PedAM

Pediatric Disease Annotations & Medicines


	pulmonary hypertension

Disease ID	660
Disease	pulmonary hypertension
Definition	Increased VASCULAR RESISTANCE in the PULMONARY CIRCULATION, usually secondary to HEART DISEASES or LUNG DISEASES.
Synonym	hypertension caused by lung disease hypertension pulm hypertension pulmonary hypertension, pulmonary hypertension, pulmonary [disease/finding] pht - pulmonary hypertension pulm hypertension pulmonary artery hypertension pulmonary hypertension (disorder) pulmonary hypertension disorder pulmonary hypertension nos pulmonary hypertension, nos
DOID	DOID:6432
UMLS	C0020542
MeSH	D006976
SNOMED-CT	SNOMEDCT_US_2016_09_01:70995007
Comorbidity	UMLS \| Disease \| Sentences' Count(Total Sentences:259) C0018801 \| heart failure \| 80 C0018799 \| heart disease \| 69 C0024115 \| lung disease \| 40 C0152021 \| congenital heart disease \| 39 C0024117 \| chronic obstructive pulmonary disease \| 33 C0024115 \| pulmonary disease \| 29 C0036421 \| systemic sclerosis \| 29 C0600260 \| obstructive pulmonary disease \| 24 C0034069 \| pulmonary fibrosis \| 23 C0002895 \| sickle cell disease \| 22 C0206062 \| interstitial lung disease \| 20 C1800706 \| idiopathic pulmonary fibrosis \| 19 C1145670 \| respiratory failure \| 17 C0153500 \| heart ca \| 16 C0040961 \| tricuspid regurgitation \| 16 C0024115 \| lung diseases \| 14 C0020538 \| hypertension \| 12 C0024141 \| systemic lupus erythematosus \| 12 C0024117 \| chronic obstructive pulmonary disease (copd) \| 12 C0878544 \| cardiomyopathy \| 11 C0019284 \| diaphragmatic hernia \| 11 C0009782 \| connective tissue disease \| 10 C0011644 \| scleroderma \| 10 C0013990 \| emphysema \| 9 C0006287 \| bronchopulmonary dysplasia \| 9 C0039730 \| thalassemia \| 8 C0034072 \| cor pulmonale \| 8 C0023895 \| liver disease \| 8 C0034065 \| pulmonary embolism \| 7 C0600260 \| obstructive lung disease \| 6 C1619734 \| pulmonary arterial hypertension \| 6 C0042373 \| vascular disease \| 5 C0409974 \| lupus erythematosus \| 5 C0002878 \| hemolytic anemia \| 5 C0024117 \| chronic obstructive lung disease \| 5 C0003507 \| aortic stenosis \| 5 C0023890 \| cirrhosis \| 5 C0035229 \| respiratory insufficiency \| 5 C0026269 \| mitral stenosis \| 5 C0002871 \| anemia \| 4 C0018799 \| cardiac disease \| 4 C0032285 \| pneumonia \| 4 C0037315 \| sleep apnea \| 4 C0026265 \| mitral valve disease \| 4 C0018818 \| ventricular septal defect \| 4 C0010674 \| cystic fibrosis \| 4 C0035435 \| rheumatic disease \| 4 C0036202 \| sarcoidosis \| 4 C0024115 \| pulmonary diseases \| 4 C0085786 \| idiopathic interstitial pneumonia \| 4 C0034091 \| pulmonary veno-occlusive disease \| 4 C0026266 \| mitral regurgitation \| 4 C0040961 \| tricuspid insufficiency \| 4 C0035204 \| respiratory disease \| 4 C0022661 \| chronic kidney disease \| 4 C0009782 \| connective tissue diseases \| 4 C0040188 \| tic disorders \| 3 C0018801 \| cardiac failure \| 3 C0039445 \| hereditary haemorrhagic telangiectasia \| 3 C0027022 \| myeloproliferative disorder \| 3 C0025048 \| meconium aspiration \| 3 C0020550 \| hyperthyroidism \| 3 C0018816 \| septal defects \| 3 C1704437 \| respiratory distress syndrome \| 3 C0007196 \| restrictive cardiomyopathy \| 3 C0027022 \| myeloproliferative disorders \| 3 C0022661 \| end-stage renal disease \| 3 C0035435 \| rheumatic diseases \| 3 C0034069 \| lung fibrosis \| 3 C0040053 \| thrombus \| 3 C0948265 \| metabolic syndrome \| 3 C0020538 \| systemic hypertension \| 3 C0018799 \| cardiac diseases \| 3 C0006271 \| bronchiolitis \| 3 C0022658 \| kidney disease \| 3 C0035222 \| acute respiratory distress syndrome \| 3 C0039445 \| hereditary hemorrhagic telangiectasia \| 3 C1135196 \| diastolic heart failure \| 2 C0031039 \| pericardial effusion \| 2 C0006017 \| pertussis \| 2 C0023788 \| whipple's disease \| 2 C0020502 \| hyperparathyroidism \| 2 C0010068 \| coronary artery disease \| 2 C0002895 \| sickle cell anaemia \| 2 C1292778 \| chronic myeloproliferative disorder \| 2 C0006272 \| bronchiolitis obliterans \| 2 C0035921 \| congenital rubella \| 2 C0007194 \| obstructive cardiomyopathy \| 2 C0025048 \| meconium aspiration syndrome \| 2 C0020541 \| portal hypertension \| 2 C0007193 \| dilated cardiomyopathy \| 2 C0025064 \| mediastinitis \| 2 C1292778 \| chronic myeloproliferative disorders \| 2 C0040053 \| thrombosis \| 2 C0034072 \| cardiopulmonary disease \| 2 C0751651 \| mitochondrial disorder \| 2 C0033687 \| proteinuria \| 2 C0042384 \| vasculitis \| 2 C0018802 \| congestive heart failure \| 2 C0036323 \| schistosomiasis \| 2 C0011570 \| depression \| 2 C0398623 \| thrombophilia \| 2 C0022658 \| renal disease \| 2 C0085404 \| poems syndrome \| 2 C0035921 \| congenital rubella syndrome \| 2 C0042769 \| virus infection \| 2 C0019618 \| histiocytosis \| 2 C0003467 \| anxiety \| 2 C0020503 \| secondary hyperparathyroidism \| 2 C0039446 \| telangiectasia \| 2 C1527336 \| sjogren's syndrome \| 2 C0028754 \| obesity \| 2 C0553980 \| endomyocardial fibrosis \| 2 C0520679 \| obstructive sleep apnea \| 2 C0036205 \| pulmonary sarcoidosis \| 2 C0018799 \| heart diseases \| 2 C0018213 \| graves' disease \| 2 C0003507 \| aortic valve stenosis \| 2 C0007194 \| hypertrophic obstructive cardiomyopathy \| 2 C0011847 \| diabetes \| 2 C1135191 \| systolic heart failure \| 2 C0206062 \| interstitial lung diseases \| 2 C0037315 \| sleep apnoea \| 2 C0751651 \| mitochondrial