PedAM

Pediatric Disease Annotations & Medicines


	quadriplegia

Disease ID	1305
Disease	quadriplegia
Definition	Severe or complete loss of motor function in all four limbs which may result from BRAIN DISEASES; SPINAL CORD DISEASES; PERIPHERAL NERVOUS SYSTEM DISEASES; NEUROMUSCULAR DISEASES; or rarely MUSCULAR DISEASES. The locked-in syndrome is characterized by quadriplegia in combination with cranial muscle paralysis. Consciousness is spared and the only retained voluntary motor activity may be limited eye movements. This condition is usually caused by a lesion in the upper BRAIN STEM which injures the descending cortico-spinal and cortico-bulbar tracts.
Synonym	bilateral diplegia paralysis of all four limbs quadraplegia quadriplegia (disorder) quadriplegia [disease/finding] quadriplegia, unspecifd quadriplegia, unspecified quadriplegias tetraplegia tetraplegias
DOID	DOID:12835
ICD10	ICD10CM:G82.50
UMLS	C0034372
MeSH	D011782
SNOMED-CT	SNOMEDCT_US_2016_09_01:11538006
Comorbidity	UMLS \| Disease \| Sentences' Count(Total Sentences:21) C0026884 \| mutism \| 1 C0037928 \| myelopathies \| 1 C0035229 \| respiratory insufficiency \| 1 C0037928 \| myelopathy \| 1 C0039144 \| syringomyelia \| 1 C0021390 \| inflammatory bowel disease \| 1 C0020757 \| ichthyosis \| 1 C0009806 \| constipated \| 1 C0033975 \| psychosis \| 1 C0021831 \| bowel disease \| 1 C0025295 \| pneumococcal meningitis \| 1 C0003873 \| rheumatoid arthritis \| 1 C0025289 \| meningitis \| 1 C0026846 \| muscle atrophy \| 1 C0027873 \| neuromyelitis optica \| 1 C0023882 \| spastic diplegia \| 1 C0007789 \| cerebral palsy \| 1 C0036439 \| scoliosis \| 1 C1145670 \| respiratory failure \| 1 C0679466 \| cognitive deficits \| 1 C0004134 \| ataxia \| 1
Curated Gene	Entrez_id \| Symbol \| Resource(Total Genes:1) PMP22 \| 5376 \| CTD_human
Inferring Gene	(Waiting for update.)
Text Mined Gene	Entrez_id \| Symbol \| Score \| Resource(Total Genes:144) 64132 \| XYLT2 \| DISEASES 5010 \| CLDN11 \| DISEASES 55359 \| STYK1 \| DISEASES 440 \| ASNS \| DISEASES 9552 \| SPAG7 \| DISEASES 11154 \| AP4S1 \| DISEASES 2158 \| F9 \| DISEASES 79152 \| FA2H \| DISEASES 9896 \| FIG4 \| DISEASES 3764 \| KCNJ8 \| DISEASES 3759 \| KCNJ2 \| DISEASES 6626 \| SNRPA \| DISEASES 3630 \| INS \| DISEASES 9945 \| GFPT2 \| DISEASES 50617 \| ATP6V0A4 \| DISEASES 22856 \| CHSY1 \| DISEASES 1401 \| CRP \| DISEASES 1022 \| CDK7 \| DISEASES 10717 \| AP4B1 \| DISEASES 3569 \| IL6 \| DISEASES 84681 \| HINT2 \| DISEASES 6496 \| SIX3 \| DISEASES 2581 \| GALC \| DISEASES 4001 \| LMNB1 \| DISEASES 23431 \| AP4E1 \| DISEASES 80208 \| SPG11 \| DISEASES 9480 \| ONECUT2 \| DISEASES 29855 \| UBN1 \| DISEASES 443 \| ASPA \| DISEASES 3977 \| LIFR \| DISEASES 4072 \| EPCAM \| DISEASES 57679 \| ALS2 \| DISEASES 80321 \| CEP70 \| DISEASES 54504 \| CPVL \| DISEASES 5286 \| PIK3C2A \| DISEASES 7008 \| TEF \| DISEASES 51411 \| BIN2 \| DISEASES 2588 \| GALNS \| DISEASES 9775 \| EIF4A3 \| DISEASES 5972 \| REN \| DISEASES 285362 \| SUMF1 \| DISEASES 3145 \| HMBS \| DISEASES 23704 \| KCNE4 \| DISEASES 2895 \| GRID2 \| DISEASES 5741 \| PTH \| DISEASES 5903 \| RANBP2 \| DISEASES 7345 \| UCHL1 \| DISEASES 9510 \| ADAMTS1 \| DISEASES 760 \| CA2 \| DISEASES 1836 \| SLC26A2 \| DISEASES 9992 \| KCNE2 \| DISEASES 1636 \| ACE \| DISEASES 8209 \| C21orf33 \| DISEASES 162417 \| NAGS \| DISEASES 213 \| ALB \| DISEASES 84315 \| MON1A \| DISEASES 29123 \| ANKRD11 \| DISEASES 7846 \| TUBA1A \| DISEASES 55957 \| LIN37 \| DISEASES 148170 \| CDC42EP5 \| DISEASES 80150 \| ASRGL1 \| DISEASES 79058 \| ASPSCR1 \| DISEASES 478 \| ATP1A3 \| DISEASES 166614 \| DCLK2 \| DISEASES 5354 \| PLP1 \| DISEASES 6504 \| SLAMF1 \| DISEASES 57521 \| RPTOR \| DISEASES 23592 \| LEMD3 \| DISEASES 2147 \| F2 \| DISEASES 5340 \| PLG \| DISEASES 285590 \| SH3PXD2B \| DISEASES 10008 \| KCNE3 \| DISEASES 6578 \| SLCO2A1 \| DISEASES 7915 \| ALDH5A1 \| DISEASES 274 \| BIN1 \| DISEASES 147912 \| SIX5 \| DISEASES 124590 \| USH1G \| DISEASES 1351 \| COX8A \| DISEASES 25915 \| NDUFAF3 \| DISEASES 113457 \| TUBA3D \| DISEASES 246329 \| STAC3 \| DISEASES 277 \| AMY1B \| DISEASES 796 \| CALCA \| DISEASES 25987 \| TSKU \| DISEASES 8398 \| PLA2G6 \| DISEASES 2290 \| FOXG1 \| DISEASES 5348 \| FXYD1 \| DISEASES 64087 \| MCCC2 \| DISEASES 92399 \| MRRF \| DISEASES 3767 \| KCNJ11 \| DISEASES 224 \| ALDH3A2 \| DISEASES 112476 \| PRRT2 \| DISEASES 9464 \| HAND2 \| DISEASES 9179 \| AP4M1 \| DISEASES 4151 \| MB \| DISEASES 5792 \| PTPRF \| DISEASES 5455 \| POU3F3 \| DISEASES 56259 \| CTNNBL1 \| DISEASES 55157 \| DARS2 \| DISEASES 779 \| CACNA1S \| DISEASES 57165 \| GJC2 \| DISEASES 3142 \| HLX \| DISEASES 2153 \| F5 \| DISEASES 632 \| BGLAP \| DISEASES 4000 \| LMNA \| DISEASES 5710 \| PSMD4 \| DISEASES 134728 \| IRAK1BP1 \| DISEASES 278 \| AMY1C \| DISEASES 276 \| AMY1A \| DISEASES 23443 \| SLC35A3 \| DISEASES 959 \| CD40LG \| DISEASES 1491 \| CTH \| DISEASES 10564 \| ARFGEF2 \| DISEASES 27286 \| SRPX2 \| DISEASES 1282 \| COL4A1 \| DISEASES 4340 \| MOG \| DISEASES 127262 \| TPRG1L \| DISEASES 551 \| AVP \| DISEASES 415 \| ARSE \| DISEASES 51091 \| SEPSECS \| DISEASES 1761 \| DMRT1 \| DISEASES 23189 \| KANK1 \| DISEASES 4155 \| MBP \| DISEASES 2235 \| FECH \| DISEASES 340152 \| ZC3H12D \| DISEASES 2524 \| FUT2 \| DISEASES 1621 \| DBH \| DISEASES 5660 \| PSAP \| DISEASES 5048 \| PAFAH1B1 \| DISEASES 57703 \| CWC22 \| DISEASES 6329 \| SCN4A \| DISEASES 3702 \| ITK \| DISEASES 10908 \| PNPLA6 \| DISEASES 81704 \| DOCK8 \| DISEASES 23089 \| PEG10 \| DISEASES 8530 \| CST7 \| DISEASES 6949 \| TCOF1 \| DISEASES 2994 \| GYPB \| DISEASES 4671 \| NAIP \| DISEASES 91056 \| AP5B1 \| DISEASES 4782 \| NFIC \| DISEASES 100124700 \| HOTAIR \| DISEASES 102723508 \| KANTR \| DISEASES 103752588 \| PACERR \| DISEASES
Locus	(Waiting for update.)

