All Snps(Total Genotypes:143) |
|---|
| snpId |
pubmedId |
geneId |
geneSymbol |
diseaseId |
sourceId |
sentence |
score |
Year |
geneSymbol_dbSNP |
CHROMOSOME |
POS |
REF |
ALT |
| rs1059702 | 17785851 | 3654 | IRAK1 | umls:C0036690 | BeFree | We previously described that a commonly occurring IRAK-1 variant haplotype, containing amino acid changes from serine to phenylalanine at position 196 and from leucine to serine at position 532, is associated with increased activation of NF-kappaB in LPS-stimulated neutrophils from patients with sepsis-induced acute lung injury and also higher mortality and more severe clinical outcomes in such patients. | 0.001357209 | 2007 | IRAK1 | X | 154018741 | A | G |
| rs1059702 | 17785851 | 3654 | IRAK1 | umls:C0243026 | BeFree | We previously described that a commonly occurring IRAK-1 variant haplotype, containing amino acid changes from serine to phenylalanine at position 196 and from leucine to serine at position 532, is associated with increased activation of NF-kappaB in LPS-stimulated neutrophils from patients with sepsis-induced acute lung injury and also higher mortality and more severe clinical outcomes in such patients. | 0.006091273 | 2007 | IRAK1 | X | 154018741 | A | G |
| rs1059703 | 17785851 | 3654 | IRAK1 | umls:C0036690 | BeFree | We previously described that a commonly occurring IRAK-1 variant haplotype, containing amino acid changes from serine to phenylalanine at position 196 and from leucine to serine at position 532, is associated with increased activation of NF-kappaB in LPS-stimulated neutrophils from patients with sepsis-induced acute lung injury and also higher mortality and more severe clinical outcomes in such patients. | 0.001357209 | 2007 | IRAK1 | X | 154013378 | G | A |
| rs1059703 | 17785851 | 3654 | IRAK1 | umls:C0243026 | BeFree | We previously described that a commonly occurring IRAK-1 variant haplotype, containing amino acid changes from serine to phenylalanine at position 196 and from leucine to serine at position 532, is associated with increased activation of NF-kappaB in LPS-stimulated neutrophils from patients with sepsis-induced acute lung injury and also higher mortality and more severe clinical outcomes in such patients. | 0.006091273 | 2007 | IRAK1 | X | 154013378 | G | A |
| rs1061170 | 20351616 | 3075 | CFH | umls:C0243026 | BeFree | Homozygosity for the complement factor H Y402H polymorphism, which is thought to reduce complement inhibition, was associated with less frequent SIRS/sepsis (the adjusted odds ratio for the homozygous variant complement factor H Y402H [CC] carriers was 0.3, 95% confidence interval, 0.1-0.7, p = .005). | 0.081085767 | 2010 | CFH | 1 | 196690107 | C | T |
| rs1061170 | 20351616 | 3075 | CFH | umls:C0036690 | BeFree | Homozygosity for the complement factor H Y402H polymorphism, which is thought to reduce complement inhibition, was associated with less frequent SIRS/sepsis (the adjusted odds ratio for the homozygous variant complement factor H Y402H [CC] carriers was 0.3, 95% confidence interval, 0.1-0.7, p = .005). | 0.001085767 | 2010 | CFH | 1 | 196690107 | C | T |
| rs1143643 | 25000179 | 3553 | IL1B | umls:C0036690 | BeFree | Genotypes CT and TT of rs1143643 (the IL1β gene) and genotype GG of rs2664349GG (the MMP-16 gene) were associated with a significantly increased overall risk of developing sepsis (p = 0.03, p = 0.05 and p = 0.03), whereas genotypes AG of rs4358188 (the BPI gene) and CT of rs1799946 (the DEFβ1 gene) were associated with a significantly reduced risk of developing sepsis (p = 0.05 for both). | 0.003528744 | 2014 | IL1B | 2 | 112830725 | C | T |
| rs1143643 | 25000179 | 4325 | MMP16 | umls:C0036690 | BeFree | Genotypes CT and TT of rs1143643 (the IL1β gene) and genotype GG of rs2664349GG (the MMP-16 gene) were associated with a significantly increased overall risk of developing sepsis (p = 0.03, p = 0.05 and p = 0.03), whereas genotypes AG of rs4358188 (the BPI gene) and CT of rs1799946 (the DEFβ1 gene) were associated with a significantly reduced risk of developing sepsis (p = 0.05 for both). | 0.000271442 | 2014 | IL1B | 2 | 112830725 | C | T |
| rs1143643 | 25000179 | 671 | BPI | umls:C0036690 | BeFree | Genotypes CT and TT of rs1143643 (the IL1β gene) and genotype GG of rs2664349GG (the MMP-16 gene) were associated with a significantly increased overall risk of developing sepsis (p = 0.03, p = 0.05 and p = 0.03), whereas genotypes AG of rs4358188 (the BPI gene) and CT of rs1799946 (the DEFβ1 gene) were associated with a significantly reduced risk of developing sepsis (p = 0.05 for both). | 0.000814326 | 2014 | IL1B | 2 | 112830725 | C | T |
| rs1143643 | 25000179 | 3553 | IL1B | umls:C0243026 | BeFree | Genotypes CT and TT of rs1143643 (the IL1β gene) and genotype GG of rs2664349GG (the MMP-16 gene) were associated with a significantly increased overall risk of developing sepsis (p = 0.03, p = 0.05 and p = 0.03), whereas genotypes AG of rs4358188 (the BPI gene) and CT of rs1799946 (the DEFβ1 gene) were associated with a significantly reduced risk of developing sepsis (p = 0.05 for both). | 0.102822318 | 2014 | IL1B | 2 | 112830725 | C | T |
| rs1143643 | 25000179 | 671 | BPI | umls:C0243026 | BeFree | Genotypes CT and TT of rs1143643 (the IL1β gene) and genotype GG of rs2664349GG (the MMP-16 gene) were associated with a significantly increased overall risk of developing sepsis (p = 0.03, p = 0.05 and p = 0.03), whereas genotypes AG of rs4358188 (the BPI gene) and CT of rs1799946 (the DEFβ1 gene) were associated with a significantly reduced risk of developing sepsis (p = 0.05 for both). | 0.005819831 | 2014 | IL1B | 2 | 112830725 | C | T |
| rs1143643 | 25000179 | 4325 | MMP16 | umls:C0243026 | BeFree | Genotypes CT and TT of rs1143643 (the IL1β gene) and genotype GG of rs2664349GG (the MMP-16 gene) were associated with a significantly increased overall risk of developing sepsis (p = 0.03, p = 0.05 and p = 0.03), whereas genotypes AG of rs4358188 (the BPI gene) and CT of rs1799946 (the DEFβ1 gene) were associated with a significantly reduced risk of developing sepsis (p = 0.05 for both). | 0.002638474 | 2014 | IL1B | 2 | 112830725 | C | T |