disorders \| 2 C0035439 \| rheumatic heart disease \| 2 C0520679 \| obstructive sleep apnoea \| 2 C0003615 \| appendicitis \| 1 C0018802 \| congestive cardiac failure \| 1 C1700942 \| idiopathic pulmonary arterial hypertension \| 1 C0022661 \| end-stage kidney disease \| 1 C0035204 \| respiratory diseases \| 1 C0022739 \| klippel-trenaunay-weber syndrome \| 1 C0026691 \| kawasaki disease \| 1 C0005283 \| beta thalassaemia \| 1 C0836924 \| thrombocytosis \| 1 C0042373 \| vascular disorders \| 1 C0011127 \| decubitus \| 1 C0264716 \| chronic heart failure \| 1 C0600452 \| hepatopulmonary syndrome \| 1 C0152095 \| trisomy 13 \| 1 C0085655 \| polymyositis \| 1 C0008312 \| primary biliary cirrhosis \| 1 C0031069 \| familial mediterranean fever \| 1 C0026654 \| moyamoya disease \| 1 C0262428 \| collagen vascular disease \| 1 C0022116 \| ischaemia \| 1 C0085278 \| antiphospholipid syndrome \| 1 C0039263 \| takayasu's arteritis \| 1 C0085113 \| neurofibromatosis \| 1 C0034065 \| pulmonary embolus \| 1 C0016522 \| patent foramen ovale \| 1 C0041327 \| pulmonary tuberculosis \| 1 C0024291 \| hemophagocytic lymphohistiocytosis \| 1 C1510471 \| vitamin deficiencies \| 1 C1258104 \| diffuse systemic sclerosis \| 1 C0022658 \| nephropathy \| 1 C0027022 \| chronic myeloproliferative disease \| 1 C0003504 \| aortic insufficiency \| 1 C0151744 \| myocardial ischaemia \| 1 C0018818 \| ventricular septal defects \| 1 C0010054 \| coronary atherosclerosis \| 1 C0085404 \| crow-fukase syndrome \| 1 C0007194 \| hypertrophic cardiomyopathy \| 1 C0242379 \| lung cancer \| 1 C0041321 \| miliary tuberculosis \| 1 C0023788 \| whipple disease \| 1 C0042373 \| vascular disorder \| 1 C0085096 \| peripheral vascular disease \| 1 C0005283 \| beta thalassemia \| 1 C0008312 \| biliary cirrhosis \| 1 C0019196 \| hepatitis c \| 1 C0003873 \| rheumatoid arthritis \| 1 C0149925 \| small cell lung cancer \| 1 C0018995 \| hemochromatosis \| 1 C0021053 \| immune dysfunction \| 1 C0018824 \| valvular heart disease \| 1 C0027947 \| neutropenia \| 1 C0155765 \| microangiopathy \| 1 C0005411 \| biliary atresia \| 1 C0022661 \| end stage renal disease \| 1 C0017205 \| gaucher disease \| 1 C0852283 \| neonatal respiratory distress \| 1 C0151744 \| myocardial ischemia \| 1 C0238377 \| talcosis \| 1 C1261473 \| sarcomas \| 1 C0009326 \| collagen disease \| 1 C0155672 \| acute cor pulmonale \| 1 C0034063 \| pulmonary oedema \| 1 C0032285 \| lung inflammation \| 1 C0006277 \| bronchitis \| 1 C0018213 \| graves disease \| 1 C0036421 \| systemic scleroderma \| 1 C0002895 \| sickle-cell anaemia \| 1 C0005411 \| congenital biliary atresia \| 1 C0023890 \| liver cirrhosis \| 1 C0016052 \| fibromuscular dysplasia \| 1 C0019158 \| hepatitis \| 1 C0024115 \| pulmonary disorders \| 1 C0032273 \| pneumoconiosis \| 1 C0019045 \| hemoglobinopathies \| 1 C0003850 \| arteriosclerosis \| 1 C0034734 \| raynaud's syndrome \| 1 C0264766 \| rheumatic mitral stenosis \| 1 C1960469 \| left ventricular noncompaction \| 1 C0001418 \| adenocarcinoma \| 1 C0016522 \| secundum atrial septal defect \| 1 C0003857 \| arteriovenous malformation \| 1 C0023895 \| liver diseases \| 1 C0026266 \| mitral insufficiency \| 1 C0013080 \| trisomy 21 \| 1 C0002871 \| anaemia \| 1 C0085786 \| fibrosing alveolitis \| 1 C0002312 \| hemoglobin h disease \| 1 C0034067 \| pulmonary emphysema \| 1 C1290344 \| nonspecific interstitial pneumonia \| 1 C0007131 \| non-small cell lung cancer \| 1 C0003969 \| vitamin c deficiency \| 1 C0032285 \| pneumonitis \| 1 C0026654 \| moyamoya \| 1 C0003469 \| anxiety disorder \| 1 C0018213 \| grave's disease \| 1 C0206138 \| crest syndrome \| 1 C0027022 \| myeloproliferative disease \| 1 C0018799 \| cardiac disorders \| 1 C0036474 \| scurvy \| 1 C0206633 \| angiomyolipoma \| 1 C0027022 \| myeloproliferative neoplasms \| 1 C0017919 \| glycogen storage disease \| 1 C0162429 \| malnutrition \| 1 C0001815 \| myelofibrosis \| 1 C0032357 \| poland syndrome \| 1 C0497327 \| dementia \| 1 C0007222 \| cardiovascular disorders \| 1 C0004943 \| behcet's disease \| 1 C0033860 \| psoriasis \| 1 C0004096 \| asthma \| 1 C1956257 \| pulmonary stenosis \| 1 C0017205 \| gaucher's disease \| 1 C0037315 \| sleep disordered breathing \| 1 C0037889 \| hereditary spherocytosis \| 1 C0034063 \| pulmonary edema \| 1 C0600260 \| obstructive pulmonary diseases \| 1 C0024790 \| paroxysmal nocturnal haemoglobinuria \| 1 C0600260 \| obstructive lung diseases \| 1 C0018824 \| heart valve disease \| 1 C0087086 \| thrombi \| 1 C0021053 \| immune disease \| 1 C0152021 \| congenital heart disorder \| 1 C0019621 \| histiocytosis x \| 1 C0003469 \| anxiety disorders \| 1 C0282193 \| iron overload \| 1 C0014118 \| endocarditis \| 1 C0031542 \| phlebitis \| 1 C0004153 \| atherosclerosis \| 1 C1531608 \| smoldering multiple myeloma \| 1 C0017919 \| glycogenosis \| 1 C0002878 \| hemolytic anemias \| 1 C0019621 \| langerhans cell histiocytosis \| 1 C0003165 \| coal worker's pneumoconiosis \| 1
