PedAM

Pediatric Disease Annotations & Medicines


	secretory meningioma

Disease ID	1110
Disease	secretory meningioma
Definition	A relatively common neoplasm of the CENTRAL NERVOUS SYSTEM that arises from arachnoidal cells. The majority are well differentiated vascular tumors which grow slowly and have a low potential to be invasive, although malignant subtypes occur. Meningiomas have a predilection to arise from the parasagittal region, cerebral convexity, sphenoidal ridge, olfactory groove, and SPINAL CANAL. (From DeVita et al., Cancer: Principles and Practice of Oncology, 5th ed, pp2056-7)
Synonym	[m]meningioma nos [m]meningioma nos (disorder) [m]meningioma nos (morphologic abnormality) [m]meningiomas [m]meningiomas (morphologic abnormality) brain meningioma tumors brain tumor, meningioma endothelioma, dural fibroblastoma, arachnoidal fibroblastoma, meningeal intracranial neoplasm, meningioma leptomeningioma lymphoplasmacyte-rich meningioma meligioma mengioma mengiomia menigiom menigioma meningioma meningioma (disorder) meningioma [disease/finding] meningioma brain tumor meningioma, nos meningiomas
Orphanet	ORPHANET:2495
DOID	DOID:3565 DOID:4588 DOID:4591
UMLS	C0025286
MeSH	D008579
Curated Gene	Entrez_id \| Symbol \| Resource(Total Genes:12) AKT1 \| 207 \| CTD_human NF2 \| 4771 \| CLINVAR;CTD_human SMO \| 6608 \| CTD_human PTEN \| 5728 \| CLINVAR;CTD_human CST3 \| 1471 \| CTD_human MLLT10 \| 8028 \| CTD_human;GWASCAT CSTB \| 1476 \| CTD_human PDGFB \| 5155 \| CLINVAR ALAD \| 210 \| CTD_human HES1 \| 3280 \| CTD_human CTSL \| 1514 \| CTD_human PGR \| 5241 \| CTD_human
Inferring Gene	Entrez_id \| Symbol \| Resource(Total Genes:16) 595 \| CCND1 \| infer 999 \| CDH1 \| infer 1029 \| CDKN2A \| infer 2068 \| ERCC2 \| infer 3105 \| HLA-A \| infer 3119 \| HLA-DQB1 \| infer 3123 \| HLA-DRB1 \| infer 3845 \| KRAS \| infer 8028 \| MLLT10 \| infer 4771 \| NF2 \| infer 5728 \| PTEN \| infer 7040 \| TGFB1 \| infer 7048 \| TGFBR2 \| infer 7515 \| XRCC1 \| infer 7517 \| XRCC3 \| infer 7520 \| XRCC5 \| infer
Text Mined Gene	Entrez_id \| Symbol \| Score \| Resource(Total Genes:348) 2928 \| GSC2 \| DISEASES 54474 \| KRT20 \| DISEASES 6480 \| ST6GAL1 \| DISEASES 2099 \| ESR1 \| DISEASES 55644 \| OSGEP \| DISEASES 10633 \| RASL10A \| DISEASES 1113 \| CHGA \| DISEASES 10857 \| PGRMC1 \| DISEASES 7076 \| TIMP1 \| DISEASES 6445 \| SGCG \| DISEASES 4313 \| MMP2 \| DISEASES 1428 \| CRYM \| DISEASES 29106 \| SCG3 \| DISEASES 6422 \| SFRP1 \| DISEASES 973 \| CD79A \| DISEASES 973 \| CD79A \| DISEASES 1048 \| CEACAM5 \| DISEASES 1048 \| CEACAM5 \| DISEASES 3082 \| HGF \| DISEASES 3203 \| HOXA6 \| DISEASES 7431 \| VIM \| DISEASES 6198 \| RPS6KB1 \| DISEASES 708 \| C1QBP \| DISEASES 27346 \| TMEM97 \| DISEASES 595 \| CCND1 \| DISEASES 4254 \| KITLG \| DISEASES 2026 \| ENO2 \| DISEASES 6206 \| RPS12 \| DISEASES 55754 \| TMEM30A \| DISEASES 6678 \| SPARC \| DISEASES 