PedAM

Pediatric Disease Annotations & Medicines


	seminoma

Disease ID	1029
Disease	seminoma
Definition	A radiosensitive, malignant neoplasm of the testis, thought to be derived from primordial germ cells of the sexually undifferentiated embryonic gonad. There are three variants: classical (typical), the most common type; anaplastic; and spermatocytic. The classical seminoma is composed of fairly well differentiated sheets or cords of uniform polygonal or round cells (seminoma cells), each cell having abundant clear cytoplasm, distinct cell membranes, a centrally placed round nucleus, and one or more nucleoli. In the female, a grossly and histologically identical neoplasm, known as dysgerminoma, occurs. (Dorland, 27th ed)
Synonym	[m]seminoma nos [m]seminoma nos (morphologic abnormality) [m]seminomas [m]seminomas (morphologic abnormality) seminoma (disorder) seminoma (morphologic abnormality) seminoma [disease/finding] seminoma of testis seminoma of testis (disorder) seminoma of the testis seminoma testicular cancer seminoma testis seminoma, malignant seminoma, no icd-o subtype seminoma, no icd-o subtype (morphologic abnormality) seminoma, no international classification of diseases for oncology subtype seminoma, no international classification of diseases for oncology subtype (morphologic abnormality) seminoma, nos seminoma, pure seminoma, testicular seminomas testicle cancer, seminoma testicular cancer, seminoma testicular seminoma testicular seminoma pure testis cancer, seminoma testis, seminoma
DOID	DOID:4440 DOID:5842
UMLS	C0036631
MeSH	D018239
SNOMED-CT	SNOMEDCT_US_2016_09_01:255107005;SNOMEDCT_US_2016_09_01:443675005
Comorbidity	UMLS \| Disease \| Sentences' Count(Total Sentences:25) C0039590 \| testicular cancer \| 3 C0010417 \| undescended testis \| 3 C0206659 \| embryonal carcinoma \| 3 C0206695 \| neuroendocrine carcinoma \| 2 C0039538 \| teratoma \| 2 C0039538 \| teratomas \| 2 C0206660 \| germinoma \| 1 C1261473 \| sarcoma \| 1 C0021845 \| bowel perforation \| 1 C0007099 \| carcinoma in situ \| 1 C0018051 \| gonadal dysgenesis \| 1 C0740345 \| germ cell cancer \| 1 C0014038 \| encephalitis \| 1 C0020538 \| hypertension \| 1 C0494165 \| hepatic metastasis \| 1 C0014145 \| yolk sac tumor \| 1 C0020437 \| hypercalcemia \| 1 C0039585 \| androgen insensitivity syndrome \| 1 C0206660 \| germinomas \| 1 C0020541 \| portal hypertension \| 1 C0036202 \| sarcoidosis \| 1 C0007133 \| papillary carcinoma \| 1 C0206695 \| neuroendocrine carcinomas \| 1 C1261473 \| sarcomas \| 1 C0019163 \| hepatitis b \| 1
Curated Gene	Entrez_id \| Symbol \| Resource(Total Genes:3) HRAS \| 3265 \| CTD_human FGFR3 \| 2261 \| CTD_human ENTPD6 \| 955 \| CTD_human
Inferring Gene	(Waiting for update.)
Text Mined Gene	Entrez_id \| Symbol \| Score \| Resource(Total Genes:273) 56603 \| CYP26B1 \| DISEASES 5898 \| RALA \| DISEASES 1856 \| DVL2 \| DISEASES 51087 \| YBX2 \| DISEASES 4830 \| NME1 \| DISEASES 6515 \| SLC2A3 \| DISEASES 7544 \| ZFY \| DISEASES 2249 \| FGF4 \| DISEASES 7022 \| TFAP2C \| DISEASES 2099 \| ESR1 \| DISEASES 3956 \| LGALS1 \| DISEASES 1113 \| CHGA \| DISEASES 57167 \| SALL4 \| DISEASES 1917 \| EEF1A2 \| DISEASES 5716 \| PSMD10 \| DISEASES 10735 \| STAG2 \| DISEASES 268 \| AMH \| DISEASES 1048 \| CEACAM5 \| DISEASES 708 \| C1QBP \| DISEASES 4254 \| KITLG \| DISEASES 2026 \| ENO2 \| DISEASES 79923 \| NANOG \| DISEASES 55907 \| CMAS \| DISEASES 1653 \| DDX1 \| DISEASES 79084 \| WDR77 \| DISEASES 55640 \| FLVCR2 \| DISEASES 654231 \| OCM \| DISEASES 3623 \| INHA \| DISEASES 9271 \| PIWIL1 \| DISEASES 6662 \| SOX9 \| DISEASES 6237 \| RRAS \| DISEASES 60385 \| TSKS \| DISEASES 968 \| CD68 \| DISEASES 6320 \| CLEC11A \| DISEASES 1618 \| DAZL \| DISEASES 56165 \| TDRD1 \| DISEASES 3852 \| KRT5 \| DISEASES 9590 \| AKAP12 \| DISEASES 83639 \| TEX101 \| DISEASES 79727 \| LIN28A \| DISEASES 4678 \| NASP \| DISEASES 8900 \| CCNA1 \| DISEASES 3845 \| KRAS \| DISEASES 5156 \| PDGFRA \| DISEASES 4440 \| MSI1 \| DISEASES 4951 \| OCM2 \| DISEASES 8521 \| GCM1 \| DISEASES 5460 \| POU5F1 \| DISEASES 11270 \| NRM \| DISEASES 1588 \| CYP19A1 \| DISEASES 55729 \| ATF7IP \| DISEASES 894 \| CCND2 \| DISEASES 999 \| CDH1 \| DISEASES 10681 \| GNB5 \| DISEASES 114294 \| LACTB \| DISEASES 57148 \| RALGAPB \| DISEASES 8030 \| CCDC6 \| DISEASES 6855 \| SYP \| DISEASES 943 \| TNFRSF8 \| DISEASES 8975 \| USP13 \| DISEASES 3299 \| HSF4 \| DISEASES 60482 \| SLC5A7 \| DISEASES 51191 \| HERC5 \| DISEASES 1788 \| DNMT3A \| DISEASES 25930 \| PTPN23 \| DISEASES 55749 \| CCAR1 \| DISEASES 23598 \| PATZ1 \| DISEASES 50846 \| DHH \| DISEASES 7157 \| TP53 \| DISEASES 29947 \| DNMT3L \| DISEASES 4059 \| BCAM \| DISEASES 84432 \| PROK1 \| DISEASES 5899 \| RALB \| DISEASES 890 \| CCNA2 \| DISEASES 6581 \| SLC22A3 \| DISEASES 346673 \| STRA8 \| DISEASES 4103 \| MAGEA4 \| DISEASES 8795 \| TNFRSF10B \| DISEASES 57689 \| LRRC4C \| DISEASES 8501 \| SLC43A1 \| DISEASES 23457 \| ABCB9 \| DISEASES 3948 \| LDHC \| DISEASES 4613 \| MYCN \| DISEASES 2697 \| GJA1 \| DISEASES 9947 \| MAGEC1 \| DISEASES 50940 \| PDE11A \| DISEASES 4325 \| MMP16 \| DISEASES 3815 \| KIT \| DISEASES 3460 \| IFNGR2 \| DISEASES 1346 \| COX7A1 \| DISEASES 10630 \| PDPN \| DISEASES 3973 \| LHCGR \| DISEASES 251 \| ALPPL2 \| DISEASES 248 \| ALPI \| DISEASES 3015 \| H2AFZ \| DISEASES 64321 \| SOX17 \| DISEASES 79937 \| CNTNAP3 \| DISEASES 83592 \| AKR1E2 \| DISEASES 51266 \| CLEC1B \| DISEASES 143689 \| PIWIL4 \| DISEASES 5055 \| SERPINB2 \| DISEASES 7529 \| YWHAB \| DISEASES 11051 \| NUDT21 \| DISEASES 7644 \| ZNF91 \| DISEASES 94235 \| GNG8 \| DISEASES 124935 \| SLC43A2 \| DISEASES 8433 \| UTF1 \| DISEASES 