PedAM

Pediatric Disease Annotations & Medicines


	rheumatic fever

Disease ID	641
Disease	rheumatic fever
Definition	A febrile disease occurring as a delayed sequela of infections with STREPTOCOCCUS PYOGENES. It is characterized by multiple focal inflammatory lesions of the connective tissue structures, such as the heart, blood vessels, and joints (POLYARTHRITIS) and brain, and by the presence of ASCHOFF BODIES in the myocardium and skin.
Synonym	active rheumatic fever active rheumatic fever (disorder) acute articular rheumatism acute articular rheumatisms acute rheumatic arthritides acute rheumatic arthritis acute rheumatic arthritis (disorder) acute rheumatic attack acute rheumatic fever acute rheumatic fever (disorder) acute rheumatic fever nos acute rheumatic fever nos (disorder) acute rheumatic fevers acute rheumatism arf - acute rheumatic fever arthritides, acute rheumatic arthritis, acute rheumatic arthritis, rheumatic, acute articular rheumatism, acute articular rheumatisms, acute fever, acute rheumatic fever, rheumatic fevers, acute rheumatic fevers, rheumatic polyarthritis rheumatica polyarthritis rheumaticas rheumatic arthritides, acute rheumatic arthritis rheumatic arthritis acute rheumatic arthritis, acute rheumatic fever (disorder) rheumatic fever [disease/finding] rheumatic fever, active rheumatic fever, acute rheumatic fever, nos rheumatic fevers rheumatic fevers, acute rheumatism acute rheumatism, acute articular rheumatism, articular, acute rheumatism, inflammatory rheumatisms, acute articular rhf - rheumatic fever
Orphanet	ORPHANET:3099
DOID	DOID:1586
UMLS	C0035436
MeSH	D012213
SNOMED-CT	SNOMEDCT_US_2016_09_01:26424001;SNOMEDCT_US_2016_09_01:81077008;SNOMEDCT_US_2016_09_01:58718002
Comorbidity	UMLS \| Disease \| Sentences' Count(Total Sentences:31) C0018799 \| heart disease \| 5 C0035439 \| rheumatic heart disease \| 4 C0026269 \| mitral stenosis \| 3 C0003864 \| arthritis \| 2 C0017658 \| glomerulonephritis \| 2 C0085278 \| antiphospholipid syndrome \| 2 C0020538 \| hypertension \| 2 C0003507 \| aortic stenosis \| 1 C0014070 \| encephalomyelitis \| 1 C0028754 \| obesity \| 1 C0004352 \| autism \| 1 C0403414 \| post-streptococcal glomerulonephritis \| 1 C0036689 \| streptococcal pharyngitis \| 1 C0031350 \| pharyngitis \| 1 C0027059 \| myocarditis \| 1 C0004245 \| av block \| 1 C0014118 \| endocarditis \| 1 C0022116 \| ischaemia \| 1 C0018824 \| cardiac valvular disease \| 1 C0403414 \| acute post-streptococcal glomerulonephritis \| 1 C0029456 \| osteoporosis \| 1 C0031046 \| pericarditis \| 1 C0242429 \| sore throat \| 1 C0042769 \| viral infection \| 1 C0013395 \| dyspepsia \| 1 C0152113 \| sydenham's chorea \| 1 C0264766 \| rheumatic mitral stenosis \| 1 C0042769 \| viral infections \| 1 C0020542 \| pulmonary hypertension \| 1 C0031099 \| periodontitis \| 1 C0014059 \| acute disseminated encephalomyelitis \| 1
Curated Gene	(Waiting for update.)
Inferring Gene	Entrez_id \| Symbol \| Resource(Total Genes:7) 2212 \| FCGR2A \| infer 2215 \| FCGR3B \| infer 3117 \| HLA-DQA1 \| infer 3119 \| HLA-DQB1 \| infer 3123 \| HLA-DRB1 \| infer 7097 \| TLR2 \| infer 7124 \| TNF \| infer
Text Mined Gene	Entrez_id \| Symbol \| Score \| Resource(Total Genes:118) 4706 \| NDUFAB1 \| DISEASES 4335 \| MNT \| DISEASES 350 \| APOH \| DISEASES 4210 \| MEFV \| DISEASES 8797 \| TNFRSF10A \| DISEASES 973 \| CD79A \| DISEASES 727 \| C5 \| DISEASES 6346 \| CCL1 \| DISEASES 173 \| AFM \| DISEASES 3558 \| IL2 \| DISEASES 4598 \| MVK \| DISEASES 2597 \| GAPDH \| DISEASES 3565 \| IL4 \| DISEASES 6431 \| SRSF6 \| DISEASES 5199 \| CFP \| DISEASES 8930 \| MBD4 \| DISEASES 47 \| ACLY \| DISEASES 6737 \| TRIM21 \| DISEASES 1401 \| CRP \| DISEASES 4678 \| NASP \| DISEASES 3569 \| IL6 \| DISEASES 3557 \| IL1RN \| DISEASES 55997 \| CFC1 \| DISEASES 7097 \| TLR2 \| DISEASES 4069 \| LYZ \| DISEASES 9172 \| MYOM2 \| DISEASES 9739 \| SETD1A \| DISEASES 3249 \| HPN \| DISEASES 11043 \| MID2 \| DISEASES 3552 \| IL1A \| DISEASES 55717 \| WDR11 \| DISEASES 3574 \| IL7 \| DISEASES 5443 \| POMC \| DISEASES 3383 \| ICAM1 \| DISEASES 10058 \| ABCB6 \| DISEASES 1039 \| CDR2 \| DISEASES 150094 \| SIK1 \| DISEASES 8547 \| FCN3 \| DISEASES 375 \| ARF1 \| DISEASES 133 \| ADM \| DISEASES 738 \| VPS51 \| DISEASES 220134 \| SKA1 \| DISEASES 2220 \| FCN2 \| DISEASES 213 \| ALB \| DISEASES 2921 \| CXCL3 \| DISEASES 5648 \| MASP1 \| DISEASES 123169 \| LEO1 \| DISEASES 2923 \| PDIA3 \| DISEASES 136647 \| MPLKIP \| DISEASES 56246 \| MRAP \| DISEASES 10238 \| DCAF7 \| DISEASES 5340 \| PLG \| DISEASES 3964 \| LGALS8 \| DISEASES 9024 \| BRSK2 \| DISEASES 10290 \| SPEG \| DISEASES 4179 \| CD46 \| DISEASES 767 \| CA8 \| DISEASES 1960 \| EGR3 \| DISEASES 221150 \| SKA3 \| DISEASES 4312 \| MMP1 \| DISEASES 23660 \| ZKSCAN5 \| DISEASES 8227 \| AKAP17A \| DISEASES 55763 \| EXOC1 \| DISEASES 51218 \| GLRX5 \| DISEASES 83733 \| SLC25A18 \| DISEASES 926 \| CD8B \| DISEASES 348235 \| SKA2 \| DISEASES 2152 \| F3 \| DISEASES 1908 \| EDN3 \| DISEASES 64359 \| NXN \| DISEASES 78989 \| COLEC11 \| DISEASES 3117 \| HLA-DQA1 \| DISEASES 29102 \| DROSHA \| DISEASES 3329 \| HSPD1 \| DISEASES 7137 \| TNNI3 \| DISEASES 6227 \| RPS21 \| DISEASES 57591 \| MKL1 \| DISEASES 3240 \| HP \| DISEASES 219844 \| HYLS1 \| DISEASES 6651 \| SON \| DISEASES 26136 \| TES \| DISEASES 9179 \| AP4M1 \| DISEASES 3123 \| HLA-DRB1 \| DISEASES 56955 \| MEPE \| DISEASES 6993 \| DYNLT1 \| DISEASES 7139 \| TNNT2 \| DISEASES 23443 \| SLC35A3 \| DISEASES 959 \| CD40LG \| DISEASES 6005 \| RHAG \| DISEASES 2219 \| FCN1 \| DISEASES 4153 \| MBL2 \| DISEASES 3105 \| HLA-A \| DISEASES 8718 \| TNFRSF25 \| DISEASES 3559 \| IL2RA \| DISEASES 415 \| ARSE \| DISEASES 94 \| ACVRL1 \| DISEASES 284217 \| LAMA1 \| DISEASES 250 \| ALPP \| DISEASES 80196 \| RNF34 \| DISEASES 3119 \| HLA-DQB1 \| DISEASES 10747 \| MASP2 \| DISEASES 3778 \| KCNMA1 \| DISEASES 55660 \| PRPF40A \| DISEASES 10989 \| IMMT \| DISEASES 3120 \| HLA-DQB2 \| DISEASES 1029 \| CDKN2A \| DISEASES 55683 \| KANSL3 \| DISEASES 7124 \| TNF \| DISEASES 3106 \| HLA-B \| DISEASES 3586 \| IL10 \| DISEASES 721 \| C4B \| DISEASES 27042 \| DIEXF \| DISEASES 8801 \| SUCLG2 \| DISEASES 2638 \| GC \| DISEASES 930 \| CD19 \| DISEASES 11331 \| PHB2 \| DISEASES 6234 \| RPS28 \| DISEASES 100128252 \| ZNF667-AS1 \| DISEASES
Locus	(Waiting for update.)