4820 \| NKTR \| DISEASES 7475 \| WNT6 \| DISEASES 7799 \| PRDM2 \| DISEASES 1509 \| CTSD \| DISEASES 6718 \| AKR1D1 \| DISEASES 4109 \| MAGEA10 \| DISEASES 88745 \| RRP36 \| DISEASES 83473 \| KATNAL2 \| DISEASES 23002 \| DAAM1 \| DISEASES 2952 \| GSTT1 \| DISEASES 7533 \| YWHAH \| DISEASES 2781 \| GNAZ \| DISEASES 64101 \| LRRC4 \| DISEASES 10776 \| ARPP19 \| DISEASES 968 \| CD68 \| DISEASES 968 \| CD68 \| DISEASES 79603 \| CERS4 \| DISEASES 4142 \| MAS1 \| DISEASES 2670 \| GFAP \| DISEASES 51659 \| GINS2 \| DISEASES 3958 \| LGALS3 \| DISEASES 3958 \| LGALS3 \| DISEASES 6382 \| SDC1 \| DISEASES 8932 \| MBD2 \| DISEASES 10752 \| CHL1 \| DISEASES 2947 \| GSTM3 \| DISEASES 2346 \| FOLH1 \| DISEASES 29109 \| FHOD1 \| DISEASES 1144 \| CHRND \| DISEASES 7111 \| TMOD1 \| DISEASES 85462 \| FHDC1 \| DISEASES 51050 \| PI15 \| DISEASES 7450 \| VWF \| DISEASES 57534 \| MIB1 \| DISEASES 57534 \| MIB1 \| DISEASES 999 \| CDH1 \| DISEASES 3340 \| NDST1 \| DISEASES 5159 \| PDGFRB \| DISEASES 2196 \| FAT2 \| DISEASES 114294 \| LACTB \| DISEASES 6132 \| RPL8 \| DISEASES 1031 \| CDKN2C \| DISEASES 7011 \| TEP1 \| DISEASES 7077 \| TIMP2 \| DISEASES 25939 \| SAMHD1 \| DISEASES 7515 \| XRCC1 \| DISEASES 7089 \| TLE2 \| DISEASES 1801 \| DPH1 \| DISEASES 9609 \| RAB36 \| DISEASES 6598 \| SMARCB1 \| DISEASES 6855 \| SYP \| DISEASES 7299 \| TYR \| DISEASES 10000 \| AKT3 \| DISEASES 3791 \| KDR \| DISEASES 5290 \| PIK3CA \| DISEASES 5290 \| PIK3CA \| DISEASES 8452 \| CUL3 \| DISEASES 119 \| ADD2 \| DISEASES 2247 \| FGF2 \| DISEASES 6774 \| STAT3 \| DISEASES 4552 \| MTRR \| DISEASES 5443 \| POMC \| DISEASES 1950 \| EGF \| DISEASES 10371 \| SEMA3A \| DISEASES 8829 \| NRP1 \| DISEASES 7078 \| TIMP3 \| DISEASES 85416 \| ZIC5 \| DISEASES 6751 \| SSTR1 \| DISEASES 79798 \| ARMC5 \| DISEASES 7157 \| TP53 \| DISEASES 2064 \| ERBB2 \| DISEASES 56006 \| SMG9 \| DISEASES 207 \| AKT1 \| DISEASES 963 \| CD53 \| DISEASES 23500 \| DAAM2 \| DISEASES 1956 \| EGFR \| DISEASES 7013 \| TERF1 \| DISEASES 1030 \| CDKN2B \| DISEASES 4851 \| NOTCH1 \| DISEASES 726 \| CAPN5 \| DISEASES 4253 \| CTAGE5 \| DISEASES 4613 \| MYCN \| DISEASES 57544 \| TXNDC16 \| DISEASES 8404 \| SPARCL1 \| DISEASES 7545 \| ZIC1 \| DISEASES 1070 \| CETN3 \| DISEASES 7345 \| UCHL1 \| DISEASES 57188 \| ADAMTSL3 \| DISEASES 6750 \| SST \| DISEASES 3815 \| KIT \| DISEASES 114793 \| FMNL2 \| DISEASES 1476 \| CSTB \| DISEASES 6285 \| S100B \| DISEASES 3856 \| KRT8 \| DISEASES 6755 \| SSTR5 \| DISEASES 886 \| CCKAR \| DISEASES 3490 \| IGFBP7 \| DISEASES 84315 \| MON1A \| DISEASES 65268 \| WNK2 \| DISEASES 57447 \| NDRG2 \| DISEASES 9317 \| PTER \| DISEASES 4665 \| NAB2 \| DISEASES 6778 \| STAT6 \| DISEASES 4255 \| MGMT \| DISEASES 5617 \| PRL \| DISEASES 5604 \| MAP2K1 \| DISEASES 3479 \| IGF1 \| DISEASES 23440 \| OTP \| DISEASES 7324 \| UBE2E1 \| DISEASES 171558 \| PTCRA \| DISEASES 4330 \| MN1 \| DISEASES 23450 \| SF3B3 \| DISEASES 8507 \| ENC1 \| DISEASES 51029 \| DESI2 \| DISEASES 23627 \| PRND \| DISEASES 4176 \| MCM7 \| DISEASES 8028 \| MLLT10 \| DISEASES 794 \| CALB2 \| DISEASES 5340 \| PLG \| DISEASES 7015 \| TERT \| DISEASES 3265 \| HRAS \| DISEASES 29127 \| RACGAP1 \| DISEASES 947 \| CD34 \| DISEASES 836 \| CASP3 \| DISEASES 358 \| AQP1 \| DISEASES 641371 \| ACOT1 \| DISEASES 2944 \| GSTM1 \| DISEASES 64236 \| PDLIM2 \| DISEASES 150368 \| FAM109B \| DISEASES 55885 \| LMO3 \| DISEASES 2824 \| GPM6B \| DISEASES 4684 \| NCAM1 \| DISEASES 56776 \| FMN2 \| DISEASES 84231 \| TRAF7 \| DISEASES 84231 \| TRAF7 \| DISEASES 1730 \| DIAPH2 \| DISEASES 348825 \| TPRXL \| DISEASES 3039 \| HBA1 \| DISEASES 6605 \| SMARCE1 \| DISEASES 3200 \| HOXA3 \| DISEASES 55553 \| SOX6 \| DISEASES 5241 \| PGR \| DISEASES 5241 \| PGR \| DISEASES 3735 \| KARS \| DISEASES 121227 \| LRIG3 \| DISEASES 706 \| TSPO \| DISEASES 64764 \| CREB3L2 \| DISEASES 752 \| FMNL1 \| DISEASES 3855 \| KRT7 \| DISEASES 3855 \| KRT7 \| DISEASES 440822 \| PIWIL3 \| DISEASES 6753 \| SSTR3 \| DISEASES 2894 \| GRID1 \| DISEASES 5155 \| PDGFB \| DISEASES 10196 \| PRMT3 \| DISEASES 5727 \| PTCH1 \| DISEASES 2301 \| FOXE3 \| DISEASES 23760 \| PITPNB \| DISEASES 2306 \| FOXD2 \| DISEASES 887 \| CCKBR \| DISEASES 91010 \| FMNL3 \| DISEASES 4221 \| MEN1 \| DISEASES 1641 \| DCX \| DISEASES 23583 \| SMUG1 \| DISEASES 7430 \| EZR \| DISEASES 5329 \| PLAUR \| DISEASES 10612 \| TRIM3 \| DISEASES 375056 \| MIA3 \| DISEASES 113675 \| SDSL \| DISEASES 23136 \| EPB41L3 \| DISEASES 1508 \| CTSB \| DISEASES 5962 \| RDX \| DISEASES 7517 \| XRCC3 \| DISEASES 1809 \| DPYSL3 \| DISEASES 5549 \| PRELP \| DISEASES 10634 \| GAS2L1 \| DISEASES 1499 \| CTNNB1 \| DISEASES 4771 \| NF2 \| DISEASES 4771 \| NF2 \| DISEASES 2035 \| EPB41 \| DISEASES 6146 \| RPL22 \| DISEASES 5154 \| PDGFA \| DISEASES 65267 \| WNK3 \| DISEASES 7080 \| NKX2-1 \| DISEASES 22872 \| SEC31A \| DISEASES 4983 \| OPHN1 \| DISEASES 161291 \| TMEM30B \| DISEASES 2073 \| ERCC5 \| DISEASES 5265 \| SERPINA1 \| DISEASES 10438 \| C1D \| DISEASES 6898 \| TAT \| DISEASES 10142 \| AKAP9 \| DISEASES 3841 \| KPNA5 \| DISEASES 11065 \| UBE2C \| DISEASES 6711 \| SPTBN1 \| DISEASES 6752 \| SSTR2 \| DISEASES 162 \| AP1B1 \| DISEASES 23224 \| SYNE2 \| DISEASES 54879 \| ST7L \| DISEASES 79366 \| HMGN5 \| DISEASES 4763 \| NF1 \| DISEASES 2526 \| FUT4 \| DISEASES 2526 \| FUT4 \| DISEASES 51454 \| GULP1 \| DISEASES 9332 \| CD163 \| DISEASES 9332 \| CD163 \| DISEASES 4151 \| MB \| DISEASES 6693 \| SPN \| DISEASES 2157 \| F8 \| DISEASES 4478 \| MSN \| DISEASES 6663 \| SOX10 \| DISEASES 7003 \| TEAD1 \| DISEASES 51438 \| MAGEC2 \| DISEASES 57692 \| MAGEE1 \| DISEASES 9860 \| LRIG2 \| DISEASES 84288 \| EFCAB2 \| DISEASES 4548 \| MTR \| DISEASES 11221 \| DUSP10 \| DISEASES 1063 \| CENPF \| DISEASES 3664 \| IRF6 \| DISEASES 1378 \| CR1 \| DISEASES 1380 \| CR2 \| DISEASES 