PedAM

Pediatric Disease Annotations & Medicines


	respiratory syncytial virus infection

Disease ID	1275
Disease	respiratory syncytial virus infection
Definition	Pneumovirus infections caused by the RESPIRATORY SYNCYTIAL VIRUSES. Humans and cattle are most affected but infections in goats and sheep have been reported.
Synonym	infect respiratory syncytial virus infection rsv infections, respiratory syncytial virus respiratory syncytial virus infect respiratory syncytial virus infection (disorder) respiratory syncytial virus infection, nos respiratory syncytial virus infections respiratory syncytial virus infections [disease/finding] respiratory tract, syncytial virus infection rsv - respiratory syncytial virus infection rsv infection rsv infections
UMLS	C0035235
MeSH	D018357
SNOMED-CT	SNOMEDCT_US_2016_09_01:55735004
Comorbidity	UMLS \| Disease \| Sentences' Count(Total Sentences:8) C0010674 \| cystic fibrosis \| 4 C0152021 \| congenital heart disease \| 2 C0018799 \| heart disease \| 2 C0004096 \| asthma \| 1 C0006017 \| pertussis \| 1 C0085669 \| acute leukemia \| 1 C0006271 \| bronchiolitis \| 1 C0024115 \| lung disease \| 1
Curated Gene	Entrez_id \| Symbol \| Resource(Total Genes:5) ICAM1 \| 3383 \| CTD_human IFNG \| 3458 \| CTD_human TICAM1 \| 148022 \| CTD_human PDE12 \| 201626 \| CTD_human SARM1 \| 23098 \| CTD_human
Inferring Gene	Entrez_id \| Symbol \| Resource(Total Genes:18) 653509 \| SFTPA1 \| infer 6441 \| SFTPD \| infer 3429 \| IFI27 \| infer 10561 \| IFI44 \| infer 3442 \| IFNA5 \| infer 3454 \| IFNAR1 \| infer 3458 \| IFNG \| infer 3459 \| IFNGR1 \| infer 3606 \| IL18 \| infer 9636 \| ISG15 \| infer 7096 \| TLR1 \| infer 81793 \| TLR10 \| infer 7097 \| TLR2 \| infer 7098 \| TLR3 \| infer 7099 \| TLR4 \| infer 7100 \| TLR5 \| infer 10333 \| TLR6 \| infer 54106 \| TLR9 \| infer
Text Mined Gene	(Waiting for update.)
Locus	(Waiting for update.)

Disease ID	1275
Disease	respiratory syncytial virus infection
Integrated Phenotype	(Waiting for update.)
Text Mined Phenotype	HPO \| Name \| Sentences' Count(Total Phenotypes:10) HP:0030828 \| Wheezing \| 2 HP:0002373 \| Febrile convulsions \| 1 HP:0001663 \| Ventricular fibrillation \| 1 HP:0001250 \| Seizures \| 1 HP:0001298 \| Encephalopathy \| 1 HP:0011950 \| Bronchiolitis \| 1 HP:0006846 \| Acute encephalopathy \| 1 HP:0002488 \| Acute leukemias \| 1 HP:0005948 \| Cystic lung disease \| 1 HP:0002099 \| Asthma \| 1

Disease ID	1275
Disease	respiratory syncytial virus infection
Manually Symptom	(Waiting for update.)
Text Mined Symptom	UMLS \| Name \| Sentences' Count(Total Symptoms:1) C0006271 \| bronchiolitis \| 1

Manually Genotype(Total Text Mining Genotypes:0)
(Waiting for update.)

