PedAM

Pediatric Disease Annotations & Medicines


	pyoderma gangrenosum

Disease ID	137
Disease	pyoderma gangrenosum
Definition	An idiopathic, rapidly evolving, and severely debilitating disease occurring most commonly in association with chronic ulcerative colitis. It is characterized by the presence of boggy, purplish ulcers with undermined borders, appearing mostly on the legs. The majority of cases are in people between 40 and 60 years old. Its etiology is unknown.
Synonym	gangrenosum pyoderma gangrenous pyoderma pyoderma gangenosum pyoderma gangrenosa pyoderma gangrenosum (disorder) pyoderma gangrenosum [disease/finding] pyoderma gangrenous
Orphanet	ORPHANET:48104
DOID	DOID:8553
ICD10	ICD10CM:L88
UMLS	C0085652
MeSH	D017511
SNOMED-CT	SNOMEDCT_US_2016_09_01:74578003
Comorbidity	UMLS \| Disease \| Sentences' Count(Total Sentences:60) C0009324 \| ulcerative colitis \| 13 C0021390 \| inflammatory bowel disease \| 12 C0021831 \| bowel disease \| 11 C0009319 \| colitis \| 8 C0010346 \| crohn's disease \| 5 C0003873 \| rheumatoid arthritis \| 3 C0036416 \| scleritis \| 2 C0042384 \| vasculitis \| 2 C0007102 \| colon cancer \| 2 C0162836 \| hidradenitis suppurativa \| 2 C0085160 \| hidradenitis \| 2 C0009447 \| common variable immunodeficiency \| 2 C0026986 \| myelodysplastic syndrome \| 2 C0001815 \| myelofibrosis \| 1 C0241910 \| autoimmune hepatitis \| 1 C0030807 \| pemphigus \| 1 C0034902 \| pure red cell aplasia \| 1 C0007134 \| renal cell carcinoma \| 1 C0029443 \| osteomyelitis \| 1 C0042769 \| virus infection \| 1 C0004903 \| beckwith wiedemann syndrome \| 1 C0007570 \| celiac disease \| 1 C0079774 \| peripheral t-cell lymphoma \| 1 C0281963 \| red cell aplasia \| 1 C0001815 \| chronic idiopathic myelofibrosis \| 1 C0019158 \| hepatitis \| 1 C0221023 \| cyclic neutropenia \| 1 C1692886 \| pyogenic arthritis \| 1 C0034150 \| purpura \| 1 C0263398 \| erythema elevatum diutinum \| 1 C0007134 \| renal carcinoma \| 1 C0019196 \| hepatitis c \| 1 C0035222 \| acute respiratory distress syndrome \| 1 C0276758 \| fusarium infection \| 1 C0221026 \| x-linked agammaglobulinemia \| 1 C0021171 \| incontinentia pigmenti \| 1 C1704437 \| respiratory distress syndrome \| 1 C0011603 \| dermatitis \| 1 C0013595 \| eczema \| 1 C0272412 \| splenic abscess \| 1 C0003864 \| arthritis \| 1 C0036421 \| systemic sclerosis \| 1 C0024314 \| lymphoproliferative disorder \| 1 C0004943 \| behcet's disease \| 1 C0030312 \| pancytopenia \| 1 C0002726 \| amyloidosis \| 1 C0001815 \| idiopathic myelofibrosis \| 1 C0030809 \| pemphigus vulgaris \| 1 C0012813 \| diverticulitis \| 1 C0001768 \| agammaglobulinemia \| 1 C0022568 \| keratitis \| 1 C0043117 \| idiopathic thrombocytopenic purpura \| 1 C0400821 \| microscopic colitis \| 1 C0012814 \| colonic diverticulitis \| 1 C0026764 \| myeloma \| 1 C0152026 \| retinal vasculitis \| 1 C0039263 \| takayasu's arteritis \| 1 C0376545 \| hematological malignancy \| 1 C0206141 \| idiopathic hypereosinophilic syndrome \| 1 C0027947 \| neutropenia \| 1
Curated Gene	(Waiting for update.)
Inferring Gene	(Waiting for update.)
Text Mined Gene	Entrez_id \| Symbol \| Score \| Resource(Total Genes:82) 7132 \| TNFRSF1A \| DISEASES 26469 \| PTPN18 \| DISEASES 4210 \| MEFV \| DISEASES 973 \| CD79A \| DISEASES 55851 \| PSENEN \| DISEASES 4353 \| MPO \| DISEASES 1440 \| CSF3 \| DISEASES 4598 \| MVK \| DISEASES 566 \| AZU1 \| DISEASES 5657 \| PRTN3 \| DISEASES 2703 \| GJA8 \| DISEASES 5782 \| PTPN12 \| DISEASES 4695 \| NDUFA2 \| DISEASES 1401 \| CRP \| DISEASES 9958 \| USP15 \| DISEASES 3569 \| IL6 \| DISEASES 3557 \| IL1RN \| DISEASES 27179 \| IL36A \| DISEASES 26525 \| IL36RN \| DISEASES 9663 \| LPIN2 \| DISEASES 23184 \| MESDC2 \| DISEASES 7011 \| TEP1 \| DISEASES 23523 \| CABIN1 \| DISEASES 8424 \| BBOX1 \| DISEASES 3553 \| IL1B \| DISEASES 9410 \| SNRNP40 \| DISEASES 943 \| TNFRSF8 \| DISEASES 59274 \| MESDC1 \| DISEASES 4319 \| MMP10 \| DISEASES 3606 \| IL18 \| DISEASES 6352 \| CCL5 \| DISEASES 58191 \| CXCL16 \| DISEASES 23385 \| NCSTN \| DISEASES 7203 \| CCT3 \| DISEASES 3562 \| IL3 \| DISEASES 1437 \| CSF2 \| DISEASES 79841 \| AGBL2 \| DISEASES 5896 \| RAG1 \| DISEASES 64127 \| NOD2 \| DISEASES 56547 \| MMP26 \| DISEASES 3868 \| KRT16 \| DISEASES 3689 \| ITGB2 \| DISEASES 9655 \| SOCS5 \| DISEASES 56246 \| MRAP \| DISEASES 57381 \| RHOJ \| DISEASES 56776 \| FMN2 \| DISEASES 91662 \| NLRP12 \| DISEASES 9322 \| TRIP10 \| DISEASES 10938 \| EHD1 \| DISEASES 23765 \| IL17RA \| DISEASES 5155 \| PDGFB \| DISEASES 2242 \| FES \| DISEASES 114548 \| NLRP3 \| DISEASES 5275 \| SERPINB13 \| DISEASES 3605 \| IL17A \| DISEASES 79092 \| CARD14 \| DISEASES 3683 \| ITGAL \| DISEASES 9332 \| CD163 \| DISEASES 58484 \| NLRC4 \| DISEASES 9447 \| AIM2 \| DISEASES 10758 \| TRAF3IP2 \| DISEASES 8804 \| CREG1 \| DISEASES 959 \| CD40LG \| DISEASES 5236 \| PGM1 \| DISEASES 6491 \| STIL \| DISEASES 958 \| CD40 \| DISEASES 2833 \| CXCR3 \| DISEASES 5696 \| PSMB8 \| DISEASES 7133 \| TNFRSF1B \| DISEASES 4524 \| MTHFR \| DISEASES 54790 \| TET2 \| DISEASES 22900 \| CARD8 \| DISEASES 347734 \| SLC35B2 \| DISEASES 50489 \| CD207 \| DISEASES 9050 \| PSTPIP2 \| DISEASES 5777 \| PTPN6 \| DISEASES 7124 \| TNF \| DISEASES 6358 \| CCL14 \| DISEASES 834 \| CASP1 \| DISEASES 2263 \| FGFR2 \| DISEASES 9051 \| PSTPIP1 \| DISEASES 22861 \| NLRP1 \| DISEASES
Locus	(Waiting for update.)

