PedAM

Pediatric Disease Annotations & Medicines


	pulmonary disease, chronic obstructive

Disease ID	1888
Disease	pulmonary disease, chronic obstructive
Synonym	not otherwise specified #NAME? airway small disease airways diseases small cafl - chronic airflow limitation cal - chronic airflow limitation chronic airflow limitation chronic airway disease chronic airway obstruction chronic airways disease chronic irreversible airway obstruction chronic obstructive airway dis chronic obstructive airway disease chronic obstructive airways disease chronic obstructive airways disease nos chronic obstructive airways disease nos (disorder) chronic obstructive lung dis chronic obstructive lung disease chronic obstructive lung disease (disorder) chronic obstructive lung disease [ambiguous] chronic obstructive lung disease, nos chronic obstructive pulm dis chronic obstructive pulmonary disease chronic obstructive pulmonary disease (copd) chronic obstructive pulmonary disease finding chronic obstructive pulmonary disease finding (finding) chronic obstructive pulmonary disease nos chronic obstructive pulmonary disease, (copd) coad coad - chronic obstructive airways disease cold (chronic obstructive lung disease) cold - chronic obstructive lung disease copd copd - chronic obstructive pulmonary disease copd nos copd, chronic obstructive pulmonary disease disease (copd), chronic obstructive hyperactive airway disease obstructive pulmonary disease (copd), chronic pulm dis chronic obstructive pulmonary disease (copd), chronic obstructive pulmonary disease, chronic obstructive [disease/finding] small airway disease small airways disease
OMIM	OMIM:606963
DOID	DOID:3083
MeSH	D029424
SNOMED-CT	SNOMEDCT_US_2016_09_01:13645005
Curated Gene	Entrez_id \| Symbol \| Resource(Total Genes:50) TNF \| 7124 \| CTD_human NOS3 \| 4846 \| CTD_human TP53 \| 7157 \| CTD_human TGFB1 \| 7040 \| CTD_human EPHX1 \| 2052 \| CTD_human FAM13A \| 10144 \| CTD_human;GWASCAT MMP1 \| 4312 \| CTD_human HMOX1 \| 3162 \| CTD_human MMP9 \| 4318 \| CTD_human TRPV4 \| 59341 \| CTD_human NOS2 \| 4843 \| CTD_human FAM19A2 \| 338811 \| GWASCAT HLA-C \| 3107 \| GWASCAT SOD3 \| 6649 \| CTD_human SFTPD \| 6441 \| GWASCAT TGFB2 \| 7042 \| GWASCAT CSMD1 \| 64478 \| GWASCAT SERPINA1 \| 5265 \| CTD_human HTR2A \| 3356 \| CTD_human CHRNA3 \| 1136 \| GWASCAT SCGB1A1 \| 7356 \| GWASCAT ANXA11 \| 311 \| GWASCAT CHRNA5 \| 1138 \| GWASCAT TNNT2 \| 7139 \| CTD_human CD8A \| 925 \| CTD_human SCLT1 \| 132320 \| GWASCAT CYP1A1 \| 1543 \| CTD_human CYS1 \| 192668 \| GWASCAT HDAC2 \| 3066 \| CTD_human RAPGEF3 \| 10411 \| CTD_human CFAP221 \| 200373 \| GWASCAT CXCL8 \| 3576 \| CTD_human MIR99AHG \| 388815 \| GWASCAT PSORS1C2 \| 170680 \| GWASCAT PSORS1C1 \| 170679 \| GWASCAT ASRGL1 \| 80150 \| GWASCAT RIN3 \| 79890 \| GWASCAT TMEM254 \| 80195 \| GWASCAT HYKK \| 123688 \| GWASCAT MIA-RAB4B \| 100529262 \| GWASCAT MMP14 \| 4323 \| CTD_human CYP1A2 \| 1544 \| CTD_human IREB2 \| 3658 \| GWASCAT ATP2C2 \| 9914 \| GWASCAT CD151 \| 977 \| GWASCAT RAB4B-EGLN2 \| 100529264 \| GWASCAT CRACR2B \| 283229 \| GWASCAT DLG2 \| 1740 \| GWASCAT RNF150 \| 57484 \| GWASCAT NUPL2 \| 11097 \| GWASCAT
Inferring Gene	Entrez_id \| Symbol \| Resource(Total Genes:442) 19 \| ABCA1 \| infer 23461 \| ABCA5 \| infer 23460 \| ABCA6 \| infer 10347 \| ABCA7 \| infer 5243 \| ABCB1 \| infer 8647 \| ABCB11 \| infer 4363 \| ABCC1 \| infer 1244 \| ABCC2 \| infer 10257 \| ABCC4 \| infer 1636 \| ACE \| infer 126 \| ADH1C \| infer 153 \| ADRB1 \| infer 154 \| ADRB2 \| infer 196 \| AHR \| infer 57491 \| AHRR \| infer 10327 \| AKR1A1 \| infer 8644 \| AKR1C3 \| infer 1109 \| AKR1C4 \| infer 207 \| AKT1 \| infer 210 \| ALAD \| infer 10840 \| ALDH1L1 \| infer 217 \| ALDH2 \| infer 239 \| ALOX12 \| infer 246 \| ALOX15 \| infer 240 \| ALOX5 \| infer 23600 \| AMACR \| infer 275 \| AMT \| infer 317 \| APAF1 \| infer 324 \| APC \| infer 328 \| APEX1 \| infer 336 \| APOA2 \| infer 337 \| APOA4 \| infer 338 \| APOB \| infer 348 \| APOE \| infer 397 \| ARHGDIB \| infer 405 \| ARNT \| infer 472 \| ATM \| infer 482 \| ATP1B2 \| infer 6790 \| AURKA \| infer 8313 \| AXIN2 \| infer 578 \| BAK1 \| infer 580 \| BARD1 \| infer 581 \| BAX \| infer 604 \| BCL6 \| infer 613 \| BCR \| infer 635 \| BHMT \| infer 330 \| BIRC3 \| infer 641 \| BLM \| infer 672 \| BRCA1 \| infer 675 \| BRCA2 \| infer 83990 \| BRIP1 \| infer 799 \| CALCR \| infer 843 \| CASP10 \| infer 836 \| CASP3 \| infer 841 \| CASP8 \| infer 842 \| CASP9 \| infer 846 \| CASR \| infer 847 \| CAT \| infer 857 \| CAV1 \| infer 873 \| CBR1 \| infer 874 \| CBR3 \| infer 875 \| CBS \| infer 6352 \| CCL5 \| infer 890 \| CCNA2 \| infer 595 \| CCND1 \| infer 896 \| CCND3 \| infer 902 \| CCNH \| infer 729230 \| CCR2 \| infer 1232 \| CCR3 \| infer 1234 \| CCR5 \| infer 929 \| CD14 \| infer 920 \| CD4 \| infer 958 \| CD40 \| infer 941 \| CD80 \| infer 975 \| CD81 \| infer 942 \| CD86 \| infer 993 \| CDC25A \| infer 994 \| CDC25B \| infer 995 \| CDC25C \| infer 999 \| CDH1 \| infer 1019 \| CDK4 \| infer 1020 \| CDK5 \| infer 1022 \| CDK7 \| infer 1027 \| CDKN1B \| infer 1028 \| CDKN1C \| infer 1029 \| CDKN2A \| infer 1071 \| CETP \| infer 3075 \| CFH \| infer 1080 \| CFTR \| infer 1081 \| CGA \| infer 1111 \| CHEK1 \| infer 1136 \| CHRNA3 \| infer 1137 \| CHRNA4 \| infer 1138 \| CHRNA5 \| infer 80781 \| COL18A1 \| infer 1312 \| COMT \| infer 1401 \| CRP \| infer 1436 \| CSF1R \| infer 1437 \| CSF2 \| infer 1440 \| CSF3 \| infer 1477 \| CSTF1 \| infer 1491 \| CTH \| infer 1493 \| CTLA4 \| infer 1499 \| CTNNB1 \| infer 1512 \| CTSH \| infer 8452 \| CUL3 \| infer 1524 \| CX3CR1 \| infer 1535 \| CYBA \| infer 1536 \| CYBB \| infer 1586 \| CYP17A1 \| infer 1588 \| CYP19A1 \| infer 1543 \| CYP1A1 \| infer 1544 \| CYP1A2 \| infer 1545 \| CYP1B1 \| infer 1591 \| CYP24A1 \| infer 1594 \| CYP27B1 \| infer 1557 \| CYP2C19 \| infer 1565 \| CYP2D6 \| infer 1571 \| CYP2E1 \| infer 1551 \| CYP3A7 \| infer 9420 \| CYP7B1 \| infer 1672 \| DEFB1 \| infer 27294 \| DHDH \| infer 1719 \| DHFR \| infer 1733 \| DIO1 \| infer 202052 \| DNAJC18 \| infer 1812 \| DRD1 \| infer 1813 \| DRD2 \| infer 1815 \| DRD4 \| infer 1906 \| EDN1 \| infer 1950 \| EGF \| infer 1956 \| EGFR \| infer 2022 \| ENG \| infer 2052 \| EPHX1 \| infer 2053 \| EPHX2 \| infer 2064 \| ERBB2 \| infer 2067 \| ERCC1 \| infer 2068 \| ERCC2 \| infer 2071 \| ERCC3 \| infer 2072 \| ERCC4 \| infer 2073 \| ERCC5 \| infer 2074 \| ERCC6 \| infer 2099 \| ESR1 \| infer 2100 \| ESR2 \| infer 9156 \| EXO1 \| infer 7430 \| EZR \| infer 10144 \| FAM13A \| infer 2175 \| FANCA \| infer 355 \| FAS \| infer 356 \| FASLG \| infer 55294 \| FBXW7 \| infer 2335 \| FN1 \| infer 2353 \| FOS \| infer 2296 \| FOXC1 \| infer 2524 \| FUT2 \| infer 8324 \| FZD7 \| infer 2625 \| GATA3 \| infer 2638 \| GC \| infer 9518 \| GDF15 \| infer 8836 \| GGH \| infer 2690 \| GHR \| infer 2876 \| GPX1 \| infer 2877 \| GPX2 \| infer 2878 \| GPX3 \| infer 2879 \| GPX4 \| infer 2932 \| GSK3B \| infer 2941 \| GSTA4 \| infer 2944 \| GSTM1 \| infer 9446 \| GSTO1 \| infer 119391 \| GSTO2 \| infer 2950 \| GSTP1 \| infer 2952 \| GSTT1 \| infer 2954 \| GSTZ1 \| infer 2993 \| GYPA \| infer 3030 \| HADHA \| infer 3077 \| HFE \| infer 64399 \| HHIP \| infer 55662 \| HIF1AN \| infer 3106 \| HLA-B \| infer 3156 \| HMGCR \| infer 3162 \| HMOX1 \| infer 3292 \| HSD17B1 \| infer 3294 \| HSD17B2 \| infer 3295 \| HSD17B4 \| infer 3283 \| HSD3B1 \| infer 3284 \| HSD3B2 \| infer 26353 \| HSPB8 \| infer 3351 \| HTR1B \| infer 3352 \| HTR1D \| infer 3356 \| HTR2A \| infer 3364 \| HUS1 \| infer 3383 \| ICAM1 \| infer 3455 \| IFNAR2 \| infer 3459 \| IFNGR1 \| infer 3460 \| IFNGR2 \| infer 3479 \| IGF1 \| infer 3480 \| IGF1R \| infer 3481 \| IGF2 \| infer 3482 \| IGF2R \| infer 3483 \| IGFALS \| infer 3484 \| IGFBP1 \| infer 3485 \| IGFBP2 \| infer 3486 \| IGFBP3 \| infer 3488 \| IGFBP5 \| infer 3489 \| IGFBP6 \| infer 3586 \| IL10 \| infer 3587 \| IL10RA \| infer 3592 \| IL12A \| infer 3593 \| IL12B \| infer 3596 \| IL13 \| infer 3600 \| IL15 \| infer 3601 \| IL15RA \| infer 3552 \| IL1A \| infer 3553 \| IL1B \| infer 3557 \| IL1RN \| infer 3558 \| IL2 \| infer 3562 \| IL3 \| infer 3565 \| IL4 \| infer 3566 \| IL4R \| infer 3570 \| IL6R \| infer 3575 \| IL7R \| infer 3643 \| INSR \| infer 3658 \| IREB2 \| infer 3659 \| IRF1 \| infer 3661 \| IRF3 \| infer 3667 \| IRS1 \| infer 3718 \| JAK3 \| infer 3845 \| KRAS \| infer 25984 \| KRT23 \| infer 3931 \| LCAT \| infer 3949 \| LDLR \| infer 3952 \| LEP \| infer 3953 \| LEPR \| infer 3978 \| LIG1 \| infer 3980 \| LIG3 \| infer 3990 \| LIPC \| infer 9516 \| LITAF \| infer 4005 \| LMO2 \| infer 25802 \| LMOD1 \| infer 4023 \| LPL \| infer 4041 \| LRP5 \| infer 4040 \| LRP6 \| infer 4049 \| LTA \| infer 5648 \| MASP1 \| infer 9782 \| MATR3 \| infer 8932 \| MBD2 \| infer 8930 \| MBD4 \| infer 4153 \| MBL2 \| infer 4193 \| MDM2 \| infer 4232 \| MEST \| infer 4233 \| MET \| infer 4255 \| MGMT \| infer 114614 \| MIR155HG \| infer 4292 \| MLH1 \| infer 4312 \| MMP1 \| infer 4321 \| MMP12 \| infer 4313 \| MMP2 \| infer 4318 \| MMP9 \| infer 9526 \| MPDU1 \| infer 4353 \| MPO \| infer 55686 \| MREG \| infer 4436 \| MSH2 \| infer 4437 \| MSH3 \| infer 2956 \| MSH6 \| infer 4481 \| MSR1 \| infer 10797 \| MTHFD2 \| infer 4524 \| MTHFR \| infer 4548 \| MTR \| infer 4552 \| MTRR \| infer 4599 \| MX1 \| infer 4605 \| MYBL2 \| infer 4609 \| MYC \| infer 55892 \| MYNN \| infer 4644 \| MYO5A \| infer 4683 \| NBN \| infer 4688 \| NCF2 \| infer 8202 \| NCOA3 \| infer 4790 \| NFKB1 \| infer 4794 \| NFKBIE \| infer 4814 \| NINJ1 \| infer 64127 \| NOD2 \| infer 4843 \| NOS2 \| infer 4846 \| NOS3 \| infer 1728 \| NQO1 \| infer 9971 \| NR1H4 \| infer 4682 \| NUBP1 \| infer 10101 \| NUBP2 \| infer 4948 \| OCA2 \| infer 4968 \| OGG1 \| infer 4985 \| OPRD1 \| infer 4988 \| OPRM1 \| infer 5027 \| P2RX7 \| infer 56924 \| PAK6 \| infer 142 \| PARP1 \| infer 143 \| PARP4 \| infer 5111 \| PCNA \| infer 58488 \| PCTP \| infer 55825 \| PECR \| infer 5241 \| PGR \| infer 5245 \| PHB \| infer 5292 \| PIM1 \| infer 5300 \| PIN1 \| infer 5320 \| PLA2G2A \| infer 8398 \| PLA2G6 \| infer 5347 \| PLK1 \| infer 5378 \| PMS1 \| infer 5395 \| PMS2 \| infer 5423 \| POLB \| infer 5424 \| POLD1 \| infer 25913 \| POT1 \| infer 5468 \| PPARG \| infer 5685 \| PSMA4 \| infer 5728 \| PTEN \| infer 5742 \| PTGS1 \| infer 5743 \| PTGS2 \| infer 5741 \| PTH \| infer 376267 \| RAB15 \| infer 5879 \| RAC1 \| infer 5887 \| RAD23B \| infer 5888 \| RAD51 \| infer 5893 \| RAD52 \| infer 8438 \| RAD54L \| infer 5896 \| RAG1 \| infer 9821 \| RB1CC1 \| infer 85004 \| RERG \| infer 5979 \| RET \| infer 26575 \| RGS17 \| infer 8490 \| RGS5 \| infer 9628 \| RGS6 \| infer 6041 \| RNASEL \| infer 6098 \| ROS1 \| infer 6256 \| RXRA \| infer 6257 \| RXRB \| infer 112483 \| SAT2 \| infer 949 \| SCARB1 \| infer 57758 \| SCUBE2 \| infer 23541 \| SEC14L2 \| infer 5265 \| SERPINA1 \| infer 12 \| SERPINA3 \| infer 5270 \| SERPINE2 \| infer 6441 \| SFTPD \| infer 6462 \| SHBG \| infer 6504 \| SLAMF1 \| infer 6573 \| SLC19A1 \| infer 9963 \| SLC23A1 \| infer 9962 \| SLC23A2 \| infer 6513 \| SLC2A1 \| infer 6517 \| SLC2A4 \| infer 7779 \| SLC30A1 \| infer 7782 \| SLC30A4 \| infer 29986 \| SLC39A2 \| infer 6522 \| SLC4A2 \| infer 6531 \| SLC6A3 \| infer 6532 \| SLC6A4 \| infer 8435 \| SOAT2 \| infer 6647 \| SOD1 \| infer 6648 \| SOD2 \| infer 6649 \| SOD3 \| infer 79582 \| SPAG16 \| infer 10011 \| SRA1 \| infer 6753 \| SSTR3 \| infer 6772 \| STAT1 \| infer 6794 \| STK11 \| infer 7011 \| TEP1 \| infer 7013 \| TERF1 \| infer 7014 \| TERF2 \| infer 7015 \| TERT \| infer 7031 \| TFF1 \| infer 7033 \| TFF3 \| infer 7037 \| TFRC \| infer 7040 \| TGFB1 \| infer 7046 \| TGFBR1 \| infer 7051 \| TGM1 \| infer 7077 \| TIMP2 \| infer 7097 \| TLR2 \| infer 7099 \| TLR4 \| infer 92691 \| TMEM169 \| infer 7124 \| TNF \| infer 8797 \| TNFRSF10A \| infer 7132 \| TNFRSF1A \| infer 10318 \| TNIP1 \| infer 8658 \| TNKS \| infer 7157 \| TP53 \| infer 9540 \| TP53I3 \| infer 8626 \| TP63 \| infer 7251 \| TSG101 \| infer 222642 \| TSPO2 \| infer 7298 \| TYMS \| infer 7299 \| TYR \| infer 7352 \| UCP3 \| infer 54657 \| UGT1A4 \| infer 7412 \| VCAM1 \| infer 7421 \| VDR \| infer 7422 \| VEGFA \| infer 55135 \| WRAP53 \| infer 7486 \| WRN \| infer 7494 \| XBP1 \| infer 7508 \| XPC \| infer 7515 \| XRCC1 \| infer 7517 \| XRCC3 \| infer 7518 \| XRCC4 \| infer 7520 \| XRCC5 \| infer 161882 \| ZFPM1 \| infer 7773 \| ZNF230 \| infer 59348 \| ZNF350 \| infer 80332 \| ADAM33 \| infer 177 \| AGER \| infer 308 \| ANXA5 \| infer 362 \| AQP5 \| infer 624 \| BDKRB2 \| infer 6347 \| CCL2 \| infer 990 \| CDC6 \| infer 9425 \| CDYL \| infer 1285 \| COL4A3 \| infer 1394 \| CRHR1 \| infer 1572 \| CYP2F1 \| infer 1577 \| CYP3A5 \| infer 201163 \| FLCN \| infer 2729 \| GCLC \| infer 2730 \| GCLM \| infer 79807 \| GSTCD \| infer 3360 \| HTR4 \| infer 246778 \| IL27 \| infer 3569 \| IL6 \| infer 100130549 \| ISCA1P6 \| infer 9817 \| KEAP1 \| infer 391703 \| KRT18P51 \| infer 7804 \| LRP8 \| infer 4314 \| MMP3 \| infer 10 \| NAT2 \| infer 4780 \| NFE2L2 \| infer 2908 \| NR3C1 \| infer 51196 \| PLCE1 \| infer 53916 \| RAB4B \| infer 6439 \| SFTPB \| infer 6556 \| SLC11A1 \| infer 4088 \| SMAD3 \| infer 9655 \| SOCS5 \| infer 79875 \| THSD4 \| infer 7145 \| TNS1 \| infer 59341 \| TRPV4 \| infer 221504 \| ZBTB9 \| infer
