PedAM

Pediatric Disease Annotations & Medicines


	renal hypertension

Disease ID	468
Disease	renal hypertension
Definition	Persistent high BLOOD PRESSURE due to KIDNEY DISEASES, such as those involving the renal parenchyma, the renal vasculature, or tumors that secrete RENIN.
Synonym	hypertension renal hypertension, renal hypertension, renal [disease/finding] hypertensions, renal renal hypertension (disorder) renal hypertensions
DOID	DOID:1073
UMLS	C0020544
MeSH	D006977
SNOMED-CT	SNOMEDCT_US_2016_09_01:28119000
Comorbidity	UMLS \| Disease \| Sentences' Count(Total Sentences:4) C0011847 \| diabetes \| 1 C0011860 \| type 2 diabetes \| 1 C0003850 \| arteriosclerosis \| 1 C0022116 \| ischaemia \| 1
Curated Gene	Entrez_id \| Symbol \| Resource(Total Genes:3) AGT \| 183 \| CTD_human MYH9 \| 4627 \| CTD_human NPPA \| 4878 \| CTD_human
Inferring Gene	Entrez_id \| Symbol \| Resource(Total Genes:8) 1636 \| ACE \| infer 183 \| AGT \| infer 185 \| AGTR1 \| infer 1559 \| CYP2C9 \| infer 1812 \| DRD1 \| infer 2868 \| GRK4 \| infer 9027 \| NAT8 \| infer 4846 \| NOS3 \| infer
Text Mined Gene	Entrez_id \| Symbol \| Score \| Resource(Total Genes:126) 1634 \| DCN \| DISEASES 3162 \| HMOX1 \| DISEASES 4627 \| MYH9 \| DISEASES 1113 \| CHGA \| DISEASES 4313 \| MMP2 \| DISEASES 3163 \| HMOX2 \| DISEASES 51285 \| RASL12 \| DISEASES 1666 \| DECR1 \| DISEASES 7040 \| TGFB1 \| DISEASES 973 \| CD79A \| DISEASES 5054 \| SERPINE1 \| DISEASES 6347 \| CCL2 \| DISEASES 2597 \| GAPDH \| DISEASES 84519 \| ACRBP \| DISEASES 8074 \| FGF23 \| DISEASES 4852 \| NPY \| DISEASES 10268 \| RAMP3 \| DISEASES 3630 \| INS \| DISEASES 2006 \| ELN \| DISEASES 348 \| APOE \| DISEASES 59272 \| ACE2 \| DISEASES 2056 \| EPO \| DISEASES 10343 \| PKDREJ \| DISEASES 1401 \| CRP \| DISEASES 187 \| APLNR \| DISEASES 3569 \| IL6 \| DISEASES 1295 \| COL8A1 \| DISEASES 4069 \| LYZ \| DISEASES 25939 \| SAMHD1 \| DISEASES 23523 \| CABIN1 \| DISEASES 50507 \| NOX4 \| DISEASES 390 \| RND3 \| DISEASES 5443 \| POMC \| DISEASES 3827 \| KNG1 \| DISEASES 1374 \| CPT1A \| DISEASES 85407 \| NKD1 \| DISEASES 5409 \| PNMT \| DISEASES 5972 \| REN \| DISEASES 388 \| RHOB \| DISEASES 23549 \| DNPEP \| DISEASES 185 \| AGTR1 \| DISEASES 275 \| AMT \| DISEASES 