| rs11465996 | 22266968 | 23643 | LY96 | umls:C0243026 | BeFree | Among the three htSNPs of the entire MD-2 gene, only the rs11465996 might be used as relevant risk estimate for the development of sepsis and MOD syndrome in patients with major trauma. | 0.003267234 | 2012 | LY96 | 8 | 73989727 | C | G |
| rs11465996 | 22266968 | 23643 | LY96 | umls:C0036690 | BeFree | Among the three htSNPs of the entire MD-2 gene, only the rs11465996 might be used as relevant risk estimate for the development of sepsis and MOD syndrome in patients with major trauma. | 0.000542884 | 2012 | LY96 | 8 | 73989727 | C | G |
| rs11536889 | 24950711 | 7099 | TLR4 | umls:C0243026 | BeFree | The regulatory toll-like receptor 4 genetic polymorphism rs11536889 is associated with renal, coagulation and hepatic organ failure in sepsis patients. | 0.243539115 | 2014 | TLR4 | 9 | 117715853 | G | C |
| rs11536889 | 24950711 | 7099 | TLR4 | umls:C0036690 | BeFree | The regulatory toll-like receptor 4 genetic polymorphism rs11536889 is associated with renal, coagulation and hepatic organ failure in sepsis patients. | 0.009771907 | 2014 | TLR4 | 9 | 117715853 | G | C |
| rs11568821 | 24463978 | 5133 | PDCD1 | umls:C0243026 | BeFree | Ninety-day survival rate of patients with sepsis relates to programmed cell death 1 genetic polymorphism rs11568821. | 0.000542884 | 2014 | PDCD1;LOC105373977 | 2 | 241851760 | C | T,G |
| rs11568821 | 24463978 | 5133 | PDCD1 | umls:C0036690 | BeFree | Ninety-day survival rate of patients with sepsis relates to programmed cell death 1 genetic polymorphism rs11568821. | 0.000542884 | 2014 | PDCD1;LOC105373977 | 2 | 241851760 | C | T,G |
| rs121917864 | 18249133 | 7097 | TLR2 | umls:C0243026 | BeFree | Single nucleotide polymorphisms (SNPs) Arg753Gln and Arg677Trp affect TLR2 responsiveness and may contribute to the course of sepsis, which is associated with substantial morbidity and mortality during intensive care treatment. | 0.099902471 | 2008 | TLR2 | 4 | 153704936 | C | T |
| rs121917864 | 18249133 | 7097 | TLR2 | umls:C0036690 | BeFree | Single nucleotide polymorphisms (SNPs) Arg753Gln and Arg677Trp affect TLR2 responsiveness and may contribute to the course of sepsis, which is associated with substantial morbidity and mortality during intensive care treatment. | 0.005428837 | 2008 | TLR2 | 4 | 153704936 | C | T |
| rs12652255 | 22310353 | 4488 | MSX2 | umls:C0243026 | GAD | [Beyond single-marker analyses: mining whole genome scans for insights into treatment responses in severe sepsis.] | 0.002367032 | 2013 | NA | 5 | 175334092 | C | A |
| rs13273073 | 22310353 | 137814 | NKX2-6 | umls:C0243026 | GAD | [Beyond single-marker analyses: mining whole genome scans for insights into treatment responses in severe sepsis.] | 0.002367032 | 2013 | LOC101929258 | 8 | 23726713 | G | T |
| rs144672509 | 22798017 | 54210 | TREM1 | umls:C0243026 | BeFree | Of the three tested TREM-1 SNPs (rs144672509, rs2234237, and rs2234246), only rs2234237 (Ser25Thr) was significantly associated with sepsis prognosis in three inheritance models (p < 0.05). | 0.003257302 | 2012 | TREM1 | 6 | 41282512 | G | A |
| rs144672509 | 22798017 | 54210 | TREM1 | umls:C0036690 | BeFree | Of the three tested TREM-1 SNPs (rs144672509, rs2234237, and rs2234246), only rs2234237 (Ser25Thr) was significantly associated with sepsis prognosis in three inheritance models (p < 0.05). | 0.003257302 | 2012 | TREM1 | 6 | 41282512 | G | A |
| rs1799946 | 25000179 | 4325 | MMP16 | umls:C0036690 | BeFree | Genotypes CT and TT of rs1143643 (the IL1β gene) and genotype GG of rs2664349GG (the MMP-16 gene) were associated with a significantly increased overall risk of developing sepsis (p = 0.03, p = 0.05 and p = 0.03), whereas genotypes AG of rs4358188 (the BPI gene) and CT of rs1799946 (the DEFβ1 gene) were associated with a significantly reduced risk of developing sepsis (p = 0.05 for both). | 0.000271442 | 2014 | DEFB1 | 8 | 6877909 | C | T |
| rs1799946 | 25000179 | 4325 | MMP16 | umls:C0243026 | BeFree | Genotypes CT and TT of rs1143643 (the IL1β gene) and genotype GG of rs2664349GG (the MMP-16 gene) were associated with a significantly increased overall risk of developing sepsis (p = 0.03, p = 0.05 and p = 0.03), whereas genotypes AG of rs4358188 (the BPI gene) and CT of rs1799946 (the DEFβ1 gene) were associated with a significantly reduced risk of developing sepsis (p = 0.05 for both). | 0.002638474 | 2014 | DEFB1 | 8 | 6877909 | C | T |
| rs1799946 | 25000179 | 3553 | IL1B | umls:C0243026 | BeFree | Genotypes CT and TT of rs1143643 (the IL1β gene) and genotype GG of rs2664349GG (the MMP-16 gene) were associated with a significantly increased overall risk of developing sepsis (p = 0.03, p = 0.05 and p = 0.03), whereas genotypes AG of rs4358188 (the BPI gene) and CT of rs1799946 (the DEFβ1 gene) were associated with a significantly reduced risk of developing sepsis (p = 0.05 for both). | 0.102822318 | 2014 | DEFB1 | 8 | 6877909 | C | T |
| rs1799946 | 25000179 | 3553 | IL1B | umls:C0036690 | BeFree | Genotypes CT and TT of rs1143643 (the IL1β gene) and genotype GG of rs2664349GG (the MMP-16 gene) were associated with a significantly increased overall risk of developing sepsis (p = 0.03, p = 0.05 and p = 0.03), whereas genotypes AG of rs4358188 (the BPI gene) and CT of rs1799946 (the DEFβ1 gene) were associated with a significantly reduced risk of developing sepsis (p = 0.05 for both). | 0.003528744 | 2014 | DEFB1 | 8 | 6877909 | C | T |
| rs1799946 | 25000179 | 671 | BPI | umls:C0036690 | BeFree | Genotypes CT and TT of rs1143643 (the IL1β gene) and genotype GG of rs2664349GG (the MMP-16 gene) were associated with a significantly increased overall risk of developing sepsis (p = 0.03, p = 0.05 and p = 0.03), whereas genotypes AG of rs4358188 (the BPI gene) and CT of rs1799946 (the DEFβ1 gene) were associated with a significantly reduced risk of developing sepsis (p = 0.05 for both). | 0.000814326 | 2014 | DEFB1 | 8 | 6877909 | C | T |