Disease ID	641
Disease	rheumatic fever
Integrated Phenotype	HPO \| Name(Total Integrated Phenotypes:36) HP:0011675 \| Arrhythmia HP:0002380 \| Fasciculations HP:0002829 \| Arthralgia HP:0012733 \| Macule HP:0000980 \| Pallor HP:0010526 \| Dysgraphia HP:0010522 \| Dyslexia HP:0002019 \| Constipation HP:0000708 \| Behavioral abnormality HP:0002103 \| Abnormality of the pleura HP:0001633 \| Abnormality of the mitral valve HP:0100584 \| Endocarditis HP:0001945 \| Fever HP:0001654 \| Abnormality of the heart valves HP:0002093 \| Respiratory insufficiency HP:0000246 \| Sinusitis HP:0100776 \| Recurrent pharyngitis HP:0100248 \| Hemiballismus HP:0100749 \| Chest pain HP:0000100 \| Nephrotic syndrome HP:0010318 \| Aplasia/Hypoplasia of the abdominal wall musculature HP:0012378 \| Fatigue HP:0000421 \| Epistaxis HP:0002167 \| Neurological speech impairment HP:0001369 \| Arthritis HP:0001701 \| Pericarditis HP:0002017 \| Nausea and vomiting HP:0002072 \| Chorea HP:0012819 \| Myocarditis HP:0001646 \| Abnormality of the aortic valve HP:0002039 \| Anorexia HP:0001482 \| Subcutaneous nodule HP:0002027 \| Abdominal pain HP:0002076 \| Migraine HP:0001288 \| Gait disturbance HP:0010783 \| Erythema
Text Mined Phenotype	HPO \| Name \| Sentences' Count(Total Phenotypes:22) HP:0001718 \| Mitral stenosis \| 3 HP:0001369 \| Arthritis \| 2 HP:0012531 \| Pain \| 2 HP:0000822 \| Hypertension \| 2 HP:0000099 \| Glomerular nephritis \| 2 HP:0000717 \| Autism \| 1 HP:0100584 \| Endocarditis \| 1 HP:0002092 \| Pulmonary artery hypertension \| 1 HP:0001709 \| Complete heart block \| 1 HP:0012819 \| Myocarditis \| 1 HP:0100806 \| Sepsis \| 1 HP:0001513 \| Obesity \| 1 HP:0012722 \| Heart block \| 1 HP:0002072 \| Chorea \| 1 HP:0005110 \| Atrial fibrillation \| 1 HP:0200025 \| Mandibular pain \| 1 HP:0001650 \| Valvular aortic stenosis \| 1 HP:0000939 \| Osteoporosis \| 1 HP:0000707 \| Neurological abnormality \| 1 HP:0000704 \| Pyorrhea \| 1 HP:0001701 \| Pericarditis \| 1 HP:0100749 \| Thoracic pain \| 1

