Support, N.I.H., Extramural
2	44662475	rs13414205	C	T	rs13414205	22610502	7.00E-08	NA	NA	NA	Up to 512 European ancestry individuals; up to 199 African American individuals	African American(199)	European(512)	ALL(711)	AFR(199)	EUR(512)	ALL(711)	Immune reponse to smallpox (secreted TNF-alpha)	HPOID:0005368	Abnormality of humoral immunity	DOID:8736	smallpox	D012899	Smallpox	EFOID:0004645	cytokine measurement	Virus disease	rs13414205-A	Research Support, N.I.H., Extramural
2	68359897	rs4078978	C	T	rs4078978	22610502	2.00E-18	AA	NA	NA	Up to 512 European ancestry individuals; up to 199 African American individuals	African American(199)	European(512)	ALL(711)	AFR(199)	EUR(512)	ALL(711)	Immune reponse to smallpox (secreted IFN-alpha)	HPOID:0005368	Abnormality of humoral immunity	DOID:8736	smallpox	D012899	Smallpox	EFOID:0004873	response to vaccine	Virus disease	rs4078978-A	Research Support, N.I.H., Extramural
2	74463566	rs13006863	C	T	rs13006863	22610502	5.00E-07	NA	NA	NA	Up to 512 European ancestry individuals; up to 199 African American individuals	African American(199)	European(512)	ALL(711)	AFR(199)	EUR(512)	ALL(711)	Immune reponse to smallpox (secreted TNF-alpha)	HPOID:0005368	Abnormality of humoral immunity	DOID:8736	smallpox	D012899	Smallpox	EFOID:0004645	cytokine measurement	Virus disease	rs13006863-A	Research Support, N.I.H., Extramural
2	85524369	rs6737773	A	G	rs6737773	22661280	4.27E-08	NA	NA	NA	537 European ancestry individuals; 207 African American individuals	African American(207)	European(537)	ALL(744)	AFR(207)	EUR(537)	ALL(744)	CD8+ T cell IFN-gamma response to smallpox vaccine	HPOID:0005368	Abnormality of humoral immunity	DOID:8736	smallpox	NA	NA	NA	NA	Virus disease	NA	Research Support, N.I.H., Extramural
2	123225623	rs17007761	C	A	rs17007761	22610502	1.00E-08	NA	NA	NA	Up to 512 European ancestry individuals; up to 199 African American individuals	African American(199)	European(512)	ALL(711)	AFR(199)	EUR(512)	ALL(711)	Immune reponse to smallpox (secreted IFN-alpha)	HPOID:0005368	Abnormality of humoral immunity	DOID:8736	smallpox	D012899	Smallpox	EFOID:0004873	response to vaccine	Virus disease	rs17007761-A	Research Support, N.I.H., Extramural
2	150147278	rs10432496	C	T	rs10432496	22610502	6.00E-08	NA	NA	NA	Up to 512 European ancestry individuals; up to 199 African American individuals	African American(199)	European(512)	ALL(711)	AFR(199)	EUR(512)	ALL(711)	Immune reponse to smallpox (secreted IL-2)	HPOID:0005368	Abnormality of humoral immunity	DOID:8736	smallpox	D012899	Smallpox	EFOID:0004645	cytokine measurement	Virus disease	rs10432496-A	Research Support, N.I.H., Extramural
2	151725792	rs10195263	G	A	rs10195263	22610502	3.00E-08	NA	NA	NA	Up to 512 European ancestry individuals; up to 199 African American individuals	African American(199)	European(512)	ALL(711)	AFR(199)	EUR(512)	ALL(711)	Immune reponse to smallpox (secreted IFN-alpha)	HPOID:0005368	Abnormality of humoral immunity	DOID:8736	smallpox	D012899	Smallpox	EFOID:0004873	response to vaccine	Virus disease	rs10195263-G	Research Support, N.I.H., Extramural
2	177511440	rs16864122	C	T	rs16864122	22661280	0.000000252	NA	NA	NA	537 European ancestry individuals; 207 African American individuals	African American(207)	European(537)	ALL(744)	AFR(207)	EUR(537)	ALL(744)	CD8+ T cell IFN-gamma response to smallpox vaccine	HPOID:0005368	Abnormality of humoral immunity	DOID:8736	smallpox	NA	NA	NA	NA	Virus disease	NA	Research Support, N.I.H., Extramural
2	219840891	rs359965	G	A	rs359965	22542470	2.00E-06	NA	NA	NA	217 African American ancestry individuals; 580 European ancestry individuals; 217 Hispanic ancestry individuals	European(580)	African American(217)	Hispanic(217)	ALL(1014)	HIS(217)	AFR(217)	EUR(580)	ALL(1014)	Immune response to smallpox vaccine (IL-6)	HPOID:0005368	Abnormality of humoral immunity	DOID:8736	smallpox	D012899	Smallpox	EFOID:0004873	response to vaccine	Virus disease
2	227915924	rs2272205	T	C	rs2272205	22610502	3.00E-09	NA	NA	NA	Up to 512 European ancestry individuals; up to 199 African American individuals	African American(199)	European(512)	ALL(711)	AFR(199)	EUR(512)	ALL(711)	Immune reponse to smallpox (secreted IFN-alpha)	HPOID:0005368	Abnormality of humoral immunity	DOID:8736	smallpox	D012899	Smallpox	EFOID:0004873	response to vaccine	Virus disease	rs2272205-G	Research Support, N.I.H., Extramural
2	228481419	rs11889798	C	T	rs11889798	22610502	4.00E-07	NA	NA	NA	Up to 512 European ancestry individuals; up to 199 African American individuals	African American(199)	European(512)	ALL(711)	AFR(199)	EUR(512)	ALL(711)	Immune reponse to smallpox (secreted TNF-alpha)	HPOID:0005368	Abnormality of humoral immunity	DOID:8736	smallpox	D012899	Smallpox	EFOID:0004645	cytokine measurement	Virus disease	rs11889798-A	Research Support, N.I.H., Extramural
2	232624863	rs4973479	C	T	rs4973479	22661280	0.000000315	NA	NA	NA	537 European ancestry individuals; 207 African American individuals	African American(207)	European(537)	ALL(744)	AFR(207)	EUR(537)	ALL(744)	Total IFN-gamma response to smallpox vaccine	HPOID:0005368	Abnormality of humoral immunity	DOID:8736	smallpox	NA	NA	NA	NA	Virus disease	NA	Research Support, N.I.H., Extramural
3	3130645	rs3804795	T	C	rs3804795	22542470	1.00E-06	NA	NA	NA	217 African American ancestry individuals; 580 European ancestry individuals; 217 Hispanic ancestry individuals	European(580)	African American(217)	Hispanic(217)	ALL(1014)	HIS(217)	AFR(217)	EUR(580)	ALL(1014)	Immune response to smallpox vaccine (IL-6)	HPOID:0005368	Abnormality of humoral immunity	DOID:8736	smallpox	D012899	Smallpox	EFOID:0004873	response to vaccine	Virus disease
3	3375784	rs9835812	G	T	rs9835812	22542470	8.00E-07	NA	NA	NA	217 African American ancestry individuals; 580 European ancestry individuals; 217 Hispanic ancestry individuals	European(580)	African American(217)	Hispanic(217)	ALL(1014)	HIS(217)	AFR(217)	EUR(580)	ALL(1014)	Immune response to smallpox vaccine (IL-6)	HPOID:0005368	Abnormality of humoral immunity	DOID:8736	smallpox	D012899	Smallpox	EFOID:0004873	response to vaccine	Virus disease
3	45817418	rs758386	A	G	rs758386	22610502	2.00E-07	NA	NA	NA	Up to 512 European ancestry individuals; up to 199 African American individuals	African American(199)	European(512)	ALL(711)	AFR(199)	EUR(512)	ALL(711)	Immune reponse to smallpox (secreted TNF-alpha)	HPOID:0005368	Abnormality of humoral immunity	DOID:8736	smallpox	D012899	Smallpox	EFOID:0004645	cytokine measurement	Virus disease	rs758386-A	Research Support, N.I.H., Extramural
3	52844534	rs17331151	C	T	rs17331151	22610502	2.00E-09	NA	NA	NA	Up to 512 European ancestry individuals; up to 199 African American individuals	African American(199)	European(512)	ALL(711)	AFR(199)	EUR(512)	ALL(711)	Immune reponse to smallpox (secreted IL-2)	HPOID:0005368	Abnormality of humoral immunity	DOID:8736	smallpox	D012899	Smallpox	EFOID:0004645	cytokine measurement	Virus disease	rs17331151-A	Research Support, N.I.H., Extramural
3	52913279	rs3796352	C	T	rs3796352	22610502	5.00E-07	NA	NA	NA	Up to 512 European ancestry individuals; up to 199 African American individuals	African American(199)	European(512)	ALL(711)	AFR(199)	EUR(512)	ALL(711)	Immune reponse to smallpox (secreted IL-2)	HPOID:0005368	Abnormality of humoral immunity	DOID:8736	smallpox	D012899	Smallpox	EFOID:0004645	cytokine measurement	Virus disease	rs3796352-A	Research Support, N.I.H., Extramural
3	53147576	rs13088281	C	A	rs13088281	22610502	3.00E-11	AA	NA	NA	Up to 512 European ancestry individuals; up to 199 African American individuals	African American(199)	European(512)	ALL(711)	AFR(199)	EUR(512)	ALL(711)	Immune reponse to smallpox (secreted IL-2)	HPOID:0005368	Abnormality of humoral immunity	DOID:8736	smallpox	D012899	Smallpox	EFOID:0004645	cytokine measurement	Virus disease	rs13088281-A	Research Support, N.I.H., Extramural
3	55035874	rs4955826	C	T	rs4955826	22542470	5.00E-06	NA	NA	NA	217 African American ancestry individuals; 580 European ancestry individuals; 217 Hispanic ancestry individuals	European(580)	African American(217)	Hispanic(217)	ALL(1014)	HIS(217)	AFR(217)	EUR(580)	ALL(1014)	Immune response to smallpox vaccine (IL-6)	HPOID:0005368	Abnormality of humoral immunity	DOID:8736	smallpox	D012899	Smallpox	EFOID:0004873	response to vaccine	Virus disease