Text Mined Gene	(Waiting for update.)
Locus	(Waiting for update.)

Disease ID	1888
Disease	pulmonary disease, chronic obstructive
Integrated Phenotype	(Waiting for update.)
Text Mined Phenotype	(Waiting for update.)

Disease ID	1888
Disease	pulmonary disease, chronic obstructive
Manually Symptom	(Waiting for update.)
Text Mined Symptom	(Waiting for update.)

Manually Genotype(Total Text Mining Genotypes:0)
(Waiting for update.)

All Snps(Total Genotypes:186)
snpId	pubmedId	geneId	geneSymbol	diseaseId	sourceId	sentence	score	Year	geneSymbol_dbSNP	CHROMOSOME	POS	REF	ALT
rs10007052	23144326	57484	RNF150	umls:C0024117	GWASCAT	Genome-wide association analysis of blood biomarkers in chronic obstructive pulmonary disease.	0.120271442	2012	RNF150	4	141084419	C	A
rs1042713	22075484	154	ADRB2	umls:C0024117	BeFree	We tested the hypothesis that three functional polymorphisms in the ADRB2 gene (Thr164Ile, Gly16Arg and Gln27Glu) are associated with reduced lung function, asthma or chronic obstructive pulmonary disease (COPD).	0.041820706	2012	ADRB2	5	148826877	G	A
rs1042713	19747908	154	ADRB2	umls:C0024117	BeFree	The SERPINA1 p.V213A polymorphism was found associated with DB risk while the ADRB2 p.G16R is a risk factor for severe COPD in smokers.	0.041820706	2010	ADRB2	5	148826877	G	A
rs1042713	25186548	154	ADRB2	umls:C0024117	BeFree	Finally, we found that the rare Thr164Ile polymorphism in ADRB2 was associated with reduced lung function and risk of COPD, whereas the more common Gly16Arg and Gln27Glu were not.	0.041820706	2015	ADRB2	5	148826877	G	A
rs1042713	19747908	5265	SERPINA1	umls:C0024117	BeFree	The SERPINA1 p.V213A polymorphism was found associated with DB risk while the ADRB2 p.G16R is a risk factor for severe COPD in smokers.	0.178707522	2010	ADRB2	5	148826877	G	A
rs1042714	25186548	154	ADRB2	umls:C0024117	BeFree	Finally, we found that the rare Thr164Ile polymorphism in ADRB2 was associated with reduced lung function and risk of COPD, whereas the more common Gly16Arg and Gln27Glu were not.	0.041820706	2015	ADRB2	5	148826910	G	C,T
rs1042714	22075484	154	ADRB2	umls:C0024117	BeFree	We tested the hypothesis that three functional polymorphisms in the ADRB2 gene (Thr164Ile, Gly16Arg and Gln27Glu) are associated with reduced lung function, asthma or chronic obstructive pulmonary disease (COPD).	0.041820706	2012	ADRB2	5	148826910	G	C,T
rs1051730	22441734	1136	CHRNA3	umls:C0024117	BeFree	In ever-smokers, the CHRNA3 rs1051730 genotype associated with reduced lung function and increased COPD severity.	0.129077134	2012	CHRNA3	15	78601997	G	A
rs1051730	22176972	1134	CHRNA1	umls:C0024117	BeFree	Our findings suggest that rs1051730 in CHRNA is a susceptibility variant for COPD, in terms of both airway obstruction and parenchyma destruction.	0.000542884	2011	CHRNA3	15	78601997	G	A
rs1052133	19493423	4968	OGG1	umls:C0024117	BeFree	hOGG1 Ser326Cys and XRCC1 Arg399Gln polymorphisms associated with chronic obstructive pulmonary disease.	0.005276948	2009	OGG1;CAMK1	3	9757089	C	G
rs1052133	19493423	7515	XRCC1	umls:C0024117	BeFree	hOGG1 Ser326Cys and XRCC1 Arg399Gln polymorphisms associated with chronic obstructive pulmonary disease.	0.00764398	2009	OGG1;CAMK1	3	9757089	C	G
rs11134242	22461431	79875	THSD4	umls:C0024117	BeFree	We included three SNPs previously associated with COPD: rs7671167 (FAM13A), rs13180 (IREB2), and rs8034191 (CHRNA 3/5), and four SNPs associated with lung function in a genome-wide association study of general population samples: rs2070600 (AGER), rs11134242 (ADCY2), rs4316710 (THSD4), and rs17096090 (INTS12).	0.003181358	2012	ADCY2	5	7563902	G	T
rs11134242	22461431	57117	INTS12	umls:C0024117	BeFree	We included three SNPs previously associated with COPD: rs7671167 (FAM13A), rs13180 (IREB2), and rs8034191 (CHRNA 3/5), and four SNPs associated with lung function in a genome-wide association study of general population samples: rs2070600 (AGER), rs11134242 (ADCY2), rs4316710 (THSD4), and rs17096090 (INTS12).	0.000542884	2012	ADCY2	5	7563902	G	T
rs11134242	22461431	10144	FAM13A	umls:C0024117	BeFree	We included three SNPs previously associated with COPD: rs7671167 (FAM13A), rs13180 (IREB2), and rs8034191 (CHRNA 3/5), and four SNPs associated with lung function in a genome-wide association study of general population samples: rs2070600 (AGER), rs11134242 (ADCY2), rs4316710 (THSD4), and rs17096090 (INTS12).	0.247991366	2012	ADCY2	5	7563902	G	T
rs11174267	24621683	338811	FAM19A2	umls:C0024117	GWASCAT	Risk loci for chronic obstructive pulmonary disease: a genome-wide association study and meta-analysis.	0.12	2014	FAM19A2	12	61992819	A	C,G
rs1130866	15817713	3162	HMOX1	umls:C0024117	BeFree	In the Boston Early-Onset COPD Study families, significant associations with quantitative and/or qualitative COPD-related phenotypes were found for the tumor necrosis factor (TNF)-alpha -308G>A promoter polymorphism (P < 0.02), a coding variant in surfactant protein B (SFTPB Thr131Ile) (P = 0.03), and the (GT)(31) allele of the heme oxygenase (HMOX1) promoter short tandem repeat (P = 0.02).	0.136645169	2005	SFTPB	2	85666618	G	A
rs1130866	15817713	6439	SFTPB	umls:C0024117	BeFree	In the case-control study, the SFTPB Thr131Ile polymorphism was associated with COPD, but only in the presence of a gene-by-environment interaction term (P = 0.01 for both main effect and interaction).	0.026742057	2005	SFTPB	2	85666618	G	A
rs1130866	15817713	7124	TNF	umls:C0024117	BeFree	In the Boston Early-Onset COPD Study families, significant associations with quantitative and/or qualitative COPD-related phenotypes were found for the tumor necrosis factor (TNF)-alpha -308G>A promoter polymorphism (P < 0.02), a coding variant in surfactant protein B (SFTPB Thr131Ile) (P = 0.03), and the (GT)(31) allele of the heme oxygenase (HMOX1) promoter short tandem repeat (P = 0.02).	0.184914467	2005	SFTPB	2	85666618	G	A
rs1130866	25299874	54738	FEV	umls:C0024117	BeFree	The SFTPB exon polymorphism rs1130866 significantly protected subjects from COPD (adjusted P = 0.004) and was associated with an increase in forced expiratory volume in 1 s (FEV(1)) (adjusted P = 0.014).	0.007871814	2015	SFTPB	2	85666618	G	A
rs114216682	21685187	7804	LRP8	umls:C0024117	GAD	[The authors identified two candidate regions associated with age at smoking initiation in patients with COPD.]	0.002367032	2011	NA	1	53405413	G	C
rs117607728	21685187	51196	PLCE1	umls:C0024117	GAD	[The authors identified two candidate regions associated with age at smoking initiation in patients with COPD.]	0.002367032	2011	PLCE1	10	94298879	G	T
rs11779254	24876173	6660	SOX5	umls:C0024117	BeFree	The non-Hispanic white GWAS identified single nucleotide polymorphisms in the genes CSMD1 (rs11779254, p=1.57 × 10(-6)) and SOX5 (rs59569785, p=1.61 × 10(-6)) and the meta-analysis identified single nucleotide polymorphisms in the gene GPR65 (rs6574978, p=1.18 × 10(-7)) associated with COPD and asthma overlap.	0.000542884	2015	CSMD1	8	4391552	G	C
rs11779254	24876173	8477	GPR65	umls:C0024117	BeFree	The non-Hispanic white GWAS identified single nucleotide polymorphisms in the genes CSMD1 (rs11779254, p=1.57 × 10(-6)) and SOX5 (rs59569785, p=1.61 × 10(-6)) and the meta-analysis identified single nucleotide polymorphisms in the gene GPR65 (rs6574978, p=1.18 × 10(-7)) associated with COPD and asthma overlap.	0.000271442	2015	CSMD1	8	4391552	G	C
rs11779254	24876173	64478	CSMD1	umls:C0024117	BeFree	The non-Hispanic white GWAS identified single nucleotide polymorphisms in the genes CSMD1 (rs11779254, p=1.57 × 10(-6)) and SOX5 (rs59569785, p=1.61 × 10(-6)) and the meta-analysis identified single nucleotide polymorphisms in the gene GPR65 (rs6574978, p=1.18 × 10(-7)) associated with COPD and asthma overlap.	0.120271442	2015	CSMD1	8	4391552	G	C
rs11858836	22080838	3658	IREB2	umls:C0024117	GAD	[To date, genome-wide association studies (GWASs) of limited size have identified several novel risk loci for COPD at CHRNA3/CHRNA5/IREB2, HHIP and FAM13A; additional loci may be identified through larger studies.]	0.129272631	2012	IREB2	15	78490935	G	A
rs11858836	22080838	3658	IREB2	umls:C0024117	GWASCAT	To date, genome-wide association studies (GWASs) of limited size have identified several novel risk loci for COPD at CHRNA3/CHRNA5/IREB2, HHIP and FAM13A; additional loci may be identified through larger studies.	0.129272631	2012	IREB2	15	78490935	G	A
rs1205	23267696	140913	PPIAP10	umls:C0024117	BeFree	Haplotype analysis showed that the frequencies of the GC, GT haplotypes of rs2241718 (TGF-β1 gene), and rs6957 (CDC97 gene) were significantly higher in the control group than in the COPD case group (p=1.88×10-9); the frequencies of the TT haplotype of rs1205 and rs2808630 (CRP gene) were significantly higher in the control group (p=0.0377).	0.000271442	2012	CRP	1	159712443	C	T
rs1205	23267696	7040	TGFB1	umls:C0024117	BeFree	Haplotype analysis showed that the frequencies of the GC, GT haplotypes of rs2241718 (TGF-β1 gene), and rs6957 (CDC97 gene) were significantly higher in the control group than in the COPD case group (p=1.88×10-9); the frequencies of the TT haplotype of rs1205 and rs2808630 (CRP gene) were significantly higher in the control group (p=0.0377).	0.243744544	2012	CRP	1	159712443	C	T
rs121917864	19381722	7097	TLR2	umls:C0024117	BeFree	Toll-like receptor 2 gene polymorphisms Arg677Trp and Arg753Gln in chronic obstructive pulmonary disease.	0.013364122	2009	TLR2	4	153704936	C	T
rs1265093	23144326	170680	PSORS1C2	umls:C0024117	GWASCAT	Genome-wide association analysis of blood biomarkers in chronic obstructive pulmonary disease.	0.12	2012	PSORS1C1;PSORS1C2	6	31139410	G	A
rs1265093	23144326	170679	PSORS1C1	umls:C0024117	GWASCAT	Genome-wide association analysis of blood biomarkers in chronic obstructive pulmonary disease.	0.12	2012	PSORS1C1;PSORS1C2	6	31139410	G	A
rs12692398	25241909	192668	CYS1	umls:C0024117	GWASCAT	Genetic susceptibility for chronic bronchitis in chronic obstructive pulmonary disease.	0.12	2014	CYS1	2	10060189	G	A
rs12914385	25101718	1136	CHRNA3	umls:C0024117	GWASCAT	IREB2 and GALC are associated with pulmonary artery enlargement in chronic obstructive pulmonary disease.	0.129077134	2015	CHRNA3	15	78606381	C	T
rs12914385	24621683	1136	CHRNA3	umls:C0024117	GWASCAT	Analysis of 6633 individuals with moderate to severe COPD and 5704 control individuals confirmed association at three known loci: CHRNA3 (p=6·38 × 10(-14)), FAM13A (p=1·12 × 10(-14)), and HHIP (p=1·57 × 10(-12)).	0.129077134	2014	CHRNA3	15	78606381	C	T
rs12914385	25241909	1136	CHRNA3	umls:C0024117	GWASCAT	Genetic susceptibility for chronic bronchitis in chronic obstructive pulmonary disease.	0.129077134	2014	CHRNA3	15	78606381	C	T
