PedAM

Pediatric Disease Annotations & Medicines


	sickle cell anemia

Disease ID	17
Disease	sickle cell anemia
Definition	A disease characterized by chronic hemolytic anemia, episodic painful crises, and pathologic involvement of many organs. It is the clinical expression of homozygosity for hemoglobin S.
Synonym	anaemia cell sickle anemia cell disorder sickle anemia cell disorders sickle anemia cells sickle anemia cells sickles anemia sickle cell anemia sickle celled anemia sickle-cell anemia, sickle cell anemia, sickle cell [disease/finding] anemias, sickle cell cell disease, sickle cell diseases sickle cell diseases, sickle cell disorder sickle cell disorder, sickle cell disorders, sickle cell sickle syndrome cell sickle syndromes cells disease sickle disease hb s disease sickle cell disease sickle-cell disease, hemoglobin s drepanocythaemia drepanocythemia haemoglobin s disease haemoglobin s-s disease hb s disease hb ss hb ss disease hbs disease hemoglobin s dis hemoglobin s disease hemoglobin s disease (disorder) hemoglobin s diseases hemoglobin s-s disease hemoglobin ss hemoglobin ss disease hereditary hemoglobinopathy disorder homozygous for hemoglobin s hereditary hemoglobinopathy disorder homozygous for hemoglobin s (disorder) herrick syndrome herrick's anemia scd scds sickle cell (ss only) sickle cell anaemia sickle cell anaemia (disorder) sickle cell anaemia nos sickle cell anaemia of unspecified type sickle cell anemia nos sickle cell anemia nos (disorder) sickle cell anemia of unspecified type sickle cell anemia of unspecified type (disorder) sickle cell anemias sickle cell disease sickle cell disease nos sickle cell diseases sickle cell disorder sickle cell disorders sickle cell hemolytic anemia sickle cell syndrome sickle cell syndrome (disorder) sickle-cell anaemia sickle-cell anemia sickle-cell anemia nos sickle-cell disease sickle-cell disease, unspecified sicklemia sickling disorder due to haemoglobin s sickling disorder due to hemoglobin s sickling disorder due to hemoglobin s (disorder) syndrome sickle cell
Orphanet	ORPHANET:232
OMIM	OMIM:603903 OMIM:604031
DOID	DOID:10923
UMLS	C0002895
MeSH	D000755
SNOMED-CT	SNOMEDCT_US_2016_09_01:127040003;SNOMEDCT_US_2016_09_01:417357006
Comorbidity	UMLS \| Disease \| Sentences' Count(Total Sentences:138) C0742343 \| acute chest syndrome \| 24 C0020538 \| hypertension \| 24 C0020542 \| pulmonary hypertension \| 23 C0948201 \| alloimmunization \| 21 C0282193 \| iron overload \| 16 C0033117 \| priapism \| 15 C0029443 \| osteomyelitis \| 11 C0004096 \| asthma \| 8 C0002871 \| anemia \| 6 C0007785 \| cerebral infarct \| 5 C0004623 \| bacterial infection \| 4 C0398623 \| hypercoagulable state \| 4 C0042373 \| vascular disease \| 4 C0024530 \| malaria \| 4 C0039730 \| thalassemia \| 4 C0022658 \| kidney disease \| 3 C0033687 \| proteinuria \| 3 C0040053 \| thrombosis \| 3 C0003864 \| arthritis \| 3 C0008350 \| gallstones \| 3 C0037998 \| splenic infarction \| 3 C0039730 \| thalassemias \| 2 C0679466 \| cognitive deficits \| 2 C0022658 \| renal disease \| 2 C0007785 \| cerebral infarction \| 2 C0026654 \| moyamoya syndrome \| 2 C0042870 \| vitamin d deficiency \| 2 C1260402 \| splenic sequestration \| 2 C0007766 \| intracranial aneurysms \| 2 C0018784 \| sensorineural hearing loss \| 2 C0153500 \| heart ca \| 2 C0006142 \| breast cancer \| 2 C0398623 \| hypercoagulability \| 2 C0032285 \| pneumonia \| 2 C1619734 \| pulmonary arterial hypertension \| 2 C0021400 \| influenza \| 2 C0026975 \| myelitis \| 2 C0007766 \| cranial aneurysm \| 2 C0019196 \| hepatitis c \| 2 C0852949 \| arterial disease \| 2 C0032269 \| pneumococcal infection \| 2 C0007785 \| cerebral infarcts \| 2 C0008350 \| cholelithiasis \| 2 C0007766 \| intracranial aneurysm \| 2 C0011847 \| diabetes \| 2 C0011570 \| depression \| 2 C0022661 \| end-stage renal disease \| 2 C0007273 \| carotid artery disease \| 2 C0042870 \| vitamin d defic \| 2 C0002871 \| anaemia \| 2 C0004623 \| bacterial infections \| 2 C0242350 \| erectile dysfunction \| 2 C0026654 \| moyamoya disease \| 1 C0002878 \| hemolytic anemia \| 1 C0040188 \| tic disorders \| 1 C0024115 \| lung disease \| 1 C0022661 \| end-stage kidney disease \| 1 C0020581 \| hyphema \| 1 C0014118 \| endocarditis \| 1 C0011882 \| diabetic neuropathy \| 1 C0007273 \| carotid arterial disease \| 1 C0036117 \| salmonella infect \| 1 C0023895 \| liver disease \| 1 C0001623 \| adrenal insufficiency \| 1 C0016522 \| patent foramen ovale \| 1 C0001261 \| actinomycosis \| 1 C0026985 \| myelodysplasia \| 1 C0019021 \| hemoglobin c disease \| 1 C0011854 \| type 1 diabetes mellitus \| 1 C0022408 \| arthropathy \| 1 C0014544 \| epilepsy \| 1 C0206693 \| medullary carcinoma \| 1 C0035302 \| retinal artery occlusion \| 1 C0019158 \| hepatitis \| 1 C0302592 \| cervical ca \| 1 C0038220 \| status epilepticus \| 1 C1258215 \| ileus \| 1 C0020532 \| hypersplenism \| 1 C0018799 \| heart disease \| 1 C0030305 \| pancreatitis \| 1 C0037315 \| sleep-disordered breathing \| 1 C0027726 \| nephrotic syndrome \| 1 C0392041 \| testicular infarction \| 1 C0011849 \| diabetes mellitus \| 1 C0029882 \| otitis media \| 1 C0155877 \| atopic asthma \| 1 C0008372 \| intrahepatic cholestasis \| 1 C0014761 \| haemolytic disease of the newborn \| 1 C0019360 \| zoster \| 1 C0022667 \| papillary necrosis \| 1 C0016053 \| fibromyalgia \| 1 C0008049 \| varicella \| 1 C0004659 \| bacteriuria \| 1 C0013575 \| ectodermal dysplasia \| 1 C0029434 \| osteogenesis imperfecta \| 1 C0032285 \| pneumoniae \| 1 C0155765 \| microangiopathy \| 1 C0392041 \| testicular infarct \| 1 C0034065 \| pulmonary embolism \| 1 C0004936 \| mental disorders \| 1 C0553662 \| juvenile idiopathic arthritis \| 1 C1565489 \| renal insufficiency \| 1 C0003874 \| septic arthritis \| 1 C0033845 \| pseudotumor cerebri \| 1 C0751955 \| brain infarct \| 1 C0042075 \| urologic disease \| 1 C0085681 \| hyperphosphatemia \| 1 C0024141 \| systemic lupus erythematosus \| 1 C0024143 \| lupus nephritis \| 1 C0040961 \| tricuspid regurgitation \| 1 C0035302 \| retinal artery occlusions \| 1 C0022116 \| ischemia \| 1 C0026986 \| myelodysplastic syndrome \| 1 C0002895 \| sickle cell anemia \| 1 C0006123 \| branch retinal artery occlusion \| 1 C0026654 \| moyamoya \| 1 C0008370 \| cholestasis \| 1 C0029463 \| osteosarcoma \| 1 C0027697 \| nephritis \| 1 C0206062 \| interstitial lung disease \| 1 C0026764 \| multiple myeloma \| 1 C0040053 \| thrombus \| 1 C0520679 \| obstructive sleep apnea \| 1 C0036117 \| salmonella infections \| 1 C0162429 \| malnutrition \| 1 C0037315 \| sleep apnea \| 1 C0011854 \| type 1 diabetes \| 1 C0042769 \| virus infection \| 1 C0701818 \| choledocholithiasis \| 1 C0036117 \| salmonella infection \| 1 C0149931 \| migraine \| 1 C0020619 \| hypogonadism \| 1 C0442874 \| neuropathy \| 1 C0409974 \| lupus erythematosus \| 1 C0162429 \| undernutrition \| 1 C0005283 \| beta thalassemia \| 1 C0007134 \| renal carcinoma \| 1 C0751955 \| brain infarction \| 1
Curated Gene	Entrez_id \| Symbol \| Resource(Total Genes:11) TNF \| 7124 \| CTD_human VCAM1 \| 7412 \| CTD_human HBB \| 3043 \| CLINVAR;CTD_human;ORPHANET;UNIPROT DHODH \| 1723 \| CTD_human HP \| 3240 \| CTD_human BCL11A \| 53335 \| GWASCAT NPPB \| 4879 \| CTD_human CAD \| 790 \| CTD_human UMPS \| 7372 \| CTD_human SCD \| 6319 \| OMIM NPRL3 \| 8131 \| GWASCAT
Inferring Gene	Entrez_id \| Symbol \| Resource(Total Genes:37) 338 \| APOB \| infer 50617 \| ATP6V0A4 \| infer 135152 \| B3GAT2 \| infer 1565 \| CYP2D6 \| infer 2824 \| GPM6B \| infer 3043 \| HBB \| infer 10767 \| HBS1L \| infer 9424 \| KCNK6 \| infer 4153 \| MBL2 \| infer 4163 \| MCC \| infer 4602 \| MYB \| infer 8654 \| PDE5A \| infer 5251 \| PHEX \| infer 56681 \| SAR1A \| infer 344988 \| SAR1AP3 \| infer 9760 \| TOX \| infer 6737 \| TRIM21 \| infer 54658 \| UGT1A1 \| infer 54575 \| UGT1A10 \| infer 54659 \| UGT1A3 \| infer 54657 \| UGT1A4 \| infer 54579 \| UGT1A5 \| infer 54578 \| UGT1A6 \| infer 54577 \| UGT1A7 \| infer 54576 \| UGT1A8 \| infer 54600 \| UGT1A9 \| infer 7364 \| UGT2B7 \| infer 64848 \| YTHDC2 \| infer 729230 \| CCR2 \| infer 1234 \| CCR5 \| infer 1906 \| EDN1 \| infer 2147 \| F2 \| infer 3119 \| HLA-DQB1 \| infer 3123 \| HLA-DRB1 \| infer 4524 \| MTHFR \| infer 4846 \| NOS3 \| infer 4842 \| NOS1 \| infer
Text Mined Gene	Entrez_id \| Symbol \| Score \| Resource(Total Genes:209) 3566 \| IL4R \| DISEASES 368 \| ABCC6 \| DISEASES 7049 \| TGFBR3 \| DISEASES 3053 \| SERPIND1 \| DISEASES 973 \| CD79A \| DISEASES 57817 \| HAMP \| DISEASES 5054 \| SERPINE1 \| DISEASES 1440 \| CSF3 \| DISEASES 4254 \| KITLG \| DISEASES 2597 \| GAPDH \| DISEASES 56920 \| SEMA3G \| DISEASES 6402 \| SELL \| DISEASES 55640 \| FLVCR2 \| DISEASES 1748 \| DLX4 \| DISEASES 92 \| ACVR2A \| DISEASES 3204 \| HOXA7 \| DISEASES 6745 \| SSR1 \| DISEASES 6779 \| STATH \| DISEASES 5199 \| CFP \| DISEASES 22879 \| MON1B \| DISEASES 2952 \| GSTT1 \| DISEASES 3040 \| HBA2 \| DISEASES 2056 \| EPO \| DISEASES 9518 \| GDF15 \| DISEASES 50617 \| ATP6V0A4 \| DISEASES 5989 \| RFX1 \| DISEASES 1401 \| CRP \| DISEASES 4907 \| NT5E \| DISEASES 3569 \| IL6 \| DISEASES 4069 \| LYZ \| DISEASES 7450 \| VWF \| DISEASES 384 \| ARG2 \| DISEASES 7224 \| TRPC5 \| DISEASES 3783 \| KCNN4 \| DISEASES 3553 \| IL1B \| DISEASES 9424 \| KCNK6 \| DISEASES 28960 \| DCPS \| DISEASES 6403 \| SELP \| DISEASES 84162 \| KIAA1109 \| DISEASES 658 \| BMPR1B \| DISEASES 3383 \| ICAM1 \| DISEASES 10661 \| KLF1 \| DISEASES 10723 \| SLC12A7 \| DISEASES 3263 \| HPX \| DISEASES 4059 \| BCAM \| DISEASES 805 \| CALM2 \| DISEASES 654 \| BMP6 \| DISEASES 6326 \| SCN2A \| DISEASES 10538 \| BATF \| DISEASES 4091 \| SMAD6 \| DISEASES 1636 \| ACE \| DISEASES 808 \| CALM3 \| DISEASES 5152 \| PDE9A \| DISEASES 4634 \| MYL3 \| DISEASES 4056 \| LTC4S \| DISEASES 3046 \| HBE1 \| DISEASES 114757 \| CYGB \| DISEASES 6352 \| CCL5 \| DISEASES 3889 \| KRT83 \| DISEASES 58191 \| CXCL16 \| DISEASES 115 \| ADCY9 \| DISEASES 6006 \| RHCE \| DISEASES 7412 \| VCAM1 \| DISEASES 27306 \| HPGDS \| DISEASES 213 \| ALB \| DISEASES 5473 \| PPBP \| DISEASES 308 \| ANXA5 \| DISEASES 3673 \| ITGA2 \| DISEASES 3562 \| IL3 \| DISEASES 1437 \| CSF2 \| DISEASES 5224 \| PGAM2 \| DISEASES 25798 \| BRI3 \| DISEASES 4846 \| NOS3 \| DISEASES 9311 \| ASIC3 \| DISEASES 282763 \| OR51B5 \| DISEASES 221092 \| HNRNPUL2 \| DISEASES 84168 \| ANTXR1 \| DISEASES 5724 \| PTAFR \| DISEASES 54578 \| UGT1A6 \| DISEASES 3726 \| JUNB \| DISEASES 3094 \| HINT1 \| DISEASES 136 \| ADORA2B \| DISEASES 54463 \| FAM134B \| DISEASES 54658 \| UGT1A1 \| DISEASES 154 \| ADRB2 \| DISEASES 51327 \| AHSP \| DISEASES 10855 \| HPSE \| DISEASES 64081 \| PBLD \| DISEASES 2147 \| F2 \| DISEASES 5340 \| PLG \| DISEASES 947 \| CD34 \| DISEASES 27115 \| PDE7B \| DISEASES 112 \| ADCY6 \| DISEASES 2944 \| GSTM1 \| DISEASES 8658 \| TNKS \| DISEASES 4778 \| NFE2 \| DISEASES 493829 \| TRIM72 \| DISEASES 653499 \| LGALS7B \| DISEASES 5062 \| PAK2 \| DISEASES 5191 \| PEX7 \| DISEASES 55109 \| AGGF1 \| DISEASES 51179 \| HAO2 \| DISEASES 2824 \| GPM6B \| DISEASES 6950 \| TCP1 \| DISEASES 8542 \| APOL1 \| DISEASES 6764 \| ST5 \| DISEASES 7182 \| NR2C2 \| DISEASES 6014 \| RIT2 \| DISEASES 3039 \| HBA1 \| DISEASES 51341 \| ZBTB7A \| DISEASES 2027 \| ENO3 \| DISEASES 1453 \| CSNK1D \| DISEASES 55553 \| SOX6 \| DISEASES 3032 \| HADHB \| DISEASES 161882 \| ZFPM1 \| DISEASES 3047 \| HBG1 \| DISEASES 79345 \| OR51B2 \| DISEASES 6401 \| SELE \| DISEASES 6007 \| RHD \| DISEASES 6297 \| SALL2 \| DISEASES 3043 \| HBB \| DISEASES 2152 \| F3 \| DISEASES 2938 \| GSTA1 \| DISEASES 3048 \| HBG2 \| DISEASES 53335 \| BCL11A \| DISEASES 2290 \| FOXG1 \| DISEASES 5313 \| PKLR \| DISEASES 7225 \| TRPC6 \| DISEASES 669 \| BPGM \| DISEASES 3386 \| ICAM4 \| DISEASES 391723 \| HELT \| DISEASES 54575 \| UGT1A10 \| DISEASES 26762 \| HAVCR1 \| DISEASES 2035 \| EPB41 \| DISEASES 3767 \| KCNJ11 \| DISEASES 3792 \| KEL \| DISEASES 7453 \| WARS \| DISEASES 3240 \| HP \| DISEASES 801 \| CALM1 \| DISEASES 1108 \| CHD4 \| DISEASES 493 \| ATP2B4 \| DISEASES 51592 \| TRIM33 \| DISEASES 55959 \| SULF2 \| DISEASES 7037 \| TFRC \| DISEASES 2993 \| GYPA \| DISEASES 6533 \| SLC6A6 \| DISEASES 5167 \| ENPP1 \| DISEASES 10724 \| MGEA5 \| DISEASES 23038 \| WDTC1 \| DISEASES 3664 \| IRF6 \| DISEASES 462 \| SERPINC1 \| DISEASES 2153 \| F5 \| DISEASES 10767 \| HBS1L \| DISEASES 910 \| CD1B \| DISEASES 959 \| CD40LG \| DISEASES 26036 \| ZNF451 \| DISEASES 953 \| ENTPD1 \| DISEASES 377841 \| ENTPD8 \| DISEASES 10564 \| ARFGEF2 \| DISEASES 1580 \| CYP4B1 \| DISEASES 100 \| ADA \| DISEASES 310 \| ANXA7 \| DISEASES 27433 \| TOR2A \| DISEASES 54576 \| UGT1A8 \| DISEASES 84890 \| ADO \| DISEASES 5592 \| PRKG1 \| DISEASES 2159 \| F10 \| DISEASES 4524 \| MTHFR \| DISEASES 2623 \| GATA1 \| DISEASES 1471 \| CST3 \| DISEASES 57704 \| GBA2 \| DISEASES 8573 \| CASK \| DISEASES 3963 \| LGALS7 \| DISEASES 646480 \| FABP9 \| DISEASES 1906 \| EDN1 \| DISEASES 54790 \| TET2 \| DISEASES 9365 \| KL \| DISEASES 390058 \| OR51B6 \| DISEASES 79339 \| OR51B4 \| DISEASES 3045 \| HBD \| DISEASES 4285 \| MIPEP \| DISEASES 83650 \| SLC35G5 \| DISEASES 201633 \| TIGIT \| DISEASES 94 \| ACVRL1 \| DISEASES 22900 \| CARD8 \| DISEASES 8131 \| NPRL3 \| DISEASES 7018 \| TF \| DISEASES 23066 \| CAND2 \| DISEASES 57468 \| SLC12A5 \| DISEASES 522 \| ATP5J \| DISEASES 3718 \| JAK3 \| DISEASES 85443 \| DCLK3 \| DISEASES 6560 \| SLC12A4 \| DISEASES 7124 \| TNF \| DISEASES 7258 \| TSPY1 \| DISEASES 100289087 \| TSPY10 \| DISEASES 3586 \| IL10 \| DISEASES 9053 \| MAP7 \| DISEASES 57553 \| MICAL3 \| DISEASES 54659 \| UGT1A3 \| DISEASES 56244 \| BTNL2 \| DISEASES 2533 \| FYB \| DISEASES 79776 \| ZFHX4 \| DISEASES 60481 \| ELOVL5 \| DISEASES 8972 \| MGAM \| DISEASES 56342 \| PPAN \| DISEASES 5228 \| PGF \| DISEASES 9990 \| SLC12A6 \| DISEASES 114780 \| PKD1L2 \| DISEASES
Locus	Symbol \| Locus(Total Locus:1) HBB \| 11p15.4

Disease ID	17
Disease	sickle cell anemia