3	133589324	rs9835973	C	T	rs9835973	22610502	7.00E-08	NA	NA	NA	Up to 512 European ancestry individuals; up to 199 African American individuals	African American(199)	European(512)	ALL(711)	AFR(199)	EUR(512)	ALL(711)	Immune reponse to smallpox (secreted IL-1beta)	HPOID:0005368	Abnormality of humoral immunity	DOID:8736	smallpox	D012899	Smallpox	EFOID:0004645	cytokine measurement	Virus disease	rs9835973-A	Research Support, N.I.H., Extramural
3	152535365	rs10513432	T	C	rs10513432	22610502	4.00E-07	NA	NA	NA	Up to 512 European ancestry individuals; up to 199 African American individuals	African American(199)	European(512)	ALL(711)	AFR(199)	EUR(512)	ALL(711)	Immune reponse to smallpox (secreted IL-2)	HPOID:0005368	Abnormality of humoral immunity	DOID:8736	smallpox	D012899	Smallpox	EFOID:0004645	cytokine measurement	Virus disease	rs10513432-G	Research Support, N.I.H., Extramural
3	153184656	rs6778194	A	C	rs6778194	22610502	2.00E-09	NA	NA	NA	Up to 512 European ancestry individuals; up to 199 African American individuals	African American(199)	European(512)	ALL(711)	AFR(199)	EUR(512)	ALL(711)	Immune reponse to smallpox (secreted IFN-alpha)	HPOID:0005368	Abnormality of humoral immunity	DOID:8736	smallpox	D012899	Smallpox	EFOID:0004873	response to vaccine	Virus disease	rs6778194-C	Research Support, N.I.H., Extramural
3	169080185	rs9883650	T	G	rs9883650	22610502	4.00E-07	NA	NA	NA	Up to 512 European ancestry individuals; up to 199 African American individuals	African American(199)	European(512)	ALL(711)	AFR(199)	EUR(512)	ALL(711)	Immune reponse to smallpox (secreted IL-1beta)	HPOID:0005368	Abnormality of humoral immunity	DOID:8736	smallpox	D012899	Smallpox	EFOID:0004645	cytokine measurement	Virus disease	rs9883650-C	Research Support, N.I.H., Extramural
3	188584679	rs13067593	A	G	rs13067593	22610502	8.00E-08	NA	NA	NA	Up to 512 European ancestry individuals; up to 199 African American individuals	African American(199)	European(512)	ALL(711)	AFR(199)	EUR(512)	ALL(711)	Immune reponse to smallpox (secreted IFN-alpha)	HPOID:0005368	Abnormality of humoral immunity	DOID:8736	smallpox	D012899	Smallpox	EFOID:0004873	response to vaccine	Virus disease	rs13067593-G	Research Support, N.I.H., Extramural
3	191521852	rs1516489	A	C	rs1516489	22610502	8.00E-08	NA	NA	NA	Up to 512 European ancestry individuals; 199 African American individuals	African American(199)	European(512)	ALL(711)	AFR(199)	EUR(512)	ALL(711)	Immune response to smallpox vaccine (IL-6)	HPOID:0005368	Abnormality of humoral immunity	DOID:8736	smallpox	D012899	Smallpox	EFOID:0004873	response to vaccine	Virus disease	rs1516489-C	Research Support, N.I.H., Extramural
4	282499	rs11723261	A	G	rs11723261	22542470	4.00E-06	NA	NA	NA	217 African American ancestry individuals; 580 European ancestry individuals; 217 Hispanic ancestry individuals	European(580)	African American(217)	Hispanic(217)	ALL(1014)	HIS(217)	AFR(217)	EUR(580)	ALL(1014)	Immune response to smallpox vaccine (IL-6)	HPOID:0005368	Abnormality of humoral immunity	DOID:8736	smallpox	D012899	Smallpox	EFOID:0004873	response to vaccine	Virus disease
4	16940391	rs16894201	G	T	rs16894201	22661280	0.000000145	NA	NA	NA	537 European ancestry individuals; 207 African American individuals	African American(207)	European(537)	ALL(744)	AFR(207)	EUR(537)	ALL(744)	CD8+ T cell IFN-gamma response to smallpox vaccine	HPOID:0005368	Abnormality of humoral immunity	DOID:8736	smallpox	NA	NA	NA	NA	Virus disease	NA	Research Support, N.I.H., Extramural
4	28489837	rs16880706	T	C	rs16880706	22661280	0.000000354	NA	NA	NA	537 European ancestry individuals; 207 African American individuals	African American(207)	European(537)	ALL(744)	AFR(207)	EUR(537)	ALL(744)	CD8+ T cell IFN-gamma response to smallpox vaccine	HPOID:0005368	Abnormality of humoral immunity	DOID:8736	smallpox	NA	NA	NA	NA	Virus disease	NA	Research Support, N.I.H., Extramural
4	42453253	rs10517025	C	T	rs10517025	22610502	2.00E-07	NA	NA	NA	Up to 512 European ancestry individuals; up to 199 African American individuals	African American(199)	European(512)	ALL(711)	AFR(199)	EUR(512)	ALL(711)	Immune reponse to smallpox (secreted IFN-alpha)	HPOID:0005368	Abnormality of humoral immunity	DOID:8736	smallpox	D012899	Smallpox	EFOID:0004873	response to vaccine	Virus disease	rs10517025-A	Research Support, N.I.H., Extramural
4	75160824	rs16850864	C	T	rs16850864	22610502	7.00E-09	NA	NA	NA	Up to 512 European ancestry individuals; up to 199 African American individuals	African American(199)	European(512)	ALL(711)	AFR(199)	EUR(512)	ALL(711)	Immune reponse to smallpox (secreted IL-1beta)	HPOID:0005368	Abnormality of humoral immunity	DOID:8736	smallpox	D012899	Smallpox	EFOID:0004645	cytokine measurement	Virus disease	rs16850864-A	Research Support, N.I.H., Extramural
4	75170140	rs16850885	G	A	rs16850885	22610502	7.00E-09	NA	NA	NA	Up to 512 European ancestry individuals; up to 199 African American individuals	African American(199)	European(512)	ALL(711)	AFR(199)	EUR(512)	ALL(711)	Immune reponse to smallpox (secreted IL-1beta)	HPOID:0005368	Abnormality of humoral immunity	DOID:8736	smallpox	D012899	Smallpox	EFOID:0004645	cytokine measurement	Virus disease	rs16850885-A	Research Support, N.I.H., Extramural
4	77889994	rs2645668	T	C	rs2645668	22661280	7.25E-08	NA	NA	NA	537 European ancestry individuals; 207 African American individuals	African American(207)	European(537)	ALL(744)	AFR(207)	EUR(537)	ALL(744)	CD8+ T cell IFN-gamma response to smallpox vaccine	HPOID:0005368	Abnormality of humoral immunity	DOID:8736	smallpox	NA	NA	NA	NA	Virus disease	NA	Research Support, N.I.H., Extramural
4	146853165	rs2048161	A	G	rs2048161	22610502	6.00E-12	AA	NA	NA	Up to 512 European ancestry individuals; up to 199 African American individuals	African American(199)	European(512)	ALL(711)	AFR(199)	EUR(512)	ALL(711)	Immune reponse to smallpox (secreted IFN-alpha)	HPOID:0005368	Abnormality of humoral immunity	DOID:8736	smallpox	D012899	Smallpox	EFOID:0004873	response to vaccine	Virus disease	rs2048161-A	Research Support, N.I.H., Extramural
4	148884189	rs7658486	C	T	rs7658486	22610502	1.00E-08	NA	NA	NA	Up to 512 European ancestry individuals; up to 199 African American individuals	African American(199)	European(512)	ALL(711)	AFR(199)	EUR(512)	ALL(711)	Immune reponse to smallpox (secreted IL-12p40)	HPOID:0005368	Abnormality of humoral immunity	DOID:8736	smallpox	D012899	Smallpox	EFOID:0004873	response to vaccine	Virus disease	rs7658486-A	Research Support, N.I.H., Extramural
4	155316122	rs902464	T	C	rs902464	22610502	3.00E-07	NA	NA	NA	Up to 512 European ancestry individuals; up to 199 African American individuals	African American(199)	European(512)	ALL(711)	AFR(199)	EUR(512)	ALL(711)	Immune reponse to smallpox (secreted IL-1beta)	HPOID:0005368	Abnormality of humoral immunity	DOID:8736	smallpox	D012899	Smallpox	EFOID:0004645	cytokine measurement	Virus disease	rs902464-A	Research Support, N.I.H., Extramural
4	168264249	rs13111850	C	T	rs13111850	22610502	3.00E-11	AA	NA	NA	Up to 512 European ancestry individuals; up to 199 African American individuals	African American(199)	European(512)	ALL(711)	AFR(199)	EUR(512)	ALL(711)	Immune reponse to smallpox (secreted IL-10)	HPOID:0005368	Abnormality of humoral immunity	DOID:8736	smallpox	D012899	Smallpox	EFOID:0004645	cytokine measurement	Virus disease	rs13111850-G	Research Support, N.I.H., Extramural
4	184305340	rs1588571	T	C	rs1588571	22661280	0.000000492	NA	NA	NA	537 European ancestry individuals; 207 African American individuals	African American(207)	European(537)	ALL(744)	AFR(207)	EUR(537)	ALL(744)	Secreted IFN-gamma response to smallpox vaccine	HPOID:0005368	Abnormality of humoral immunity	DOID:8736	smallpox	NA	NA	NA	NA	Virus disease	NA	Research Support, N.I.H., Extramural
5	3558538	rs10512697	T	C	rs10512697	22542470	9.00E-07	NA	NA	NA	217 African American ancestry individuals; 580 European ancestry individuals; 217 Hispanic ancestry individuals	European(580)	African American(217)	Hispanic(217)	ALL(1014)	HIS(217)	AFR(217)	EUR(580)	ALL(1014)	Immune response to smallpox vaccine (IL-6)	HPOID:0005368	Abnormality of humoral immunity	DOID:8736	smallpox	D012899	Smallpox	EFOID:0004873	response to vaccine	Virus disease
5	53902339	rs2548621	G	A	rs2548621	22542470	9.00E-07	NA	NA	NA	217 African American ancestry individuals; 580 European ancestry individuals; 217 Hispanic ancestry individuals	European(580)	African American(217)	Hispanic(217)	ALL(1014)	HIS(217)	AFR(217)	EUR(580)	ALL(1014)	Immune response to smallpox vaccine (IL-6)	HPOID:0005368	Abnormality of humoral immunity	DOID:8736	smallpox	D012899	Smallpox	EFOID:0004873	response to vaccine	Virus disease
