PedAM

Pediatric Disease Annotations & Medicines


	sleeping sickness

Disease ID	1071
Disease	sleeping sickness
Definition	A disease endemic among people and animals in Central Africa. It is caused by various species of trypanosomes, particularly T. gambiense and T. rhodesiense. Its second host is the TSETSE FLY. Involvement of the central nervous system produces "African sleeping sickness." Nagana is a rapidly fatal trypanosomiasis of horses and other animals.
Synonym	[x]african trypanosomiasis, unspecified [x]african trypanosomiasis, unspecified (disorder) african sickness sleeping african sleeping sickness african sleeping sicknesses african trypanosoma nos african trypanosomiases african trypanosomiasis african trypanosomiasis (disorder) african trypanosomiasis nos african trypanosomiasis nos (disorder) african trypanosomiasis, unspecified maladie du sommeil schlafkrankheit sickness sleeping sickness, african sleeping sicknesses, african sleeping sleeping sickness nos sleeping sickness, african sleeping sickness, nos sleeping sicknesses, african trypanosomiases, african trypanosomiasis, african trypanosomiasis, african [disease/finding]
Orphanet	ORPHANET:3385
DOID	DOID:10112
ICD10	ICD10CM:B56.9
UMLS	C0041228
MeSH	D014353
SNOMED-CT	SNOMEDCT_US_2016_09_01:27031003
Comorbidity	UMLS \| Disease \| Sentences' Count(Total Sentences:6) C0041228 \| african sleeping sickness \| 47 C0041227 \| trypanosomiasis \| 6 C0022658 \| kidney disease \| 1 C0024530 \| malaria \| 1 C0011881 \| diabetic kidney disease \| 1 C0041234 \| chagas disease \| 1
Curated Gene	(Waiting for update.)
Inferring Gene	Entrez_id \| Symbol \| Resource(Total Genes:2) 3586 \| IL10 \| infer 7124 \| TNF \| infer
Text Mined Gene	Entrez_id \| Symbol \| Score \| Resource(Total Genes:227) 1595 \| CYP51A1 \| DISEASES 11345 \| GABARAPL2 \| DISEASES 6793 \| STK10 \| DISEASES 1361 \| CPB2 \| DISEASES 359 \| AQP2 \| DISEASES 4504 \| MT3 \| DISEASES 990 \| CDC6 \| DISEASES 11274 \| USP18 \| DISEASES 4627 \| MYH9 \| DISEASES 158 \| ADSL \| DISEASES 64841 \| GNPNAT1 \| DISEASES 128869 \| PIGU \| DISEASES 2222 \| FDFT1 \| DISEASES 1666 \| DECR1 \| DISEASES 7991 \| TUSC3 \| DISEASES 26330 \| GAPDHS \| DISEASES 1124 \| CHN2 \| DISEASES 59 \| ACTA2 \| DISEASES 6348 \| CCL3 \| DISEASES 9487 \| PIGL \| DISEASES 1362 \| CPD \| DISEASES 173 \| AFM \| DISEASES 3558 \| IL2 \| DISEASES 3458 \| IFNG \| DISEASES 2597 \| GAPDH \| DISEASES 9168 \| TMSB10 \| DISEASES 4953 \| ODC1 \| DISEASES 10352 \| WARS2 \| DISEASES 10560 \| SLC19A2 \| DISEASES 335 \| APOA1 \| DISEASES 9519 \| TBPL1 \| DISEASES 2745 \| GLRX \| DISEASES 9409 \| PEX16 \| DISEASES 27019 \| DNAI1 \| DISEASES 84329 \| HVCN1 \| DISEASES 79441 \| HAUS3 \| DISEASES 5740 \| PTGIS \| DISEASES 22933 \| SIRT2 \| DISEASES 83861 \| RSPH3 \| DISEASES 55902 \| ACSS2 \| DISEASES 3337 \| DNAJB1 \| DISEASES 4677 \| NARS \| DISEASES 3569 \| IL6 \| DISEASES 4836 \| NMT1 \| DISEASES 56886 \| UGGT1 \| DISEASES 5004 \| ORM1 \| DISEASES 2766 \| GMPR \| DISEASES 23317 \| DNAJC13 \| DISEASES 2581 \| GALC \| DISEASES 16 \| AARS \| DISEASES 338917 \| VSX2 \| DISEASES 4141 \| MARS \| DISEASES 5289 \| PIK3C3 \| DISEASES 55149 \| MTPAP \| DISEASES 3552 \| IL1A \| DISEASES 3553 \| IL1B \| DISEASES 440275 \| EIF2AK4 \| DISEASES 3938 \| LCT \| DISEASES 3383 \| ICAM1 \| DISEASES 64083 \| GOLPH3 \| DISEASES 6897 \| TARS \| DISEASES 5307 \| PITX1 \| DISEASES 23395 \| LARS2 \| DISEASES 23710 \| GABARAPL1 \| DISEASES 26277 \| TINF2 \| DISEASES 3454 \| IFNAR1 \| DISEASES 5141 \| PDE4A \| DISEASES 5226 \| PGD \| DISEASES 23432 \| GPR161 \| DISEASES 51281 \| ANKMY1 \| DISEASES 10667 \| FARS2 \| DISEASES 51604 \| PIGT \| DISEASES 79731 \| NARS2 \| DISEASES 60558 \| GUF1 \| DISEASES 8467 \| SMARCA5 \| DISEASES 7342 \| UBP1 \| DISEASES 23576 \| DDAH1 \| DISEASES 1436 \| CSF1R \| DISEASES 10563 \| CXCL13 \| DISEASES 8566 \| PDXK \| DISEASES 9551 \| ATP5J2 \| DISEASES 6352 \| CCL5 \| DISEASES 81570 \| CLPB \| DISEASES 7412 \| VCAM1 \| DISEASES 8320 \| EOMES \| DISEASES 84666 \| RETNLB \| DISEASES 1040 \| CDS1 \| DISEASES 213 \| ALB \| DISEASES 167153 \| PAPD4 \| DISEASES 222962 \| SLC29A4 \| DISEASES 360 \| AQP3 \| DISEASES 3251 \| HPRT1 \| DISEASES 3308 \| HSPA4 \| DISEASES 55699 \| IARS2 \| DISEASES 3627 \| CXCL10 \| DISEASES 118429 \| ANTXR2 \| DISEASES 2353 \| FOS \| DISEASES 64080 \| RBKS \| DISEASES 5002 \| SLC22A18 \| DISEASES 64852 \| TUT1 \| DISEASES 51172 \| NAGPA \| DISEASES 131450 \| CD200R1 \| DISEASES 653499 \| LGALS7B \| DISEASES 8542 \| APOL1 \| DISEASES 92609 \| TIMM50 \| DISEASES 6863 \| TAC1 \| DISEASES 205 \| AK4 \| DISEASES 2837 \| UTS2R \| DISEASES 84066 \| TEX35 \| DISEASES 9033 \| PKD2L1 \| DISEASES 10250 \| SRRM1 \| DISEASES 8454 \| CUL1 \| DISEASES 4843 \| NOS2 \| DISEASES 6906 \| SERPINA7 \| DISEASES 342184 \| FMN1 \| DISEASES 3320 \| HSP90AA1 \| DISEASES 1984 \| EIF5A \| DISEASES 225689 \| MAPK15 \| DISEASES 51477 \| ISYNA1 \| DISEASES 200162 \| SPAG17 \| DISEASES 123283 \| TARSL2 \| DISEASES 57496 \| MKL2 \| DISEASES 55171 \| TBCCD1 \| DISEASES 2804 \| GOLGB1 \| DISEASES 1508 \| CTSB \| DISEASES 132884 \| EVC2 \| DISEASES 124454 \| EARS2 \| DISEASES 8481 \| OFD1 \| DISEASES 3005 \| H1F0 \| DISEASES 5144 \| PDE4D \| DISEASES 79971 \| WLS \| DISEASES 1785 \| DNM2 \| DISEASES 3240 \| HP \| DISEASES 91137 \| SLC25A46 \| DISEASES 85301 \| COL27A1 \| DISEASES 2224 \| FDPS \| DISEASES 26151 \| NAT9 \| DISEASES 51592 \| TRIM33 \| DISEASES 2013 \| EMP2 \| DISEASES 7037 \| TFRC \| DISEASES 3135 \| HLA-G \| DISEASES 58484 \| NLRC4 \| DISEASES 8532 \| CPZ \| DISEASES 4512 \| MT-CO1 \| DISEASES 4519 \| MT-CYB \| DISEASES 4536 \| MT-ND2 \| DISEASES 9937 \| DCLRE1A \| DISEASES 23038 \| WDTC1 \| DISEASES 8564 \| KMO \| DISEASES 6580 \| SLC22A1 \| DISEASES 10440 \| TIMM17A \| DISEASES 51022 \| GLRX2 \| DISEASES 51744 \| CD244 \| DISEASES 911 \| CD1C \| DISEASES 912 \| CD1D \| DISEASES 262 \| AMD1 \| DISEASES 6944 \| VPS72 \| DISEASES 11231 \| SEC63 \| DISEASES 80222 \| TARS2 \| DISEASES 5550 \| PREP \| DISEASES 57038 \| RARS2 \| DISEASES 4199 \| ME1 \| DISEASES 6319 \| SCD \| DISEASES 2959 \| GTF2B \| DISEASES 4923 \| NTSR1 \| DISEASES 959 \| CD40LG \| DISEASES 10026 \| PIGK \| DISEASES 6594 \| SMARCA1 \| DISEASES 8480 \| RAE1 \| DISEASES 377841 \| ENTPD8 \| DISEASES 5770 \| PTPN1 \| DISEASES 26301 \| GBGT1 \| DISEASES 1503 \| CTPS1 \| DISEASES 6418 \| SET \| DISEASES 1759 \| DNM1 \| DISEASES 5464 \| PPA1 \| DISEASES 2170 \| FABP3 \| DISEASES 1104 \| RCC1 \| DISEASES 253430 \| IPMK \| DISEASES 164091 \| PAQR7 \| DISEASES 2582 \| GALE \| DISEASES 7295 \| TXN \| DISEASES 6135 \| RPL11 \| DISEASES 23564 \| DDAH2 \| DISEASES 7917 \| BAG6 \| DISEASES 8428 \| STK24 \| DISEASES 9576 \| SPAG6 \| DISEASES 6723 \| SRM \| DISEASES 3963 \| LGALS7 \| DISEASES 2710 \| GK \| DISEASES 50808 \| AK3 \| DISEASES 7306 \| TYRP1 \| DISEASES 10716 \| TBR1 \| DISEASES 54903 \| MKS1 \| DISEASES 51520 \| LARS \| DISEASES 3652 \| IPP \| DISEASES 594857 \| NPS \| DISEASES 344807 \| CD200R1L \| DISEASES 4905 \| NSF \| DISEASES 3098 \| HK1 \| DISEASES 60489 \| APOBEC3G \| DISEASES 7018 \| TF \| DISEASES 196385 \| DNAH10 \| DISEASES 501 \| ALDH7A1 \| DISEASES 522 \| ATP5J \| DISEASES 10478 \| SLC25A17 \| DISEASES 113235 \| SLC46A1 \| DISEASES 57545 \| CC2D2A \| DISEASES 7124 \| TNF \| DISEASES 9732 \| DOCK4 \| DISEASES 9278 \| ZBTB22 \| DISEASES 2821 \| GPI \| DISEASES 3586 \| IL10 \| DISEASES 58155 \| PTBP2 \| DISEASES 8833 \| GMPS \| DISEASES 8760 \| CDS2 \| DISEASES 6207 \| RPS13 \| DISEASES 4190 \| MDH1 \| DISEASES 57176 \| VARS2 \| DISEASES 51271 \| UBAP1 \| DISEASES 3250 \| HPR \| DISEASES 5756 \| TWF1 \| DISEASES 8914 \| TIMELESS \| DISEASES 1506 \| CTRL \| DISEASES 11201 \| POLI \| DISEASES 7955 \| RNF217-AS1 \| DISEASES 26806 \| SNORD44 \| DISEASES
Locus	(Waiting for update.)