171024 \| SYNPO2 \| DISEASES 51029 \| DESI2 \| DISEASES 794 \| CALB2 \| DISEASES 23592 \| LEMD3 \| DISEASES 6199 \| RPS6KB2 \| DISEASES 25992 \| SNED1 \| DISEASES 3265 \| HRAS \| DISEASES 947 \| CD34 \| DISEASES 3728 \| JUP \| DISEASES 2688 \| GH1 \| DISEASES 163 \| AP2B1 \| DISEASES 66037 \| BOLL \| DISEASES 1442 \| CSH1 \| DISEASES 90411 \| MCFD2 \| DISEASES 10808 \| HSPH1 \| DISEASES 10419 \| PRMT5 \| DISEASES 165918 \| RNF168 \| DISEASES 3640 \| INSL3 \| DISEASES 205 \| AK4 \| DISEASES 55511 \| SAGE1 \| DISEASES 6657 \| SOX2 \| DISEASES 57491 \| AHRR \| DISEASES 29122 \| PRSS50 \| DISEASES 1812 \| DRD1 \| DISEASES 1789 \| DNMT3B \| DISEASES 9074 \| CLDN6 \| DISEASES 3855 \| KRT7 \| DISEASES 4601 \| MXI1 \| DISEASES 7490 \| WT1 \| DISEASES 56001 \| NXF2 \| DISEASES 9573 \| GDF3 \| DISEASES 1485 \| CTAG1B \| DISEASES 8663 \| EIF3C \| DISEASES 2689 \| GH2 \| DISEASES 668 \| FOXL2 \| DISEASES 266740 \| MAGEA2B \| DISEASES 199720 \| GGN \| DISEASES 353324 \| SPATA12 \| DISEASES 8653 \| DDX3Y \| DISEASES 1058 \| CENPA \| DISEASES 1032 \| CDKN2D \| DISEASES 6940 \| ZNF354A \| DISEASES 56910 \| STARD7 \| DISEASES 23583 \| SMUG1 \| DISEASES 8558 \| CDK10 \| DISEASES 359787 \| DPPA3 \| DISEASES 2261 \| FGFR3 \| DISEASES 93 \| ACVR2B \| DISEASES 10755 \| GIPC1 \| DISEASES 339345 \| NANOS2 \| DISEASES 83659 \| TEKT1 \| DISEASES 342977 \| NANOS3 \| DISEASES 2100 \| ESR2 \| DISEASES 81848 \| SPRY4 \| DISEASES 26503 \| SLC17A5 \| DISEASES 419 \| ART3 \| DISEASES 5265 \| SERPINA1 \| DISEASES 7405 \| UVRAG \| DISEASES 122786 \| FRMD6 \| DISEASES 4100 \| MAGEA1 \| DISEASES 55124 \| PIWIL2 \| DISEASES 11186 \| RASSF1 \| DISEASES 2526 \| FUT4 \| DISEASES 160 \| AP2A1 \| DISEASES 7004 \| TEAD4 \| DISEASES 4133 \| MAP2 \| DISEASES 578 \| BAK1 \| DISEASES 57111 \| RAB25 \| DISEASES 51438 \| MAGEC2 \| DISEASES 54739 \| XAF1 \| DISEASES 8564 \| KMO \| DISEASES 5788 \| PTPRC \| DISEASES 356 \| FASLG \| DISEASES 7259 \| TSPYL1 \| DISEASES 639 \| PRDM1 \| DISEASES 116442 \| RAB39B \| DISEASES 6847 \| SYCP1 \| DISEASES 4102 \| MAGEA3 \| DISEASES 4101 \| MAGEA2 \| DISEASES 64648 \| SPANXD \| DISEASES 30014 \| SPANXA1 \| DISEASES 541466 \| CT45A1 \| DISEASES 51213 \| LUZP4 \| DISEASES 7422 \| VEGFA \| DISEASES 728343 \| NXF2B \| DISEASES 2516 \| NR5A1 \| DISEASES 80312 \| TET1 \| DISEASES 367 \| AR \| DISEASES 249 \| ALPL \| DISEASES 727837 \| SSX2B \| DISEASES 6392 \| SDHD \| DISEASES 728239 \| MAGED4 \| DISEASES 9371 \| KIF3B \| DISEASES 3621 \| ING1 \| DISEASES 955 \| ENTPD6 \| DISEASES 2650 \| GCNT1 \| DISEASES 3105 \| HLA-A \| DISEASES 369 \| ARAF \| DISEASES 10253 \| SPRY2 \| DISEASES 94027 \| CGB7 \| DISEASES 728577 \| CNTNAP3B \| DISEASES 1787 \| TRDMT1 \| DISEASES 4609 \| MYC \| DISEASES 768 \| CA9 \| DISEASES 123872 \| DNAAF1 \| DISEASES 5420 \| PODXL \| DISEASES 7163 \| TPD52 \| DISEASES 1832 \| DSP \| DISEASES 5884 \| RAD17 \| DISEASES 2103 \| ESRRB \| DISEASES 5214 \| PFKP \| DISEASES 2576 \| GAGE4 \| DISEASES 2543 \| GAGE1 \| DISEASES 50808 \| AK3 \| DISEASES 1761 \| DMRT1 \| DISEASES 378949 \| RBMY1D \| DISEASES 6736 \| SRY \| DISEASES 3875 \| KRT18 \| DISEASES 56254 \| RNF20 \| DISEASES 250 \| ALPP \| DISEASES 2591 \| GALNT3 \| DISEASES 6996 \| TDG \| DISEASES 1443 \| CSH2 \| DISEASES 5450 \| POU2AF1 \| DISEASES 3161 \| HMMR \| DISEASES 196410 \| METTL7B \| DISEASES 2719 \| GPC3 \| DISEASES 174 \| AFP \| DISEASES 144195 \| SLC2A14 \| DISEASES 23532 \| PRAME \| DISEASES 23414 \| ZFPM2 \| DISEASES 1617 \| DAZ1 \| DISEASES 51270 \| TFDP3 \| DISEASES 3481 \| IGF2 \| DISEASES 2674 \| GFRA1 \| DISEASES 3833 \| KIFC1 \| DISEASES 1029 \| CDKN2A \| DISEASES 7849 \| PAX8 \| DISEASES 7258 \| TSPY1 \| DISEASES 2886 \| GRB7 \| DISEASES 94115 \| CGB8 \| DISEASES 100289087 \| TSPY10 \| DISEASES 2668 \| GDNF \| DISEASES 196527 \| ANO6 \| DISEASES 3925 \| STMN1 \| DISEASES 3831 \| KLC1 \| DISEASES 645073 \| GAGE12G \| DISEASES 3483 \| IGFALS \| DISEASES 4700 \| NDUFA6 \| DISEASES 30816 \| ERVW-1 \| DISEASES 346653 \| FAM71F2 \| DISEASES 405754 \| ERVFRD-1 \| DISEASES 3295 \| HSD17B4 \| DISEASES 8649 \| LAMTOR3 \| DISEASES 54514 \| DDX4 \| DISEASES 10687 \| PNMA2 \| DISEASES 54970 \| TTC12 \| DISEASES 4190 \| MDH1 \| DISEASES 91 \| ACVR1B \| DISEASES 3939 \| LDHA \| DISEASES 317 \| APAF1 \| DISEASES 11245 \| GPR176 \| DISEASES 7732 \| RNF112 \| DISEASES 3292 \| HSD17B1 \| DISEASES 199713 \| NLRP7 \| DISEASES 732253 \| TDRG1 \| DISEASES
Locus	(Waiting for update.)

Disease ID	1029
Disease	seminoma
Integrated Phenotype	(Waiting for update.)
Text Mined Phenotype	HPO \| Name \| Sentences' Count(Total Phenotypes:20) HP:0002664 \| Neoplasia \| 17 HP:0000028 \| Cryptorchidism \| 7 HP:0030731 \| Carcinoma \| 5 HP:0009792 \| Teratoma \| 2 HP:0010788 \| Testicular neoplasm \| 2 HP:0008668 \| 46,xy gonadal dysgenesis \| 1 HP:0002729 \| Follicular hyperplasia \| 1 HP:0001409 \| Portal hypertension \| 1 HP:0001945 \| Fever \| 1 HP:0003072 \| Hypercalcemia \| 1 HP:0000133 \| Mixed gonadal dysgenesis \| 1 HP:0100242 \| Sarcoma \| 1 HP:0002383 \| Encephalitis \| 1 HP:0002835 \| Aspiration \| 1 HP:0000016 \| Urinary retention \| 1 HP:0100728 \| Germ cell neoplasia \| 1 HP:0008689 \| Bilateral cryptorchidism \| 1 HP:0010459 \| True hermaphroditism \| 1 HP:0000822 \| Hypertension \| 1 HP:0100620 \| Germinoma \| 1

Disease ID	1029
Disease	seminoma
Manually Symptom	(Waiting for update.)
Text Mined Symptom	UMLS \| Name \| Sentences' Count(Total Symptoms:4) C0205851 \| germ cell tumors \| 2 C0153685 \| renal metastasis \| 1 C0020437 \| hypercalcemia \| 1 C0030472 \| paraneoplastic syndrome \| 1

Manually Genotype(Total Text Mining Genotypes:0)
(Waiting for update.)