All Snps(Total Genotypes:14)
snpId	pubmedId	geneId	geneSymbol	diseaseId	sourceId	sentence	score	Year	geneSymbol_dbSNP	CHROMOSOME	POS	REF	ALT
rs16850073	20503287	6372	CXCL6	umls:C0035235	GAD	[Interleukin-9 polymorphism in infants with respiratory syncytial virus infection: an opposite effect in boys and girls.]	0.004734064	2010	CXCL6	4	73838282	C	T
rs2069885	20503287	3578	IL9	umls:C0035235	GAD	[Interleukin-9 polymorphism in infants with respiratory syncytial virus infection: an opposite effect in boys and girls.]	0.005005506	2010	IL9	5	135892476	G	A
rs2229170	20503287	6865	TACR2	umls:C0035235	GAD	[Interleukin-9 polymorphism in infants with respiratory syncytial virus infection: an opposite effect in boys and girls.]	0.004734064	2010	TACR2;LOC105378343	10	69404899	C	T
rs2233406	23487427	4792	NFKBIA	umls:C0035235	BeFree	In this study, we quantified the functional impact of NFKBIA promoter polymorphisms (rs3138053, rs2233406, and rs2233409) on promoter-driven protein expression, allele-specific and total NFKBIA mRNA expression, IκBα protein expression, and TLR responsiveness; mapped innate immune regulatory networks active during respiratory syncytial virus infection, asthma, and bronchopulmonary dysplasia; and genotyped and analyzed independent cohorts of children with respiratory syncytial virus infection, asthma, and bronchopulmonary dysplasia.	0.002638474	2013	NFKBIA	14	35405593	G	A
rs2233409	23487427	4792	NFKBIA	umls:C0035235	BeFree	In this study, we quantified the functional impact of NFKBIA promoter polymorphisms (rs3138053, rs2233406, and rs2233409) on promoter-driven protein expression, allele-specific and total NFKBIA mRNA expression, IκBα protein expression, and TLR responsiveness; mapped innate immune regulatory networks active during respiratory syncytial virus infection, asthma, and bronchopulmonary dysplasia; and genotyped and analyzed independent cohorts of children with respiratory syncytial virus infection, asthma, and bronchopulmonary dysplasia.	0.002638474	2013	NFKBIA	14	35405064	G	A
rs2259292	20503287	4585	MUC4	umls:C0035235	GAD	[Interleukin-9 polymorphism in infants with respiratory syncytial virus infection: an opposite effect in boys and girls.]	0.004734064	2010	MUC4	3	195774278	C	T
rs2293158	20503287	6776	STAT5A	umls:C0035235	GAD	[Interleukin-9 polymorphism in infants with respiratory syncytial virus infection: an opposite effect in boys and girls.]	0.004734064	2010	STAT5A	17	42295540	T	C
rs3091251	20503287	3001	GZMA	umls:C0035235	GAD	[Interleukin-9 polymorphism in infants with respiratory syncytial virus infection: an opposite effect in boys and girls.]	0.004734064	2010	GZMA	5	55109090	G	A
rs3116494	20503287	940	CD28	umls:C0035235	GAD	[Interleukin-9 polymorphism in infants with respiratory syncytial virus infection: an opposite effect in boys and girls.]	0.004734064	2010	CD28	2	203727298	G	A
rs3138053	23487427	4792	NFKBIA	umls:C0035235	BeFree	In this study, we quantified the functional impact of NFKBIA promoter polymorphisms (rs3138053, rs2233406, and rs2233409) on promoter-driven protein expression, allele-specific and total NFKBIA mRNA expression, IκBα protein expression, and TLR responsiveness; mapped innate immune regulatory networks active during respiratory syncytial virus infection, asthma, and bronchopulmonary dysplasia; and genotyped and analyzed independent cohorts of children with respiratory syncytial virus infection, asthma, and bronchopulmonary dysplasia.	0.002638474	2013	NFKBIA	14	35405648	T	C
rs3741240	20503287	7356	SCGB1A1	umls:C0035235	GAD	[Interleukin-9 polymorphism in infants with respiratory syncytial virus infection: an opposite effect in boys and girls.]	0.005005506	2010	SCGB1A1;LOC102723765	11	62419070	G	A
rs4148880	20503287	6890	TAP1	umls:C0035235	GAD	[Interleukin-9 polymorphism in infants with respiratory syncytial virus infection: an opposite effect in boys and girls.]	0.005005506	2010	NA	NA	NA	NA	NA
rs4251545	20503287	51135	IRAK4	umls:C0035235	GAD	[Interleukin-9 polymorphism in infants with respiratory syncytial virus infection: an opposite effect in boys and girls.]	0.004734064	2010	IRAK4	12	43786492	G	A
rs522616	22267765	4314	MMP3	umls:C0035235	BeFree	MMP-3 was confirmed as a marker of disease severity in a larger cohort and MMP3 gene polymorphism rs522616 was associated with severe RSV infection (OR 0.82, p<0.05).	0.000271442	2012	MMP3	11	102844317	T	C

GWASdb Annotation(Total Genotypes:0)
(Waiting for update.)

GWASdb Snp Trait(Total Genotypes:0)
(Waiting for update.)

Mapped by lexical matching(Total Items:0)
(Waiting for update.)

Mapped by homologous gene(Total Items:0)
(Waiting for update.)

Chemical(Total Drugs:2)
CUI	ChemicalName	ChemicalID	CasRN	DiseaseName	DiseaseID	DirectEvidence	PubMedIDs
C0035235	bortezomib	D000069286	-	respiratory syncytial virus infections	MESH:D018357	therapeutic	19931343
C0035235	ribavirin	D012254	36791-04-5	respiratory syncytial virus infections	MESH:D018357	therapeutic	11781627

FDA approved drug and dosage information(Total Drugs:0)
(Waiting for update.)

FDA labeling changes(Total Drugs:0)
(Waiting for update.)

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