| rs1799946 | 25000179 | 671 | BPI | umls:C0243026 | BeFree | Genotypes CT and TT of rs1143643 (the IL1β gene) and genotype GG of rs2664349GG (the MMP-16 gene) were associated with a significantly increased overall risk of developing sepsis (p = 0.03, p = 0.05 and p = 0.03), whereas genotypes AG of rs4358188 (the BPI gene) and CT of rs1799946 (the DEFβ1 gene) were associated with a significantly reduced risk of developing sepsis (p = 0.05 for both). | 0.005819831 | 2014 | DEFB1 | 8 | 6877909 | C | T |
| rs1799983 | 25239655 | 2147 | F2 | umls:C0243026 | BeFree | Sepsis independently associated with HF, increased NOx, peripheral neutrophils, and fibrinogen levels, decreased prothrombin and the presence of the NOS3 (E298D) and NOS2A (exon 22) SNPs. | 0.080542884 | 2014 | NOS3 | 7 | 150999023 | T | G |
| rs1799983 | 25239655 | 4843 | NOS2 | umls:C0243026 | BeFree | Endothelial (NOS3 E298D) and inducible (NOS2 exon 22) nitric oxide synthase polymorphisms, as well as plasma NOx, influence sepsis development. | 0.201357209 | 2014 | NOS3 | 7 | 150999023 | T | G |
| rs1799983 | 25239655 | 2147 | F2 | umls:C0036690 | BeFree | Sepsis independently associated with HF, increased NOx, peripheral neutrophils, and fibrinogen levels, decreased prothrombin and the presence of the NOS3 (E298D) and NOS2A (exon 22) SNPs. | 0.000542884 | 2014 | NOS3 | 7 | 150999023 | T | G |
| rs1799983 | 25239655 | 4846 | NOS3 | umls:C0243026 | BeFree | Endothelial (NOS3 E298D) and inducible (NOS2 exon 22) nitric oxide synthase polymorphisms, as well as plasma NOx, influence sepsis development. | 0.12554839 | 2014 | NOS3 | 7 | 150999023 | T | G |
| rs1799983 | 25239655 | 339345 | NANOS2 | umls:C0036690 | BeFree | Endothelial (NOS3 E298D) and inducible (NOS2 exon 22) nitric oxide synthase polymorphisms, as well as plasma NOx, influence sepsis development. | 0.000542884 | 2014 | NOS3 | 7 | 150999023 | T | G |
| rs1799983 | 25239655 | 4846 | NOS3 | umls:C0036690 | BeFree | Endothelial (NOS3 E298D) and inducible (NOS2 exon 22) nitric oxide synthase polymorphisms, as well as plasma NOx, influence sepsis development. | 0.000814326 | 2014 | NOS3 | 7 | 150999023 | T | G |
| rs1799983 | 25239655 | 339345 | NANOS2 | umls:C0243026 | BeFree | Endothelial (NOS3 E298D) and inducible (NOS2 exon 22) nitric oxide synthase polymorphisms, as well as plasma NOx, influence sepsis development. | 0.000542884 | 2014 | NOS3 | 7 | 150999023 | T | G |
| rs1799983 | 18827745 | 4846 | NOS3 | umls:C0243026 | BeFree | The eNOS gene polymorphism at position 894 (G>T, Glu298Asp) resulting in T allele has been studied in the context of vascular diseases, but its role in sepsis has not yet been explored. | 0.12554839 | 2009 | NOS3 | 7 | 150999023 | T | G |
| rs1799983 | 18827745 | 4846 | NOS3 | umls:C0036690 | BeFree | The eNOS gene polymorphism at position 894 (G>T, Glu298Asp) resulting in T allele has been studied in the context of vascular diseases, but its role in sepsis has not yet been explored. | 0.000814326 | 2009 | NOS3 | 7 | 150999023 | T | G |
| rs1799983 | 25239655 | 4843 | NOS2 | umls:C0036690 | BeFree | Endothelial (NOS3 E298D) and inducible (NOS2 exon 22) nitric oxide synthase polymorphisms, as well as plasma NOx, influence sepsis development. | 0.001357209 | 2014 | NOS3 | 7 | 150999023 | T | G |
| rs1800896 | 20463618 | 5320 | PLA2G2A | umls:C0243026 | BeFree | Polymorphisms in TLR2 (rs3804099), TLR5 (rs5744105), IL10 (rs1800896), and PLA2G2A (rs1891320) genes were associated with sepsis. | 0.003452799 | 2010 | IL10 | 1 | 206773552 | T | C |
| rs1800896 | 20463618 | 5320 | PLA2G2A | umls:C0036690 | BeFree | Polymorphisms in TLR2 (rs3804099), TLR5 (rs5744105), IL10 (rs1800896), and PLA2G2A (rs1891320) genes were associated with sepsis. | 0.001085767 | 2010 | IL10 | 1 | 206773552 | T | C |
| rs1800896 | 20463618 | 7097 | TLR2 | umls:C0036690 | BeFree | Polymorphisms in TLR2 (rs3804099), TLR5 (rs5744105), IL10 (rs1800896), and PLA2G2A (rs1891320) genes were associated with sepsis. | 0.005428837 | 2010 | IL10 | 1 | 206773552 | T | C |
| rs1800896 | 20463618 | 7097 | TLR2 | umls:C0243026 | BeFree | Polymorphisms in TLR2 (rs3804099), TLR5 (rs5744105), IL10 (rs1800896), and PLA2G2A (rs1891320) genes were associated with sepsis. | 0.099902471 | 2010 | IL10 | 1 | 206773552 | T | C |
| rs1829975 | 22310353 | 5937 | RBMS1 | umls:C0243026 | GAD | [Beyond single-marker analyses: mining whole genome scans for insights into treatment responses in severe sepsis.] | 0.002367032 | 2013 | NA | 2 | 160928658 | C | T |
| rs187084 | 21633947 | 7124 | TNF | umls:C0036690 | BeFree | Both rs187084 and rs352162 were significantly associated with TNF-α production by peripheral blood leucocytes in response to bacterial DNA stimulation and a higher sepsis morbidity rate in patients with major trauma. | 0.021172466 | 2011 | TLR9 | 3 | 52227015 | A | G |
| rs187084 | 21633947 | 7124 | TNF | umls:C0243026 | BeFree | Both rs187084 and rs352162 were significantly associated with TNF-α production by peripheral blood leucocytes in response to bacterial DNA stimulation and a higher sepsis morbidity rate in patients with major trauma. | 0.286154284 | 2011 | TLR9 | 3 | 52227015 | A | G |
| rs1891320 | 20463618 | 7097 | TLR2 | umls:C0243026 | BeFree | Polymorphisms in TLR2 (rs3804099), TLR5 (rs5744105), IL10 (rs1800896), and PLA2G2A (rs1891320) genes were associated with sepsis. | 0.099902471 | 2010 | NA | 1 | 19970618 | C | T |
| rs1891320 | 20463618 | 5320 | PLA2G2A | umls:C0243026 | BeFree | Polymorphisms in TLR2 (rs3804099), TLR5 (rs5744105), IL10 (rs1800896), and PLA2G2A (rs1891320) genes were associated with sepsis. | 0.003452799 | 2010 | NA | 1 | 19970618 | C | T |
| rs1891320 | 20463618 | 5320 | PLA2G2A | umls:C0036690 | BeFree | Polymorphisms in TLR2 (rs3804099), TLR5 (rs5744105), IL10 (rs1800896), and PLA2G2A (rs1891320) genes were associated with sepsis. | 0.001085767 | 2010 | NA | 1 | 19970618 | C | T |