All Snps(Total Genotypes:5)
snpId	pubmedId	geneId	geneSymbol	diseaseId	sourceId	sentence	score	Year	geneSymbol_dbSNP	CHROMOSOME	POS	REF	ALT
rs7371084	22245602	2099	ESR1	umls:C0036631	BeFree	Polymorphisms in ESR1 (rs9397080; OR=1.85, 95% CI: 1.18-2.91) and LHCGR (rs7371084; OR=2.37, 95% CI: 1.26-4.49) associated with risk of seminoma and metastasis, respectively.	0.000542884	2012	LHCGR;STON1-GTF2A1L	2	48712814	T	C
rs7371084	22245602	3973	LHCGR	umls:C0036631	BeFree	Polymorphisms in ESR1 (rs9397080; OR=1.85, 95% CI: 1.18-2.91) and LHCGR (rs7371084; OR=2.37, 95% CI: 1.26-4.49) associated with risk of seminoma and metastasis, respectively.	0.000271442	2012	LHCGR;STON1-GTF2A1L	2	48712814	T	C
rs78311289	19855393	3265	HRAS	umls:C0036631	BeFree	Screening of 30 spermatocytic seminomas for oncogenic mutations in 17 genes identified 2 mutations in FGFR3 (both 1948A>G, encoding K650E, which causes thanatophoric dysplasia in the germline) and 5 mutations in HRAS.	0.120271442	2009	FGFR3	4	1806162	A	C,G
rs9397080	22245602	3973	LHCGR	umls:C0036631	BeFree	Polymorphisms in ESR1 (rs9397080; OR=1.85, 95% CI: 1.18-2.91) and LHCGR (rs7371084; OR=2.37, 95% CI: 1.26-4.49) associated with risk of seminoma and metastasis, respectively.	0.000271442	2012	ESR1	6	152059380	C	T
rs9397080	22245602	2099	ESR1	umls:C0036631	BeFree	Polymorphisms in ESR1 (rs9397080; OR=1.85, 95% CI: 1.18-2.91) and LHCGR (rs7371084; OR=2.37, 95% CI: 1.26-4.49) associated with risk of seminoma and metastasis, respectively.	0.000542884	2012	ESR1	6	152059380	C	T

GWASdb Annotation(Total Genotypes:0)
(Waiting for update.)

GWASdb Snp Trait(Total Genotypes:95)
CHR	POS	SNPID	REF	ALT	ORI_SNPID	PMID	P_VALUE	P_VALUE_TEXT	OR/BETA	CI95_TEXT	GWAS_INITIAL_SAMPLE_SIZE	SUB_POPULATION	SUPER_POPULATION	GWAS_TRAIT	HPO_ID	HPO_TERM	DO_ID	DO_TERM	MESH_ID	MESH_TERM	EFO_ID	EFO_TERM	DOLITE_TERM	RISK_ALLELE	PUBLICATION_TYPE	AA	GENE_SYMBOL	TYPE	REFGENE
1	156169610	rs2072499	A	G	rs2072499	23666240	3.00E-08	NA	1.19	[1.08-1.30]	986 European ancestry cases; 4,946 European ancestry controls	European(5932)	ALL(5932)	EUR(5932)	ALL(5932)	Testicular germ cell tumor	HPOID:0100617	Testicular seminoma	DOID:5557	testicular germ cell cancer	D009373	Neoplasms, Germ Cell and Embryonal	EFOID:0005088	testicular carcinoma	Testicular tumor	rs2072499-G	Meta-Analysis	Research Support, Non-U.S. Gov't	C
1	165831649	rs4657482	A	G	rs4657482	19483681	2.00E-06	NA	1.14	[0.99-1.31]	730 cases; 1,435 controls	NOPOP(2165)	ALL(2165)	NOPOP(2165)	ALL(2165)	Testicular germ cell tumor	HPOID:0100617	Testicular seminoma	DOID:5557	testicular germ cell cancer	D009373	Neoplasms, Germ Cell and Embryonal	EFOID:0005088	testicular carcinoma	Testicular tumor	rs4657482-A	Research Support, Non-U.S. Gov't	G	UCK2
1	165831649	rs4657482	A	G	rs4657482	23666239	6.00E-06	NA	1.43	[1.22-1.67]	582 European ancestry male cases; 1,056 European ancestry male controls	European(1638)	ALL(1638)	EUR(1638)	ALL(1638)	Testicular germ cell tumor	HPOID:0100617	Testicular seminoma	DOID:5557	testicular germ cell cancer	D009373	Neoplasms, Germ Cell and Embryonal	EFOID:0005088	testicular carcinoma	Testicular tumor	rs4657482-A	Research Support, N.I.H., Extramural	Meta-Analysis	Research Support, Non-U.S. Gov't
1	165873392	rs3790672	T	C	rs3790672	23666240	2.00E-08	NA	1.2	[1.09-1.33]	986 European ancestry cases; 4,946 European ancestry controls	European(5932)	ALL(5932)	EUR(5932)	ALL(5932)	Testicular germ cell tumor	HPOID:0100617	Testicular seminoma	DOID:5557	testicular germ cell cancer	D009373	Neoplasms, Germ Cell and Embryonal	EFOID:0005088	testicular carcinoma	Testicular tumor	rs3790672-C	Meta-Analysis	Research Support, Non-U.S. Gov't	T
3	16625048	rs10510452	A	G	rs10510452	23666240	1.00E-08	NA	1.24	[1.12-1.37]	986 European ancestry cases; 4,946 European ancestry controls	European(5932)	ALL(5932)	EUR(5932)	ALL(5932)	Testicular germ cell tumor	HPOID:0100617	Testicular seminoma	DOID:5557	testicular germ cell cancer	D009373	Neoplasms, Germ Cell and Embryonal	EFOID:0005088	testicular carcinoma	Testicular tumor	rs10510452-A	Meta-Analysis	Research Support, Non-U.S. Gov't	A
4	95224812	rs17021463	T	G	rs17021463	23666239	1.00E-08	NA	1.19	[1.12-1.26]	582 European ancestry male cases; 1,056 European ancestry male controls	European(1638)	ALL(1638)	EUR(1638)	ALL(1638)	Testicular germ cell tumor	HPOID:0100617	Testicular seminoma	DOID:5557	testicular germ cell cancer	D009373	Neoplasms, Germ Cell and Embryonal	EFOID:0005088	testicular carcinoma	Testicular tumor	rs17021463-T	Research Support, N.I.H., Extramural	Meta-Analysis	Research Support, Non-U.S. Gov't
4	104054686	rs2720460	A	G	rs2720460	23666240	2.00E-10	NA	1.24	[1.12-1.36]	986 European ancestry cases; 4,946 European ancestry controls	European(5932)	ALL(5932)	EUR(5932)	ALL(5932)	Testicular germ cell tumor	HPOID:0100617	Testicular seminoma	DOID:5557	testicular germ cell cancer	D009373	Neoplasms, Germ Cell and Embryonal	EFOID:0005088	testicular carcinoma	Testicular tumor	rs2720460-A	Meta-Analysis	Research Support, Non-U.S. Gov't	G
4	104137790	rs4699052	C	T	rs4699052	19483681	2.00E-07	NA	1.21	[1.05-1.39]	730 cases; 1,435 controls	NOPOP(2165)	ALL(2165)	NOPOP(2165)	ALL(2165)	Testicular germ cell tumor	HPOID:0100617	Testicular seminoma	DOID:5557	testicular germ cell cancer	D009373	Neoplasms, Germ Cell and Embryonal	EFOID:0005088	testicular carcinoma	Testicular tumor	rs4699052-C	Research Support, Non-U.S. Gov't	T	NA
5	1279790	rs10069690	C	T	rs10069690	20543847	3.71E-08	NA	NA	NA	979 European ancestry cases; 4,947 European ancestry controls	European(5926)	ALL(5926)	EUR(5926)	ALL(5926)	Testicular germ cell cancer	HPOID:0100617	Testicular seminoma	DOID:5557	testicular germ cell cancer	D013736	Testicular Neoplasms	EFOID:0005088	testicular carcinoma	Testicular tumor	NA	Research Support, Non-U.S. Gov't	T	TERT
5	1286516	rs2736100	C	A	rs2736100	20543847	8.00E-15	NA	1.33	[1.18-1.50]	979 European ancestry cases; 4,947 European ancestry controls	European(5926)	ALL(5926)	EUR(5926)	ALL(5926)	Testicular germ cell cancer	HPOID:0100617	Testicular seminoma	DOID:5557	testicular germ cell cancer	D013736	Testicular Neoplasms	EFOID:0005088	testicular carcinoma	Testicular tumor	rs2736100-T	Research Support, Non-U.S. Gov't	T	TERT
5	1286516	rs2736100	C	A	rs2736100	23666239	4.82E-05	NA	1.37	[1.77-1.58]	582 European ancestry male cases; 1,056 European ancestry male controls	European(1638)	ALL(1638)	EUR(1638)	ALL(1638)	Testicular germ cell tumor	HPOID:0100617	Testicular seminoma	DOID:5557	testicular germ cell cancer	D009373	Neoplasms, Germ Cell and Embryonal	EFOID:0005088	testicular carcinoma	Testicular tumor	rs2736100-G	Research Support, N.I.H., Extramural	Meta-Analysis	Research Support, Non-U.S. Gov't
5	1286516	rs2736100	C	A	rs2736100	23666240	6.12E-18	NA	1.32	[1.20-1.45]	986 European ancestry cases; 4,946 European ancestry controls	European(5932)	ALL(5932)	EUR(5932)	ALL(5932)	Testicular germ cell tumor	HPOID:0100617	Testicular seminoma	DOID:5557	testicular germ cell cancer	D009373	Neoplasms, Germ Cell and Embryonal	EFOID:0005088	testicular carcinoma	Testicular tumor	rs2736100-G	Meta-Analysis	Research Support, Non-U.S. Gov't	T