Integrated Phenotype	HPO \| Name(Total Integrated Phenotypes:35) HP:0001891 \| Iron deficiency anemia HP:0001640 \| Increased heart size HP:0011904 \| Persistence of hemoglobin F HP:0010885 \| Aseptic necrosis HP:0001974 \| Leukocytosis HP:0011981 \| Pigment gallstones HP:0001396 \| Cholestasis HP:0004870 \| Chronic hemolytic anemia HP:0002240 \| Enlarged liver HP:0001935 \| Microcytic anemia HP:0001878 \| Hemolytic anemia HP:0005518 \| Increased mean corpuscular volume HP:0001878 \| Haemolytic anaemia HP:0200023 \| Priapism HP:0001744 \| Splenomegaly HP:0001081 \| Gallstones HP:0001931 \| Hypochromic anemia HP:0008346 \| Increased sickling of erythrocytes HP:0001894 \| Thrombocytosis HP:0000707 \| Abnormality of the nervous system HP:0100749 \| Chest pain HP:0000939 \| Osteoporosis HP:0012531 \| Pain HP:0002597 \| Abnormality of the vasculature HP:0000952 \| Yellow skin HP:0000790 \| Hematuria HP:0001743 \| Abnormality of the spleen HP:0001923 \| Reticulocytosis HP:0008282 \| Unconjugated hyperbilirubinemia HP:0002719 \| Recurrent infections HP:0012418 \| Hypoxemia HP:0000488 \| Noninflammatory retina disease HP:0003259 \| Elevated serum creatinine HP:0045040 \| Abnormal lactate dehydrogenase activity HP:0002754 \| Osteomyelitis
Text Mined Phenotype	HPO \| Name \| Sentences' Count(Total Phenotypes:124) HP:0012531 \| Pain \| 39 HP:0001297 \| Cerebral vascular events \| 32 HP:0000822 \| Hypertension \| 24 HP:0002092 \| Pulmonary artery hypertension \| 24 HP:0200023 \| Priapism \| 15 HP:0002754 \| Bone infection \| 11 HP:0001903 \| Anemia \| 8 HP:0002099 \| Asthma \| 8 HP:0010885 \| Aseptic necrosis \| 6 HP:0100310 \| Extradural hematoma \| 5 HP:0001081 \| Gallstones \| 5 HP:0012594 \| High urine albumin levels \| 5 HP:0012592 \| Albuminuria \| 4 HP:0100543 \| Cognitive deficits \| 4 HP:0001945 \| Fever \| 4 HP:0001369 \| Arthritis \| 3 HP:0012532 \| Chronic pain \| 3 HP:0002027 \| Abdominal pain \| 3 HP:0001944 \| Dehydration \| 3 HP:0001907 \| Thromboembolic disease \| 3 HP:0012418 \| Low blood oxygen level \| 3 HP:0001399 \| Liver failure \| 3 HP:0000952 \| Yellow skin \| 3 HP:0011856 \| Pica \| 3 HP:0000093 \| Proteinuria \| 3 HP:0002863 \| Myelodysplastic syndrome \| 2 HP:0000407 \| sensorineural hearing loss \| 2 HP:0003002 \| Breast carcinoma \| 2 HP:0010677 \| Enuresis nocturna \| 2 HP:0000790 \| Hematuria \| 2 HP:0004944 \| Cerebral artery aneurysm \| 2 HP:0100820 \| Glomerulopathy \| 2 HP:0000805 \| Enuresis \| 2 HP:0100749 \| Thoracic pain \| 2 HP:0100724 \| Hypercoagulability \| 2 HP:0100512 \| Vitamin D deficiency \| 2 HP:0012486 \| Inflammation of spinal cord \| 2 HP:0000802 \| Erectile dysfunction \| 2 HP:0002617 \| Aneurysmal dilatation \| 2 HP:0000716 \| Depression \| 2 HP:0003774 \| End-stage renal failure \| 2 HP:0002090 \| Pneumonia \| 2 HP:0004936 \| Blood clot in vein \| 2 HP:0002625 \| Blood clot in a deep vein \| 1 HP:0005180 \| Tricuspid insufficiency \| 1 HP:0012461 \| Bacteria in urine \| 1 HP:0030666 \| Retinal neovascularisation \| 1 HP:0001878 \| Haemolytic anaemia \| 1 HP:0000388 \| Otitis media \| 1 HP:0002076 \| Migraine headaches \| 1 HP:0003040 \| Arthropathy \| 1 HP:0002597 \| Abnormality of blood vessels \| 1 HP:0001733 \| Pancreatic inflammation \| 1 HP:0000010 \| Frequent urinary tract infections \| 1 HP:0030828 \| Wheezing \| 1 HP:0100033 \| Tic disorder \| 1 HP:0002459 \| Dysautonomia \| 1 HP:0002725 \| Systemic lupus erythematosus \| 1 HP:0002870 \| Obstructive sleep apnea \| 1 HP:0002595 \| Gastrointestinal atony \| 1 HP:0100806 \| Sepsis \| 1 HP:0002905 \| Hyperphosphatemia \| 1 HP:0009726 \| Renal neoplasm \| 1 HP:0030882 \| Enlargement of the diameter (cross-section) of a coronary artery. \| 1 HP:0003146 \| Decreased circulating cholesterol level \| 1 HP:0100758 \| Gangrene \| 1 HP:0100545 \| Arterial stenosis \| 1 HP:0002104 \| Absence of spontaneous respiration \| 1 HP:0000100 \| Nephrosis \| 1 HP:0005661 \| Salmonella osteomyelitis \| 1 HP:0002204 \| Pulmonary embolism \| 1 HP:0001941 \| acidemia \| 1 HP:0001396 \| Cholestasis \| 1 HP:0010535 \| Sleep apnea \| 1 HP:0005681 \| Juvenile idiopathic arthritis \| 1 HP:0200123 \| Chronic liver inflammation \| 1 HP:0002904 \| High blood bilirubin levels \| 1 HP:0006530 \| Interstitial lung disease \| 1 HP:0002500 \| Leukoaraiosis \| 1 HP:0001971 \| Hypersplenism \| 1 HP:0000846 \| Hypoadrenalism \| 1 HP:0000938 \| Decreased bone mineral density \| 1 HP:0011886 \| Hyphema \| 1 HP:0003095 \| Septic arthritis \| 1 HP:0001714 \| Ventricular hypertrophy \| 1 HP:0005230 \| Biliary tract obstruction \| 1 HP:0006554 \| Acute hepatic failure \| 1 HP:0012211 \| Renal functional abnormality \| 1 HP:0012115 \| Liver inflammation \| 1 HP:0004870 \| hemolytic anemia, chronic \| 1 HP:0012311 \| High blood monocyte number \| 1 HP:0000124 \| Renal tubular defect \| 1 HP:0000123 \| Nephritis \| 1 HP:0001942 \| Metabolic acidosis \| 1 HP:0001655 \| Patent foramen ovale \| 1 HP:0000968 \| Ectodermal dysplasia \| 1 HP:0100584 \| Endocarditis \| 1 HP:0001693 \| Cardiac shunt \| 1 HP:0003418 \| Back pain \| 1 HP:0005584 \| Renal cell carcinoma \| 1 HP:0002669 \| Osteosarcoma \| 1 HP:0000135 \| Hypogonadism \| 1 HP:0012378 \| Fatigue \| 1 HP:0002140 \| Ischemic stroke \| 1 HP:0000989 \| pruritis \| 1 HP:0001298 \| Encephalopathy \| 1 HP:0002719 \| infections, recurrent \| 1 HP:0001406 \| Intrahepatic cholestasis \| 1 HP:0002133 \| Status epilepticus \| 1 HP:0000083 \| Renal insufficiency \| 1 HP:0004387 \| Enterocolitis \| 1 HP:0012587 \| Gross hematuria \| 1 HP:0003613 \| Antiphospholipid antibodies \| 1 HP:0000689 \| Misalignment of upper and lower dental arches \| 1 HP:0002664 \| Neoplasia \| 1 HP:0002138 \| Subarachnoid hemorrhage \| 1 HP:0001433 \| Enlarged liver and spleen \| 1 HP:0012541 \| Cephalohaematoma \| 1 HP:0012214 \| Increased glomerular filtration rate \| 1 HP:0001712 \| Left ventricular hypertrophy \| 1 HP:0000819 \| Diabetes mellitus \| 1 HP:0004395 \| Malnutrition \| 1 HP:0000047 \| Hypospadias \| 1 HP:0006775 \| Multiple myeloma \| 1

Disease ID	17
Disease	sickle cell anemia
Manually Symptom	UMLS \| Name(Total Manually Symptoms:156) C2712335 \| dehydration C2711515 \| stuttering priapism C2711515 \| recurrent priapism C2707258 \| infections C2678504 \| osteoporosis C2613439 \| extramedullary hematopoiesis C2598155 \| pain C2364133 \| infection C2364072 \| depression C2363906 \| splenic calcification C2186532 \| liver disease C1963220 \| pulmonary hypertension C1963198 \| pancreatitis C1963154 \| renal failure C1963138 \| hypertension C1962972 \| proteinuria C1863767 \| m syndrome C1739376 \| orbital apex syndrome C1546533 \| abscess C1533618 \| fat embolism C1521999 \| acute myocardial infarction C1417247 \| glomerulosclerosis C1393529 \| vascular complications C1384665 \| hemochromatosis C1290708 \| mandibular osteomyelitis C1253937 \| pericardial effusion C1148477 \| sudden deafness C1096458 \| vascular occlusion C1090821 \| sepsis C0948600 \| organ failure C0948355 \| myocardial bridge C0948201 \| alloimmunization C0947622 \| gallstones C0936215 \| vitamin b6 deficiency C0917996 \| cerebral aneurysms C0878544 \| cardiomyopathy C0877221 \| erythroblastopenia C0857891 \| pasteurella multocida sepsis C0853882 \| reticuloendothelial dysfunction C0836924 \| thrombocytosis C0796095 \| c syndrome C0752303 \| urological manifestations C0751955 \| brain infarction C0742343 \| acute chest syndrome C0742342 \| chest syndrome C0741949 \| cardiovascular pathology C0730345 \| microalbuminuria C0702166 \| acnes C0684256 \| bacterial septicemia C0522051 \| acute chest pain C0494491 \| mononeuropathy C0424810 \| periorbital swelling C0424755 \| fever C0423042 \| divergence paralysis C0409974 \| lupus erythematosus C0398623 \| hypercoagulable state C0393972 \| spinal cord infarction C0341439 \| chronic liver disease C0272412 \| splenic abscess C0270327 \| enuresis C0268749 \| immunotactoid glomerulopathy C0242666 \| protein s deficiency C0241885 \| exercise intolerance C0240066 \| iron deficiency C0237987 \| g6pd deficiency C0235950 \| zinc deficiency C0235574 \| intravascular hemolysis C0221123 \| hemolytic transfusion reaction C0220847 \| hepatitis c C0206255 \| malaria C0152964 \| streptococcal bacteremia C0152491 \| salmonella osteomyelitis C0151744 \| myocardial ischemia C0151721 \| testicular failure C0085605 \| hepatic failure C0085436 \| cryptococcal meningitis C0085273 \| parvovirus b19 infection C0085082 \| fungemia C0042373 \| vascular disease C0042133 \| leiomyoma C0040038 \| thromboembolism C0038525 \| subarachnoid hemorrhage C0038454 \| stroke C0038454 \| cerebrovascular accidents C0038454 \| cerebral infarction C0037299 \| skin ulceration C0037036 \| ptyalism C0036690 \| septicemia C0036117 \| salmonella infections C0034074 \| pulmonary infarction C0033117 \| priapism C0032285 \| pneumoniae C0032269 \| pneumococcal infections C0032269 \| pneumococcal infection C0030312 \| pancytopenia C0029443 \| osteomyelitis C0029166 \| oral manifestations C0027765 \| neurological disease C0027697 \| nephritis C0027051 \| myocardial infarction C0026764 \| multiple myeloma C0026654 \| moyamoya syndrome C0026267 \| mitral valve prolapse C0025289 \| meningitis C0024591 \| malignant hyperthermia C0023895 \| liver diseases C0023473 \| chronic myelogenous leukemia C0023473 \| chronic granulocytic leukemia C0023434 \| chronic lymphocytic leukemia C0023241 \| legionnaires' disease C0023223 \| leg ulcers C0022667 \| kidney papillary necrosis C0022661 \| chronic renal failure C0022660 \| acute renal failure C0022658 \| renal disease C0022658 \| nephropathy C0021308 \| infarction C0020676 \| hypothyroidism C0020619 \| hypogonadism C0020532 \| hypersplenism C0020428 \| hyperaldosteronism C0019829 \| hodgkin's disease C0019623 \| malignant histiocytosis C0019154 \| hepatic vein thrombosis C0019114 \| hemosiderosis C0019080 \| hemorrhage C0019045 \| globin abnormality C0018802 \| congestive heart failure C0018799 \| heart disease C0018799 \| cardiopathy C0018784 \| sensorineural hearing loss C0018099 \| gout C0016977 \| biliary disease C0015814 \| femur head necrosis C0014544 \| epilepsy C0013295 \| duodenal ulcer C0011334 \| dental caries C0009398 \| color vision defects C0008707 \| chronic osteomyelitis C0008370 \| cholestasis C0008350 \| cholelithiasis C0007785 \| cerebral infarcts C0007785 \| cerebral infarctions C0007785 \| cerebral infarct C0007766 \| intracranial aneurysms C0007766 \| intracranial aneurysm C0005940 \| bone disease C0005424 \| biliary tract disease C0004623 \| bacterial infections C0004623 \| bacterial infection C0004610 \| bacteremia C0004576 \| babesiosis C0003969 \| vitamin c deficiency C0003864 \| arthritis C0002622 \| amnesia C0002312 \| alpha-thalassemia
Text Mined Symptom	UMLS \| Name \| Sentences' Count(Total Symptoms:96) C0030193 \| pain \| 39 C0038454 \| stroke \| 31 C0020538 \| hypertension \| 24 C0742343 \| acute chest syndrome \| 24 C0020542 \| pulmonary hypertension \| 23 C0948201 \| alloimmunization \| 21 C0033117 \| priapism \| 15 C0009450 \| infection \| 15 C0021308 \| infarction \| 11 C0029443 \| osteomyelitis \| 11 C0282193 \| iron overload \| 10 C0021311 \| infections \| 9 C1393529 \| vascular complications \| 7 C0002871 \| anemia \| 6 C0730345 \| microalbuminuria \| 5 C0038454 \| strokes \| 5 C0042373 \| vascular disease \| 4 C0398623 \| hypercoagulable state \| 4 C0023223 \| leg ulcers \| 4 C0742342 \| chest syndrome \| 3 C0033687 \| proteinuria \| 3 C0004610 \| bacteremia \| 3 C0008350 \| gallstones \| 3 C0004623 \| bacterial infection \| 3 C0278140 \| severe pain \| 3 C0221123 \| hemolytic transfusion reaction \| 3 C0011175 \| dehydration \| 3 C0023223 \| leg ulcer \| 3 C0040053 \| thrombosis \| 3 C0003864 \| arthritis \| 3 C0150055 \| chronic pain \| 3 C0000737 \| abdominal pain \| 2 C0002871 \| anaemia \| 2 C1619734 \| pulmonary arterial hypertension \| 2 C0024530 \| malaria \| 2 C1384666 \| hearing loss \| 2 C0008350 \| cholelithiasis \| 2 C0398623 \| hypercoagulability \| 2 C0011570 \| depression \| 2 C0014394 \| enuresis \| 2 C0018784 \| sensorineural hearing loss \| 2 C0032269 \| pneumococcal infection \| 2 C0022661 \| end-stage renal disease \| 2 C1096458 \| vascular occlusion \| 2 C0270327 \| nocturnal enuresis \| 2 C0026654 \| moyamoya syndrome \| 2 C0037998 \| splenic infarct \| 2 C0184567 \| acute pain \| 2 C0242350 \| erectile dysfunction \| 2 C1260402 \| splenic sequestration \| 2 C0007785 \| cerebral infarct \| 2 C0008372 \| intrahepatic cholestasis \| 1 C0740985 \| acute anaemia \| 1 C0036690 \| sepsis \| 1 C1536066 \| splenic sequestration crisis \| 1 C0002878 \| hemolytic anemia \| 1 C0085082 \| fungemia \| 1 C0022408 \| arthropathy \| 1 C0018799 \| heart disease \| 1 C0016053 \| fibromyalgia \| 1 C0040038 \| thromboembolism \| 1 C0748625 \| sequestration crisis \| 1 C0026654 \| moyamoya \| 1 C0022116 \| ischemia \| 1 C0085605 \| hepatic failure \| 1 C0856169 \| endothelial dysfunction \| 1 C0020581 \| hyphema \| 1 C0027726 \| nephrotic syndrome \| 1 C0524910 \| chronic hepatitis c \| 1 C0392041 \| testicular infarction \| 1 C0020532 \| hypersplenism \| 1 C0702166 \| acnes \| 1 C0036117 \| salmonella infection \| 1 C0152491 \| salmonella osteomyelitis \| 1 C0019080 \| hemorrhage \| 1 C0013922 \| embolism \| 1 C0003874 \| septic arthritis \| 1 C0014118 \| endocarditis \| 1 C0752303 \| urological manifestations \| 1 C0014544 \| epilepsy \| 1 C0038525 \| subarachnoid hemorrhage \| 1 C0263560 \| chronic leg ulcer \| 1 C0730362 \| maculopathy \| 1 C0033774 \| pruritus \| 1 C0024141 \| systemic lupus erythematosus \| 1 C0022346 \| jaundice \| 1 C0017086 \| gangrene \| 1 C0032285 \| pneumoniae \| 1 C0442874 \| neuropathy \| 1 C0026764 \| multiple myeloma \| 1 C0796095 \| c syndrome \| 1 C0007785 \| cerebral infarcts \| 1 C0019196 \| hepatitis c \| 1 C0004623 \| bacterial infections \| 1 C0009814 \| stenosis \| 1 C0007785 \| cerebral infarction \| 1

Manually Genotype(Total Text Mining Genotypes:0)
(Waiting for update.)

