PedAM

Pediatric Disease Annotations & Medicines


	root resorption

Disease ID	1481
Disease	root resorption
Definition	Resorption in which cementum or dentin is lost from the root of a tooth owing to cementoclastic or osteoclastic activity in conditions such as trauma of occlusion or neoplasms. (Dorland, 27th ed)
Synonym	resorption root resorption, root resorptions, root root resorption [disease/finding] root resorptions
DOID	DOID:14550
UMLS	C0035851
MeSH	D012391
Comorbidity	UMLS \| Disease \| Sentences' Count(Total Sentences:11) C0031099 \| periodontitis \| 3 C0031030 \| apical periodontitis \| 2 C0002448 \| ameloblastoma \| 2 C0031090 \| periodontal disease \| 1 C0034103 \| pulpitis \| 1 C0011334 \| caries \| 1 C0003090 \| ankylosis \| 1 C0039494 \| temporomandibular joint disorder \| 1 C0008029 \| cherubism \| 1 C0011334 \| cavities \| 1 C0162855 \| mucinosis \| 1
Curated Gene	(Waiting for update.)
Inferring Gene	Entrez_id \| Symbol \| Resource(Total Genes:1) 3553 \| IL1B \| infer
Text Mined Gene	Entrez_id \| Symbol \| Score \| Resource(Total Genes:104) 50865 \| HEBP1 \| DISEASES 57554 \| LRRC7 \| DISEASES 1634 \| DCN \| DISEASES 5010 \| CLDN11 \| DISEASES 28962 \| OSTM1 \| DISEASES 266 \| AMELY \| DISEASES 129138 \| ANKRD54 \| DISEASES 10857 \| PGRMC1 \| DISEASES 54 \| ACP5 \| DISEASES 3381 \| IBSP \| DISEASES 10094 \| ARPC3 \| DISEASES 6678 \| SPARC \| DISEASES 3565 \| IL4 \| DISEASES 8600 \| TNFSF11 \| DISEASES 652 \| BMP4 \| DISEASES 57152 \| SLURP1 \| DISEASES 968 \| CD68 \| DISEASES 182 \| JAG1 \| DISEASES 2799 \| GNS \| DISEASES 3569 \| IL6 \| DISEASES 3557 \| IL1RN \| DISEASES 23314 \| SATB2 \| DISEASES 25939 \| SAMHD1 \| DISEASES 1326 \| MAP3K8 \| DISEASES 3552 \| IL1A \| DISEASES 3553 \| IL1B \| DISEASES 64135 \| IFIH1 \| DISEASES 4162 \| MCAM \| DISEASES 79594 \| MUL1 \| DISEASES 2247 \| FGF2 \| DISEASES 6595 \| SMARCA2 \| DISEASES 1513 \| CTSK \| DISEASES 151449 \| GDF7 \| DISEASES 64651 \| CSRNP1 \| DISEASES 4851 \| NOTCH1 \| DISEASES 1834 \| DSPP \| DISEASES 7345 \| UCHL1 \| DISEASES 1436 \| CSF1R \| DISEASES 163786 \| SASS6 \| DISEASES 3856 \| KRT8 \| DISEASES 4982 \| TNFRSF11B \| DISEASES 9780 \| PIEZO1 \| DISEASES 50964 \| SOST \| DISEASES 3688 \| ITGB1 \| DISEASES 9902 \| MRC2 \| DISEASES 11280 \| SCN11A \| DISEASES 258 \| AMBN \| DISEASES 64388 \| GREM2 \| DISEASES 6863 \| TAC1 \| DISEASES 5745 \| PTH1R \| DISEASES 23212 \| RRS1 \| DISEASES 4312 \| MMP1 \| DISEASES 633 \| BGN \| DISEASES 1435 \| CSF1 \| DISEASES 8905 \| AP1S2 \| DISEASES 796 \| CALCA \| DISEASES 23545 \| ATP6V0A2 \| DISEASES 63826 \| SRR \| DISEASES 26578 \| OSTF1 \| DISEASES 3605 \| IL17A \| DISEASES 79971 \| WLS \| DISEASES 2331 \| FMOD \| DISEASES 6597 \| SMARCA4 \| DISEASES 126014 \| OSCAR \| DISEASES 6693 \| SPN \| DISEASES 1825 \| DSC3 \| DISEASES 10319 \| LAMC3 \| DISEASES 5743 \| PTGS2 \| DISEASES 632 \| BGLAP \| DISEASES 7286 \| TUFT1 \| DISEASES 1520 \| CTSS \| DISEASES 3654 \| IRAK1 \| DISEASES 860 \| RUNX2 \| DISEASES 3437 \| IFIT3 \| DISEASES 4318 \| MMP9 \| DISEASES 113452 \| TMEM54 \| DISEASES 22943 \| DKK1 \| DISEASES 8200 \| GDF5 \| DISEASES 249 \| ALPL \| DISEASES 54829 \| ASPN \| DISEASES 50943 \| FOXP3 \| DISEASES 27237 \| ARHGEF16 \| DISEASES 650 \| BMP2 \| DISEASES 265 \| AMELX \| DISEASES 6541 \| SLC7A1 \| DISEASES 2618 \| GART \| DISEASES 752014 \| CEMP1 \| DISEASES 1186 \| CLCN7 \| DISEASES 10575 \| CCT4 \| DISEASES 6696 \| SPP1 \| DISEASES 79924 \| ADM2 \| DISEASES 5744 \| PTHLH \| DISEASES 23365 \| ARHGEF12 \| DISEASES 6345 \| SRL \| DISEASES 57703 \| CWC22 \| DISEASES 3833 \| KIFC1 \| DISEASES 7124 \| TNF \| DISEASES 3109 \| HLA-DMB \| DISEASES 54677 \| CROT \| DISEASES 6452 \| SH3BP2 \| DISEASES 5027 \| P2RX7 \| DISEASES 8792 \| TNFRSF11A \| DISEASES 54757 \| FAM20A \| DISEASES 79104 \| MEG8 \| DISEASES
Locus	(Waiting for update.)