5	1288547	rs2853676	T	C	rs2853676	20543847	6.18E-07	NA	NA	NA	979 European ancestry cases; 4,947 European ancestry controls	European(5926)	ALL(5926)	EUR(5926)	ALL(5926)	Testicular germ cell cancer	HPOID:0100617	Testicular seminoma	DOID:5557	testicular germ cell cancer	D013736	Testicular Neoplasms	EFOID:0005088	testicular carcinoma	Testicular tumor	NA	Research Support, Non-U.S. Gov't	G	TERT
5	1294086	rs2736098	C	T	rs2736098	20543847	2.21E-06	NA	NA	NA	979 European ancestry cases; 4,947 European ancestry controls	European(5926)	ALL(5926)	EUR(5926)	ALL(5926)	Testicular germ cell cancer	HPOID:0100617	Testicular seminoma	DOID:5557	testicular germ cell cancer	D013736	Testicular Neoplasms	EFOID:0005088	testicular carcinoma	Testicular tumor	NA	Research Support, Non-U.S. Gov't	G	TERT
5	1308552	rs4635969	G	A	rs4635969	20543847	1.00E-23	NA	1.54	[1.33-1.79]	979 European ancestry cases; 4,947 European ancestry controls	European(5926)	ALL(5926)	EUR(5926)	ALL(5926)	Testicular germ cell cancer	HPOID:0100617	Testicular seminoma	DOID:5557	testicular germ cell cancer	D013736	Testicular Neoplasms	EFOID:0005088	testicular carcinoma	Testicular tumor	rs4635969-T	Research Support, Non-U.S. Gov't	C	NA
5	1308552	rs4635969	G	A	rs4635969	23666239	2.22E-04	NA	1.4	[1.17-1.68]	582 European ancestry male cases; 1,056 European ancestry male controls	European(1638)	ALL(1638)	EUR(1638)	ALL(1638)	Testicular germ cell tumor	HPOID:0100617	Testicular seminoma	DOID:5557	testicular germ cell cancer	D009373	Neoplasms, Germ Cell and Embryonal	EFOID:0005088	testicular carcinoma	Testicular tumor	rs4635969-T	Research Support, N.I.H., Extramural	Meta-Analysis	Research Support, Non-U.S. Gov't
5	1308552	rs4635969	G	A	rs4635969	23666240	5.00E-24	NA	1.39	[1.25-1.54]	986 European ancestry cases; 4,946 European ancestry controls	European(5932)	ALL(5932)	EUR(5932)	ALL(5932)	Testicular germ cell tumor	HPOID:0100617	Testicular seminoma	DOID:5557	testicular germ cell cancer	D009373	Neoplasms, Germ Cell and Embryonal	EFOID:0005088	testicular carcinoma	Testicular tumor	rs4635969-T	Meta-Analysis	Research Support, Non-U.S. Gov't	C
5	1315343	rs4975615	G	A	rs4975615	20543847	2.50E-08	NA	NA	NA	979 European ancestry cases; 4,947 European ancestry controls	European(5926)	ALL(5926)	EUR(5926)	ALL(5926)	Testicular germ cell cancer	HPOID:0100617	Testicular seminoma	DOID:5557	testicular germ cell cancer	D013736	Testicular Neoplasms	EFOID:0005088	testicular carcinoma	Testicular tumor	NA	Research Support, Non-U.S. Gov't	A	NA
5	1315660	rs4975616	G	A	rs4975616	20543847	5.91E-07	NA	NA	NA	979 European ancestry cases; 4,947 European ancestry controls	European(5926)	ALL(5926)	EUR(5926)	ALL(5926)	Testicular germ cell cancer	HPOID:0100617	Testicular seminoma	DOID:5557	testicular germ cell cancer	D013736	Testicular Neoplasms	EFOID:0005088	testicular carcinoma	Testicular tumor	NA	Research Support, Non-U.S. Gov't	G	NA
5	1319680	rs451360	C	A	rs451360	20543847	1.16E-15	NA	NA	NA	979 European ancestry cases; 4,947 European ancestry controls	European(5926)	ALL(5926)	EUR(5926)	ALL(5926)	Testicular germ cell cancer	HPOID:0100617	Testicular seminoma	DOID:5557	testicular germ cell cancer	D013736	Testicular Neoplasms	EFOID:0005088	testicular carcinoma	Testicular tumor	NA	Research Support, Non-U.S. Gov't	G	CLPTM1L
5	1320136	rs421629	G	A	rs421629	20543847	7.44E-07	NA	NA	NA	979 European ancestry cases; 4,947 European ancestry controls	European(5926)	ALL(5926)	EUR(5926)	ALL(5926)	Testicular germ cell cancer	HPOID:0100617	Testicular seminoma	DOID:5557	testicular germ cell cancer	D013736	Testicular Neoplasms	EFOID:0005088	testicular carcinoma	Testicular tumor	NA	Research Support, Non-U.S. Gov't	T	CLPTM1L
5	1320247	rs380286	G	A	rs380286	20543847	7.44E-07	NA	NA	NA	979 European ancestry cases; 4,947 European ancestry controls	European(5926)	ALL(5926)	EUR(5926)	ALL(5926)	Testicular germ cell cancer	HPOID:0100617	Testicular seminoma	DOID:5557	testicular germ cell cancer	D013736	Testicular Neoplasms	EFOID:0005088	testicular carcinoma	Testicular tumor	NA	Research Support, Non-U.S. Gov't	A	CLPTM1L
5	1322087	rs401681	C	T	rs401681	20543847	4.24E-22	NA	NA	NA	979 European ancestry cases; 4,947 European ancestry controls	European(5926)	ALL(5926)	EUR(5926)	ALL(5926)	Testicular germ cell cancer	HPOID:0100617	Testicular seminoma	DOID:5557	testicular germ cell cancer	D013736	Testicular Neoplasms	EFOID:0005088	testicular carcinoma	Testicular tumor	NA	Research Support, Non-U.S. Gov't	T	CLPTM1L
5	1325767	rs466502	A	G	rs466502	20543847	3.08E-07	NA	NA	NA	979 European ancestry cases; 4,947 European ancestry controls	European(5926)	ALL(5926)	EUR(5926)	ALL(5926)	Testicular germ cell cancer	HPOID:0100617	Testicular seminoma	DOID:5557	testicular germ cell cancer	D013736	Testicular Neoplasms	EFOID:0005088	testicular carcinoma	Testicular tumor	NA	Research Support, Non-U.S. Gov't	T	CLPTM1L
5	1325803	rs465498	A	G	rs465498	20543847	7.48E-07	NA	NA	NA	979 European ancestry cases; 4,947 European ancestry controls	European(5926)	ALL(5926)	EUR(5926)	ALL(5926)	Testicular germ cell cancer	HPOID:0100617	Testicular seminoma	DOID:5557	testicular germ cell cancer	D013736	Testicular Neoplasms	EFOID:0005088	testicular carcinoma	Testicular tumor	NA	Research Support, Non-U.S. Gov't	C	CLPTM1L
5	1330253	rs452932	T	C	rs452932	20543847	7.44E-07	NA	NA	NA	979 European ancestry cases; 4,947 European ancestry controls	European(5926)	ALL(5926)	EUR(5926)	ALL(5926)	Testicular germ cell cancer	HPOID:0100617	Testicular seminoma	DOID:5557	testicular germ cell cancer	D013736	Testicular Neoplasms	EFOID:0005088	testicular carcinoma	Testicular tumor	NA	Research Support, Non-U.S. Gov't	G	CLPTM1L
5	1330840	rs452384	T	C	rs452384	20543847	7.48E-07	NA	NA	NA	979 European ancestry cases; 4,947 European ancestry controls	European(5926)	ALL(5926)	EUR(5926)	ALL(5926)	Testicular germ cell cancer	HPOID:0100617	Testicular seminoma	DOID:5557	testicular germ cell cancer	D013736	Testicular Neoplasms	EFOID:0005088	testicular carcinoma	Testicular tumor	NA	Research Support, Non-U.S. Gov't	G	CLPTM1L
5	1336221	rs467095	T	C	rs467095	20543847	7.49E-07	NA	NA	NA	979 European ancestry cases; 4,947 European ancestry controls	European(5926)	ALL(5926)	EUR(5926)	ALL(5926)	Testicular germ cell cancer	HPOID:0100617	Testicular seminoma	DOID:5557	testicular germ cell cancer	D013736	Testicular Neoplasms	EFOID:0005088	testicular carcinoma	Testicular tumor	NA	Research Support, Non-U.S. Gov't	G	CLPTM1L
5	1337906	rs31484	A	T	rs31484	20543847	7.48E-07	NA	NA	NA	979 European ancestry cases; 4,947 European ancestry controls	European(5926)	ALL(5926)	EUR(5926)	ALL(5926)	Testicular germ cell cancer	HPOID:0100617	Testicular seminoma	DOID:5557	testicular germ cell cancer	D013736	Testicular Neoplasms	EFOID:0005088	testicular carcinoma	Testicular tumor	NA	Research Support, Non-U.S. Gov't	T	CLPTM1L