5	58560717	rs17444059	T	C	rs17444059	22610502	2.00E-08	NA	NA	NA	Up to 512 European ancestry individuals; 199 African American individuals	African American(199)	European(512)	ALL(711)	AFR(199)	EUR(512)	ALL(711)	Immune response to smallpox vaccine (IL-6)	HPOID:0005368	Abnormality of humoral immunity	DOID:8736	smallpox	D012899	Smallpox	EFOID:0004873	response to vaccine	Virus disease	rs17444059-G	Research Support, N.I.H., Extramural
5	86524315	rs6890495	G	A	rs6890495	22661280	1.39E-10	NA	NA	NA	537 European ancestry individuals; 207 African American individuals	African American(207)	European(537)	ALL(744)	AFR(207)	EUR(537)	ALL(744)	CD8+ T cell IFN-gamma response to smallpox vaccine	HPOID:0005368	Abnormality of humoral immunity	DOID:8736	smallpox	NA	NA	NA	NA	Virus disease	NA	Research Support, N.I.H., Extramural
5	91518721	rs10055544	G	A	rs10055544	22610502	1.00E-07	NA	NA	NA	Up to 512 European ancestry individuals; up to 199 African American individuals	African American(199)	European(512)	ALL(711)	AFR(199)	EUR(512)	ALL(711)	Immune reponse to smallpox (secreted IL-10)	HPOID:0005368	Abnormality of humoral immunity	DOID:8736	smallpox	D012899	Smallpox	EFOID:0004645	cytokine measurement	Virus disease	rs10055544-A	Research Support, N.I.H., Extramural
5	119937691	rs1584468	G	A,C,T	rs1584468	22610502	9.00E-08	NA	NA	NA	Up to 512 European ancestry individuals; up to 199 African American individuals	African American(199)	European(512)	ALL(711)	AFR(199)	EUR(512)	ALL(711)	Immune reponse to smallpox (secreted IL-12p40)	HPOID:0005368	Abnormality of humoral immunity	DOID:8736	smallpox	D012899	Smallpox	EFOID:0004873	response to vaccine	Virus disease	rs1584468-A	Research Support, N.I.H., Extramural
5	137599334	rs11242417	T	G	rs11242417	22610502	6.00E-08	NA	NA	NA	Up to 512 European ancestry individuals; up to 199 African American individuals	African American(199)	European(512)	ALL(711)	AFR(199)	EUR(512)	ALL(711)	Immune reponse to smallpox (secreted IL-12p40)	HPOID:0005368	Abnormality of humoral immunity	DOID:8736	smallpox	D012899	Smallpox	EFOID:0004873	response to vaccine	Virus disease	rs11242417-C	Research Support, N.I.H., Extramural
5	138850905	rs13181561	G	A	rs13181561	22610502	3.00E-14	EA	NA	NA	Up to 512 European ancestry individuals; up to 199 African American individuals	African American(199)	European(512)	ALL(711)	AFR(199)	EUR(512)	ALL(711)	Immune reponse to smallpox (secreted IFN-alpha)	HPOID:0005368	Abnormality of humoral immunity	DOID:8736	smallpox	D012899	Smallpox	EFOID:0004873	response to vaccine	Virus disease	rs13181561-G	Research Support, N.I.H., Extramural
5	138949362	rs261532	G	T	rs261532	22610502	3.00E-07	NA	NA	NA	Up to 512 European ancestry individuals; up to 199 African American individuals	African American(199)	European(512)	ALL(711)	AFR(199)	EUR(512)	ALL(711)	Immune reponse to smallpox (secreted IFN-alpha)	HPOID:0005368	Abnormality of humoral immunity	DOID:8736	smallpox	D012899	Smallpox	EFOID:0004873	response to vaccine	Virus disease	rs261532-A	Research Support, N.I.H., Extramural
5	167210472	rs2973662	A	G	rs2973662	22610502	5.00E-07	NA	NA	NA	Up to 512 European ancestry individuals; 199 African American individuals	African American(199)	European(512)	ALL(711)	AFR(199)	EUR(512)	ALL(711)	Immune response to smallpox vaccine (IL-6)	HPOID:0005368	Abnormality of humoral immunity	DOID:8736	smallpox	D012899	Smallpox	EFOID:0004873	response to vaccine	Virus disease	rs2973662-A	Research Support, N.I.H., Extramural
6	17241154	rs1322846	T	C	rs1322846	22542470	6.00E-07	NA	NA	NA	217 African American ancestry individuals; 580 European ancestry individuals; 217 Hispanic ancestry individuals	European(580)	African American(217)	Hispanic(217)	ALL(1014)	HIS(217)	AFR(217)	EUR(580)	ALL(1014)	Immune response to smallpox vaccine (IL-6)	HPOID:0005368	Abnormality of humoral immunity	DOID:8736	smallpox	D012899	Smallpox	EFOID:0004873	response to vaccine	Virus disease
6	23437676	rs7771911	C	A	rs7771911	22610502	2.00E-12	EA	NA	NA	Up to 512 European ancestry individuals; up to 199 African American individuals	African American(199)	European(512)	ALL(711)	AFR(199)	EUR(512)	ALL(711)	Immune reponse to smallpox (secreted IL-12p40)	HPOID:0005368	Abnormality of humoral immunity	DOID:8736	smallpox	D012899	Smallpox	EFOID:0004873	response to vaccine	Virus disease	rs7771911-A	Research Support, N.I.H., Extramural
6	29434414	rs4713226	G	A	rs4713226	22610502	2.00E-08	NA	NA	NA	Up to 512 European ancestry individuals; up to 199 African American individuals	African American(199)	European(512)	ALL(711)	AFR(199)	EUR(512)	ALL(711)	Immune reponse to smallpox (secreted IFN-alpha)	HPOID:0005368	Abnormality of humoral immunity	DOID:8736	smallpox	D012899	Smallpox	EFOID:0004873	response to vaccine	Virus disease	rs4713226-A	Research Support, N.I.H., Extramural
6	39528982	rs9380880	G	A	rs9380880	22542470	1.00E-07	NA	NA	NA	217 African American ancestry individuals; 580 European ancestry individuals; 217 Hispanic ancestry individuals	European(580)	African American(217)	Hispanic(217)	ALL(1014)	HIS(217)	AFR(217)	EUR(580)	ALL(1014)	Immune response to smallpox vaccine (IL-6)	HPOID:0005368	Abnormality of humoral immunity	DOID:8736	smallpox	D012899	Smallpox	EFOID:0004873	response to vaccine	Virus disease
6	119866141	rs1392089	C	T	rs1392089	22610502	4.00E-07	NA	NA	NA	Up to 512 European ancestry individuals; up to 199 African American individuals	African American(199)	European(512)	ALL(711)	AFR(199)	EUR(512)	ALL(711)	Immune reponse to smallpox (secreted IL-2)	HPOID:0005368	Abnormality of humoral immunity	DOID:8736	smallpox	D012899	Smallpox	EFOID:0004645	cytokine measurement	Virus disease	rs1392089-A	Research Support, N.I.H., Extramural
6	128021803	rs17299841	A	C	rs17299841	22610502	2.00E-07	NA	NA	NA	Up to 512 European ancestry individuals; 199 African American individuals	African American(199)	European(512)	ALL(711)	AFR(199)	EUR(512)	ALL(711)	Immune response to smallpox vaccine (IL-6)	HPOID:0005368	Abnormality of humoral immunity	DOID:8736	smallpox	D012899	Smallpox	EFOID:0004873	response to vaccine	Virus disease	rs17299841-C	Research Support, N.I.H., Extramural
6	134576511	rs9493873	T	C	rs9493873	22610502	4.00E-07	NA	NA	NA	Up to 512 European ancestry individuals; up to 199 African American individuals	African American(199)	European(512)	ALL(711)	AFR(199)	EUR(512)	ALL(711)	Immune reponse to smallpox (secreted IFN-alpha)	HPOID:0005368	Abnormality of humoral immunity	DOID:8736	smallpox	D012899	Smallpox	EFOID:0004873	response to vaccine	Virus disease	rs9493873-G	Research Support, N.I.H., Extramural
6	136001003	rs9389316	C	A	rs9389316	22610502	7.00E-13	EA	NA	NA	Up to 512 European ancestry individuals; up to 199 African American individuals	African American(199)	European(512)	ALL(711)	AFR(199)	EUR(512)	ALL(711)	Immune reponse to smallpox (secreted IL-2)	HPOID:0005368	Abnormality of humoral immunity	DOID:8736	smallpox	D012899	Smallpox	EFOID:0004645	cytokine measurement	Virus disease	rs9389316-A	Research Support, N.I.H., Extramural
6	145287366	rs1953793	A	G	rs1953793	22661280	0.000000263	NA	NA	NA	537 European ancestry individuals; 207 African American individuals	African American(207)	European(537)	ALL(744)	AFR(207)	EUR(537)	ALL(744)	CD8+ T cell IFN-gamma response to smallpox vaccine	HPOID:0005368	Abnormality of humoral immunity	DOID:8736	smallpox	NA	NA	NA	NA	Virus disease	NA	Research Support, N.I.H., Extramural
6	145367318	rs6570670	T	G	rs6570670	22661280	4.74E-08	NA	NA	NA	537 European ancestry individuals; 207 African American individuals	African American(207)	European(537)	ALL(744)	AFR(207)	EUR(537)	ALL(744)	CD8+ T cell IFN-gamma response to smallpox vaccine	HPOID:0005368	Abnormality of humoral immunity	DOID:8736	smallpox	NA	NA	NA	NA	Virus disease	NA	Research Support, N.I.H., Extramural
6	154331184	rs1319339	T	C	rs1319339	22661280	0.000000491	NA	NA	NA	537 European ancestry individuals; 207 African American individuals	African American(207)	European(537)	ALL(744)	AFR(207)	EUR(537)	ALL(744)	Total IFN-gamma response to smallpox vaccine	HPOID:0005368	Abnormality of humoral immunity	DOID:8736	smallpox	NA	NA	NA	NA	Virus disease	NA	Research Support, N.I.H., Extramural