| rs1891320 | 20463618 | 7097 | TLR2 | umls:C0036690 | BeFree | Polymorphisms in TLR2 (rs3804099), TLR5 (rs5744105), IL10 (rs1800896), and PLA2G2A (rs1891320) genes were associated with sepsis. | 0.005428837 | 2010 | NA | 1 | 19970618 | C | T |
| rs2069912 | 18496716 | 5624 | PROC | umls:C0243026 | GAD | [Protein C rs2069912 C allele is associated with increased mortality from severe sepsis in North Americans of East Asian ancestry.] | 0.128001298 | 2008 | PROC | 2 | 127420615 | T | C |
| rs212388 | 24582067 | 117289 | TAGAP | umls:C0243026 | BeFree | We have previously suggested a correlation between the TAGAP-associated single nucleotide polymorphism rs212388 and protection from anal sepsis in Crohn's disease (CD) patients. | 0.000542884 | 2014 | NA | 6 | 159069404 | C | T |
| rs212388 | 24582067 | 117289 | TAGAP | umls:C0036690 | BeFree | We have previously suggested a correlation between the TAGAP-associated single nucleotide polymorphism rs212388 and protection from anal sepsis in Crohn's disease (CD) patients. | 0.000542884 | 2014 | NA | 6 | 159069404 | C | T |
| rs2234237 | 22798017 | 54210 | TREM1 | umls:C0243026 | BeFree | Of the three tested TREM-1 SNPs (rs144672509, rs2234237, and rs2234246), only rs2234237 (Ser25Thr) was significantly associated with sepsis prognosis in three inheritance models (p < 0.05). | 0.003257302 | 2012 | TREM1 | 6 | 41282728 | T | A |
| rs2234237 | 22798017 | 54210 | TREM1 | umls:C0036690 | BeFree | Of the three tested TREM-1 SNPs (rs144672509, rs2234237, and rs2234246), only rs2234237 (Ser25Thr) was significantly associated with sepsis prognosis in three inheritance models (p < 0.05). | 0.003257302 | 2012 | TREM1 | 6 | 41282728 | T | A |
| rs2234246 | 22798017 | 54210 | TREM1 | umls:C0036690 | BeFree | Of the three tested TREM-1 SNPs (rs144672509, rs2234237, and rs2234246), only rs2234237 (Ser25Thr) was significantly associated with sepsis prognosis in three inheritance models (p < 0.05). | 0.003257302 | 2012 | TREM1 | 6 | 41276002 | C | T |
| rs2234246 | 22798017 | 54210 | TREM1 | umls:C0243026 | BeFree | Of the three tested TREM-1 SNPs (rs144672509, rs2234237, and rs2234246), only rs2234237 (Ser25Thr) was significantly associated with sepsis prognosis in three inheritance models (p < 0.05). | 0.003257302 | 2012 | TREM1 | 6 | 41276002 | C | T |
| rs2664349 | 25000179 | 671 | BPI | umls:C0036690 | BeFree | Genotypes CT and TT of rs1143643 (the IL1β gene) and genotype GG of rs2664349GG (the MMP-16 gene) were associated with a significantly increased overall risk of developing sepsis (p = 0.03, p = 0.05 and p = 0.03), whereas genotypes AG of rs4358188 (the BPI gene) and CT of rs1799946 (the DEFβ1 gene) were associated with a significantly reduced risk of developing sepsis (p = 0.05 for both). | 0.000814326 | 2014 | MMP16 | 8 | 88077054 | G | A |
| rs2664349 | 25000179 | 3553 | IL1B | umls:C0036690 | BeFree | Genotypes CT and TT of rs1143643 (the IL1β gene) and genotype GG of rs2664349GG (the MMP-16 gene) were associated with a significantly increased overall risk of developing sepsis (p = 0.03, p = 0.05 and p = 0.03), whereas genotypes AG of rs4358188 (the BPI gene) and CT of rs1799946 (the DEFβ1 gene) were associated with a significantly reduced risk of developing sepsis (p = 0.05 for both). | 0.003528744 | 2014 | MMP16 | 8 | 88077054 | G | A |
| rs2664349 | 25000179 | 3553 | IL1B | umls:C0243026 | BeFree | Genotypes CT and TT of rs1143643 (the IL1β gene) and genotype GG of rs2664349GG (the MMP-16 gene) were associated with a significantly increased overall risk of developing sepsis (p = 0.03, p = 0.05 and p = 0.03), whereas genotypes AG of rs4358188 (the BPI gene) and CT of rs1799946 (the DEFβ1 gene) were associated with a significantly reduced risk of developing sepsis (p = 0.05 for both). | 0.102822318 | 2014 | MMP16 | 8 | 88077054 | G | A |
| rs2664349 | 25000179 | 4325 | MMP16 | umls:C0243026 | BeFree | Genotypes CT and TT of rs1143643 (the IL1β gene) and genotype GG of rs2664349GG (the MMP-16 gene) were associated with a significantly increased overall risk of developing sepsis (p = 0.03, p = 0.05 and p = 0.03), whereas genotypes AG of rs4358188 (the BPI gene) and CT of rs1799946 (the DEFβ1 gene) were associated with a significantly reduced risk of developing sepsis (p = 0.05 for both). | 0.002638474 | 2014 | MMP16 | 8 | 88077054 | G | A |
| rs2664349 | 25000179 | 4325 | MMP16 | umls:C0036690 | BeFree | Genotypes CT and TT of rs1143643 (the IL1β gene) and genotype GG of rs2664349GG (the MMP-16 gene) were associated with a significantly increased overall risk of developing sepsis (p = 0.03, p = 0.05 and p = 0.03), whereas genotypes AG of rs4358188 (the BPI gene) and CT of rs1799946 (the DEFβ1 gene) were associated with a significantly reduced risk of developing sepsis (p = 0.05 for both). | 0.000271442 | 2014 | MMP16 | 8 | 88077054 | G | A |
| rs2664349 | 25000179 | 671 | BPI | umls:C0243026 | BeFree | Genotypes CT and TT of rs1143643 (the IL1β gene) and genotype GG of rs2664349GG (the MMP-16 gene) were associated with a significantly increased overall risk of developing sepsis (p = 0.03, p = 0.05 and p = 0.03), whereas genotypes AG of rs4358188 (the BPI gene) and CT of rs1799946 (the DEFβ1 gene) were associated with a significantly reduced risk of developing sepsis (p = 0.05 for both). | 0.005819831 | 2014 | MMP16 | 8 | 88077054 | G | A |
| rs2910164 | 24701036 | 406938 | MIR146A | umls:C0243026 | BeFree | Our study has analyzed the association of sepsis with two functional miR-146a gene SNPs rs2910164 G/C and rs57095329 A/G in a Chinese Han population (226 sepsis cases; 206 healthy controls). | 0.000814326 | 2014 | LOC285628;MIR146A | 5 | 160485411 | C | G |
| rs2910164 | 24701036 | 406938 | MIR146A | umls:C0036690 | BeFree | Our study has analyzed the association of sepsis with two functional miR-146a gene SNPs rs2910164 G/C and rs57095329 A/G in a Chinese Han population (226 sepsis cases; 206 healthy controls). | 0.000814326 | 2014 | LOC285628;MIR146A | 5 | 160485411 | C | G |