5788 \| PTPRC \| DISEASES 3075 \| CFH \| DISEASES 5743 \| PTGS2 \| DISEASES 10763 \| NES \| DISEASES 2173 \| FABP7 \| DISEASES 6276 \| S100A5 \| DISEASES 1520 \| CTSS \| DISEASES 7482 \| WNT2B \| DISEASES 9446 \| GSTO1 \| DISEASES 51684 \| SUFU \| DISEASES 1069 \| CETN2 \| DISEASES 4102 \| MAGEA3 \| DISEASES 10023 \| FRAT1 \| DISEASES 5236 \| PGM1 \| DISEASES 5236 \| PGM1 \| DISEASES 5730 \| PTGDS \| DISEASES 51213 \| LUZP4 \| DISEASES 5728 \| PTEN \| DISEASES 8438 \| RAD54L \| DISEASES 7422 \| VEGFA \| DISEASES 8471 \| IRS4 \| DISEASES 4318 \| MMP9 \| DISEASES 7417 \| VDAC2 \| DISEASES 5328 \| PLAU \| DISEASES 2022 \| ENG \| DISEASES 7321 \| UBE2D1 \| DISEASES 282966 \| C10orf53 \| DISEASES 9314 \| KLF4 \| DISEASES 9314 \| KLF4 \| DISEASES 249 \| ALPL \| DISEASES 728239 \| MAGED4 \| DISEASES 1164 \| CKS2 \| DISEASES 4524 \| MTHFR \| DISEASES 10590 \| SCGN \| DISEASES 4609 \| MYC \| DISEASES 7161 \| TP73 \| DISEASES 768 \| CA9 \| DISEASES 7498 \| XDH \| DISEASES 1832 \| DSP \| DISEASES 10087 \| COL4A3BP \| DISEASES 25975 \| EGFL6 \| DISEASES 1045 \| CDX2 \| DISEASES 4267 \| CD99 \| DISEASES 2315 \| MLANA \| DISEASES 5555 \| PRH2 \| DISEASES 143 \| PARP4 \| DISEASES 51244 \| CCDC174 \| DISEASES 2068 \| ERCC2 \| DISEASES 9047 \| SH2D2A \| DISEASES 9244 \| CRLF1 \| DISEASES 2113 \| ETS1 \| DISEASES 12 \| SERPINA3 \| DISEASES 5803 \| PTPRZ1 \| DISEASES 65009 \| NDRG4 \| DISEASES 126549 \| ANKLE1 \| DISEASES 51474 \| LIMA1 \| DISEASES 6696 \| SPP1 \| DISEASES 831 \| CAST \| DISEASES 29998 \| GLTSCR1 \| DISEASES 8563 \| THOC5 \| DISEASES 23331 \| TTC28 \| DISEASES 2950 \| GSTP1 \| DISEASES 81624 \| DIAPH3 \| DISEASES 5970 \| RELA \| DISEASES 210 \| ALAD \| DISEASES 6336 \| SCN10A \| DISEASES 3481 \| IGF2 \| DISEASES 57224 \| NHSL1 \| DISEASES 1029 \| CDKN2A \| DISEASES 23705 \| CADM1 \| DISEASES 55683 \| KANSL3 \| DISEASES 392862 \| GRID2IP \| DISEASES 8848 \| TSC22D1 \| DISEASES 960 \| CD44 \| DISEASES 2130 \| EWSR1 \| DISEASES 29970 \| SCHIP1 \| DISEASES 5554 \| PRH1 \| DISEASES 6628 \| SNRPB \| DISEASES 4583 \| MUC2 \| DISEASES 8842 \| PROM1 \| DISEASES 6513 \| SLC2A1 \| DISEASES 8314 \| BAP1 \| DISEASES 4193 \| MDM2 \| DISEASES 6168 \| RPL37A \| DISEASES 573 \| BAG1 \| DISEASES 5164 \| PDK2 \| DISEASES 84107 \| ZIC4 \| DISEASES 169355 \| IDO2 \| DISEASES 8218 \| CLTCL1 \| DISEASES 7090 \| TLE3 \| DISEASES 401207 \| C5orf63 \| DISEASES 81033 \| KCNH6 \| DISEASES 9063 \| PIAS2 \| DISEASES 102723508 \| KANTR \| DISEASES 400866 \| LINC00114 \| DISEASES 692217 \| SNORD114@ \| DISEASES
Locus	(Waiting for update.)

Disease ID	1110
Disease	secretory meningioma
Integrated Phenotype	(Waiting for update.)
Text Mined Phenotype	(Waiting for update.)

Disease ID	1110
Disease	secretory meningioma
Manually Symptom	(Waiting for update.)
Text Mined Symptom	(Waiting for update.)

Manually Genotype(Total Text Mining Genotypes:0)
(Waiting for update.)

