PedAM

Pediatric Disease Annotations & Medicines


	retinal artery occlusion

Disease ID	1127
Disease	retinal artery occlusion
Definition	Sudden ISCHEMIA in the RETINA due to blocked blood flow through the CENTRAL RETINAL ARTERY or its branches leading to sudden complete or partial loss of vision, respectively, in the eye.
Synonym	artery occlusion retinal occlusion retinal artery occlusion, retinal artery occlusions, retinal artery rao - retinal artery occlusion retinal artery occlusion (disorder) retinal artery occlusion [disease/finding] retinal artery occlusions
DOID	DOID:8483
UMLS	C0035302
MeSH	D015356
SNOMED-CT	SNOMEDCT_US_2016_09_01:232035005
Comorbidity	UMLS \| Disease \| Sentences' Count(Total Sentences:60) C0035328 \| retinal vein occlusion \| 7 C0456909 \| blindness \| 5 C0154841 \| central retinal vein occlusion \| 5 C0456909 \| vision loss \| 4 C0035309 \| retinopathy \| 3 C0547030 \| visual disturbance \| 3 C0022116 \| ischemia \| 3 C0042384 \| vasculitis \| 3 C0547030 \| visual disturbances \| 3 C0152026 \| retinal vasculitis \| 2 C0016522 \| patent foramen ovale \| 2 C0008728 \| churg-strauss syndrome \| 2 C0149507 \| orbital cellulitis \| 2 C0409974 \| lupus erythematosus \| 2 C0024141 \| systemic lupus erythematosus \| 2 C0442874 \| neuropathy \| 2 C0029132 \| optic neuropathy \| 2 C0035305 \| retinal detachment \| 2 C0007642 \| cellulitis \| 2 C0040053 \| thrombosis \| 1 C0154916 \| iris neovascularization \| 1 C0017601 \| glaucoma \| 1 C0271051 \| macular edema \| 1 C0042167 \| posterior uveitis \| 1 C0154874 \| neuroretinitis \| 1 C0154830 \| proliferative diabetic retinopathy \| 1 C0027051 \| myocardial infarct \| 1 C0027051 \| myocardial infarction \| 1 C0151311 \| cranial nerve palsy \| 1 C0751711 \| anterior ischemic optic neuropathy \| 1 C0019348 \| herpes simplex \| 1 C0002895 \| sickle cell disease \| 1 C0007785 \| cerebral infarction \| 1 C0524620 \| metabolic syndrome x \| 1 C0007222 \| cardiovascular disease \| 1 C0007785 \| cerebral infarct \| 1 C0742472 \| central nervous system lymphoma \| 1 C0008728 \| churg-strauss vasculitis \| 1 C0043092 \| wegener's granulomatosis \| 1 C0011884 \| diabetic retinopathy \| 1 C0042164 \| uveitis \| 1 C0040561 \| ocular toxoplasmosis \| 1 C0155626 \| acute mi \| 1 C0016052 \| fibromuscular dysplasia \| 1 C0042373 \| vascular disease \| 1 C0155626 \| acute myocardial infarction \| 1 C0024440 \| cystoid macular edema \| 1 C0282492 \| sneddon's syndrome \| 1 C0085278 \| antiphospholipid antibody syndrome \| 1 C0039445 \| hereditary hemorrhagic telangiectasia \| 1 C0035319 \| acute retinal necrosis \| 1 C0007361 \| cat-scratch disease \| 1 C0155765 \| microangiopathy \| 1 C0039446 \| telangiectasia \| 1 C0011847 \| diabetes \| 1 C0017205 \| gaucher disease \| 1 C0242420 \| retinal edema \| 1 C0948265 \| metabolic syndrome \| 1 C0007282 \| carotid stenosis \| 1 C0004943 \| behcet disease \| 1
Curated Gene	(Waiting for update.)
Inferring Gene	Entrez_id \| Symbol \| Resource(Total Genes:3) 2153 \| F5 \| infer 2157 \| F8 \| infer 3586 \| IL10 \| infer
Text Mined Gene	Entrez_id \| Symbol \| Score \| Resource(Total Genes:59) 5662 \| PSD \| DISEASES 3162 \| HMOX1 \| DISEASES 140679 \| SLC32A1 \| DISEASES 5327 \| PLAT \| DISEASES 57030 \| SLC17A7 \| DISEASES 5657 \| PRTN3 \| DISEASES 1401 \| CRP \| DISEASES 759 \| CA1 \| DISEASES 29113 \| C6orf15 \| DISEASES 25833 \| POU2F3 \| DISEASES 6741 \| SSB \| DISEASES 51156 \| SERPINA10 \| DISEASES 57084 \| SLC17A6 \| DISEASES 3004 \| GZMM \| DISEASES 6652 \| SORD \| DISEASES 340348 \| TSPAN33 \| DISEASES 581 \| BAX \| DISEASES 2244 \| FGB \| DISEASES 2147 \| F2 \| DISEASES 5340 \| PLG \| DISEASES 1604 \| CD55 \| DISEASES 246213 \| SLC17A8 \| DISEASES 27436 \| EML4 \| DISEASES 2152 \| F3 \| DISEASES 3091 \| HIF1A \| DISEASES 966 \| CD59 \| DISEASES 404552 \| SCGB1D4 \| DISEASES 56980 \| PRDM10 \| DISEASES 4133 \| MAP2 \| DISEASES 6905 \| TBCE \| DISEASES 462 \| SERPINC1 \| DISEASES 5824 \| PEX19 \| DISEASES 55974 \| SLC50A1 \| DISEASES 6098 \| ROS1 \| DISEASES 8266 \| UBL4A \| DISEASES 959 \| CD40LG \| DISEASES 26036 \| ZNF451 \| DISEASES 1791 \| DNTT \| DISEASES 9211 \| LGI1 \| DISEASES 7422 \| VEGFA \| DISEASES 4303 \| FOXO4 \| DISEASES 199 \| AIF1 \| DISEASES 4524 \| MTHFR \| DISEASES 2189 \| FANCG \| DISEASES 1906 \| EDN1 \| DISEASES 3717 \| JAK2 \| DISEASES 114899 \| C1QTNF3 \| DISEASES 124220 \| ZG16B \| DISEASES 2160 \| F11 \| DISEASES 91833 \| WDR20 \| DISEASES 2876 \| GPX1 \| DISEASES 7555 \| CNBP \| DISEASES 10687 \| PNMA2 \| DISEASES 7178 \| TPT1 \| DISEASES 3347 \| HTN3 \| DISEASES 26298 \| EHF \| DISEASES 83695 \| RHNO1 \| DISEASES 5027 \| P2RX7 \| DISEASES 102723508 \| KANTR \| DISEASES
Locus	(Waiting for update.)