5	1342714	rs31489	C	A	rs31489	20543847	3.27E-08	NA	NA	NA	979 European ancestry cases; 4,947 European ancestry controls	European(5926)	ALL(5926)	EUR(5926)	ALL(5926)	Testicular germ cell cancer	HPOID:0100617	Testicular seminoma	DOID:5557	testicular germ cell cancer	D013736	Testicular Neoplasms	EFOID:0005088	testicular carcinoma	Testicular tumor	NA	Research Support, Non-U.S. Gov't	C	CLPTM1L
5	1344458	rs31490	G	A	rs31490	20543847	3.05E-07	NA	NA	NA	979 European ancestry cases; 4,947 European ancestry controls	European(5926)	ALL(5926)	EUR(5926)	ALL(5926)	Testicular germ cell cancer	HPOID:0100617	Testicular seminoma	DOID:5557	testicular germ cell cancer	D013736	Testicular Neoplasms	EFOID:0005088	testicular carcinoma	Testicular tumor	NA	Research Support, Non-U.S. Gov't	G	CLPTM1L
5	1346303	rs27070	G	C	rs27070	20543847	8.03E-09	NA	NA	NA	979 European ancestry cases; 4,947 European ancestry controls	European(5926)	ALL(5926)	EUR(5926)	ALL(5926)	Testicular germ cell cancer	HPOID:0100617	Testicular seminoma	DOID:5557	testicular germ cell cancer	D013736	Testicular Neoplasms	EFOID:0005088	testicular carcinoma	Testicular tumor	NA	Research Support, Non-U.S. Gov't	A	NA
5	134366200	rs3805663	A	G	rs3805663	23666240	2.00E-08	NA	1.25	[1.13-1.38]	986 European ancestry cases; 4,946 European ancestry controls	European(5932)	ALL(5932)	EUR(5932)	ALL(5932)	Testicular germ cell tumor	HPOID:0100617	Testicular seminoma	DOID:5557	testicular germ cell cancer	D009373	Neoplasms, Germ Cell and Embryonal	EFOID:0005088	testicular carcinoma	Testicular tumor	rs3805663-T	Meta-Analysis	Research Support, Non-U.S. Gov't	G
5	141656556	rs11167772	T	C	rs11167772	20543847	1.50E-11	NA	NA	NA	979 European ancestry cases; 4,947 European ancestry controls	European(5926)	ALL(5926)	EUR(5926)	ALL(5926)	Testicular germ cell cancer	HPOID:0100617	Testicular seminoma	DOID:5557	testicular germ cell cancer	D013736	Testicular Neoplasms	EFOID:0005088	testicular carcinoma	Testicular tumor	NA	Research Support, Non-U.S. Gov't	C	NA
5	141660464	rs4912837	C	T	rs4912837	20543847	6.79E-13	NA	NA	NA	979 European ancestry cases; 4,947 European ancestry controls	European(5926)	ALL(5926)	EUR(5926)	ALL(5926)	Testicular germ cell cancer	HPOID:0100617	Testicular seminoma	DOID:5557	testicular germ cell cancer	D013736	Testicular Neoplasms	EFOID:0005088	testicular carcinoma	Testicular tumor	NA	Research Support, Non-U.S. Gov't	C	NA
5	141669507	rs4324715	C	T	rs4324715	23666239	1.42E-07	NA	1.59	[1.33-1.89]	582 European ancestry male cases; 1,056 European ancestry male controls	European(1638)	ALL(1638)	EUR(1638)	ALL(1638)	Testicular germ cell tumor	HPOID:0100617	Testicular seminoma	DOID:5557	testicular germ cell cancer	D009373	Neoplasms, Germ Cell and Embryonal	EFOID:0005088	testicular carcinoma	Testicular tumor	rs4324715-C	Research Support, N.I.H., Extramural	Meta-Analysis	Research Support, Non-U.S. Gov't
5	141681788	rs4624820	G	A	rs4624820	19483681	3.00E-13	NA	1.37	[1.19-1.58]	730 cases; 1,435 controls	NOPOP(2165)	ALL(2165)	NOPOP(2165)	ALL(2165)	Testicular germ cell tumor	HPOID:0100617	Testicular seminoma	DOID:5557	testicular germ cell cancer	D009373	Neoplasms, Germ Cell and Embryonal	EFOID:0005088	testicular carcinoma	Testicular tumor	rs4624820-A	Research Support, Non-U.S. Gov't	G	NA
5	141681788	rs4624820	G	A	rs4624820	20543847	1.00E-14	NA	1.47	[1.33-1.64]	979 European ancestry cases; 4,947 European ancestry controls	European(5926)	ALL(5926)	EUR(5926)	ALL(5926)	Testicular germ cell cancer	HPOID:0100617	Testicular seminoma	DOID:5557	testicular germ cell cancer	D013736	Testicular Neoplasms	EFOID:0005088	testicular carcinoma	Testicular tumor	NA	Research Support, Non-U.S. Gov't	G	NA
5	141681788	rs4624820	G	A	rs4624820	23666239	8.00E-10	NA	1.64	[1.39-1.89]	582 European ancestry male cases; 1,056 European ancestry male controls	European(1638)	ALL(1638)	EUR(1638)	ALL(1638)	Testicular germ cell tumor	HPOID:0100617	Testicular seminoma	DOID:5557	testicular germ cell cancer	D009373	Neoplasms, Germ Cell and Embryonal	EFOID:0005088	testicular carcinoma	Testicular tumor	rs4624820-G	Research Support, N.I.H., Extramural	Meta-Analysis	Research Support, Non-U.S. Gov't
5	141681788	rs4624820	G	A	rs4624820	23666240	3.00E-31	NA	1.52	[1.38-1.67]	986 European ancestry cases; 4,946 European ancestry controls	European(5932)	ALL(5932)	EUR(5932)	ALL(5932)	Testicular germ cell tumor	HPOID:0100617	Testicular seminoma	DOID:5557	testicular germ cell cancer	D009373	Neoplasms, Germ Cell and Embryonal	EFOID:0005088	testicular carcinoma	Testicular tumor	rs4624820-A	Meta-Analysis	Research Support, Non-U.S. Gov't	G
5	141707606	rs959662	A	G	rs959662	20543847	4.97E-08	NA	NA	NA	979 European ancestry cases; 4,947 European ancestry controls	European(5926)	ALL(5926)	EUR(5926)	ALL(5926)	Testicular germ cell cancer	HPOID:0100617	Testicular seminoma	DOID:5557	testicular germ cell cancer	D013736	Testicular Neoplasms	EFOID:0005088	testicular carcinoma	Testicular tumor	NA	Research Support, Non-U.S. Gov't	A	NA
6	33541719	rs513349	A	G	rs513349	20543847	1.16E-08	NA	NA	NA	979 European ancestry cases; 4,947 European ancestry controls	European(5926)	ALL(5926)	EUR(5926)	ALL(5926)	Testicular germ cell cancer	HPOID:0100617	Testicular seminoma	DOID:5557	testicular germ cell cancer	D013736	Testicular Neoplasms	EFOID:0005088	testicular carcinoma	Testicular tumor	NA	Research Support, Non-U.S. Gov't	G	BAK1
6	33542538	rs210138	A	G	rs210138	19483681	1.00E-13	NA	1.5	[1.28-1.75]	730 cases; 1,435 controls	NOPOP(2165)	ALL(2165)	NOPOP(2165)	ALL(2165)	Testicular germ cell tumor	HPOID:0100617	Testicular seminoma	DOID:5557	testicular germ cell cancer	D009373	Neoplasms, Germ Cell and Embryonal	EFOID:0005088	testicular carcinoma	Testicular tumor	rs210138-G	Research Support, Non-U.S. Gov't	G	BAK1
6	33542538	rs210138	A	G	rs210138	20543847	3.77E-12	NA	NA	NA	979 European ancestry cases; 4,947 European ancestry controls	European(5926)	ALL(5926)	EUR(5926)	ALL(5926)	Testicular germ cell cancer	HPOID:0100617	Testicular seminoma	DOID:5557	testicular germ cell cancer	D013736	Testicular Neoplasms	EFOID:0005088	testicular carcinoma	Testicular tumor	NA	Research Support, Non-U.S. Gov't	G	BAK1
6	33542538	rs210138	A	G	rs210138	23666239	3.00E-07	NA	1.62	[1.35-1.95]	582 European ancestry male cases; 1,056 European ancestry male controls	European(1638)	ALL(1638)	EUR(1638)	ALL(1638)	Testicular germ cell tumor	HPOID:0100617	Testicular seminoma	DOID:5557	testicular germ cell cancer	D009373	Neoplasms, Germ Cell and Embryonal	EFOID:0005088	testicular carcinoma	Testicular tumor	rs210138-G	Research Support, N.I.H., Extramural	Meta-Analysis	Research Support, Non-U.S. Gov't
6	33542538	rs210138	A	G	rs210138	23666240	2.00E-24	NA	1.44	[1.30-1.61]	986 European ancestry cases; 4,946 European ancestry controls	European(5932)	ALL(5932)	EUR(5932)	ALL(5932)	Testicular germ cell tumor	HPOID:0100617	Testicular seminoma	DOID:5557	testicular germ cell cancer	D009373	Neoplasms, Germ Cell and Embryonal	EFOID:0005088	testicular carcinoma	Testicular tumor	rs210138-G	Meta-Analysis	Research Support, Non-U.S. Gov't	G