Curated Gene	Entrez_id \| Symbol \| Resource(Total Genes:32) EIF2AK4 \| 440275 \| CTD_human;GHR TNF \| 7124 \| CTD_human SOD2 \| 6648 \| CTD_human NOS3 \| 4846 \| CTD_human SLC6A4 \| 6532 \| CTD_human CCL2 \| 6347 \| CTD_human EDN1 \| 1906 \| CTD_human FBLN5 \| 10516 \| CTD_human BRD4 \| 23476 \| CTD_human ATP7A \| 538 \| CTD_human ACE \| 1636 \| CTD_human GBA \| 2629 \| CTD_human NPPB \| 4879 \| CTD_human SLC31A1 \| 1317 \| CTD_human PRKG1 \| 5592 \| CTD_human ALOX5 \| 240 \| CTD_human LOX \| 4015 \| CTD_human CALCA \| 796 \| CTD_human BMPR2 \| 659 \| CTD_human;GHR EDNRB \| 1910 \| CTD_human TGFA \| 7039 \| CTD_human HIF1A \| 3091 \| CTD_human CD40LG \| 959 \| CTD_human ARG2 \| 384 \| CTD_human SMAD9 \| 4093 \| CTD_human CXCL8 \| 3576 \| CTD_human HTR2B \| 3357 \| CTD_human TPH1 \| 7166 \| CTD_human CA9 \| 768 \| CTD_human CBLN2 \| 147381 \| CTD_human CCL1 \| 6346 \| CTD_human MIR204 \| 406987 \| CTD_human
Inferring Gene	Entrez_id \| Symbol \| Resource(Total Genes:13) 659 \| BMPR2 \| infer 2022 \| ENG \| infer 6532 \| SLC6A4 \| infer 4086 \| SMAD1 \| infer 4087 \| SMAD2 \| infer 4088 \| SMAD3 \| infer 4089 \| SMAD4 \| infer 4090 \| SMAD5 \| infer 4091 \| SMAD6 \| infer 7040 \| TGFB1 \| infer 1373 \| CPS1 \| infer 4846 \| NOS3 \| infer 5740 \| PTGIS \| infer
Text Mined Gene	Entrez_id \| Symbol \| Score \| Resource(Total Genes:585) 6376 \| CX3CL1 \| DISEASES 10911 \| UTS2 \| DISEASES 6515 \| SLC2A3 \| DISEASES 9950 \| GOLGA5 \| DISEASES 343641 \| TGM6 \| DISEASES 350 \| APOH \| DISEASES 9942 \| XYLB \| DISEASES 7414 \| VCL \| DISEASES 4282 \| MIF \| DISEASES 1652 \| DDT \| DISEASES 3956 \| LGALS1 \| DISEASES 3162 \| HMOX1 \| DISEASES 5020 \| OXT \| DISEASES 2158 \| F9 \| DISEASES 7076 \| TIMP1 \| DISEASES 4313 \| MMP2 \| DISEASES 3163 \| HMOX2 \| DISEASES 1666 \| DECR1 \| DISEASES 5327 \| PLAT \| DISEASES 3972 \| LHB \| DISEASES 3743 \| KCNA7 \| DISEASES 2217 \| FCGRT \| DISEASES 56729 \| RETN \| DISEASES 2091 \| FBL \| DISEASES 7040 \| TGFB1 \| DISEASES 6822 \| SULT2A1 \| DISEASES 2057 \| EPOR \| DISEASES 57817 \| HAMP \| DISEASES 2077 \| ERF \| DISEASES 3082 \| HGF \| DISEASES 51200 \| CPA4 \| DISEASES 858 \| CAV2 \| DISEASES 5054 \| SERPINE1 \| DISEASES 657 \| BMPR1A \| DISEASES 59 \| ACTA2 \| DISEASES 4353 \| MPO \| DISEASES 1440 \| CSF3 \| DISEASES 5023 \| P2RX1 \| DISEASES 9570 \| GOSR2 \| DISEASES 9527 \| GOSR1 \| DISEASES 6347 \| CCL2 \| DISEASES 1277 \| COL1A1 \| DISEASES 10014 \| HDAC5 \| DISEASES 6783 \| SULT1E1 \| DISEASES 595 \| CCND1 \| DISEASES 5250 \| SLC25A3 \| DISEASES 41 \| ASIC1 \| DISEASES 9761 \| MLEC \| DISEASES 4048 \| LTA4H \| DISEASES 1432 \| MAPK14 \| DISEASES 26235 \| FBXL4 \| DISEASES 55770 \| EXOC2 \| DISEASES 4015 \| LOX \| DISEASES 7035 \| TFPI \| DISEASES 3485 \| IGFBP2 \| DISEASES 4953 \| ODC1 \| DISEASES 1179 \| CLCA1 \| DISEASES 6402 \| SELL \| DISEASES 335 \| APOA1 \| DISEASES 9429 \| ABCG2 \| DISEASES 7043 \| TGFB3 \| DISEASES 1843 \| DUSP1 \| DISEASES 79646 \| PANK3 \| DISEASES 1958 \| EGR1 \| DISEASES 9496 \| TBX4 \| DISEASES 847 \| CAT \| DISEASES 4852 \| NPY \| DISEASES 10268 \| RAMP3 \| DISEASES 7291 \| TWIST1 \| DISEASES 81579 \| PLA2G12A \| DISEASES 5740 \| PTGIS \| DISEASES 1026 \| CDKN1A \| DISEASES 1948 \| EFNB2 \| DISEASES 652 \| BMP4 \| DISEASES 7408 \| VASP \| DISEASES 6945 \| MLX \| DISEASES 2657 \| GDF1 \| DISEASES 2002 \| ELK1 \| DISEASES 6495 \| SIX1 \| DISEASES 92797 \| HELB \| DISEASES 9002 \| F2RL3 \| DISEASES 65997 \| RASL11B \| DISEASES 11135 \| CDC42EP1 \| DISEASES 7166 \| TPH1 \| DISEASES 968 \| CD68 \| DISEASES 1215 \| CMA1 \| DISEASES 112399 \| EGLN3 \| DISEASES 3630 \| INS \| DISEASES 2006 \| ELN \| DISEASES 3741 \| KCNA5 \| DISEASES 59272 \| ACE2 \| DISEASES 2056 \| EPO \| DISEASES 9518 \| GDF15 \| DISEASES 54795 \| TRPM4 \| DISEASES 9584 \| RBM39 \| DISEASES 10266 \| RAMP2 \| DISEASES 6737 \| TRIM21 \| DISEASES 6538 \| SLC6A11 \| DISEASES 10267 \| RAMP1 \| DISEASES 182 \| JAG1 \| DISEASES 1401 \| CRP \| DISEASES 29958 \| DMGDH \| DISEASES 23640 \| HSPBP1 \| DISEASES 377 \| ARF3 \| DISEASES 10468 \| FST \| DISEASES 2922 \| GRP \| DISEASES 187 \| APLNR \| DISEASES 3357 \| HTR2B \| DISEASES 3569 \| IL6 \| DISEASES 3658 \| IREB2 \| DISEASES 4322 \| MMP13 \| DISEASES 7057 \| THBS1 \| DISEASES 1559 \| CYP2C9 \| DISEASES 84171 \| LOXL4 \| DISEASES 6741 \| SSB \| DISEASES 9360 \| PPIG \| DISEASES 490 \| ATP2B1 \| DISEASES 9194 \| SLC16A7 \| DISEASES 28234 \| SLCO1B3 \| DISEASES 10060 \| ABCC9 \| DISEASES 4659 \| PPP1R12A \| DISEASES 7450 \| VWF \| DISEASES 3290 \| HSD11B1 \| DISEASES 1535 \| CYBA \| DISEASES 6532 \| SLC6A4 \| DISEASES 59341 \| TRPV4 \| DISEASES 23184 \| MESDC2 \| DISEASES 5159 \| PDGFRB \| DISEASES 4223 \| MEOX2 \| DISEASES 9172 \| MYOM2 \| DISEASES 4087 \| SMAD2 \| DISEASES 7434 \| VIPR2 \| DISEASES 3674 \| ITGA2B \| DISEASES 6521 \| SLC4A1 \| DISEASES 2294 \| FOXF1 \| DISEASES 28965 \| SLC27A6 \| DISEASES 7224 \| TRPC5 \| DISEASES 25939 \| SAMHD1 \| DISEASES 9132 \| KCNQ4 \| DISEASES 5595 \| MAPK3 \| DISEASES 23293 \| SMG6 \| DISEASES 1 \| A1BG \| DISEASES 50507 \| NOX4 \| DISEASES 3552 \| IL1A \| DISEASES 3553 \| IL1B \| DISEASES 9424 \| KCNK6 \| DISEASES 4854 \| NOTCH3 \| DISEASES 1991 \| ELANE \| DISEASES 6403 \| SELP \| DISEASES 2034 \| EPAS1 \| DISEASES 440275 \| EIF2AK4 \| DISEASES 3791 \| KDR \| DISEASES 6548 \| SLC9A1 \| DISEASES 2983 \| GUCY1B3 \| DISEASES 2247 \| FGF2 \| DISEASES 6774 \| STAT3 \| DISEASES 2255 \| FGF10 \| DISEASES 5443 \| POMC \| DISEASES 50509 \| COL5A3 \| DISEASES 3383 \| ICAM1 \| DISEASES 3827 \| KNG1 \| DISEASES 4883 \| NPR3 \| DISEASES 6722 \| SRF \| DISEASES 5286 \| PIK3C2A \| DISEASES 775 \| CACNA1C \| DISEASES 55089 \| SLC38A4 \| DISEASES 55117 \| SLC6A15 \| DISEASES 6895 \| TARBP2 \| DISEASES 51380 \| CSAD \| DISEASES 11001 \| SLC27A2 \| DISEASES 2252 \| FGF7 \| DISEASES 1583 \| CYP11A1 \| DISEASES 4225 \| MEP1B \| DISEASES 2627 \| GATA6 \| DISEASES 147381 \| CBLN2 \| DISEASES 207 \| AKT1 \| DISEASES 5141 \| PDE4A \| DISEASES 2854 \| GPR32 \| DISEASES 3930 \| LBR \| DISEASES 5972 \| REN \| DISEASES 388 \| RHOB \| DISEASES 805 \| CALM2 \| DISEASES 22989 \| MYH15 \| DISEASES 185 \| AGTR1 \| DISEASES 7220 \| TRPC1 \| DISEASES 1393 \| CRHBP \| DISEASES 3484 \| IGFBP1 \| DISEASES 4841 \| NONO \| DISEASES 8795 \| TNFRSF10B \| DISEASES 1392 \| CRH \| DISEASES 3934 \| LCN2 \| DISEASES 4851 \| NOTCH1 \| DISEASES 196743 \| PAOX \| DISEASES 133 \| ADM \| DISEASES 90952 \| ESAM \| DISEASES 6876 \| TAGLN \| DISEASES 64849 \| SLC13A3 \| DISEASES 114571 \| SLC22A9 \| DISEASES 3606 \| IL18 \| DISEASES 5741 \| PTH \| DISEASES 2321 \| FLT1 \| DISEASES 2697 \| GJA1 \| DISEASES 1360 \| CPB1 \| DISEASES 22934 \| RPIA \| DISEASES 23576 \| DDAH1 \| DISEASES 7547 \| ZIC3 \| DISEASES 6529 \| SLC6A1 \| DISEASES 7079 \| TIMP4 \| DISEASES 5468 \| PPARG \| DISEASES 3156 \| HMGCR \| DISEASES 3815 \| KIT \| DISEASES 4091 \| SMAD6 \| DISEASES 9669 \| EIF5B \| DISEASES 6296 \| ACSM3 \| DISEASES 909 \| CD1A \| DISEASES 11309 \| SLCO2B1 \| DISEASES 1636 \| ACE \| DISEASES 1487 \| CTBP1 \| DISEASES 5739 \| PTGIR \| DISEASES 5152 \| PDE9A \| DISEASES 6285 \| S100B \| DISEASES 5675 \| PSG6 \| DISEASES 6271 \| S100A1 \| DISEASES 5731 \| PTGER1 \| DISEASES 6352 \| CCL5 \| DISEASES 10158 \| PDZK1IP1 \| DISEASES 6006 \| RHCE \| DISEASES 7412 \| VCAM1 \| DISEASES 5937 \| RBMS1 \| DISEASES 3754 \| KCNF1 \| DISEASES 4880 \| NPPC \| DISEASES 84666 \| RETNLB \| DISEASES 213 \| ALB \| DISEASES 5473 \| PPBP \| DISEASES 5196 \| PF4 \| DISEASES 1359 \| CPA3 \| DISEASES 7349 \| UCN \| DISEASES 128 \| ADH5 \| DISEASES 327 \| APEH \| DISEASES 308 \| ANXA5 \| DISEASES 4846 \| NOS3 \| DISEASES 139324 \| HDX \| DISEASES 8642 \| DCHS1 \| DISEASES 5055 \| SERPINB2 \| DISEASES 11318 \| GPR182 \| DISEASES 4665 \| NAB2 \| DISEASES 6778 \| STAT6 \| DISEASES 26585 \| GREM1 \| DISEASES 2923 \| PDIA3 \| DISEASES 10999 \| SLC27A4 \| DISEASES 4775 \| NFATC3 \| DISEASES 94274 \| PPP1R14A \| DISEASES 21 \| ABCA3 \| DISEASES 55867 \| SLC22A11 \| DISEASES 8460 \| TPST1 \| DISEASES 51082 \| POLR1D \| DISEASES 3479 \| IGF1 \| DISEASES 5734 \| PTGER4 \| DISEASES 3308 \| HSPA4 \| DISEASES 8988 \| HSPB3 \| DISEASES 170850 \| KCNG3 \| DISEASES 136 \| ADORA2B \| DISEASES 1448 \| CSN3 \| DISEASES 3596 \| IL13 \| DISEASES 25928 \| SOSTDC1 \| DISEASES 8862 \| APLN \| DISEASES 8436 \| SDPR \| DISEASES 3790 \| KCNS3 \| DISEASES 203100 \| HTRA4 \| DISEASES 2353 \| FOS \| DISEASES 3777 \| KCNK3 \| DISEASES 9836 \| LCMT2 \| DISEASES 9451 \| EIF2AK3 \| DISEASES 112464 \| PRKCDBP \| DISEASES 1241 \| LTB4R \| DISEASES 3787 \| KCNS1 \| DISEASES 54205 \| CYCS \| DISEASES 2147 \| F2 \| DISEASES 5340 \| PLG \| DISEASES 4973 \| OLR1 \| DISEASES 48 \| ACO1 \| DISEASES 1072 \| CFL1 \| DISEASES 171389 \| NLRP6 \| DISEASES 947 \| CD34 \| DISEASES 23479 \| ISCU \| DISEASES 836 \| CASP3 \| DISEASES 7423 \| VEGFB \| DISEASES 358 \| AQP1 \| DISEASES 93107 \| KCNG4 \| DISEASES 54968 \| TMEM70 \| DISEASES 8557 \| TCAP \| DISEASES 3952 \| LEP \| DISEASES 8877 \| SPHK1 \| DISEASES 92745 \| SLC38A5 \| DISEASES 2907 \| GRINA \| DISEASES 3737 \| KCNA2 \| DISEASES 64184 \| EDDM3B \| DISEASES 285 \| ANGPT2 \| DISEASES 1909 \| EDNRA \| DISEASES 10876 \| EDDM3A \| DISEASES 26251 \| KCNG2 \| DISEASES 7094 \| TLN1 \| DISEASES 6440 \| SFTPC \| DISEASES 1442 \| CSH1 \| DISEASES 3291 \| HSD11B2 \| DISEASES 2744 \| GLS \| DISEASES 9377 \| COX5A \| DISEASES 9475 \| ROCK2 \| DISEASES 53905 \| DUOX1 \| DISEASES 27319 \| BHLHE22 \| DISEASES 5912 \| RAP2B \| DISEASES 9120 \| SLC16A6 \| DISEASES 137814 \| NKX2-6 \| DISEASES 9370 \| ADIPOQ \| DISEASES 6863 \| TAC1 \| DISEASES 2149 \| F2R \| DISEASES 54802 \| TRIT1 \| DISEASES 78987 \| CRELD1 \| DISEASES 3039 \| HBA1 \| DISEASES 4312 \| MMP1 \| DISEASES 2837 \| UTS2R \| DISEASES 255520 \| ELMOD2 \| DISEASES 2303 \| FOXC2 \| DISEASES 7433 \| VIPR1 \| DISEASES 4843 \| NOS2 \| DISEASES 5034 \| P4HB \| DISEASES 9241 \| NOG \| DISEASES 10614 \| HEXIM1 \| DISEASES 164684 \| WBP2NL \| DISEASES 9121 \| SLC16A5 \| DISEASES 2894 \| GRID1 \| DISEASES 5155 \| PDGFB \| DISEASES 388962 \| BOLA3 \| DISEASES 71 \| ACTG1 \| DISEASES 5136 \| PDE1A \| DISEASES 6401 \| SELE \| DISEASES 796 \| CALCA \| DISEASES 6546 \| SLC8A1 \| DISEASES 4088 \| SMAD3 \| DISEASES 2689 \| GH2 \| DISEASES 5104 \| SERPINA5 \| DISEASES 348235 \| SKA2 \| DISEASES 10057 \| ABCC5 \| DISEASES 3043 \| HBB \| DISEASES 2152 \| F3 \| DISEASES 8912 \| CACNA1H \| DISEASES 2626 \| GATA4 \| DISEASES 51738 \| GHRL \| DISEASES 3320 \| HSP90AA1 \| DISEASES 957 \| ENTPD5 \| DISEASES 1908 \| EDN3 \| DISEASES 4842 \| NOS1 \| DISEASES 10011 \| SRA1 \| DISEASES 57142 \| RTN4 \| DISEASES 1576 \| CYP3A4 \| DISEASES 3363 \| HTR7 \| DISEASES 3091 \| HIF1A \| DISEASES 23583 \| SMUG1 \| DISEASES 66005 \| CHID1 \| DISEASES 3266 \| ERAS \| DISEASES 857 \| CAV1 \| DISEASES 6540 \| SLC6A13 \| DISEASES 7060 \| THBS4 \| DISEASES 8459 \| TPST2 \| DISEASES 23767 \| FLRT3 \| DISEASES 4128 \| MAOA \| DISEASES 7225 \| TRPC6 \| DISEASES 4882 \| NPR2 \| DISEASES 11317 \| RBPJL \| DISEASES 1528 \| CYB5A \| DISEASES 7137 \| TNNI3 \| DISEASES 344901 \| OSTN \| DISEASES 259307 \| IL4I1 \| DISEASES 10811 \| NOXA1 \| DISEASES 866 \| SERPINA6 \| DISEASES 3146 \| HMGB1 \| DISEASES 7273 \| TTN \| DISEASES 1003 \| CDH5 \| DISEASES 1499 \| CTNNB1 \| DISEASES 56479 \| KCNQ5 \| DISEASES 6275 \| S100A4 \| DISEASES 5154 \| PDGFA \| DISEASES 23481 \| PES1 \| DISEASES 133584 \| EGFLAM \| DISEASES 8654 \| PDE5A \| DISEASES 375346 \| TMEM110 \| DISEASES 50488 \| MINK1 \| DISEASES 57591 \| MKL1 \| DISEASES 5265 \| SERPINA1 \| DISEASES 3240 \| HP \| DISEASES 146059 \| CDAN1 \| DISEASES 273 \| AMPH \| DISEASES 80228 \| ORAI2 \| DISEASES 55871 \| CBWD1 \| DISEASES 5733 \| PTGER3 \| DISEASES 3042 \| HBM \| DISEASES 60 \| ACTB \| DISEASES 871 \| SERPINH1 \| DISEASES 6714 \| SRC \| DISEASES 1524 \| CX3CR1 \| DISEASES 1969 \| EPHA2 \| DISEASES 405 \| ARNT \| DISEASES 5139 \| PDE3A \| DISEASES 343173 \| OR2T3 \| DISEASES 26275 \| HIBCH \| DISEASES 4151 \| MB \| DISEASES 7037 \| TFRC \| DISEASES 2157 \| F8 \| DISEASES 4638 \| MYLK \| DISEASES 4311 \| MME \| DISEASES 2993 \| GYPA \| DISEASES 7150 \| TOP1 \| DISEASES 2475 \| MTOR \| DISEASES 5742 \| PTGS1 \| DISEASES 54510 \| PCDH18 \| DISEASES 9937 \| DCLRE1A \| DISEASES 23038 \| WDTC1 \| DISEASES 961 \| CD47 \| DISEASES 6262 \| RYR2 \| DISEASES 54583 \| EGLN1 \| DISEASES 183 \| AGT \| DISEASES 200205 \| IBA57 \| DISEASES 6648 \| SOD2 \| DISEASES 7432 \| VIP \| DISEASES 7139 \| TNNT2 \| DISEASES 5788 \| PTPRC \| DISEASES 5743 \| PTGS2 \| DISEASES 4688 \| NCF2 \| DISEASES 462 \| SERPINC1 \| DISEASES 1490 \| CTGF \| DISEASES 383 \| ARG1 \| DISEASES 911 \| CD1C \| DISEASES 2117 \| ETV3 \| DISEASES 116150 \| NUS1 \| DISEASES 11000 \| SLC27A3 \| DISEASES 4881 \| NPR1 \| DISEASES 6566 \| SLC16A1 \| DISEASES 3744 \| KCNA10 \| DISEASES 3351 \| HTR1B \| DISEASES 1244 \| ABCC2 \| DISEASES 22802 \| CLCA4 \| DISEASES 9635 \| CLCA2 \| DISEASES 2258 \| FGF13 \| DISEASES 959 \| CD40LG \| DISEASES 1491 \| CTH \| DISEASES 1791 \| DNTT \| DISEASES 3725 \| JUN \| DISEASES 23203 \| PMPCA \| DISEASES 3745 \| KCNB1 \| DISEASES 186 \| AGTR2 \| DISEASES 5728 \| PTEN \| DISEASES 7422 \| VEGFA \| DISEASES 729238 \| SFTPA2 \| DISEASES 4318 \| MMP9 \| DISEASES 1907 \| EDN2 \| DISEASES 27035 \| NOX1 \| DISEASES 2022 \| ENG \| DISEASES 2170 \| FABP3 \| DISEASES 7099 \| TLR4 \| DISEASES 5592 \| PRKG1 \| DISEASES 240 \| ALOX5 \| DISEASES 1896 \| EDA \| DISEASES 659 \| BMPR2 \| DISEASES 8518 \| IKBKAP \| DISEASES 1889 \| ECE1 \| DISEASES 7046 \| TGFBR1 \| DISEASES 4855 \| NOTCH4 \| DISEASES 84909 \| C9orf3 \| DISEASES 25805 \| BAMBI \| DISEASES 23564 \| DDAH2 \| DISEASES 3055 \| HCK \| DISEASES 3397 \| ID1 \| DISEASES 4879 \| NPPB \| DISEASES 4878 \| NPPA \| DISEASES 10257 \| ABCC4 \| DISEASES 5394 \| EXOSC10 \| DISEASES 7056 \| THBD \| DISEASES 1910 \| EDNRB \| DISEASES 221074 \| SLC39A12 \| DISEASES 64344 \| HIF3A \| DISEASES 688 \| KLF5 \| DISEASES 9356 \| SLC22A6 \| DISEASES 3980 \| LIG3 \| DISEASES 1536 \| CYBB \| DISEASES 3356 \| HTR2A \| DISEASES 650 \| BMP2 \| DISEASES 5251 \| PHEX \| DISEASES 1906 \| EDN1 \| DISEASES 2308 \| FOXO1 \| DISEASES 7222 \| TRPC3 \| DISEASES 7223 \| TRPC4 \| DISEASES 1059 \| CENPB \| DISEASES 23309 \| SIN3B \| DISEASES 4093 \| SMAD9 \| DISEASES 7010 \| TEK \| DISEASES 247 \| ALOX15B \| DISEASES 551 \| AVP \| DISEASES 5277 \| PIGA \| DISEASES 3486 \| IGFBP3 \| DISEASES 3717 \| JAK2 \| DISEASES 6649 \| SOD3 \| DISEASES 23410 \| SIRT3 \| DISEASES 79400 \| NOX5 \| DISEASES 94 \| ACVRL1 \| DISEASES 50506 \| DUOX2 \| DISEASES 6263 \| RYR3 \| DISEASES 440193 \| CCDC88C \| DISEASES 2524 \| FUT2 \| DISEASES 5077 \| PAX3 \| DISEASES 10203 \| CALCRL \| DISEASES 114805 \| GALNT13 \| DISEASES 1443 \| CSH2 \| DISEASES 143187 \| VTI1A \| DISEASES 6439 \| SFTPB \| DISEASES 6696 \| SPP1 \| DISEASES 2643 \| GCH1 \| DISEASES 79924 \| ADM2 \| DISEASES 6387 \| CXCL12 \| DISEASES 831 \| CAST \| DISEASES 4773 \| NFATC2 \| DISEASES 5137 \| PDE1C \| DISEASES 54704 \| PDP1 \| DISEASES 4629 \| MYH11 \| DISEASES 144195 \| SLC2A14 \| DISEASES 4357 \| MPST \| DISEASES 55234 \| SMU1 \| DISEASES 23365 \| ARHGEF12 \| DISEASES 5609 \| MAP2K7 \| DISEASES 319 \| APOF \| DISEASES 81539 \| SLC38A1 \| DISEASES 25923 \| ATL3 \| DISEASES 6093 \| ROCK1 \| DISEASES 25974 \| MMACHC \| DISEASES 1617 \| DAZ1 \| DISEASES 51571 \| FAM49B \| DISEASES 5150 \| PDE7A \| DISEASES 7018 \| TF \| DISEASES 7852 \| CXCR4 \| DISEASES 501 \| ALDH7A1 \| DISEASES 27247 \| NFU1 \| DISEASES 4295 \| MLN \| DISEASES 3112 \| HLA-DOB \| DISEASES 3481 \| IGF2 \| DISEASES 6915 \| TBXA2R \| DISEASES 115677 \| NOSTRIN \| DISEASES 1195 \| CLK1 \| DISEASES 29843 \| SENP1 \| DISEASES 653509 \| SFTPA1 \| DISEASES 279 \| AMY2A \| DISEASES 7124 \| TNF \| DISEASES 387 \| RHOA \| DISEASES 57135 \| DAZ4 \| DISEASES 93649 \| MYOCD \| DISEASES 5817 \| PVR \| DISEASES 3586 \| IL10 \| DISEASES 8842 \| PROM1 \| DISEASES 57553 \| MICAL3 \| DISEASES 2801 \| GOLGA2 \| DISEASES 6513 \| SLC2A1 \| DISEASES 85474 \| LBX2 \| DISEASES 57620 \| STIM2 \| DISEASES 347273 \| MURC \| DISEASES 5478 \| PPIA \| DISEASES 846 \| CASR \| DISEASES 2317 \| FLNB \| DISEASES 11267 \| SNF8 \| DISEASES 114907 \| FBXO32 \| DISEASES 253970 \| SFTA3 \| DISEASES 284 \| ANGPT1 \| DISEASES 137075 \| CLDN23 \| DISEASES 149466 \| C1orf210 \| DISEASES 10480 \| EIF3M \| DISEASES 3987 \| LIMS1 \| DISEASES 8972 \| MGAM \| DISEASES 5053 \| PAH \| DISEASES 5228 \| PGF \| DISEASES 388588 \| SMIM1 \| DISEASES 9294 \| S1PR2 \| DISEASES 7138 \| TNNT1 \| DISEASES 54938 \| SARS2 \| DISEASES 6625 \| SNRNP70 \| DISEASES 400550 \| FENDRR \| DISEASES 102723508 \| KANTR \| DISEASES 94161 \| SNORD46 \| DISEASES 26785 \| SNORD63 \| DISEASES
Locus	(Waiting for update.)