Disease ID	137
Disease	pyoderma gangrenosum
Integrated Phenotype	HPO \| Name(Total Integrated Phenotypes:15) HP:0001945 \| Fever HP:0002037 \| Inflammation of the large intestine HP:0002829 \| Arthralgia HP:0200039 \| Pustule HP:0001075 \| Atrophic scars HP:0200037 \| Skin vesicle HP:0001370 \| Rheumatoid arthritis HP:0010702 \| Increased antibody level in blood HP:0200034 \| Papule HP:0002863 \| Myelodysplasia HP:0100614 \| Myositis HP:0200042 \| Skin ulcer HP:0008066 \| Abnormal blistering of the skin HP:0012324 \| Myeloid leukemia HP:0003326 \| Myalgia
Text Mined Phenotype	HPO \| Name \| Sentences' Count(Total Phenotypes:37) HP:0100279 \| Ulcerative colitis \| 12 HP:0002583 \| Colitis \| 7 HP:0100280 \| Morbus Crohn \| 5 HP:0001370 \| Rheumatoid arthritis \| 3 HP:0003003 \| Colon cancer \| 2 HP:0100532 \| Scleritis \| 2 HP:0002863 \| Myelodysplastic syndrome \| 2 HP:0002633 \| Vasculitis \| 2 HP:0040154 \| Hidradenitis suppurativa \| 2 HP:0005584 \| Renal cell carcinoma \| 2 HP:0001762 \| Talipes equinovarus \| 1 HP:0000979 \| Purpura \| 1 HP:0100550 \| Rupture of tendons \| 1 HP:0005523 \| Lymphoproliferative disorder \| 1 HP:0002955 \| Granulomatosis \| 1 HP:0001876 \| Low blood cell count \| 1 HP:0012410 \| Pure red cell aplasia \| 1 HP:0100583 \| Corneal perforation \| 1 HP:0200042 \| Skin ulcer \| 1 HP:0100847 \| Pustulosis palmaris et plantaris \| 1 HP:0011974 \| Myelofibrosis \| 1 HP:0012115 \| Liver inflammation \| 1 HP:0001875 \| Neutropenia \| 1 HP:0002608 \| Celiac disease \| 1 HP:0004432 \| Agammaglobulinaemia \| 1 HP:0008110 \| Equinovarus deformity \| 1 HP:0000491 \| Corneal inflammation \| 1 HP:0100570 \| Carcinoid tumor \| 1 HP:0011034 \| Amyloid disease \| 1 HP:0002754 \| Bone infection \| 1 HP:0000964 \| Eczema \| 1 HP:0001369 \| Arthritis \| 1 HP:0002098 \| Respiratory distress \| 1 HP:0030731 \| Carcinoma \| 1 HP:0000155 \| Oral ulcer \| 1 HP:0002721 \| Immunodeficiency \| 1 HP:0012089 \| Arteritis \| 1