rs13010343	20562129	4793	NFKBIB	umls:C0024117	BeFree	Significant associations to the binary COPD phenotype in both populations were seen for STAT1 (rs13010343) and NFKBIB/SIRT2 (rs2241704) (p<0.05).	0.000271442	2011	STAT1	2	190978719	G	A
rs13010343	20562129	22933	SIRT2	umls:C0024117	BeFree	Significant associations to the binary COPD phenotype in both populations were seen for STAT1 (rs13010343) and NFKBIB/SIRT2 (rs2241704) (p<0.05).	0.000271442	2011	STAT1	2	190978719	G	A
rs13118928	20173748	64399	HHIP	umls:C0024117	GAD	[Variants in FAM13A are associated with chronic obstructive pulmonary disease.]	0.01272543	2010	NA	4	144565237	A	G
rs13118928	20173748	2993	GYPA	umls:C0024117	GAD	[Variants in FAM13A are associated with chronic obstructive pulmonary disease.]	0.007101096	2010	NA	4	144565237	A	G
rs13118928	19996190	64399	HHIP	umls:C0024117	BeFree	A genome-wide association study has demonstrated that two single nucleotide polymorphisms (SNPs) near the Hedgehog-interacting protein (Hip) gene, SNP identifiers rs1828591 and rs13118928, are associated with risk of chronic obstructive pulmonary disease (COPD).	0.01272543	2010	NA	4	144565237	A	G
rs13180	20173748	1136	CHRNA3	umls:C0024117	GAD	[Variants in FAM13A are associated with chronic obstructive pulmonary disease.]	0.129077134	2010	IREB2	15	78497146	C	T
rs13180	20173748	1138	CHRNA5	umls:C0024117	GAD	[Variants in FAM13A are associated with chronic obstructive pulmonary disease.]	0.127177041	2010	IREB2	15	78497146	C	T
rs13180	20173748	3658	IREB2	umls:C0024117	GWASCAT	Variants in FAM13A are associated with chronic obstructive pulmonary disease.	0.129272631	2010	IREB2	15	78497146	C	T
rs13180	25565795	3658	IREB2	umls:C0024117	BeFree	Our results support that IREB2 rs13180 is associated with COPD in Hainan population.	0.129272631	2015	IREB2	15	78497146	C	T
rs13180	22461431	10144	FAM13A	umls:C0024117	BeFree	We included three SNPs previously associated with COPD: rs7671167 (FAM13A), rs13180 (IREB2), and rs8034191 (CHRNA 3/5), and four SNPs associated with lung function in a genome-wide association study of general population samples: rs2070600 (AGER), rs11134242 (ADCY2), rs4316710 (THSD4), and rs17096090 (INTS12).	0.247991366	2012	IREB2	15	78497146	C	T
rs13180	22461431	57117	INTS12	umls:C0024117	BeFree	We included three SNPs previously associated with COPD: rs7671167 (FAM13A), rs13180 (IREB2), and rs8034191 (CHRNA 3/5), and four SNPs associated with lung function in a genome-wide association study of general population samples: rs2070600 (AGER), rs11134242 (ADCY2), rs4316710 (THSD4), and rs17096090 (INTS12).	0.000542884	2012	IREB2	15	78497146	C	T
rs13180	22461431	79875	THSD4	umls:C0024117	BeFree	We included three SNPs previously associated with COPD: rs7671167 (FAM13A), rs13180 (IREB2), and rs8034191 (CHRNA 3/5), and four SNPs associated with lung function in a genome-wide association study of general population samples: rs2070600 (AGER), rs11134242 (ADCY2), rs4316710 (THSD4), and rs17096090 (INTS12).	0.003181358	2012	IREB2	15	78497146	C	T
rs13180	20173748	3658	IREB2	umls:C0024117	GAD	[Variants in FAM13A are associated with chronic obstructive pulmonary disease.]	0.129272631	2010	IREB2	15	78497146	C	T
rs139257032	25241909	200373	CFAP221	umls:C0024117	GWASCAT	Genetic susceptibility for chronic bronchitis in chronic obstructive pulmonary disease.	0.12	2014	CFAP221	2	119571288	C	T
rs142700918	25241909	64478	CSMD1	umls:C0024117	GWASCAT	Genetic susceptibility for chronic bronchitis in chronic obstructive pulmonary disease.	0.120271442	2014	CSMD1	8	3448320	G	A
rs151129007	22094117	4314	MMP3	umls:C0024117	BeFree	In a multivariable logistic regression analysis adjusted for traditional cardiovascular risk factors and chronic obstructive pulmonary disease, -1306C/T MMP2 (odds ratios [OR] = 0.55 [95% confidence interval, CI .34-.85], P < .007) and G1355A ELN (OR = 0.64 ([95% CI .41-.99], P = .046) polymorphisms resulted in independent protective factors for abdominal aortic aneurysm (AAA), whereas 5A/6A MMP3 (OR = 1.82 [95% CI 1.04-3.12], P = .034) and -77 A/G MMP-13 (OR = 2.14 [95% CI 1.18-3.86], P = .012) polymorphisms resulted in independent risk factors for AAA.	0.007915422	2012	MMP2	16	55481799	A	G
rs151129007	22094117	4322	MMP13	umls:C0024117	BeFree	In a multivariable logistic regression analysis adjusted for traditional cardiovascular risk factors and chronic obstructive pulmonary disease, -1306C/T MMP2 (odds ratios [OR] = 0.55 [95% confidence interval, CI .34-.85], P < .007) and G1355A ELN (OR = 0.64 ([95% CI .41-.99], P = .046) polymorphisms resulted in independent protective factors for abdominal aortic aneurysm (AAA), whereas 5A/6A MMP3 (OR = 1.82 [95% CI 1.04-3.12], P = .034) and -77 A/G MMP-13 (OR = 2.14 [95% CI 1.18-3.86], P = .012) polymorphisms resulted in independent risk factors for AAA.	0.000271442	2012	MMP2	16	55481799	A	G
rs151129007	22094117	2006	ELN	umls:C0024117	BeFree	In a multivariable logistic regression analysis adjusted for traditional cardiovascular risk factors and chronic obstructive pulmonary disease, -1306C/T MMP2 (odds ratios [OR] = 0.55 [95% confidence interval, CI .34-.85], P < .007) and G1355A ELN (OR = 0.64 ([95% CI .41-.99], P = .046) polymorphisms resulted in independent protective factors for abdominal aortic aneurysm (AAA), whereas 5A/6A MMP3 (OR = 1.82 [95% CI 1.04-3.12], P = .034) and -77 A/G MMP-13 (OR = 2.14 [95% CI 1.18-3.86], P = .012) polymorphisms resulted in independent risk factors for AAA.	0.007262917	2012	MMP2	16	55481799	A	G
rs1542725	22140090	6670	SP3	umls:C0024117	BeFree	Moreover, rs1542725 demonstrates differential binding to the transcription factor Sp3; the COPD-associated allele exhibits increased Sp3 binding, which is consistent with Sp3's usual function as a transcriptional repressor.	0.000271442	2012	NA	4	144567182	C	T
rs16944	24504887	3557	IL1RN	umls:C0024117	BeFree	Genetic polymorphisms of surfactant protein D rs2243639, Interleukin (IL)-1β rs16944 and IL-1RN rs2234663 in chronic obstructive pulmonary disease, healthy smokers, and non-smokers.	0.013821129	2015	IL1B	2	112837290	A	G
rs16944	24504887	3553	IL1B	umls:C0024117	BeFree	The primary aim of this study was to investigate the association between surfactant protein D (SFTPD) rs2243639, interleukin (IL)-1β rs16944 and IL-1 receptor antagonist (IL-1RN) rs2234663 gene polymorphisms and COPD susceptibility, as well as examining the association between the various IL-1RN/IL-1β haplotypes and pulmonary function tests (PFT).	0.021279544	2015	IL1B	2	112837290	A	G
rs1695	19608716	2950	GSTP1	umls:C0024117	BeFree	The GSTP1 I105V polymorphism was protective for COPD in Asian populations only (OR, 0.69; 95% CI, 0.56-0.85).	0.042397266	2009	GSTP1	11	67585218	A	G
rs17096090	22461431	10144	FAM13A	umls:C0024117	BeFree	We included three SNPs previously associated with COPD: rs7671167 (FAM13A), rs13180 (IREB2), and rs8034191 (CHRNA 3/5), and four SNPs associated with lung function in a genome-wide association study of general population samples: rs2070600 (AGER), rs11134242 (ADCY2), rs4316710 (THSD4), and rs17096090 (INTS12).	0.247991366	2012	NA	NA	NA	NA	NA
rs17096090	22461431	57117	INTS12	umls:C0024117	BeFree	We included three SNPs previously associated with COPD: rs7671167 (FAM13A), rs13180 (IREB2), and rs8034191 (CHRNA 3/5), and four SNPs associated with lung function in a genome-wide association study of general population samples: rs2070600 (AGER), rs11134242 (ADCY2), rs4316710 (THSD4), and rs17096090 (INTS12).	0.000542884	2012	NA	NA	NA	NA	NA
rs17096090	22461431	79875	THSD4	umls:C0024117	BeFree	We included three SNPs previously associated with COPD: rs7671167 (FAM13A), rs13180 (IREB2), and rs8034191 (CHRNA 3/5), and four SNPs associated with lung function in a genome-wide association study of general population samples: rs2070600 (AGER), rs11134242 (ADCY2), rs4316710 (THSD4), and rs17096090 (INTS12).	0.003181358	2012	NA	NA	NA	NA	NA
rs17486278	25101718	1138	CHRNA5	umls:C0024117	GWASCAT	IREB2 and GALC are associated with pulmonary artery enlargement in chronic obstructive pulmonary disease.	0.127177041	2015	CHRNA5	15	78575140	A	C
rs1799782	19821085	7515	XRCC1	umls:C0024117	BeFree	XRCC1 Arg194Trp polymorphism and risk of chronic obstructive pulmonary disease.	0.00764398	2009	XRCC1	19	43553422	G	A
rs1799864	22276574	729230	CCR2	umls:C0024117	BeFree	These data suggest that MCP-1 -2518 A/G and CCR2 190G/A polymorphisms are new risk factors for COPD.	0.002638474	2012	CCR2	3	46357717	G	A
rs1800076	15463907	1080	CFTR	umls:C0024117	BeFree	High frequency of the R75Q CFTR variation in patients with chronic obstructive pulmonary disease.	0.019640961	2004	CFTR	7	117509093	G	A,T
rs1800888	25186548	154	ADRB2	umls:C0024117	BeFree	Finally, we found that the rare Thr164Ile polymorphism in ADRB2 was associated with reduced lung function and risk of COPD, whereas the more common Gly16Arg and Gln27Glu were not.	0.041820706	2015	ADRB2	5	148827322	C	T
rs1800888	22075484	154	ADRB2	umls:C0024117	BeFree	We tested the hypothesis that three functional polymorphisms in the ADRB2 gene (Thr164Ile, Gly16Arg and Gln27Glu) are associated with reduced lung function, asthma or chronic obstructive pulmonary disease (COPD).	0.041820706	2012	ADRB2	5	148827322	C	T
rs1828591	19996190	64399	HHIP	umls:C0024117	BeFree	A genome-wide association study has demonstrated that two single nucleotide polymorphisms (SNPs) near the Hedgehog-interacting protein (Hip) gene, SNP identifiers rs1828591 and rs13118928, are associated with risk of chronic obstructive pulmonary disease (COPD).	0.01272543	2010	LOC105377462	4	144559628	A	G
rs1828591	19300482	2993	GYPA	umls:C0024117	GAD	[A genome-wide association study in chronic obstructive pulmonary disease (COPD): identification of two major susceptibility loci.]	0.007101096	2009	LOC105377462	4	144559628	A	G
rs1828591	19300482	64399	HHIP	umls:C0024117	GAD	[The CHRNA 3/5 and the HHIP loci make a significant contribution to the risk of COPD.]	0.01272543	2009	LOC105377462	4	144559628	A	G
rs1883832	19622350	958	CD40	umls:C0024117	BeFree	Association of CD40 -1C/T polymorphism in the 5'-untranslated region and chronic obstructive pulmonary disease.	0.007915422	2009	CD40	20	46118343	T	C
rs1964516	22080838	10144	FAM13A	umls:C0024117	GAD	[To date, genome-wide association studies (GWASs) of limited size have identified several novel risk loci for COPD at CHRNA3/CHRNA5/IREB2, HHIP and FAM13A; additional loci may be identified through larger studies.]	0.247991366	2012	FAM13A;LOC105377327	4	88954758	C	T
rs1964516	22080838	10144	FAM13A	umls:C0024117	GWASCAT	To date, genome-wide association studies (GWASs) of limited size have identified several novel risk loci for COPD at CHRNA3/CHRNA5/IREB2, HHIP and FAM13A; additional loci may be identified through larger studies.	0.247991366	2012	FAM13A;LOC105377327	4	88954758	C	T
rs2069825	21814463	3569	IL6	umls:C0024117	BeFree	The IL6 rs2069825 single nucleotide polymorphism also interacted with smoking to affect the risk of cardiovascular disease in COPD patients.	0.029466407	2011	IL6;LOC541472	7	22725718	-	CT,TC
rs2070600	22461431	10144	FAM13A	umls:C0024117	BeFree	We included three SNPs previously associated with COPD: rs7671167 (FAM13A), rs13180 (IREB2), and rs8034191 (CHRNA 3/5), and four SNPs associated with lung function in a genome-wide association study of general population samples: rs2070600 (AGER), rs11134242 (ADCY2), rs4316710 (THSD4), and rs17096090 (INTS12).	0.247991366	2012	AGER	6	32183666	C	T
rs2070600	22461431	79875	THSD4	umls:C0024117	BeFree	We included three SNPs previously associated with COPD: rs7671167 (FAM13A), rs13180 (IREB2), and rs8034191 (CHRNA 3/5), and four SNPs associated with lung function in a genome-wide association study of general population samples: rs2070600 (AGER), rs11134242 (ADCY2), rs4316710 (THSD4), and rs17096090 (INTS12).	0.003181358	2012	AGER	6	32183666	C	T