Disease ID	660
Disease	pulmonary hypertension
Integrated Phenotype	(Waiting for update.)
Text Mined Phenotype	HPO \| Name \| Sentences' Count(Total Phenotypes:186) HP:0001635 \| Congestive heart failure \| 81 HP:0006510 \| Chronic obstructive pulmonary disease \| 33 HP:0001631 \| Atria septal defect \| 21 HP:0002206 \| Pulmonary fibrosis \| 21 HP:0005180 \| Tricuspid insufficiency \| 19 HP:0006530 \| Interstitial lung disease \| 18 HP:0001708 \| Impaired right ventricular function \| 16 HP:0002878 \| Respiratory failure \| 15 HP:0000776 \| Diaphragmatic hernia \| 15 HP:0000822 \| Hypertension \| 13 HP:0001714 \| Ventricular hypertrophy \| 12 HP:0002725 \| Systemic lupus erythematosus \| 12 HP:0012418 \| Low blood oxygen level \| 11 HP:0001643 \| Persistent ductus arteriosus \| 11 HP:0001667 \| Right ventricular hypertrophy \| 10 HP:0100324 \| Progressive systemic scleroderma \| 10 HP:0001638 \| Cardiomyopathy \| 9 HP:0001648 \| Cor pulmonale \| 8 HP:0002097 \| Pulmonary emphysema \| 8 HP:0006528 \| Chronic lung disease \| 8 HP:0002204 \| Pulmonary embolism \| 7 HP:0100790 \| Hernia \| 7 HP:0001907 \| Thromboembolic disease \| 7 HP:0002098 \| Respiratory distress \| 6 HP:0001650 \| Valvular aortic stenosis \| 6 HP:0006536 \| Obstructive lung disease \| 6 HP:0010535 \| Sleep apnea \| 6 HP:0002104 \| Absence of spontaneous respiration \| 6 HP:0001903 \| Anemia \| 5 HP:0002615 \| Low blood pressure \| 5 HP:0012382 \| Left-to-right shunt \| 5 HP:0001653 \| Mitral valve insufficiency \| 5 HP:0001627 \| Congenital heart defects \| 5 HP:0004937 \| Pulmonary artery aneurysm \| 5 HP:0001878 \| Haemolytic anaemia \| 5 HP:0001669 \| Transposition of the great arteries \| 4 HP:0005317 \| Increased pulmonary vascular resistance \| 4 HP:0012622 \| Chronic kidney disease \| 4 HP:0002664 \| Neoplasia \| 4 HP:0001718 \| Mitral stenosis \| 4 HP:0003774 \| End-stage renal failure \| 4 HP:0000961 \| Cyanosis \| 4 HP:0002094 \| Dyspnea \| 4 HP:0002089 \| Hypoplastic lungs \| 4 HP:0002617 \| Aneurysmal dilatation \| 4 HP:0001394 \| Hepatic cirrhosis \| 4 HP:0001694 \| Right-to-left shunt \| 4 HP:0002090 \| Pneumonia \| 4 HP:0002093 \| progressive respiratory failure \| 4 HP:0000969 \| Dropsy \| 3 HP:0011675 \| Arrhythmias \| 3 HP:0100033 \| Tic disorder \| 3 HP:0001629 \| Ventricular septal defects \| 3 HP:0002721 \| Immunodeficiency \| 3 HP:0002791 \| Under breathing \| 3 HP:0002597 \| Abnormality of blood vessels \| 3 HP:0011950 \| Bronchiolitis \| 3 HP:0005547 \| Myeloproliferative disorder \| 3 HP:0001671 \| Abnormality of the cardiac septa \| 3 HP:0004870 \| hemolytic anemia, chronic \| 3 HP:0000836 \| Overactive thyroid \| 3 HP:0000716 \| Depression \| 2 HP:0002870 \| Obstructive sleep apnea \| 2 HP:0002835 \| Aspiration \| 2 HP:0001685 \| Myocardial fibrosis \| 2 HP:0004749 \| Atrial flutter \| 2 HP:0012531 \| Pain \| 2 HP:0100727 \| Histiocytosis \| 2 HP:0001640 \| Increased heart size \| 2 HP:0001677 \| Coronary artery disease \| 2 HP:0001409 \| Portal hypertension \| 2 HP:0004415 \| Pulmonary artery stenosis \| 2 HP:0005110 \| Atrial fibrillation \| 2 HP:0002902 \| Hyponatremia \| 2 HP:0001009 \| Telangiectases \| 2 HP:0001511 \| Prenatal onset growth retardation \| 2 HP:0000867 \| Secondary hyperparathyroidism \| 2 HP:0000093 \| Proteinuria \| 2 HP:0006685 \| Endocardial fibrosis \| 2 HP:0011946 \| Constrictive bronchiolitis \| 2 HP:0100724 \| Hypercoagulability \| 2 HP:0002960 \| Autoimmune condition \| 2 HP:0005306 \| Capillary hemangioma \| 2 HP:0000739 \| Anxiety \| 2 HP:0001399 \| Liver failure \| 2 HP:0000843 \| Hyperparathyroidism \| 2 HP:0001723 \| Restrictive cardiomyopathy \| 2 HP:0002633 \| Vasculitis \| 2 HP:0001644 \| Congestive cardiomyopathy \| 2 HP:0010773 \| Partial anomalous pulmonary venous return \| 2 HP:0005954 \| Pulmonary capillary hemangiomatosis \| 2 HP:0001513 \| Obesity \| 2 HP:0100598 \| Pulmonary oedema \| 2 HP:0010772 \| Anomalous pulmonary venous return \| 2 HP:0004818 \| Paroxysmal nocturnal hemoglobinuria \| 1 HP:0005912 \| Biliary duct atresia \| 1 HP:0012387 \| Bronchitis \| 1 HP:0001928 \| Abnormal blood coagulation studies \| 1 HP:0030149 \| Cardiovascular shock \| 1 HP:0005133 \| Right ventricular dilatation \| 1 HP:0100827 \| Lymphocytosis \| 1 HP:0000768 \| Pectus carinatum \| 1 HP:0001639 \| Hypertrophic cardiomyopathy \| 1 HP:0000112 \| Nephropathy \| 1 HP:0001510 \| Growth deficiency \| 1 HP:0002643 \| Respiratory distress, neonatal \| 1 HP:0001999 \| Facial dysmorphism \| 1 HP:0004395 \| Malnutrition \| 1 HP:0000713 \| Agitation \| 1 HP:0001067 \| Neurofibromas \| 1 HP:0001370 \| Rheumatoid arthritis \| 1 HP:0030049 \| Brain abscess \| 1 HP:0004756 \| Ventricular tachycardia \| 1 HP:0001698 \| Pericardial effusions \| 1 HP:0002751 \| Kyphoscoliosis \| 1 HP:0002170 \| Intracranial hemorrhage \| 1 HP:0001894 \| Thrombocytosis \| 1 HP:0002877 \| Nocturnal under