6	168511016	rs1473500	C	T	rs1473500	22610502	3.00E-07	NA	NA	NA	Up to 512 European ancestry individuals; up to 199 African American individuals	African American(199)	European(512)	ALL(711)	AFR(199)	EUR(512)	ALL(711)	Immune reponse to smallpox (secreted IL-2)	HPOID:0005368	Abnormality of humoral immunity	DOID:8736	smallpox	D012899	Smallpox	EFOID:0004645	cytokine measurement	Virus disease	rs1473500-A	Research Support, N.I.H., Extramural
7	7571420	rs17168526	T	C	rs17168526	22610502	6.00E-08	NA	NA	NA	Up to 512 European ancestry individuals; up to 199 African American individuals	African American(199)	European(512)	ALL(711)	AFR(199)	EUR(512)	ALL(711)	Immune reponse to smallpox (secreted IL-1beta)	HPOID:0005368	Abnormality of humoral immunity	DOID:8736	smallpox	D012899	Smallpox	EFOID:0004645	cytokine measurement	Virus disease	rs17168526-G	Research Support, N.I.H., Extramural
7	27335561	rs11564024	T	G	rs11564024	22610502	3.00E-08	NA	NA	NA	Up to 512 European ancestry individuals; up to 199 African American individuals	African American(199)	European(512)	ALL(711)	AFR(199)	EUR(512)	ALL(711)	Immune reponse to smallpox (secreted IL-1beta)	HPOID:0005368	Abnormality of humoral immunity	DOID:8736	smallpox	D012899	Smallpox	EFOID:0004645	cytokine measurement	Virus disease	rs11564024-C	Research Support, N.I.H., Extramural
7	68050413	rs1403155	G	A	rs1403155	22610502	2.00E-08	NA	NA	NA	Up to 512 European ancestry individuals; up to 199 African American individuals	African American(199)	European(512)	ALL(711)	AFR(199)	EUR(512)	ALL(711)	Immune reponse to smallpox (secreted IL-2)	HPOID:0005368	Abnormality of humoral immunity	DOID:8736	smallpox	D012899	Smallpox	EFOID:0004645	cytokine measurement	Virus disease	rs1403155-A	Research Support, N.I.H., Extramural
7	72746648	rs6943090	C	T	rs6943090	22610502	3.00E-07	NA	NA	NA	Up to 512 European ancestry individuals; up to 199 African American individuals	African American(199)	European(512)	ALL(711)	AFR(199)	EUR(512)	ALL(711)	Immune reponse to smallpox (secreted IL-12p40)	HPOID:0005368	Abnormality of humoral immunity	DOID:8736	smallpox	D012899	Smallpox	EFOID:0004873	response to vaccine	Virus disease	rs6943090-A	Research Support, N.I.H., Extramural
7	79796815	rs2523194	A	G	rs2523194	22661280	0.000000148	NA	NA	NA	537 European ancestry individuals; 207 African American individuals	African American(207)	European(537)	ALL(744)	AFR(207)	EUR(537)	ALL(744)	Total IFN-gamma response to smallpox vaccine	HPOID:0005368	Abnormality of humoral immunity	DOID:8736	smallpox	NA	NA	NA	NA	Virus disease	NA	Research Support, N.I.H., Extramural
7	94047266	rs3736638	C	A	rs3736638	22610502	3.00E-07	NA	NA	NA	Up to 512 European ancestry individuals; up to 199 African American individuals	African American(199)	European(512)	ALL(711)	AFR(199)	EUR(512)	ALL(711)	Immune reponse to smallpox (secreted IL-12p40)	HPOID:0005368	Abnormality of humoral immunity	DOID:8736	smallpox	D012899	Smallpox	EFOID:0004873	response to vaccine	Virus disease	rs3736638-A	Research Support, N.I.H., Extramural
7	95600368	rs13231718	T	G	rs13231718	22610502	5.00E-09	NA	NA	NA	Up to 512 European ancestry individuals; up to 199 African American individuals	African American(199)	European(512)	ALL(711)	AFR(199)	EUR(512)	ALL(711)	Immune reponse to smallpox (secreted IL-10)	HPOID:0005368	Abnormality of humoral immunity	DOID:8736	smallpox	D012899	Smallpox	EFOID:0004645	cytokine measurement	Virus disease	rs13231718-C	Research Support, N.I.H., Extramural
7	119606632	rs17142462	C	T	rs17142462	22610502	3.00E-09	NA	NA	NA	Up to 512 European ancestry individuals; up to 199 African American individuals	African American(199)	European(512)	ALL(711)	AFR(199)	EUR(512)	ALL(711)	Immune reponse to smallpox (secreted IL-12p40)	HPOID:0005368	Abnormality of humoral immunity	DOID:8736	smallpox	D012899	Smallpox	EFOID:0004873	response to vaccine	Virus disease	rs17142462-A	Research Support, N.I.H., Extramural
7	134785741	rs17231212	T	C	rs17231212	22610502	2.00E-08	NA	NA	NA	Up to 512 European ancestry individuals; up to 199 African American individuals	African American(199)	European(512)	ALL(711)	AFR(199)	EUR(512)	ALL(711)	Immune reponse to smallpox (secreted IL-10)	HPOID:0005368	Abnormality of humoral immunity	DOID:8736	smallpox	D012899	Smallpox	EFOID:0004645	cytokine measurement	Virus disease	rs17231212-G	Research Support, N.I.H., Extramural
7	139576284	rs17161201	G	A	rs17161201	22661280	0.00000015	NA	NA	NA	537 European ancestry individuals; 207 African American individuals	African American(207)	European(537)	ALL(744)	AFR(207)	EUR(537)	ALL(744)	Total IFN-gamma response to smallpox vaccine	HPOID:0005368	Abnormality of humoral immunity	DOID:8736	smallpox	NA	NA	NA	NA	Virus disease	NA	Research Support, N.I.H., Extramural
8	4299883	rs17070309	G	A	rs17070309	22542470	5.00E-07	NA	NA	NA	217 African American ancestry individuals; 580 European ancestry individuals; 217 Hispanic ancestry individuals	European(580)	African American(217)	Hispanic(217)	ALL(1014)	HIS(217)	AFR(217)	EUR(580)	ALL(1014)	Immune response to smallpox vaccine (IL-6)	HPOID:0005368	Abnormality of humoral immunity	DOID:8736	smallpox	D012899	Smallpox	EFOID:0004873	response to vaccine	Virus disease
8	11409992	rs2255327	C	T	rs2255327	22610502	3.00E-07	NA	NA	NA	Up to 512 European ancestry individuals; 199 African American individuals	African American(199)	European(512)	ALL(711)	AFR(199)	EUR(512)	ALL(711)	Immune response to smallpox vaccine (IL-6)	HPOID:0005368	Abnormality of humoral immunity	DOID:8736	smallpox	D012899	Smallpox	EFOID:0004873	response to vaccine	Virus disease	rs2255327-A	Research Support, N.I.H., Extramural
8	18355897	rs4921930	C	T	rs4921930	22661280	1.15E-12	NA	NA	NA	537 European ancestry individuals; 207 African American individuals	African American(207)	European(537)	ALL(744)	AFR(207)	EUR(537)	ALL(744)	CD8+ T cell IFN-gamma response to smallpox vaccine	HPOID:0005368	Abnormality of humoral immunity	DOID:8736	smallpox	NA	NA	NA	NA	Virus disease	NA	Research Support, N.I.H., Extramural
8	18360301	rs1110820	T	C	rs1110820	22661280	1.15E-12	NA	NA	NA	537 European ancestry individuals; 207 African American individuals	African American(207)	European(537)	ALL(744)	AFR(207)	EUR(537)	ALL(744)	CD8+ T cell IFN-gamma response to smallpox vaccine	HPOID:0005368	Abnormality of humoral immunity	DOID:8736	smallpox	NA	NA	NA	NA	Virus disease	NA	Research Support, N.I.H., Extramural
8	33565378	rs4469412	G	A	rs4469412	22542470	9.00E-07	NA	NA	NA	217 African American ancestry individuals; 580 European ancestry individuals; 217 Hispanic ancestry individuals	European(580)	African American(217)	Hispanic(217)	ALL(1014)	HIS(217)	AFR(217)	EUR(580)	ALL(1014)	Immune response to smallpox vaccine (IL-6)	HPOID:0005368	Abnormality of humoral immunity	DOID:8736	smallpox	D012899	Smallpox	EFOID:0004873	response to vaccine	Virus disease
8	33665680	rs10503951	A	G	rs10503951	22542470	3.00E-09	NA	NA	NA	217 African American ancestry individuals; 580 European ancestry individuals; 217 Hispanic ancestry individuals	European(580)	African American(217)	Hispanic(217)	ALL(1014)	HIS(217)	AFR(217)	EUR(580)	ALL(1014)	Immune response to smallpox vaccine (IL-6)	HPOID:0005368	Abnormality of humoral immunity	DOID:8736	smallpox	D012899	Smallpox	EFOID:0004873	response to vaccine	Virus disease
8	33673011	rs11786194	A	G	rs11786194	22542470	9.00E-07	NA	NA	NA	217 African American ancestry individuals; 580 European ancestry individuals; 217 Hispanic ancestry individuals	European(580)	African American(217)	Hispanic(217)	ALL(1014)	HIS(217)	AFR(217)	EUR(580)	ALL(1014)	Immune response to smallpox vaccine (IL-6)	HPOID:0005368	Abnormality of humoral immunity	DOID:8736	smallpox	D012899	Smallpox	EFOID:0004873	response to vaccine	Virus disease
8	33696302	rs11787122	A	G	rs11787122	22542470	8.54E-07	NA	NA	NA	217 African American ancestry individuals; 580 European ancestry individuals; 217 Hispanic ancestry individuals	European(580)	African American(217)	Hispanic(217)	ALL(1014)	HIS(217)	AFR(217)	EUR(580)	ALL(1014)	Immune response to smallpox vaccine (IL-6)	HPOID:0005368	Abnormality of humoral immunity	DOID:8736	smallpox	D012899	Smallpox	EFOID:0004873	response to vaccine	Virus disease
8	56168059	rs12542677	C	T	rs12542677	22610502	2.00E-07	NA	NA	NA	Up to 512 European ancestry individuals; up to 199 African American individuals	African American(199)	European(512)	ALL(711)	AFR(199)	EUR(512)	ALL(711)	Immune reponse to smallpox (secreted IL-1beta)	HPOID:0005368	Abnormality of humoral immunity	DOID:8736	smallpox	D012899	Smallpox	EFOID:0004645	cytokine measurement	Virus disease	rs12542677-A	Research Support, N.I.H., Extramural