rs2070600	22461431	57117	INTS12	umls:C0024117	BeFree	We included three SNPs previously associated with COPD: rs7671167 (FAM13A), rs13180 (IREB2), and rs8034191 (CHRNA 3/5), and four SNPs associated with lung function in a genome-wide association study of general population samples: rs2070600 (AGER), rs11134242 (ADCY2), rs4316710 (THSD4), and rs17096090 (INTS12).	0.000542884	2012	AGER	6	32183666	C	T
rs2074488	23144326	3107	HLA-C	umls:C0024117	GWASCAT	Genome-wide association analysis of blood biomarkers in chronic obstructive pulmonary disease.	0.12	2012	HLA-C;LOC101929772	6	31272654	G	T
rs2227744	24973402	2149	F2R	umls:C0024117	BeFree	The aim of this study was to investigate the role of the promoter single-nucleotide polymorphism (SNP) rs2227744G>A in modulating PAR-1/F2R gene expression in the context of chronic obstructive pulmonary disease (COPD) and COPD exacerbations.	0.000542884	2014	F2R	5	76714524	G	A
rs2234663	24504887	3553	IL1B	umls:C0024117	BeFree	The primary aim of this study was to investigate the association between surfactant protein D (SFTPD) rs2243639, interleukin (IL)-1β rs16944 and IL-1 receptor antagonist (IL-1RN) rs2234663 gene polymorphisms and COPD susceptibility, as well as examining the association between the various IL-1RN/IL-1β haplotypes and pulmonary function tests (PFT).	0.021279544	2015	NA	NA	NA	NA	NA
rs2234663	24504887	3557	IL1RN	umls:C0024117	BeFree	Genetic polymorphisms of surfactant protein D rs2243639, Interleukin (IL)-1β rs16944 and IL-1RN rs2234663 in chronic obstructive pulmonary disease, healthy smokers, and non-smokers.	0.013821129	2015	NA	NA	NA	NA	NA
rs2234922	17363767	2052	EPHX1	umls:C0024117	BeFree	In a case-control analysis of COPD susceptibility limited to cases with densitometric upper-lobe-predominant cases, the EPHX1 His139Arg single-nucleotide polymorphism was associated with COPD (p = 0.005).	0.169736128	2007	EPHX1	1	225838705	A	G,T
rs2241704	20562129	22933	SIRT2	umls:C0024117	BeFree	Significant associations to the binary COPD phenotype in both populations were seen for STAT1 (rs13010343) and NFKBIB/SIRT2 (rs2241704) (p<0.05).	0.000271442	2011	NFKBIB	19	38905695	A	T
rs2241704	20562129	4793	NFKBIB	umls:C0024117	BeFree	Significant associations to the binary COPD phenotype in both populations were seen for STAT1 (rs13010343) and NFKBIB/SIRT2 (rs2241704) (p<0.05).	0.000271442	2011	NFKBIB	19	38905695	A	T
rs2241718	23267696	7040	TGFB1	umls:C0024117	BeFree	Haplotype analysis showed that the frequencies of the GC, GT haplotypes of rs2241718 (TGF-β1 gene), and rs6957 (CDC97 gene) were significantly higher in the control group than in the COPD case group (p=1.88×10-9); the frequencies of the TT haplotype of rs1205 and rs2808630 (CRP gene) were significantly higher in the control group (p=0.0377).	0.243744544	2012	CCDC97	19	41323701	G	A
rs2241718	23267696	140913	PPIAP10	umls:C0024117	BeFree	Haplotype analysis showed that the frequencies of the GC, GT haplotypes of rs2241718 (TGF-β1 gene), and rs6957 (CDC97 gene) were significantly higher in the control group than in the COPD case group (p=1.88×10-9); the frequencies of the TT haplotype of rs1205 and rs2808630 (CRP gene) were significantly higher in the control group (p=0.0377).	0.000271442	2012	CCDC97	19	41323701	G	A
rs2243639	24504887	3557	IL1RN	umls:C0024117	BeFree	Genetic polymorphisms of surfactant protein D rs2243639, Interleukin (IL)-1β rs16944 and IL-1RN rs2234663 in chronic obstructive pulmonary disease, healthy smokers, and non-smokers.	0.013821129	2015	SFTPD	10	79941966	T	C
rs2243639	24504887	3553	IL1B	umls:C0024117	BeFree	The primary aim of this study was to investigate the association between surfactant protein D (SFTPD) rs2243639, interleukin (IL)-1β rs16944 and IL-1 receptor antagonist (IL-1RN) rs2234663 gene polymorphisms and COPD susceptibility, as well as examining the association between the various IL-1RN/IL-1β haplotypes and pulmonary function tests (PFT).	0.021279544	2015	SFTPD	10	79941966	T	C
rs2250747	19796199	54738	FEV	umls:C0024117	BeFree	In females, but not in males, rs2250747 of the IL13RA1 gene was associated with COPD and lower FEV(1).	0.007871814	2010	IL13RA1	X	118729785	A	G
rs2250747	19796199	3597	IL13RA1	umls:C0024117	BeFree	In females, but not in males, rs2250747 of the IL13RA1 gene was associated with COPD and lower FEV(1).	0.002638474	2010	IL13RA1	X	118729785	A	G
rs2463822	23144326	80150	ASRGL1	umls:C0024117	GWASCAT	Genome-wide association analysis of blood biomarkers in chronic obstructive pulmonary disease.	0.12	2012	ASRGL1	11	62335948	T	C
rs2522137	24787949	4440	MSI1	umls:C0024117	BeFree	In multivariate analysis, Musashi-1 rs2522137 was still significantly associated with lung cancer when environmental and lifestyle factors were incorporated in the model, including lower BMI; family history of cancer; prior diagnosis of chronic obstructive pulmonary disease, pneumonia, or pulmonary tuberculosis; occupational exposure to pesticide; occupational exposure to gasoline or diesel fuel; heavier smoking; and exposure to heavy cooking emissions.	0.000271442	2014	MSI1	12	120342128	T	G
rs25487	19493423	7515	XRCC1	umls:C0024117	BeFree	hOGG1 Ser326Cys and XRCC1 Arg399Gln polymorphisms associated with chronic obstructive pulmonary disease.	0.00764398	2009	XRCC1	19	43551574	T	C
rs25487	19493423	4968	OGG1	umls:C0024117	BeFree	hOGG1 Ser326Cys and XRCC1 Arg399Gln polymorphisms associated with chronic obstructive pulmonary disease.	0.005276948	2009	XRCC1	19	43551574	T	C
rs2808630	23267696	140913	PPIAP10	umls:C0024117	BeFree	Haplotype analysis showed that the frequencies of the GC, GT haplotypes of rs2241718 (TGF-β1 gene), and rs6957 (CDC97 gene) were significantly higher in the control group than in the COPD case group (p=1.88×10-9); the frequencies of the TT haplotype of rs1205 and rs2808630 (CRP gene) were significantly higher in the control group (p=0.0377).	0.000271442	2012	NA	1	159711078	C	T
rs2808630	23267696	7040	TGFB1	umls:C0024117	BeFree	Haplotype analysis showed that the frequencies of the GC, GT haplotypes of rs2241718 (TGF-β1 gene), and rs6957 (CDC97 gene) were significantly higher in the control group than in the COPD case group (p=1.88×10-9); the frequencies of the TT haplotype of rs1205 and rs2808630 (CRP gene) were significantly higher in the control group (p=0.0377).	0.243744544	2012	NA	1	159711078	C	T
rs2823743	23144326	388815	MIR99AHG	umls:C0024117	GWASCAT	Genome-wide association analysis of blood biomarkers in chronic obstructive pulmonary disease.	0.12	2012	MIR99AHG	21	16295399	T	C
rs286499	25584925	1740	DLG2	umls:C0024117	GWASCAT	We have identified two novel loci (in or near the genes KLHL7/NUPL2 and DLG2) that may play a role in COPD pathogenesis in Hispanic populations.	0.120271442	2015	DLG2	11	85482825	T	G
rs28675338	21685187	123688	HYKK	umls:C0024117	GAD	[The authors identified two candidate regions associated with age at smoking initiation in patients with COPD.]	0.125005506	2011	HYKK	15	78535289	C	T
rs2869966	25241909	10144	FAM13A	umls:C0024117	GWASCAT	We found genome-wide significant associations with CB COPD on 4q22.1 (FAM13A) and 11p15.5 (EFCAB4A, CHID1 and AP2A2), and a locus associated with CB within COPD subjects on 1q23.3 (RPL31P11 and ATF6).	0.247991366	2014	FAM13A;LOC105377327	4	88947927	C	T
rs2869967	25241909	10144	FAM13A	umls:C0024117	GWASCAT	We found genome-wide significant associations with CB COPD on 4q22.1 (FAM13A) and 11p15.5 (EFCAB4A, CHID1 and AP2A2), and a locus associated with CB within COPD subjects on 1q23.3 (RPL31P11 and ATF6).	0.247991366	2014	FAM13A;LOC105377327	4	88948181	T	C
rs3130559	23144326	170679	PSORS1C1	umls:C0024117	GWASCAT	Genome-wide association analysis of blood biomarkers in chronic obstructive pulmonary disease.	0.12	2012	PSORS1C1	6	31129524	C	T
rs326118	18635682	4552	MTRR	umls:C0024117	BeFree	At the multiple logistic regression analysis adjusted for traditional cardiovascular risk factors (sex, age, hypertension, smoking habit, dyslipidaemia, diabetes) and chronic obstructive pulmonary disease (COPD), rs8003379 MTHFD1 (odds ratio (OR) 0.41, 95% confidence interval (CI) 0.26 to 0.65) and rs326118 MTRR (OR 0.47, 95% CI 0.29 to 0.77) polymorphisms resulted in independent susceptibility factor for AAA.	0.002638474	2008	MTRR;FASTKD3	5	7868430	T	G
rs34391416	25241909	283229	CRACR2B	umls:C0024117	GWASCAT	We found genome-wide significant associations with CB COPD on 4q22.1 (FAM13A) and 11p15.5 (EFCAB4A, CHID1 and AP2A2), and a locus associated with CB within COPD subjects on 1q23.3 (RPL31P11 and ATF6).	0.12	2014	CD151;CRACR2B	11	831818	G	A
rs34391416	25241909	977	CD151	umls:C0024117	GWASCAT	Genetic susceptibility for chronic bronchitis in chronic obstructive pulmonary disease.	0.12	2014	CD151;CRACR2B	11	831818	G	A
rs361525	20299531	54738	FEV	umls:C0024117	BeFree	Patients with polymorphism had more chronic bronchitis, a lower body mass index, and a greater annual decline in FEV(1) than patients with COPD without rs361525 polymorphism.	0.007871814	2010	TNF	6	31575324	G	A
rs361525	20299531	7124	TNF	umls:C0024117	GAD	[Tumor necrosis factor-{alpha} rs361525 polymorphism is associated with increased local production and downstream inflammation in chronic obstructive pulmonary disease.]	0.184914467	2010	TNF	6	31575324	G	A
rs361525	26620975	7124	TNF	umls:C0024117	BeFree	The rs361525 polymorphism does not increase production of tumor necrosis factor alpha by monocytes from alpha-1 antitrypsin deficient subjects with chronic obstructive pulmonary disease - a pilot study.	0.184914467	2015	TNF	6	31575324	G	A
rs361525	20299531	7124	TNF	umls:C0024117	BeFree	Tumor necrosis factor-{alpha} rs361525 polymorphism is associated with increased local production and downstream inflammation in chronic obstructive pulmonary disease.	0.184914467	2010	TNF	6	31575324	G	A
rs361525	26620975	5265	SERPINA1	umls:C0024117	BeFree	The rs361525 polymorphism does not increase production of tumor necrosis factor alpha by monocytes from alpha-1 antitrypsin deficient subjects with chronic obstructive pulmonary disease - a pilot study.	0.178707522	2015	TNF	6	31575324	G	A
rs3741240	23144326	7356	SCGB1A1	umls:C0024117	GWASCAT	Several SNPs highly associated with CC16 or SP-D levels were nominally associated with COPD in a collaborative GWAS (P = 0.001-0.049), although these COPD associations were not replicated in two additional cohorts.	0.120271442	2012	SCGB1A1;LOC102723765	11	62419070	G	A
rs379123	25006744	64399	HHIP	umls:C0024117	BeFree	Two are novel associations (top single-nucleotide polymorphism rs379123 in MYO1D and rs9590614 in VMA8) located within genes that function in cell-cell signaling and cell migration, and five are in loci previously associated with chronic obstructive pulmonary disease susceptibility (HHIP, IREB2/CHRNA3, CYP2A6/ADCK, TGFB2, and MMP12).	0.01272543	2014	MYO1D	17	32564796	T	C
rs379123	25006744	51382	ATP6V1D	umls:C0024117	BeFree	Two are novel associations (top single-nucleotide polymorphism rs379123 in MYO1D and rs9590614 in VMA8) located within genes that function in cell-cell signaling and cell migration, and five are in loci previously associated with chronic obstructive pulmonary disease susceptibility (HHIP, IREB2/CHRNA3, CYP2A6/ADCK, TGFB2, and MMP12).	0.000271442	2014	MYO1D	17	32564796	T	C
rs379123	25006744	4642	MYO1D	umls:C0024117	BeFree	Two are novel associations (top single-nucleotide polymorphism rs379123 in MYO1D and rs9590614 in VMA8) located within genes that function in cell-cell signaling and cell migration, and five are in loci previously associated with chronic obstructive pulmonary disease susceptibility (HHIP, IREB2/CHRNA3, CYP2A6/ADCK, TGFB2, and MMP12).	0.000271442	2014	MYO1D	17	32564796	T	C
rs379123	25006744	1136	CHRNA3	umls:C0024117	BeFree	Two are novel associations (top single-nucleotide polymorphism rs379123 in MYO1D and rs9590614 in VMA8) located within genes that function in cell-cell signaling and cell migration, and five are in loci previously associated with chronic obstructive pulmonary disease susceptibility (HHIP, IREB2/CHRNA3, CYP2A6/ADCK, TGFB2, and MMP12).	0.129077134	2014	MYO1D	17	32564796	T	C