All Snps(Total Genotypes:31)
snpId	pubmedId	geneId	geneSymbol	diseaseId	sourceId	sentence	score	Year	geneSymbol_dbSNP	CHROMOSOME	POS	REF	ALT
rs104894696	25117103	3077	HFE	umls:C0002895	BeFree	We assessed the frequency of the G71D mutation of the HAMP gene and the H63D mutation of the HFE gene and the correlation between these mutations as well as the correlation between them and the iron overload in sickle cell disease (SCD) patients.	0.002909916	2015	HAMP	19	35284999	G	A
rs104894696	25117103	57817	HAMP	umls:C0002895	BeFree	We assessed the frequency of the G71D mutation of the HAMP gene and the H63D mutation of the HFE gene and the correlation between these mutations as well as the correlation between them and the iron overload in sickle cell disease (SCD) patients.	0.000814326	2015	HAMP	19	35284999	G	A
rs11968814	21326311	135152	B3GAT2	umls:C0002895	GAD	[Genome-wide association study identifies genetic variants influencing F-cell levels in sickle-cell patients.]	0.002367032	2011	LOC101928394	6	71067268	G	A
rs12073837	21326311	64757	1-Mar	umls:C0002895	GAD	[Genome-wide association study identifies genetic variants influencing F-cell levels in sickle-cell patients.]	0.002367032	2011	HLX-AS1	1	220836863	C	T
rs12559632	21326311	5251	PHEX	umls:C0002895	GAD	[Genome-wide association study identifies genetic variants influencing F-cell levels in sickle-cell patients.]	0.002367032	2011	PHEX	X	22142875	G	A
rs1318772	21326311	4163	MCC	umls:C0002895	GAD	[Genome-wide association study identifies genetic variants influencing F-cell levels in sickle-cell patients.]	0.002367032	2011	MCC	5	113387870	A	G
rs17135859	21326311	64848	YTHDC2	umls:C0002895	GAD	[Genome-wide association study identifies genetic variants influencing F-cell levels in sickle-cell patients.]	0.002367032	2011	NA	5	113660957	T	C
rs1799945	25117103	57817	HAMP	umls:C0002895	BeFree	We assessed the frequency of the G71D mutation of the HAMP gene and the H63D mutation of the HFE gene and the correlation between these mutations as well as the correlation between them and the iron overload in sickle cell disease (SCD) patients.	0.000814326	2015	HFE	6	26090951	C	G
rs1799945	25117103	3077	HFE	umls:C0002895	BeFree	We assessed the frequency of the G71D mutation of the HAMP gene and the H63D mutation of the HFE gene and the correlation between these mutations as well as the correlation between them and the iron overload in sickle cell disease (SCD) patients.	0.002909916	2015	HFE	6	26090951	C	G
rs1845344	21326311	8654	PDE5A	umls:C0002895	GAD	[Genome-wide association study identifies genetic variants influencing F-cell levels in sickle-cell patients.]	0.002909916	2011	NA	4	120041230	G	T
rs2107538	23900864	6352	CCL5	umls:C0002895	BeFree	Frequency of three polymorphisms of the CCL5 gene (rs2107538, rs2280788 and rs2280789) and their implications for the phenotypic expression of sickle cell anemia in Tunisia.	0.002638474	2013	CCL5;LOC105371744	17	35880776	C	T
rs2280788	23900864	6352	CCL5	umls:C0002895	BeFree	Frequency of three polymorphisms of the CCL5 gene (rs2107538, rs2280788 and rs2280789) and their implications for the phenotypic expression of sickle cell anemia in Tunisia.	0.002638474	2013	CCL5;LOC105371744	17	35880401	G	C
rs2280789	23900864	6352	CCL5	umls:C0002895	BeFree	Frequency of three polymorphisms of the CCL5 gene (rs2107538, rs2280788 and rs2280789) and their implications for the phenotypic expression of sickle cell anemia in Tunisia.	0.002638474	2013	CCL5;LOC105371744	17	35879999	A	G
rs2577720	21326311	338	APOB	umls:C0002895	GAD	[Genome-wide association study identifies genetic variants influencing F-cell levels in sickle-cell patients.]	0.005005506	2011	NA	2	23325743	A	C
rs334	NA	3043	HBB	umls:C0002895	CLINVAR	NA	0.57785996	NA	HBB	11	5227002	T	G,C,A
rs334	13464827	3043	HBB	umls:C0002895	UNIPROT	Gene mutations in human haemoglobin: the chemical difference between normal and sickle cell haemoglobin.	0.57785996	1957	HBB	11	5227002	T	G,C,A
rs33930165	NA	3043	HBB	umls:C0002895	CLINVAR	NA	0.57785996	NA	HBB	11	5227003	C	T,G
rs33946267	NA	3043	HBB	umls:C0002895	CLINVAR	NA	0.57785996	NA	HBB	11	5225678	C	T,G,A
rs33950507	NA	3043	HBB	umls:C0002895	CLINVAR	NA	0.57785996	NA	HBB	11	5226943	C	T,G,A
rs3800569	21326311	50617	ATP6V0A4	umls:C0002895	GAD	[Genome-wide association study identifies genetic variants influencing F-cell levels in sickle-cell patients.]	0.002367032	2011	ATP6V0A4	7	138726680	C	T
rs397507444	16987799	4524	MTHFR	umls:C0002895	BeFree	Association of the methylenetetrahydrofolate reductase A1298C but not the C677T single nucleotide polymorphism with sickle cell disease in Bahrain.	0.025103474	2006	MTHFR	1	11794407	T	G
rs41322052	14687036	4846	NOS3	umls:C0002895	BeFree	Association of T-786C eNOS gene polymorphism with increased susceptibility to acute chest syndrome in females with sickle cell disease.	0.009272631	2004	NOS3	7	150993018	C	T
rs4680	25102390	1814	DRD3	umls:C0002895	BeFree	Dopamine D3 receptor Ser9Gly and catechol-o-methyltransferase Val158Met polymorphisms and acute pain in sickle cell disease.	0.000271442	2015	COMT;MIR4761	22	19963748	G	A
rs4680	25102390	1312	COMT	umls:C0002895	BeFree	Dopamine D3 receptor Ser9Gly and catechol-o-methyltransferase Val158Met polymorphisms and acute pain in sickle cell disease.	0.000271442	2015	COMT;MIR4761	22	19963748	G	A
rs6280	25102390	1312	COMT	umls:C0002895	BeFree	Dopamine D3 receptor Ser9Gly and catechol-o-methyltransferase Val158Met polymorphisms and acute pain in sickle cell disease.	0.000271442	2015	DRD3	3	114171968	C	T
rs6280	25102390	1814	DRD3	umls:C0002895	BeFree	Dopamine D3 receptor Ser9Gly and catechol-o-methyltransferase Val158Met polymorphisms and acute pain in sickle cell disease.	0.000271442	2015	DRD3	3	114171968	C	T
rs660	19201475	6737	TRIM21	umls:C0002895	BeFree	rs660 polymorphism in Ro52 (SSA1; TRIM21) is a marker for age-dependent tolerance induction and efficiency of alloimmunization in sickle cell disease.	0.002638474	2009	NA	NA	NA	NA	NA
rs7203560	23406172	8131	NPRL3	umls:C0002895	GWASCAT	Genetic determinants of haemolysis in sickle cell anaemia.	0.12	2013	NPRL3	16	134391	T	G
rs766432	25042611	53335	BCL11A	umls:C0002895	GWASCAT	The genetics of hemoglobin A2 regulation in sickle cell anemia.	0.131725539	2014	BCL11A	2	60492835	C	A
rs766432	23406172	53335	BCL11A	umls:C0002895	GWASCAT	Genetic determinants of haemolysis in sickle cell anaemia.	0.131725539	2013	BCL11A	2	60492835	C	A
rs887829	22558097	54658	UGT1A1	umls:C0002895	GAD	[These results confirm that the UGT1A region is the major regulator of bilirubin metabolism in African Americans with sickle cell anemia, similar to what is observed in other ethnicities.]	0.028899779	2012	UGT1A10;UGT1A8;UGT1A7;UGT1A6;UGT1A5;UGT1A9;UGT1A4;UGT1A1;UGT1A3	2	233759924	C	T

GWASdb Annotation(Total Genotypes:1)
Chr	Pos	SNP_Id	RefGene	EnsemblGene	ENCODE_Factor	ENCODE_TFBS	Chromosome_interaction	GTEx_eQTL	SNP_TFBS_affinity_GWAS3D	SNP_miRNA_target_affinity_PolymiRTS	SNP_splicing_effect_Skippy	SNP_splicing_effect_MutPred_Splice	SNP_ns_protein_effect_dbNSFP	SNP_syn_effect_Silva	SNP_phosphorylation_effect_PhosSNP	PhastCons_score	PhyloP_score	GERP++_RS	Segway_state	Ancestral_allele	ESP_AF	ESP_AFR	ESP_AFR	ESP_EUR	TG_ASN	TG_AMR	TG_AFR	TG_EUR	Type	Consequence	bStatistic	EncH3K27Ac	EncH3K4Me1	EncH3K4Me3	EncNucleo	OMIM	Clinvar
10	102121579	rs3978768	NM_005063,SCD	ENST00000370355,ENSG00000099194	TFP.SP1	NA	chr10,102120001,102130000,chr10,102160001,102170000,7,Hi-C	NA	Ecm22-primary,1.3019	Fkh1-FL-primary,1.3328	Gsm1-FL-primary,2.0868	Gsm1-FL-primary,1.3947	Hoxc12_3480,1.6159	hsa-miR-514a-5p,-0.140000	hsa-miR-518c-5p,-0.140000	NA	NA	NA	NA	NA	0.004	0.737	2.28	GE1	A	NA	NA	NA	NA	NA	NA	NA	NA	NonCodingTranscript	NONCODING_CHANGE	645	3.32

GWASdb Snp Trait(Total Genotypes:260)
CHR	POS	SNPID	REF	ALT	ORI_SNPID	PMID	P_VALUE	P_VALUE_TEXT	OR/BETA	CI95_TEXT	GWAS_INITIAL_SAMPLE_SIZE	SUB_POPULATION	SUPER_POPULATION	GWAS_TRAIT	HPO_ID	HPO_TERM	DO_ID	DO_TERM	MESH_ID	MESH_TERM	EFO_ID	EFO_TERM	DOLITE_TERM	RISK_ALLELE	PUBLICATION_TYPE	AA	GENE_SYMBOL	TYPE	REFGENE
1	20209469	rs12124726	A	C	rs12124726	20029952	2.55E-08	Sickle cell anemia severity	NA	NA	177 African American severe patients; 1088 African American mild patients	African American(1265)	ALL(1265)	AFR(1265)	ALL(1265)	Sickle cell anemia (severity)	HPOID:0008346	Increased red cell sickling tendency	DOID:10923	sickle cell anemia	NA	NA	NA	NA	Sickle cell disease	NA	Research Support, N.I.H., Extramural	A	OTUD3
1	44999614	rs746733	G	A	rs746733	21326311	3.55E-05	NA	NA	NA	440 African ancestry individuals	African(440)	ALL(440)	AFR(440)	ALL(440)	F-cell distribution	HPOID:0008346	Increased red cell sickling tendency	DOID:10923	sickle cell anemia	D005319	Fetal Hemoglobin	EFOID:0004576	sickle cell anemia	Sickle cell disease	NA	Research Support, N.I.H., Extramural	C	RNF220
1	56968477	rs4912314	C	T	rs4912314	20029952	2.02E-05	Sickle cell anemia severity	NA	NA	177 African American severe patients; 1088 African American mild patients	African American(1265)	ALL(1265)	AFR(1265)	ALL(1265)	Sickle cell anemia (severity)	HPOID:0008346	Increased red cell sickling tendency	DOID:10923	sickle cell anemia	NA	NA	NA	NA	Sickle cell disease	NA	Research Support, N.I.H., Extramural	T	PPAP2B
1	76680525	rs517036	T	C	rs517036	21326311	3.25E-06	NA	NA	NA	440 African ancestry individuals	African(440)	ALL(440)	AFR(440)	ALL(440)	F-cell distribution	HPOID:0008346	Increased red cell sickling tendency	DOID:10923	sickle cell anemia	D005319	Fetal Hemoglobin	EFOID:0004576	sickle cell anemia	Sickle cell disease	NA	Research Support, N.I.H., Extramural	A	ST6GALNAC3
1	76687275	rs547342	A	G	rs547342	21326311	1.09E-05	NA	NA	NA	440 African ancestry individuals	African(440)	ALL(440)	AFR(440)	ALL(440)	F-cell distribution	HPOID:0008346	Increased red cell sickling tendency	DOID:10923	sickle cell anemia	D005319	Fetal Hemoglobin	EFOID:0004576	sickle cell anemia	Sickle cell disease	NA	Research Support, N.I.H., Extramural	T	ST6GALNAC3
1	115355281	rs2798657	C	T	rs2798657	21326311	2.96E-05	NA	NA	NA	440 African ancestry individuals	African(440)	ALL(440)	AFR(440)	ALL(440)	F-cell distribution	HPOID:0008346	Increased red cell sickling tendency	DOID:10923	sickle cell anemia	D005319	Fetal Hemoglobin	EFOID:0004576	sickle cell anemia	Sickle cell disease	NA	Research Support, N.I.H., Extramural	T	NA
1	152514332	rs549044	C	T	rs549044	21326311	3.11E-05	NA	NA	NA	440 African ancestry individuals	African(440)	ALL(440)	AFR(440)	ALL(440)	F-cell distribution	HPOID:0008346	Increased red cell sickling tendency	DOID:10923	sickle cell anemia	D005319	Fetal Hemoglobin	EFOID:0004576	sickle cell anemia	Sickle cell disease	NA	Research Support, N.I.H., Extramural	G	NA
1	191220906	rs1246813	T	C	rs1246813	21326311	3.29E-05	NA	NA	NA	440 African ancestry individuals	African(440)	ALL(440)	AFR(440)	ALL(440)	F-cell distribution	HPOID:0008346	Increased red cell sickling tendency	DOID:10923	sickle cell anemia	D005319	Fetal Hemoglobin	EFOID:0004576	sickle cell anemia	Sickle cell disease	NA	Research Support, N.I.H., Extramural	G	NA
1	191397516	rs6700152	A	G	rs6700152	21326311	1.55E-05	NA	NA	NA	440 African ancestry individuals	African(440)	ALL(440)	AFR(440)	ALL(440)	F-cell distribution	HPOID:0008346	Increased red cell sickling tendency	DOID:10923	sickle cell anemia	D005319	Fetal Hemoglobin	EFOID:0004576	sickle cell anemia	Sickle cell disease	NA	Research Support, N.I.H., Extramural	A	NA
1	205423893	rs10900493	G	A	rs10900493	21326311	2.49E-05	NA	NA	NA	440 African ancestry individuals	African(440)	ALL(440)	AFR(440)	ALL(440)	F-cell distribution	HPOID:0008346	Increased red cell sickling tendency	DOID:10923	sickle cell anemia	D005319	Fetal Hemoglobin	EFOID:0004576	sickle cell anemia	Sickle cell disease	NA	Research Support, N.I.H., Extramural	G	NA
1	220988346	rs4143772	G	A	rs4143772	21326311	1.12E-05	NA	NA	NA	440 African ancestry individuals	African(440)	ALL(440)	AFR(440)	ALL(440)	F-cell distribution	HPOID:0008346	Increased red cell sickling tendency	DOID:10923	sickle cell anemia	D005319	Fetal Hemoglobin	EFOID:0004576	sickle cell anemia	Sickle cell disease	NA	Research Support, N.I.H., Extramural	G	NA
1	221001787	rs2279638	G	A	rs2279638	21326311	7.49E-06	NA	NA	NA	440 African ancestry individuals	African(440)	ALL(440)	AFR(440)	ALL(440)	F-cell distribution	HPOID:0008346	Increased red cell sickling tendency	DOID:10923	sickle cell anemia	D005319	Fetal Hemoglobin	EFOID:0004576	sickle cell anemia	Sickle cell disease	NA	Research Support, N.I.H., Extramural	G	NA
1	221010205	rs12073837	C	T	rs12073837	21326311	2.00E-06	NA	1.39	[0.82-1.96] unit increase	440 African ancestry individuals	African(440)	ALL(440)	AFR(440)	ALL(440)	F-cell distribution	HPOID:0008346	Increased red cell sickling tendency	DOID:10923	sickle cell anemia	D005319	Fetal Hemoglobin	EFOID:0004576	sickle cell anemia	Sickle cell disease	rs12073837-T	Research Support, N.I.H., Extramural	C	NA
1	221579628	rs3131533	A	G	rs3131533	21326311	2.14E-05	NA	NA	NA	440 African ancestry individuals	African(440)	ALL(440)	AFR(440)	ALL(440)	F-cell distribution	HPOID:0008346	Increased red cell sickling tendency	DOID:10923	sickle cell anemia	D005319	Fetal Hemoglobin	EFOID:0004576	sickle cell anemia	Sickle cell disease	NA	Research Support, N.I.H., Extramural	G	NA
1	226708481	rs584297	T	C	rs584297	21326311	3.26E-05	NA	NA	NA	440 African ancestry individuals	African(440)	ALL(440)	AFR(440)	ALL(440)	F-cell distribution	HPOID:0008346	Increased red cell sickling tendency	DOID:10923	sickle cell anemia	D005319	Fetal Hemoglobin	EFOID:0004576	sickle cell anemia	Sickle cell disease	NA	Research Support, N.I.H., Extramural	C	NA
1	238274904	rs12078672	T	C	rs12078672	20029952	2.51E-06	Sickle cell anemia severity	NA	NA	177 African American severe patients; 1088 African American mild patients	African American(1265)	ALL(1265)	AFR(1265)	ALL(1265)	Sickle cell anemia (severity)	HPOID:0008346	Increased red cell sickling tendency	DOID:10923	sickle cell anemia	NA	NA	NA	NA	Sickle cell disease	NA	Research Support, N.I.H., Extramural	T	NA
2	726564	rs3924384	T	C	rs3924384	20029952	1.50E-05	Sickle cell anemia severity	NA	NA	177 African American severe patients; 1088 African American mild patients	African American(1265)	ALL(1265)	AFR(1265)	ALL(1265)	Sickle cell anemia (severity)	HPOID:0008346	Increased red cell sickling tendency	DOID:10923	sickle cell anemia	NA	NA	NA	NA	Sickle cell disease	NA	Research Support, N.I.H., Extramural	A	NA
2	729948	rs7580986	G	T	rs7580986	20029952	2.35E-06	Sickle cell anemia severity	NA	NA	177 African American severe patients; 1088 African American mild patients	African American(1265)	ALL(1265)	AFR(1265)	ALL(1265)	Sickle cell anemia (severity)	HPOID:0008346	Increased red cell sickling tendency	DOID:10923	sickle cell anemia	NA	NA	NA	NA	Sickle cell disease	NA	Research Support, N.I.H., Extramural	T	NA
2	23548614	rs2577720	A	C	rs2577720	21326311	8.00E-06	NA	0.82	[0.47-1.17] unit decrease	440 African ancestry individuals	African(440)	ALL(440)	AFR(440)	ALL(440)	F-cell distribution	HPOID:0008346	Increased red cell sickling tendency	DOID:10923	sickle cell anemia	D005319	Fetal Hemoglobin	EFOID:0004576	sickle cell anemia	Sickle cell disease	rs2577720-C	Research Support, N.I.H., Extramural	T	NA
2	27405497	rs6709602	C	T	rs6709602	21326311	3.23E-05	NA	NA	NA	440 African ancestry individuals	African(440)	ALL(440)	AFR(440)	ALL(440)	F-cell distribution	HPOID:0008346	Increased red cell sickling tendency	DOID:10923	sickle cell anemia	D005319	Fetal Hemoglobin	EFOID:0004576	sickle cell anemia	Sickle cell disease	NA	Research Support, N.I.H., Extramural	C	NA
2	60603602	rs243033	G	C	rs243033	17767159	9.40E-05	NA	NA	NA	179 adults in upper and lower 5%	NOPOP(179)	ALL(179)	NOPOP(179)	ALL(179)	F-cell distribution	HPOID:0008346	Increased red cell sickling tendency	DOID:10923	sickle cell anemia	D005319	Fetal Hemoglobin	EFOID:0004576	sickle cell anemia	Sickle cell disease	NA	Research Support, Non-U.S. Gov't	C	NA
2	60603950	rs243032	G	A	rs243032	17767159	4.20E-07	NA	NA	NA	179 adults in upper and lower 5%	NOPOP(179)	ALL(179)	NOPOP(179)	ALL(179)	F-cell distribution	HPOID:0008346	Increased red cell sickling tendency	DOID:10923	sickle cell anemia	D005319	Fetal Hemoglobin	EFOID:0004576	sickle cell anemia	Sickle cell disease	NA	Research Support, Non-U.S. Gov't	C	NA
2	60605919	rs173373	C	T	rs173373	17767159	7.00E-09	NA	NA	NA	179 adults in upper and lower 5%	NOPOP(179)	ALL(179)	NOPOP(179)	ALL(179)	F-cell distribution	HPOID:0008346	Increased red cell sickling tendency	DOID:10923	sickle cell anemia	D005319	Fetal Hemoglobin	EFOID:0004576	sickle cell anemia	Sickle cell disease	NA	Research Support, Non-U.S. Gov't	G	NA
2	60606571	rs243030	C	T	rs243030	17767159	1.70E-08	NA	NA	NA	179 adults in upper and lower 5%	NOPOP(179)	ALL(179)	NOPOP(179)	ALL(179)	F-cell distribution	HPOID:0008346	Increased red cell sickling tendency	DOID:10923	sickle cell anemia	D005319	Fetal Hemoglobin	EFOID:0004576	sickle cell anemia	Sickle cell disease	NA	Research Support, Non-U.S. Gov't	A	NA
2	60606654	rs243029	C	T	rs243029	17767159	4.20E-08	NA	NA	NA	179 adults in upper and lower 5%	NOPOP(179)	ALL(179)	NOPOP(179)	ALL(179)	F-cell distribution	HPOID:0008346	Increased red cell sickling tendency	DOID:10923	sickle cell anemia	D005319	Fetal Hemoglobin	EFOID:0004576	sickle cell anemia	Sickle cell disease	NA	Research Support, Non-U.S. Gov't	A	NA
2	60607007	rs243027	T	G	rs243027	17767159	2.20E-10	NA	NA	NA	179 adults in upper and lower 5%	NOPOP(179)	ALL(179)	NOPOP(179)	ALL(179)	F-cell distribution	HPOID:0008346	Increased red cell sickling tendency	DOID:10923	sickle cell anemia	D005319	Fetal Hemoglobin	EFOID:0004576	sickle cell anemia	Sickle cell disease	NA	Research Support, Non-U.S. Gov't	C	NA