8	123973068	rs10108684	G	A	rs10108684	22542470	1.00E-08	NA	NA	NA	217 African American ancestry individuals; 580 European ancestry individuals; 217 Hispanic ancestry individuals	European(580)	African American(217)	Hispanic(217)	ALL(1014)	HIS(217)	AFR(217)	EUR(580)	ALL(1014)	Immune response to smallpox vaccine (IL-6)	HPOID:0005368	Abnormality of humoral immunity	DOID:8736	smallpox	D012899	Smallpox	EFOID:0004873	response to vaccine	Virus disease
9	14119810	rs7860845	A	G	rs7860845	22661280	9.48E-14	NA	NA	NA	537 European ancestry individuals; 207 African American individuals	African American(207)	European(537)	ALL(744)	AFR(207)	EUR(537)	ALL(744)	Total IFN-gamma response to smallpox vaccine	HPOID:0005368	Abnormality of humoral immunity	DOID:8736	smallpox	NA	NA	NA	NA	Virus disease	NA	Research Support, N.I.H., Extramural
9	32556380	rs17290760	A	G	rs17290760	22610502	1.00E-07	NA	NA	NA	Up to 512 European ancestry individuals; 199 African American individuals	African American(199)	European(512)	ALL(711)	AFR(199)	EUR(512)	ALL(711)	Immune response to smallpox vaccine (IL-6)	HPOID:0005368	Abnormality of humoral immunity	DOID:8736	smallpox	D012899	Smallpox	EFOID:0004873	response to vaccine	Virus disease	rs17290760-G	Research Support, N.I.H., Extramural
9	90209137	rs3095748	G	A	rs3095748	22610502	5.00E-07	NA	NA	NA	Up to 512 European ancestry individuals; up to 199 African American individuals	African American(199)	European(512)	ALL(711)	AFR(199)	EUR(512)	ALL(711)	Immune reponse to smallpox (secreted IFN-alpha)	HPOID:0005368	Abnormality of humoral immunity	DOID:8736	smallpox	D012899	Smallpox	EFOID:0004873	response to vaccine	Virus disease	rs3095748-G	Research Support, N.I.H., Extramural
9	123914874	rs9408926	C	T	rs9408926	22610502	4.00E-08	NA	NA	NA	Up to 512 European ancestry individuals; up to 199 African American individuals	African American(199)	European(512)	ALL(711)	AFR(199)	EUR(512)	ALL(711)	Immune reponse to smallpox (secreted IFN-alpha)	HPOID:0005368	Abnormality of humoral immunity	DOID:8736	smallpox	D012899	Smallpox	EFOID:0004873	response to vaccine	Virus disease	rs9408926-A	Research Support, N.I.H., Extramural
9	123951917	rs9408928	T	C	rs9408928	22610502	4.00E-09	NA	NA	NA	Up to 512 European ancestry individuals; up to 199 African American individuals	African American(199)	European(512)	ALL(711)	AFR(199)	EUR(512)	ALL(711)	Immune reponse to smallpox (secreted IFN-alpha)	HPOID:0005368	Abnormality of humoral immunity	DOID:8736	smallpox	D012899	Smallpox	EFOID:0004873	response to vaccine	Virus disease	rs9408928-G	Research Support, N.I.H., Extramural
10	618685	rs17221323	T	C	rs17221323	22610502	1.00E-07	NA	NA	NA	Up to 512 European ancestry individuals; up to 199 African American individuals	African American(199)	European(512)	ALL(711)	AFR(199)	EUR(512)	ALL(711)	Immune reponse to smallpox (secreted IFN-alpha)	HPOID:0005368	Abnormality of humoral immunity	DOID:8736	smallpox	D012899	Smallpox	EFOID:0004873	response to vaccine	Virus disease	rs17221323-G	Research Support, N.I.H., Extramural
10	6606541	rs4748153	C	T	rs4748153	22542470	3.00E-08	NA	NA	NA	217 African American ancestry individuals; 580 European ancestry individuals; 217 Hispanic ancestry individuals	European(580)	African American(217)	Hispanic(217)	ALL(1014)	HIS(217)	AFR(217)	EUR(580)	ALL(1014)	Immune response to smallpox vaccine (IL-6)	HPOID:0005368	Abnormality of humoral immunity	DOID:8736	smallpox	D012899	Smallpox	EFOID:0004873	response to vaccine	Virus disease
10	9363877	rs12247397	A	G	rs12247397	22610502	3.00E-09	NA	NA	NA	Up to 512 European ancestry individuals; up to 199 African American individuals	African American(199)	European(512)	ALL(711)	AFR(199)	EUR(512)	ALL(711)	Immune reponse to smallpox (secreted IL-1beta)	HPOID:0005368	Abnormality of humoral immunity	DOID:8736	smallpox	D012899	Smallpox	EFOID:0004645	cytokine measurement	Virus disease	rs12247397-G	Research Support, N.I.H., Extramural
10	25918879	rs12775535	C	T	rs12775535	22542470	4.00E-09	NA	NA	NA	217 African American ancestry individuals; 580 European ancestry individuals; 217 Hispanic ancestry individuals	European(580)	African American(217)	Hispanic(217)	ALL(1014)	HIS(217)	AFR(217)	EUR(580)	ALL(1014)	Immune response to smallpox vaccine (IL-6)	HPOID:0005368	Abnormality of humoral immunity	DOID:8736	smallpox	D012899	Smallpox	EFOID:0004873	response to vaccine	Virus disease
10	28025771	rs10508727	C	T	rs10508727	22542470	1.00E-10	AA	NA	NA	217 African American ancestry individuals; 580 European ancestry individuals; 217 Hispanic ancestry individuals	European(580)	African American(217)	Hispanic(217)	ALL(1014)	HIS(217)	AFR(217)	EUR(580)	ALL(1014)	Immune response to smallpox vaccine (IL-6)	HPOID:0005368	Abnormality of humoral immunity	DOID:8736	smallpox	D012899	Smallpox	EFOID:0004873	response to vaccine	Virus disease
10	55384743	rs12256830	C	T	rs12256830	22542470	2.00E-10	Hispanic	NA	NA	217 African American ancestry individuals; 580 European ancestry individuals; 217 Hispanic ancestry individuals	European(580)	African American(217)	Hispanic(217)	ALL(1014)	HIS(217)	AFR(217)	EUR(580)	ALL(1014)	Immune response to smallpox vaccine (IL-6)	HPOID:0005368	Abnormality of humoral immunity	DOID:8736	smallpox	D012899	Smallpox	EFOID:0004873	response to vaccine	Virus disease
10	70939801	rs10998624	G	A	rs10998624	22610502	1.00E-09	NA	NA	NA	Up to 512 European ancestry individuals; up to 199 African American individuals	African American(199)	European(512)	ALL(711)	AFR(199)	EUR(512)	ALL(711)	Immune reponse to smallpox (secreted IL-1beta)	HPOID:0005368	Abnormality of humoral immunity	DOID:8736	smallpox	D012899	Smallpox	EFOID:0004645	cytokine measurement	Virus disease	rs10998624-A	Research Support, N.I.H., Extramural
10	90746693	rs983751	A	C	rs983751	22661280	1.97E-08	NA	NA	NA	537 European ancestry individuals; 207 African American individuals	African American(207)	European(537)	ALL(744)	AFR(207)	EUR(537)	ALL(744)	Total IFN-gamma response to smallpox vaccine	HPOID:0005368	Abnormality of humoral immunity	DOID:8736	smallpox	NA	NA	NA	NA	Virus disease	NA	Research Support, N.I.H., Extramural
10	90748736	rs3758483	C	T	rs3758483	22661280	1.97E-08	NA	NA	NA	537 European ancestry individuals; 207 African American individuals	African American(207)	European(537)	ALL(744)	AFR(207)	EUR(537)	ALL(744)	Total IFN-gamma response to smallpox vaccine	HPOID:0005368	Abnormality of humoral immunity	DOID:8736	smallpox	NA	NA	NA	NA	Virus disease	NA	Research Support, N.I.H., Extramural
10	90756163	rs9658691	T	C	rs9658691	22661280	1.63E-09	NA	NA	NA	537 European ancestry individuals; 207 African American individuals	African American(207)	European(537)	ALL(744)	AFR(207)	EUR(537)	ALL(744)	Total IFN-gamma response to smallpox vaccine	HPOID:0005368	Abnormality of humoral immunity	DOID:8736	smallpox	NA	NA	NA	NA	Virus disease	NA	Research Support, N.I.H., Extramural
10	96766934	rs2860975	A	C	rs2860975	22542470	2.00E-07	NA	NA	NA	217 African American ancestry individuals; 580 European ancestry individuals; 217 Hispanic ancestry individuals	European(580)	African American(217)	Hispanic(217)	ALL(1014)	HIS(217)	AFR(217)	EUR(580)	ALL(1014)	Immune response to smallpox vaccine (IL-6)	HPOID:0005368	Abnormality of humoral immunity	DOID:8736	smallpox	D012899	Smallpox	EFOID:0004873	response to vaccine	Virus disease
10	96797470	rs1934953	C	T	rs1934953	22542470	5.00E-07	NA	NA	NA	217 African American ancestry individuals; 580 European ancestry individuals; 217 Hispanic ancestry individuals	European(580)	African American(217)	Hispanic(217)	ALL(1014)	HIS(217)	AFR(217)	EUR(580)	ALL(1014)	Immune response to smallpox vaccine (IL-6)	HPOID:0005368	Abnormality of humoral immunity	DOID:8736	smallpox	D012899	Smallpox	EFOID:0004873	response to vaccine	Virus disease
10	100981547	rs7094333	C	T	rs7094333	22661280	1.04E-08	NA	NA	NA	537 European ancestry individuals; 207 African American individuals	African American(207)	European(537)	ALL(744)	AFR(207)	EUR(537)	ALL(744)	Secreted IFN-gamma response to smallpox vaccine	HPOID:0005368	Abnormality of humoral immunity	DOID:8736	smallpox	NA	NA	NA	NA	Virus disease	NA	Research Support, N.I.H., Extramural
10	108500404	rs10458732	C	T	rs10458732	22661280	0.000000461	NA	NA	NA	537 European ancestry individuals; 207 African American individuals	African American(207)	European(537)	ALL(744)	AFR(207)	EUR(537)	ALL(744)	Secreted IFN-gamma response to smallpox vaccine	HPOID:0005368	Abnormality of humoral immunity	DOID:8736	smallpox	NA	NA	NA	NA	Virus disease	NA	Research Support, N.I.H., Extramural
