PedAM

Pediatric Disease Annotations & Medicines


	scrub typhus

Disease ID	293
Disease	scrub typhus
Definition	An acute infectious disease caused by ORIENTIA TSUTSUGAMUSHI. It is limited to eastern and southeastern Asia, India, northern Australia, and the adjacent islands. Characteristics include the formation of a primary cutaneous lesion at the site of the bite of an infected mite, fever lasting about two weeks, and a maculopapular rash.
Synonym	disease, tsutsugamushi diseases, tsutsugamushi fever, japanese river fever, tsutsugamushi fevers, tsutsugamushi japanese river fever japanese river fever (disorder) kedani fever kedani fever (disorder) mite-borne typhus mite-borne typhus due to rickettsia tsutsugamushi scrub mite-borne typhus scrub mite-borne typhus (& various types) scrub mite-borne typhus (& various types) (disorder) scrub typhus (disorder) scrub typhus (disorder) [ambiguous] scrub typhus [disease/finding] scrubs typhus tsutsugamushi tsutsugamushi dis tsutsugamushi disease tsutsugamushi disease (disorder) tsutsugamushi diseases tsutsugamushi fever tsutsugamushi fevers typhus, scrub typhus, tropical
Orphanet	ORPHANET:83317
DOID	DOID:13371
UMLS	C0036472
MeSH	D012612
SNOMED-CT	SNOMEDCT_US_2016_09_01:271425001
Comorbidity	UMLS \| Disease \| Sentences' Count(Total Sentences:38) C0036472 \| tsutsugamushi \| 17 C0035222 \| acute respiratory distress syndrome \| 7 C1704437 \| respiratory distress syndrome \| 5 C0030305 \| pancreatitis \| 4 C0014038 \| encephalitis \| 4 C0008325 \| cholecystitis \| 3 C0015230 \| rash \| 3 C0035078 \| renal failure \| 2 C0025309 \| meningoencephalitis \| 2 C0271355 \| abducens nerve palsy \| 2 C0041471 \| typhus \| 2 C0022660 \| acute renal failure \| 2 C1145670 \| respiratory failure \| 2 C0037998 \| splenic infarction \| 1 C0012739 \| disseminated intravascular coagulation \| 1 C0024530 \| malaria \| 1 C0041466 \| typhoid \| 1 C0012739 \| disseminated intravascular coagulation (dic) \| 1 C0029089 \| ophthalmoplegia \| 1 C0024535 \| falciparum malaria \| 1 C0029134 \| optic neuritis \| 1 C0018378 \| guillain-barre syndrome \| 1 C0001623 \| adrenal insufficiency \| 1 C1565489 \| renal insufficiency \| 1 C1136085 \| monoclonal gammopathy \| 1 C0041473 \| epidemic typhus \| 1 C0031154 \| peritonitis \| 1 C0023890 \| liver cirrhosis \| 1 C0442874 \| neuropathy \| 1 C0024291 \| hemophagocytic syndrome \| 1 C0025290 \| aseptic meningitis \| 1 C0040034 \| thrombocytopenia \| 1 C0027726 \| nephrotic syndrome \| 1 C0267841 \| acalculous cholecystitis \| 1 C0024291 \| hemophagocytic lymphohistiocytosis \| 1 C0001339 \| acute pancreatitis \| 1 C0027813 \| neuritis \| 1 C0700251 \| brachial plexus neuropathy \| 1
Curated Gene	(Waiting for update.)
Inferring Gene	(Waiting for update.)
Text Mined Gene	Entrez_id \| Symbol \| Score \| Resource(Total Genes:83) 5010 \| CLDN11 \| DISEASES 28954 \| REM1 \| DISEASES 6948 \| TCN2 \| DISEASES 973 \| CD79A \| DISEASES 10392 \| NOD1 \| DISEASES 6348 \| CCL3 \| DISEASES 6347 \| CCL2 \| DISEASES 6500 \| SKP1 \| DISEASES 3336 \| HSPE1 \| DISEASES 9173 \| IL1RL1 \| DISEASES 35 \| ACADS \| DISEASES 5335 \| PLCG1 \| DISEASES 3306 \| HSPA2 \| DISEASES 6351 \| CCL4 \| DISEASES 1401 \| CRP \| DISEASES 3569 \| IL6 \| DISEASES 29113 \| C6orf15 \| DISEASES 59341 \| TRPV4 \| DISEASES 9368 \| SLC9A3R1 \| DISEASES 22858 \| ICK \| DISEASES 3553 \| IL1B \| DISEASES 4722 \| NDUFS3 \| DISEASES 6717 \| SRI \| DISEASES 5286 \| PIK3C2A \| DISEASES 5428 \| POLG \| DISEASES 126410 \| CYP4F22 \| DISEASES 3026 \| HABP2 \| DISEASES 64422 \| ATG3 \| DISEASES 1234 \| CCR5 \| DISEASES 6352 \| CCL5 \| DISEASES 64320 \| RNF25 \| DISEASES 213 \| ALB \| DISEASES 382 \| ARF6 \| DISEASES 90678 \| LRSAM1 \| DISEASES 6356 \| CCL11 \| DISEASES 23440 \| OTP \| DISEASES 214 \| ALCAM \| DISEASES 3708 \| ITPR1 \| DISEASES 10855 \| HPSE \| DISEASES 4046 \| LSP1 \| DISEASES 6363 \| CCL19 \| DISEASES 9743 \| ARHGAP32 \| DISEASES 30835 \| CD209 \| DISEASES 8411 \| EEA1 \| DISEASES 64388 \| GREM2 \| DISEASES 9235 \| IL32 \| DISEASES 8454 \| CUL1 \| DISEASES 84876 \| ORAI1 \| DISEASES 9276 \| COPB2 \| DISEASES 2152 \| F3 \| DISEASES 157567 \| ANKRD46 \| DISEASES 3329 \| HSPD1 \| DISEASES 6590 \| SLPI \| DISEASES 545 \| ATR \| DISEASES 56704 \| JPH1 \| DISEASES 23513 \| SCRIB \| DISEASES 25894 \| PLEKHG4 \| DISEASES 57829 \| ZP4 \| DISEASES 6375 \| XCL1 \| DISEASES 9447 \| AIM2 \| DISEASES 5654 \| HTRA1 \| DISEASES 2334 \| AFF2 \| DISEASES 959 \| CD40LG \| DISEASES 6385 \| SDC4 \| DISEASES 57158 \| JPH2 \| DISEASES 7099 \| TLR4 \| DISEASES 3710 \| ITPR3 \| DISEASES 9560 \| CCL4L2 \| DISEASES 23426 \| GRIP1 \| DISEASES 1654 \| DDX3X \| DISEASES 643418 \| LIPN \| DISEASES 8031 \| NCOA4 \| DISEASES 7124 \| TNF \| DISEASES 388372 \| CCL4L1 \| DISEASES 3920 \| LAMP2 \| DISEASES 4050 \| LTB \| DISEASES 3586 \| IL10 \| DISEASES 4345 \| CD200 \| DISEASES 2920 \| CXCL2 \| DISEASES 51366 \| UBR5 \| DISEASES 3620 \| IDO1 \| DISEASES 246734 \| NPCDR1 \| DISEASES 100885779 \| LINC-ROR \| DISEASES
Locus	(Waiting for update.)