All Snps(Total Genotypes:51)
snpId	pubmedId	geneId	geneSymbol	diseaseId	sourceId	sentence	score	Year	geneSymbol_dbSNP	CHROMOSOME	POS	REF	ALT
rs10203061	20406964	10438	C1D	umls:C0025286	GAD	[Our results indicate that common genetic polymorphisms in innate immunity genes may be associated with risk of meningioma.]	0.002367032	2010	C1D	2	68054627	A	G
rs1035938	20150366	29998	GLTSCR1	umls:C0025286	BeFree	We observed significantly increased risk of meningioma with the T variant of GLTSCR1 rs1035938 (OR(CT/TT) = 3.5; 95% confidence interval: 1.8-6.9; P(trend) .0006), which persisted after controlling for multiple comparisons (P = .019).	0.002638474	2010	GLTSCR1	19	47680514	C	T
rs1045485	18823701	841	CASP8	umls:C0025286	BeFree	CASP8 D302H and meningioma risk: an analysis of five case-control series.	0.005634266	2009	CASP8	2	201284866	G	C
rs10503360	20406964	1670	DEFA5	umls:C0025286	GAD	[Seventeen SNPs distributed across 12 genetic regions (NFKB1 (3), FCER1G (3), CCR6 (2), VCAM1, CD14, TNFRSF18, RAC2, XDH, C1D, TLR1/TLR10/TLR6, NOS1, and DEFA5) were associated with the risk of meningioma with P<0.01.]	0.002638474	2010	NA	8	7050533	T	G,A
rs1056836	16598069	1545	CYP1B1	umls:C0025286	BeFree	The CYP1B1 V432L homozygous variant was associated with decreased risk of meningioma (odds ratio [OR] = 0.6; 95% CI, 0.3-1.0) but not the other tumor types.	0.000271442	2006	CYP1B1	2	38071060	G	C
rs10850803	20406964	4842	NOS1	umls:C0025286	GAD	[Seventeen SNPs distributed across 12 genetic regions (NFKB1 (3), FCER1G (3), CCR6 (2), VCAM1, CD14, TNFRSF18, RAC2, XDH, C1D, TLR1/TLR10/TLR6, NOS1, and DEFA5) were associated with the risk of meningioma with P<0.01.]	0.002638474	2010	NOS1	12	117244024	A	G
rs11012732	21804547	8028	MLLT10	umls:C0025286	GWASCAT	Common variation at 10p12.31 near MLLT10 influences meningioma risk.	0.242909916	2011	MLLT10	10	21541175	A	G
rs11012732	21804547	8028	MLLT10	umls:C0025286	GAD	[Common variation at 10p12.31 near MLLT10 influences meningioma risk.]	0.242909916	2011	MLLT10	10	21541175	A	G
rs11466657	20406964	7096	TLR1	umls:C0025286	GAD	[Seventeen SNPs distributed across 12 genetic regions (NFKB1 (3), FCER1G (3), CCR6 (2), VCAM1, CD14, TNFRSF18, RAC2, XDH, C1D, TLR1/TLR10/TLR6, NOS1, and DEFA5) were associated with the risk of meningioma with P<0.01.]	0.002367032	2010	TLR10	4	38774173	A	G
rs12094497	20406964	2207	FCER1G	umls:C0025286	GAD	[Seventeen SNPs distributed across 12 genetic regions (NFKB1 (3), FCER1G (3), CCR6 (2), VCAM1, CD14, TNFRSF18, RAC2, XDH, C1D, TLR1/TLR10/TLR6, NOS1, and DEFA5) were associated with the risk of meningioma with P<0.01.]	0.002638474	2010	FCER1G	1	161216513	G	A
rs121434259	NA	4771	NF2	umls:C0025286	CLINVAR	NA	0.298870175	NA	NF2	22	29636805	C	T
rs121909235	NA	5728	PTEN	umls:C0025286	CLINVAR	NA	0.245819831	NA	PTEN	10	87957919	G	A
rs12770228	24755950	8028	MLLT10	umls:C0025286	BeFree	The variant 'A' allele in MLLT10 rs12770228 was associated with an increased risk of meningioma (per allele odds ratio: 1.25; 95% confidence interval: 1.02, 1.53; P=0.031).	0.242909916	2014	CASC10	10	21494705	G	A
rs17655	23534771	7515	XRCC1	umls:C0025286	BeFree	In conclusion, our study has shown that XRCC1 Gln399Arg, XRCC1 Arg194Trp, XRCC3 Thr241Met and ERCC5 Asp1558His are associated with risk of gliomas and meningiomas.	0.00764398	2013	ERCC5;BIVM-ERCC5	13	102875652	G	C
rs17655	23534771	7517	XRCC3	umls:C0025286	BeFree	In conclusion, our study has shown that XRCC1 Gln399Arg, XRCC1 Arg194Trp, XRCC3 Thr241Met and ERCC5 Asp1558His are associated with risk of gliomas and meningiomas.	0.00764398	2013	ERCC5;BIVM-ERCC5	13	102875652	G	C