Disease ID	1127
Disease	retinal artery occlusion
Integrated Phenotype	(Waiting for update.)
Text Mined Phenotype	HPO \| Name \| Sentences' Count(Total Phenotypes:34) HP:0000572 \| Visual loss \| 8 HP:0012636 \| Retinal vein occlusion \| 7 HP:0000618 \| Blindness \| 5 HP:0002633 \| Vasculitis \| 3 HP:0000488 \| Noninflammatory retina disease \| 3 HP:0000969 \| Dropsy \| 3 HP:0001655 \| Patent foramen ovale \| 2 HP:0000541 \| Detached retina \| 2 HP:0002725 \| Systemic lupus erythematosus \| 2 HP:0001138 \| Damaged optic nerve \| 2 HP:0001636 \| Tetrology of fallot \| 1 HP:0011497 \| New blood vessel formation in iris \| 1 HP:0030069 \| Primary central nervous system lymphoma \| 1 HP:0006846 \| Acute encephalopathy \| 1 HP:0000505 \| Poor vision \| 1 HP:0003613 \| Antiphospholipid antibodies \| 1 HP:0100658 \| Bacterial infection of skin \| 1 HP:0100735 \| Hypertensive crisis \| 1 HP:0001660 \| Common arterial trunk \| 1 HP:0000501 \| Glaucoma \| 1 HP:0012123 \| Posterior uveitis \| 1 HP:0001298 \| Encephalopathy \| 1 HP:0030666 \| Retinal neovascularisation \| 1 HP:0100546 \| Narrowing of carotid artery \| 1 HP:0011505 \| Cystoid macular edema \| 1 HP:0006824 \| Cranial nerve palsy \| 1 HP:0040049 \| Macular edema \| 1 HP:0011531 \| Hyalitis \| 1 HP:0002955 \| Granulomatosis \| 1 HP:0001658 \| Myocardial infarction \| 1 HP:0001009 \| Telangiectases \| 1 HP:0000554 \| Uveitis \| 1 HP:0000597 \| Ophthalmoparesis \| 1 HP:0007866 \| Retinal infarction \| 1

Disease ID	1127
Disease	retinal artery occlusion
Manually Symptom	(Waiting for update.)
Text Mined Symptom	UMLS \| Name \| Sentences' Count(Total Symptoms:2) C0002895 \| sickle cell disease \| 1 C0751711 \| anterior ischemic optic neuropathy \| 1

Manually Genotype(Total Text Mining Genotypes:0)
(Waiting for update.)

All Snps(Total Genotypes:0)
(Waiting for update.)

GWASdb Annotation(Total Genotypes:0)
(Waiting for update.)

GWASdb Snp Trait(Total Genotypes:0)
(Waiting for update.)

Mapped by lexical matching(Total Items:0)
(Waiting for update.)

Mapped by homologous gene(Total Items:0)
(Waiting for update.)

Chemical(Total Drugs:4)
CUI	ChemicalName	ChemicalID	CasRN	DiseaseName	DiseaseID	DirectEvidence	PubMedIDs
C0035302	carmustine	D002330	154-93-8	retinal artery occlusion	MESH:D015356	marker/mechanism	11020424
C0035302	cisplatin	D002945	15663-27-1	retinal artery occlusion	MESH:D015356	marker/mechanism	11020424
C0035302	mitomycin	D016685	1950/7/7	retinal artery occlusion	MESH:D015356	marker/mechanism	7852024
C0035302	tranexamic acid	D014148	1197-18-8	retinal artery occlusion	MESH:D015356	marker/mechanism	9033905

FDA approved drug and dosage information(Total Drugs:1)
DiseaseID	Drug_name	active_ingredients	strength	Dosage Form/Route	Marketing Status	TE code	RLD	RS
MESH:D015356	lysteda	tranexamic acid	650MG	TABLET;ORAL	Prescription	AB	Yes	Yes

FDA labeling changes(Total Drugs:1)
DiseaseID	Pediatric_Labeling_Date	Trade_Name	Generic_Name_or_Proper_Name	Indications Studied	Label Changes Summary	Product Labeling	BPCA(B)	PREA(P)	BPCA(B) and PREA(P)	Pediatric Rule (R)	Sponsor	Pediatric Exclusivity Granted Date	NNPS
MESH:D015356	08/21/2013	lysteda	tranexamic acid	Treatment of cyclic heavy menstrual bleeding	Indicated for women of reproductive age. It is not intended for use in premenarcheal girls Information on PK studyPostmarketing study	-	P	-	-	Ferring	-	FALSE'	-

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