Disease ID	293
Disease	scrub typhus
Integrated Phenotype	HPO \| Name(Total Integrated Phenotypes:27) HP:0012735 \| Cough HP:0004372 \| Reduced consciousness/confusion HP:0012733 \| Macule HP:0000988 \| Skin rash HP:0000708 \| Behavioral abnormality HP:0002716 \| Lymphadenopathy HP:0003326 \| Myalgia HP:0001945 \| Fever HP:0001254 \| Lethargy HP:0002315 \| Headache HP:0001744 \| Splenomegaly HP:0001250 \| Seizures HP:0001892 \| Abnormal bleeding HP:0012122 \| Anterior uveitis HP:0100758 \| Gangrene HP:0000083 \| Renal insufficiency HP:0002094 \| Dyspnea HP:0002091 \| Restrictive lung disease HP:0002615 \| Hypotension HP:0000975 \| Hyperhidrosis HP:0002017 \| Nausea and vomiting HP:0002383 \| Encephalitis HP:0012819 \| Myocarditis HP:0001287 \| Meningitis HP:0000613 \| Photophobia HP:0002027 \| Abdominal pain HP:0001337 \| Tremor
Text Mined Phenotype	HPO \| Name \| Sentences' Count(Total Phenotypes:32) HP:0001945 \| Fever \| 5 HP:0001733 \| Pancreatic inflammation \| 4 HP:0001919 \| Acute renal failure \| 4 HP:0002098 \| Respiratory distress \| 4 HP:0000083 \| Renal insufficiency \| 3 HP:0003073 \| Hypoalbuminaemia \| 3 HP:0010543 \| Opsoclonus \| 3 HP:0002383 \| Encephalitis \| 3 HP:0001082 \| Cholecystitis \| 3 HP:0012531 \| Pain \| 2 HP:0012156 \| Hemophagocytosis \| 2 HP:0002878 \| Respiratory failure \| 2 HP:0001300 \| Parkinsonism \| 2 HP:0001873 \| Low platelet count \| 1 HP:0003201 \| Rhabdomyolysis \| 1 HP:0100653 \| Optic neuritis \| 1 HP:0000100 \| Nephrosis \| 1 HP:0045054 \| Brachial plexus neuropathy \| 1 HP:0000602 \| Ophthalmoplegia \| 1 HP:0002586 \| Peritonitis \| 1 HP:0002315 \| Headaches \| 1 HP:0001735 \| Acute pancreatitis \| 1 HP:0002027 \| Abdominal pain \| 1 HP:0002240 \| Enlarged liver \| 1 HP:0000846 \| Hypoadrenalism \| 1 HP:0002367 \| Visual hallucinations \| 1 HP:0001410 \| Decreased liver function \| 1 HP:0100806 \| Sepsis \| 1 HP:0005521 \| Disseminated intravascular coagulation \| 1 HP:0003326 \| Muscle pain \| 1 HP:0002716 \| Lymph node hyperplasia \| 1 HP:0002202 \| Pleural effusion \| 1