rs17655	23534771	2073	ERCC5	umls:C0025286	BeFree	In conclusion, our study has shown that XRCC1 Gln399Arg, XRCC1 Arg194Trp, XRCC3 Thr241Met and ERCC5 Asp1558His are associated with risk of gliomas and meningiomas.	0.002638474	2013	ERCC5;BIVM-ERCC5	13	102875652	G	C
rs1799782	23534771	7517	XRCC3	umls:C0025286	BeFree	In conclusion, our study has shown that XRCC1 Gln399Arg, XRCC1 Arg194Trp, XRCC3 Thr241Met and ERCC5 Asp1558His are associated with risk of gliomas and meningiomas.	0.00764398	2013	XRCC1	19	43553422	G	A
rs1799782	23534771	2073	ERCC5	umls:C0025286	BeFree	In conclusion, our study has shown that XRCC1 Gln399Arg, XRCC1 Arg194Trp, XRCC3 Thr241Met and ERCC5 Asp1558His are associated with risk of gliomas and meningiomas.	0.002638474	2013	XRCC1	19	43553422	G	A
rs1799782	23534771	7515	XRCC1	umls:C0025286	BeFree	In conclusion, our study has shown that XRCC1 Gln399Arg, XRCC1 Arg194Trp, XRCC3 Thr241Met and ERCC5 Asp1558His are associated with risk of gliomas and meningiomas.	0.00764398	2013	XRCC1	19	43553422	G	A
rs1800067	20150366	2072	ERCC4	umls:C0025286	BeFree	Significantly increased meningioma risk was also observed for the minor allele variants of ERCC4 rs1800067 (P(trend) .01); MUTYH rs3219466 (P(trend) .02), and PCNA rs25406 (P(trend) .03).	0.002638474	2010	ERCC4	16	13935176	G	A
rs1800067	20150366	5111	PCNA	umls:C0025286	BeFree	Significantly increased meningioma risk was also observed for the minor allele variants of ERCC4 rs1800067 (P(trend) .01); MUTYH rs3219466 (P(trend) .02), and PCNA rs25406 (P(trend) .03).	0.003452799	2010	ERCC4	16	13935176	G	A
rs1800067	20150366	4595	MUTYH	umls:C0025286	BeFree	Significantly increased meningioma risk was also observed for the minor allele variants of ERCC4 rs1800067 (P(trend) .01); MUTYH rs3219466 (P(trend) .02), and PCNA rs25406 (P(trend) .03).	0.002638474	2010	ERCC4	16	13935176	G	A
rs1805794	20150366	4683	NBN	umls:C0025286	BeFree	The NBN rs1805794 minor allele variant was associated with decreased meningioma risk (P(trend) .006).	0.002638474	2010	NBN	8	89978251	C	G
rs207444	20406964	7498	XDH	umls:C0025286	GAD	[Seventeen SNPs distributed across 12 genetic regions (NFKB1 (3), FCER1G (3), CCR6 (2), VCAM1, CD14, TNFRSF18, RAC2, XDH, C1D, TLR1/TLR10/TLR6, NOS1, and DEFA5) were associated with the risk of meningioma with P<0.01.]	0.002638474	2010	XDH	2	31340931	A	G
rs2209627	20406964	7412	VCAM1	umls:C0025286	GAD	[Seventeen SNPs distributed across 12 genetic regions (NFKB1 (3), FCER1G (3), CCR6 (2), VCAM1, CD14, TNFRSF18, RAC2, XDH, C1D, TLR1/TLR10/TLR6, NOS1, and DEFA5) were associated with the risk of meningioma with P<0.01.]	0.002367032	2010	VCAM1	1	100733591	A	G
rs2213430	20406964	5880	RAC2	umls:C0025286	GAD	[Seventeen SNPs distributed across 12 genetic regions (NFKB1 (3), FCER1G (3), CCR6 (2), VCAM1, CD14, TNFRSF18, RAC2, XDH, C1D, TLR1/TLR10/TLR6, NOS1, and DEFA5) were associated with the risk of meningioma with P<0.01.]	0.002367032	2010	RAC2	22	37242920	T	C
rs25406	20150366	4595	MUTYH	umls:C0025286	BeFree	Significantly increased meningioma risk was also observed for the minor allele variants of ERCC4 rs1800067 (P(trend) .01); MUTYH rs3219466 (P(trend) .02), and PCNA rs25406 (P(trend) .03).	0.002638474	2010	PCNA;PCNA-AS1	20	5118990	G	A
rs25406	20150366	2072	ERCC4	umls:C0025286	BeFree	Significantly increased meningioma risk was also observed for the minor allele variants of ERCC4 rs1800067 (P(trend) .01); MUTYH rs3219466 (P(trend) .02), and PCNA rs25406 (P(trend) .03).	0.002638474	2010	PCNA;PCNA-AS1	20	5118990	G	A