2	60607007	rs243027	T	G	rs243027	21326311	2.20E-10	NA	NA	NA	440 African ancestry individuals	African(440)	ALL(440)	AFR(440)	ALL(440)	F-cell distribution	HPOID:0008346	Increased red cell sickling tendency	DOID:10923	sickle cell anemia	D005319	Fetal Hemoglobin	EFOID:0004576	sickle cell anemia	Sickle cell disease	NA	Research Support, N.I.H., Extramural	C	NA
2	60607728	rs13027161	T	C	rs13027161	17767159	3.50E-08	NA	NA	NA	179 adults in upper and lower 5%	NOPOP(179)	ALL(179)	NOPOP(179)	ALL(179)	F-cell distribution	HPOID:0008346	Increased red cell sickling tendency	DOID:10923	sickle cell anemia	D005319	Fetal Hemoglobin	EFOID:0004576	sickle cell anemia	Sickle cell disease	NA	Research Support, Non-U.S. Gov't	T	NA
2	60608383	rs2668729	G	A	rs2668729	17767159	3.20E-08	NA	NA	NA	179 adults in upper and lower 5%	NOPOP(179)	ALL(179)	NOPOP(179)	ALL(179)	F-cell distribution	HPOID:0008346	Increased red cell sickling tendency	DOID:10923	sickle cell anemia	D005319	Fetal Hemoglobin	EFOID:0004576	sickle cell anemia	Sickle cell disease	NA	Research Support, Non-U.S. Gov't	G	NA
2	60608759	rs2540917	T	C	rs2540917	17767159	5.60E-09	NA	NA	NA	179 adults in upper and lower 5%	NOPOP(179)	ALL(179)	NOPOP(179)	ALL(179)	F-cell distribution	HPOID:0008346	Increased red cell sickling tendency	DOID:10923	sickle cell anemia	D005319	Fetal Hemoglobin	EFOID:0004576	sickle cell anemia	Sickle cell disease	NA	Research Support, Non-U.S. Gov't	A	NA
2	60608930	rs2540916	T	C	rs2540916	17767159	1.60E-07	NA	NA	NA	179 adults in upper and lower 5%	NOPOP(179)	ALL(179)	NOPOP(179)	ALL(179)	F-cell distribution	HPOID:0008346	Increased red cell sickling tendency	DOID:10923	sickle cell anemia	D005319	Fetal Hemoglobin	EFOID:0004576	sickle cell anemia	Sickle cell disease	NA	Research Support, Non-U.S. Gov't	A	NA
2	60609474	rs9967849	C	T	rs9967849	17767159	7.60E-09	NA	NA	NA	179 adults in upper and lower 5%	NOPOP(179)	ALL(179)	NOPOP(179)	ALL(179)	F-cell distribution	HPOID:0008346	Increased red cell sickling tendency	DOID:10923	sickle cell anemia	D005319	Fetal Hemoglobin	EFOID:0004576	sickle cell anemia	Sickle cell disease	NA	Research Support, Non-U.S. Gov't	C	NA
2	60609896	rs1553934	G	C	rs1553934	17767159	1.80E-08	NA	NA	NA	179 adults in upper and lower 5%	NOPOP(179)	ALL(179)	NOPOP(179)	ALL(179)	F-cell distribution	HPOID:0008346	Increased red cell sickling tendency	DOID:10923	sickle cell anemia	D005319	Fetal Hemoglobin	EFOID:0004576	sickle cell anemia	Sickle cell disease	NA	Research Support, Non-U.S. Gov't	G	NA
2	60611285	rs925483	G	A	rs925483	17767159	2.60E-09	NA	NA	NA	179 adults in upper and lower 5%	NOPOP(179)	ALL(179)	NOPOP(179)	ALL(179)	F-cell distribution	HPOID:0008346	Increased red cell sickling tendency	DOID:10923	sickle cell anemia	D005319	Fetal Hemoglobin	EFOID:0004576	sickle cell anemia	Sickle cell disease	NA	Research Support, Non-U.S. Gov't	G	NA
2	60611437	rs925484	C	G	rs925484	17767159	3.10E-09	NA	NA	NA	179 adults in upper and lower 5%	NOPOP(179)	ALL(179)	NOPOP(179)	ALL(179)	F-cell distribution	HPOID:0008346	Increased red cell sickling tendency	DOID:10923	sickle cell anemia	D005319	Fetal Hemoglobin	EFOID:0004576	sickle cell anemia	Sickle cell disease	NA	Research Support, Non-U.S. Gov't	C	NA
2	60612008	rs2137281	C	T	rs2137281	17767159	9.40E-10	NA	NA	NA	179 adults in upper and lower 5%	NOPOP(179)	ALL(179)	NOPOP(179)	ALL(179)	F-cell distribution	HPOID:0008346	Increased red cell sickling tendency	DOID:10923	sickle cell anemia	D005319	Fetal Hemoglobin	EFOID:0004576	sickle cell anemia	Sickle cell disease	NA	Research Support, Non-U.S. Gov't	C	NA
2	60612070	rs2137282	T	A	rs2137282	17767159	7.40E-05	NA	NA	NA	179 adults in upper and lower 5%	NOPOP(179)	ALL(179)	NOPOP(179)	ALL(179)	F-cell distribution	HPOID:0008346	Increased red cell sickling tendency	DOID:10923	sickle cell anemia	D005319	Fetal Hemoglobin	EFOID:0004576	sickle cell anemia	Sickle cell disease	NA	Research Support, Non-U.S. Gov't	T	NA
2	60612457	rs2137283	C	A	rs2137283	17767159	1.70E-09	NA	NA	NA	179 adults in upper and lower 5%	NOPOP(179)	ALL(179)	NOPOP(179)	ALL(179)	F-cell distribution	HPOID:0008346	Increased red cell sickling tendency	DOID:10923	sickle cell anemia	D005319	Fetal Hemoglobin	EFOID:0004576	sickle cell anemia	Sickle cell disease	NA	Research Support, Non-U.S. Gov't	A	NA
2	60613123	rs243082	C	T	rs243082	17767159	7.90E-05	NA	NA	NA	179 adults in upper and lower 5%	NOPOP(179)	ALL(179)	NOPOP(179)	ALL(179)	F-cell distribution	HPOID:0008346	Increased red cell sickling tendency	DOID:10923	sickle cell anemia	D005319	Fetal Hemoglobin	EFOID:0004576	sickle cell anemia	Sickle cell disease	NA	Research Support, Non-U.S. Gov't	G	NA
2	60613776	rs243081	G	A	rs243081	17767159	2.50E-12	NA	NA	NA	179 adults in upper and lower 5%	NOPOP(179)	ALL(179)	NOPOP(179)	ALL(179)	F-cell distribution	HPOID:0008346	Increased red cell sickling tendency	DOID:10923	sickle cell anemia	D005319	Fetal Hemoglobin	EFOID:0004576	sickle cell anemia	Sickle cell disease	NA	Research Support, Non-U.S. Gov't	C	NA
2	60614572	rs243080	G	A	rs243080	17767159	2.70E-08	NA	NA	NA	179 adults in upper and lower 5%	NOPOP(179)	ALL(179)	NOPOP(179)	ALL(179)	F-cell distribution	HPOID:0008346	Increased red cell sickling tendency	DOID:10923	sickle cell anemia	D005319	Fetal Hemoglobin	EFOID:0004576	sickle cell anemia	Sickle cell disease	NA	Research Support, Non-U.S. Gov't	C	NA
2	60615028	rs243079	A	C	rs243079	17767159	2.00E-09	NA	NA	NA	179 adults in upper and lower 5%	NOPOP(179)	ALL(179)	NOPOP(179)	ALL(179)	F-cell distribution	HPOID:0008346	Increased red cell sickling tendency	DOID:10923	sickle cell anemia	D005319	Fetal Hemoglobin	EFOID:0004576	sickle cell anemia	Sickle cell disease	NA	Research Support, Non-U.S. Gov't	G	NA
2	60615303	rs243078	A	G	rs243078	17767159	1.30E-08	NA	NA	NA	179 adults in upper and lower 5%	NOPOP(179)	ALL(179)	NOPOP(179)	ALL(179)	F-cell distribution	HPOID:0008346	Increased red cell sickling tendency	DOID:10923	sickle cell anemia	D005319	Fetal Hemoglobin	EFOID:0004576	sickle cell anemia	Sickle cell disease	NA	Research Support, Non-U.S. Gov't	T	NA
2	60616682	rs243077	A	G	rs243077	17767159	6.80E-04	NA	NA	NA	179 adults in upper and lower 5%	NOPOP(179)	ALL(179)	NOPOP(179)	ALL(179)	F-cell distribution	HPOID:0008346	Increased red cell sickling tendency	DOID:10923	sickle cell anemia	D005319	Fetal Hemoglobin	EFOID:0004576	sickle cell anemia	Sickle cell disease	NA	Research Support, Non-U.S. Gov't	C	NA
2	60617563	rs243076	G	A	rs243076	17767159	1.40E-08	NA	NA	NA	179 adults in upper and lower 5%	NOPOP(179)	ALL(179)	NOPOP(179)	ALL(179)	F-cell distribution	HPOID:0008346	Increased red cell sickling tendency	DOID:10923	sickle cell anemia	D005319	Fetal Hemoglobin	EFOID:0004576	sickle cell anemia	Sickle cell disease	NA	Research Support, Non-U.S. Gov't	C	NA
2	60617571	rs243075	T	C	rs243075	17767159	6.10E-04	NA	NA	NA	179 adults in upper and lower 5%	NOPOP(179)	ALL(179)	NOPOP(179)	ALL(179)	F-cell distribution	HPOID:0008346	Increased red cell sickling tendency	DOID:10923	sickle cell anemia	D005319	Fetal Hemoglobin	EFOID:0004576	sickle cell anemia	Sickle cell disease	NA	Research Support, Non-U.S. Gov't	G	NA
2	60618690	rs243073	T	C	rs243073	17767159	4.50E-04	NA	NA	NA	179 adults in upper and lower 5%	NOPOP(179)	ALL(179)	NOPOP(179)	ALL(179)	F-cell distribution	HPOID:0008346	Increased red cell sickling tendency	DOID:10923	sickle cell anemia	D005319	Fetal Hemoglobin	EFOID:0004576	sickle cell anemia	Sickle cell disease	NA	Research Support, Non-U.S. Gov't	G	NA
2	60619814	rs13401861	T	C	rs13401861	17767159	4.00E-04	NA	NA	NA	179 adults in upper and lower 5%	NOPOP(179)	ALL(179)	NOPOP(179)	ALL(179)	F-cell distribution	HPOID:0008346	Increased red cell sickling tendency	DOID:10923	sickle cell anemia	D005319	Fetal Hemoglobin	EFOID:0004576	sickle cell anemia	Sickle cell disease	NA	Research Support, Non-U.S. Gov't	T	NA
2	60620286	rs243070	T	A	rs243070	17767159	1.70E-05	NA	NA	NA	179 adults in upper and lower 5%	NOPOP(179)	ALL(179)	NOPOP(179)	ALL(179)	F-cell distribution	HPOID:0008346	Increased red cell sickling tendency	DOID:10923	sickle cell anemia	D005319	Fetal Hemoglobin	EFOID:0004576	sickle cell anemia	Sickle cell disease	NA	Research Support, Non-U.S. Gov't	A	NA
2	60621643	rs243067	G	T	rs243067	17767159	1.10E-08	NA	NA	NA	179 adults in upper and lower 5%	NOPOP(179)	ALL(179)	NOPOP(179)	ALL(179)	F-cell distribution	HPOID:0008346	Increased red cell sickling tendency	DOID:10923	sickle cell anemia	D005319	Fetal Hemoglobin	EFOID:0004576	sickle cell anemia	Sickle cell disease	NA	Research Support, Non-U.S. Gov't	C	NA
2	60621766	rs243066	A	G	rs243066	17767159	5.40E-10	NA	NA	NA	179 adults in upper and lower 5%	NOPOP(179)	ALL(179)	NOPOP(179)	ALL(179)	F-cell distribution	HPOID:0008346	Increased red cell sickling tendency	DOID:10923	sickle cell anemia	D005319	Fetal Hemoglobin	EFOID:0004576	sickle cell anemia	Sickle cell disease	NA	Research Support, Non-U.S. Gov't	T	NA
2	60622064	rs243065	G	C	rs243065	17767159	3.10E-09	NA	NA	NA	179 adults in upper and lower 5%	NOPOP(179)	ALL(179)	NOPOP(179)	ALL(179)	F-cell distribution	HPOID:0008346	Increased red cell sickling tendency	DOID:10923	sickle cell anemia	D005319	Fetal Hemoglobin	EFOID:0004576	sickle cell anemia	Sickle cell disease	NA	Research Support, Non-U.S. Gov't	C	NA
2	60622491	rs7589285	A	T	rs7589285	17767159	5.60E-04	NA	NA	NA	179 adults in upper and lower 5%	NOPOP(179)	ALL(179)	NOPOP(179)	ALL(179)	F-cell distribution	HPOID:0008346	Increased red cell sickling tendency	DOID:10923	sickle cell anemia	D005319	Fetal Hemoglobin	EFOID:0004576	sickle cell anemia	Sickle cell disease	NA	Research Support, Non-U.S. Gov't	A	NA
2	60622899	rs243063	A	T	rs243063	17767159	6.90E-09	NA	NA	NA	179 adults in upper and lower 5%	NOPOP(179)	ALL(179)	NOPOP(179)	ALL(179)	F-cell distribution	HPOID:0008346	Increased red cell sickling tendency	DOID:10923	sickle cell anemia	D005319	Fetal Hemoglobin	EFOID:0004576	sickle cell anemia	Sickle cell disease	NA	Research Support, Non-U.S. Gov't	T	NA
2	60623676	rs243062	G	A	rs243062	17767159	4.20E-10	NA	NA	NA	179 adults in upper and lower 5%	NOPOP(179)	ALL(179)	NOPOP(179)	ALL(179)	F-cell distribution	HPOID:0008346	Increased red cell sickling tendency	DOID:10923	sickle cell anemia	D005319	Fetal Hemoglobin	EFOID:0004576	sickle cell anemia	Sickle cell disease	NA	Research Support, Non-U.S. Gov't	T,C	NA
2	60623698	rs243061	T	C	rs243061	17767159	2.00E-09	NA	NA	NA	179 adults in upper and lower 5%	NOPOP(179)	ALL(179)	NOPOP(179)	ALL(179)	F-cell distribution	HPOID:0008346	Increased red cell sickling tendency	DOID:10923	sickle cell anemia	D005319	Fetal Hemoglobin	EFOID:0004576	sickle cell anemia	Sickle cell disease	NA	Research Support, Non-U.S. Gov't	A	NA
2	60626822	rs13011022	G	A	rs13011022	17767159	1.40E-09	NA	NA	NA	179 adults in upper and lower 5%	NOPOP(179)	ALL(179)	NOPOP(179)	ALL(179)	F-cell distribution	HPOID:0008346	Increased red cell sickling tendency	DOID:10923	sickle cell anemia	D005319	Fetal Hemoglobin	EFOID:0004576	sickle cell anemia	Sickle cell disease	NA	Research Support, Non-U.S. Gov't	A,G	NA
2	60627565	rs11125841	A	G	rs11125841	17767159	3.30E-08	NA	NA	NA	179 adults in upper and lower 5%	NOPOP(179)	ALL(179)	NOPOP(179)	ALL(179)	F-cell distribution	HPOID:0008346	Increased red cell sickling tendency	DOID:10923	sickle cell anemia	D005319	Fetal Hemoglobin	EFOID:0004576	sickle cell anemia	Sickle cell disease	NA	Research Support, Non-U.S. Gov't	G	NA
2	60629609	rs888082	G	A	rs888082	17767159	3.10E-09	NA	NA	NA	179 adults in upper and lower 5%	NOPOP(179)	ALL(179)	NOPOP(179)	ALL(179)	F-cell distribution	HPOID:0008346	Increased red cell sickling tendency	DOID:10923	sickle cell anemia	D005319	Fetal Hemoglobin	EFOID:0004576	sickle cell anemia	Sickle cell disease	NA	Research Support, Non-U.S. Gov't	T	NA
2	60631229	rs12995080	G	A	rs12995080	17767159	1.20E-05	NA	NA	NA	179 adults in upper and lower 5%	NOPOP(179)	ALL(179)	NOPOP(179)	ALL(179)	F-cell distribution	HPOID:0008346	Increased red cell sickling tendency	DOID:10923	sickle cell anemia	D005319	Fetal Hemoglobin	EFOID:0004576	sickle cell anemia	Sickle cell disease	NA	Research Support, Non-U.S. Gov't	G	NA
2	60633364	rs13009393	G	A	rs13009393	17767159	2.20E-10	NA	NA	NA	179 adults in upper and lower 5%	NOPOP(179)	ALL(179)	NOPOP(179)	ALL(179)	F-cell distribution	HPOID:0008346	Increased red cell sickling tendency	DOID:10923	sickle cell anemia	D005319	Fetal Hemoglobin	EFOID:0004576	sickle cell anemia	Sickle cell disease	NA	Research Support, Non-U.S. Gov't	G	NA
2	60636416	rs12464462	A	G	rs12464462	17767159	1.90E-09	NA	NA	NA	179 adults in upper and lower 5%	NOPOP(179)	ALL(179)	NOPOP(179)	ALL(179)	F-cell distribution	HPOID:0008346	Increased red cell sickling tendency	DOID:10923	sickle cell anemia	D005319	Fetal Hemoglobin	EFOID:0004576	sickle cell anemia	Sickle cell disease	NA	Research Support, Non-U.S. Gov't	G	NA
2	60636497	rs12472541	C	A	rs12472541	17767159	3.90E-04	NA	NA	NA	179 adults in upper and lower 5%	NOPOP(179)	ALL(179)	NOPOP(179)	ALL(179)	F-cell distribution	HPOID:0008346	Increased red cell sickling tendency	DOID:10923	sickle cell anemia	D005319	Fetal Hemoglobin	EFOID:0004576	sickle cell anemia	Sickle cell disease	NA	Research Support, Non-U.S. Gov't	C	NA
2	60637656	rs10445937	G	A	rs10445937	17767159	3.10E-09	NA	NA	NA	179 adults in upper and lower 5%	NOPOP(179)	ALL(179)	NOPOP(179)	ALL(179)	F-cell distribution	HPOID:0008346	Increased red cell sickling tendency	DOID:10923	sickle cell anemia	D005319	Fetal Hemoglobin	EFOID:0004576	sickle cell anemia	Sickle cell disease	NA	Research Support, Non-U.S. Gov't	A	NA
2	60639733	rs17330904	T	C	rs17330904	17767159	5.10E-04	NA	NA	NA	179 adults in upper and lower 5%	NOPOP(179)	ALL(179)	NOPOP(179)	ALL(179)	F-cell distribution	HPOID:0008346	Increased red cell sickling tendency	DOID:10923	sickle cell anemia	D005319	Fetal Hemoglobin	EFOID:0004576	sickle cell anemia	Sickle cell disease	NA	Research Support, Non-U.S. Gov't	T	NA
2	60639904	rs12476132	G	A	rs12476132	17767159	2.90E-09	NA	NA	NA	179 adults in upper and lower 5%	NOPOP(179)	ALL(179)	NOPOP(179)	ALL(179)	F-cell distribution	HPOID:0008346	Increased red cell sickling tendency	DOID:10923	sickle cell anemia	D005319	Fetal Hemoglobin	EFOID:0004576	sickle cell anemia	Sickle cell disease	NA	Research Support, Non-U.S. Gov't	G	NA
2	60640807	rs11125842	A	G	rs11125842	17767159	8.30E-08	NA	NA	NA	179 adults in upper and lower 5%	NOPOP(179)	ALL(179)	NOPOP(179)	ALL(179)	F-cell distribution	HPOID:0008346	Increased red cell sickling tendency	DOID:10923	sickle cell anemia	D005319	Fetal Hemoglobin	EFOID:0004576	sickle cell anemia	Sickle cell disease	NA	Research Support, Non-U.S. Gov't	G	NA
2	60641329	rs13028240	G	A	rs13028240	17767159	1.40E-05	NA	NA	NA	179 adults in upper and lower 5%	NOPOP(179)	ALL(179)	NOPOP(179)	ALL(179)	F-cell distribution	HPOID:0008346	Increased red cell sickling tendency	DOID:10923	sickle cell anemia	D005319	Fetal Hemoglobin	EFOID:0004576	sickle cell anemia	Sickle cell disease	NA	Research Support, Non-U.S. Gov't	G	NA
2	60649143	rs12997266	G	A	rs12997266	17767159	1.90E-09	NA	NA	NA	179 adults in upper and lower 5%	NOPOP(179)	ALL(179)	NOPOP(179)	ALL(179)	F-cell distribution	HPOID:0008346	Increased red cell sickling tendency	DOID:10923	sickle cell anemia	D005319	Fetal Hemoglobin	EFOID:0004576	sickle cell anemia	Sickle cell disease	NA	Research Support, Non-U.S. Gov't	G	LOC100506891
2	60650716	rs12104736	C	G	rs12104736	17767159	9.00E-09	NA	NA	NA	179 adults in upper and lower 5%	NOPOP(179)	ALL(179)	NOPOP(179)	ALL(179)	F-cell distribution	HPOID:0008346	Increased red cell sickling tendency	DOID:10923	sickle cell anemia	D005319	Fetal Hemoglobin	EFOID:0004576	sickle cell anemia	Sickle cell disease	NA	Research Support, Non-U.S. Gov't	C	LOC100506891
2	60652061	rs13013119	C	T	rs13013119	17767159	3.70E-05	NA	NA	NA	179 adults in upper and lower 5%	NOPOP(179)	ALL(179)	NOPOP(179)	ALL(179)	F-cell distribution	HPOID:0008346	Increased red cell sickling tendency	DOID:10923	sickle cell anemia	D005319	Fetal Hemoglobin	EFOID:0004576	sickle cell anemia	Sickle cell disease	NA	Research Support, Non-U.S. Gov't	C	NA
2	60655679	rs10490070	A	G	rs10490070	17767159	9.60E-05	NA	NA	NA	179 adults in upper and lower 5%	NOPOP(179)	ALL(179)	NOPOP(179)	ALL(179)	F-cell distribution	HPOID:0008346	Increased red cell sickling tendency	DOID:10923	sickle cell anemia	D005319	Fetal Hemoglobin	EFOID:0004576	sickle cell anemia	Sickle cell disease	NA	Research Support, Non-U.S. Gov't	G	NA
2	60656992	rs13011256	G	A	rs13011256	17767159	4.50E-05	NA	NA	NA	179 adults in upper and lower 5%	NOPOP(179)	ALL(179)	NOPOP(179)	ALL(179)	F-cell distribution	HPOID:0008346	Increased red cell sickling tendency	DOID:10923	sickle cell anemia	D005319	Fetal Hemoglobin	EFOID:0004576	sickle cell anemia	Sickle cell disease	NA	Research Support, Non-U.S. Gov't	G	NA
2	60657018	rs11894442	T	C	rs11894442	17767159	3.60E-08	NA	NA	NA	179 adults in upper and lower 5%	NOPOP(179)	ALL(179)	NOPOP(179)	ALL(179)	F-cell distribution	HPOID:0008346	Increased red cell sickling tendency	DOID:10923	sickle cell anemia	D005319	Fetal Hemoglobin	EFOID:0004576	sickle cell anemia	Sickle cell disease	NA	Research Support, Non-U.S. Gov't	C	NA
2	60659307	rs6718203	C	G	rs6718203	17767159	7.00E-04	NA	NA	NA	179 adults in upper and lower 5%	NOPOP(179)	ALL(179)	NOPOP(179)	ALL(179)	F-cell distribution	HPOID:0008346	Increased red cell sickling tendency	DOID:10923	sickle cell anemia	D005319	Fetal Hemoglobin	EFOID:0004576	sickle cell anemia	Sickle cell disease	NA	Research Support, Non-U.S. Gov't	C	NA
