PedAM
Pediatric Disease Annotations & Medicines
| rubella | ||||
| Disease ID | 1232 |
|---|---|
| Disease | rubella |
| Integrated Phenotype | (Waiting for update.) |
| Text Mined Phenotype | HPO | Name | Sentences' Count(Total Phenotypes:24) HP:0000554 | Uveitis | 4 HP:0001945 | Fever | 4 HP:0000717 | Autism | 3 HP:0000519 | Cataracts, lenticular, bilateral | 3 HP:0000518 | Cataract | 3 HP:0011134 | Mild fever | 2 HP:0002960 | Autoimmune condition | 2 HP:0006554 | Acute hepatic failure | 1 HP:0001520 | Birthweight > 90th percentile | 1 HP:0001399 | Liver failure | 1 HP:0000078 | Genital abnormalities | 1 HP:0001289 | Confusion | 1 HP:0001369 | Arthritis | 1 HP:0010628 | Facial palsy, unilateral or bilateral | 1 HP:0000365 | Hearing impairment | 1 HP:0012531 | Pain | 1 HP:0002383 | Encephalitis | 1 HP:0000618 | Blindness | 1 HP:0100796 | Orchitis | 1 HP:0100033 | Tic disorder | 1 HP:0001250 | Seizures | 1 HP:0001094 | Iridocyclitis | 1 HP:0001332 | Dystonia | 1 HP:0030449 | Therapeutic abortion | 1 |
| Disease ID | 1232 |
|---|---|
| Disease | rubella |
| Manually Symptom | (Waiting for update.) |
| Text Mined Symptom | UMLS | Name | Sentences' Count(Total Symptoms:12) C0009450 | infection | 32 C0021311 | infections | 6 C0015230 | rash | 5 C0275544 | congenital infection | 4 C0086543 | cataract | 2 C0024291 | hemophagocytic syndrome | 1 C0014038 | encephalitis | 1 C1397629 | fetal infection | 1 C0086543 | cataracts | 1 C1384666 | hearing impairment | 1 C0003864 | arthritis | 1 C0162557 | acute liver failure | 1 |
Manually Genotype(Total Text Mining Genotypes:0) |
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| (Waiting for update.) |
All Snps(Total Genotypes:15) | |||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| snpId | pubmedId | geneId | geneSymbol | diseaseId | sourceId | sentence | score | Year | geneSymbol_dbSNP | CHROMOSOME | POS | REF | ALT |
| rs2284552 | 25139337 | 3593 | IL12B | umls:C0035920 | BeFree | Significant associations were also found between IL10RB (rs2284552; measles study p value 0.006, rubella study p value 0.00008) and IL12B (rs2546893; measles study p value 0.005, rubella study p value 0.03) gene polymorphisms and variations in both measles- and rubella virus-specific IL-6 responses. | 0.002909916 | 2014 | IL10RB | 21 | 33271777 | G | T |
| rs2284552 | 25139337 | 3588 | IL10RB | umls:C0035920 | BeFree | Significant associations were also found between IL10RB (rs2284552; measles study p value 0.006, rubella study p value 0.00008) and IL12B (rs2546893; measles study p value 0.005, rubella study p value 0.03) gene polymorphisms and variations in both measles- and rubella virus-specific IL-6 responses. | 0.003181358 | 2014 | IL10RB | 21 | 33271777 | G | T |
| rs2284552 | 25139337 | 3569 | IL6 | umls:C0035920 | BeFree | Significant associations were also found between IL10RB (rs2284552; measles study p value 0.006, rubella study p value 0.00008) and IL12B (rs2546893; measles study p value 0.005, rubella study p value 0.03) gene polymorphisms and variations in both measles- and rubella virus-specific IL-6 responses. | 0.003724241 | 2014 | IL10RB | 21 | 33271777 | G | T |
| rs2546893 | 25139337 | 3588 | IL10RB | umls:C0035920 | BeFree | Significant associations were also found between IL10RB (rs2284552; measles study p value 0.006, rubella study p value 0.00008) and IL12B (rs2546893; measles study p value 0.005, rubella study p value 0.03) gene polymorphisms and variations in both measles- and rubella virus-specific IL-6 responses. | 0.003181358 | 2014 | IL12B | 5 | 159328952 | G | A |
| rs2546893 | 25139337 | 3569 | IL6 | umls:C0035920 | BeFree | Significant associations were also found between IL10RB (rs2284552; measles study p value 0.006, rubella study p value 0.00008) and IL12B (rs2546893; measles study p value 0.005, rubella study p value 0.03) gene polymorphisms and variations in both measles- and rubella virus-specific IL-6 responses. | 0.003724241 | 2014 | IL12B | 5 | 159328952 | G | A |
| rs2546893 | 25139337 | 3593 | IL12B | umls:C0035920 | BeFree | Significant associations were also found between IL10RB (rs2284552; measles study p value 0.006, rubella study p value 0.00008) and IL12B (rs2546893; measles study p value 0.005, rubella study p value 0.03) gene polymorphisms and variations in both measles- and rubella virus-specific IL-6 responses. | 0.002909916 | 2014 | IL12B | 5 | 159328952 | G | A |