rs379123	25006744	4321	MMP12	umls:C0024117	BeFree	Two are novel associations (top single-nucleotide polymorphism rs379123 in MYO1D and rs9590614 in VMA8) located within genes that function in cell-cell signaling and cell migration, and five are in loci previously associated with chronic obstructive pulmonary disease susceptibility (HHIP, IREB2/CHRNA3, CYP2A6/ADCK, TGFB2, and MMP12).	0.024732343	2014	MYO1D	17	32564796	T	C
rs386493716	19493423	4968	OGG1	umls:C0024117	BeFree	hOGG1 Ser326Cys and XRCC1 Arg399Gln polymorphisms associated with chronic obstructive pulmonary disease.	0.005276948	2009	NA	NA	NA	NA	NA
rs386493716	19493423	7515	XRCC1	umls:C0024117	BeFree	hOGG1 Ser326Cys and XRCC1 Arg399Gln polymorphisms associated with chronic obstructive pulmonary disease.	0.00764398	2009	NA	NA	NA	NA	NA
rs386545546	19821085	7515	XRCC1	umls:C0024117	BeFree	XRCC1 Arg194Trp polymorphism and risk of chronic obstructive pulmonary disease.	0.00764398	2009	NA	NA	NA	NA	NA
rs386603284	20160424	4321	MMP12	umls:C0024117	BeFree	To investigate the association of 3 polymorphisms of MMP genes (MMP-1 -1607G-->GG, MMP-9 -1562C-->T and MMP-12 N357S), which have been reported to be associated with COPD-related phenotypes, with the risk of COPD in a Korean population.	0.024732343	2010	NA	NA	NA	NA	NA
rs41511151	19029017	2006	ELN	umls:C0024117	GAD	[Analysis of exonic elastin variants in severe, early-onset chronic obstructive pulmonary disease.]	0.007262917	2009	ELN	7	74068657	G	A
rs4316710	22461431	10144	FAM13A	umls:C0024117	BeFree	We included three SNPs previously associated with COPD: rs7671167 (FAM13A), rs13180 (IREB2), and rs8034191 (CHRNA 3/5), and four SNPs associated with lung function in a genome-wide association study of general population samples: rs2070600 (AGER), rs11134242 (ADCY2), rs4316710 (THSD4), and rs17096090 (INTS12).	0.247991366	2012	THSD4	15	71509681	G	C
rs4316710	22461431	57117	INTS12	umls:C0024117	BeFree	We included three SNPs previously associated with COPD: rs7671167 (FAM13A), rs13180 (IREB2), and rs8034191 (CHRNA 3/5), and four SNPs associated with lung function in a genome-wide association study of general population samples: rs2070600 (AGER), rs11134242 (ADCY2), rs4316710 (THSD4), and rs17096090 (INTS12).	0.000542884	2012	THSD4	15	71509681	G	C
rs4316710	22461431	79875	THSD4	umls:C0024117	BeFree	We included three SNPs previously associated with COPD: rs7671167 (FAM13A), rs13180 (IREB2), and rs8034191 (CHRNA 3/5), and four SNPs associated with lung function in a genome-wide association study of general population samples: rs2070600 (AGER), rs11134242 (ADCY2), rs4316710 (THSD4), and rs17096090 (INTS12).	0.003181358	2012	THSD4	15	71509681	G	C
rs4416442	25241909	10144	FAM13A	umls:C0024117	GWASCAT	We found genome-wide significant associations with CB COPD on 4q22.1 (FAM13A) and 11p15.5 (EFCAB4A, CHID1 and AP2A2), and a locus associated with CB within COPD subjects on 1q23.3 (RPL31P11 and ATF6).	0.247991366	2014	FAM13A;LOC105377327	4	88945562	T	C
rs4416442	24621683	10144	FAM13A	umls:C0024117	GWASCAT	Analysis of 6633 individuals with moderate to severe COPD and 5704 control individuals confirmed association at three known loci: CHRNA3 (p=6·38 × 10(-14)), FAM13A (p=1·12 × 10(-14)), and HHIP (p=1·57 × 10(-12)).	0.247991366	2014	FAM13A;LOC105377327	4	88945562	T	C
rs4846480	24621683	7042	TGFB2	umls:C0024117	GWASCAT	Risk loci for chronic obstructive pulmonary disease: a genome-wide association study and meta-analysis.	0.12	2014	TGFB2	1	218425127	A	T
rs4986791	20169003	7099	TLR4	umls:C0024117	BeFree	Association of TLR4-T399I polymorphism with chronic obstructive pulmonary disease in smokers.	0.009087065	2009	TLR4	9	117713324	C	T
rs55645543	21685187	308	ANXA5	umls:C0024117	GAD	[The authors identified two candidate regions associated with age at smoking initiation in patients with COPD.]	0.002367032	2011	ANXA5	4	121686023	T	C
rs56238310	21685187	25945	PVRL3	umls:C0024117	GAD	[The authors identified two candidate regions associated with age at smoking initiation in patients with COPD.]	0.002367032	2011	NA	3	111514392	C	A,T
rs5743708	19381722	7097	TLR2	umls:C0024117	BeFree	Toll-like receptor 2 gene polymorphisms Arg677Trp and Arg753Gln in chronic obstructive pulmonary disease.	0.013364122	2009	TLR2	4	153705165	G	A
rs5743810	16188043	10333	TLR6	umls:C0024117	BeFree	Evaluation of the toll-like receptor 6 Ser249Pro polymorphism in patients with asthma, atopic dermatitis and chronic obstructive pulmonary disease.	0.002638474	2005	TLR6	4	38828729	A	G
rs584367	19365107	151056	PLB1	umls:C0024117	BeFree	The Gly80Ser polymorphism in phospholipase A2-IID (PLA2G2D, NCBI SNP reference: rs584367) is associated with a loss in body weight in patients with chronic obstructive pulmonary disease (COPD).	0.000542884	2009	PLA2G2D	1	20115561	T	C
rs59569785	24876173	64478	CSMD1	umls:C0024117	BeFree	The non-Hispanic white GWAS identified single nucleotide polymorphisms in the genes CSMD1 (rs11779254, p=1.57 × 10(-6)) and SOX5 (rs59569785, p=1.61 × 10(-6)) and the meta-analysis identified single nucleotide polymorphisms in the gene GPR65 (rs6574978, p=1.18 × 10(-7)) associated with COPD and asthma overlap.	0.120271442	2015	SOX5	12	23618801	C	T
rs59569785	24876173	8477	GPR65	umls:C0024117	BeFree	The non-Hispanic white GWAS identified single nucleotide polymorphisms in the genes CSMD1 (rs11779254, p=1.57 × 10(-6)) and SOX5 (rs59569785, p=1.61 × 10(-6)) and the meta-analysis identified single nucleotide polymorphisms in the gene GPR65 (rs6574978, p=1.18 × 10(-7)) associated with COPD and asthma overlap.	0.000271442	2015	SOX5	12	23618801	C	T
rs59569785	24876173	6660	SOX5	umls:C0024117	BeFree	The non-Hispanic white GWAS identified single nucleotide polymorphisms in the genes CSMD1 (rs11779254, p=1.57 × 10(-6)) and SOX5 (rs59569785, p=1.61 × 10(-6)) and the meta-analysis identified single nucleotide polymorphisms in the gene GPR65 (rs6574978, p=1.18 × 10(-7)) associated with COPD and asthma overlap.	0.000542884	2015	SOX5	12	23618801	C	T
rs6495309	23255854	1134	CHRNA1	umls:C0024117	BeFree	The rs6495309C > T polymorphism in the promoter of nicotinic acetylcholine receptor alpha subunit 3 (CHRNA3) gene was investigated in a case-control study that consisted of 406 patients with COPD and 394 healthy control subjects.	0.000542884	2012	CHRNA3;CHRNB4	15	78622903	C	T
rs652438	20160424	4321	MMP12	umls:C0024117	BeFree	To investigate the association of 3 polymorphisms of MMP genes (MMP-1 -1607G-->GG, MMP-9 -1562C-->T and MMP-12 N357S), which have been reported to be associated with COPD-related phenotypes, with the risk of COPD in a Korean population.	0.024732343	2010	MMP12	11	102865911	T	G,C
rs6574978	24876173	6660	SOX5	umls:C0024117	BeFree	The non-Hispanic white GWAS identified single nucleotide polymorphisms in the genes CSMD1 (rs11779254, p=1.57 × 10(-6)) and SOX5 (rs59569785, p=1.61 × 10(-6)) and the meta-analysis identified single nucleotide polymorphisms in the gene GPR65 (rs6574978, p=1.18 × 10(-7)) associated with COPD and asthma overlap.	0.000542884	2015	GPR65	14	88011069	C	T
rs6574978	24876173	64478	CSMD1	umls:C0024117	BeFree	The non-Hispanic white GWAS identified single nucleotide polymorphisms in the genes CSMD1 (rs11779254, p=1.57 × 10(-6)) and SOX5 (rs59569785, p=1.61 × 10(-6)) and the meta-analysis identified single nucleotide polymorphisms in the gene GPR65 (rs6574978, p=1.18 × 10(-7)) associated with COPD and asthma overlap.	0.120271442	2015	GPR65	14	88011069	C	T
rs6574978	24876173	8477	GPR65	umls:C0024117	BeFree	The non-Hispanic white GWAS identified single nucleotide polymorphisms in the genes CSMD1 (rs11779254, p=1.57 × 10(-6)) and SOX5 (rs59569785, p=1.61 × 10(-6)) and the meta-analysis identified single nucleotide polymorphisms in the gene GPR65 (rs6574978, p=1.18 × 10(-7)) associated with COPD and asthma overlap.	0.000271442	2015	GPR65	14	88011069	C	T
rs6585424	23144326	311	ANXA11	umls:C0024117	GWASCAT	Genome-wide association analysis of blood biomarkers in chronic obstructive pulmonary disease.	0.12	2012	ANXA11	10	80173992	A	G
rs6609533	21763297	5265	SERPINA1	umls:C0024117	BeFree	PIM3 allele of α(1)AT gene in COPD patients was found to be associated with low levels of α(1)AT (P = 0.001), the effect being more pronounced when PIM3 combined with rs6609533 of TIMP-1 gene (P = 0.0001).	0.178707522	2011	SYN1;TIMP1;MIR4769	X	47585887	A	G
rs6609533	21763297	415116	PIM3	umls:C0024117	BeFree	PIM3 allele of α(1)AT gene in COPD patients was found to be associated with low levels of α(1)AT (P = 0.001), the effect being more pronounced when PIM3 combined with rs6609533 of TIMP-1 gene (P = 0.0001).	0.000542884	2011	SYN1;TIMP1;MIR4769	X	47585887	A	G
rs6957	23267696	7040	TGFB1	umls:C0024117	BeFree	Haplotype analysis showed that the frequencies of the GC, GT haplotypes of rs2241718 (TGF-β1 gene), and rs6957 (CDC97 gene) were significantly higher in the control group than in the COPD case group (p=1.88×10-9); the frequencies of the TT haplotype of rs1205 and rs2808630 (CRP gene) were significantly higher in the control group (p=0.0377).	0.243744544	2012	CCDC97	19	41324701	T	C
rs6957	23267696	140913	PPIAP10	umls:C0024117	BeFree	Haplotype analysis showed that the frequencies of the GC, GT haplotypes of rs2241718 (TGF-β1 gene), and rs6957 (CDC97 gene) were significantly higher in the control group than in the COPD case group (p=1.88×10-9); the frequencies of the TT haplotype of rs1205 and rs2808630 (CRP gene) were significantly higher in the control group (p=0.0377).	0.000271442	2012	CCDC97	19	41324701	T	C
rs7078012	23144326	6441	SFTPD	umls:C0024117	GWASCAT	Several SNPs highly associated with CC16 or SP-D levels were nominally associated with COPD in a collaborative GWAS (P = 0.001-0.049), although these COPD associations were not replicated in two additional cohorts.	0.210172833	2012	SFTPD	10	79945677	C	T
rs7181486	25101718	3658	IREB2	umls:C0024117	GWASCAT	IREB2 and GALC are associated with pulmonary artery enlargement in chronic obstructive pulmonary disease.	0.129272631	2015	IREB2	15	78449276	T	C
rs728616	23144326	80195	TMEM254	umls:C0024117	GWASCAT	Genome-wide association analysis of blood biomarkers in chronic obstructive pulmonary disease.	0.12	2012	TMEM254	10	80088158	G	T
rs73717741	21685187	9425	CDYL	umls:C0024117	GAD	[The authors identified two candidate regions associated with age at smoking initiation in patients with COPD.]	0.002367032	2011	CDYL	6	4874525	C	G
rs754388	25101718	79890	RIN3	umls:C0024117	GWASCAT	IREB2 and GALC are associated with pulmonary artery enlargement in chronic obstructive pulmonary disease.	0.12	2015	RIN3	14	92649065	G	C
rs754388	24621683	79890	RIN3	umls:C0024117	GWASCAT	Risk loci for chronic obstructive pulmonary disease: a genome-wide association study and meta-analysis.	0.12	2014	RIN3	14	92649065	G	C
rs76351433	21685187	9655	SOCS5	umls:C0024117	GAD	[The authors identified two candidate regions associated with age at smoking initiation in patients with COPD.]	0.002367032	2011	NA	2	46795404	A	C
rs763780	16961709	112744	IL17F	umls:C0024117	BeFree	Given that asthma and COPD are complex diseases involving a number of genetic and environmental factors, the genetic impact of IL-17F H161R with regard to the development of chronic airway inflammation likely varies among individuals with different genetic backgrounds and environmental exposures.	0.000814326	2006	IL17F;LOC105375088	6	52236941	T	C
rs7655841	24621683	132320	SCLT1	umls:C0024117	GWASCAT	Risk loci for chronic obstructive pulmonary disease: a genome-wide association study and meta-analysis.	0.12	2014	SCLT1	4	128969635	T	C
rs7671167	20173748	10144	FAM13A	umls:C0024117	GWASCAT	Variants in FAM13A are associated with chronic obstructive pulmonary disease.	0.247991366	2010	FAM13A	4	88962828	C	T