2	60660308	rs17402905	T	C	rs17402905	17767159	8.00E-05	NA	NA	NA	179 adults in upper and lower 5%	NOPOP(179)	ALL(179)	NOPOP(179)	ALL(179)	F-cell distribution	HPOID:0008346	Increased red cell sickling tendency	DOID:10923	sickle cell anemia	D005319	Fetal Hemoglobin	EFOID:0004576	sickle cell anemia	Sickle cell disease	NA	Research Support, Non-U.S. Gov't	C	NA
2	60660522	rs17402912	A	G	rs17402912	17767159	4.60E-05	NA	NA	NA	179 adults in upper and lower 5%	NOPOP(179)	ALL(179)	NOPOP(179)	ALL(179)	F-cell distribution	HPOID:0008346	Increased red cell sickling tendency	DOID:10923	sickle cell anemia	D005319	Fetal Hemoglobin	EFOID:0004576	sickle cell anemia	Sickle cell disease	NA	Research Support, Non-U.S. Gov't	G	NA
2	60662149	rs17331017	C	A	rs17331017	17767159	6.40E-05	NA	NA	NA	179 adults in upper and lower 5%	NOPOP(179)	ALL(179)	NOPOP(179)	ALL(179)	F-cell distribution	HPOID:0008346	Increased red cell sickling tendency	DOID:10923	sickle cell anemia	D005319	Fetal Hemoglobin	EFOID:0004576	sickle cell anemia	Sickle cell disease	NA	Research Support, Non-U.S. Gov't	C	NA
2	60665768	rs1011407	A	G	rs1011407	17767159	4.10E-04	NA	NA	NA	179 adults in upper and lower 5%	NOPOP(179)	ALL(179)	NOPOP(179)	ALL(179)	F-cell distribution	HPOID:0008346	Increased red cell sickling tendency	DOID:10923	sickle cell anemia	D005319	Fetal Hemoglobin	EFOID:0004576	sickle cell anemia	Sickle cell disease	NA	Research Support, Non-U.S. Gov't	T	NA
2	60666075	rs1011406	C	G	rs1011406	17767159	6.90E-04	NA	NA	NA	179 adults in upper and lower 5%	NOPOP(179)	ALL(179)	NOPOP(179)	ALL(179)	F-cell distribution	HPOID:0008346	Increased red cell sickling tendency	DOID:10923	sickle cell anemia	D005319	Fetal Hemoglobin	EFOID:0004576	sickle cell anemia	Sickle cell disease	NA	Research Support, Non-U.S. Gov't	G	NA
2	60668890	rs10490071	G	A	rs10490071	17767159	5.30E-05	NA	NA	NA	179 adults in upper and lower 5%	NOPOP(179)	ALL(179)	NOPOP(179)	ALL(179)	F-cell distribution	HPOID:0008346	Increased red cell sickling tendency	DOID:10923	sickle cell anemia	D005319	Fetal Hemoglobin	EFOID:0004576	sickle cell anemia	Sickle cell disease	NA	Research Support, Non-U.S. Gov't	G	NA
2	60669494	rs11884411	T	C	rs11884411	17767159	1.90E-09	NA	NA	NA	179 adults in upper and lower 5%	NOPOP(179)	ALL(179)	NOPOP(179)	ALL(179)	F-cell distribution	HPOID:0008346	Increased red cell sickling tendency	DOID:10923	sickle cell anemia	D005319	Fetal Hemoglobin	EFOID:0004576	sickle cell anemia	Sickle cell disease	NA	Research Support, Non-U.S. Gov't	C	NA
2	60669931	rs10490072	T	C	rs10490072	17767159	3.10E-04	NA	NA	NA	179 adults in upper and lower 5%	NOPOP(179)	ALL(179)	NOPOP(179)	ALL(179)	F-cell distribution	HPOID:0008346	Increased red cell sickling tendency	DOID:10923	sickle cell anemia	D005319	Fetal Hemoglobin	EFOID:0004576	sickle cell anemia	Sickle cell disease	NA	Research Support, Non-U.S. Gov't	T	NA
2	60670477	rs12468946	A	G	rs12468946	17767159	7.30E-09	NA	NA	NA	179 adults in upper and lower 5%	NOPOP(179)	ALL(179)	NOPOP(179)	ALL(179)	F-cell distribution	HPOID:0008346	Increased red cell sickling tendency	DOID:10923	sickle cell anemia	D005319	Fetal Hemoglobin	EFOID:0004576	sickle cell anemia	Sickle cell disease	NA	Research Support, Non-U.S. Gov't	G	NA
2	60671339	rs17028192	C	T	rs17028192	17767159	3.10E-04	NA	NA	NA	179 adults in upper and lower 5%	NOPOP(179)	ALL(179)	NOPOP(179)	ALL(179)	F-cell distribution	HPOID:0008346	Increased red cell sickling tendency	DOID:10923	sickle cell anemia	D005319	Fetal Hemoglobin	EFOID:0004576	sickle cell anemia	Sickle cell disease	NA	Research Support, Non-U.S. Gov't	C	NA
2	60672255	rs13034649	C	T	rs13034649	17767159	5.70E-05	NA	NA	NA	179 adults in upper and lower 5%	NOPOP(179)	ALL(179)	NOPOP(179)	ALL(179)	F-cell distribution	HPOID:0008346	Increased red cell sickling tendency	DOID:10923	sickle cell anemia	D005319	Fetal Hemoglobin	EFOID:0004576	sickle cell anemia	Sickle cell disease	NA	Research Support, Non-U.S. Gov't	C	NA
2	60679942	rs17331129	T	C	rs17331129	17767159	1.00E-05	NA	NA	NA	179 adults in upper and lower 5%	NOPOP(179)	ALL(179)	NOPOP(179)	ALL(179)	F-cell distribution	HPOID:0008346	Increased red cell sickling tendency	DOID:10923	sickle cell anemia	D005319	Fetal Hemoglobin	EFOID:0004576	sickle cell anemia	Sickle cell disease	NA	Research Support, Non-U.S. Gov't	T	BCL11A
2	60698397	rs12477097	A	C	rs12477097	17767159	4.10E-04	NA	NA	NA	179 adults in upper and lower 5%	NOPOP(179)	ALL(179)	NOPOP(179)	ALL(179)	F-cell distribution	HPOID:0008346	Increased red cell sickling tendency	DOID:10923	sickle cell anemia	D005319	Fetal Hemoglobin	EFOID:0004576	sickle cell anemia	Sickle cell disease	NA	Research Support, Non-U.S. Gov't	A	BCL11A
2	60702766	rs733628	T	C	rs733628	17767159	5.70E-04	NA	NA	NA	179 adults in upper and lower 5%	NOPOP(179)	ALL(179)	NOPOP(179)	ALL(179)	F-cell distribution	HPOID:0008346	Increased red cell sickling tendency	DOID:10923	sickle cell anemia	D005319	Fetal Hemoglobin	EFOID:0004576	sickle cell anemia	Sickle cell disease	NA	Research Support, Non-U.S. Gov't	A	BCL11A
2	60705608	rs34737760	C	G	rs34737760	17767159	2.50E-04	NA	NA	NA	179 adults in upper and lower 5%	NOPOP(179)	ALL(179)	NOPOP(179)	ALL(179)	F-cell distribution	HPOID:0008346	Increased red cell sickling tendency	DOID:10923	sickle cell anemia	D005319	Fetal Hemoglobin	EFOID:0004576	sickle cell anemia	Sickle cell disease	NA	Research Support, Non-U.S. Gov't	G	BCL11A
2	60706259	rs45445891	T	G	rs45445891	17767159	3.90E-04	NA	NA	NA	179 adults in upper and lower 5%	NOPOP(179)	ALL(179)	NOPOP(179)	ALL(179)	F-cell distribution	HPOID:0008346	Increased red cell sickling tendency	DOID:10923	sickle cell anemia	D005319	Fetal Hemoglobin	EFOID:0004576	sickle cell anemia	Sickle cell disease	NA	Research Support, Non-U.S. Gov't	G	BCL11A
2	60707038	rs12992182	C	A	rs12992182	17767159	2.50E-04	NA	NA	NA	179 adults in upper and lower 5%	NOPOP(179)	ALL(179)	NOPOP(179)	ALL(179)	F-cell distribution	HPOID:0008346	Increased red cell sickling tendency	DOID:10923	sickle cell anemia	D005319	Fetal Hemoglobin	EFOID:0004576	sickle cell anemia	Sickle cell disease	NA	Research Support, Non-U.S. Gov't	C	BCL11A
2	60707182	rs12997966	G	A	rs12997966	17767159	2.10E-04	NA	NA	NA	179 adults in upper and lower 5%	NOPOP(179)	ALL(179)	NOPOP(179)	ALL(179)	F-cell distribution	HPOID:0008346	Increased red cell sickling tendency	DOID:10923	sickle cell anemia	D005319	Fetal Hemoglobin	EFOID:0004576	sickle cell anemia	Sickle cell disease	NA	Research Support, Non-U.S. Gov't	G	BCL11A
2	60707894	rs7579014	G	A	rs7579014	17767159	1.20E-06	NA	NA	NA	179 adults in upper and lower 5%	NOPOP(179)	ALL(179)	NOPOP(179)	ALL(179)	F-cell distribution	HPOID:0008346	Increased red cell sickling tendency	DOID:10923	sickle cell anemia	D005319	Fetal Hemoglobin	EFOID:0004576	sickle cell anemia	Sickle cell disease	NA	Research Support, Non-U.S. Gov't	A	BCL11A
2	60707941	rs35908689	C	G	rs35908689	17767159	2.50E-04	NA	NA	NA	179 adults in upper and lower 5%	NOPOP(179)	ALL(179)	NOPOP(179)	ALL(179)	F-cell distribution	HPOID:0008346	Increased red cell sickling tendency	DOID:10923	sickle cell anemia	D005319	Fetal Hemoglobin	EFOID:0004576	sickle cell anemia	Sickle cell disease	NA	Research Support, Non-U.S. Gov't	C	BCL11A
2	60708597	rs6732518	C	T	rs6732518	17767159	1.10E-21	NA	NA	NA	179 adults in upper and lower 5%	NOPOP(179)	ALL(179)	NOPOP(179)	ALL(179)	F-cell distribution	HPOID:0008346	Increased red cell sickling tendency	DOID:10923	sickle cell anemia	D005319	Fetal Hemoglobin	EFOID:0004576	sickle cell anemia	Sickle cell disease	NA	Research Support, Non-U.S. Gov't	C	BCL11A
2	60708597	rs6732518	C	T	rs6732518	21326311	2.87E-09	NA	NA	NA	440 African ancestry individuals	African(440)	ALL(440)	AFR(440)	ALL(440)	F-cell distribution	HPOID:0008346	Increased red cell sickling tendency	DOID:10923	sickle cell anemia	D005319	Fetal Hemoglobin	EFOID:0004576	sickle cell anemia	Sickle cell disease	NA	Research Support, N.I.H., Extramural	C	BCL11A
2	60710571	rs13019832	G	A	rs13019832	17767159	7.60E-12	NA	NA	NA	179 adults in upper and lower 5%	NOPOP(179)	ALL(179)	NOPOP(179)	ALL(179)	F-cell distribution	HPOID:0008346	Increased red cell sickling tendency	DOID:10923	sickle cell anemia	D005319	Fetal Hemoglobin	EFOID:0004576	sickle cell anemia	Sickle cell disease	NA	Research Support, Non-U.S. Gov't	A	BCL11A
2	60710738	rs11692396	G	A	rs11692396	17767159	7.90E-12	NA	NA	NA	179 adults in upper and lower 5%	NOPOP(179)	ALL(179)	NOPOP(179)	ALL(179)	F-cell distribution	HPOID:0008346	Increased red cell sickling tendency	DOID:10923	sickle cell anemia	D005319	Fetal Hemoglobin	EFOID:0004576	sickle cell anemia	Sickle cell disease	NA	Research Support, Non-U.S. Gov't	A	BCL11A
2	60713235	rs10189857	A	G	rs10189857	21326311	2.00E-07	NA	1.07	[0.68-1.46] unit increase	440 African ancestry individuals	African(440)	ALL(440)	AFR(440)	ALL(440)	F-cell distribution	HPOID:0008346	Increased red cell sickling tendency	DOID:10923	sickle cell anemia	D005319	Fetal Hemoglobin	EFOID:0004576	sickle cell anemia	Sickle cell disease	NA	Research Support, N.I.H., Extramural	A	BCL11A
2	60714861	rs6545816	A	C	rs6545816	21326311	2.00E-07	NA	NA	NA	440 African ancestry individuals	African(440)	ALL(440)	AFR(440)	ALL(440)	F-cell distribution	HPOID:0008346	Increased red cell sickling tendency	DOID:10923	sickle cell anemia	D005319	Fetal Hemoglobin	EFOID:0004576	sickle cell anemia	Sickle cell disease	NA	Research Support, N.I.H., Extramural	A	BCL11A
2	60715179	rs6545817	C	T	rs6545817	21326311	2.00E-07	NA	NA	NA	440 African ancestry individuals	African(440)	ALL(440)	AFR(440)	ALL(440)	F-cell distribution	HPOID:0008346	Increased red cell sickling tendency	DOID:10923	sickle cell anemia	D005319	Fetal Hemoglobin	EFOID:0004576	sickle cell anemia	Sickle cell disease	NA	Research Support, N.I.H., Extramural	C	BCL11A
2	60716308	rs13024177	G	C	rs13024177	17767159	5.90E-04	NA	NA	NA	179 adults in upper and lower 5%	NOPOP(179)	ALL(179)	NOPOP(179)	ALL(179)	F-cell distribution	HPOID:0008346	Increased red cell sickling tendency	DOID:10923	sickle cell anemia	D005319	Fetal Hemoglobin	EFOID:0004576	sickle cell anemia	Sickle cell disease	NA	Research Support, Non-U.S. Gov't	G	BCL11A
2	60717399	rs13031396	G	T	rs13031396	17767159	2.10E-04	NA	NA	NA	179 adults in upper and lower 5%	NOPOP(179)	ALL(179)	NOPOP(179)	ALL(179)	F-cell distribution	HPOID:0008346	Increased red cell sickling tendency	DOID:10923	sickle cell anemia	D005319	Fetal Hemoglobin	EFOID:0004576	sickle cell anemia	Sickle cell disease	NA	Research Support, Non-U.S. Gov't	G	BCL11A
2	60718043	rs1427407	T	G	rs1427407	17767159	6.00E-31	NA	13.1	NA	179 adults in upper and lower 5%	NOPOP(179)	ALL(179)	NOPOP(179)	ALL(179)	F-cell distribution	HPOID:0008346	Increased red cell sickling tendency	DOID:10923	sickle cell anemia	D005319	Fetal Hemoglobin	EFOID:0004576	sickle cell anemia	Sickle cell disease	NA	Research Support, Non-U.S. Gov't	G	BCL11A
2	60718043	rs1427407	T	G	rs1427407	21326311	2.00E-07	NA	NA	NA	440 African ancestry individuals	African(440)	ALL(440)	AFR(440)	ALL(440)	F-cell distribution	HPOID:0008346	Increased red cell sickling tendency	DOID:10923	sickle cell anemia	D005319	Fetal Hemoglobin	EFOID:0004576	sickle cell anemia	Sickle cell disease	NA	Research Support, N.I.H., Extramural	G	BCL11A
2	60718347	rs7599488	C	T	rs7599488	21326311	2.00E-07	NA	NA	NA	440 African ancestry individuals	African(440)	ALL(440)	AFR(440)	ALL(440)	F-cell distribution	HPOID:0008346	Increased red cell sickling tendency	DOID:10923	sickle cell anemia	D005319	Fetal Hemoglobin	EFOID:0004576	sickle cell anemia	Sickle cell disease	NA	Research Support, N.I.H., Extramural	C	BCL11A
2	60718848	rs1896293	G	T	rs1896293	17767159	2.00E-07	NA	NA	NA	179 adults in upper and lower 5%	NOPOP(179)	ALL(179)	NOPOP(179)	ALL(179)	F-cell distribution	HPOID:0008346	Increased red cell sickling tendency	DOID:10923	sickle cell anemia	D005319	Fetal Hemoglobin	EFOID:0004576	sickle cell anemia	Sickle cell disease	NA	Research Support, Non-U.S. Gov't	G	BCL11A
2	60719074	rs1896294	C	T	rs1896294	17767159	1.70E-10	NA	NA	NA	179 adults in upper and lower 5%	NOPOP(179)	ALL(179)	NOPOP(179)	ALL(179)	F-cell distribution	HPOID:0008346	Increased red cell sickling tendency	DOID:10923	sickle cell anemia	D005319	Fetal Hemoglobin	EFOID:0004576	sickle cell anemia	Sickle cell disease	NA	Research Support, Non-U.S. Gov't	T	BCL11A
2	60719074	rs1896294	C	T	rs1896294	21326311	2.00E-07	NA	NA	NA	440 African ancestry individuals	African(440)	ALL(440)	AFR(440)	ALL(440)	F-cell distribution	HPOID:0008346	Increased red cell sickling tendency	DOID:10923	sickle cell anemia	D005319	Fetal Hemoglobin	EFOID:0004576	sickle cell anemia	Sickle cell disease	NA	Research Support, N.I.H., Extramural	T	BCL11A
2	60719918	rs766431	A	G	rs766431	17767159	2.70E-07	NA	NA	NA	179 adults in upper and lower 5%	NOPOP(179)	ALL(179)	NOPOP(179)	ALL(179)	F-cell distribution	HPOID:0008346	Increased red cell sickling tendency	DOID:10923	sickle cell anemia	D005319	Fetal Hemoglobin	EFOID:0004576	sickle cell anemia	Sickle cell disease	NA	Research Support, Non-U.S. Gov't	A	BCL11A
2	60719970	rs766432	C	A	rs766432	17767159	1.80E-28	NA	NA	NA	179 adults in upper and lower 5%	NOPOP(179)	ALL(179)	NOPOP(179)	ALL(179)	F-cell distribution	HPOID:0008346	Increased red cell sickling tendency	DOID:10923	sickle cell anemia	D005319	Fetal Hemoglobin	EFOID:0004576	sickle cell anemia	Sickle cell disease	NA	Research Support, Non-U.S. Gov't	A	BCL11A
2	60719970	rs766432	C	A	rs766432	21326311	2.00E-07	NA	NA	NA	440 African ancestry individuals	African(440)	ALL(440)	AFR(440)	ALL(440)	F-cell distribution	HPOID:0008346	Increased red cell sickling tendency	DOID:10923	sickle cell anemia	D005319	Fetal Hemoglobin	EFOID:0004576	sickle cell anemia	Sickle cell disease	NA	Research Support, N.I.H., Extramural	A	BCL11A
2	60719970	rs766432	C	A	rs766432	23406172	9.00E-07	NA	0.22	[NA] unit increase	1,117 individuals	NOPOP(1117)	ALL(1117)	NOPOP(1117)	ALL(1117)	Sickle cell anemia (haemolysis)	HPOID:0008346	Increased red cell sickling tendency	DOID:10923	sickle cell anemia	NA	NA	sickle cell anemia	Sickle cell disease	NA	Multicenter Study	Clinical Trial	Research Support, N.I.H., Extramural	Research Support, Non-U.S. Gov't
2	60720246	rs11886868	C	T	rs11886868	17767159	4.20E-11	NA	NA	NA	179 adults in upper and lower 5%	NOPOP(179)	ALL(179)	NOPOP(179)	ALL(179)	F-cell distribution	HPOID:0008346	Increased red cell sickling tendency	DOID:10923	sickle cell anemia	D005319	Fetal Hemoglobin	EFOID:0004576	sickle cell anemia	Sickle cell disease	NA	Research Support, Non-U.S. Gov't	T	BCL11A
2	60720246	rs11886868	C	T	rs11886868	21326311	2.00E-07	NA	NA	NA	440 African ancestry individuals	African(440)	ALL(440)	AFR(440)	ALL(440)	F-cell distribution	HPOID:0008346	Increased red cell sickling tendency	DOID:10923	sickle cell anemia	D005319	Fetal Hemoglobin	EFOID:0004576	sickle cell anemia	Sickle cell disease	NA	Research Support, N.I.H., Extramural	T	BCL11A
2	60720589	rs10195871	A	G	rs10195871	17767159	5.40E-11	NA	NA	NA	179 adults in upper and lower 5%	NOPOP(179)	ALL(179)	NOPOP(179)	ALL(179)	F-cell distribution	HPOID:0008346	Increased red cell sickling tendency	DOID:10923	sickle cell anemia	D005319	Fetal Hemoglobin	EFOID:0004576	sickle cell anemia	Sickle cell disease	NA	Research Support, Non-U.S. Gov't	G	BCL11A
2	60720589	rs10195871	A	G	rs10195871	21326311	2.00E-07	NA	NA	NA	440 African ancestry individuals	African(440)	ALL(440)	AFR(440)	ALL(440)	F-cell distribution	HPOID:0008346	Increased red cell sickling tendency	DOID:10923	sickle cell anemia	D005319	Fetal Hemoglobin	EFOID:0004576	sickle cell anemia	Sickle cell disease	NA	Research Support, N.I.H., Extramural	G	BCL11A
2	60720757	rs10172646	G	A	rs10172646	17767159	4.30E-11	NA	NA	NA	179 adults in upper and lower 5%	NOPOP(179)	ALL(179)	NOPOP(179)	ALL(179)	F-cell distribution	HPOID:0008346	Increased red cell sickling tendency	DOID:10923	sickle cell anemia	D005319	Fetal Hemoglobin	EFOID:0004576	sickle cell anemia	Sickle cell disease	NA	Research Support, Non-U.S. Gov't	A	BCL11A
2	60720757	rs10172646	G	A	rs10172646	21326311	2.00E-07	NA	NA	NA	440 African ancestry individuals	African(440)	ALL(440)	AFR(440)	ALL(440)	F-cell distribution	HPOID:0008346	Increased red cell sickling tendency	DOID:10923	sickle cell anemia	D005319	Fetal Hemoglobin	EFOID:0004576	sickle cell anemia	Sickle cell disease	NA	Research Support, N.I.H., Extramural	A	BCL11A
2	60720951	rs4671393	A	G	rs4671393	17767159	2.60E-27	NA	NA	NA	179 adults in upper and lower 5%	NOPOP(179)	ALL(179)	NOPOP(179)	ALL(179)	F-cell distribution	HPOID:0008346	Increased red cell sickling tendency	DOID:10923	sickle cell anemia	D005319	Fetal Hemoglobin	EFOID:0004576	sickle cell anemia	Sickle cell disease	NA	Research Support, Non-U.S. Gov't	G	BCL11A
2	60720951	rs4671393	A	G	rs4671393	21326311	2.00E-07	NA	NA	NA	440 African ancestry individuals	African(440)	ALL(440)	AFR(440)	ALL(440)	F-cell distribution	HPOID:0008346	Increased red cell sickling tendency	DOID:10923	sickle cell anemia	D005319	Fetal Hemoglobin	EFOID:0004576	sickle cell anemia	Sickle cell disease	NA	Research Support, N.I.H., Extramural	G	BCL11A
2	60721311	rs7584113	A	G	rs7584113	17767159	2.90E-10	NA	NA	NA	179 adults in upper and lower 5%	NOPOP(179)	ALL(179)	NOPOP(179)	ALL(179)	F-cell distribution	HPOID:0008346	Increased red cell sickling tendency	DOID:10923	sickle cell anemia	D005319	Fetal Hemoglobin	EFOID:0004576	sickle cell anemia	Sickle cell disease	NA	Research Support, Non-U.S. Gov't	G	BCL11A
