PedAM

Pediatric Disease Annotations & Medicines


	scleritis

Disease ID	783
Disease	scleritis
Definition	Refers to any inflammation of the sclera including episcleritis, a benign condition affecting only the episclera, which is generally short-lived and easily treated. Classic scleritis, on the other hand, affects deeper tissue and is characterized by higher rates of visual acuity loss and even mortality, particularly in necrotizing form. Its characteristic symptom is severe and general head pain. Scleritis has also been associated with systemic collagen disease. Etiology is unknown but is thought to involve a local immune response. Treatment is difficult and includes administration of anti-inflammatory and immunosuppressive agents such as corticosteroids. Inflammation of the sclera may also be secondary to inflammation of adjacent tissues, such as the conjunctiva.
Synonym	inflammation of the outer white part of the eye inflammation of white of eye scleritides scleritis (disorder) scleritis [disease/finding] scleritis nos scleritis, nos scleritis, unspecified unspecified scleritis unspecified scleritis (disorder)
DOID	DOID:13452
UMLS	C0036416
MeSH	D015423
SNOMED-CT	SNOMEDCT_US_2016_09_01:78370002
Comorbidity	UMLS \| Disease \| Sentences' Count(Total Sentences:44) C0003873 \| rheumatoid arthritis \| 8 C0003864 \| arthritis \| 4 C0021053 \| immune disorders \| 3 C0035305 \| retinal detachment \| 3 C0042164 \| uveitis \| 3 C0021053 \| immune disorder \| 3 C0009782 \| connective tissue disease \| 2 C0035328 \| retinal vein occlusion \| 2 C0017601 \| glaucoma \| 2 C0154841 \| central retinal vein occlusion \| 2 C0034212 \| pyoderma \| 2 C0085652 \| pyoderma gangrenosum \| 2 C0003873 \| rheumatoid disease \| 2 C0042384 \| vasculitis \| 2 C0024141 \| systemic lupus erythematosus \| 1 C0017605 \| angle closure glaucoma \| 1 C0004106 \| astigmatism \| 1 C0019196 \| hepatitis c \| 1 C1136085 \| monoclonal gammopathy \| 1 C0007570 \| coeliac disease \| 1 C0042164 \| intraocular inflammation \| 1 C0023493 \| adult t-cell leukemia/lymphoma \| 1 C0017661 \| iga nephropathy \| 1 C0281658 \| intraocular lymphoma \| 1 C0014236 \| endophthalmitis \| 1 C0026470 \| monoclonal gammopathy of undetermined significance \| 1 C0409974 \| lupus erythematosus \| 1 C0086543 \| cataract \| 1 C0035333 \| retinitis \| 1 C0023493 \| adult t-cell leukemia \| 1 C0019360 \| herpes zoster infection \| 1 C0010346 \| crohn disease \| 1 C0042165 \| anterior uveitis \| 1 C0032453 \| relapsing polychondritis \| 1 C0008513 \| retinochoroiditis \| 1 C0023434 \| chronic lymphocytic leukemia \| 1 C0023448 \| lymphocytic leukemia \| 1 C0041296 \| tuberculosis \| 1 C0730306 \| ocular lymphoma \| 1 C0019360 \| herpes zoster \| 1 C0154733 \| multiple cranial nerve palsies \| 1 C0022658 \| nephropathy \| 1 C0024299 \| lymphoma \| 1 C0023492 \| t-cell leukemia \| 1
Curated Gene	(Waiting for update.)
Inferring Gene	(Waiting for update.)
Text Mined Gene	Entrez_id \| Symbol \| Score \| Resource(Total Genes:52) 1634 \| DCN \| DISEASES 933 \| CD22 \| DISEASES 1414 \| CRYBB1 \| DISEASES 1511 \| CTSG \| DISEASES 7076 \| TIMP1 \| DISEASES 8797 \| TNFRSF10A \| DISEASES 973 \| CD79A \| DISEASES 5949 \| RBP3 \| DISEASES 4353 \| MPO \| DISEASES 3558 \| IL2 \| DISEASES 3567 \| IL5 \| DISEASES 3554 \| IL1R1 \| DISEASES 5657 \| PRTN3 \| DISEASES 1088 \| CEACAM8 \| DISEASES 4298 \| MLLT1 \| DISEASES 1401 \| CRP \| DISEASES 4907 \| NT5E \| DISEASES 3557 \| IL1RN \| DISEASES 1387 \| CREBBP \| DISEASES 3552 \| IL1A \| DISEASES 80725 \| SRCIN1 \| DISEASES 79109 \| MAPKAP1 \| DISEASES 25793 \| FBXO7 \| DISEASES 6271 \| S100A1 \| DISEASES 3549 \| IHH \| DISEASES 7123 \| CLEC3B \| DISEASES 115825 \| WDFY2 \| DISEASES 4314 \| MMP3 \| DISEASES 56947 \| MFF \| DISEASES 10736 \| SIX2 \| DISEASES 56246 \| MRAP \| DISEASES 196883 \| ADCY4 \| DISEASES 931 \| MS4A1 \| DISEASES 4312 \| MMP1 \| DISEASES 633 \| BGN \| DISEASES 50616 \| IL22 \| DISEASES 8651 \| SOCS1 \| DISEASES 6540 \| SLC6A13 \| DISEASES 3605 \| IL17A \| DISEASES 6539 \| SLC6A12 \| DISEASES 4512 \| MT-CO1 \| DISEASES 7390 \| UROS \| DISEASES 7062 \| TCHH \| DISEASES 1810 \| DR1 \| DISEASES 959 \| CD40LG \| DISEASES 4318 \| MMP9 \| DISEASES 7133 \| TNFRSF1B \| DISEASES 7454 \| WAS \| DISEASES 5394 \| EXOSC10 \| DISEASES 7913 \| DEK \| DISEASES 6295 \| SAG \| DISEASES 7124 \| TNF \| DISEASES
Locus	(Waiting for update.)