rs7671167	22461431	79875	THSD4	umls:C0024117	BeFree	We included three SNPs previously associated with COPD: rs7671167 (FAM13A), rs13180 (IREB2), and rs8034191 (CHRNA 3/5), and four SNPs associated with lung function in a genome-wide association study of general population samples: rs2070600 (AGER), rs11134242 (ADCY2), rs4316710 (THSD4), and rs17096090 (INTS12).	0.003181358	2012	FAM13A	4	88962828	C	T
rs7671167	20173748	10144	FAM13A	umls:C0024117	GAD	[Variants in FAM13A are associated with chronic obstructive pulmonary disease.]	0.247991366	2010	FAM13A	4	88962828	C	T
rs7671167	22461431	57117	INTS12	umls:C0024117	BeFree	We included three SNPs previously associated with COPD: rs7671167 (FAM13A), rs13180 (IREB2), and rs8034191 (CHRNA 3/5), and four SNPs associated with lung function in a genome-wide association study of general population samples: rs2070600 (AGER), rs11134242 (ADCY2), rs4316710 (THSD4), and rs17096090 (INTS12).	0.000542884	2012	FAM13A	4	88962828	C	T
rs7671167	22461431	10144	FAM13A	umls:C0024117	BeFree	We included three SNPs previously associated with COPD: rs7671167 (FAM13A), rs13180 (IREB2), and rs8034191 (CHRNA 3/5), and four SNPs associated with lung function in a genome-wide association study of general population samples: rs2070600 (AGER), rs11134242 (ADCY2), rs4316710 (THSD4), and rs17096090 (INTS12).	0.247991366	2012	FAM13A	4	88962828	C	T
rs7674369	25101718	10144	FAM13A	umls:C0024117	GWASCAT	IREB2 and GALC are associated with pulmonary artery enlargement in chronic obstructive pulmonary disease.	0.247991366	2015	FAM13A;LOC105377327	4	88951025	G	A
rs76884941	21685187	25945	PVRL3	umls:C0024117	GAD	[The authors identified two candidate regions associated with age at smoking initiation in patients with COPD.]	0.002367032	2011	NA	3	111482938	T	G
rs7937	22080838	53916	RAB4B	umls:C0024117	GAD	[A genome-wide association study of COPD identifies a susceptibility locus on chromosome 19q13.]	0.002367032	2012	RAB4B;MIA-RAB4B;RAB4B-EGLN2	19	40796801	C	T
rs7937	22080838	100529264	RAB4B-EGLN2	umls:C0024117	GWASCAT	A genome-wide association study of COPD identifies a susceptibility locus on chromosome 19q13.	0.12	2012	RAB4B;MIA-RAB4B;RAB4B-EGLN2	19	40796801	C	T
rs7937	22080838	100529262	MIA-RAB4B	umls:C0024117	GWASCAT	A genome-wide association study of COPD identifies a susceptibility locus on chromosome 19q13.	0.12	2012	RAB4B;MIA-RAB4B;RAB4B-EGLN2	19	40796801	C	T
rs8003379	18635682	4552	MTRR	umls:C0024117	BeFree	At the multiple logistic regression analysis adjusted for traditional cardiovascular risk factors (sex, age, hypertension, smoking habit, dyslipidaemia, diabetes) and chronic obstructive pulmonary disease (COPD), rs8003379 MTHFD1 (odds ratio (OR) 0.41, 95% confidence interval (CI) 0.26 to 0.65) and rs326118 MTRR (OR 0.47, 95% CI 0.29 to 0.77) polymorphisms resulted in independent susceptibility factor for AAA.	0.002638474	2008	MTHFD1	14	64406881	A	C
rs8034191	19300482	123688	HYKK	umls:C0024117	GAD	[A genome-wide association study in chronic obstructive pulmonary disease (COPD): identification of two major susceptibility loci.]	0.125005506	2009	HYKK	15	78513681	T	C
rs8034191	19300482	1136	CHRNA3	umls:C0024117	GAD	[The CHRNA 3/5 and the HHIP loci make a significant contribution to the risk of COPD.]	0.129077134	2009	HYKK	15	78513681	T	C
rs8034191	19300482	1138	CHRNA5	umls:C0024117	GAD	[A genome-wide association study in chronic obstructive pulmonary disease (COPD): identification of two major susceptibility loci.]	0.127177041	2009	HYKK	15	78513681	T	C
rs8034191	22461431	57117	INTS12	umls:C0024117	BeFree	We included three SNPs previously associated with COPD: rs7671167 (FAM13A), rs13180 (IREB2), and rs8034191 (CHRNA 3/5), and four SNPs associated with lung function in a genome-wide association study of general population samples: rs2070600 (AGER), rs11134242 (ADCY2), rs4316710 (THSD4), and rs17096090 (INTS12).	0.000542884	2012	HYKK	15	78513681	T	C
rs8034191	19300482	123688	HYKK	umls:C0024117	GWASCAT	A genome-wide association study in chronic obstructive pulmonary disease (COPD): identification of two major susceptibility loci.	0.125005506	2009	HYKK	15	78513681	T	C
rs8034191	22461431	10144	FAM13A	umls:C0024117	BeFree	We included three SNPs previously associated with COPD: rs7671167 (FAM13A), rs13180 (IREB2), and rs8034191 (CHRNA 3/5), and four SNPs associated with lung function in a genome-wide association study of general population samples: rs2070600 (AGER), rs11134242 (ADCY2), rs4316710 (THSD4), and rs17096090 (INTS12).	0.247991366	2012	HYKK	15	78513681	T	C
rs8034191	19300482	3658	IREB2	umls:C0024117	GAD	[A genome-wide association study in chronic obstructive pulmonary disease (COPD): identification of two major susceptibility loci.]	0.129272631	2009	HYKK	15	78513681	T	C
rs8034191	19300482	5685	PSMA4	umls:C0024117	GAD	[A genome-wide association study in chronic obstructive pulmonary disease (COPD): identification of two major susceptibility loci.]	0.002367032	2009	HYKK	15	78513681	T	C
rs8034191	19300482	1137	CHRNA4	umls:C0024117	GAD	[A genome-wide association study in chronic obstructive pulmonary disease (COPD): identification of two major susceptibility loci.]	0.002638474	2009	HYKK	15	78513681	T	C
rs8034191	22461431	79875	THSD4	umls:C0024117	BeFree	We included three SNPs previously associated with COPD: rs7671167 (FAM13A), rs13180 (IREB2), and rs8034191 (CHRNA 3/5), and four SNPs associated with lung function in a genome-wide association study of general population samples: rs2070600 (AGER), rs11134242 (ADCY2), rs4316710 (THSD4), and rs17096090 (INTS12).	0.003181358	2012	HYKK	15	78513681	T	C
rs8042238	25241909	3658	IREB2	umls:C0024117	GWASCAT	Genetic susceptibility for chronic bronchitis in chronic obstructive pulmonary disease.	0.129272631	2014	IREB2	15	78481929	C	T
rs8048576	23144326	9914	ATP2C2	umls:C0024117	GWASCAT	Genome-wide association analysis of blood biomarkers in chronic obstructive pulmonary disease.	0.12	2012	ATP2C2	16	84389428	G	A
rs858249	25584925	11097	NUPL2	umls:C0024117	GWASCAT	We have identified two novel loci (in or near the genes KLHL7/NUPL2 and DLG2) that may play a role in COPD pathogenesis in Hispanic populations.	0.120271442	2015	NUPL2	7	23181020	A	G
rs911887	20448057	54738	FEV	umls:C0024117	BeFree	In the family-based analysis of the Boston Early-Onset COPD Study, rs911887 was associated with prebronchodilator and postbronchodilator FEV(1) (P = 0.003 and P = 0.02, respectively).	0.007871814	2011	SFTPD	10	79941767	T	C
rs9296092	21685187	221504	ZBTB9	umls:C0024117	GAD	[The authors identified two candidate regions associated with age at smoking initiation in patients with COPD.]	0.002367032	2011	NA	6	33510719	A	G
rs9394152	21685187	221504	ZBTB9	umls:C0024117	GAD	[The authors identified two candidate regions associated with age at smoking initiation in patients with COPD.]	0.002367032	2011	NA	6	33497705	C	T
rs9590614	25006744	51382	ATP6V1D	umls:C0024117	BeFree	Two are novel associations (top single-nucleotide polymorphism rs379123 in MYO1D and rs9590614 in VMA8) located within genes that function in cell-cell signaling and cell migration, and five are in loci previously associated with chronic obstructive pulmonary disease susceptibility (HHIP, IREB2/CHRNA3, CYP2A6/ADCK, TGFB2, and MMP12).	0.000271442	2014	VWA8	13	41601452	G	C
rs9590614	25006744	4321	MMP12	umls:C0024117	BeFree	Two are novel associations (top single-nucleotide polymorphism rs379123 in MYO1D and rs9590614 in VMA8) located within genes that function in cell-cell signaling and cell migration, and five are in loci previously associated with chronic obstructive pulmonary disease susceptibility (HHIP, IREB2/CHRNA3, CYP2A6/ADCK, TGFB2, and MMP12).	0.024732343	2014	VWA8	13	41601452	G	C
rs9590614	25006744	64399	HHIP	umls:C0024117	BeFree	Two are novel associations (top single-nucleotide polymorphism rs379123 in MYO1D and rs9590614 in VMA8) located within genes that function in cell-cell signaling and cell migration, and five are in loci previously associated with chronic obstructive pulmonary disease susceptibility (HHIP, IREB2/CHRNA3, CYP2A6/ADCK, TGFB2, and MMP12).	0.01272543	2014	VWA8	13	41601452	G	C
rs9590614	25006744	4642	MYO1D	umls:C0024117	BeFree	Two are novel associations (top single-nucleotide polymorphism rs379123 in MYO1D and rs9590614 in VMA8) located within genes that function in cell-cell signaling and cell migration, and five are in loci previously associated with chronic obstructive pulmonary disease susceptibility (HHIP, IREB2/CHRNA3, CYP2A6/ADCK, TGFB2, and MMP12).	0.000271442	2014	VWA8	13	41601452	G	C
rs9590614	25006744	1136	CHRNA3	umls:C0024117	BeFree	Two are novel associations (top single-nucleotide polymorphism rs379123 in MYO1D and rs9590614 in VMA8) located within genes that function in cell-cell signaling and cell migration, and five are in loci previously associated with chronic obstructive pulmonary disease susceptibility (HHIP, IREB2/CHRNA3, CYP2A6/ADCK, TGFB2, and MMP12).	0.129077134	2014	VWA8	13	41601452	G	C

GWASdb Annotation(Total Genotypes:0)
(Waiting for update.)

GWASdb Snp Trait(Total Genotypes:367)
CHR	POS	SNPID	REF	ALT	ORI_SNPID	PMID	P_VALUE	P_VALUE_TEXT	OR/BETA	CI95_TEXT	GWAS_INITIAL_SAMPLE_SIZE	SUB_POPULATION	SUPER_POPULATION	GWAS_TRAIT	HPO_ID	HPO_TERM	DO_ID	DO_TERM	MESH_ID	MESH_TERM	EFO_ID	EFO_TERM	DOLITE_TERM	RISK_ALLELE	PUBLICATION_TYPE	AA	GENE_SYMBOL	TYPE	REFGENE
1	15347640	rs6667220	G	A	rs6667220	23144326	8.00E-06	IL6	NA	NA	Up to 1,951 European ancestry smokers	European(1951)	ALL(1951)	EUR(1951)	ALL(1951)	Chronic obstructive pulmonary disease-related biomarkers	HPOID:0006510	Chronic obstructive pulmonary disease	DOID:3083	chronic obstructive pulmonary disease	D029424	Pulmonary Disease, Chronic Obstructive	EFOID:0005080	surfactant protein D measurement	Chronic obstructive airway disease	rs6667220-G	Clinical Trial	Research Support, N.I.H., Extramural	Research Support, Non-U.S. Gov't
1	21736327	rs12750103	A	G	rs12750103	22837378	9.00E-11	NA	NA	NA	up to 3,368 European ancestry cases; up to 29,507 European ancestry controls	European(32875)	ALL(32875)	EUR(32875)	ALL(32875)	Airflow obstruction	HPOID:0006536	Obstructive lung disease	DOID:3083	chronic obstructive pulmonary disease	D000402	Airway Obstruction	EFOID:0003892	pulmonary function measurement	Chronic obstructive airway disease	NA	Research Support, N.I.H., Extramural	Meta-Analysis	Research Support, Non-U.S. Gov't
1	25421990	rs11588172	T	C	rs11588172	19300482	9.02E-06	NA	NA	NA	823 cases; 810 controls	NOPOP(1633)	ALL(1633)	NOPOP(1633)	ALL(1633)	Chronic obstructive pulmonary disease	HPOID:0006510	Chronic obstructive pulmonary disease	DOID:3083	chronic obstructive pulmonary disease	D029424	Pulmonary Disease, Chronic Obstructive	EFOID:0000341	chronic obstructive pulmonary disease	Chronic obstructive airway disease	NA	Research Support, N.I.H., Extramural	Research Support, U.S. Gov't, P.H.S.	Research Support, Non-U.S. Gov't
1	26085398	rs12130495	G	T	rs12130495	24383474	1.10E-04	NA	0.07	[0.03-0.11] unit decrease	2,587 European ancestry individuals; 2,510 African American individuals; 2,113 Hispanic individuals; 704 Chinese ancestry individuals	Chinese(704)	African American(2510)	European(2587)	Hispanic(2113)	ALL(7914)	ASN(704)	HIS(2113)	AFR(2510)	EUR(2587)	ALL(7914)	Pulmonary emphysema	HPOID:0006510	Chronic obstructive pulmonary disease	DOID:9675	pulmonary emphysema	NA	NA	NA
1	37967774	rs215864	C	A	rs215864	19300482	3.30E-05	NA	NA	NA	823 cases; 810 controls	NOPOP(1633)	ALL(1633)	NOPOP(1633)	ALL(1633)	Chronic obstructive pulmonary disease	HPOID:0006510	Chronic obstructive pulmonary disease	DOID:3083	chronic obstructive pulmonary disease	D029424	Pulmonary Disease, Chronic Obstructive	EFOID:0000341	chronic obstructive pulmonary disease	Chronic obstructive airway disease	NA	Research Support, N.I.H., Extramural	Research Support, U.S. Gov't, P.H.S.	Research Support, Non-U.S. Gov't