| rs34557412 | 25454804 | 23495 | TNFRSF13B | umls:C0036690 | BeFree | Moreover, carriers of TACI-C104R displayed an undiagnosed mild to moderate hypogammaglobulinemia along with a significantly lower survival rate in the ICU, although lethal events were not attributed to sepsis. | 0.000271442 | 2014 | TNFRSF13B | 17 | 16948873 | A | G |
| rs34557412 | 25454804 | 23495 | TNFRSF13B | umls:C0243026 | BeFree | Moreover, carriers of TACI-C104R displayed an undiagnosed mild to moderate hypogammaglobulinemia along with a significantly lower survival rate in the ICU, although lethal events were not attributed to sepsis. | 0.000271442 | 2014 | TNFRSF13B | 17 | 16948873 | A | G |
| rs352162 | 21633947 | 7124 | TNF | umls:C0036690 | BeFree | Both rs187084 and rs352162 were significantly associated with TNF-α production by peripheral blood leucocytes in response to bacterial DNA stimulation and a higher sepsis morbidity rate in patients with major trauma. | 0.021172466 | 2011 | NA | 3 | 52218953 | T | C |
| rs352162 | 21633947 | 7124 | TNF | umls:C0243026 | BeFree | Both rs187084 and rs352162 were significantly associated with TNF-α production by peripheral blood leucocytes in response to bacterial DNA stimulation and a higher sepsis morbidity rate in patients with major trauma. | 0.286154284 | 2011 | NA | 3 | 52218953 | T | C |
| rs3759129 | 21427539 | 362 | AQP5 | umls:C0036690 | BeFree | Because the aquaporin (AQP) 5 promoter -1364A/C polymorphism is associated with altered AQP5 expression, this association could have an impact on key mechanisms in sepsis, such as cell migration, activity of the rennin-angiotensin- aldosterone system (RAAS), and water transport across biologic membranes. | 0.000542884 | 2011 | AQP5;LOC101927318 | 12 | 49960654 | A | C |
| rs3759129 | 21427539 | 362 | AQP5 | umls:C0243026 | BeFree | Because the aquaporin (AQP) 5 promoter -1364A/C polymorphism is associated with altered AQP5 expression, this association could have an impact on key mechanisms in sepsis, such as cell migration, activity of the rennin-angiotensin- aldosterone system (RAAS), and water transport across biologic membranes. | 0.000542884 | 2011 | AQP5;LOC101927318 | 12 | 49960654 | A | C |
| rs3804099 | 20463618 | 7097 | TLR2 | umls:C0243026 | BeFree | Polymorphisms in TLR2 (rs3804099), TLR5 (rs5744105), IL10 (rs1800896), and PLA2G2A (rs1891320) genes were associated with sepsis. | 0.099902471 | 2010 | TLR2 | 4 | 153703504 | T | C |
| rs3804099 | 20463618 | 5320 | PLA2G2A | umls:C0036690 | BeFree | Polymorphisms in TLR2 (rs3804099), TLR5 (rs5744105), IL10 (rs1800896), and PLA2G2A (rs1891320) genes were associated with sepsis. | 0.001085767 | 2010 | TLR2 | 4 | 153703504 | T | C |
| rs3804099 | 20463618 | 7097 | TLR2 | umls:C0036690 | BeFree | Polymorphisms in TLR2 (rs3804099), TLR5 (rs5744105), IL10 (rs1800896), and PLA2G2A (rs1891320) genes were associated with sepsis. | 0.005428837 | 2010 | TLR2 | 4 | 153703504 | T | C |
| rs3804099 | 20463618 | 5320 | PLA2G2A | umls:C0243026 | BeFree | Polymorphisms in TLR2 (rs3804099), TLR5 (rs5744105), IL10 (rs1800896), and PLA2G2A (rs1891320) genes were associated with sepsis. | 0.003452799 | 2010 | TLR2 | 4 | 153703504 | T | C |
| rs4358188 | 25000179 | 671 | BPI | umls:C0243026 | BeFree | Genotypes CT and TT of rs1143643 (the IL1β gene) and genotype GG of rs2664349GG (the MMP-16 gene) were associated with a significantly increased overall risk of developing sepsis (p = 0.03, p = 0.05 and p = 0.03), whereas genotypes AG of rs4358188 (the BPI gene) and CT of rs1799946 (the DEFβ1 gene) were associated with a significantly reduced risk of developing sepsis (p = 0.05 for both). | 0.005819831 | 2014 | BPI;LOC105372612 | 20 | 38318446 | G | A |
| rs4358188 | 25000179 | 3553 | IL1B | umls:C0243026 | BeFree | Genotypes CT and TT of rs1143643 (the IL1β gene) and genotype GG of rs2664349GG (the MMP-16 gene) were associated with a significantly increased overall risk of developing sepsis (p = 0.03, p = 0.05 and p = 0.03), whereas genotypes AG of rs4358188 (the BPI gene) and CT of rs1799946 (the DEFβ1 gene) were associated with a significantly reduced risk of developing sepsis (p = 0.05 for both). | 0.102822318 | 2014 | BPI;LOC105372612 | 20 | 38318446 | G | A |
| rs4358188 | 25000179 | 4325 | MMP16 | umls:C0243026 | BeFree | Genotypes CT and TT of rs1143643 (the IL1β gene) and genotype GG of rs2664349GG (the MMP-16 gene) were associated with a significantly increased overall risk of developing sepsis (p = 0.03, p = 0.05 and p = 0.03), whereas genotypes AG of rs4358188 (the BPI gene) and CT of rs1799946 (the DEFβ1 gene) were associated with a significantly reduced risk of developing sepsis (p = 0.05 for both). | 0.002638474 | 2014 | BPI;LOC105372612 | 20 | 38318446 | G | A |
| rs4358188 | 25000179 | 671 | BPI | umls:C0036690 | BeFree | Genotypes CT and TT of rs1143643 (the IL1β gene) and genotype GG of rs2664349GG (the MMP-16 gene) were associated with a significantly increased overall risk of developing sepsis (p = 0.03, p = 0.05 and p = 0.03), whereas genotypes AG of rs4358188 (the BPI gene) and CT of rs1799946 (the DEFβ1 gene) were associated with a significantly reduced risk of developing sepsis (p = 0.05 for both). | 0.000814326 | 2014 | BPI;LOC105372612 | 20 | 38318446 | G | A |
| rs4358188 | 25000179 | 4325 | MMP16 | umls:C0036690 | BeFree | Genotypes CT and TT of rs1143643 (the IL1β gene) and genotype GG of rs2664349GG (the MMP-16 gene) were associated with a significantly increased overall risk of developing sepsis (p = 0.03, p = 0.05 and p = 0.03), whereas genotypes AG of rs4358188 (the BPI gene) and CT of rs1799946 (the DEFβ1 gene) were associated with a significantly reduced risk of developing sepsis (p = 0.05 for both). | 0.000271442 | 2014 | BPI;LOC105372612 | 20 | 38318446 | G | A |
| rs4358188 | 25000179 | 3553 | IL1B | umls:C0036690 | BeFree | Genotypes CT and TT of rs1143643 (the IL1β gene) and genotype GG of rs2664349GG (the MMP-16 gene) were associated with a significantly increased overall risk of developing sepsis (p = 0.03, p = 0.05 and p = 0.03), whereas genotypes AG of rs4358188 (the BPI gene) and CT of rs1799946 (the DEFβ1 gene) were associated with a significantly reduced risk of developing sepsis (p = 0.05 for both). | 0.003528744 | 2014 | BPI;LOC105372612 | 20 | 38318446 | G | A |