Disease ID	783
Disease	scleritis
Integrated Phenotype	(Waiting for update.)
Text Mined Phenotype	HPO \| Name \| Sentences' Count(Total Phenotypes:25) HP:0001370 \| Rheumatoid arthritis \| 8 HP:0001369 \| Arthritis \| 4 HP:0012531 \| Pain \| 3 HP:0000554 \| Uveitis \| 3 HP:0002960 \| Autoimmune condition \| 3 HP:0000541 \| Detached retina \| 3 HP:0000999 \| Pyoderma \| 2 HP:0002633 \| Vasculitis \| 2 HP:0000501 \| Glaucoma \| 2 HP:0001059 \| Pterygium \| 2 HP:0002955 \| Granulomatosis \| 2 HP:0100533 \| Ocular inflammation \| 2 HP:0012636 \| Retinal vein occlusion \| 2 HP:0002664 \| Neoplasia \| 2 HP:0012122 \| Anterior uveitis \| 1 HP:0010783 \| Erythema \| 1 HP:0002725 \| Systemic lupus erythematosus \| 1 HP:0005550 \| Chronic lymphatic leukemia \| 1 HP:0012231 \| Exudative retinal detachment \| 1 HP:0000112 \| Nephropathy \| 1 HP:0000518 \| Cataract \| 1 HP:0012219 \| Erythema nodosum \| 1 HP:0006824 \| Cranial nerve palsy \| 1 HP:0000483 \| Astigmatism \| 1 HP:0002665 \| Lymphoma \| 1

Disease ID	783
Disease	scleritis
Manually Symptom	UMLS \| Name(Total Manually Symptoms:10) C2598155 \| pain C2350476 \| orbital myositis C1963266 \| uveitis C1963229 \| retinal detachment C1962986 \| glaucoma C1373218 \| immunosuppression C0035305 \| retinal detachments C0029896 \| ent disease C0027092 \| myopia C0022568 \| keratitis
Text Mined Symptom	UMLS \| Name \| Sentences' Count(Total Symptoms:4) C0042164 \| uveitis \| 3 C0030193 \| pain \| 3 C0035305 \| retinal detachment \| 3 C0017601 \| glaucoma \| 2

Manually Genotype(Total Text Mining Genotypes:0)
(Waiting for update.)

All Snps(Total Genotypes:0)
(Waiting for update.)

GWASdb Annotation(Total Genotypes:0)
(Waiting for update.)

GWASdb Snp Trait(Total Genotypes:0)
(Waiting for update.)

Mapped by lexical matching(Total Items:0)
(Waiting for update.)

Mapped by homologous gene(Total Items:0)
(Waiting for update.)

Chemical(Total Drugs:2)
CUI	ChemicalName	ChemicalID	CasRN	DiseaseName	DiseaseID	DirectEvidence	PubMedIDs
C0036416	cimetidine	D002927	51481-61-9	scleritis	MESH:D015423	marker/mechanism	6294351
C0036416	propylthiouracil	D011441	51-52-5	scleritis	MESH:D015423	marker/mechanism	9181282

FDA approved drug and dosage information(Total Drugs:0)
(Waiting for update.)

FDA labeling changes(Total Drugs:0)
(Waiting for update.)

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