breathing \| 1 HP:0040213 \| Hypopnea \| 1 HP:0011974 \| Myelofibrosis \| 1 HP:0001681 \| Angina pectoris \| 1 HP:0000572 \| Visual loss \| 1 HP:0002613 \| Biliary cirrhosis \| 1 HP:0002027 \| Abdominal pain \| 1 HP:0001659 \| Aortic insufficiency \| 1 HP:0001636 \| Tetrology of fallot \| 1 HP:0001655 \| Patent foramen ovale \| 1 HP:0012516 \| Tetralogy of Fallot with pulmonary atresia \| 1 HP:0004929 \| Coronary artherosclerosis \| 1 HP:0005549 \| Low blood neutrophil level since birth \| 1 HP:0100510 \| Vitamin C deficiency \| 1 HP:0004927 \| Pulmonary artery dilatation \| 1 HP:0012304 \| Hypoplastic aortic arch \| 1 HP:0005310 \| Large vessel vasculitis \| 1 HP:0002621 \| Atherosclerosis \| 1 HP:0010310 \| Chylothorax \| 1 HP:0012721 \| Venous malformations \| 1 HP:0005162 \| Left ventricular impairment \| 1 HP:0001642 \| Pulmonic stenosis \| 1 HP:0100584 \| Endocarditis \| 1 HP:0001217 \| Digital clubbing \| 1 HP:0012416 \| Hypercarbia \| 1 HP:0100026 \| Arteriovenous malformation \| 1 HP:0001645 \| Sudden cardiac death \| 1 HP:0011499 \| Mydriasis \| 1 HP:0002099 \| Asthma \| 1 HP:0000078 \| Genital abnormalities \| 1 HP:0001684 \| Secundum atrial septal defect \| 1 HP:0100867 \| Duodenal stenosis/atresia \| 1 HP:0002105 \| Hemoptysis \| 1 HP:0012115 \| Liver inflammation \| 1 HP:0006574 \| Liver arteriovenous malformation \| 1 HP:0002240 \| Enlarged liver \| 1 HP:0006772 \| Angiomyolipoma \| 1 HP:0030357 \| Small cell lung carcinoma \| 1 HP:0100749 \| Thoracic pain \| 1 HP:0011662 \| Tricuspid atresia \| 1 HP:0002634 \| Arteriosclerosis \| 1 HP:0002092 \| Pulmonary artery hypertension \| 1 HP:0000047 \| Hypospadias \| 1 HP:0002955 \| Granulomatosis \| 1 HP:0001518 \| Small for gestational age \| 1 HP:0004969 \| peripheral pulmonary stenosis \| 1 HP:0012196 \| Periodic respiration \| 1 HP:0003765 \| Psoriasis \| 1 HP:0012383 \| Bidirectional shunt \| 1 HP:0002138 \| Subarachnoid hemorrhage \| 1 HP:0100806 \| Sepsis \| 1 HP:0011903 \| Hemoglobin H \| 1 HP:0002797 \| Increased bone resorption \| 1 HP:0001695 \| Cardiac arrest \| 1 HP:0030666 \| Retinal neovascularisation \| 1 HP:0005294 \| Arterial dissection \| 1 HP:0030812 \| Tonsillar hypertrophy \| 1 HP:0000726 \| Dementia \| 1 HP:0030358 \| Non-small cell lung carcinoma \| 1 HP:0005132 \| Pericardial constriction \| 1 HP:0001875 \| Neutropenia \| 1 HP:0004755 \| Supraventricular tachycardia \| 1 HP:0002119 \| Ventricular dilatation \| 1 HP:0002487 \| Muscle spasms \| 1 HP:0003390 \| Sensory axonal neuropathy \| 1 HP:0001712 \| Left ventricular hypertrophy \| 1 HP:0100647 \| Morbus Basedow \| 1 HP:0001298 \| Encephalopathy \| 1 HP:0011665 \| Takotsubo cardiomyopathy \| 1

Disease ID	660
Disease	pulmonary hypertension
Manually Symptom	(Waiting for update.)
Text Mined Symptom	UMLS \| Name \| Sentences' Count(Total Symptoms:56) C0018801 \| heart failure \| 77 C0152021 \| congenital heart disease \| 39 C0024117 \| chronic obstructive pulmonary disease \| 33 C0024115 \| pulmonary disease \| 28 C0232605 \| regurgitation \| 19 C0235527 \| right heart failure \| 18 C0426768 \| o sign \| 16 C1145670 \| respiratory failure \| 15 C0235527 \| right ventricular failure \| 14 C0018817 \| atrial septal defect \| 14 C0024115 \| lung diseases \| 14 C0024141 \| systemic lupus erythematosus \| 12 C0162770 \| right ventricular hypertrophy \| 10 C0034072 \| cor pulmonale \| 8 C0034065 \| pulmonary embolism \| 7 C0856169 \| endothelial dysfunction \| 7 C0013922 \| embolism \| 7 C0042373 \| vascular disease \| 5 C0035229 \| respiratory insufficiency \| 4 C0040961 \| tricuspid insufficiency \| 4 C0013404 \| dyspnea \| 4 C0018799 \| cardiac disease \| 4 C0018801 \| cardiac failure \| 3 C0002940 \| aneurysm \| 3 C0020550 \| hyperthyroidism \| 3 C0040053 \| thrombus \| 3 C0427008 \| stiffness \| 3 C0018816 \| septal defects \| 3 C0796095 \| c syndrome \| 3 C0020503 \| secondary hyperparathyroidism \| 2 C0030193 \| pain \| 2 C0021308 \| infarction \| 2 C1562095 \| right ventricular systolic dysfunction \| 2 C0011570 \| depression \| 2 C0748168 \| pulmonary pathology \| 2 C0685095 \| biventricular failure \| 2 C1444565 \| cardiopulmonary failure \| 2 C0264715 \| acute right heart failure \| 2 C0232197 \| fibrillation \| 2 C0018818 \| ventricular septal defect \| 2 C0018799 \| heart diseases \| 2 C0006017 \| pertussis \| 1 C0034067 \| pulmonary emphysema \| 1 C0013404 \| dyspnoea \| 1 C0422833 \| ent symptoms \| 1 C0235527 \| right-sided heart failure \| 1 C0036690 \| sepsis \| 1 C0034063 \| pulmonary edema \| 1 C0024115 \| pulmonary disorders \| 1 C0016522 \| patent foramen ovale \| 1 C0008031 \| chest pain \| 1 C0013404 \| shortness of breath \| 1 C0018818 \| ventricular septal defects \| 1 C0040053 \| thrombosis \| 1 C0031039 \| pericardial effusion \| 1 C0085404 \| crow-fukase syndrome \| 1

Manually Genotype(Total Text Mining Genotypes:0)
(Waiting for update.)