3779 \| KCNMB1 \| DISEASES 133 \| ADM \| DISEASES 5741 \| PTH \| DISEASES 29974 \| A1CF \| DISEASES 653361 \| NCF1 \| DISEASES 1636 \| ACE \| DISEASES 5739 \| PTGIR \| DISEASES 326 \| AIRE \| DISEASES 213 \| ALB \| DISEASES 9607 \| CARTPT \| DISEASES 4846 \| NOS3 \| DISEASES 57094 \| CPA6 \| DISEASES 27199 \| OXGR1 \| DISEASES 6249 \| CLIP1 \| DISEASES 7064 \| THOP1 \| DISEASES 8862 \| APLN \| DISEASES 51778 \| MYOZ2 \| DISEASES 8567 \| MADD \| DISEASES 8542 \| APOL1 \| DISEASES 53905 \| DUOX1 \| DISEASES 50619 \| DEF6 \| DISEASES 25898 \| RCHY1 \| DISEASES 1585 \| CYP11B2 \| DISEASES 9622 \| KLK4 \| DISEASES 387775 \| SLC22A10 \| DISEASES 51218 \| GLRX5 \| DISEASES 144453 \| BEST3 \| DISEASES 153571 \| C5orf38 \| DISEASES 1665 \| DHX15 \| DISEASES 8710 \| SERPINB7 \| DISEASES 4842 \| NOS1 \| DISEASES 4306 \| NR3C2 \| DISEASES 81551 \| STMN4 \| DISEASES 5154 \| PDGFA \| DISEASES 2873 \| GPS1 \| DISEASES 4624 \| MYH6 \| DISEASES 5733 \| PTGER3 \| DISEASES 26136 \| TES \| DISEASES 4763 \| NF1 \| DISEASES 6525 \| SMTN \| DISEASES 23085 \| ERC1 \| DISEASES 10724 \| MGEA5 \| DISEASES 56670 \| SUCNR1 \| DISEASES 183 \| AGT \| DISEASES 5743 \| PTGS2 \| DISEASES 8504 \| PEX3 \| DISEASES 7827 \| NPHS2 \| DISEASES 1490 \| CTGF \| DISEASES 153 \| ADRB1 \| DISEASES 4923 \| NTSR1 \| DISEASES 959 \| CD40LG \| DISEASES 653 \| BMP5 \| DISEASES 186 \| AGTR2 \| DISEASES 5476 \| CTSA \| DISEASES 1896 \| EDA \| DISEASES 4878 \| NPPA \| DISEASES 10159 \| ATP6AP2 \| DISEASES 1536 \| CYBB \| DISEASES 5251 \| PHEX \| DISEASES 1906 \| EDN1 \| DISEASES 9365 \| KL \| DISEASES 551 \| AVP \| DISEASES 7054 \| TH \| DISEASES 1667 \| DEFA1 \| DISEASES 728358 \| DEFA1B \| DISEASES 4336 \| MOBP \| DISEASES 50506 \| DUOX2 \| DISEASES 10203 \| CALCRL \| DISEASES 1621 \| DBH \| DISEASES 136319 \| MTPN \| DISEASES 11346 \| SYNPO \| DISEASES 6696 \| SPP1 \| DISEASES 23365 \| ARHGEF12 \| DISEASES 2868 \| GRK4 \| DISEASES 389362 \| PSMG4 \| DISEASES 200958 \| MUC20 \| DISEASES 387 \| RHOA \| DISEASES 83871 \| RAB34 \| DISEASES 10015 \| PDCD6IP \| DISEASES 197135 \| PATL2 \| DISEASES 6565 \| SLC15A2 \| DISEASES 7296 \| TXNRD1 \| DISEASES 567 \| B2M \| DISEASES 55554 \| KLK15 \| DISEASES
Locus	(Waiting for update.)

