PedAM
Pediatric Disease Annotations & Medicines
| renovascular hypertension | ||||
| Disease ID | 848 |
|---|---|
| Disease | renovascular hypertension |
| Integrated Phenotype | (Waiting for update.) |
| Text Mined Phenotype | HPO | Name | Sentences' Count(Total Phenotypes:15) HP:0001920 | Renal artery stenosis | 4 HP:0004953 | Abdominal aortic aneurysm | 1 HP:0004942 | Aortic aneurysm | 1 HP:0000086 | Ectopic kidney | 1 HP:0000752 | Hyperactive behavior | 1 HP:0000822 | Hypertension | 1 HP:0000100 | Nephrosis | 1 HP:0002315 | Headaches | 1 HP:0002459 | Dysautonomia | 1 HP:0100602 | Pre-eclampsia | 1 HP:0004417 | Intermittent claudication | 1 HP:0001959 | Polydipsia | 1 HP:0002902 | Hyponatremia | 1 HP:0000083 | Renal insufficiency | 1 HP:0002617 | Aneurysmal dilatation | 1 |
| Disease ID | 848 |
|---|---|
| Disease | renovascular hypertension |
| Manually Symptom | (Waiting for update.) |
| Text Mined Symptom | UMLS | Name | Sentences' Count(Total Symptoms:9) C0009814 | stenosis | 5 C0035067 | renal artery stenosis | 4 C0027726 | nephrotic syndrome | 1 C0026654 | moyamoya disease | 1 C0020625 | hyponatremia | 1 C0016052 | fibromuscular dysplasia | 1 C0852949 | arterial disease | 1 C0856169 | endothelial dysfunction | 1 C0162871 | abdominal aortic aneurysm | 1 |
Manually Genotype(Total Text Mining Genotypes:0) |
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| (Waiting for update.) |
All Snps(Total Genotypes:5) | |||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| snpId | pubmedId | geneId | geneSymbol | diseaseId | sourceId | sentence | score | Year | geneSymbol_dbSNP | CHROMOSOME | POS | REF | ALT |
| rs1799983 | 15326089 | 185 | AGTR1 | umls:C0020545 | BeFree | We investigated the association of polymorphisms in these genes (the angiotensinogen Met235Thr, the angiotensin-converting enzyme insertion/deletion, the angiotensin II type-1 receptor A1166C, and the eNOS Glu298Asp) with the presence or absence of atherosclerotic renovascular disease in 456 consecutive hypertensive patients referred for renal angiography on the suspicion of renovascular hypertension. | 0.080542884 | 2004 | NOS3 | 7 | 150999023 | T | G |
| rs1799983 | 15326089 | 4846 | NOS3 | umls:C0020545 | BeFree | We investigated the association of polymorphisms in these genes (the angiotensinogen Met235Thr, the angiotensin-converting enzyme insertion/deletion, the angiotensin II type-1 receptor A1166C, and the eNOS Glu298Asp) with the presence or absence of atherosclerotic renovascular disease in 456 consecutive hypertensive patients referred for renal angiography on the suspicion of renovascular hypertension. | 0.120271442 | 2004 | NOS3 | 7 | 150999023 | T | G |
| rs1799983 | 15326089 | 1636 | ACE | umls:C0020545 | BeFree | We investigated the association of polymorphisms in these genes (the angiotensinogen Met235Thr, the angiotensin-converting enzyme insertion/deletion, the angiotensin II type-1 receptor A1166C, and the eNOS Glu298Asp) with the presence or absence of atherosclerotic renovascular disease in 456 consecutive hypertensive patients referred for renal angiography on the suspicion of renovascular hypertension. | 0.080542884 | 2004 | NOS3 | 7 | 150999023 | T | G |
| rs198389 | 19413180 | 4879 | NPPB | umls:C0020545 | BeFree | We demonstrated the association between SNP rs198389 (T-381 C) polymorphism in the BNP gene promoter and the degree of RAS in patients with atherosclerotic renovascular hypertension. | 0.002638474 | 2009 | NPPB | 1 | 11859214 | A | G |
| rs198389 | 19413180 | 4879 | NPPB | umls:C0020545 | GAD | [We demonstrated the association between SNP rs198389 (T-381 C) polymorphism in the BNP gene promoter and the degree of RAS in patients with atherosclerotic renovascular hypertension.] | 0.002638474 | 2009 | NPPB | 1 | 11859214 | A | G |
GWASdb Annotation(Total Genotypes:0) | |
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| (Waiting for update.) | |
GWASdb Snp Trait(Total Genotypes:0) | |
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| (Waiting for update.) | |
Mapped by lexical matching(Total Items:0) |
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| (Waiting for update.) |
Mapped by homologous gene(Total Items:0) |
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| (Waiting for update.) |
Chemical(Total Drugs:7) | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| CUI | ChemicalName | ChemicalID | CasRN | DiseaseName | DiseaseID | DirectEvidence | PubMedIDs | ||
| C0020545 | amlodipine | D017311 | 88150-42-9 | hypertension, renovascular | MESH:D006978 | therapeutic | 14763026 | ||
| C0020545 | benazepril | C044946 | 86541-75-5 | hypertension, renovascular | MESH:D006978 | therapeutic | 14763026 | ||
| C0020545 | bleomycin | D001761 | 11056-06-7 | hypertension, renovascular | MESH:D006978 | marker/mechanism | 6181679 | ||
| C0020545 | clonidine | D003000 | 4205-90-7 | hypertension, renovascular | MESH:D006978 | therapeutic | 6337026 | ||
| C0020545 | cisplatin | D002945 | 15663-27-1 | hypertension, renovascular | MESH:D006978 | marker/mechanism | 6181679 | ||
| C0020545 | enalapril | D004656 | 75847-73-3 | hypertension, renovascular | MESH:D006978 | therapeutic | 1639466 | ||
| C0020545 | vinblastine | D014747 | 865-21-4 | hypertension, renovascular | MESH:D006978 | marker/mechanism | 6181679 | ||
FDA approved drug and dosage information(Total Drugs:0) | |
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| (Waiting for update.) | |
FDA labeling changes(Total Drugs:0) | |
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| (Waiting for update.) | |