All Snps(Total Genotypes:7)
snpId	pubmedId	geneId	geneSymbol	diseaseId	sourceId	sentence	score	Year	geneSymbol_dbSNP	CHROMOSOME	POS	REF	ALT
rs1047891	17188582	1373	CPS1	umls:C0020542	BeFree	A well-characterized polymorphism in the gene encoding CPSI (T1405N) has previously been implicated in neonatal pulmonary hypertension.	0.002638474	2007	CPS1	2	210675783	C	A
rs121912594	17188582	1373	CPS1	umls:C0020542	BeFree	A well-characterized polymorphism in the gene encoding CPSI (T1405N) has previously been implicated in neonatal pulmonary hypertension.	0.002638474	2007	CPS1	2	210675762	A	C
rs137852741	22936709	659	BMPR2	umls:C0020542	BeFree	Bmpr2(R899X) mice fed a high-fat diet had strong increases in pulmonary hypertension penetrance (seven out of 11 versus three out of 11).	0.160601574	2013	BMPR2	2	202556360	C	G,T
rs1799983	21144100	4846	NOS3	umls:C0020542	BeFree	Endothelial nitric oxide synthase gene polymorphism (Glu298Asp) and acute pulmonary hypertension post cardiopulmonary bypass in children with congenital cardiac diseases.	0.207448483	2011	NOS3	7	150999023	T	G
rs201558687	25373139	2982	GUCY1A3	umls:C0020542	BeFree	α1-A680T variant in GUCY1A3 as a candidate conferring protection from pulmonary hypertension among Kyrgyz highlanders.	0.000271442	2015	GUCY1A3;LOC105377506	4	155730196	G	A
rs2249825	25050807	3146	HMGB1	umls:C0020542	BeFree	Our finding suggests that rs2249825 of HMGB1 genetic polymorphisms are significantly associated with HT and diastolic blood pressure, and the genetic effect on HT is modulated by age.	0.080814326	2015	HMGB1	13	30463766	G	C,A
rs2249825	25050807	2638	GC	umls:C0020542	BeFree	Quantitative trait analysis indicated that DBP had a linear decrease with the variations of rs2249825 in both untreated HT group (p=0.002) and control group (p=0.034) respectively.	0.000271442	2015	HMGB1	13	30463766	G	C,A

GWASdb Annotation(Total Genotypes:0)
(Waiting for update.)

GWASdb Snp Trait(Total Genotypes:1)
CHR	POS	SNPID	REF	ALT	ORI_SNPID	PMID	P_VALUE	P_VALUE_TEXT	OR/BETA	CI95_TEXT	GWAS_INITIAL_SAMPLE_SIZE	SUB_POPULATION	SUPER_POPULATION	GWAS_TRAIT	HPO_ID	HPO_TERM	DO_ID	DO_TERM	MESH_ID	MESH_TERM	EFO_ID	EFO_TERM	DOLITE_TERM	RISK_ALLELE	PUBLICATION_TYPE	AA	GENE_SYMBOL	TYPE	REFGENE
18	70150939	rs2217560	G	A	rs2217560	23502781	7.00E-10	NA	1.97	[1.59-2.45]	340 European ancestry cases; 1,068 European ancestry controls	European(1408)	ALL(1408)	EUR(1408)	ALL(1408)	Pulmonary arterial hypertension (without BMPR2 mutations)	HPOID:0002092	Pulmonary hypertension	DOID:6432	pulmonary hypertension	NA	NA	EFOID:0001361	pulmonary hypertension	Pulmonary hypertension	rs2217560-G	Research Support, N.I.H., Extramural	Research Support, Non-U.S. Gov't	Comparative Study

Mapped by lexical matching(Total Items:0)
(Waiting for update.)

Mapped by homologous gene(Total Items:0)
(Waiting for update.)

Chemical(Total Drugs:37)
CUI	ChemicalName	ChemicalID	CasRN	DiseaseName	DiseaseID	DirectEvidence	PubMedIDs
C0020542	ambrisentan	C467894	177036-94-1	hypertension, pulmonary	MESH:D006976	therapeutic	16219361
C0020542	amphetamine	D000661	300-62-9	hypertension, pulmonary	MESH:D006976	marker/mechanism	15960135
C0020542	bleomycin	D001761	11056-06-7	hypertension, pulmonary	MESH:D006976	marker/mechanism	12003776
C0020542	bosentan	C086232	147536-97-8	hypertension, pulmonary	MESH:D006976	therapeutic	10353441
C0020542	enalapril	D004656	75847-73-3	hypertension, pulmonary	MESH:D006976	therapeutic	12003776
C0020542	fenfluramine	D005277	458-24-2	hypertension, pulmonary	MESH:D006976	marker/mechanism	10383810
C0020542	fluoxetine	D005473	54910-89-3	hypertension, pulmonary	MESH:D006976	marker/mechanism	17702969
C0020542	fluoxetine	D005473	54910-89-3	hypertension, pulmonary	MESH:D006976	therapeutic	19298536
C0020542	gefitinib	C419708	184475-35-2	hypertension, pulmonary	MESH:D006976	therapeutic	18424623
C0020542	hydroxyurea	D006918	127-07-1	hypertension, pulmonary	MESH:D006976	therapeutic	19077048
C0020542	indomethacin	D007213	53-86-1	hypertension, pulmonary	MESH:D006976	marker/mechanism	11340680
C0020542	indomethacin	D007213	53-86-1	hypertension, pulmonary	MESH:D006976	therapeutic	14668575
C0020542	macitentan	C533860	-	hypertension, pulmonary	MESH:D006976	therapeutic	26111581
C0020542	mazindol	D008454	22232-71-9	hypertension, pulmonary	MESH:D006976	marker/mechanism	10732856
C0020542	methylphenidate	D008774	113-45-1	hypertension, pulmonary	MESH:D006976	marker/mechanism	20578938
C0020542	metoprolol	D008790	37350-58-6	hypertension, pulmonary	MESH:D006976	therapeutic	20508210
C0020542	milrinone	D020105	78415-72-2	hypertension, pulmonary	MESH:D006976	therapeutic	10226902
C0020542	minoxidil	D008914	38304-91-5	hypertension, pulmonary	MESH:D006976	therapeutic	16544967
C0020542	nicotine	D009538	-	hypertension, pulmonary	MESH:D006976	marker/mechanism	16499655
C0020542	nimodipine	D009553	66085-59-4	hypertension, pulmonary	MESH:D006976	marker/mechanism	1599066
C0020542	nitric oxide	D009569	10102-43-9	hypertension, pulmonary	MESH:D006976	marker/mechanism	10089252
C0020542	nitric oxide	D009569	10102-43-9	hypertension, pulmonary	MESH:D006976	therapeutic	10071995
C0020542	nitroprusside	D009599	15078-28-1	hypertension, pulmonary	MESH:D006976	therapeutic	15278610
C0020542	norepinephrine	D009638	51-41-2	hypertension, pulmonary	MESH:D006976	marker/mechanism	7549228
C0020542	octreotide	D015282	83150-76-9	hypertension, pulmonary	MESH:D006976	marker/mechanism	12596116
C0020542	paclitaxel	D017239	-	hypertension, pulmonary	MESH:D006976	marker/mechanism	11422257
C0020542	phentermine	D010645	122-09-8	hypertension, pulmonary	MESH:D006976	marker/mechanism	10383810
C0020542	phenylpropanolamine	D010665	14838-15-4	hypertension, pulmonary	MESH:D006976	marker/mechanism	15201268
C0020542	propranolol	D011433	525-66-6	hypertension, pulmonary	MESH:D006976	therapeutic	3344727
C0020542	epoprostenol	D011464	35121-78-9	hypertension, pulmonary	MESH:D006976	therapeutic	10710749
C0020542	ritonavir	D019438	-	hypertension, pulmonary	MESH:D006976	marker/mechanism	19114959
C0020542	rosiglitazone	C089730	-	hypertension, pulmonary	MESH:D006976	therapeutic	19520921
C0020542	thalidomide	D013792	50-35-1	hypertension, pulmonary	MESH:D006976	marker/mechanism	12670354
C0020542	treprostinil	C427248	-	hypertension, pulmonary	MESH:D006976	therapeutic	20522807
C0020542	valproic acid	D014635	99-66-1	hypertension, pulmonary	MESH:D006976	therapeutic	22711276
C0020542	vorinostat	C111237	-	hypertension, pulmonary	MESH:D006976	therapeutic	22711276
C0020542	zafirlukast	C062735	107753-78-6	hypertension, pulmonary	MESH:D006976	therapeutic	12781059

FDA approved drug and dosage information(Total Drugs:0)
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FDA labeling changes(Total Drugs:0)
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