rs25406	20150366	5111	PCNA	umls:C0025286	BeFree	Significantly increased meningioma risk was also observed for the minor allele variants of ERCC4 rs1800067 (P(trend) .01); MUTYH rs3219466 (P(trend) .02), and PCNA rs25406 (P(trend) .03).	0.003452799	2010	PCNA;PCNA-AS1	20	5118990	G	A
rs25487	23534771	2073	ERCC5	umls:C0025286	BeFree	In conclusion, our study has shown that XRCC1 Gln399Arg, XRCC1 Arg194Trp, XRCC3 Thr241Met and ERCC5 Asp1558His are associated with risk of gliomas and meningiomas.	0.002638474	2013	XRCC1	19	43551574	T	C
rs25487	23534771	7517	XRCC3	umls:C0025286	BeFree	In conclusion, our study has shown that XRCC1 Gln399Arg, XRCC1 Arg194Trp, XRCC3 Thr241Met and ERCC5 Asp1558His are associated with risk of gliomas and meningiomas.	0.00764398	2013	XRCC1	19	43551574	T	C
rs25487	23534771	7515	XRCC1	umls:C0025286	BeFree	In conclusion, our study has shown that XRCC1 Gln399Arg, XRCC1 Arg194Trp, XRCC3 Thr241Met and ERCC5 Asp1558His are associated with risk of gliomas and meningiomas.	0.00764398	2013	XRCC1	19	43551574	T	C
rs3219466	20150366	5111	PCNA	umls:C0025286	BeFree	Significantly increased meningioma risk was also observed for the minor allele variants of ERCC4 rs1800067 (P(trend) .01); MUTYH rs3219466 (P(trend) .02), and PCNA rs25406 (P(trend) .03).	0.003452799	2010	MUTYH;TOE1	1	45340381	G	T,A
rs3219466	20150366	4595	MUTYH	umls:C0025286	BeFree	Significantly increased meningioma risk was also observed for the minor allele variants of ERCC4 rs1800067 (P(trend) .01); MUTYH rs3219466 (P(trend) .02), and PCNA rs25406 (P(trend) .03).	0.002638474	2010	MUTYH;TOE1	1	45340381	G	T,A
rs3219466	20150366	2072	ERCC4	umls:C0025286	BeFree	Significantly increased meningioma risk was also observed for the minor allele variants of ERCC4 rs1800067 (P(trend) .01); MUTYH rs3219466 (P(trend) .02), and PCNA rs25406 (P(trend) .03).	0.002638474	2010	MUTYH;TOE1	1	45340381	G	T,A
rs3822356	20406964	929	CD14	umls:C0025286	GAD	[Seventeen SNPs distributed across 12 genetic regions (NFKB1 (3), FCER1G (3), CCR6 (2), VCAM1, CD14, TNFRSF18, RAC2, XDH, C1D, TLR1/TLR10/TLR6, NOS1, and DEFA5) were associated with the risk of meningioma with P<0.01.]	0.002367032	2010	TMCO6	5	140642851	A	G
rs386493716	23534771	2073	ERCC5	umls:C0025286	BeFree	In conclusion, our study has shown that XRCC1 Gln399Arg, XRCC1 Arg194Trp, XRCC3 Thr241Met and ERCC5 Asp1558His are associated with risk of gliomas and meningiomas.	0.002638474	2013	NA	NA	NA	NA	NA
rs386493716	23534771	7515	XRCC1	umls:C0025286	BeFree	In conclusion, our study has shown that XRCC1 Gln399Arg, XRCC1 Arg194Trp, XRCC3 Thr241Met and ERCC5 Asp1558His are associated with risk of gliomas and meningiomas.	0.00764398	2013	NA	NA	NA	NA	NA
rs386493716	23534771	7517	XRCC3	umls:C0025286	BeFree	In conclusion, our study has shown that XRCC1 Gln399Arg, XRCC1 Arg194Trp, XRCC3 Thr241Met and ERCC5 Asp1558His are associated with risk of gliomas and meningiomas.	0.00764398	2013	NA	NA	NA	NA	NA
rs386545546	23534771	7517	XRCC3	umls:C0025286	BeFree	In conclusion, our study has shown that XRCC1 Gln399Arg, XRCC1 Arg194Trp, XRCC3 Thr241Met and ERCC5 Asp1558His are associated with risk of gliomas and meningiomas.	0.00764398	2013	NA	NA	NA	NA	NA
rs386545546	23534771	7515	XRCC1	umls:C0025286	BeFree	In conclusion, our study has shown that XRCC1 Gln399Arg, XRCC1 Arg194Trp, XRCC3 Thr241Met and ERCC5 Asp1558His are associated with risk of gliomas and meningiomas.	0.00764398	2013	NA	NA	NA	NA	NA
rs386545546	23534771	2073	ERCC5	umls:C0025286	BeFree	In conclusion, our study has shown that XRCC1 Gln399Arg, XRCC1 Arg194Trp, XRCC3 Thr241Met and ERCC5 Asp1558His are associated with risk of gliomas and meningiomas.	0.002638474	2013	NA	NA	NA	NA	NA