10	132847790	rs12764951	C	T	rs12764951	22661280	0.000000284	NA	NA	NA	537 European ancestry individuals; 207 African American individuals	African American(207)	European(537)	ALL(744)	AFR(207)	EUR(537)	ALL(744)	CD8+ T cell IFN-gamma response to smallpox vaccine	HPOID:0005368	Abnormality of humoral immunity	DOID:8736	smallpox	NA	NA	NA	NA	Virus disease	NA	Research Support, N.I.H., Extramural
11	2764118	rs2237875	A	G	rs2237875	22661280	0.000000121	NA	NA	NA	537 European ancestry individuals; 207 African American individuals	African American(207)	European(537)	ALL(744)	AFR(207)	EUR(537)	ALL(744)	Total IFN-gamma response to smallpox vaccine	HPOID:0005368	Abnormality of humoral immunity	DOID:8736	smallpox	NA	NA	NA	NA	Virus disease	NA	Research Support, N.I.H., Extramural
11	16358722	rs1437635	C	A	rs1437635	22661280	2.51E-08	NA	NA	NA	537 European ancestry individuals; 207 African American individuals	African American(207)	European(537)	ALL(744)	AFR(207)	EUR(537)	ALL(744)	Secreted IFN-gamma response to smallpox vaccine	HPOID:0005368	Abnormality of humoral immunity	DOID:8736	smallpox	NA	NA	NA	NA	Virus disease	NA	Research Support, N.I.H., Extramural
11	38288593	rs11034653	C	T	rs11034653	22610502	2.00E-07	NA	NA	NA	Up to 512 European ancestry individuals; up to 199 African American individuals	African American(199)	European(512)	ALL(711)	AFR(199)	EUR(512)	ALL(711)	Immune reponse to smallpox (secreted IL-12p40)	HPOID:0005368	Abnormality of humoral immunity	DOID:8736	smallpox	D012899	Smallpox	EFOID:0004873	response to vaccine	Virus disease	rs11034653-A	Research Support, N.I.H., Extramural
11	42315886	rs7394570	A	G	rs7394570	22542470	1.00E-06	NA	NA	NA	217 African American ancestry individuals; 580 European ancestry individuals; 217 Hispanic ancestry individuals	European(580)	African American(217)	Hispanic(217)	ALL(1014)	HIS(217)	AFR(217)	EUR(580)	ALL(1014)	Immune response to smallpox vaccine (IL-6)	HPOID:0005368	Abnormality of humoral immunity	DOID:8736	smallpox	D012899	Smallpox	EFOID:0004873	response to vaccine	Virus disease
11	61494327	rs4963243	G	A	rs4963243	22610502	2.00E-07	NA	NA	NA	Up to 512 European ancestry individuals; up to 199 African American individuals	African American(199)	European(512)	ALL(711)	AFR(199)	EUR(512)	ALL(711)	Immune reponse to smallpox (secreted IL-2)	HPOID:0005368	Abnormality of humoral immunity	DOID:8736	smallpox	D012899	Smallpox	EFOID:0004645	cytokine measurement	Virus disease	rs4963243-A	Research Support, N.I.H., Extramural
11	70704905	rs11237722	C	T	rs11237722	22661280	0.000000121	NA	NA	NA	537 European ancestry individuals; 207 African American individuals	African American(207)	European(537)	ALL(744)	AFR(207)	EUR(537)	ALL(744)	Total IFN-gamma response to smallpox vaccine	HPOID:0005368	Abnormality of humoral immunity	DOID:8736	smallpox	NA	NA	NA	NA	Virus disease	NA	Research Support, N.I.H., Extramural
11	100173537	rs11223581	A	G	rs11223581	22610502	9.00E-09	NA	NA	NA	Up to 512 European ancestry individuals; up to 199 African American individuals	African American(199)	European(512)	ALL(711)	AFR(199)	EUR(512)	ALL(711)	Immune reponse to smallpox (secreted IL-2)	HPOID:0005368	Abnormality of humoral immunity	DOID:8736	smallpox	D012899	Smallpox	EFOID:0004645	cytokine measurement	Virus disease	rs11223581-G	Research Support, N.I.H., Extramural
11	112064431	rs7105056	T	C	rs7105056	22610502	1.00E-08	NA	NA	NA	Up to 512 European ancestry individuals; up to 199 African American individuals	African American(199)	European(512)	ALL(711)	AFR(199)	EUR(512)	ALL(711)	Immune reponse to smallpox (secreted IL-12p40)	HPOID:0005368	Abnormality of humoral immunity	DOID:8736	smallpox	D012899	Smallpox	EFOID:0004873	response to vaccine	Virus disease	rs7105056-A	Research Support, N.I.H., Extramural
11	118075152	rs11216816	C	A	rs11216816	22661280	0.00000045	NA	NA	NA	537 European ancestry individuals; 207 African American individuals	African American(207)	European(537)	ALL(744)	AFR(207)	EUR(537)	ALL(744)	Secreted IFN-gamma response to smallpox vaccine	HPOID:0005368	Abnormality of humoral immunity	DOID:8736	smallpox	NA	NA	NA	NA	Virus disease	NA	Research Support, N.I.H., Extramural
11	123864216	rs1453654	T	C	rs1453654	22661280	0.000000141	NA	NA	NA	537 European ancestry individuals; 207 African American individuals	African American(207)	European(537)	ALL(744)	AFR(207)	EUR(537)	ALL(744)	Secreted IFN-gamma response to smallpox vaccine	HPOID:0005368	Abnormality of humoral immunity	DOID:8736	smallpox	NA	NA	NA	NA	Virus disease	NA	Research Support, N.I.H., Extramural
12	13872044	rs2268118	G	T	rs2268118	22610502	1.00E-08	NA	NA	NA	Up to 512 European ancestry individuals; up to 199 African American individuals	African American(199)	European(512)	ALL(711)	AFR(199)	EUR(512)	ALL(711)	Immune reponse to smallpox (secreted IL-2)	HPOID:0005368	Abnormality of humoral immunity	DOID:8736	smallpox	D012899	Smallpox	EFOID:0004645	cytokine measurement	Virus disease	rs2268118-A	Research Support, N.I.H., Extramural
12	44153826	rs4251424	C	T	rs4251424	22610502	2.00E-08	NA	NA	NA	Up to 512 European ancestry individuals; up to 199 African American individuals	African American(199)	European(512)	ALL(711)	AFR(199)	EUR(512)	ALL(711)	Immune reponse to smallpox (secreted TNF-alpha)	HPOID:0005368	Abnormality of humoral immunity	DOID:8736	smallpox	D012899	Smallpox	EFOID:0004645	cytokine measurement	Virus disease	rs4251424-A	Research Support, N.I.H., Extramural
12	56828056	rs11171846	C	T	rs11171846	22610502	6.00E-10	AA	NA	NA	Up to 512 European ancestry individuals; up to 199 African American individuals	African American(199)	European(512)	ALL(711)	AFR(199)	EUR(512)	ALL(711)	Immune reponse to smallpox (secreted IFN-alpha)	HPOID:0005368	Abnormality of humoral immunity	DOID:8736	smallpox	D012899	Smallpox	EFOID:0004873	response to vaccine	Virus disease	rs11171846-A	Research Support, N.I.H., Extramural
12	63249773	rs3847906	A	G	rs3847906	22661280	0.000000186	NA	NA	NA	537 European ancestry individuals; 207 African American individuals	African American(207)	European(537)	ALL(744)	AFR(207)	EUR(537)	ALL(744)	Secreted IFN-gamma response to smallpox vaccine	HPOID:0005368	Abnormality of humoral immunity	DOID:8736	smallpox	NA	NA	NA	NA	Virus disease	NA	Research Support, N.I.H., Extramural
12	82984879	rs12425131	G	A	rs12425131	22542470	2.00E-06	NA	NA	NA	217 African American ancestry individuals; 580 European ancestry individuals; 217 Hispanic ancestry individuals	European(580)	African American(217)	Hispanic(217)	ALL(1014)	HIS(217)	AFR(217)	EUR(580)	ALL(1014)	Immune response to smallpox vaccine (IL-6)	HPOID:0005368	Abnormality of humoral immunity	DOID:8736	smallpox	D012899	Smallpox	EFOID:0004873	response to vaccine	Virus disease
12	83019188	rs11115322	T	C	rs11115322	22542470	3.00E-06	NA	NA	NA	217 African American ancestry individuals; 580 European ancestry individuals; 217 Hispanic ancestry individuals	European(580)	African American(217)	Hispanic(217)	ALL(1014)	HIS(217)	AFR(217)	EUR(580)	ALL(1014)	Immune response to smallpox vaccine (IL-6)	HPOID:0005368	Abnormality of humoral immunity	DOID:8736	smallpox	D012899	Smallpox	EFOID:0004873	response to vaccine	Virus disease
12	133345809	rs12282	C	T	rs12282	22542470	3.00E-07	NA	NA	NA	217 African American ancestry individuals; 580 European ancestry individuals; 217 Hispanic ancestry individuals	European(580)	African American(217)	Hispanic(217)	ALL(1014)	HIS(217)	AFR(217)	EUR(580)	ALL(1014)	Immune response to smallpox vaccine (IL-6)	HPOID:0005368	Abnormality of humoral immunity	DOID:8736	smallpox	D012899	Smallpox	EFOID:0004873	response to vaccine	Virus disease
13	74995660	rs17714988	A	G	rs17714988	22610502	3.00E-07	NA	NA	NA	Up to 512 European ancestry individuals; up to 199 African American individuals	African American(199)	European(512)	ALL(711)	AFR(199)	EUR(512)	ALL(711)	Immune reponse to smallpox (secreted IFN-alpha)	HPOID:0005368	Abnormality of humoral immunity	DOID:8736	smallpox	D012899	Smallpox	EFOID:0004873	response to vaccine	Virus disease	rs17714988-G	Research Support, N.I.H., Extramural