6	33543409	rs210139	A	C	rs210139	20543847	2.80E-14	NA	NA	NA	979 European ancestry cases; 4,947 European ancestry controls	European(5926)	ALL(5926)	EUR(5926)	ALL(5926)	Testicular germ cell cancer	HPOID:0100617	Testicular seminoma	DOID:5557	testicular germ cell cancer	D013736	Testicular Neoplasms	EFOID:0005088	testicular carcinoma	Testicular tumor	NA	Research Support, Non-U.S. Gov't	A	BAK1
6	33557741	rs375555	T	C	rs375555	20543847	1.94E-12	NA	NA	NA	979 European ancestry cases; 4,947 European ancestry controls	European(5926)	ALL(5926)	EUR(5926)	ALL(5926)	Testicular germ cell cancer	HPOID:0100617	Testicular seminoma	DOID:5557	testicular germ cell cancer	D013736	Testicular Neoplasms	EFOID:0005088	testicular carcinoma	Testicular tumor	NA	Research Support, Non-U.S. Gov't	T	LINC00336
6	33606523	rs4713646	C	T	rs4713646	20543847	2.41E-12	NA	NA	NA	979 European ancestry cases; 4,947 European ancestry controls	European(5926)	ALL(5926)	EUR(5926)	ALL(5926)	Testicular germ cell cancer	HPOID:0100617	Testicular seminoma	DOID:5557	testicular germ cell cancer	D013736	Testicular Neoplasms	EFOID:0005088	testicular carcinoma	Testicular tumor	NA	Research Support, Non-U.S. Gov't	C,T	ITPR3
6	144446518	rs7760281	T	C	rs7760281	23666239	7.98E-04	NA	1.12	[1.05-1.19]	582 European ancestry male cases; 1,056 European ancestry male controls	European(1638)	ALL(1638)	EUR(1638)	ALL(1638)	Testicular germ cell tumor	HPOID:0100617	Testicular seminoma	DOID:5557	testicular germ cell cancer	D009373	Neoplasms, Germ Cell and Embryonal	EFOID:0005088	testicular carcinoma	Testicular tumor	rs7760281-	Research Support, N.I.H., Extramural	Meta-Analysis	Research Support, Non-U.S. Gov't
7	1920826	rs10275045	C	T	rs10275045	23666239	3.78E-10	NA	1.2	[1.13-1.27]	582 European ancestry male cases; 1,056 European ancestry male controls	European(1638)	ALL(1638)	EUR(1638)	ALL(1638)	Testicular germ cell tumor	HPOID:0100617	Testicular seminoma	DOID:5557	testicular germ cell cancer	D009373	Neoplasms, Germ Cell and Embryonal	EFOID:0005088	testicular carcinoma	Testicular tumor	NA	Research Support, N.I.H., Extramural	Meta-Analysis	Research Support, Non-U.S. Gov't
7	1968953	rs12699477	T	C	rs12699477	23666239	6.00E-09	NA	1.21	[1.14-1.29]	582 European ancestry male cases; 1,056 European ancestry male controls	European(1638)	ALL(1638)	EUR(1638)	ALL(1638)	Testicular germ cell tumor	HPOID:0100617	Testicular seminoma	DOID:5557	testicular germ cell cancer	D009373	Neoplasms, Germ Cell and Embryonal	EFOID:0005088	testicular carcinoma	Testicular tumor	rs12699477-C	Research Support, N.I.H., Extramural	Meta-Analysis	Research Support, Non-U.S. Gov't
7	2172455	rs3778991	G	A	rs3778991	23666239	6.73E-10	NA	1.21	[1.14-1.28]	582 European ancestry male cases; 1,056 European ancestry male controls	European(1638)	ALL(1638)	EUR(1638)	ALL(1638)	Testicular germ cell tumor	HPOID:0100617	Testicular seminoma	DOID:5557	testicular germ cell cancer	D009373	Neoplasms, Germ Cell and Embryonal	EFOID:0005088	testicular carcinoma	Testicular tumor	rs3778991-	Research Support, N.I.H., Extramural	Meta-Analysis	Research Support, Non-U.S. Gov't
8	70976505	rs7010162	C	T	rs7010162	23666240	5.00E-08	NA	1.22	[1.11-1.34]	986 European ancestry cases; 4,946 European ancestry controls	European(5932)	ALL(5932)	EUR(5932)	ALL(5932)	Testicular germ cell tumor	HPOID:0100617	Testicular seminoma	DOID:5557	testicular germ cell cancer	D009373	Neoplasms, Germ Cell and Embryonal	EFOID:0005088	testicular carcinoma	Testicular tumor	rs7010162-G	Meta-Analysis	Research Support, Non-U.S. Gov't	C
9	802801	rs2370200	A	G	rs2370200	20543847	7.91E-08	NA	NA	NA	979 European ancestry cases; 4,947 European ancestry controls	European(5926)	ALL(5926)	EUR(5926)	ALL(5926)	Testicular germ cell cancer	HPOID:0100617	Testicular seminoma	DOID:5557	testicular germ cell cancer	D013736	Testicular Neoplasms	EFOID:0005088	testicular carcinoma	Testicular tumor	NA	Research Support, Non-U.S. Gov't	A	NA
9	804436	rs4742419	T	C	rs4742419	20543847	2.78E-07	NA	NA	NA	979 European ancestry cases; 4,947 European ancestry controls	European(5926)	ALL(5926)	EUR(5926)	ALL(5926)	Testicular germ cell cancer	HPOID:0100617	Testicular seminoma	DOID:5557	testicular germ cell cancer	D013736	Testicular Neoplasms	EFOID:0005088	testicular carcinoma	Testicular tumor	NA	Research Support, Non-U.S. Gov't	T,C	NA
9	818693	rs10815756	T	C	rs10815756	20543847	3.05E-08	NA	NA	NA	979 European ancestry cases; 4,947 European ancestry controls	European(5926)	ALL(5926)	EUR(5926)	ALL(5926)	Testicular germ cell cancer	HPOID:0100617	Testicular seminoma	DOID:5557	testicular germ cell cancer	D013736	Testicular Neoplasms	EFOID:0005088	testicular carcinoma	Testicular tumor	NA	Research Support, Non-U.S. Gov't	T	NA
9	822594	rs4141756	T	C	rs4141756	20543847	2.08E-09	NA	NA	NA	979 European ancestry cases; 4,947 European ancestry controls	European(5926)	ALL(5926)	EUR(5926)	ALL(5926)	Testicular germ cell cancer	HPOID:0100617	Testicular seminoma	DOID:5557	testicular germ cell cancer	D013736	Testicular Neoplasms	EFOID:0005088	testicular carcinoma	Testicular tumor	NA	Research Support, Non-U.S. Gov't	T	NA
9	855091	rs7029148	A	G	rs7029148	20543847	1.48E-09	NA	NA	NA	979 European ancestry cases; 4,947 European ancestry controls	European(5926)	ALL(5926)	EUR(5926)	ALL(5926)	Testicular germ cell cancer	HPOID:0100617	Testicular seminoma	DOID:5557	testicular germ cell cancer	D013736	Testicular Neoplasms	EFOID:0005088	testicular carcinoma	Testicular tumor	NA	Research Support, Non-U.S. Gov't	A	DMRT1
9	863635	rs755383	C	T	rs755383	20543847	1.00E-23	NA	1.37	[1.21-1.55]	979 European ancestry cases; 4,947 European ancestry controls	European(5926)	ALL(5926)	EUR(5926)	ALL(5926)	Testicular germ cell cancer	HPOID:0100617	Testicular seminoma	DOID:5557	testicular germ cell cancer	D013736	Testicular Neoplasms	EFOID:0005088	testicular carcinoma	Testicular tumor	rs755383-T	Research Support, Non-U.S. Gov't	C	DMRT1
9	863635	rs755383	C	T	rs755383	23666239	4.00E-07	NA	1.52	[1.30-1.79]	582 European ancestry male cases; 1,056 European ancestry male controls	European(1638)	ALL(1638)	EUR(1638)	ALL(1638)	Testicular germ cell tumor	HPOID:0100617	Testicular seminoma	DOID:5557	testicular germ cell cancer	D009373	Neoplasms, Germ Cell and Embryonal	EFOID:0005088	testicular carcinoma	Testicular tumor	rs755383-C	Research Support, N.I.H., Extramural	Meta-Analysis	Research Support, Non-U.S. Gov't
9	863635	rs755383	C	T	rs755383	23666240	2.00E-26	NA	1.38	[1.25-1.52]	986 European ancestry cases; 4,946 European ancestry controls	European(5932)	ALL(5932)	EUR(5932)	ALL(5932)	Testicular germ cell tumor	HPOID:0100617	Testicular seminoma	DOID:5557	testicular germ cell cancer	D009373	Neoplasms, Germ Cell and Embryonal	EFOID:0005088	testicular carcinoma	Testicular tumor	rs755383-T	Meta-Analysis	Research Support, Non-U.S. Gov't	C