rs4656993	20406964	4720	NDUFS2	umls:C0025286	GAD	[Our results indicate that common genetic polymorphisms in innate immunity genes may be associated with risk of meningioma.]	0.002367032	2010	NDUFS2	1	161206347	A	G
rs587776563	NA	4771	NF2	umls:C0025286	CLINVAR	NA	0.298870175	NA	NF2	22	29668442	A	-
rs7574920	19505917	7498	XDH	umls:C0025286	BeFree	Furthermore, the same GPX1 polymorphisms and XDH rs7574920 were found to significantly modify the association between cumulative lead exposure and meningioma.	0.002638474	2009	XDH	2	31362783	G	C
rs7574920	19505917	2876	GPX1	umls:C0025286	BeFree	Furthermore, the same GPX1 polymorphisms and XDH rs7574920 were found to significantly modify the association between cumulative lead exposure and meningioma.	0.000271442	2009	XDH	2	31362783	G	C
rs861539	23534771	7517	XRCC3	umls:C0025286	BeFree	In conclusion, our study has shown that XRCC1 Gln399Arg, XRCC1 Arg194Trp, XRCC3 Thr241Met and ERCC5 Asp1558His are associated with risk of gliomas and meningiomas.	0.00764398	2013	KLC1;XRCC3	14	103699416	G	A
rs861539	23534771	2073	ERCC5	umls:C0025286	BeFree	In conclusion, our study has shown that XRCC1 Gln399Arg, XRCC1 Arg194Trp, XRCC3 Thr241Met and ERCC5 Asp1558His are associated with risk of gliomas and meningiomas.	0.002638474	2013	KLC1;XRCC3	14	103699416	G	A
rs861539	23534771	7515	XRCC1	umls:C0025286	BeFree	In conclusion, our study has shown that XRCC1 Gln399Arg, XRCC1 Arg194Trp, XRCC3 Thr241Met and ERCC5 Asp1558His are associated with risk of gliomas and meningiomas.	0.00764398	2013	KLC1;XRCC3	14	103699416	G	A
rs9459883	20406964	1235	CCR6	umls:C0025286	GAD	[Seventeen SNPs distributed across 12 genetic regions (NFKB1 (3), FCER1G (3), CCR6 (2), VCAM1, CD14, TNFRSF18, RAC2, XDH, C1D, TLR1/TLR10/TLR6, NOS1, and DEFA5) were associated with the risk of meningioma with P<0.01.]	0.002367032	2010	CCR6;LOC105378122	6	167117029	G	C
rs9729550	20406964	8784	TNFRSF18	umls:C0025286	GAD	[Seventeen SNPs distributed across 12 genetic regions (NFKB1 (3), FCER1G (3), CCR6 (2), VCAM1, CD14, TNFRSF18, RAC2, XDH, C1D, TLR1/TLR10/TLR6, NOS1, and DEFA5) were associated with the risk of meningioma with P<0.01.]	0.002367032	2010	NA	1	1199862	A	C

GWASdb Annotation(Total Genotypes:0)
(Waiting for update.)

GWASdb Snp Trait(Total Genotypes:1)
CHR	POS	SNPID	REF	ALT	ORI_SNPID	PMID	P_VALUE	P_VALUE_TEXT	OR/BETA	CI95_TEXT	GWAS_INITIAL_SAMPLE_SIZE	SUB_POPULATION	SUPER_POPULATION	GWAS_TRAIT	HPO_ID	HPO_TERM	DO_ID	DO_TERM	MESH_ID	MESH_TERM	EFO_ID	EFO_TERM	DOLITE_TERM	RISK_ALLELE	PUBLICATION_TYPE	AA	GENE_SYMBOL	TYPE	REFGENE
10	21830104	rs11012732	A	G	rs11012732	21804547	2.00E-14	NA	1.46	[1.32-1.61]	859 European ancestry cases; 704 European ancestry controls	European(1563)	ALL(1563)	EUR(1563)	ALL(1563)	Meningioma	HPOID:0002858	Meningioma	DOID:3565	meningioma	NA	NA	meningioma	Meningioma	rs11012732-A	Research Support, Non-U.S. Gov't	A	MLLT10	intron

Mapped by lexical matching(Total Items:0)
(Waiting for update.)

Mapped by homologous gene(Total Items:0)
(Waiting for update.)

Chemical(Total Drugs:4)
CUI	ChemicalName	ChemicalID	CasRN	DiseaseName	DiseaseID	DirectEvidence	PubMedIDs
C0025286	dydrogesterone	D004394	152-62-5	meningioma	MESH:D008579	marker/mechanism	14714974
C0025286	medroxyprogesterone acetate	D017258	71-58-9	meningioma	MESH:D008579	marker/mechanism	17586005
C0025286	megestrol acetate	D019290	51154-23-5	meningioma	MESH:D008579	marker/mechanism	19731987
C0025286	levonorgestrel	D016912	797-63-7	meningioma	MESH:D008579	marker/mechanism	8008172

FDA approved drug and dosage information(Total Drugs:0)
(Waiting for update.)

FDA labeling changes(Total Drugs:0)
(Waiting for update.)