1	38805929	rs11210569	T	C	rs11210569	19300482	4.40E-05	NA	NA	NA	823 cases; 810 controls	NOPOP(1633)	ALL(1633)	NOPOP(1633)	ALL(1633)	Chronic obstructive pulmonary disease	HPOID:0006510	Chronic obstructive pulmonary disease	DOID:3083	chronic obstructive pulmonary disease	D029424	Pulmonary Disease, Chronic Obstructive	EFOID:0000341	chronic obstructive pulmonary disease	Chronic obstructive airway disease	NA	Research Support, N.I.H., Extramural	Research Support, U.S. Gov't, P.H.S.	Research Support, Non-U.S. Gov't
1	41293419	rs3767943	G	A	rs3767943	19300482	9.18E-05	NA	NA	NA	823 cases; 810 controls	NOPOP(1633)	ALL(1633)	NOPOP(1633)	ALL(1633)	Chronic obstructive pulmonary disease	HPOID:0006510	Chronic obstructive pulmonary disease	DOID:3083	chronic obstructive pulmonary disease	D029424	Pulmonary Disease, Chronic Obstructive	EFOID:0000341	chronic obstructive pulmonary disease	Chronic obstructive airway disease	NA	Research Support, N.I.H., Extramural	Research Support, U.S. Gov't, P.H.S.	Research Support, Non-U.S. Gov't
1	53536025	rs2275456	T	C	rs2275456	22986903	0.0000031	NA	NA	NA	4,048 European ancestry cases	European(4048)	ALL(4048)	EUR(4048)	ALL(4048)	Chronic obstructive pulmonary disease (moderate to severe)	HPOID:0006510	Chronic obstructive pulmonary disease	DOID:3083	chronic obstructive pulmonary disease	NA	NA	NA	NA	Chronic obstructive airway disease	NA	Multicenter Study	Research Support, N.I.H., Extramural	Research Support, Non-U.S. Gov't
1	53871085	rs114216682	G	C	rs114216682	21685187	7.00E-08	Smoking cessation	4.49	NA	3,441 Caucasian ever-smokers with COPD	Caucasian(3441)	ALL(3441)	EUR(3441)	ALL(3441)	Chronic obstructive pulmonary disease	HPOID:0006510	Chronic obstructive pulmonary disease	DOID:3083	chronic obstructive pulmonary disease	D029424	Pulmonary Disease, Chronic Obstructive	EFOID:0000341	chronic obstructive pulmonary disease	Chronic obstructive airway disease	rs114216682-G	Randomized Controlled Trial	Multicenter Study	Research Support, N.I.H., Extramural
1	56359813	rs6684428	T	A	rs6684428	22837378	5.00E-07	Smoker	1.23	NA	up to 3,368 European ancestry cases; up to 29,507 European ancestry controls	European(32875)	ALL(32875)	EUR(32875)	ALL(32875)	Airflow obstruction	HPOID:0006536	Obstructive lung disease	DOID:3083	chronic obstructive pulmonary disease	D000402	Airway Obstruction	EFOID:0003892	pulmonary function measurement	Chronic obstructive airway disease	rs6684428-A	Research Support, N.I.H., Extramural	Meta-Analysis	Research Support, Non-U.S. Gov't
1	68785213	rs11209261	T	A	rs11209261	22837378	3.00E-06	FEV1 65%	1.23	NA	up to 3,368 European ancestry cases; up to 29,507 European ancestry controls	European(32875)	ALL(32875)	EUR(32875)	ALL(32875)	Airflow obstruction	HPOID:0006536	Obstructive lung disease	DOID:3083	chronic obstructive pulmonary disease	D000402	Airway Obstruction	EFOID:0003892	pulmonary function measurement	Chronic obstructive airway disease	NA	Research Support, N.I.H., Extramural	Meta-Analysis	Research Support, Non-U.S. Gov't
1	79682535	rs7529406	A	C	rs7529406	19300482	6.13E-05	NA	NA	NA	823 cases; 810 controls	NOPOP(1633)	ALL(1633)	NOPOP(1633)	ALL(1633)	Chronic obstructive pulmonary disease	HPOID:0006510	Chronic obstructive pulmonary disease	DOID:3083	chronic obstructive pulmonary disease	D029424	Pulmonary Disease, Chronic Obstructive	EFOID:0000341	chronic obstructive pulmonary disease	Chronic obstructive airway disease	NA	Research Support, N.I.H., Extramural	Research Support, U.S. Gov't, P.H.S.	Research Support, Non-U.S. Gov't
1	163500711	rs3001089	T	G	rs3001089	24621683	5.00E-07	(AA)	NA	NA	5,812 European ancestry cases; 3,955 European ancestry controls; 821 African American cases; 1,749 African American controls	African American(2570)	European(9767)	ALL(12337)	AFR(2570)	EUR(9767)	ALL(12337)	Chronic obstructive pulmonary disease (moderate to severe)	HPOID:0006510	Chronic obstructive pulmonary disease	DOID:3083	chronic obstructive pulmonary disease	NA	NA	NA	NA	Chronic obstructive airway disease	NA	Research Support, N.I.H., Extramural
1	165935581	rs7524799	T	C	rs7524799	19300482	6.74E-06	NA	NA	NA	823 cases; 810 controls	NOPOP(1633)	ALL(1633)	NOPOP(1633)	ALL(1633)	Chronic obstructive pulmonary disease	HPOID:0006510	Chronic obstructive pulmonary disease	DOID:3083	chronic obstructive pulmonary disease	D029424	Pulmonary Disease, Chronic Obstructive	EFOID:0000341	chronic obstructive pulmonary disease	Chronic obstructive airway disease	NA	Research Support, N.I.H., Extramural	Research Support, U.S. Gov't, P.H.S.	Research Support, Non-U.S. Gov't
1	165961938	rs7522756	A	G	rs7522756	19300482	1.44E-05	NA	NA	NA	823 cases; 810 controls	NOPOP(1633)	ALL(1633)	NOPOP(1633)	ALL(1633)	Chronic obstructive pulmonary disease	HPOID:0006510	Chronic obstructive pulmonary disease	DOID:3083	chronic obstructive pulmonary disease	D029424	Pulmonary Disease, Chronic Obstructive	EFOID:0000341	chronic obstructive pulmonary disease	Chronic obstructive airway disease	NA	Research Support, N.I.H., Extramural	Research Support, U.S. Gov't, P.H.S.	Research Support, Non-U.S. Gov't
1	165967420	rs732285	G	A	rs732285	19300482	4.86E-05	NA	NA	NA	823 cases; 810 controls	NOPOP(1633)	ALL(1633)	NOPOP(1633)	ALL(1633)	Chronic obstructive pulmonary disease	HPOID:0006510	Chronic obstructive pulmonary disease	DOID:3083	chronic obstructive pulmonary disease	D029424	Pulmonary Disease, Chronic Obstructive	EFOID:0000341	chronic obstructive pulmonary disease	Chronic obstructive airway disease	NA	Research Support, N.I.H., Extramural	Research Support, U.S. Gov't, P.H.S.	Research Support, Non-U.S. Gov't
1	165996331	rs6426962	A	C	rs6426962	19300482	1.94E-05	NA	NA	NA	823 cases; 810 controls	NOPOP(1633)	ALL(1633)	NOPOP(1633)	ALL(1633)	Chronic obstructive pulmonary disease	HPOID:0006510	Chronic obstructive pulmonary disease	DOID:3083	chronic obstructive pulmonary disease	D029424	Pulmonary Disease, Chronic Obstructive	EFOID:0000341	chronic obstructive pulmonary disease	Chronic obstructive airway disease	NA	Research Support, N.I.H., Extramural	Research Support, U.S. Gov't, P.H.S.	Research Support, Non-U.S. Gov't
1	181042889	rs6682093	G	A	rs6682093	23990791	1.03E-05	imputed, conditional on PI S and Z alleles in GWAS stage only	0.03	NA	1,392 European ancestry individuals	European(1392)	ALL(1392)	EUR(1392)	ALL(1392)	Serum alpha1-antitrypsin levels	HPOID:0006510	Chronic obstructive pulmonary disease	DOID:3083	chronic obstructive pulmonary disease	NA	NA	NA	NA	Chronic obstructive airway disease	NA	Research Support, N.I.H., Extramural	Research Support, Non-U.S. Gov't	Research Support, U.S. Gov't, Non-P.H.S.
1	181046368	rs3856068	A	C	rs3856068	23990791	1.67E-05	imputed, conditional on PI S and Z alleles in GWAS stage only	0.03	NA	1,392 European ancestry individuals	European(1392)	ALL(1392)	EUR(1392)	ALL(1392)	Serum alpha1-antitrypsin levels	HPOID:0006510	Chronic obstructive pulmonary disease	DOID:3083	chronic obstructive pulmonary disease	NA	NA	NA	NA	Chronic obstructive airway disease	NA	Research Support, N.I.H., Extramural	Research Support, Non-U.S. Gov't	Research Support, U.S. Gov't, Non-P.H.S.
1	181056160	rs6662507	G	A	rs6662507	23990791	1.42E-05	imputed, conditional on PI S and Z alleles in GWAS stage only	0.03	NA	1,392 European ancestry individuals	European(1392)	ALL(1392)	EUR(1392)	ALL(1392)	Serum alpha1-antitrypsin levels	HPOID:0006510	Chronic obstructive pulmonary disease	DOID:3083	chronic obstructive pulmonary disease	NA	NA	NA	NA	Chronic obstructive airway disease	NA	Research Support, N.I.H., Extramural	Research Support, Non-U.S. Gov't	Research Support, U.S. Gov't, Non-P.H.S.
1	181065807	rs2275470	G	A	rs2275470	23990791	1.79E-05	imputed, conditional on PI S and Z alleles in GWAS stage only	0.03	NA	1,392 European ancestry individuals	European(1392)	ALL(1392)	EUR(1392)	ALL(1392)	Serum alpha1-antitrypsin levels	HPOID:0006510	Chronic obstructive pulmonary disease	DOID:3083	chronic obstructive pulmonary disease	NA	NA	NA	NA	Chronic obstructive airway disease	NA	Research Support, N.I.H., Extramural	Research Support, Non-U.S. Gov't	Research Support, U.S. Gov't, Non-P.H.S.
1	186454429	rs497285	C	A	rs497285	23990791	2.94E-05	imputed, conditional on PI S and Z alleles in GWAS stage only	0.04	NA	1,392 European ancestry individuals	European(1392)	ALL(1392)	EUR(1392)	ALL(1392)	Serum alpha1-antitrypsin levels	HPOID:0006510	Chronic obstructive pulmonary disease	DOID:3083	chronic obstructive pulmonary disease	NA	NA	NA	NA	Chronic obstructive airway disease	NA	Research Support, N.I.H., Extramural	Research Support, Non-U.S. Gov't	Research Support, U.S. Gov't, Non-P.H.S.
1	186456336	rs480075	A	G	rs480075	23990791	2.76E-05	imputed, conditional on PI S and Z alleles in GWAS stage only	0.04	NA	1,392 European ancestry individuals	European(1392)	ALL(1392)	EUR(1392)	ALL(1392)	Serum alpha1-antitrypsin levels	HPOID:0006510	Chronic obstructive pulmonary disease	DOID:3083	chronic obstructive pulmonary disease	NA	NA	NA	NA	Chronic obstructive airway disease	NA	Research Support, N.I.H., Extramural	Research Support, Non-U.S. Gov't	Research Support, U.S. Gov't, Non-P.H.S.
1	186548140	rs1013665	C	T	rs1013665	23990791	1.05E-05	imputed, conditional on PI S and Z alleles in GWAS stage only	0.04	NA	1,392 European ancestry individuals	European(1392)	ALL(1392)	EUR(1392)	ALL(1392)	Serum alpha1-antitrypsin levels	HPOID:0006510	Chronic obstructive pulmonary disease	DOID:3083	chronic obstructive pulmonary disease	NA	NA	NA	NA	Chronic obstructive airway disease	NA	Research Support, N.I.H., Extramural	Research Support, Non-U.S. Gov't	Research Support, U.S. Gov't, Non-P.H.S.
1	186599018	rs7514491	T	C	rs7514491	23990791	1.19E-05	imputed, conditional on PI S and Z alleles in GWAS stage only	0.04	NA	1,392 European ancestry individuals	European(1392)	ALL(1392)	EUR(1392)	ALL(1392)	Serum alpha1-antitrypsin levels	HPOID:0006510	Chronic obstructive pulmonary disease	DOID:3083	chronic obstructive pulmonary disease	NA	NA	NA	NA	Chronic obstructive airway disease	NA	Research Support, N.I.H., Extramural	Research Support, Non-U.S. Gov't	Research Support, U.S. Gov't, Non-P.H.S.
1	186642429	rs2206593	A	G	rs2206593	23990791	4.60E-06	imputed, conditional on PI S and Z alleles in GWAS stage only	0.06	NA	1,392 European ancestry individuals	European(1392)	ALL(1392)	EUR(1392)	ALL(1392)	Serum alpha1-antitrypsin levels	HPOID:0006510	Chronic obstructive pulmonary disease	DOID:3083	chronic obstructive pulmonary disease	NA	NA	NA	NA	Chronic obstructive airway disease	NA	Research Support, N.I.H., Extramural	Research Support, Non-U.S. Gov't	Research Support, U.S. Gov't, Non-P.H.S.
1	186649221	rs2745557	A	G	rs2745557	23990791	2.43E-05	imputed, conditional on PI S and Z alleles in GWAS stage only	0.04	NA	1,392 European ancestry individuals	European(1392)	ALL(1392)	EUR(1392)	ALL(1392)	Serum alpha1-antitrypsin levels	HPOID:0006510	Chronic obstructive pulmonary disease	DOID:3083	chronic obstructive pulmonary disease	NA	NA	NA	NA	Chronic obstructive airway disease	NA	Research Support, N.I.H., Extramural	Research Support, Non-U.S. Gov't	Research Support, U.S. Gov't, Non-P.H.S.
1	186652002	rs2745559	A	C	rs2745559	23990791	3.03E-05	imputed, conditional on PI S and Z alleles in GWAS stage only	0.04	NA	1,392 European ancestry individuals	European(1392)	ALL(1392)	EUR(1392)	ALL(1392)	Serum alpha1-antitrypsin levels	HPOID:0006510	Chronic obstructive pulmonary disease	DOID:3083	chronic obstructive pulmonary disease	NA	NA	NA	NA	Chronic obstructive airway disease	NA	Research Support, N.I.H., Extramural	Research Support, Non-U.S. Gov't	Research Support, U.S. Gov't, Non-P.H.S.
1	186658072	rs1119065	C	T	rs1119065	23990791	1.03E-05	imputed, conditional on PI S and Z alleles in GWAS stage only	0.06	NA	1,392 European ancestry individuals	European(1392)	ALL(1392)	EUR(1392)	ALL(1392)	Serum alpha1-antitrypsin levels	HPOID:0006510	Chronic obstructive pulmonary disease	DOID:3083	chronic obstructive pulmonary disease	NA	NA	NA	NA	Chronic obstructive airway disease	NA	Research Support, N.I.H., Extramural	Research Support, Non-U.S. Gov't	Research Support, U.S. Gov't, Non-P.H.S.