13	99385990	rs9582259	T	G	rs9582259	22610502	3.00E-08	NA	NA	NA	Up to 512 European ancestry individuals; up to 199 African American individuals	African American(199)	European(512)	ALL(711)	AFR(199)	EUR(512)	ALL(711)	Immune reponse to smallpox (secreted IL-1beta)	HPOID:0005368	Abnormality of humoral immunity	DOID:8736	smallpox	D012899	Smallpox	EFOID:0004645	cytokine measurement	Virus disease	rs9582259-C	Research Support, N.I.H., Extramural
13	105091080	rs7987983	G	A	rs7987983	22661280	0.000000187	NA	NA	NA	537 European ancestry individuals; 207 African American individuals	African American(207)	European(537)	ALL(744)	AFR(207)	EUR(537)	ALL(744)	Secreted IFN-gamma response to smallpox vaccine	HPOID:0005368	Abnormality of humoral immunity	DOID:8736	smallpox	NA	NA	NA	NA	Virus disease	NA	Research Support, N.I.H., Extramural
13	105112042	rs7337090	G	A	rs7337090	22661280	0.000000701	NA	NA	NA	537 European ancestry individuals; 207 African American individuals	African American(207)	European(537)	ALL(744)	AFR(207)	EUR(537)	ALL(744)	Secreted IFN-gamma response to smallpox vaccine	HPOID:0005368	Abnormality of humoral immunity	DOID:8736	smallpox	NA	NA	NA	NA	Virus disease	NA	Research Support, N.I.H., Extramural
13	106785265	rs1372791	T	C	rs1372791	22610502	4.00E-07	NA	NA	NA	Up to 512 European ancestry individuals; up to 199 African American individuals	African American(199)	European(512)	ALL(711)	AFR(199)	EUR(512)	ALL(711)	Immune reponse to smallpox (secreted IL-2)	HPOID:0005368	Abnormality of humoral immunity	DOID:8736	smallpox	D012899	Smallpox	EFOID:0004645	cytokine measurement	Virus disease	rs1372791-A	Research Support, N.I.H., Extramural
13	106941798	rs16968401	G	A	rs16968401	22661280	0.00000035	NA	NA	NA	537 European ancestry individuals; 207 African American individuals	African American(207)	European(537)	ALL(744)	AFR(207)	EUR(537)	ALL(744)	Secreted IFN-gamma response to smallpox vaccine	HPOID:0005368	Abnormality of humoral immunity	DOID:8736	smallpox	NA	NA	NA	NA	Virus disease	NA	Research Support, N.I.H., Extramural
14	49463484	rs11845208	A	G	rs11845208	22610502	1.00E-07	NA	NA	NA	Up to 512 European ancestry individuals; up to 199 African American individuals	African American(199)	European(512)	ALL(711)	AFR(199)	EUR(512)	ALL(711)	Immune reponse to smallpox (secreted IL-2)	HPOID:0005368	Abnormality of humoral immunity	DOID:8736	smallpox	D012899	Smallpox	EFOID:0004645	cytokine measurement	Virus disease	rs11845208-G	Research Support, N.I.H., Extramural
14	54167472	rs210359	A	C	rs210359	22610502	8.00E-08	NA	NA	NA	Up to 512 European ancestry individuals; up to 199 African American individuals	African American(199)	European(512)	ALL(711)	AFR(199)	EUR(512)	ALL(711)	Immune reponse to smallpox (secreted IFN-alpha)	HPOID:0005368	Abnormality of humoral immunity	DOID:8736	smallpox	D012899	Smallpox	EFOID:0004873	response to vaccine	Virus disease	rs210359-A	Research Support, N.I.H., Extramural
14	61308337	rs6573333	T	G	rs6573333	22610502	3.00E-10	EA	NA	NA	Up to 512 European ancestry individuals; up to 199 African American individuals	African American(199)	European(512)	ALL(711)	AFR(199)	EUR(512)	ALL(711)	Immune reponse to smallpox (secreted IFN-alpha)	HPOID:0005368	Abnormality of humoral immunity	DOID:8736	smallpox	D012899	Smallpox	EFOID:0004873	response to vaccine	Virus disease	rs6573333-A	Research Support, N.I.H., Extramural
14	72350212	rs10138587	C	T	rs10138587	22661280	3.18E-08	NA	NA	NA	537 European ancestry individuals; 207 African American individuals	African American(207)	European(537)	ALL(744)	AFR(207)	EUR(537)	ALL(744)	CD8+ T cell IFN-gamma response to smallpox vaccine	HPOID:0005368	Abnormality of humoral immunity	DOID:8736	smallpox	NA	NA	NA	NA	Virus disease	NA	Research Support, N.I.H., Extramural
14	98463157	rs7140601	T	C	rs7140601	22542470	7.00E-07	NA	NA	NA	217 African American ancestry individuals; 580 European ancestry individuals; 217 Hispanic ancestry individuals	European(580)	African American(217)	Hispanic(217)	ALL(1014)	HIS(217)	AFR(217)	EUR(580)	ALL(1014)	Immune response to smallpox vaccine (IL-6)	HPOID:0005368	Abnormality of humoral immunity	DOID:8736	smallpox	D012899	Smallpox	EFOID:0004873	response to vaccine	Virus disease
15	25894658	rs6576443	C	T	rs6576443	22610502	6.00E-09	NA	NA	NA	Up to 512 European ancestry individuals; up to 199 African American individuals	African American(199)	European(512)	ALL(711)	AFR(199)	EUR(512)	ALL(711)	Immune reponse to smallpox (secreted IFN-alpha)	HPOID:0005368	Abnormality of humoral immunity	DOID:8736	smallpox	D012899	Smallpox	EFOID:0004873	response to vaccine	Virus disease	rs6576443-A	Research Support, N.I.H., Extramural
15	54868668	rs2553218	G	T	rs2553218	22542470	8.00E-07	NA	NA	NA	217 African American ancestry individuals; 580 European ancestry individuals; 217 Hispanic ancestry individuals	European(580)	African American(217)	Hispanic(217)	ALL(1014)	HIS(217)	AFR(217)	EUR(580)	ALL(1014)	Immune response to smallpox vaccine (IL-6)	HPOID:0005368	Abnormality of humoral immunity	DOID:8736	smallpox	D012899	Smallpox	EFOID:0004873	response to vaccine	Virus disease
15	81001278	rs12148329	T	G	rs12148329	22542470	9.00E-07	NA	NA	NA	217 African American ancestry individuals; 580 European ancestry individuals; 217 Hispanic ancestry individuals	European(580)	African American(217)	Hispanic(217)	ALL(1014)	HIS(217)	AFR(217)	EUR(580)	ALL(1014)	Immune response to smallpox vaccine (IL-6)	HPOID:0005368	Abnormality of humoral immunity	DOID:8736	smallpox	D012899	Smallpox	EFOID:0004873	response to vaccine	Virus disease
16	21113272	rs16970881	G	A	rs16970881	22610502	1.00E-07	NA	NA	NA	Up to 512 European ancestry individuals; up to 199 African American individuals	African American(199)	European(512)	ALL(711)	AFR(199)	EUR(512)	ALL(711)	Immune reponse to smallpox (secreted IL-10)	HPOID:0005368	Abnormality of humoral immunity	DOID:8736	smallpox	D012899	Smallpox	EFOID:0004645	cytokine measurement	Virus disease	rs16970881-A	Research Support, N.I.H., Extramural
17	15826021	rs859267	A	C	rs859267	22610502	3.00E-07	NA	NA	NA	Up to 512 European ancestry individuals; up to 199 African American individuals	African American(199)	European(512)	ALL(711)	AFR(199)	EUR(512)	ALL(711)	Immune reponse to smallpox (secreted IL-12p40)	HPOID:0005368	Abnormality of humoral immunity	DOID:8736	smallpox	D012899	Smallpox	EFOID:0004873	response to vaccine	Virus disease	rs859267-C	Research Support, N.I.H., Extramural
17	47566312	rs16948200	G	A	rs16948200	22610502	2.00E-08	NA	NA	NA	Up to 512 European ancestry individuals; up to 199 African American individuals	African American(199)	European(512)	ALL(711)	AFR(199)	EUR(512)	ALL(711)	Immune reponse to smallpox (secreted IL-2)	HPOID:0005368	Abnormality of humoral immunity	DOID:8736	smallpox	D012899	Smallpox	EFOID:0004645	cytokine measurement	Virus disease	rs16948200-A	Research Support, N.I.H., Extramural
17	58966538	rs7224438	T	C	rs7224438	22610502	4.00E-07	NA	NA	NA	Up to 512 European ancestry individuals; up to 199 African American individuals	African American(199)	European(512)	ALL(711)	AFR(199)	EUR(512)	ALL(711)	Immune reponse to smallpox (secreted IL-2)	HPOID:0005368	Abnormality of humoral immunity	DOID:8736	smallpox	D012899	Smallpox	EFOID:0004645	cytokine measurement	Virus disease	rs7224438-G	Research Support, N.I.H., Extramural
18	12550747	rs1940973	T	C	rs1940973	22542470	8.00E-07	NA	NA	NA	217 African American ancestry individuals; 580 European ancestry individuals; 217 Hispanic ancestry individuals	European(580)	African American(217)	Hispanic(217)	ALL(1014)	HIS(217)	AFR(217)	EUR(580)	ALL(1014)	Immune response to smallpox vaccine (IL-6)	HPOID:0005368	Abnormality of humoral immunity	DOID:8736	smallpox	D012899	Smallpox	EFOID:0004873	response to vaccine	Virus disease
18	12606463	rs9959145	G	T	rs9959145	22542470	3.00E-08	NA	NA	NA	217 African American ancestry individuals; 580 European ancestry individuals; 217 Hispanic ancestry individuals	European(580)	African American(217)	Hispanic(217)	ALL(1014)	HIS(217)	AFR(217)	EUR(580)	ALL(1014)	Immune response to smallpox vaccine (IL-6)	HPOID:0005368	Abnormality of humoral immunity	DOID:8736	smallpox	D012899	Smallpox	EFOID:0004873	response to vaccine	Virus disease
18	48524161	rs9807334	G	A	rs9807334	22610502	2.00E-07	NA	NA	NA	Up to 512 European ancestry individuals; up to 199 African American individuals	African American(199)	European(512)	ALL(711)	AFR(199)	EUR(512)	ALL(711)	Immune reponse to smallpox (secreted IFN-alpha)	HPOID:0005368	Abnormality of humoral immunity	DOID:8736	smallpox	D012899	Smallpox	EFOID:0004873	response to vaccine	Virus disease	rs9807334-A	Research Support, N.I.H., Extramural