12	14628069	rs4346018	A	G	rs4346018	20543847	3.20E-19	NA	NA	NA	979 European ancestry cases; 4,947 European ancestry controls	European(5926)	ALL(5926)	EUR(5926)	ALL(5926)	Testicular germ cell cancer	HPOID:0100617	Testicular seminoma	DOID:5557	testicular germ cell cancer	D013736	Testicular Neoplasms	EFOID:0005088	testicular carcinoma	Testicular tumor	NA	Research Support, Non-U.S. Gov't	A	ATF7IP
12	14653867	rs2900333	C	T	rs2900333	20543847	6.00E-10	NA	1.27	[1.12-1.44]	979 European ancestry cases; 4,947 European ancestry controls	European(5926)	ALL(5926)	EUR(5926)	ALL(5926)	Testicular germ cell cancer	HPOID:0100617	Testicular seminoma	DOID:5557	testicular germ cell cancer	D013736	Testicular Neoplasms	EFOID:0005088	testicular carcinoma	Testicular tumor	rs2900333-C	Research Support, Non-U.S. Gov't	C	NA
12	14653867	rs2900333	C	T	rs2900333	23666240	1.00E-13	NA	1.32	[1.20-1.46]	986 European ancestry cases; 4,946 European ancestry controls	European(5932)	ALL(5932)	EUR(5932)	ALL(5932)	Testicular germ cell tumor	HPOID:0100617	Testicular seminoma	DOID:5557	testicular germ cell cancer	D009373	Neoplasms, Germ Cell and Embryonal	EFOID:0005088	testicular carcinoma	Testicular tumor	rs2900333-C	Meta-Analysis	Research Support, Non-U.S. Gov't	C
12	88732585	rs4842602	C	T	rs4842602	20543847	9.43E-07	NA	NA	NA	979 European ancestry cases; 4,947 European ancestry controls	European(5926)	ALL(5926)	EUR(5926)	ALL(5926)	Testicular germ cell cancer	HPOID:0100617	Testicular seminoma	DOID:5557	testicular germ cell cancer	D013736	Testicular Neoplasms	EFOID:0005088	testicular carcinoma	Testicular tumor	NA	Research Support, Non-U.S. Gov't	C	NA
12	88811689	rs4842610	C	T	rs4842610	20543847	8.23E-10	NA	NA	NA	979 European ancestry cases; 4,947 European ancestry controls	European(5926)	ALL(5926)	EUR(5926)	ALL(5926)	Testicular germ cell cancer	HPOID:0100617	Testicular seminoma	DOID:5557	testicular germ cell cancer	D013736	Testicular Neoplasms	EFOID:0005088	testicular carcinoma	Testicular tumor	NA	Research Support, Non-U.S. Gov't	C	NA
12	88848006	rs7974506	A	G	rs7974506	20543847	7.18E-08	NA	NA	NA	979 European ancestry cases; 4,947 European ancestry controls	European(5926)	ALL(5926)	EUR(5926)	ALL(5926)	Testicular germ cell cancer	HPOID:0100617	Testicular seminoma	DOID:5557	testicular germ cell cancer	D013736	Testicular Neoplasms	EFOID:0005088	testicular carcinoma	Testicular tumor	NA	Research Support, Non-U.S. Gov't	G	NA
12	88865241	rs11104896	T	C	rs11104896	20543847	6.88E-07	NA	NA	NA	979 European ancestry cases; 4,947 European ancestry controls	European(5926)	ALL(5926)	EUR(5926)	ALL(5926)	Testicular germ cell cancer	HPOID:0100617	Testicular seminoma	DOID:5557	testicular germ cell cancer	D013736	Testicular Neoplasms	EFOID:0005088	testicular carcinoma	Testicular tumor	NA	Research Support, Non-U.S. Gov't	C	NA
12	88874179	rs11104901	G	T	rs11104901	20543847	2.31E-13	NA	NA	NA	979 European ancestry cases; 4,947 European ancestry controls	European(5926)	ALL(5926)	EUR(5926)	ALL(5926)	Testicular germ cell cancer	HPOID:0100617	Testicular seminoma	DOID:5557	testicular germ cell cancer	D013736	Testicular Neoplasms	EFOID:0005088	testicular carcinoma	Testicular tumor	NA	Research Support, Non-U.S. Gov't	C	NA
12	88890671	rs995030	A	G	rs995030	19483681	1.00E-31	NA	2.55	[2.05-3.19]	730 cases; 1,435 controls	NOPOP(2165)	ALL(2165)	NOPOP(2165)	ALL(2165)	Testicular germ cell tumor	HPOID:0100617	Testicular seminoma	DOID:5557	testicular germ cell cancer	D009373	Neoplasms, Germ Cell and Embryonal	EFOID:0005088	testicular carcinoma	Testicular tumor	rs1508595-G	Research Support, Non-U.S. Gov't	A	KITLG
12	88890671	rs995030	A	G	rs995030	19483681	3.00E-30	NA	2.69	[2.10-3.44]	730 cases; 1,435 controls	NOPOP(2165)	ALL(2165)	NOPOP(2165)	ALL(2165)	Testicular germ cell tumor	HPOID:0100617	Testicular seminoma	DOID:5557	testicular germ cell cancer	D009373	Neoplasms, Germ Cell and Embryonal	EFOID:0005088	testicular carcinoma	Testicular tumor	rs1508595-G	Research Support, Non-U.S. Gov't	A	KITLG
12	88890671	rs995030	A	G	rs995030	20543847	2.65E-12	NA	NA	NA	979 European ancestry cases; 4,947 European ancestry controls	European(5926)	ALL(5926)	EUR(5926)	ALL(5926)	Testicular germ cell cancer	HPOID:0100617	Testicular seminoma	DOID:5557	testicular germ cell cancer	D013736	Testicular Neoplasms	EFOID:0005088	testicular carcinoma	Testicular tumor	NA	Research Support, Non-U.S. Gov't	A	KITLG
12	88890671	rs995030	A	G	rs995030	23666239	3.00E-13	NA	2.33	[1.85-2.94]	582 European ancestry male cases; 1,056 European ancestry male controls	European(1638)	ALL(1638)	EUR(1638)	ALL(1638)	Testicular germ cell tumor	HPOID:0100617	Testicular seminoma	DOID:5557	testicular germ cell cancer	D009373	Neoplasms, Germ Cell and Embryonal	EFOID:0005088	testicular carcinoma	Testicular tumor	rs995030-A	Research Support, N.I.H., Extramural	Meta-Analysis	Research Support, Non-U.S. Gov't
12	88890671	rs995030	A	G	rs995030	23666240	2.00E-50	NA	2.26	[1.95-2.61]	986 European ancestry cases; 4,946 European ancestry controls	European(5932)	ALL(5932)	EUR(5932)	ALL(5932)	Testicular germ cell tumor	HPOID:0100617	Testicular seminoma	DOID:5557	testicular germ cell cancer	D009373	Neoplasms, Germ Cell and Embryonal	EFOID:0005088	testicular carcinoma	Testicular tumor	rs995030-G	Meta-Analysis	Research Support, Non-U.S. Gov't	A
12	88904764	rs11104911	C	T	rs11104911	20543847	8.85E-25	NA	NA	NA	979 European ancestry cases; 4,947 European ancestry controls	European(5926)	ALL(5926)	EUR(5926)	ALL(5926)	Testicular germ cell cancer	HPOID:0100617	Testicular seminoma	DOID:5557	testicular germ cell cancer	D013736	Testicular Neoplasms	EFOID:0005088	testicular carcinoma	Testicular tumor	NA	Research Support, Non-U.S. Gov't	T	KITLG
12	88915835	rs10777125	G	A	rs10777125	20543847	6.66E-13	NA	NA	NA	979 European ancestry cases; 4,947 European ancestry controls	European(5926)	ALL(5926)	EUR(5926)	ALL(5926)	Testicular germ cell cancer	HPOID:0100617	Testicular seminoma	DOID:5557	testicular germ cell cancer	D013736	Testicular Neoplasms	EFOID:0005088	testicular carcinoma	Testicular tumor	NA	Research Support, Non-U.S. Gov't	A	KITLG
12	88918743	rs1022034	T	G	rs1022034	20543847	4.13E-11	NA	NA	NA	979 European ancestry cases; 4,947 European ancestry controls	European(5926)	ALL(5926)	EUR(5926)	ALL(5926)	Testicular germ cell cancer	HPOID:0100617	Testicular seminoma	DOID:5557	testicular germ cell cancer	D013736	Testicular Neoplasms	EFOID:0005088	testicular carcinoma	Testicular tumor	NA	Research Support, Non-U.S. Gov't	A	KITLG
12	88925973	rs1492347	T	C	rs1492347	20543847	2.29E-24	NA	NA	NA	979 European ancestry cases; 4,947 European ancestry controls	European(5926)	ALL(5926)	EUR(5926)	ALL(5926)	Testicular germ cell cancer	HPOID:0100617	Testicular seminoma	DOID:5557	testicular germ cell cancer	D013736	Testicular Neoplasms	EFOID:0005088	testicular carcinoma	Testicular tumor	NA	Research Support, Non-U.S. Gov't	C	KITLG
12	88932035	rs10506956	C	A	rs10506956	20543847	1.24E-10	NA	NA	NA	979 European ancestry cases; 4,947 European ancestry controls	European(5926)	ALL(5926)	EUR(5926)	ALL(5926)	Testicular germ cell cancer	HPOID:0100617	Testicular seminoma	DOID:5557	testicular germ cell cancer	D013736	Testicular Neoplasms	EFOID:0005088	testicular carcinoma	Testicular tumor	NA	Research Support, Non-U.S. Gov't	A	KITLG