Disease ID	137
Disease	pyoderma gangrenosum
Manually Symptom	UMLS \| Name(Total Manually Symptoms:27) C2073625 \| pleural effusion C1562901 \| peripheral ulcerative keratitis C1555769 \| pulmonary disease C1304219 \| rheumatoid neutrophilic dermatitis C1257847 \| hemorrhagic rectocolitis C1136085 \| monoclonal gammopathy C0748159 \| pulmonary involvement C0586407 \| skin symptoms C0566602 \| primary sclerosing cholangitis C0497156 \| lymphadenopathy C0339194 \| nodular scleritis C0272396 \| lymph node abscess C0206061 \| interstitial pneumonia C0178703 \| hypertrophic osteoarthropathy C0155354 \| scleromalacia perforans C0086438 \| hypogammaglobulinemia C0039263 \| takayasu's arteritis C0037928 \| myelopathy C0037284 \| skin lesions C0032305 \| pneumocystis carinii pneumonia C0032285 \| pneumonitis C0024205 \| adenitis C0023223 \| leg ulcers C0022408 \| articular disease C0010346 \| crohn's disease C0009324 \| ulcerative colitis C0003864 \| arthritis
Text Mined Symptom	UMLS \| Name \| Sentences' Count(Total Symptoms:10) C0009324 \| ulcerative colitis \| 12 C0010346 \| crohn's disease \| 5 C0748159 \| pulmonary involvement \| 4 C0023223 \| leg ulcers \| 2 C1304219 \| rheumatoid neutrophilic dermatitis \| 1 C1562901 \| peripheral ulcerative keratitis \| 1 C0039263 \| takayasu's arteritis \| 1 C0037284 \| skin lesions \| 1 C0339194 \| nodular scleritis \| 1 C0003864 \| arthritis \| 1

Manually Genotype(Total Text Mining Genotypes:0)
(Waiting for update.)

All Snps(Total Genotypes:0)
(Waiting for update.)

GWASdb Annotation(Total Genotypes:0)
(Waiting for update.)

GWASdb Snp Trait(Total Genotypes:0)
(Waiting for update.)

Mapped by lexical matching(Total Items:1)
HP ID	HP Name	MP ID	MP Name	Annotation
HP:0004313	Decreased antibody level in blood	MP:0001417	decreased exploration in new environment;

Mapped by homologous gene(Total Items:1)
HP ID	HP Name	MP ID	MP Name	Annotation
HP:0002716	Lymphadenopathy	MP:0002420	abnormal adaptive immunity;HP:0002196	Myelopathy

Chemical(Total Drugs:3)
CUI	ChemicalName	ChemicalID	CasRN	DiseaseName	DiseaseID	DirectEvidence	PubMedIDs
C0085652	clofazimine	D002991	2030-63-9	pyoderma gangrenosum	MESH:D017511	therapeutic	7387877
C0085652	tacrolimus	D016559	109581-93-3	pyoderma gangrenosum	MESH:D017511	therapeutic	17076739
C0085652	thalidomide	D013792	50-35-1	pyoderma gangrenosum	MESH:D017511	therapeutic	12499476

FDA approved drug and dosage information(Total Drugs:0)
(Waiting for update.)

FDA labeling changes(Total Drugs:0)
(Waiting for update.)

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