2	60721311	rs7584113	A	G	rs7584113	21326311	2.00E-07	NA	NA	NA	440 African ancestry individuals	African(440)	ALL(440)	AFR(440)	ALL(440)	F-cell distribution	HPOID:0008346	Increased red cell sickling tendency	DOID:10923	sickle cell anemia	D005319	Fetal Hemoglobin	EFOID:0004576	sickle cell anemia	Sickle cell disease	NA	Research Support, N.I.H., Extramural	G	BCL11A
2	60721347	rs7557939	G	A	rs7557939	17767159	4.60E-11	NA	NA	NA	179 adults in upper and lower 5%	NOPOP(179)	ALL(179)	NOPOP(179)	ALL(179)	F-cell distribution	HPOID:0008346	Increased red cell sickling tendency	DOID:10923	sickle cell anemia	D005319	Fetal Hemoglobin	EFOID:0004576	sickle cell anemia	Sickle cell disease	NA	Research Support, Non-U.S. Gov't	G	BCL11A
2	60721347	rs7557939	G	A	rs7557939	21326311	2.00E-07	NA	NA	NA	440 African ancestry individuals	African(440)	ALL(440)	AFR(440)	ALL(440)	F-cell distribution	HPOID:0008346	Increased red cell sickling tendency	DOID:10923	sickle cell anemia	D005319	Fetal Hemoglobin	EFOID:0004576	sickle cell anemia	Sickle cell disease	NA	Research Support, N.I.H., Extramural	G	BCL11A
2	60722040	rs6706648	C	T	rs6706648	17767159	9.30E-08	NA	NA	NA	179 adults in upper and lower 5%	NOPOP(179)	ALL(179)	NOPOP(179)	ALL(179)	F-cell distribution	HPOID:0008346	Increased red cell sickling tendency	DOID:10923	sickle cell anemia	D005319	Fetal Hemoglobin	EFOID:0004576	sickle cell anemia	Sickle cell disease	NA	Research Support, Non-U.S. Gov't	T	BCL11A
2	60722040	rs6706648	C	T	rs6706648	21326311	2.00E-07	NA	NA	NA	440 African ancestry individuals	African(440)	ALL(440)	AFR(440)	ALL(440)	F-cell distribution	HPOID:0008346	Increased red cell sickling tendency	DOID:10923	sickle cell anemia	D005319	Fetal Hemoglobin	EFOID:0004576	sickle cell anemia	Sickle cell disease	NA	Research Support, N.I.H., Extramural	T	BCL11A
2	60722241	rs6738440	A	G	rs6738440	17767159	6.00E-06	NA	NA	NA	179 adults in upper and lower 5%	NOPOP(179)	ALL(179)	NOPOP(179)	ALL(179)	F-cell distribution	HPOID:0008346	Increased red cell sickling tendency	DOID:10923	sickle cell anemia	D005319	Fetal Hemoglobin	EFOID:0004576	sickle cell anemia	Sickle cell disease	NA	Research Support, Non-U.S. Gov't	A	BCL11A
2	60722241	rs6738440	A	G	rs6738440	21326311	2.00E-07	NA	NA	NA	440 African ancestry individuals	African(440)	ALL(440)	AFR(440)	ALL(440)	F-cell distribution	HPOID:0008346	Increased red cell sickling tendency	DOID:10923	sickle cell anemia	D005319	Fetal Hemoglobin	EFOID:0004576	sickle cell anemia	Sickle cell disease	NA	Research Support, N.I.H., Extramural	A	BCL11A
2	60723266	rs7565301	G	A	rs7565301	21326311	2.00E-07	NA	NA	NA	440 African ancestry individuals	African(440)	ALL(440)	AFR(440)	ALL(440)	F-cell distribution	HPOID:0008346	Increased red cell sickling tendency	DOID:10923	sickle cell anemia	D005319	Fetal Hemoglobin	EFOID:0004576	sickle cell anemia	Sickle cell disease	NA	Research Support, N.I.H., Extramural	G	BCL11A
2	60723672	rs6729815	T	C	rs6729815	21326311	2.00E-07	NA	NA	NA	440 African ancestry individuals	African(440)	ALL(440)	AFR(440)	ALL(440)	F-cell distribution	HPOID:0008346	Increased red cell sickling tendency	DOID:10923	sickle cell anemia	D005319	Fetal Hemoglobin	EFOID:0004576	sickle cell anemia	Sickle cell disease	NA	Research Support, N.I.H., Extramural	C	BCL11A
2	60724086	rs1896295	T	C	rs1896295	21326311	2.00E-07	NA	NA	NA	440 African ancestry individuals	African(440)	ALL(440)	AFR(440)	ALL(440)	F-cell distribution	HPOID:0008346	Increased red cell sickling tendency	DOID:10923	sickle cell anemia	D005319	Fetal Hemoglobin	EFOID:0004576	sickle cell anemia	Sickle cell disease	NA	Research Support, N.I.H., Extramural	C	BCL11A
2	60724087	rs1896296	G	T	rs1896296	21326311	2.00E-07	NA	NA	NA	440 African ancestry individuals	African(440)	ALL(440)	AFR(440)	ALL(440)	F-cell distribution	HPOID:0008346	Increased red cell sickling tendency	DOID:10923	sickle cell anemia	D005319	Fetal Hemoglobin	EFOID:0004576	sickle cell anemia	Sickle cell disease	NA	Research Support, N.I.H., Extramural	T	BCL11A
2	60725451	rs7606173	G	C	rs7606173	21326311	2.00E-07	NA	NA	NA	440 African ancestry individuals	African(440)	ALL(440)	AFR(440)	ALL(440)	F-cell distribution	HPOID:0008346	Increased red cell sickling tendency	DOID:10923	sickle cell anemia	D005319	Fetal Hemoglobin	EFOID:0004576	sickle cell anemia	Sickle cell disease	NA	Research Support, N.I.H., Extramural	G	BCL11A
2	60727629	rs6709302	G	A	rs6709302	17767159	1.10E-05	NA	NA	NA	179 adults in upper and lower 5%	NOPOP(179)	ALL(179)	NOPOP(179)	ALL(179)	F-cell distribution	HPOID:0008346	Increased red cell sickling tendency	DOID:10923	sickle cell anemia	D005319	Fetal Hemoglobin	EFOID:0004576	sickle cell anemia	Sickle cell disease	NA	Research Support, Non-U.S. Gov't	G	BCL11A
2	60727629	rs6709302	G	A	rs6709302	21326311	8.90E-10	NA	NA	NA	440 African ancestry individuals	African(440)	ALL(440)	AFR(440)	ALL(440)	F-cell distribution	HPOID:0008346	Increased red cell sickling tendency	DOID:10923	sickle cell anemia	D005319	Fetal Hemoglobin	EFOID:0004576	sickle cell anemia	Sickle cell disease	NA	Research Support, N.I.H., Extramural	G	BCL11A
2	66878488	rs11695019	A	G	rs11695019	21326311	3.32E-05	NA	NA	NA	440 African ancestry individuals	African(440)	ALL(440)	AFR(440)	ALL(440)	F-cell distribution	HPOID:0008346	Increased red cell sickling tendency	DOID:10923	sickle cell anemia	D005319	Fetal Hemoglobin	EFOID:0004576	sickle cell anemia	Sickle cell disease	NA	Research Support, N.I.H., Extramural	A	NA
2	73574591	rs6718864	A	G	rs6718864	21326311	9.03E-06	NA	NA	NA	440 African ancestry individuals	African(440)	ALL(440)	AFR(440)	ALL(440)	F-cell distribution	HPOID:0008346	Increased red cell sickling tendency	DOID:10923	sickle cell anemia	D005319	Fetal Hemoglobin	EFOID:0004576	sickle cell anemia	Sickle cell disease	NA	Research Support, N.I.H., Extramural	G	NA
2	75075255	rs680545	G	A	rs680545	20029952	5.92E-06	Sickle cell anemia severity	NA	NA	177 African American severe patients; 1088 African American mild patients	African American(1265)	ALL(1265)	AFR(1265)	ALL(1265)	Sickle cell anemia (severity)	HPOID:0008346	Increased red cell sickling tendency	DOID:10923	sickle cell anemia	NA	NA	NA	NA	Sickle cell disease	NA	Research Support, N.I.H., Extramural	T	HK2
2	114001363	rs3768768	A	G	rs3768768	21326311	2.32E-05	NA	NA	NA	440 African ancestry individuals	African(440)	ALL(440)	AFR(440)	ALL(440)	F-cell distribution	HPOID:0008346	Increased red cell sickling tendency	DOID:10923	sickle cell anemia	D005319	Fetal Hemoglobin	EFOID:0004576	sickle cell anemia	Sickle cell disease	NA	Research Support, N.I.H., Extramural	C	PAX8
2	234668570	rs887829	C	T	rs887829	22558097	5.00E-25	NA	0.19	[NA] unit increase	905 African American cases	African American(905)	ALL(905)	AFR(905)	ALL(905)	Cholelithiasis-related traits in sickle cell anemia	HPOID:0001081	HPOID:0008346	Cholelithiasis	Increased red cell sickling tendency	DOID:10923	sickle cell anemia	D012805	Sickle Cell Trait	EFOID:0004799	sickle cell anemia	Sickle cell disease	rs887829-A	Research Support, N.I.H., Extramural
3	50525017	rs1467913	C	A	rs1467913	21326311	5.19E-06	NA	NA	NA	440 African ancestry individuals	African(440)	ALL(440)	AFR(440)	ALL(440)	F-cell distribution	HPOID:0008346	Increased red cell sickling tendency	DOID:10923	sickle cell anemia	D005319	Fetal Hemoglobin	EFOID:0004576	sickle cell anemia	Sickle cell disease	NA	Research Support, N.I.H., Extramural	T	CACNA2D2
3	56877788	rs10510789	C	T	rs10510789	21326311	1.45E-05	NA	NA	NA	440 African ancestry individuals	African(440)	ALL(440)	AFR(440)	ALL(440)	F-cell distribution	HPOID:0008346	Increased red cell sickling tendency	DOID:10923	sickle cell anemia	D005319	Fetal Hemoglobin	EFOID:0004576	sickle cell anemia	Sickle cell disease	NA	Research Support, N.I.H., Extramural	C	ARHGEF3
3	57186035	rs4535195	A	C	rs4535195	17767159	1.00E-05	NA	NA	NA	179 adults in upper and lower 5%	NOPOP(179)	ALL(179)	NOPOP(179)	ALL(179)	F-cell distribution	HPOID:0008346	Increased red cell sickling tendency	DOID:10923	sickle cell anemia	D005319	Fetal Hemoglobin	EFOID:0004576	sickle cell anemia	Sickle cell disease	NA	Research Support, Non-U.S. Gov't	C	IL17RD
3	126220539	rs9844797	A	G	rs9844797	21326311	4.49E-05	NA	NA	NA	440 African ancestry individuals	African(440)	ALL(440)	AFR(440)	ALL(440)	F-cell distribution	HPOID:0008346	Increased red cell sickling tendency	DOID:10923	sickle cell anemia	D005319	Fetal Hemoglobin	EFOID:0004576	sickle cell anemia	Sickle cell disease	NA	Research Support, N.I.H., Extramural	G	UROC1
3	145287372	rs2695775	C	A	rs2695775	21326311	2.33E-05	NA	NA	NA	440 African ancestry individuals	African(440)	ALL(440)	AFR(440)	ALL(440)	F-cell distribution	HPOID:0008346	Increased red cell sickling tendency	DOID:10923	sickle cell anemia	D005319	Fetal Hemoglobin	EFOID:0004576	sickle cell anemia	Sickle cell disease	NA	Research Support, N.I.H., Extramural	A	NA
3	161544997	rs13061797	T	C	rs13061797	20029952	1.28E-06	Sickle cell anemia severity	NA	NA	177 African American severe patients; 1088 African American mild patients	African American(1265)	ALL(1265)	AFR(1265)	ALL(1265)	Sickle cell anemia (severity)	HPOID:0008346	Increased red cell sickling tendency	DOID:10923	sickle cell anemia	NA	NA	NA	NA	Sickle cell disease	NA	Research Support, N.I.H., Extramural	T	NA
4	6168155	rs6446469	A	G	rs6446469	21326311	3.60E-05	NA	NA	NA	440 African ancestry individuals	African(440)	ALL(440)	AFR(440)	ALL(440)	F-cell distribution	HPOID:0008346	Increased red cell sickling tendency	DOID:10923	sickle cell anemia	D005319	Fetal Hemoglobin	EFOID:0004576	sickle cell anemia	Sickle cell disease	NA	Research Support, N.I.H., Extramural	G	JAKMIP1
4	7174993	rs9999241	A	G	rs9999241	17767159	1.00E-05	NA	NA	NA	179 adults in upper and lower 5%	NOPOP(179)	ALL(179)	NOPOP(179)	ALL(179)	F-cell distribution	HPOID:0008346	Increased red cell sickling tendency	DOID:10923	sickle cell anemia	D005319	Fetal Hemoglobin	EFOID:0004576	sickle cell anemia	Sickle cell disease	NA	Research Support, Non-U.S. Gov't	G	NA
4	76194403	rs7696346	C	T	rs7696346	21326311	1.57E-05	NA	NA	NA	440 African ancestry individuals	African(440)	ALL(440)	AFR(440)	ALL(440)	F-cell distribution	HPOID:0008346	Increased red cell sickling tendency	DOID:10923	sickle cell anemia	D005319	Fetal Hemoglobin	EFOID:0004576	sickle cell anemia	Sickle cell disease	NA	Research Support, N.I.H., Extramural	T	NA
4	90983723	rs2120372	A	G	rs2120372	21326311	4.62E-06	NA	NA	NA	440 African ancestry individuals	African(440)	ALL(440)	AFR(440)	ALL(440)	F-cell distribution	HPOID:0008346	Increased red cell sickling tendency	DOID:10923	sickle cell anemia	D005319	Fetal Hemoglobin	EFOID:0004576	sickle cell anemia	Sickle cell disease	NA	Research Support, N.I.H., Extramural	C	NA
4	92855968	rs321717	T	C	rs321717	20029952	1.21E-06	Sickle cell anemia severity	NA	NA	177 African American severe patients; 1088 African American mild patients	African American(1265)	ALL(1265)	AFR(1265)	ALL(1265)	Sickle cell anemia (severity)	HPOID:0008346	Increased red cell sickling tendency	DOID:10923	sickle cell anemia	NA	NA	NA	NA	Sickle cell disease	NA	Research Support, N.I.H., Extramural	G	NA
4	120962385	rs1845344	G	T	rs1845344	21326311	7.00E-06	NA	0.97	[0.56-1.38] unit increase	440 African ancestry individuals	African(440)	ALL(440)	AFR(440)	ALL(440)	F-cell distribution	HPOID:0008346	Increased red cell sickling tendency	DOID:10923	sickle cell anemia	D005319	Fetal Hemoglobin	EFOID:0004576	sickle cell anemia	Sickle cell disease	rs1845344-T	Research Support, N.I.H., Extramural	G	NA
4	121481950	rs4395533	G	A	rs4395533	21326311	2.08E-05	NA	NA	NA	440 African ancestry individuals	African(440)	ALL(440)	AFR(440)	ALL(440)	F-cell distribution	HPOID:0008346	Increased red cell sickling tendency	DOID:10923	sickle cell anemia	D005319	Fetal Hemoglobin	EFOID:0004576	sickle cell anemia	Sickle cell disease	NA	Research Support, N.I.H., Extramural	A	NA
4	121513215	rs10017284	A	G	rs10017284	21326311	6.00E-06	NA	0.85	[0.50-1.20] unit decrease	440 African ancestry individuals	African(440)	ALL(440)	AFR(440)	ALL(440)	F-cell distribution	HPOID:0008346	Increased red cell sickling tendency	DOID:10923	sickle cell anemia	D005319	Fetal Hemoglobin	EFOID:0004576	sickle cell anemia	Sickle cell disease	rs10017284-G	Research Support, N.I.H., Extramural	A	NA
5	4586832	rs293064	T	C	rs293064	21326311	2.51E-05	NA	NA	NA	440 African ancestry individuals	African(440)	ALL(440)	AFR(440)	ALL(440)	F-cell distribution	HPOID:0008346	Increased red cell sickling tendency	DOID:10923	sickle cell anemia	D005319	Fetal Hemoglobin	EFOID:0004576	sickle cell anemia	Sickle cell disease	NA	Research Support, N.I.H., Extramural	C	NA
5	6788282	rs274646	A	G	rs274646	20029952	1.14E-05	Sickle cell anemia severity	NA	NA	177 African American severe patients; 1088 African American mild patients	African American(1265)	ALL(1265)	AFR(1265)	ALL(1265)	Sickle cell anemia (severity)	HPOID:0008346	Increased red cell sickling tendency	DOID:10923	sickle cell anemia	NA	NA	NA	NA	Sickle cell disease	NA	Research Support, N.I.H., Extramural	C	NA
5	9156012	rs886509	T	C	rs886509	17767159	1.00E-05	NA	NA	NA	179 adults in upper and lower 5%	NOPOP(179)	ALL(179)	NOPOP(179)	ALL(179)	F-cell distribution	HPOID:0008346	Increased red cell sickling tendency	DOID:10923	sickle cell anemia	D005319	Fetal Hemoglobin	EFOID:0004576	sickle cell anemia	Sickle cell disease	NA	Research Support, Non-U.S. Gov't	A	SEMA5A
5	26907873	rs1156358	A	G	rs1156358	20029952	1.10E-06	Sickle cell anemia severity	NA	NA	177 African American severe patients; 1088 African American mild patients	African American(1265)	ALL(1265)	AFR(1265)	ALL(1265)	Sickle cell anemia (severity)	HPOID:0008346	Increased red cell sickling tendency	DOID:10923	sickle cell anemia	NA	NA	NA	NA	Sickle cell disease	NA	Research Support, N.I.H., Extramural	T	CDH9
5	51917914	rs830868	G	T	rs830868	21326311	1.12E-05	NA	NA	NA	440 African ancestry individuals	African(440)	ALL(440)	AFR(440)	ALL(440)	F-cell distribution	HPOID:0008346	Increased red cell sickling tendency	DOID:10923	sickle cell anemia	D005319	Fetal Hemoglobin	EFOID:0004576	sickle cell anemia	Sickle cell disease	NA	Research Support, N.I.H., Extramural	T	NA
5	112723567	rs1318772	A	G	rs1318772	21326311	1.00E-06	NA	0.91	[0.54-1.28] unit decrease	440 African ancestry individuals	African(440)	ALL(440)	AFR(440)	ALL(440)	F-cell distribution	HPOID:0008346	Increased red cell sickling tendency	DOID:10923	sickle cell anemia	D005319	Fetal Hemoglobin	EFOID:0004576	sickle cell anemia	Sickle cell disease	rs1318772-G	Research Support, N.I.H., Extramural	A	MCC
5	112981528	rs12189067	C	A	rs12189067	21326311	1.13E-05	NA	NA	NA	440 African ancestry individuals	African(440)	ALL(440)	AFR(440)	ALL(440)	F-cell distribution	HPOID:0008346	Increased red cell sickling tendency	DOID:10923	sickle cell anemia	D005319	Fetal Hemoglobin	EFOID:0004576	sickle cell anemia	Sickle cell disease	NA	Research Support, N.I.H., Extramural	C	NA
5	112996654	rs17135859	T	C	rs17135859	21326311	8.00E-06	NA	0.97	[0.54-1.40] unit increase	440 African ancestry individuals	African(440)	ALL(440)	AFR(440)	ALL(440)	F-cell distribution	HPOID:0008346	Increased red cell sickling tendency	DOID:10923	sickle cell anemia	D005319	Fetal Hemoglobin	EFOID:0004576	sickle cell anemia	Sickle cell disease	rs17135859-C	Research Support, N.I.H., Extramural	T	NA
5	134493323	rs17660170	G	T	rs17660170	21326311	1.40E-05	NA	NA	NA	440 African ancestry individuals	African(440)	ALL(440)	AFR(440)	ALL(440)	F-cell distribution	HPOID:0008346	Increased red cell sickling tendency	DOID:10923	sickle cell anemia	D005319	Fetal Hemoglobin	EFOID:0004576	sickle cell anemia	Sickle cell disease	NA	Research Support, N.I.H., Extramural	G	NA
5	155809052	rs7715464	G	A	rs7715464	21326311	3.87E-06	NA	NA	NA	440 African ancestry individuals	African(440)	ALL(440)	AFR(440)	ALL(440)	F-cell distribution	HPOID:0008346	Increased red cell sickling tendency	DOID:10923	sickle cell anemia	D005319	Fetal Hemoglobin	EFOID:0004576	sickle cell anemia	Sickle cell disease	NA	Research Support, N.I.H., Extramural	G	SGCD
5	171268203	rs6891834	C	T	rs6891834	21326311	2.39E-05	NA	NA	NA	440 African ancestry individuals	African(440)	ALL(440)	AFR(440)	ALL(440)	F-cell distribution	HPOID:0008346	Increased red cell sickling tendency	DOID:10923	sickle cell anemia	D005319	Fetal Hemoglobin	EFOID:0004576	sickle cell anemia	Sickle cell disease	NA	Research Support, N.I.H., Extramural	C	NA
6	13240272	rs202062	A	G	rs202062	20029952	3.61E-06	Sickle cell anemia severity	NA	NA	177 African American severe patients; 1088 African American mild patients	African American(1265)	ALL(1265)	AFR(1265)	ALL(1265)	Sickle cell anemia (severity)	HPOID:0008346	Increased red cell sickling tendency	DOID:10923	sickle cell anemia	NA	NA	NA	NA	Sickle cell disease	NA	Research Support, N.I.H., Extramural	T	PHACTR1
6	28555450	rs411538	C	T	rs411538	20029952	2.17E-06	Sickle cell anemia severity	NA	NA	177 African American severe patients; 1088 African American mild patients	African American(1265)	ALL(1265)	AFR(1265)	ALL(1265)	Sickle cell anemia (severity)	HPOID:0008346	Increased red cell sickling tendency	DOID:10923	sickle cell anemia	NA	NA	NA	NA	Sickle cell disease	NA	Research Support, N.I.H., Extramural	C	SCAND3
6	71776971	rs11968814	G	A	rs11968814	21326311	9.00E-07	NA	1.17	[0.70-1.64] unit decrease	440 African ancestry individuals	African(440)	ALL(440)	AFR(440)	ALL(440)	F-cell distribution	HPOID:0008346	Increased red cell sickling tendency	DOID:10923	sickle cell anemia	D005319	Fetal Hemoglobin	EFOID:0004576	sickle cell anemia	Sickle cell disease	rs11968814-A	Research Support, N.I.H., Extramural	G	NA
