PedAM

Pediatric Disease Annotations & Medicines


	reye syndrome

Disease ID	445
Disease	reye syndrome
Definition	A form of encephalopathy with fatty infiltration of the LIVER, characterized by brain EDEMA and VOMITING that may rapidly progress to SEIZURES; COMA; and DEATH. It is caused by a generalized loss of mitochondrial function leading to disturbances in fatty acid and CARNITINE metabolism.
Synonym	fatty liver with encephalopathy reye 's syndrome reye johnson syndrome reye syndrome [disease/finding] reye's encephalopathy reye's syndrome reye's syndrome (disorder) reye-johnson syndrome reyes syndrome reyes syndromes reyes's syndrome syndrome reye syndrome reyes
Orphanet	ORPHANET:3096
DOID	DOID:14525
ICD10	ICD10CM:G93.7
UMLS	C0035400
MeSH	D012202
SNOMED-CT	SNOMEDCT_US_2016_09_01:74351001
Comorbidity	UMLS \| Disease \| Sentences' Count(Total Sentences:2) C0878544 \| cardiomyopathy \| 1 C0014070 \| encephalomyelitis \| 1
Curated Gene	(Waiting for update.)
Inferring Gene	(Waiting for update.)
Text Mined Gene	Entrez_id \| Symbol \| Score \| Resource(Total Genes:78) 5009 \| OTC \| DISEASES 25776 \| CBY1 \| DISEASES 4967 \| OGDH \| DISEASES 4790 \| NFKB1 \| DISEASES 4055 \| LTBR \| DISEASES 4848 \| CNOT2 \| DISEASES 2026 \| ENO2 \| DISEASES 6908 \| TBP \| DISEASES 33 \| ACADL \| DISEASES 7276 \| TTR \| DISEASES 6584 \| SLC22A5 \| DISEASES 5199 \| CFP \| DISEASES 29108 \| PYCARD \| DISEASES 3630 \| INS \| DISEASES 29775 \| CARD10 \| DISEASES 10599 \| SLCO1B1 \| DISEASES 27141 \| CIDEB \| DISEASES 898 \| CCNE1 \| DISEASES 330 \| BIRC3 \| DISEASES 5775 \| PTPN4 \| DISEASES 89884 \| LHX4 \| DISEASES 6507 \| SLC1A3 \| DISEASES 1374 \| CPT1A \| DISEASES 5286 \| PIK3C2A \| DISEASES 8996 \| NOL3 \| DISEASES 6506 \| SLC1A2 \| DISEASES 5903 \| RANBP2 \| DISEASES 23250 \| ATP11A \| DISEASES 60675 \| PROK2 \| DISEASES 213 \| ALB \| DISEASES 11067 \| C10orf10 \| DISEASES 375611 \| SLC26A5 \| DISEASES 2147 \| F2 \| DISEASES 3661 \| IRF3 \| DISEASES 1375 \| CPT1B \| DISEASES 28976 \| ACAD9 \| DISEASES 2 \| A2M \| DISEASES 1555 \| CYP2B6 \| DISEASES 706 \| TSPO \| DISEASES 1743 \| DLST \| DISEASES 3988 \| LIPA \| DISEASES 1576 \| CYP3A4 \| DISEASES 3266 \| ERAS \| DISEASES 1431 \| CS \| DISEASES 31 \| ACACA \| DISEASES 987 \| LRBA \| DISEASES 1612 \| DAPK1 \| DISEASES 6364 \| CCL20 \| DISEASES 4512 \| MT-CO1 \| DISEASES 4519 \| MT-CYB \| DISEASES 4508 \| MT-ATP6 \| DISEASES 4513 \| MT-CO2 \| DISEASES 4514 \| MT-CO3 \| DISEASES 23038 \| WDTC1 \| DISEASES 10628 \| TXNIP \| DISEASES 840 \| CASP7 \| DISEASES 2805 \| GOT1 \| DISEASES 959 \| CD40LG \| DISEASES 1647 \| GADD45A \| DISEASES 1376 \| CPT2 \| DISEASES 9968 \| MED12 \| DISEASES 3155 \| HMGCL \| DISEASES 7295 \| TXN \| DISEASES 229 \| ALDOB \| DISEASES 3376 \| IARS \| DISEASES 3030 \| HADHA \| DISEASES 6649 \| SOD3 \| DISEASES 4155 \| MBP \| DISEASES 23410 \| SIRT3 \| DISEASES 3426 \| CFI \| DISEASES 3033 \| HADH \| DISEASES 279 \| AMY2A \| DISEASES 4049 \| LTA \| DISEASES 34 \| ACADM \| DISEASES 6256 \| RXRA \| DISEASES 2110 \| ETFDH \| DISEASES 4558 \| MT-TF \| DISEASES 4566 \| MT-TK \| DISEASES
Locus	(Waiting for update.)

Disease ID	445
Disease	reye syndrome
Integrated Phenotype	(Waiting for update.)
Text Mined Phenotype	HPO \| Name \| Sentences' Count(Total Phenotypes:4) HP:0001298 \| Encephalopathy \| 1 HP:0001399 \| Liver failure \| 1 HP:0001638 \| Cardiomyopathy \| 1 HP:0011675 \| Arrhythmias \| 1

Disease ID	445
Disease	reye syndrome
Manually Symptom	UMLS \| Name(Total Manually Symptoms:9) C2364324 \| increased intracranial pressure C1963198 \| pancreatitis C1963101 \| encephalopathy C0151740 \| elevated intracranial pressure C0042769 \| viral infections C0037769 \| west syndrome C0022660 \| acute renal failure C0005779 \| coagulation defect C0002063 \| alkalosis
Text Mined Symptom	UMLS \| Name \| Sentences' Count(Total Symptoms:1) C0085584 \| encephalopathy \| 1

Manually Genotype(Total Text Mining Genotypes:0)
(Waiting for update.)

All Snps(Total Genotypes:0)
(Waiting for update.)

GWASdb Annotation(Total Genotypes:0)
(Waiting for update.)

GWASdb Snp Trait(Total Genotypes:0)
(Waiting for update.)

Mapped by lexical matching(Total Items:0)
(Waiting for update.)

Mapped by homologous gene(Total Items:0)
(Waiting for update.)

Chemical(Total Drugs:2)
CUI	ChemicalName	ChemicalID	CasRN	DiseaseName	DiseaseID	DirectEvidence	PubMedIDs
C0035400	diclofenac	D004008	15307-86-5	reye syndrome	MESH:D012202	marker/mechanism	9379106
C0035400	valproic acid	D014635	99-66-1	reye syndrome	MESH:D012202	marker/mechanism	6819143

FDA approved drug and dosage information(Total Drugs:0)
(Waiting for update.)

FDA labeling changes(Total Drugs:0)
(Waiting for update.)

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