Disease ID	1071
Disease	sleeping sickness
Integrated Phenotype	(Waiting for update.)
Text Mined Phenotype	(Waiting for update.)

Disease ID	1071
Disease	sleeping sickness
Manually Symptom	(Waiting for update.)
Text Mined Symptom	UMLS \| Name \| Sentences' Count(Total Symptoms:1) C0752303 \| urological manifestations \| 1

Manually Genotype(Total Text Mining Genotypes:0)
(Waiting for update.)

All Snps(Total Genotypes:0)
(Waiting for update.)

GWASdb Annotation(Total Genotypes:0)
(Waiting for update.)

GWASdb Snp Trait(Total Genotypes:0)
(Waiting for update.)

Mapped by lexical matching(Total Items:0)
(Waiting for update.)

Mapped by homologous gene(Total Items:0)
(Waiting for update.)

Chemical(Total Drugs:1)
CUI	ChemicalName	ChemicalID	CasRN	DiseaseName	DiseaseID	DirectEvidence	PubMedIDs
C0041228	miltefosine	C039128	-	trypanosomiasis, african	MESH:D014353	therapeutic	9107362

FDA approved drug and dosage information(Total Drugs:0)
(Waiting for update.)

FDA labeling changes(Total Drugs:0)
(Waiting for update.)

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