6	135382980	rs6904897	T	G	rs6904897	17767159	1.20E-06	NA	NA	NA	179 adults in upper and lower 5%	NOPOP(179)	ALL(179)	NOPOP(179)	ALL(179)	F-cell distribution	HPOID:0008346	Increased red cell sickling tendency	DOID:10923	sickle cell anemia	D005319	Fetal Hemoglobin	EFOID:0004576	sickle cell anemia	Sickle cell disease	NA	Research Support, Non-U.S. Gov't	G	NA
6	135382980	rs6904897	T	G	rs6904897	21326311	1.20E-06	NA	NA	NA	440 African ancestry individuals	African(440)	ALL(440)	AFR(440)	ALL(440)	F-cell distribution	HPOID:0008346	Increased red cell sickling tendency	DOID:10923	sickle cell anemia	D005319	Fetal Hemoglobin	EFOID:0004576	sickle cell anemia	Sickle cell disease	NA	Research Support, N.I.H., Extramural	G	NA
6	135419018	rs9399137	T	C	rs9399137	17767159	3.00E-36	NA	15.8	NA	179 adults in upper and lower 5%	NOPOP(179)	ALL(179)	NOPOP(179)	ALL(179)	F-cell distribution	HPOID:0008346	Increased red cell sickling tendency	DOID:10923	sickle cell anemia	D005319	Fetal Hemoglobin	EFOID:0004576	sickle cell anemia	Sickle cell disease	NA	Research Support, Non-U.S. Gov't	T	NA
6	135419018	rs9399137	T	C	rs9399137	21326311	2.50E-36	NA	NA	NA	440 African ancestry individuals	African(440)	ALL(440)	AFR(440)	ALL(440)	F-cell distribution	HPOID:0008346	Increased red cell sickling tendency	DOID:10923	sickle cell anemia	D005319	Fetal Hemoglobin	EFOID:0004576	sickle cell anemia	Sickle cell disease	NA	Research Support, N.I.H., Extramural	T	NA
6	135426573	rs4895441	A	G	rs4895441	21326311	1.60E-20	NA	NA	NA	440 African ancestry individuals	African(440)	ALL(440)	AFR(440)	ALL(440)	F-cell distribution	HPOID:0008346	Increased red cell sickling tendency	DOID:10923	sickle cell anemia	D005319	Fetal Hemoglobin	EFOID:0004576	sickle cell anemia	Sickle cell disease	NA	Research Support, N.I.H., Extramural	A	NA
6	135443212	rs1320963	A	G	rs1320963	17767159	4.10E-15	NA	NA	NA	179 adults in upper and lower 5%	NOPOP(179)	ALL(179)	NOPOP(179)	ALL(179)	F-cell distribution	HPOID:0008346	Increased red cell sickling tendency	DOID:10923	sickle cell anemia	D005319	Fetal Hemoglobin	EFOID:0004576	sickle cell anemia	Sickle cell disease	NA	Research Support, Non-U.S. Gov't	G	NA
6	135443212	rs1320963	A	G	rs1320963	21326311	4.10E-15	NA	NA	NA	440 African ancestry individuals	African(440)	ALL(440)	AFR(440)	ALL(440)	F-cell distribution	HPOID:0008346	Increased red cell sickling tendency	DOID:10923	sickle cell anemia	D005319	Fetal Hemoglobin	EFOID:0004576	sickle cell anemia	Sickle cell disease	NA	Research Support, N.I.H., Extramural	G	NA
6	148178358	rs3850229	G	A	rs3850229	21326311	1.06E-05	NA	NA	NA	440 African ancestry individuals	African(440)	ALL(440)	AFR(440)	ALL(440)	F-cell distribution	HPOID:0008346	Increased red cell sickling tendency	DOID:10923	sickle cell anemia	D005319	Fetal Hemoglobin	EFOID:0004576	sickle cell anemia	Sickle cell disease	NA	Research Support, N.I.H., Extramural	G	NA
6	155978097	rs9480179	C	T	rs9480179	20029952	9.71E-06	Sickle cell anemia severity	NA	NA	177 African American severe patients; 1088 African American mild patients	African American(1265)	ALL(1265)	AFR(1265)	ALL(1265)	Sickle cell anemia (severity)	HPOID:0008346	Increased red cell sickling tendency	DOID:10923	sickle cell anemia	NA	NA	NA	NA	Sickle cell disease	NA	Research Support, N.I.H., Extramural	C	NA
6	160384403	rs6934383	A	G	rs6934383	20029952	1.50E-05	Sickle cell anemia severity	NA	NA	177 African American severe patients; 1088 African American mild patients	African American(1265)	ALL(1265)	AFR(1265)	ALL(1265)	Sickle cell anemia (severity)	HPOID:0008346	Increased red cell sickling tendency	DOID:10923	sickle cell anemia	NA	NA	NA	NA	Sickle cell disease	NA	Research Support, N.I.H., Extramural	G	NA
7	22000425	rs6461625	G	A	rs6461625	20029952	2.70E-06	Sickle cell anemia severity	NA	NA	177 African American severe patients; 1088 African American mild patients	African American(1265)	ALL(1265)	AFR(1265)	ALL(1265)	Sickle cell anemia (severity)	HPOID:0008346	Increased red cell sickling tendency	DOID:10923	sickle cell anemia	NA	NA	NA	NA	Sickle cell disease	NA	Research Support, N.I.H., Extramural	G	NA
7	68701972	rs12667374	G	A	rs12667374	17767159	1.00E-05	NA	NA	NA	179 adults in upper and lower 5%	NOPOP(179)	ALL(179)	NOPOP(179)	ALL(179)	F-cell distribution	HPOID:0008346	Increased red cell sickling tendency	DOID:10923	sickle cell anemia	D005319	Fetal Hemoglobin	EFOID:0004576	sickle cell anemia	Sickle cell disease	NA	Research Support, Non-U.S. Gov't	G	NA
7	70471892	rs1949857	C	T	rs1949857	21326311	1.62E-05	NA	NA	NA	440 African ancestry individuals	African(440)	ALL(440)	AFR(440)	ALL(440)	F-cell distribution	HPOID:0008346	Increased red cell sickling tendency	DOID:10923	sickle cell anemia	D005319	Fetal Hemoglobin	EFOID:0004576	sickle cell anemia	Sickle cell disease	NA	Research Support, N.I.H., Extramural	T	NA
7	115082872	rs9641540	A	C	rs9641540	20029952	1.33E-05	Sickle cell anemia severity	NA	NA	177 African American severe patients; 1088 African American mild patients	African American(1265)	ALL(1265)	AFR(1265)	ALL(1265)	Sickle cell anemia (severity)	HPOID:0008346	Increased red cell sickling tendency	DOID:10923	sickle cell anemia	NA	NA	NA	NA	Sickle cell disease	NA	Research Support, N.I.H., Extramural	C	NA
7	138411425	rs3800569	C	T	rs3800569	21326311	6.00E-06	NA	1.2	[0.69-1.71] unit increase	440 African ancestry individuals	African(440)	ALL(440)	AFR(440)	ALL(440)	F-cell distribution	HPOID:0008346	Increased red cell sickling tendency	DOID:10923	sickle cell anemia	D005319	Fetal Hemoglobin	EFOID:0004576	sickle cell anemia	Sickle cell disease	rs3800569-C	Research Support, N.I.H., Extramural	A	ATP6V0A4
8	4676416	rs17071569	T	G	rs17071569	21326311	3.32E-05	NA	NA	NA	440 African ancestry individuals	African(440)	ALL(440)	AFR(440)	ALL(440)	F-cell distribution	HPOID:0008346	Increased red cell sickling tendency	DOID:10923	sickle cell anemia	D005319	Fetal Hemoglobin	EFOID:0004576	sickle cell anemia	Sickle cell disease	NA	Research Support, N.I.H., Extramural	T	CSMD1
8	19540122	rs11985450	C	T	rs11985450	21326311	4.75E-05	NA	NA	NA	440 African ancestry individuals	African(440)	ALL(440)	AFR(440)	ALL(440)	F-cell distribution	HPOID:0008346	Increased red cell sickling tendency	DOID:10923	sickle cell anemia	D005319	Fetal Hemoglobin	EFOID:0004576	sickle cell anemia	Sickle cell disease	NA	Research Support, N.I.H., Extramural	T	CSGALNACT1
8	95124056	rs4421324	A	G	rs4421324	20029952	2.37E-06	Sickle cell anemia severity	NA	NA	177 African American severe patients; 1088 African American mild patients	African American(1265)	ALL(1265)	AFR(1265)	ALL(1265)	Sickle cell anemia (severity)	HPOID:0008346	Increased red cell sickling tendency	DOID:10923	sickle cell anemia	NA	NA	NA	NA	Sickle cell disease	NA	Research Support, N.I.H., Extramural	A	NA
8	128435924	rs6470511	A	G	rs6470511	21326311	5.06E-05	NA	NA	NA	440 African ancestry individuals	African(440)	ALL(440)	AFR(440)	ALL(440)	F-cell distribution	HPOID:0008346	Increased red cell sickling tendency	DOID:10923	sickle cell anemia	D005319	Fetal Hemoglobin	EFOID:0004576	sickle cell anemia	Sickle cell disease	NA	Research Support, N.I.H., Extramural	A	NA
8	132441048	rs1430317	T	C	rs1430317	20029952	3.60E-06	Sickle cell anemia severity	NA	NA	177 African American severe patients; 1088 African American mild patients	African American(1265)	ALL(1265)	AFR(1265)	ALL(1265)	Sickle cell anemia (severity)	HPOID:0008346	Increased red cell sickling tendency	DOID:10923	sickle cell anemia	NA	NA	NA	NA	Sickle cell disease	NA	Research Support, N.I.H., Extramural	A	NA
9	3338749	rs10971465	A	G	rs10971465	20029952	3.44E-06	Sickle cell anemia severity	NA	NA	177 African American severe patients; 1088 African American mild patients	African American(1265)	ALL(1265)	AFR(1265)	ALL(1265)	Sickle cell anemia (severity)	HPOID:0008346	Increased red cell sickling tendency	DOID:10923	sickle cell anemia	NA	NA	NA	NA	Sickle cell disease	NA	Research Support, N.I.H., Extramural	A	RFX3
9	3344786	rs7036456	G	A	rs7036456	20029952	3.26E-07	Sickle cell anemia severity	NA	NA	177 African American severe patients; 1088 African American mild patients	African American(1265)	ALL(1265)	AFR(1265)	ALL(1265)	Sickle cell anemia (severity)	HPOID:0008346	Increased red cell sickling tendency	DOID:10923	sickle cell anemia	NA	NA	NA	NA	Sickle cell disease	NA	Research Support, N.I.H., Extramural	G	RFX3
9	7603506	rs3864785	G	C	rs3864785	22679008	0.000000048	NA	NA	NA	112 cases; 63 controls	NOPOP(175)	ALL(175)	NOPOP(175)	ALL(175)	Sickle cell anemia	HPOID:0008346	Increased red cell sickling tendency	DOID:10923	sickle cell anemia	NA	NA	NA	NA	Sickle cell disease	NA	Research Support, N.I.H., Extramural	C	NA
9	17899606	rs1977882	C	A,G,T	rs1977882	21326311	4.24E-05	NA	NA	NA	440 African ancestry individuals	African(440)	ALL(440)	AFR(440)	ALL(440)	F-cell distribution	HPOID:0008346	Increased red cell sickling tendency	DOID:10923	sickle cell anemia	D005319	Fetal Hemoglobin	EFOID:0004576	sickle cell anemia	Sickle cell disease	NA	Research Support, N.I.H., Extramural	C	NA
9	19712170	rs7869360	G	A	rs7869360	21326311	3.52E-05	NA	NA	NA	440 African ancestry individuals	African(440)	ALL(440)	AFR(440)	ALL(440)	F-cell distribution	HPOID:0008346	Increased red cell sickling tendency	DOID:10923	sickle cell anemia	D005319	Fetal Hemoglobin	EFOID:0004576	sickle cell anemia	Sickle cell disease	NA	Research Support, N.I.H., Extramural	G	SLC24A2
9	29336303	rs16914695	A	G	rs16914695	21326311	9.61E-06	NA	NA	NA	440 African ancestry individuals	African(440)	ALL(440)	AFR(440)	ALL(440)	F-cell distribution	HPOID:0008346	Increased red cell sickling tendency	DOID:10923	sickle cell anemia	D005319	Fetal Hemoglobin	EFOID:0004576	sickle cell anemia	Sickle cell disease	NA	Research Support, N.I.H., Extramural	A	NA
9	96138557	rs1931371	A	G	rs1931371	21326311	1.81E-05	NA	NA	NA	440 African ancestry individuals	African(440)	ALL(440)	AFR(440)	ALL(440)	F-cell distribution	HPOID:0008346	Increased red cell sickling tendency	DOID:10923	sickle cell anemia	D005319	Fetal Hemoglobin	EFOID:0004576	sickle cell anemia	Sickle cell disease	NA	Research Support, N.I.H., Extramural	A	NA
9	134836197	rs7032759	T	C	rs7032759	21326311	2.19E-05	NA	NA	NA	440 African ancestry individuals	African(440)	ALL(440)	AFR(440)	ALL(440)	F-cell distribution	HPOID:0008346	Increased red cell sickling tendency	DOID:10923	sickle cell anemia	D005319	Fetal Hemoglobin	EFOID:0004576	sickle cell anemia	Sickle cell disease	NA	Research Support, N.I.H., Extramural	C	MED27
10	7144255	rs2462692	T	A,C,G	rs2462692	20029952	2.33E-19	Sickle cell anemia severity	NA	NA	177 African American severe patients; 1088 African American mild patients	African American(1265)	ALL(1265)	AFR(1265)	ALL(1265)	Sickle cell anemia (severity)	HPOID:0008346	Increased red cell sickling tendency	DOID:10923	sickle cell anemia	NA	NA	NA	NA	Sickle cell disease	NA	Research Support, N.I.H., Extramural	C	NA
10	29938853	rs12412148	G	A	rs12412148	21326311	2.86E-05	NA	NA	NA	440 African ancestry individuals	African(440)	ALL(440)	AFR(440)	ALL(440)	F-cell distribution	HPOID:0008346	Increased red cell sickling tendency	DOID:10923	sickle cell anemia	D005319	Fetal Hemoglobin	EFOID:0004576	sickle cell anemia	Sickle cell disease	NA	Research Support, N.I.H., Extramural	G	SVIL
10	33583089	rs4934871	G	A	rs4934871	21326311	1.63E-05	NA	NA	NA	440 African ancestry individuals	African(440)	ALL(440)	AFR(440)	ALL(440)	F-cell distribution	HPOID:0008346	Increased red cell sickling tendency	DOID:10923	sickle cell anemia	D005319	Fetal Hemoglobin	EFOID:0004576	sickle cell anemia	Sickle cell disease	NA	Research Support, N.I.H., Extramural	G	NRP1
10	88637677	rs2125053	G	A	rs2125053	20029952	9.77E-06	Sickle cell anemia severity	NA	NA	177 African American severe patients; 1088 African American mild patients	African American(1265)	ALL(1265)	AFR(1265)	ALL(1265)	Sickle cell anemia (severity)	HPOID:0008346	Increased red cell sickling tendency	DOID:10923	sickle cell anemia	NA	NA	NA	NA	Sickle cell disease	NA	Research Support, N.I.H., Extramural	A	BMPR1A
11	4953462	rs840716	G	T	rs840716	21326311	9.30E-09	NA	NA	NA	440 African ancestry individuals	African(440)	ALL(440)	AFR(440)	ALL(440)	F-cell distribution	HPOID:0008346	Increased red cell sickling tendency	DOID:10923	sickle cell anemia	D005319	Fetal Hemoglobin	EFOID:0004576	sickle cell anemia	Sickle cell disease	NA	Research Support, N.I.H., Extramural	G	NA
11	5029703	rs2445284	C	T	rs2445284	23406172	1.00E-29	NA	0.82	[0.68-0.96] unit decrease	1,117 individuals	NOPOP(1117)	ALL(1117)	NOPOP(1117)	ALL(1117)	Sickle cell anemia (haemolysis)	HPOID:0008346	Increased red cell sickling tendency	DOID:10923	sickle cell anemia	NA	NA	sickle cell anemia	Sickle cell disease	rs2445284-G	Multicenter Study	Clinical Trial	Research Support, N.I.H., Extramural	Research Support, Non-U.S. Gov't
11	5214413	rs10837540	T	A	rs10837540	21326311	1.80E-07	NA	NA	NA	440 African ancestry individuals	African(440)	ALL(440)	AFR(440)	ALL(440)	F-cell distribution	HPOID:0008346	Increased red cell sickling tendency	DOID:10923	sickle cell anemia	D005319	Fetal Hemoglobin	EFOID:0004576	sickle cell anemia	Sickle cell disease	NA	Research Support, N.I.H., Extramural	A	NA
11	5222379	rs7937649	G	A	rs7937649	21326311	7.30E-08	NA	NA	NA	440 African ancestry individuals	African(440)	ALL(440)	AFR(440)	ALL(440)	F-cell distribution	HPOID:0008346	Increased red cell sickling tendency	DOID:10923	sickle cell anemia	D005319	Fetal Hemoglobin	EFOID:0004576	sickle cell anemia	Sickle cell disease	NA	Research Support, N.I.H., Extramural	A	NA
11	5260576	rs968856	T	C	rs968856	21326311	6.70E-07	NA	NA	NA	440 African ancestry individuals	African(440)	ALL(440)	AFR(440)	ALL(440)	F-cell distribution	HPOID:0008346	Increased red cell sickling tendency	DOID:10923	sickle cell anemia	D005319	Fetal Hemoglobin	EFOID:0004576	sickle cell anemia	Sickle cell disease	NA	Research Support, N.I.H., Extramural	A	NA
11	5276169	rs7482144	G	A	rs7482144	17767159	2.40E-38	NA	NA	NA	179 adults in upper and lower 5%	NOPOP(179)	ALL(179)	NOPOP(179)	ALL(179)	F-cell distribution	HPOID:0008346	Increased red cell sickling tendency	DOID:10923	sickle cell anemia	D005319	Fetal Hemoglobin	EFOID:0004576	sickle cell anemia	Sickle cell disease	NA	Research Support, Non-U.S. Gov't	G	LOC100653006
11	5276169	rs7482144	G	A	rs7482144	21326311	2.40E-38	NA	NA	NA	440 African ancestry individuals	African(440)	ALL(440)	AFR(440)	ALL(440)	F-cell distribution	HPOID:0008346	Increased red cell sickling tendency	DOID:10923	sickle cell anemia	D005319	Fetal Hemoglobin	EFOID:0004576	sickle cell anemia	Sickle cell disease	NA	Research Support, N.I.H., Extramural	G	LOC100653006
11	5306509	rs4910742	G	A	rs4910742	21326311	1.20E-21	NA	NA	NA	440 African ancestry individuals	African(440)	ALL(440)	AFR(440)	ALL(440)	F-cell distribution	HPOID:0008346	Increased red cell sickling tendency	DOID:10923	sickle cell anemia	D005319	Fetal Hemoglobin	EFOID:0004576	sickle cell anemia	Sickle cell disease	NA	Research Support, N.I.H., Extramural	A	NA
11	5373251	rs5006884	C	T	rs5006884	21326311	2.72E-08	NA	NA	NA	440 African ancestry individuals	African(440)	ALL(440)	AFR(440)	ALL(440)	F-cell distribution	HPOID:0008346	Increased red cell sickling tendency	DOID:10923	sickle cell anemia	D005319	Fetal Hemoglobin	EFOID:0004576	sickle cell anemia	Sickle cell disease	NA	Research Support, N.I.H., Extramural	C	OR51B6
11	5455929	rs1391619	G	A	rs1391619	21326311	1.10E-09	NA	NA	NA	440 African ancestry individuals	African(440)	ALL(440)	AFR(440)	ALL(440)	F-cell distribution	HPOID:0008346	Increased red cell sickling tendency	DOID:10923	sickle cell anemia	D005319	Fetal Hemoglobin	EFOID:0004576	sickle cell anemia	Sickle cell disease	NA	Research Support, N.I.H., Extramural	T	OR51B5
11	5471746	rs7948471	G	A	rs7948471	23406172	3.00E-10	NA	0.26	[0.18-0.34] unit decrease	1,117 individuals	NOPOP(1117)	ALL(1117)	NOPOP(1117)	ALL(1117)	Sickle cell anemia (haemolysis)	HPOID:0008346	Increased red cell sickling tendency	DOID:10923	sickle cell anemia	NA	NA	sickle cell anemia	Sickle cell disease	rs7948471-A	Multicenter Study	Clinical Trial	Research Support, N.I.H., Extramural	Research Support, Non-U.S. Gov't
11	44492899	rs357917	A	G	rs357917	20029952	1.30E-05	Sickle cell anemia severity	NA	NA	177 African American severe patients; 1088 African American mild patients	African American(1265)	ALL(1265)	AFR(1265)	ALL(1265)	Sickle cell anemia (severity)	HPOID:0008346	Increased red cell sickling tendency	DOID:10923	sickle cell anemia	NA	NA	NA	NA	Sickle cell disease	NA	Research Support, N.I.H., Extramural	T	NA
11	93299743	rs7124828	G	T	rs7124828	20029952	5.56E-09	Sickle cell anemia severity	NA	NA	177 African American severe patients; 1088 African American mild patients	African American(1265)	ALL(1265)	AFR(1265)	ALL(1265)	Sickle cell anemia (severity)	HPOID:0008346	Increased red cell sickling tendency	DOID:10923	sickle cell anemia	NA	NA	NA	NA	Sickle cell disease	NA	Research Support, N.I.H., Extramural	G	NA
11	124461274	rs7127399	G	A	rs7127399	20029952	2.24E-05	Sickle cell anemia severity	NA	NA	177 African American severe patients; 1088 African American mild patients	African American(1265)	ALL(1265)	AFR(1265)	ALL(1265)	Sickle cell anemia (severity)	HPOID:0008346	Increased red cell sickling tendency	DOID:10923	sickle cell anemia	NA	NA	NA	NA	Sickle cell disease	NA	Research Support, N.I.H., Extramural	A	NA
12	3556350	rs6489469	G	A	rs6489469	20029952	1.31E-05	Sickle cell anemia severity	NA	NA	177 African American severe patients; 1088 African American mild patients	African American(1265)	ALL(1265)	AFR(1265)	ALL(1265)	Sickle cell anemia (severity)	HPOID:0008346	Increased red cell sickling tendency	DOID:10923	sickle cell anemia	NA	NA	NA	NA	Sickle cell disease	NA	Research Support, N.I.H., Extramural	A	PRMT8