18	48713040	rs8096445	C	T	rs8096445	22610502	9.00E-09	NA	NA	NA	Up to 512 European ancestry individuals; 199 African American individuals	African American(199)	European(512)	ALL(711)	AFR(199)	EUR(512)	ALL(711)	Immune response to smallpox vaccine (IL-6)	HPOID:0005368	Abnormality of humoral immunity	DOID:8736	smallpox	D012899	Smallpox	EFOID:0004873	response to vaccine	Virus disease	rs8096445-A	Research Support, N.I.H., Extramural
19	52455249	rs1549932	G	A	rs1549932	22661280	0.000000308	NA	NA	NA	537 European ancestry individuals; 207 African American individuals	African American(207)	European(537)	ALL(744)	AFR(207)	EUR(537)	ALL(744)	CD8+ T cell IFN-gamma response to smallpox vaccine	HPOID:0005368	Abnormality of humoral immunity	DOID:8736	smallpox	NA	NA	NA	NA	Virus disease	NA	Research Support, N.I.H., Extramural
19	56451049	rs2043599	A	G	rs2043599	22610502	5.00E-07	NA	NA	NA	Up to 512 European ancestry individuals; up to 199 African American individuals	African American(199)	European(512)	ALL(711)	AFR(199)	EUR(512)	ALL(711)	Immune reponse to smallpox (secreted IFN-alpha)	HPOID:0005368	Abnormality of humoral immunity	DOID:8736	smallpox	D012899	Smallpox	EFOID:0004873	response to vaccine	Virus disease	rs2043599-G	Research Support, N.I.H., Extramural
20	1995534	rs6081597	A	G	rs6081597	22542470	7.00E-07	NA	NA	NA	217 African American ancestry individuals; 580 European ancestry individuals; 217 Hispanic ancestry individuals	European(580)	African American(217)	Hispanic(217)	ALL(1014)	HIS(217)	AFR(217)	EUR(580)	ALL(1014)	Immune response to smallpox vaccine (IL-6)	HPOID:0005368	Abnormality of humoral immunity	DOID:8736	smallpox	D012899	Smallpox	EFOID:0004873	response to vaccine	Virus disease
20	4225573	rs6052456	C	T	rs6052456	22661280	0.000000375	NA	NA	NA	537 European ancestry individuals; 207 African American individuals	African American(207)	European(537)	ALL(744)	AFR(207)	EUR(537)	ALL(744)	CD8+ T cell IFN-gamma response to smallpox vaccine	HPOID:0005368	Abnormality of humoral immunity	DOID:8736	smallpox	NA	NA	NA	NA	Virus disease	NA	Research Support, N.I.H., Extramural
21	36238507	rs2834655	G	A	rs2834655	22542470	5.00E-07	NA	NA	NA	217 African American ancestry individuals; 580 European ancestry individuals; 217 Hispanic ancestry individuals	European(580)	African American(217)	Hispanic(217)	ALL(1014)	HIS(217)	AFR(217)	EUR(580)	ALL(1014)	Immune response to smallpox vaccine (IL-6)	HPOID:0005368	Abnormality of humoral immunity	DOID:8736	smallpox	D012899	Smallpox	EFOID:0004873	response to vaccine	Virus disease
21	40314704	rs2836770	A	G	rs2836770	22542470	3.00E-06	NA	NA	NA	217 African American ancestry individuals; 580 European ancestry individuals; 217 Hispanic ancestry individuals	European(580)	African American(217)	Hispanic(217)	ALL(1014)	HIS(217)	AFR(217)	EUR(580)	ALL(1014)	Immune response to smallpox vaccine (IL-6)	HPOID:0005368	Abnormality of humoral immunity	DOID:8736	smallpox	D012899	Smallpox	EFOID:0004873	response to vaccine	Virus disease
21	47165429	rs8127571	A	G	rs8127571	22610502	2.00E-07	NA	NA	NA	Up to 512 European ancestry individuals; up to 199 African American individuals	African American(199)	European(512)	ALL(711)	AFR(199)	EUR(512)	ALL(711)	Immune reponse to smallpox (secreted IFN-alpha)	HPOID:0005368	Abnormality of humoral immunity	DOID:8736	smallpox	D012899	Smallpox	EFOID:0004873	response to vaccine	Virus disease	rs8127571-A	Research Support, N.I.H., Extramural
22	23644794	rs9608102	C	T	rs9608102	22542470	8.00E-06	NA	NA	NA	217 African American ancestry individuals; 580 European ancestry individuals; 217 Hispanic ancestry individuals	European(580)	African American(217)	Hispanic(217)	ALL(1014)	HIS(217)	AFR(217)	EUR(580)	ALL(1014)	Immune response to smallpox vaccine (IL-6)	HPOID:0005368	Abnormality of humoral immunity	DOID:8736	smallpox	D012899	Smallpox	EFOID:0004873	response to vaccine	Virus disease
22	34889097	rs738968	T	G	rs738968	22610502	8.00E-08	NA	NA	NA	Up to 512 European ancestry individuals; up to 199 African American individuals	African American(199)	European(512)	ALL(711)	AFR(199)	EUR(512)	ALL(711)	Immune reponse to smallpox (secreted TNF-alpha)	HPOID:0005368	Abnormality of humoral immunity	DOID:8736	smallpox	D012899	Smallpox	EFOID:0004645	cytokine measurement	Virus disease	rs738968-C	Research Support, N.I.H., Extramural
22	49812502	rs17000918	C	A	rs17000918	22610502	4.00E-09	NA	NA	NA	Up to 512 European ancestry individuals; up to 199 African American individuals	African American(199)	European(512)	ALL(711)	AFR(199)	EUR(512)	ALL(711)	Immune reponse to smallpox (secreted IL-1beta)	HPOID:0005368	Abnormality of humoral immunity	DOID:8736	smallpox	D012899	Smallpox	EFOID:0004645	cytokine measurement	Virus disease	rs17000918-A	Research Support, N.I.H., Extramural
X	22148051	rs1540283	C	T	rs1540283	22610502	9.00E-09	NA	NA	NA	Up to 512 European ancestry individuals; up to 199 African American individuals	African American(199)	European(512)	ALL(711)	AFR(199)	EUR(512)	ALL(711)	Immune reponse to smallpox (secreted IFN-alpha)	HPOID:0005368	Abnormality of humoral immunity	DOID:8736	smallpox	D012899	Smallpox	EFOID:0004873	response to vaccine	Virus disease	rs1540283-G	Research Support, N.I.H., Extramural
X	23383444	rs5925760	G	A	rs5925760	22610502	1.00E-07	NA	NA	NA	Up to 512 European ancestry individuals; up to 199 African American individuals	African American(199)	European(512)	ALL(711)	AFR(199)	EUR(512)	ALL(711)	Immune reponse to smallpox (secreted IFN-alpha)	HPOID:0005368	Abnormality of humoral immunity	DOID:8736	smallpox	D012899	Smallpox	EFOID:0004873	response to vaccine	Virus disease	rs5925760-A	Research Support, N.I.H., Extramural
X	97864354	rs4827947	T	C	rs4827947	22610502	3.00E-07	NA	NA	NA	Up to 512 European ancestry individuals; up to 199 African American individuals	African American(199)	European(512)	ALL(711)	AFR(199)	EUR(512)	ALL(711)	Immune reponse to smallpox (secreted IL-1beta)	HPOID:0005368	Abnormality of humoral immunity	DOID:8736	smallpox	D012899	Smallpox	EFOID:0004645	cytokine measurement	Virus disease	rs4827947-A	Research Support, N.I.H., Extramural
X	114879876	rs10218219	G	A	rs10218219	22661280	6.92E-08	NA	NA	NA	537 European ancestry individuals; 207 African American individuals	African American(207)	European(537)	ALL(744)	AFR(207)	EUR(537)	ALL(744)	CD8+ T cell IFN-gamma response to smallpox vaccine	HPOID:0005368	Abnormality of humoral immunity	DOID:8736	smallpox	NA	NA	NA	NA	Virus disease	NA	Research Support, N.I.H., Extramural
X	124073662	rs7060947	A	G	rs7060947	22610502	1.00E-07	NA	NA	NA	Up to 512 European ancestry individuals; up to 199 African American individuals	African American(199)	European(512)	ALL(711)	AFR(199)	EUR(512)	ALL(711)	Immune reponse to smallpox (secreted IFN-alpha)	HPOID:0005368	Abnormality of humoral immunity	DOID:8736	smallpox	D012899	Smallpox	EFOID:0004873	response to vaccine	Virus disease	rs7060947-G	Research Support, N.I.H., Extramural
X	145748908	rs381365	T	G	rs381365	22610502	2.00E-12	AA	NA	NA	Up to 512 European ancestry individuals; up to 199 African American individuals	African American(199)	European(512)	ALL(711)	AFR(199)	EUR(512)	ALL(711)	Immune reponse to smallpox (secreted IFN-alpha)	HPOID:0005368	Abnormality of humoral immunity	DOID:8736	smallpox	D012899	Smallpox	EFOID:0004873	response to vaccine	Virus disease	rs381365-A	Research Support, N.I.H., Extramural
X	149635295	rs17252936	A	G	rs17252936	22610502	6.00E-10	AA	NA	NA	Up to 512 European ancestry individuals; up to 199 African American individuals	African American(199)	European(512)	ALL(711)	AFR(199)	EUR(512)	ALL(711)	Immune reponse to smallpox (secreted IFN-alpha)	HPOID:0005368	Abnormality of humoral immunity	DOID:8736	smallpox	D012899	Smallpox	EFOID:0004873	response to vaccine	Virus disease	rs17252936-G	Research Support, N.I.H., Extramural

Mapped by lexical matching(Total Items:1)
HP ID	HP Name	MP ID	MP Name	Annotation
HP:0002671	Basal cell carcinoma	MP:0004207	increased squamous cell carcinoma incidence;HP:0001892	Abnormal bleeding

Mapped by homologous gene(Total Items:1)
HP ID	HP Name	MP ID	MP Name	Annotation
HP:0002671	Basal cell carcinoma	MP:0009873	abnormal aorta tunica media morphology;HP:0001892	Abnormal bleeding

Chemical(Total Drugs:0)
(Waiting for update.)

FDA approved drug and dosage information(Total Drugs:0)
(Waiting for update.)

FDA labeling changes(Total Drugs:0)
(Waiting for update.)