Disease ID	641
Disease	rheumatic fever
Manually Symptom	(Waiting for update.)
Text Mined Symptom	UMLS \| Name \| Sentences' Count(Total Symptoms:9) C0869523 \| carditis \| 7 C0009450 \| infection \| 4 C0018799 \| heart disease \| 2 C0003864 \| arthritis \| 2 C0027059 \| myocarditis \| 1 C0038395 \| streptococcal infections \| 1 C0008489 \| chorea \| 1 C0752303 \| urological manifestation \| 1 C0042769 \| viral infection \| 1

Manually Genotype(Total Text Mining Genotypes:0)
(Waiting for update.)

All Snps(Total Genotypes:2)
snpId	pubmedId	geneId	geneSymbol	diseaseId	sourceId	sentence	score	Year	geneSymbol_dbSNP	CHROMOSOME	POS	REF	ALT
rs5743708	15968536	7097	TLR2	umls:C0035436	BeFree	TLR-2 gene Arg753Gln polymorphism is strongly associated with acute rheumatic fever in children.	0.005634266	2005	TLR2	4	153705165	G	A
rs5743708	19693643	7097	TLR2	umls:C0035436	BeFree	Toll-like receptor 2 (TLR2) has been known to recognize several microbial antigens including that of streptococci, and TLR2 gene Arg753Gln polymorphism has been reported to be strongly associated with acute rheumatic fever with an odds ratio of 100.	0.005634266	2009	TLR2	4	153705165	G	A

GWASdb Annotation(Total Genotypes:0)
(Waiting for update.)

GWASdb Snp Trait(Total Genotypes:0)
(Waiting for update.)

Mapped by lexical matching(Total Items:0)
(Waiting for update.)

Mapped by homologous gene(Total Items:0)
(Waiting for update.)

Chemical(Total Drugs:1)
CUI	ChemicalName	ChemicalID	CasRN	DiseaseName	DiseaseID	DirectEvidence	PubMedIDs
C0035436	methotrexate	D008727	1959/5/2	rheumatic fever	MESH:D012213	therapeutic	16639489

FDA approved drug and dosage information(Total Drugs:0)
(Waiting for update.)

FDA labeling changes(Total Drugs:0)
(Waiting for update.)

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