12	12052702	rs2954930	G	A	rs2954930	21326311	2.66E-05	NA	NA	NA	440 African ancestry individuals	African(440)	ALL(440)	AFR(440)	ALL(440)	F-cell distribution	HPOID:0008346	Increased red cell sickling tendency	DOID:10923	sickle cell anemia	D005319	Fetal Hemoglobin	EFOID:0004576	sickle cell anemia	Sickle cell disease	NA	Research Support, N.I.H., Extramural	A	NA
12	13120851	rs1486329	C	T	rs1486329	20029952	8.10E-07	Sickle cell anemia severity	NA	NA	177 African American severe patients; 1088 African American mild patients	African American(1265)	ALL(1265)	AFR(1265)	ALL(1265)	Sickle cell anemia (severity)	HPOID:0008346	Increased red cell sickling tendency	DOID:10923	sickle cell anemia	NA	NA	NA	NA	Sickle cell disease	NA	Research Support, N.I.H., Extramural	T	NA
12	27059422	rs1488051	T	C	rs1488051	21326311	2.39E-05	NA	NA	NA	440 African ancestry individuals	African(440)	ALL(440)	AFR(440)	ALL(440)	F-cell distribution	HPOID:0008346	Increased red cell sickling tendency	DOID:10923	sickle cell anemia	D005319	Fetal Hemoglobin	EFOID:0004576	sickle cell anemia	Sickle cell disease	NA	Research Support, N.I.H., Extramural	G	ASUN
12	115616315	rs16945105	C	T	rs16945105	21326311	1.79E-05	NA	NA	NA	440 African ancestry individuals	African(440)	ALL(440)	AFR(440)	ALL(440)	F-cell distribution	HPOID:0008346	Increased red cell sickling tendency	DOID:10923	sickle cell anemia	D005319	Fetal Hemoglobin	EFOID:0004576	sickle cell anemia	Sickle cell disease	NA	Research Support, N.I.H., Extramural	C	NA
12	131078425	rs7969337	G	A	rs7969337	21326311	2.74E-05	NA	NA	NA	440 African ancestry individuals	African(440)	ALL(440)	AFR(440)	ALL(440)	F-cell distribution	HPOID:0008346	Increased red cell sickling tendency	DOID:10923	sickle cell anemia	D005319	Fetal Hemoglobin	EFOID:0004576	sickle cell anemia	Sickle cell disease	NA	Research Support, N.I.H., Extramural	G	NA
12	131088522	rs2129663	T	G	rs2129663	21326311	7.53E-06	NA	NA	NA	440 African ancestry individuals	African(440)	ALL(440)	AFR(440)	ALL(440)	F-cell distribution	HPOID:0008346	Increased red cell sickling tendency	DOID:10923	sickle cell anemia	D005319	Fetal Hemoglobin	EFOID:0004576	sickle cell anemia	Sickle cell disease	NA	Research Support, N.I.H., Extramural	C	NA
13	22315063	rs596837	C	T	rs596837	20029952	1.80E-05	Sickle cell anemia severity	NA	NA	177 African American severe patients; 1088 African American mild patients	African American(1265)	ALL(1265)	AFR(1265)	ALL(1265)	Sickle cell anemia (severity)	HPOID:0008346	Increased red cell sickling tendency	DOID:10923	sickle cell anemia	NA	NA	NA	NA	Sickle cell disease	NA	Research Support, N.I.H., Extramural	C	NA
13	90259291	rs2655738	A	G	rs2655738	20029952	6.91E-05	Sickle cell anemia severity	NA	NA	177 African American severe patients; 1088 African American mild patients	African American(1265)	ALL(1265)	AFR(1265)	ALL(1265)	Sickle cell anemia (severity)	HPOID:0008346	Increased red cell sickling tendency	DOID:10923	sickle cell anemia	NA	NA	NA	NA	Sickle cell disease	NA	Research Support, N.I.H., Extramural	G	NA
13	90694767	rs2637385	A	C	rs2637385	20029952	5.39E-06	Sickle cell anemia severity	NA	NA	177 African American severe patients; 1088 African American mild patients	African American(1265)	ALL(1265)	AFR(1265)	ALL(1265)	Sickle cell anemia (severity)	HPOID:0008346	Increased red cell sickling tendency	DOID:10923	sickle cell anemia	NA	NA	NA	NA	Sickle cell disease	NA	Research Support, N.I.H., Extramural	G	NA
14	20903778	rs8017682	G	A	rs8017682	21326311	3.72E-05	NA	NA	NA	440 African ancestry individuals	African(440)	ALL(440)	AFR(440)	ALL(440)	F-cell distribution	HPOID:0008346	Increased red cell sickling tendency	DOID:10923	sickle cell anemia	D005319	Fetal Hemoglobin	EFOID:0004576	sickle cell anemia	Sickle cell disease	NA	Research Support, N.I.H., Extramural	G	KLHL33
14	68973546	rs757369	A	G	rs757369	21326311	2.83E-05	NA	NA	NA	440 African ancestry individuals	African(440)	ALL(440)	AFR(440)	ALL(440)	F-cell distribution	HPOID:0008346	Increased red cell sickling tendency	DOID:10923	sickle cell anemia	D005319	Fetal Hemoglobin	EFOID:0004576	sickle cell anemia	Sickle cell disease	NA	Research Support, N.I.H., Extramural	G	RAD51B
14	96556268	rs3742480	G	T	rs3742480	21326311	4.92E-05	NA	NA	NA	440 African ancestry individuals	African(440)	ALL(440)	AFR(440)	ALL(440)	F-cell distribution	HPOID:0008346	Increased red cell sickling tendency	DOID:10923	sickle cell anemia	D005319	Fetal Hemoglobin	EFOID:0004576	sickle cell anemia	Sickle cell disease	NA	Research Support, N.I.H., Extramural	C	C14orf132
15	68058903	rs11071959	A	G	rs11071959	21326311	9.89E-06	NA	NA	NA	440 African ancestry individuals	African(440)	ALL(440)	AFR(440)	ALL(440)	F-cell distribution	HPOID:0008346	Increased red cell sickling tendency	DOID:10923	sickle cell anemia	D005319	Fetal Hemoglobin	EFOID:0004576	sickle cell anemia	Sickle cell disease	NA	Research Support, N.I.H., Extramural	A	MAP2K5
15	78806023	rs8034191	T	C	rs8034191	21326311	3.68E-06	NA	NA	NA	440 African ancestry individuals	African(440)	ALL(440)	AFR(440)	ALL(440)	F-cell distribution	HPOID:0008346	Increased red cell sickling tendency	DOID:10923	sickle cell anemia	D005319	Fetal Hemoglobin	EFOID:0004576	sickle cell anemia	Sickle cell disease	NA	Research Support, N.I.H., Extramural	T	AGPHD1
15	89355911	rs12439075	C	T	rs12439075	20029952	6.70E-05	Sickle cell anemia severity	NA	NA	177 African American severe patients; 1088 African American mild patients	African American(1265)	ALL(1265)	AFR(1265)	ALL(1265)	Sickle cell anemia (severity)	HPOID:0008346	Increased red cell sickling tendency	DOID:10923	sickle cell anemia	NA	NA	NA	NA	Sickle cell disease	NA	Research Support, N.I.H., Extramural	T	ACAN
16	184390	rs7203560	T	G	rs7203560	23406172	2.00E-09	NA	0.44	[0.30-0.58] unit decrease	1,117 individuals	NOPOP(1117)	ALL(1117)	NOPOP(1117)	ALL(1117)	Sickle cell anemia (haemolysis)	HPOID:0008346	Increased red cell sickling tendency	DOID:10923	sickle cell anemia	NA	NA	sickle cell anemia	Sickle cell disease	rs7203560-C	Multicenter Study	Clinical Trial	Research Support, N.I.H., Extramural	Research Support, Non-U.S. Gov't
16	78688144	rs2113120	T	C	rs2113120	21326311	2.55E-05	NA	NA	NA	440 African ancestry individuals	African(440)	ALL(440)	AFR(440)	ALL(440)	F-cell distribution	HPOID:0008346	Increased red cell sickling tendency	DOID:10923	sickle cell anemia	D005319	Fetal Hemoglobin	EFOID:0004576	sickle cell anemia	Sickle cell disease	NA	Research Support, N.I.H., Extramural	G	WWOX
17	9564861	rs274907	T	G	rs274907	21326311	2.42E-05	NA	NA	NA	440 African ancestry individuals	African(440)	ALL(440)	AFR(440)	ALL(440)	F-cell distribution	HPOID:0008346	Increased red cell sickling tendency	DOID:10923	sickle cell anemia	D005319	Fetal Hemoglobin	EFOID:0004576	sickle cell anemia	Sickle cell disease	NA	Research Support, N.I.H., Extramural	C	USP43
17	9696883	rs4791866	C	T	rs4791866	21326311	6.24E-06	NA	NA	NA	440 African ancestry individuals	African(440)	ALL(440)	AFR(440)	ALL(440)	F-cell distribution	HPOID:0008346	Increased red cell sickling tendency	DOID:10923	sickle cell anemia	D005319	Fetal Hemoglobin	EFOID:0004576	sickle cell anemia	Sickle cell disease	NA	Research Support, N.I.H., Extramural	T	NA
17	9698342	rs12103880	G	A	rs12103880	21326311	3.41E-08	NA	NA	NA	440 African ancestry individuals	African(440)	ALL(440)	AFR(440)	ALL(440)	F-cell distribution	HPOID:0008346	Increased red cell sickling tendency	DOID:10923	sickle cell anemia	D005319	Fetal Hemoglobin	EFOID:0004576	sickle cell anemia	Sickle cell disease	NA	Research Support, N.I.H., Extramural	G	NA
17	71898105	rs8065308	C	T	rs8065308	20029952	1.30E-06	Sickle cell anemia severity	NA	NA	177 African American severe patients; 1088 African American mild patients	African American(1265)	ALL(1265)	AFR(1265)	ALL(1265)	Sickle cell anemia (severity)	HPOID:0008346	Increased red cell sickling tendency	DOID:10923	sickle cell anemia	NA	NA	NA	NA	Sickle cell disease	NA	Research Support, N.I.H., Extramural	T	NA
18	35515421	rs12969251	A	G	rs12969251	20029952	3.66E-08	Sickle cell anemia severity	NA	NA	177 African American severe patients; 1088 African American mild patients	African American(1265)	ALL(1265)	AFR(1265)	ALL(1265)	Sickle cell anemia (severity)	HPOID:0008346	Increased red cell sickling tendency	DOID:10923	sickle cell anemia	NA	NA	NA	NA	Sickle cell disease	NA	Research Support, N.I.H., Extramural	A	NA
18	47725047	rs1397677	C	T	rs1397677	21326311	3.15E-05	NA	NA	NA	440 African ancestry individuals	African(440)	ALL(440)	AFR(440)	ALL(440)	F-cell distribution	HPOID:0008346	Increased red cell sickling tendency	DOID:10923	sickle cell anemia	D005319	Fetal Hemoglobin	EFOID:0004576	sickle cell anemia	Sickle cell disease	NA	Research Support, N.I.H., Extramural	C	NA
18	47835784	rs9304395	G	T	rs9304395	21326311	2.04E-05	NA	NA	NA	440 African ancestry individuals	African(440)	ALL(440)	AFR(440)	ALL(440)	F-cell distribution	HPOID:0008346	Increased red cell sickling tendency	DOID:10923	sickle cell anemia	D005319	Fetal Hemoglobin	EFOID:0004576	sickle cell anemia	Sickle cell disease	NA	Research Support, N.I.H., Extramural	T	NA
18	51184594	rs1442080	G	A	rs1442080	21326311	2.86E-05	NA	NA	NA	440 African ancestry individuals	African(440)	ALL(440)	AFR(440)	ALL(440)	F-cell distribution	HPOID:0008346	Increased red cell sickling tendency	DOID:10923	sickle cell anemia	D005319	Fetal Hemoglobin	EFOID:0004576	sickle cell anemia	Sickle cell disease	NA	Research Support, N.I.H., Extramural	T	NA
18	60287284	rs10439027	T	C	rs10439027	21326311	2.40E-05	NA	NA	NA	440 African ancestry individuals	African(440)	ALL(440)	AFR(440)	ALL(440)	F-cell distribution	HPOID:0008346	Increased red cell sickling tendency	DOID:10923	sickle cell anemia	D005319	Fetal Hemoglobin	EFOID:0004576	sickle cell anemia	Sickle cell disease	NA	Research Support, N.I.H., Extramural	T	NA
18	65429532	rs11874977	A	G	rs11874977	21326311	5.32E-05	NA	NA	NA	440 African ancestry individuals	African(440)	ALL(440)	AFR(440)	ALL(440)	F-cell distribution	HPOID:0008346	Increased red cell sickling tendency	DOID:10923	sickle cell anemia	D005319	Fetal Hemoglobin	EFOID:0004576	sickle cell anemia	Sickle cell disease	NA	Research Support, N.I.H., Extramural	A	LOC643542
18	75333250	rs1521475	C	T	rs1521475	20029952	6.44E-06	Sickle cell anemia severity	NA	NA	177 African American severe patients; 1088 African American mild patients	African American(1265)	ALL(1265)	AFR(1265)	ALL(1265)	Sickle cell anemia (severity)	HPOID:0008346	Increased red cell sickling tendency	DOID:10923	sickle cell anemia	NA	NA	NA	NA	Sickle cell disease	NA	Research Support, N.I.H., Extramural	A	NA
19	22438069	rs283147	A	C	rs283147	21326311	3.68E-05	NA	NA	NA	440 African ancestry individuals	African(440)	ALL(440)	AFR(440)	ALL(440)	F-cell distribution	HPOID:0008346	Increased red cell sickling tendency	DOID:10923	sickle cell anemia	D005319	Fetal Hemoglobin	EFOID:0004576	sickle cell anemia	Sickle cell disease	NA	Research Support, N.I.H., Extramural	A	NA
19	38807184	rs3843754	G	A	rs3843754	20029952	1.82E-05	Sickle cell anemia severity	NA	NA	177 African American severe patients; 1088 African American mild patients	African American(1265)	ALL(1265)	AFR(1265)	ALL(1265)	Sickle cell anemia (severity)	HPOID:0008346	Increased red cell sickling tendency	DOID:10923	sickle cell anemia	NA	NA	NA	NA	Sickle cell disease	NA	Research Support, N.I.H., Extramural	A	NA
19	38882781	rs12609878	T	G	rs12609878	20029952	1.60E-05	Sickle cell anemia severity	NA	NA	177 African American severe patients; 1088 African American mild patients	African American(1265)	ALL(1265)	AFR(1265)	ALL(1265)	Sickle cell anemia (severity)	HPOID:0008346	Increased red cell sickling tendency	DOID:10923	sickle cell anemia	NA	NA	NA	NA	Sickle cell disease	NA	Research Support, N.I.H., Extramural	G	SPRED3
20	23489678	rs3004119	C	T	rs3004119	20029952	1.61E-06	Sickle cell anemia severity	NA	NA	177 African American severe patients; 1088 African American mild patients	African American(1265)	ALL(1265)	AFR(1265)	ALL(1265)	Sickle cell anemia (severity)	HPOID:0008346	Increased red cell sickling tendency	DOID:10923	sickle cell anemia	NA	NA	NA	NA	Sickle cell disease	NA	Research Support, N.I.H., Extramural	T	NA
20	44072196	rs2745061	C	T	rs2745061	20029952	1.49E-09	Sickle cell anemia severity	NA	NA	177 African American severe patients; 1088 African American mild patients	African American(1265)	ALL(1265)	AFR(1265)	ALL(1265)	Sickle cell anemia (severity)	HPOID:0008346	Increased red cell sickling tendency	DOID:10923	sickle cell anemia	NA	NA	NA	NA	Sickle cell disease	NA	Research Support, N.I.H., Extramural	C	NA
20	58544820	rs723680	G	A	rs723680	20029952	4.60E-06	Sickle cell anemia severity	NA	NA	177 African American severe patients; 1088 African American mild patients	African American(1265)	ALL(1265)	AFR(1265)	ALL(1265)	Sickle cell anemia (severity)	HPOID:0008346	Increased red cell sickling tendency	DOID:10923	sickle cell anemia	NA	NA	NA	NA	Sickle cell disease	NA	Research Support, N.I.H., Extramural	C	CDH26
21	33002145	rs1008270	C	A	rs1008270	20029952	3.62E-06	Sickle cell anemia severity	NA	NA	177 African American severe patients; 1088 African American mild patients	African American(1265)	ALL(1265)	AFR(1265)	ALL(1265)	Sickle cell anemia (severity)	HPOID:0008346	Increased red cell sickling tendency	DOID:10923	sickle cell anemia	NA	NA	NA	NA	Sickle cell disease	NA	Research Support, N.I.H., Extramural	A	NA
22	50999182	rs140518	C	T	rs140518	21326311	1.30E-05	NA	NA	NA	440 African ancestry individuals	African(440)	ALL(440)	AFR(440)	ALL(440)	F-cell distribution	HPOID:0008346	Increased red cell sickling tendency	DOID:10923	sickle cell anemia	D005319	Fetal Hemoglobin	EFOID:0004576	sickle cell anemia	Sickle cell disease	NA	Research Support, N.I.H., Extramural	A	SYCE3
X	5972382	rs1882411	C	T	rs1882411	21326311	1.88E-05	NA	NA	NA	440 African ancestry individuals	African(440)	ALL(440)	AFR(440)	ALL(440)	F-cell distribution	HPOID:0008346	Increased red cell sickling tendency	DOID:10923	sickle cell anemia	D005319	Fetal Hemoglobin	EFOID:0004576	sickle cell anemia	Sickle cell disease	NA	Research Support, N.I.H., Extramural	C	NLGN4X
X	6003778	rs5915642	T	C	rs5915642	21326311	1.13E-05	NA	NA	NA	440 African ancestry individuals	African(440)	ALL(440)	AFR(440)	ALL(440)	F-cell distribution	HPOID:0008346	Increased red cell sickling tendency	DOID:10923	sickle cell anemia	D005319	Fetal Hemoglobin	EFOID:0004576	sickle cell anemia	Sickle cell disease	NA	Research Support, N.I.H., Extramural	T	NLGN4X
X	6009208	rs6639594	C	T	rs6639594	21326311	7.78E-06	NA	NA	NA	440 African ancestry individuals	African(440)	ALL(440)	AFR(440)	ALL(440)	F-cell distribution	HPOID:0008346	Increased red cell sickling tendency	DOID:10923	sickle cell anemia	D005319	Fetal Hemoglobin	EFOID:0004576	sickle cell anemia	Sickle cell disease	NA	Research Support, N.I.H., Extramural	T	NLGN4X
X	22160992	rs12559632	G	A	rs12559632	21326311	3.00E-06	NA	1.16	[0.69-1.63] unit decrease	440 African ancestry individuals	African(440)	ALL(440)	AFR(440)	ALL(440)	F-cell distribution	HPOID:0008346	Increased red cell sickling tendency	DOID:10923	sickle cell anemia	D005319	Fetal Hemoglobin	EFOID:0004576	sickle cell anemia	Sickle cell disease	rs12559632-A	Research Support, N.I.H., Extramural	G	PHEX
X	22997533	rs5926195	A	G	rs5926195	21326311	2.44E-05	NA	NA	NA	440 African ancestry individuals	African(440)	ALL(440)	AFR(440)	ALL(440)	F-cell distribution	HPOID:0008346	Increased red cell sickling tendency	DOID:10923	sickle cell anemia	D005319	Fetal Hemoglobin	EFOID:0004576	sickle cell anemia	Sickle cell disease	NA	Research Support, N.I.H., Extramural	A	NA
X	25735888	rs1025952	C	T	rs1025952	21326311	6.00E-06	NA	NA	NA	440 African ancestry individuals	African(440)	ALL(440)	AFR(440)	ALL(440)	F-cell distribution	HPOID:0008346	Increased red cell sickling tendency	DOID:10923	sickle cell anemia	D005319	Fetal Hemoglobin	EFOID:0004576	sickle cell anemia	Sickle cell disease	NA	Research Support, N.I.H., Extramural	C	NA
X	25736480	rs6630120	A	G	rs6630120	21326311	1.48E-05	NA	NA	NA	440 African ancestry individuals	African(440)	ALL(440)	AFR(440)	ALL(440)	F-cell distribution	HPOID:0008346	Increased red cell sickling tendency	DOID:10923	sickle cell anemia	D005319	Fetal Hemoglobin	EFOID:0004576	sickle cell anemia	Sickle cell disease	NA	Research Support, N.I.H., Extramural	A	NA

Mapped by lexical matching(Total Items:0)
(Waiting for update.)

Mapped by homologous gene(Total Items:0)
(Waiting for update.)

Chemical(Total Drugs:8)
CUI	ChemicalName	ChemicalID	CasRN	DiseaseName	DiseaseID	DirectEvidence	PubMedIDs
C0002895	aspartame	D001218	22839-47-0	anemia, sickle cell	MESH:D000755	therapeutic	11372003
C0002895	baclofen	D001418	1134-47-0	anemia, sickle cell	MESH:D000755	therapeutic	18593679
C0002895	deferasirox	C415250	-	anemia, sickle cell	MESH:D000755	therapeutic	17233848
C0002895	folic acid	D005492	59-30-3	anemia, sickle cell	MESH:D000755	therapeutic	18593679
C0002895	hydromorphone	D004091	466-99-9	anemia, sickle cell	MESH:D000755	therapeutic	1373356
C0002895	hydroxyurea	D006918	127-07-1	anemia, sickle cell	MESH:D000755	therapeutic	14965870
C0002895	oxycodone	D010098	76-42-6	anemia, sickle cell	MESH:D000755	therapeutic	18593679
C0002895	paclitaxel	D017239	-	anemia, sickle cell	MESH:D000755	marker/mechanism	18593679

FDA approved drug and dosage information(Total Drugs:0)
(Waiting for update.)

FDA labeling changes(Total Drugs:0)
(Waiting for update.)