| rs4723738 | 22310353 | 83930 | STARD3NL | umls:C0243026 | GAD | [Beyond single-marker analyses: mining whole genome scans for insights into treatment responses in severe sepsis.] | 0.002367032 | 2013 | STARD3NL | 7 | 38201307 | A | G |
| rs4880 | 25497738 | 2876 | GPX1 | umls:C0036690 | BeFree | Evaluating the subgroup of 293 ICU patients with sepsis, a pooled analysis including two genetic variants GPx1 and SOD2 (47C>T SNP, rs4880; protein variant in MnSOD: Ala-9Val) showed a significant difference in relation to progression to septic shock. | 0.000271442 | 2014 | SOD2 | 6 | 159692840 | A | G |
| rs4880 | 25497738 | 2876 | GPX1 | umls:C0243026 | BeFree | Evaluating the subgroup of 293 ICU patients with sepsis, a pooled analysis including two genetic variants GPx1 and SOD2 (47C>T SNP, rs4880; protein variant in MnSOD: Ala-9Val) showed a significant difference in relation to progression to septic shock. | 0.000271442 | 2014 | SOD2 | 6 | 159692840 | A | G |
| rs4919510 | 24743625 | 693193 | MIR608 | umls:C0036690 | BeFree | Our results indicate that the rs4919510G/C SNP in hsa-mir-608 may be a prognostic biomarker for sepsis in patients with major trauma. | 0.000271442 | 2015 | SEMA4G;MIR608 | 10 | 100975021 | C | G |
| rs4919510 | 24743625 | 693193 | MIR608 | umls:C0243026 | BeFree | Our results indicate that the rs4919510G/C SNP in hsa-mir-608 may be a prognostic biomarker for sepsis in patients with major trauma. | 0.000271442 | 2015 | SEMA4G;MIR608 | 10 | 100975021 | C | G |
| rs497116 | 22615879 | 100506742 | CASP12 | umls:C0036690 | BeFree | In humans, the C allele at CASP12 rs497116 has been associated with an increased risk of sepsis. | 0.001900093 | 2012 | CASP12 | 11 | 104892390 | A | G |
| rs497116 | 22615879 | 100506742 | CASP12 | umls:C0243026 | BeFree | In humans, the C allele at CASP12 rs497116 has been associated with an increased risk of sepsis. | 0.001900093 | 2012 | CASP12 | 11 | 104892390 | A | G |
| rs4986790 | 18034244 | 7099 | TLR4 | umls:C0036690 | BeFree | Two commonly occurring SNPs in the human TLR4 gene (Asp299Gly and Thr399Ile) have been shown to be associated with increased risk of Gram-negative bacteremia in sepsis patients and with susceptibility to inflammatory bowel disease. | 0.009771907 | 2008 | TLR4 | 9 | 117713024 | A | G |
| rs4986790 | 12404174 | 7099 | TLR4 | umls:C0036690 | BeFree | Our study investigated the association between TLR4 mutations (Asp299Gly and Thr399Ile) and CD14 polymorphism(s) with outcome in an intensive care unit (ICU) population at risk for sepsis. | 0.009771907 | 2002 | TLR4 | 9 | 117713024 | A | G |
| rs4986790 | 12404174 | 4695 | NDUFA2 | umls:C0036690 | BeFree | Our study investigated the association between TLR4 mutations (Asp299Gly and Thr399Ile) and CD14 polymorphism(s) with outcome in an intensive care unit (ICU) population at risk for sepsis. | 0.005157396 | 2002 | TLR4 | 9 | 117713024 | A | G |
| rs4986790 | 12404174 | 929 | CD14 | umls:C0036690 | BeFree | Our study investigated the association between TLR4 mutations (Asp299Gly and Thr399Ile) and CD14 polymorphism(s) with outcome in an intensive care unit (ICU) population at risk for sepsis. | 0.005157396 | 2002 | TLR4 | 9 | 117713024 | A | G |
| rs4986790 | 12404174 | 7099 | TLR4 | umls:C0243026 | BeFree | Our study investigated the association between TLR4 mutations (Asp299Gly and Thr399Ile) and CD14 polymorphism(s) with outcome in an intensive care unit (ICU) population at risk for sepsis. | 0.243539115 | 2002 | TLR4 | 9 | 117713024 | A | G |
| rs4986790 | 18034244 | 7099 | TLR4 | umls:C0243026 | BeFree | Two commonly occurring SNPs in the human TLR4 gene (Asp299Gly and Thr399Ile) have been shown to be associated with increased risk of Gram-negative bacteremia in sepsis patients and with susceptibility to inflammatory bowel disease. | 0.243539115 | 2008 | TLR4 | 9 | 117713024 | A | G |
| rs4986790 | 12404174 | 929 | CD14 | umls:C0243026 | BeFree | Our study investigated the association between TLR4 mutations (Asp299Gly and Thr399Ile) and CD14 polymorphism(s) with outcome in an intensive care unit (ICU) population at risk for sepsis. | 0.043301349 | 2002 | TLR4 | 9 | 117713024 | A | G |
| rs4986790 | 21968286 | 7099 | TLR4 | umls:C0036690 | BeFree | In conclusion, differences in distribution of TLR4 polymorphisms Asp299Gly and Thr399Ile in European populations are most likely due to a combination of population migration events combined with selection due to sepsis. | 0.009771907 | 2012 | TLR4 | 9 | 117713024 | A | G |
| rs4986790 | 15520404 | 7099 | TLR4 | umls:C0243026 | GAD | [Candidate single nucleotide polymorphisms (SNPs) within bacterial recognition (TLR4 +896, CD14 -159) and inflammatory response (TNF-alpha -308, IL-1beta -31, IL-6 -174) loci were evaluated for association with increased risk for severe sepsis (sepsis plus organ dysfunction or septic shock) and mortality.] | 0.243539115 | 2004 | TLR4 | 9 | 117713024 | A | G |
| rs4986790 | 25427560 | 7099 | TLR4 | umls:C0036690 | BeFree | Furthermore, the cosegregating TLR4 polymorphisms Asp299Gly and Thr399Ile were independent risk factors for the development of both sepsis and pneumonia (OR: 3.55; 95% CI: 1.21-10.4, P=0.021 and OR: 3.57, 95% CI: 1.3-9.86, P=0.014, respectively). | 0.009771907 | 2014 | TLR4 | 9 | 117713024 | A | G |
| rs4986790 | 12404174 | 4695 | NDUFA2 | umls:C0243026 | BeFree | Our study investigated the association between TLR4 mutations (Asp299Gly and Thr399Ile) and CD14 polymorphism(s) with outcome in an intensive care unit (ICU) population at risk for sepsis. | 0.005428837 | 2002 | TLR4 | 9 | 117713024 | A | G |
| rs4986790 | 25454804 | 7099 | TLR4 | umls:C0036690 | BeFree | Interestingly, TLR4-D299G, TLR4-T399I and BAFFR-P21R carriage was associated with a lower risk of ICU-acquired sepsis. | 0.009771907 | 2014 | TLR4 | 9 | 117713024 | A | G |