Disease ID	1305
Disease	quadriplegia
Integrated Phenotype	(Waiting for update.)
Text Mined Phenotype	HPO \| Name \| Sentences' Count(Total Phenotypes:35) HP:0001257 \| Spasticity \| 3 HP:0012399 \| Bedsore \| 1 HP:0007185 \| Loss of consciousness \| 1 HP:0011344 \| Severe global developmental delay \| 1 HP:0012531 \| Pain \| 1 HP:0002300 \| Muteness \| 1 HP:0100310 \| Extradural hematoma \| 1 HP:0000709 \| Psychosis \| 1 HP:0001263 \| Developmental retardation \| 1 HP:0001251 \| Ataxia \| 1 HP:0002607 \| Anal incontinence \| 1 HP:0008064 \| Ichthyosis \| 1 HP:0003396 \| Syringomyelia \| 1 HP:0012672 \| Akinetic mutism \| 1 HP:0002093 \| progressive respiratory failure \| 1 HP:0002459 \| Dysautonomia \| 1 HP:0001370 \| Rheumatoid arthritis \| 1 HP:0030833 \| Neck pain \| 1 HP:0003202 \| Neurogenic muscle atrophy, especially in the lower limbs \| 1 HP:0001349 \| Facial paresis, bilateral \| 1 HP:0001276 \| Hypertonia \| 1 HP:0001262 \| Somnolence \| 1 HP:0002061 \| Lower limb spasticity \| 1 HP:0001264 \| Spastic diplegia \| 1 HP:0100021 \| Cerebral palsy \| 1 HP:0003414 \| Atlantoaxial subluxation \| 1 HP:0030051 \| Walking on tiptoes \| 1 HP:0001249 \| Mental retardation \| 1 HP:0002878 \| Respiratory failure \| 1 HP:0002196 \| Myelopathy \| 1 HP:0001287 \| Meningitis \| 1 HP:0001695 \| Cardiac arrest \| 1 HP:0003228 \| High blood sodium levels \| 1 HP:0002650 \| Scoliosis \| 1 HP:0100543 \| Cognitive deficits \| 1

Disease ID	1305
Disease	quadriplegia
Manually Symptom	(Waiting for update.)
Text Mined Symptom	(Waiting for update.)

Manually Genotype(Total Text Mining Genotypes:0)
(Waiting for update.)

All Snps(Total Genotypes:0)
(Waiting for update.)

GWASdb Annotation(Total Genotypes:0)
(Waiting for update.)

GWASdb Snp Trait(Total Genotypes:0)
(Waiting for update.)

Mapped by lexical matching(Total Items:0)
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Mapped by homologous gene(Total Items:0)
(Waiting for update.)

Chemical(Total Drugs:12)
CUI	ChemicalName	ChemicalID	CasRN	DiseaseName	DiseaseID	DirectEvidence	PubMedIDs
C0034372	amphetamine	D000661	300-62-9	quadriplegia	MESH:D011782	marker/mechanism	16161930
C0034372	baclofen	D001418	1134-47-0	quadriplegia	MESH:D011782	therapeutic	10597813
C0034372	betamethasone	D001623	378-44-9	quadriplegia	MESH:D011782	marker/mechanism	2636374
C0034372	bisoprolol	D017298	66722-44-9	quadriplegia	MESH:D011782	marker/mechanism	15313766
C0034372	colchicine	D003078	64-86-8	quadriplegia	MESH:D011782	marker/mechanism	16148013
C0034372	dronabinol	D013759	-	quadriplegia	MESH:D011782	marker/mechanism	16161930
C0034372	diclofenac	D004008	15307-86-5	quadriplegia	MESH:D011782	marker/mechanism	11123398
C0034372	enflurane	D004737	13838-16-9	quadriplegia	MESH:D011782	marker/mechanism	2145134
C0034372	lidocaine	D008012	137-58-6	quadriplegia	MESH:D011782	marker/mechanism	16102894
C0034372	methotrexate	D008727	1959/5/2	quadriplegia	MESH:D011782	marker/mechanism	4819222
C0034372	spironolactone	D013148	1952/1/7	quadriplegia	MESH:D011782	marker/mechanism	2993981
C0034372	vincristine	D014750	-	quadriplegia	MESH:D011782	marker/mechanism	10390891

FDA approved drug and dosage information(Total Drugs:0)
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FDA labeling changes(Total Drugs:0)
(Waiting for update.)

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