Disease ID	1481
Disease	root resorption
Integrated Phenotype	(Waiting for update.)
Text Mined Phenotype	HPO \| Name \| Sentences' Count(Total Phenotypes:12) HP:0000700 \| Periapical radiolucency \| 4 HP:0000704 \| Pyorrhea \| 3 HP:0100246 \| Osteoma \| 1 HP:0012378 \| Fatigue \| 1 HP:0012531 \| Pain \| 1 HP:0011094 \| Increased overlap of upper and lower incisors \| 1 HP:0001571 \| Impacted teeth \| 1 HP:0012393 \| Allergy \| 1 HP:0000670 \| Dental caries \| 1 HP:0002006 \| Tessier facial cleft \| 1 HP:0006323 \| Premature loss of baby teeth \| 1 HP:0000674 \| Anodontia \| 1

Disease ID	1481
Disease	root resorption
Manually Symptom	(Waiting for update.)
Text Mined Symptom	UMLS \| Name \| Sentences' Count(Total Symptoms:2) C0426768 \| o sign \| 8 C0029440 \| osteoma \| 1

Manually Genotype(Total Text Mining Genotypes:0)
(Waiting for update.)

All Snps(Total Genotypes:2)
snpId	pubmedId	geneId	geneSymbol	diseaseId	sourceId	sentence	score	Year	geneSymbol_dbSNP	CHROMOSOME	POS	REF	ALT
rs11730582	23614633	6696	SPP1	umls:C0035851	BeFree	Osteopontin gene SNPs (rs9138, rs11730582) mediate susceptibility to external root resorption in orthodontic patients.	0.000271442	2013	SPP1	4	87975269	T	C
rs9138	23614633	6696	SPP1	umls:C0035851	BeFree	Osteopontin gene SNPs (rs9138, rs11730582) mediate susceptibility to external root resorption in orthodontic patients.	0.000271442	2013	SPP1	4	87983190	A	C

GWASdb Annotation(Total Genotypes:0)
(Waiting for update.)

GWASdb Snp Trait(Total Genotypes:0)
(Waiting for update.)

Mapped by lexical matching(Total Items:0)
(Waiting for update.)

Mapped by homologous gene(Total Items:0)
(Waiting for update.)

Chemical(Total Drugs:0)
(Waiting for update.)

FDA approved drug and dosage information(Total Drugs:0)
(Waiting for update.)

FDA labeling changes(Total Drugs:0)
(Waiting for update.)

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