| rs4986790 | 22537674 | 7099 | TLR4 | umls:C0243026 | BeFree | Lack of association between TLR4 Asp299Gly and Thr399Ile polymorphisms and sepsis susceptibility: a meta-analysis. | 0.243539115 | 2012 | TLR4 | 9 | 117713024 | A | G |
| rs4986790 | 25454804 | 7099 | TLR4 | umls:C0243026 | BeFree | Interestingly, TLR4-D299G, TLR4-T399I and BAFFR-P21R carriage was associated with a lower risk of ICU-acquired sepsis. | 0.243539115 | 2014 | TLR4 | 9 | 117713024 | A | G |
| rs4986790 | 22537674 | 7099 | TLR4 | umls:C0036690 | BeFree | Lack of association between TLR4 Asp299Gly and Thr399Ile polymorphisms and sepsis susceptibility: a meta-analysis. | 0.009771907 | 2012 | TLR4 | 9 | 117713024 | A | G |
| rs4986790 | 25454804 | 115650 | TNFRSF13C | umls:C0243026 | BeFree | Interestingly, TLR4-D299G, TLR4-T399I and BAFFR-P21R carriage was associated with a lower risk of ICU-acquired sepsis. | 0.000271442 | 2014 | TLR4 | 9 | 117713024 | A | G |
| rs4986790 | 25427560 | 7099 | TLR4 | umls:C0243026 | BeFree | Furthermore, the cosegregating TLR4 polymorphisms Asp299Gly and Thr399Ile were independent risk factors for the development of both sepsis and pneumonia (OR: 3.55; 95% CI: 1.21-10.4, P=0.021 and OR: 3.57, 95% CI: 1.3-9.86, P=0.014, respectively). | 0.243539115 | 2014 | TLR4 | 9 | 117713024 | A | G |
| rs4986790 | 25454804 | 115650 | TNFRSF13C | umls:C0036690 | BeFree | Interestingly, TLR4-D299G, TLR4-T399I and BAFFR-P21R carriage was associated with a lower risk of ICU-acquired sepsis. | 0.000271442 | 2014 | TLR4 | 9 | 117713024 | A | G |
| rs4986790 | 21968286 | 7099 | TLR4 | umls:C0243026 | BeFree | In conclusion, differences in distribution of TLR4 polymorphisms Asp299Gly and Thr399Ile in European populations are most likely due to a combination of population migration events combined with selection due to sepsis. | 0.243539115 | 2012 | TLR4 | 9 | 117713024 | A | G |
| rs4986791 | 12404174 | 4695 | NDUFA2 | umls:C0243026 | BeFree | Our study investigated the association between TLR4 mutations (Asp299Gly and Thr399Ile) and CD14 polymorphism(s) with outcome in an intensive care unit (ICU) population at risk for sepsis. | 0.005428837 | 2002 | TLR4 | 9 | 117713324 | C | T |
| rs4986791 | 12404174 | 7099 | TLR4 | umls:C0243026 | BeFree | Our study investigated the association between TLR4 mutations (Asp299Gly and Thr399Ile) and CD14 polymorphism(s) with outcome in an intensive care unit (ICU) population at risk for sepsis. | 0.243539115 | 2002 | TLR4 | 9 | 117713324 | C | T |
| rs4986791 | 12404174 | 4695 | NDUFA2 | umls:C0036690 | BeFree | Our study investigated the association between TLR4 mutations (Asp299Gly and Thr399Ile) and CD14 polymorphism(s) with outcome in an intensive care unit (ICU) population at risk for sepsis. | 0.005157396 | 2002 | TLR4 | 9 | 117713324 | C | T |
| rs4986791 | 22537674 | 7099 | TLR4 | umls:C0243026 | BeFree | Lack of association between TLR4 Asp299Gly and Thr399Ile polymorphisms and sepsis susceptibility: a meta-analysis. | 0.243539115 | 2012 | TLR4 | 9 | 117713324 | C | T |
| rs4986791 | 12404174 | 929 | CD14 | umls:C0036690 | BeFree | Our study investigated the association between TLR4 mutations (Asp299Gly and Thr399Ile) and CD14 polymorphism(s) with outcome in an intensive care unit (ICU) population at risk for sepsis. | 0.005157396 | 2002 | TLR4 | 9 | 117713324 | C | T |
| rs4986791 | 21968286 | 7099 | TLR4 | umls:C0036690 | BeFree | In conclusion, differences in distribution of TLR4 polymorphisms Asp299Gly and Thr399Ile in European populations are most likely due to a combination of population migration events combined with selection due to sepsis. | 0.009771907 | 2012 | TLR4 | 9 | 117713324 | C | T |
| rs4986791 | 25454804 | 7099 | TLR4 | umls:C0243026 | BeFree | Interestingly, TLR4-D299G, TLR4-T399I and BAFFR-P21R carriage was associated with a lower risk of ICU-acquired sepsis. | 0.243539115 | 2014 | TLR4 | 9 | 117713324 | C | T |
| rs4986791 | 18034244 | 7099 | TLR4 | umls:C0036690 | BeFree | Two commonly occurring SNPs in the human TLR4 gene (Asp299Gly and Thr399Ile) have been shown to be associated with increased risk of Gram-negative bacteremia in sepsis patients and with susceptibility to inflammatory bowel disease. | 0.009771907 | 2008 | TLR4 | 9 | 117713324 | C | T |
| rs4986791 | 12404174 | 7099 | TLR4 | umls:C0036690 | BeFree | Our study investigated the association between TLR4 mutations (Asp299Gly and Thr399Ile) and CD14 polymorphism(s) with outcome in an intensive care unit (ICU) population at risk for sepsis. | 0.009771907 | 2002 | TLR4 | 9 | 117713324 | C | T |
| rs4986791 | 22537674 | 7099 | TLR4 | umls:C0036690 | BeFree | Lack of association between TLR4 Asp299Gly and Thr399Ile polymorphisms and sepsis susceptibility: a meta-analysis. | 0.009771907 | 2012 | TLR4 | 9 | 117713324 | C | T |
| rs4986791 | 25454804 | 7099 | TLR4 | umls:C0036690 | BeFree | Interestingly, TLR4-D299G, TLR4-T399I and BAFFR-P21R carriage was associated with a lower risk of ICU-acquired sepsis. | 0.009771907 | 2014 | TLR4 | 9 | 117713324 | C | T |
| rs4986791 | 12404174 | 929 | CD14 | umls:C0243026 | BeFree | Our study investigated the association between TLR4 mutations (Asp299Gly and Thr399Ile) and CD14 polymorphism(s) with outcome in an intensive care unit (ICU) population at risk for sepsis. | 0.043301349 | 2002 | TLR4 | 9 | 117713324 | C | T |
| rs4986791 | 25454804 | 115650 | TNFRSF13C | umls:C0243026 | BeFree | Interestingly, TLR4-D299G, TLR4-T399I and BAFFR-P21R carriage was associated with a lower risk of ICU-acquired sepsis. | 0.000271442 | 2014 | TLR4 | 9 | 117713324 | C | T |
| rs4986791 | 25427560 | 7099 | TLR4 | umls:C0036690 | BeFree | Furthermore, the cosegregating TLR4 polymorphisms Asp299Gly and Thr399Ile were independent risk factors for the development of both sepsis and pneumonia (OR: 3.55; 95% CI: 1.21-10.4, P=0.021 and OR: 3.57, 95% CI: 1.3-9.86, P=0.014, respectively). | 0.009771907 | 2014 | TLR4 | 9 | 117713324 | C | T |
| rs4986791 | 18034244 | 7099 | TLR4 | umls:C0243026 | BeFree | Two commonly occurring SNPs in the human TLR4 gene (Asp299Gly and Thr399Ile) have been shown to be associated with increased risk of Gram-negative bacteremia in sepsis patients and with susceptibility to inflammatory bowel disease. | 0.243539115 | 2008 | TLR4 | 9 | 117713324 | C | T |