Disease ID	293
Disease	scrub typhus
Manually Symptom	UMLS \| Name(Total Manually Symptoms:21) C2707258 \| infections C2598155 \| pain C2364133 \| infection C2362319 \| acute respiratory distress syndrome (ards) C2029884 \| hearing loss C1962971 \| myocarditis C0743841 \| febrile illness C0700251 \| brachial plexus neuropathy C0553681 \| hypofibrinogenemia C0426576 \| gastrointestinal symptoms C0270627 \| acute transverse myelitis C0235369 \| granulomatous hepatitis C0206061 \| interstitial pneumonia C0152025 \| polyneuropathy C0036472 \| tsutsugamushi C0035222 \| acute respiratory distress syndrome C0022660 \| acute renal failure C0018681 \| headaches C0013456 \| otalgia C0012739 \| disseminated intravascular coagulation C0000727 \| acute abdomen
Text Mined Symptom	UMLS \| Name \| Sentences' Count(Total Symptoms:12) C0036472 \| tsutsugamushi \| 17 C0743841 \| febrile illness \| 11 C0009450 \| infection \| 7 C0035222 \| acute respiratory distress syndrome \| 5 C0022660 \| acute renal failure \| 2 C2362319 \| acute respiratory distress syndrome (ards) \| 2 C0021311 \| infections \| 2 C0030193 \| pain \| 2 C0700251 \| brachial plexus neuropathy \| 1 C0018681 \| headaches \| 1 C0012739 \| disseminated intravascular coagulation \| 1 C0000727 \| acute abdomen \| 1

Manually Genotype(Total Text Mining Genotypes:0)
(Waiting for update.)

All Snps(Total Genotypes:0)
(Waiting for update.)

GWASdb Annotation(Total Genotypes:0)
(Waiting for update.)

GWASdb Snp Trait(Total Genotypes:0)
(Waiting for update.)

Mapped by lexical matching(Total Items:1)
HP ID	HP Name	MP ID	MP Name	Annotation
HP:0000083	Renal insufficiency	MP:0003335	exocrine pancreatic insufficiency;HP:0004370	Abnormality of temperature regulation

Mapped by homologous gene(Total Items:1)
HP ID	HP Name	MP ID	MP Name	Annotation
HP:0002716	Lymphadenopathy	MP:0002420	abnormal adaptive immunity;HP:0002615	Hypotension

Chemical(Total Drugs:0)
(Waiting for update.)

FDA approved drug and dosage information(Total Drugs:0)
(Waiting for update.)

FDA labeling changes(Total Drugs:0)
(Waiting for update.)

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