| rs2844482 | 20923569 | 3569 | IL6 | umls:C0035920 | BeFree | Single-SNP assessments identified 4 SNPs that appeared to be univariately associated with rubella antibody levels: rs2844482 (p = 0.0002) and rs2857708 (p = 0.001) in the 5'UTR of the LTA gene, rs7801617 in the 5'UTR of the IL6 gene (p = 0.0005), and rs4787947 in the 5'UTR of the IL4R gene (p = 0.002). | 0.003724241 | 2010 | LTA;LOC100287329 | 6 | 31571990 | C | T |
| rs2844482 | 20923569 | 3566 | IL4R | umls:C0035920 | BeFree | Single-SNP assessments identified 4 SNPs that appeared to be univariately associated with rubella antibody levels: rs2844482 (p = 0.0002) and rs2857708 (p = 0.001) in the 5'UTR of the LTA gene, rs7801617 in the 5'UTR of the IL6 gene (p = 0.0005), and rs4787947 in the 5'UTR of the IL4R gene (p = 0.002). | 0.002909916 | 2010 | LTA;LOC100287329 | 6 | 31571990 | C | T |
| rs2857708 | 20923569 | 3566 | IL4R | umls:C0035920 | BeFree | Single-SNP assessments identified 4 SNPs that appeared to be univariately associated with rubella antibody levels: rs2844482 (p = 0.0002) and rs2857708 (p = 0.001) in the 5'UTR of the LTA gene, rs7801617 in the 5'UTR of the IL6 gene (p = 0.0005), and rs4787947 in the 5'UTR of the IL4R gene (p = 0.002). | 0.002909916 | 2010 | LTA;LOC100287329 | 6 | 31565829 | C | T |
| rs2857708 | 20923569 | 3569 | IL6 | umls:C0035920 | BeFree | Single-SNP assessments identified 4 SNPs that appeared to be univariately associated with rubella antibody levels: rs2844482 (p = 0.0002) and rs2857708 (p = 0.001) in the 5'UTR of the LTA gene, rs7801617 in the 5'UTR of the IL6 gene (p = 0.0005), and rs4787947 in the 5'UTR of the IL4R gene (p = 0.002). | 0.003724241 | 2010 | LTA;LOC100287329 | 6 | 31565829 | C | T |
| rs4787947 | 20923569 | 3569 | IL6 | umls:C0035920 | BeFree | Single-SNP assessments identified 4 SNPs that appeared to be univariately associated with rubella antibody levels: rs2844482 (p = 0.0002) and rs2857708 (p = 0.001) in the 5'UTR of the LTA gene, rs7801617 in the 5'UTR of the IL6 gene (p = 0.0005), and rs4787947 in the 5'UTR of the IL4R gene (p = 0.002). | 0.003724241 | 2010 | NA | 16 | 27307444 | G | T |
| rs4787947 | 20923569 | 3566 | IL4R | umls:C0035920 | BeFree | Single-SNP assessments identified 4 SNPs that appeared to be univariately associated with rubella antibody levels: rs2844482 (p = 0.0002) and rs2857708 (p = 0.001) in the 5'UTR of the LTA gene, rs7801617 in the 5'UTR of the IL6 gene (p = 0.0005), and rs4787947 in the 5'UTR of the IL4R gene (p = 0.002). | 0.002909916 | 2010 | NA | 16 | 27307444 | G | T |
| rs669260 | 25139337 | 4360 | MRC1 | umls:C0035920 | BeFree | An intronic SNP (rs669260) in the antiviral innate immune receptor gene, DDX58, was significantly associated with increased neutralizing antibody titers for both measles and rubella viral antigens post-MMR vaccination (p values 0.02 and 0.0002, respectively). | 0.000814326 | 2014 | DDX58 | 9 | 32503442 | T | C |
| rs7801617 | 20923569 | 3566 | IL4R | umls:C0035920 | BeFree | Single-SNP assessments identified 4 SNPs that appeared to be univariately associated with rubella antibody levels: rs2844482 (p = 0.0002) and rs2857708 (p = 0.001) in the 5'UTR of the LTA gene, rs7801617 in the 5'UTR of the IL6 gene (p = 0.0005), and rs4787947 in the 5'UTR of the IL4R gene (p = 0.002). | 0.002909916 | 2010 | NA | 7 | 22718463 | G | A |
| rs7801617 | 20923569 | 3569 | IL6 | umls:C0035920 | BeFree | Single-SNP assessments identified 4 SNPs that appeared to be univariately associated with rubella antibody levels: rs2844482 (p = 0.0002) and rs2857708 (p = 0.001) in the 5'UTR of the LTA gene, rs7801617 in the 5'UTR of the IL6 gene (p = 0.0005), and rs4787947 in the 5'UTR of the IL4R gene (p = 0.002). | 0.003724241 | 2010 | NA | 7 | 22718463 | G | A |
GWASdb Annotation(Total Genotypes:0) | |
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| (Waiting for update.) | |
GWASdb Snp Trait(Total Genotypes:0) | |
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| (Waiting for update.) | |
Mapped by lexical matching(Total Items:0) |
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| (Waiting for update.) |
Mapped by homologous gene(Total Items:0) |
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| (Waiting for update.) |
Chemical(Total Drugs:0) | |
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| (Waiting for update.) | |
FDA approved drug and dosage information(Total Drugs:0) | |
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| (Waiting for update.) | |
FDA labeling changes(Total Drugs:0) | |
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| (Waiting for update.) | |