| rs4986791 | 25427560 | 7099 | TLR4 | umls:C0243026 | BeFree | Furthermore, the cosegregating TLR4 polymorphisms Asp299Gly and Thr399Ile were independent risk factors for the development of both sepsis and pneumonia (OR: 3.55; 95% CI: 1.21-10.4, P=0.021 and OR: 3.57, 95% CI: 1.3-9.86, P=0.014, respectively). | 0.243539115 | 2014 | TLR4 | 9 | 117713324 | C | T |
| rs4986791 | 21968286 | 7099 | TLR4 | umls:C0243026 | BeFree | In conclusion, differences in distribution of TLR4 polymorphisms Asp299Gly and Thr399Ile in European populations are most likely due to a combination of population migration events combined with selection due to sepsis. | 0.243539115 | 2012 | TLR4 | 9 | 117713324 | C | T |
| rs4986791 | 25454804 | 115650 | TNFRSF13C | umls:C0036690 | BeFree | Interestingly, TLR4-D299G, TLR4-T399I and BAFFR-P21R carriage was associated with a lower risk of ICU-acquired sepsis. | 0.000271442 | 2014 | TLR4 | 9 | 117713324 | C | T |
| rs57095329 | 24701036 | 406938 | MIR146A | umls:C0036690 | BeFree | Our study has analyzed the association of sepsis with two functional miR-146a gene SNPs rs2910164 G/C and rs57095329 A/G in a Chinese Han population (226 sepsis cases; 206 healthy controls). | 0.000814326 | 2014 | LOC285628 | 5 | 160467840 | A | G |
| rs57095329 | 24701036 | 406938 | MIR146A | umls:C0243026 | BeFree | Our study has analyzed the association of sepsis with two functional miR-146a gene SNPs rs2910164 G/C and rs57095329 A/G in a Chinese Han population (226 sepsis cases; 206 healthy controls). | 0.000814326 | 2014 | LOC285628 | 5 | 160467840 | A | G |
| rs5743708 | 18249133 | 7097 | TLR2 | umls:C0036690 | BeFree | Single nucleotide polymorphisms (SNPs) Arg753Gln and Arg677Trp affect TLR2 responsiveness and may contribute to the course of sepsis, which is associated with substantial morbidity and mortality during intensive care treatment. | 0.005428837 | 2008 | TLR2 | 4 | 153705165 | G | A |
| rs5743708 | 18249133 | 7097 | TLR2 | umls:C0243026 | BeFree | Single nucleotide polymorphisms (SNPs) Arg753Gln and Arg677Trp affect TLR2 responsiveness and may contribute to the course of sepsis, which is associated with substantial morbidity and mortality during intensive care treatment. | 0.099902471 | 2008 | TLR2 | 4 | 153705165 | G | A |
| rs5744105 | 20463618 | 7097 | TLR2 | umls:C0036690 | BeFree | Polymorphisms in TLR2 (rs3804099), TLR5 (rs5744105), IL10 (rs1800896), and PLA2G2A (rs1891320) genes were associated with sepsis. | 0.005428837 | 2010 | TLR5 | 1 | 223142735 | G | C |
| rs5744105 | 20463618 | 5320 | PLA2G2A | umls:C0036690 | BeFree | Polymorphisms in TLR2 (rs3804099), TLR5 (rs5744105), IL10 (rs1800896), and PLA2G2A (rs1891320) genes were associated with sepsis. | 0.001085767 | 2010 | TLR5 | 1 | 223142735 | G | C |
| rs5744105 | 20463618 | 7097 | TLR2 | umls:C0243026 | BeFree | Polymorphisms in TLR2 (rs3804099), TLR5 (rs5744105), IL10 (rs1800896), and PLA2G2A (rs1891320) genes were associated with sepsis. | 0.099902471 | 2010 | TLR5 | 1 | 223142735 | G | C |
| rs5744105 | 20463618 | 5320 | PLA2G2A | umls:C0243026 | BeFree | Polymorphisms in TLR2 (rs3804099), TLR5 (rs5744105), IL10 (rs1800896), and PLA2G2A (rs1891320) genes were associated with sepsis. | 0.003452799 | 2010 | TLR5 | 1 | 223142735 | G | C |
| rs6025 | 20202226 | 2153 | F5 | umls:C0243026 | GAD | [FVL carrier status did not predict either susceptibility to or outcome from Gram negative, Escherichia coli or Streptococcus pneumoniae sepsis.] | 0.026013608 | 2010 | F5 | 1 | 169549811 | C | T |
| rs77874543 | 25454804 | 7099 | TLR4 | umls:C0036690 | BeFree | Interestingly, TLR4-D299G, TLR4-T399I and BAFFR-P21R carriage was associated with a lower risk of ICU-acquired sepsis. | 0.009771907 | 2014 | TNFRSF13C | 22 | 41926712 | G | C |
| rs77874543 | 25454804 | 115650 | TNFRSF13C | umls:C0036690 | BeFree | Interestingly, TLR4-D299G, TLR4-T399I and BAFFR-P21R carriage was associated with a lower risk of ICU-acquired sepsis. | 0.000271442 | 2014 | TNFRSF13C | 22 | 41926712 | G | C |
| rs77874543 | 25454804 | 115650 | TNFRSF13C | umls:C0243026 | BeFree | Interestingly, TLR4-D299G, TLR4-T399I and BAFFR-P21R carriage was associated with a lower risk of ICU-acquired sepsis. | 0.000271442 | 2014 | TNFRSF13C | 22 | 41926712 | G | C |
| rs77874543 | 25454804 | 7099 | TLR4 | umls:C0243026 | BeFree | Interestingly, TLR4-D299G, TLR4-T399I and BAFFR-P21R carriage was associated with a lower risk of ICU-acquired sepsis. | 0.243539115 | 2014 | TNFRSF13C | 22 | 41926712 | G | C |
| rs9770242 | 16555615 | 10135 | NAMPT | umls:C0243026 | BeFree | DNA sequencing identified two single nucleotide polymorphisms (SNPs) in the PBEF promoter (T-1001G, C-1543T), which were genotyped in a Caucasian cohort of sepsis-associated ALI patients. | 0.000542884 | 2005 | NAMPT | 7 | 106285885 | C | A |
| rs9770242 | 16555615 | 10135 | NAMPT | umls:C0036690 | BeFree | DNA sequencing identified two single nucleotide polymorphisms (SNPs) in the PBEF promoter (T-1001G, C-1543T), which were genotyped in a Caucasian cohort of sepsis-associated ALI patients. | 0.000542884 | 2005 | NAMPT | 7 | 106285885 | C | A |
| rs9770242 | 16877634 | 10135 | NAMPT | umls:C0243026 | BeFree | PBEF protein levels were elevated in human bronchoalveolar lavage and serum samples from patients with ALI, and DNA sequencing identified two single nucleotide polymorphisms in the PBEF promoter (T-1001G, C-1543T) that were overrepresented in patients with sepsis-induced ALI. | 0.000542884 | 2006 | NAMPT | 7 | 106285885 | C | A |
| rs9770242 | 16877634 | 10135 | NAMPT | umls:C0036690 | BeFree | PBEF protein levels were elevated in human bronchoalveolar lavage and serum samples from patients with ALI, and DNA sequencing identified two single nucleotide polymorphisms in the PBEF promoter (T-1001G, C-1543T) that were overrepresented in patients with sepsis-induced ALI. | 0.000542884 | 2006 | NAMPT | 7 | 106285885 | C | A |