12	88939133	rs3782176	A	G	rs3782176	20543847	1.29E-12	NA	NA	NA	979 European ancestry cases; 4,947 European ancestry controls	European(5926)	ALL(5926)	EUR(5926)	ALL(5926)	Testicular germ cell cancer	HPOID:0100617	Testicular seminoma	DOID:5557	testicular germ cell cancer	D013736	Testicular Neoplasms	EFOID:0005088	testicular carcinoma	Testicular tumor	NA	Research Support, Non-U.S. Gov't	G	KITLG
12	88953561	rs3782181	C	A	rs3782181	20543847	2.00E-26	NA	2.22	[1.89-2.56]	979 European ancestry cases; 4,947 European ancestry controls	European(5926)	ALL(5926)	EUR(5926)	ALL(5926)	Testicular germ cell cancer	HPOID:0100617	Testicular seminoma	DOID:5557	testicular germ cell cancer	D013736	Testicular Neoplasms	EFOID:0005088	testicular carcinoma	Testicular tumor	NA	Research Support, Non-U.S. Gov't	C	KITLG
12	88986016	rs1508595	G	A	rs1508595	20543847	1.81E-26	NA	NA	NA	979 European ancestry cases; 4,947 European ancestry controls	European(5926)	ALL(5926)	EUR(5926)	ALL(5926)	Testicular germ cell cancer	HPOID:0100617	Testicular seminoma	DOID:5557	testicular germ cell cancer	D013736	Testicular Neoplasms	EFOID:0005088	testicular carcinoma	Testicular tumor	NA	Research Support, Non-U.S. Gov't	C	NA
12	88986016	rs1508595	G	A	rs1508595	23666239	1.29E-10	NA	2.38	[1.85-3.03]	582 European ancestry male cases; 1,056 European ancestry male controls	European(1638)	ALL(1638)	EUR(1638)	ALL(1638)	Testicular germ cell tumor	HPOID:0100617	Testicular seminoma	DOID:5557	testicular germ cell cancer	D009373	Neoplasms, Germ Cell and Embryonal	EFOID:0005088	testicular carcinoma	Testicular tumor	rs1508595-T	Research Support, N.I.H., Extramural	Meta-Analysis	Research Support, Non-U.S. Gov't
12	88986016	rs1508595	G	A	rs1508595	23666240	4.91E-46	NA	2.44	[2.07-2.88]	986 European ancestry cases; 4,946 European ancestry controls	European(5932)	ALL(5932)	EUR(5932)	ALL(5932)	Testicular germ cell tumor	HPOID:0100617	Testicular seminoma	DOID:5557	testicular germ cell cancer	D009373	Neoplasms, Germ Cell and Embryonal	EFOID:0005088	testicular carcinoma	Testicular tumor	rs1508595-G	Meta-Analysis	Research Support, Non-U.S. Gov't	C
16	50028105	rs7204293	G	A	rs7204293	23666239	1.42E-05	NA	1.28	[1.15-1.45]	582 European ancestry male cases; 1,056 European ancestry male controls	European(1638)	ALL(1638)	EUR(1638)	ALL(1638)	Testicular germ cell tumor	HPOID:0100617	Testicular seminoma	DOID:5557	testicular germ cell cancer	D009373	Neoplasms, Germ Cell and Embryonal	EFOID:0005088	testicular carcinoma	Testicular tumor	rs7204293-	Research Support, N.I.H., Extramural	Meta-Analysis	Research Support, Non-U.S. Gov't
16	50142944	rs8046148	A	G	rs8046148	23666239	3.00E-06	NA	1.2	[1.11-1.30]	582 European ancestry male cases; 1,056 European ancestry male controls	European(1638)	ALL(1638)	EUR(1638)	ALL(1638)	Testicular germ cell tumor	HPOID:0100617	Testicular seminoma	DOID:5557	testicular germ cell cancer	D009373	Neoplasms, Germ Cell and Embryonal	EFOID:0005088	testicular carcinoma	Testicular tumor	NA	Research Support, N.I.H., Extramural	Meta-Analysis	Research Support, Non-U.S. Gov't
16	50142944	rs8046148	A	G	rs8046148	23666240	4.00E-09	NA	1.32	[1.17-1.48]	986 European ancestry cases; 4,946 European ancestry controls	European(5932)	ALL(5932)	EUR(5932)	ALL(5932)	Testicular germ cell tumor	HPOID:0100617	Testicular seminoma	DOID:5557	testicular germ cell cancer	D009373	Neoplasms, Germ Cell and Embryonal	EFOID:0005088	testicular carcinoma	Testicular tumor	rs8046148-G	Meta-Analysis	Research Support, Non-U.S. Gov't	G
16	74670458	rs4888262	C	T	rs4888262	23666239	5.00E-12	NA	1.26	[1.18-1.34]	582 European ancestry male cases; 1,056 European ancestry male controls	European(1638)	ALL(1638)	EUR(1638)	ALL(1638)	Testicular germ cell tumor	HPOID:0100617	Testicular seminoma	DOID:5557	testicular germ cell cancer	D009373	Neoplasms, Germ Cell and Embryonal	EFOID:0005088	testicular carcinoma	Testicular tumor	rs4888262-C	Research Support, N.I.H., Extramural	Meta-Analysis	Research Support, Non-U.S. Gov't
17	56632543	rs9905704	G	T	rs9905704	23666239	4.00E-13	NA	1.27	[1.18-1.33]	582 European ancestry male cases; 1,056 European ancestry male controls	European(1638)	ALL(1638)	EUR(1638)	ALL(1638)	Testicular germ cell tumor	HPOID:0100617	Testicular seminoma	DOID:5557	testicular germ cell cancer	D009373	Neoplasms, Germ Cell and Embryonal	EFOID:0005088	testicular carcinoma	Testicular tumor	rs9905704-T	Research Support, N.I.H., Extramural	Meta-Analysis	Research Support, Non-U.S. Gov't
17	56632543	rs9905704	G	T	rs9905704	23666240	3.00E-09	NA	1.21	[1.10-1.34]	986 European ancestry cases; 4,946 European ancestry controls	European(5932)	ALL(5932)	EUR(5932)	ALL(5932)	Testicular germ cell tumor	HPOID:0100617	Testicular seminoma	DOID:5557	testicular germ cell cancer	D009373	Neoplasms, Germ Cell and Embryonal	EFOID:0005088	testicular carcinoma	Testicular tumor	rs9905704-T	Meta-Analysis	Research Support, Non-U.S. Gov't	T
17	56656624	rs1267543	A	G	rs1267543	23666239	5.05E-07	NA	1.22	[1.12-1.31]	582 European ancestry male cases; 1,056 European ancestry male controls	European(1638)	ALL(1638)	EUR(1638)	ALL(1638)	Testicular germ cell tumor	HPOID:0100617	Testicular seminoma	DOID:5557	testicular germ cell cancer	D009373	Neoplasms, Germ Cell and Embryonal	EFOID:0005088	testicular carcinoma	Testicular tumor	rs1267543-	Research Support, N.I.H., Extramural	Meta-Analysis	Research Support, Non-U.S. Gov't
17	57008128	rs7221274	A	G	rs7221274	23666239	4.04E-09	NA	1.2	[1.12-1.28]	582 European ancestry male cases; 1,056 European ancestry male controls	European(1638)	ALL(1638)	EUR(1638)	ALL(1638)	Testicular germ cell tumor	HPOID:0100617	Testicular seminoma	DOID:5557	testicular germ cell cancer	D009373	Neoplasms, Germ Cell and Embryonal	EFOID:0005088	testicular carcinoma	Testicular tumor	rs7221274-A	Research Support, N.I.H., Extramural	Meta-Analysis	Research Support, Non-U.S. Gov't
18	47109693	rs9951026	G	A	rs9951026	23666239	5.00E-06	NA	1.22	[1.12-1.33]	582 European ancestry male cases; 1,056 European ancestry male controls	European(1638)	ALL(1638)	EUR(1638)	ALL(1638)	Testicular germ cell tumor	HPOID:0100617	Testicular seminoma	DOID:5557	testicular germ cell cancer	D009373	Neoplasms, Germ Cell and Embryonal	EFOID:0005088	testicular carcinoma	Testicular tumor	NA	Research Support, N.I.H., Extramural	Meta-Analysis	Research Support, Non-U.S. Gov't
21	47690068	rs2839186	C	T	rs2839186	23666240	1.00E-09	NA	1.26	[1.15-1.38]	986 European ancestry cases; 4,946 European ancestry controls	European(5932)	ALL(5932)	EUR(5932)	ALL(5932)	Testicular germ cell tumor	HPOID:0100617	Testicular seminoma	DOID:5557	testicular germ cell cancer	D009373	Neoplasms, Germ Cell and Embryonal	EFOID:0005088	testicular carcinoma	Testicular tumor	rs2839186-T	Meta-Analysis	Research Support, Non-U.S. Gov't	T

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