Disease ID	468
Disease	renal hypertension
Integrated Phenotype	(Waiting for update.)
Text Mined Phenotype	HPO \| Name \| Sentences' Count(Total Phenotypes:2) HP:0002634 \| Arteriosclerosis \| 1 HP:0000074 \| Ureteropelvic junction obstruction \| 1

Disease ID	468
Disease	renal hypertension
Manually Symptom	UMLS \| Name(Total Manually Symptoms:8) C2712322 \| tachycardia C1332965 \| congenital mesoblastic nephroma C0221755 \| abdominal bruit C0085413 \| adult polycystic kidney disease C0042341 \| varicocele C0038454 \| apoplexy C0027051 \| myocardial infarct C0022679 \| cystic kidney
Text Mined Symptom	(Waiting for update.)

Manually Genotype(Total Text Mining Genotypes:0)
(Waiting for update.)

All Snps(Total Genotypes:3)
snpId	pubmedId	geneId	geneSymbol	diseaseId	sourceId	sentence	score	Year	geneSymbol_dbSNP	CHROMOSOME	POS	REF	ALT
rs4961	12172317	1585	CYP11B2	umls:C0020544	BeFree	In a Caucasian population, the prevalence and incidence of hypertension, renal function and large artery stiffness were significantly correlated with polymorphisms in the genes encoding the angiotensin-converting enzyme (ACE I/D), aldosterone synthase (-C344T) and the cytoskeleton protein alpha-adducin (Gly460Trp).	0.002638474	2002	ADD1	4	2904980	G	T
rs4961	12172317	118	ADD1	umls:C0020544	BeFree	In a Caucasian population, the prevalence and incidence of hypertension, renal function and large artery stiffness were significantly correlated with polymorphisms in the genes encoding the angiotensin-converting enzyme (ACE I/D), aldosterone synthase (-C344T) and the cytoskeleton protein alpha-adducin (Gly460Trp).	0.000271442	2002	ADD1	4	2904980	G	T
rs4961	12172317	1636	ACE	umls:C0020544	BeFree	In a Caucasian population, the prevalence and incidence of hypertension, renal function and large artery stiffness were significantly correlated with polymorphisms in the genes encoding the angiotensin-converting enzyme (ACE I/D), aldosterone synthase (-C344T) and the cytoskeleton protein alpha-adducin (Gly460Trp).	0.00973957	2002	ADD1	4	2904980	G	T

GWASdb Annotation(Total Genotypes:0)
(Waiting for update.)

GWASdb Snp Trait(Total Genotypes:0)
(Waiting for update.)

Mapped by lexical matching(Total Items:0)
(Waiting for update.)

Mapped by homologous gene(Total Items:0)
(Waiting for update.)

Chemical(Total Drugs:15)
CUI	ChemicalName	ChemicalID	CasRN	DiseaseName	DiseaseID	DirectEvidence	PubMedIDs
C0020544	amlodipine	D017311	88150-42-9	hypertension, renal	MESH:D006977	therapeutic	21784887
C0020544	benazepril	C044946	86541-75-5	hypertension, renal	MESH:D006977	therapeutic	8763405
C0020544	bendroflumethiazide	D001539	73-48-3	hypertension, renal	MESH:D006977	therapeutic	3143437
C0020544	caffeine	D002110	1958/8/2	hypertension, renal	MESH:D006977	marker/mechanism	3044993
C0020544	cyclosporine	D016572	59865-13-3	hypertension, renal	MESH:D006977	marker/mechanism	3519476
C0020544	diltiazem	D004110	42399-41-7	hypertension, renal	MESH:D006977	therapeutic	1971779
C0020544	enalapril	D004656	75847-73-3	hypertension, renal	MESH:D006977	therapeutic	1951474
C0020544	indomethacin	D007213	53-86-1	hypertension, renal	MESH:D006977	marker/mechanism	4375905
C0020544	labetalol	D007741	36894-69-6	hypertension, renal	MESH:D006977	therapeutic	2567112
C0020544	minoxidil	D008914	38304-91-5	hypertension, renal	MESH:D006977	therapeutic	790007
C0020544	olmesartan	C437965	-	hypertension, renal	MESH:D006977	therapeutic	17587751
C0020544	phenylephrine	D010656	59-42-7	hypertension, renal	MESH:D006977	marker/mechanism	10406839
C0020544	prazosin	D011224	19216-56-9	hypertension, renal	MESH:D006977	therapeutic	802633
C0020544	ramipril	D017257	87333-19-5	hypertension, renal	MESH:D006977	therapeutic	17139187
C0020544	valsartan	D000068756	-	hypertension, renal	MESH:D006977	therapeutic	8763405

FDA approved drug and dosage information(Total Drugs:0)
(Waiting for update.)

FDA labeling changes(Total Drugs:0)
(Waiting for update.)

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