PedAM
Pediatric Disease Annotations & Medicines
| salmonella infections | ||||
| Disease ID | 1663 |
|---|---|
| Disease | salmonella infections |
| Definition | Infections with bacteria of the genus SALMONELLA. |
| Synonym | [x]salmonella infection, unspecified [x]salmonella infection, unspecified (disorder) infect salmonella infection, salmonella infections, salmonella salmonella infect salmonella infection salmonella infection (disorder) salmonella infection nos salmonella infection nos (disorder) salmonella infection, unspecified salmonella infections [disease/finding] salmonelloses |
| ICD10 | |
| UMLS | C0036117 |
| MeSH | |
| SNOMED-CT | |
| Comorbidity | UMLS | Disease | Sentences' Count(Total Sentences:19) C0011991 | diarrhea | 4 C0017160 | gastroenteritis | 2 C0036114 | salmonellosis | 2 C0011991 | diarrhoea | 2 C0038353 | gastric dilatation | 1 C0042109 | urticaria | 1 C0025289 | meningitis | 1 C0004623 | bacterial infection | 1 C0036117 | salmonella infect | 1 C0025469 | mesenteric lymphadenitis | 1 C0024205 | lymphadenitis | 1 C0162871 | abdominal aortic aneurysm | 1 C0002895 | sickle cell disease | 1 C0003486 | aortic aneurysm | 1 C0149642 | cervical lymphadenitis | 1 C0008354 | cholera | 1 C0036117 | salmonella infection | 1 C0003615 | appendicitis | 1 C0024530 | malaria | 1 |
| Curated Gene | (Waiting for update.) |
| Inferring Gene | (Waiting for update.) |
| Text Mined Gene | (Waiting for update.) |
| Locus | (Waiting for update.) |
| Disease ID | 1663 |
|---|---|
| Disease | salmonella infections |
| Integrated Phenotype | (Waiting for update.) |
| Text Mined Phenotype | HPO | Name | Sentences' Count(Total Phenotypes:14) HP:0002014 | Diarrhea | 4 HP:0001945 | Fever | 2 HP:0002617 | Aneurysmal dilatation | 2 HP:0001025 | Hives | 1 HP:0002018 | Nausea | 1 HP:0002840 | Lymphadenitis | 1 HP:0010783 | Erythema | 1 HP:0004942 | Aortic aneurysm | 1 HP:0001287 | Meningitis | 1 HP:0100806 | Sepsis | 1 HP:0012219 | Erythema nodosum | 1 HP:0001824 | Weight loss | 1 HP:0004953 | Abdominal aortic aneurysm | 1 HP:0003470 | Inability to move | 1 |
| Disease ID | 1663 |
|---|---|
| Disease | salmonella infections |
| Manually Symptom | (Waiting for update.) |
| Text Mined Symptom | UMLS | Name | Sentences' Count(Total Symptoms:5) C0011991 | diarrhoea | 2 C0002940 | aneurysm | 2 C0017160 | gastroenteritis | 2 C0748159 | pulmonary involvement | 1 C0036690 | sepsis | 1 |
Manually Genotype(Total Text Mining Genotypes:0) |
|---|
| (Waiting for update.) |
All Snps(Total Genotypes:0) | |
|---|---|
| (Waiting for update.) | |
GWASdb Annotation(Total Genotypes:0) | |
|---|---|
| (Waiting for update.) | |
GWASdb Snp Trait(Total Genotypes:0) | |
|---|---|
| (Waiting for update.) | |
Mapped by lexical matching(Total Items:0) |
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| (Waiting for update.) |
Mapped by homologous gene(Total Items:0) |
|---|
| (Waiting for update.) |
Chemical(Total Drugs:6) | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| CUI | ChemicalName | ChemicalID | CasRN | DiseaseName | DiseaseID | DirectEvidence | PubMedIDs | ||
| C0036117 | ampicillin | D000667 | 69-53-4 | salmonella infections | MESH:D012480 | therapeutic | 8807045 | ||
| C0036117 | cefotaxime | D002439 | 63527-52-6 | salmonella infections | MESH:D012480 | therapeutic | 8807045 | ||
| C0036117 | chloramphenicol | D002701 | 56-75-7 | salmonella infections | MESH:D012480 | therapeutic | 839647 | ||
| C0036117 | ciprofloxacin | D002939 | 85721-33-1 | salmonella infections | MESH:D012480 | therapeutic | 8219437 | ||
| C0036117 | ofloxacin | D015242 | 82419-36-1 | salmonella infections | MESH:D012480 | therapeutic | 8807045 | ||
| C0036117 | pefloxacin | D015366 | 70458-92-3 | salmonella infections | MESH:D012480 | therapeutic | 9759304 | ||
FDA approved drug and dosage information(Total Drugs:2) | ||||||||
|---|---|---|---|---|---|---|---|---|
| DiseaseID | Drug_name | active_ingredients | strength | Dosage Form/Route | Marketing Status | TE code | RLD | RS |
| MESH:D012480 | cipro | ciprofloxacin | 400MG/40ML (10MG/ML) | INJECTABLE;INJECTION | Discontinued | None | Yes | No |
| MESH:D012480 | cipro | ciprofloxacin | 250MG/5ML | FOR SUSPENSION;ORAL | Prescription | AB | Yes | No |
FDA labeling changes(Total Drugs:2) | |||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| DiseaseID | Pediatric_Labeling_Date | Trade_Name | Generic_Name_or_Proper_Name | Indications Studied | Label Changes Summary | Product Labeling | BPCA(B) | PREA(P) | BPCA(B) and PREA(P) | Pediatric Rule (R) | Sponsor | Pediatric Exclusivity Granted Date | NNPS |
| MESH:D012480 | 03/25/2004 | cipro | ciprofloxacin | Complicated UTI and pyelonephritis | Indicated for the treatment of complicated urinary tract infections (cUTIs) and pyelonephritis in pediatric patients 1 17 years of age Not drug of first choice due to increased adverse events compared to controls including events related to joints and/or surrounding tissues Information on PK and dose in pediatric patients 1 17 years of age The most frequent adverse events observed within 6 weeks of treatment initiation during the cUTI clinical trial were gastrointestinal 15% compared to 9% and musculoskeletal 9.3% compared to 6% in ciprofloxacin-treated compared to control-treated patients, respectively | Labeling | B | - | - | - | Bayer | 12/18/2003 | FALSE' |
| MESH:D012480 | 03/25/2004 | cipro | ciprofloxacin | Complicated UTI and pyelonephritis | Indicated for the treatment of complicated urinary tract infections (cUTIs) and pyelonephritis in pediatric patients 1 17 years of age Not drug of first choice due to increased adverse events compared to controls including events related to joints and/or surrounding tissues Information on PK and dose in pediatric patients 1 17 years of age The most frequent adverse events observed within 6 weeks of treatment initiation during the cUTI clinical trial were gastrointestinal 15% compared to 9% and musculoskeletal 9.3% compared to 6% in ciprofloxacin-treated compared to control-treated patients, respectively | Labeling | B | - | - | - | Bayer | 12/18/2003 | FALSE' |