1	210923061	rs4951563	A	G	rs4951563	19300482	1.73E-05	NA	NA	NA	823 cases; 810 controls	NOPOP(1633)	ALL(1633)	NOPOP(1633)	ALL(1633)	Chronic obstructive pulmonary disease	HPOID:0006510	Chronic obstructive pulmonary disease	DOID:3083	chronic obstructive pulmonary disease	D029424	Pulmonary Disease, Chronic Obstructive	EFOID:0000341	chronic obstructive pulmonary disease	Chronic obstructive airway disease	NA	Research Support, N.I.H., Extramural	Research Support, U.S. Gov't, P.H.S.	Research Support, Non-U.S. Gov't
1	218598469	rs4846480	A	T	rs4846480	24621683	8.00E-09	NA	NA	NA	3,145 European ancestry cases; 3,955 European ancestry controls; 352 African American cases; 1,749 African American controls	African American(2101)	European(7100)	ALL(9201)	AFR(2101)	EUR(7100)	ALL(9201)	Chronic obstructive pulmonary disease (severe)	HPOID:0006510	Chronic obstructive pulmonary disease	DOID:3083	chronic obstructive pulmonary disease	NA	NA	NA	NA	Chronic obstructive airway disease	rs4846480-A	Research Support, N.I.H., Extramural
1	223469434	rs17161994	C	G	rs17161994	19300482	9.46E-05	NA	NA	NA	823 cases; 810 controls	NOPOP(1633)	ALL(1633)	NOPOP(1633)	ALL(1633)	Chronic obstructive pulmonary disease	HPOID:0006510	Chronic obstructive pulmonary disease	DOID:3083	chronic obstructive pulmonary disease	D029424	Pulmonary Disease, Chronic Obstructive	EFOID:0000341	chronic obstructive pulmonary disease	Chronic obstructive airway disease	NA	Research Support, N.I.H., Extramural	Research Support, U.S. Gov't, P.H.S.	Research Support, Non-U.S. Gov't
1	235760817	rs10926189	C	T	rs10926189	19300482	9.95E-05	NA	NA	NA	823 cases; 810 controls	NOPOP(1633)	ALL(1633)	NOPOP(1633)	ALL(1633)	Chronic obstructive pulmonary disease	HPOID:0006510	Chronic obstructive pulmonary disease	DOID:3083	chronic obstructive pulmonary disease	D029424	Pulmonary Disease, Chronic Obstructive	EFOID:0000341	chronic obstructive pulmonary disease	Chronic obstructive airway disease	NA	Research Support, N.I.H., Extramural	Research Support, U.S. Gov't, P.H.S.	Research Support, Non-U.S. Gov't
2	13021683	rs10182783	G	A	rs10182783	23990791	3.37E-05	imputed, conditional on PI S and Z alleles in GWAS stage only	0.04	NA	1,392 European ancestry individuals	European(1392)	ALL(1392)	EUR(1392)	ALL(1392)	Serum alpha1-antitrypsin levels	HPOID:0006510	Chronic obstructive pulmonary disease	DOID:3083	chronic obstructive pulmonary disease	NA	NA	NA	NA	Chronic obstructive airway disease	NA	Research Support, N.I.H., Extramural	Research Support, Non-U.S. Gov't	Research Support, U.S. Gov't, Non-P.H.S.
2	13041090	rs6728142	T	C	rs6728142	23990791	4.54E-05	imputed, conditional on PI S and Z alleles in GWAS stage only	0.04	NA	1,392 European ancestry individuals	European(1392)	ALL(1392)	EUR(1392)	ALL(1392)	Serum alpha1-antitrypsin levels	HPOID:0006510	Chronic obstructive pulmonary disease	DOID:3083	chronic obstructive pulmonary disease	NA	NA	NA	NA	Chronic obstructive airway disease	NA	Research Support, N.I.H., Extramural	Research Support, Non-U.S. Gov't	Research Support, U.S. Gov't, Non-P.H.S.
2	13042709	rs13430556	T	C	rs13430556	23990791	3.82E-05	imputed, conditional on PI S and Z alleles in GWAS stage only	0.04	NA	1,392 European ancestry individuals	European(1392)	ALL(1392)	EUR(1392)	ALL(1392)	Serum alpha1-antitrypsin levels	HPOID:0006510	Chronic obstructive pulmonary disease	DOID:3083	chronic obstructive pulmonary disease	NA	NA	NA	NA	Chronic obstructive airway disease	NA	Research Support, N.I.H., Extramural	Research Support, Non-U.S. Gov't	Research Support, U.S. Gov't, Non-P.H.S.
2	13042823	rs13388631	G	C	rs13388631	23990791	3.56E-05	imputed, conditional on PI S and Z alleles in GWAS stage only	0.04	NA	1,392 European ancestry individuals	European(1392)	ALL(1392)	EUR(1392)	ALL(1392)	Serum alpha1-antitrypsin levels	HPOID:0006510	Chronic obstructive pulmonary disease	DOID:3083	chronic obstructive pulmonary disease	NA	NA	NA	NA	Chronic obstructive airway disease	NA	Research Support, N.I.H., Extramural	Research Support, Non-U.S. Gov't	Research Support, U.S. Gov't, Non-P.H.S.
2	13042870	rs10172921	G	A	rs10172921	23990791	3.30E-05	imputed, conditional on PI S and Z alleles in GWAS stage only	0.04	NA	1,392 European ancestry individuals	European(1392)	ALL(1392)	EUR(1392)	ALL(1392)	Serum alpha1-antitrypsin levels	HPOID:0006510	Chronic obstructive pulmonary disease	DOID:3083	chronic obstructive pulmonary disease	NA	NA	NA	NA	Chronic obstructive airway disease	NA	Research Support, N.I.H., Extramural	Research Support, Non-U.S. Gov't	Research Support, U.S. Gov't, Non-P.H.S.
2	13045563	rs13390247	T	C	rs13390247	23990791	4.20E-05	imputed, conditional on PI S and Z alleles in GWAS stage only	0.04	NA	1,392 European ancestry individuals	European(1392)	ALL(1392)	EUR(1392)	ALL(1392)	Serum alpha1-antitrypsin levels	HPOID:0006510	Chronic obstructive pulmonary disease	DOID:3083	chronic obstructive pulmonary disease	NA	NA	NA	NA	Chronic obstructive airway disease	NA	Research Support, N.I.H., Extramural	Research Support, Non-U.S. Gov't	Research Support, U.S. Gov't, Non-P.H.S.
2	13054564	rs13400830	A	G	rs13400830	23990791	7.83E-06	imputed, conditional on PI S and Z alleles in GWAS stage only	0.05	NA	1,392 European ancestry individuals	European(1392)	ALL(1392)	EUR(1392)	ALL(1392)	Serum alpha1-antitrypsin levels	HPOID:0006510	Chronic obstructive pulmonary disease	DOID:3083	chronic obstructive pulmonary disease	NA	NA	NA	NA	Chronic obstructive airway disease	NA	Research Support, N.I.H., Extramural	Research Support, Non-U.S. Gov't	Research Support, U.S. Gov't, Non-P.H.S.
2	13055358	rs16859504	G	A	rs16859504	23990791	8.38E-06	imputed, conditional on PI S and Z alleles in GWAS stage only	0.05	NA	1,392 European ancestry individuals	European(1392)	ALL(1392)	EUR(1392)	ALL(1392)	Serum alpha1-antitrypsin levels	HPOID:0006510	Chronic obstructive pulmonary disease	DOID:3083	chronic obstructive pulmonary disease	NA	NA	NA	NA	Chronic obstructive airway disease	NA	Research Support, N.I.H., Extramural	Research Support, Non-U.S. Gov't	Research Support, U.S. Gov't, Non-P.H.S.
2	15872327	rs2080799	T	C	rs2080799	19300482	6.74E-05	NA	NA	NA	823 cases; 810 controls	NOPOP(1633)	ALL(1633)	NOPOP(1633)	ALL(1633)	Chronic obstructive pulmonary disease	HPOID:0006510	Chronic obstructive pulmonary disease	DOID:3083	chronic obstructive pulmonary disease	D029424	Pulmonary Disease, Chronic Obstructive	EFOID:0000341	chronic obstructive pulmonary disease	Chronic obstructive airway disease	NA	Research Support, N.I.H., Extramural	Research Support, U.S. Gov't, P.H.S.	Research Support, Non-U.S. Gov't
2	15872385	rs2080798	T	C	rs2080798	19300482	1.63E-05	NA	NA	NA	823 cases; 810 controls	NOPOP(1633)	ALL(1633)	NOPOP(1633)	ALL(1633)	Chronic obstructive pulmonary disease	HPOID:0006510	Chronic obstructive pulmonary disease	DOID:3083	chronic obstructive pulmonary disease	D029424	Pulmonary Disease, Chronic Obstructive	EFOID:0000341	chronic obstructive pulmonary disease	Chronic obstructive airway disease	NA	Research Support, N.I.H., Extramural	Research Support, U.S. Gov't, P.H.S.	Research Support, Non-U.S. Gov't
2	22568713	rs7569716	A	T	rs7569716	24621683	1.00E-07	(AA)	NA	NA	5,812 European ancestry cases; 3,955 European ancestry controls; 821 African American cases; 1,749 African American controls	African American(2570)	European(9767)	ALL(12337)	AFR(2570)	EUR(9767)	ALL(12337)	Chronic obstructive pulmonary disease (moderate to severe)	HPOID:0006510	Chronic obstructive pulmonary disease	DOID:3083	chronic obstructive pulmonary disease	NA	NA	NA	NA	Chronic obstructive airway disease	NA	Research Support, N.I.H., Extramural
2	47022543	rs76351433	A	C	rs76351433	21685187	2.00E-07	Current CPD	1.45	NA	3,441 Caucasian ever-smokers with COPD	Caucasian(3441)	ALL(3441)	EUR(3441)	ALL(3441)	Chronic obstructive pulmonary disease	HPOID:0006510	Chronic obstructive pulmonary disease	DOID:3083	chronic obstructive pulmonary disease	D029424	Pulmonary Disease, Chronic Obstructive	EFOID:0000341	chronic obstructive pulmonary disease	Chronic obstructive airway disease	rs76351433-A	Randomized Controlled Trial	Multicenter Study	Research Support, N.I.H., Extramural
2	47942902	rs4588237	A	G	rs4588237	19300482	7.66E-05	NA	NA	NA	823 cases; 810 controls	NOPOP(1633)	ALL(1633)	NOPOP(1633)	ALL(1633)	Chronic obstructive pulmonary disease	HPOID:0006510	Chronic obstructive pulmonary disease	DOID:3083	chronic obstructive pulmonary disease	D029424	Pulmonary Disease, Chronic Obstructive	EFOID:0000341	chronic obstructive pulmonary disease	Chronic obstructive airway disease	NA	Research Support, N.I.H., Extramural	Research Support, U.S. Gov't, P.H.S.	Research Support, Non-U.S. Gov't
2	57107235	rs12479315	A	G	rs12479315	23990791	1.86E-05	imputed, conditional on PI S and Z alleles in GWAS stage only	0.03	NA	1,392 European ancestry individuals	European(1392)	ALL(1392)	EUR(1392)	ALL(1392)	Serum alpha1-antitrypsin levels	HPOID:0006510	Chronic obstructive pulmonary disease	DOID:3083	chronic obstructive pulmonary disease	NA	NA	NA	NA	Chronic obstructive airway disease	NA	Research Support, N.I.H., Extramural	Research Support, Non-U.S. Gov't	Research Support, U.S. Gov't, Non-P.H.S.
2	57110146	rs2216407	C	A	rs2216407	23990791	1.92E-05	imputed, conditional on PI S and Z alleles in GWAS stage only	0.03	NA	1,392 European ancestry individuals	European(1392)	ALL(1392)	EUR(1392)	ALL(1392)	Serum alpha1-antitrypsin levels	HPOID:0006510	Chronic obstructive pulmonary disease	DOID:3083	chronic obstructive pulmonary disease	NA	NA	NA	NA	Chronic obstructive airway disease	NA	Research Support, N.I.H., Extramural	Research Support, Non-U.S. Gov't	Research Support, U.S. Gov't, Non-P.H.S.
2	59605576	rs4432437	T	C	rs4432437	19300482	4.22E-05	NA	NA	NA	823 cases; 810 controls	NOPOP(1633)	ALL(1633)	NOPOP(1633)	ALL(1633)	Chronic obstructive pulmonary disease	HPOID:0006510	Chronic obstructive pulmonary disease	DOID:3083	chronic obstructive pulmonary disease	D029424	Pulmonary Disease, Chronic Obstructive	EFOID:0000341	chronic obstructive pulmonary disease	Chronic obstructive airway disease	NA	Research Support, N.I.H., Extramural	Research Support, U.S. Gov't, P.H.S.	Research Support, Non-U.S. Gov't
2	77666733	rs13395897	A	G	rs13395897	23990791	3.76E-05	imputed, conditional on PI S and Z alleles in GWAS stage only	0.06	NA	1,392 European ancestry individuals	European(1392)	ALL(1392)	EUR(1392)	ALL(1392)	Serum alpha1-antitrypsin levels	HPOID:0006510	Chronic obstructive pulmonary disease	DOID:3083	chronic obstructive pulmonary disease	NA	NA	NA	NA	Chronic obstructive airway disease	NA	Research Support, N.I.H., Extramural	Research Support, Non-U.S. Gov't	Research Support, U.S. Gov't, Non-P.H.S.
2	114022658	rs6542127	T	C	rs6542127	19300482	9.25E-05	NA	NA	NA	823 cases; 810 controls	NOPOP(1633)	ALL(1633)	NOPOP(1633)	ALL(1633)	Chronic obstructive pulmonary disease	HPOID:0006510	Chronic obstructive pulmonary disease	DOID:3083	chronic obstructive pulmonary disease	D029424	Pulmonary Disease, Chronic Obstructive	EFOID:0000341	chronic obstructive pulmonary disease	Chronic obstructive airway disease	NA	Research Support, N.I.H., Extramural	Research Support, U.S. Gov't, P.H.S.	Research Support, Non-U.S. Gov't
2	117946885	rs10179218	C	A	rs10179218	22837378	1.85E-08	NA	NA	NA	up to 3,368 European ancestry cases; up to 29,507 European ancestry controls	European(32875)	ALL(32875)	EUR(32875)	ALL(32875)	Airflow obstruction	HPOID:0006536	Obstructive lung disease	DOID:3083	chronic obstructive pulmonary disease	D000402	Airway Obstruction	EFOID:0003892	pulmonary function measurement	Chronic obstructive airway disease	NA	Research Support, N.I.H., Extramural	Meta-Analysis	Research Support, Non-U.S. Gov't
2	118876072	rs11673894	G	T	rs11673894	19300482	9.71E-05	NA	NA	NA	823 cases; 810 controls	NOPOP(1633)	ALL(1633)	NOPOP(1633)	ALL(1633)	Chronic obstructive pulmonary disease	HPOID:0006510	Chronic obstructive pulmonary disease	DOID:3083	chronic obstructive pulmonary disease	D029424	Pulmonary Disease, Chronic Obstructive	EFOID:0000341	chronic obstructive pulmonary disease	Chronic obstructive airway disease	NA	Research Support, N.I.H., Extramural	Research Support, U.S. Gov't, P.H.S.	Research Support, Non-U.S. Gov't
2	119536884	rs1551133	C	A	rs1551133	19300482	2.38E-05	NA	NA	NA	823 cases; 810 controls	NOPOP(1633)	ALL(1633)	NOPOP(1633)	ALL(1633)	Chronic obstructive pulmonary disease	HPOID:0006510	Chronic obstructive pulmonary disease	DOID:3083	chronic obstructive pulmonary disease	D029424	Pulmonary Disease, Chronic Obstructive	EFOID:0000341	chronic obstructive pulmonary disease	Chronic obstructive airway disease	NA	Research Support, N.I.H., Extramural	Research Support, U.S. Gov't, P.H.S.	Research Support, Non-U.S. Gov't
2	130468366	rs10928927	C	T	rs10928927	21685187	3.00E-07	Age at smoking initiation	17.54	NA	3,441 European ancestry ever-smokers with COPD	European(3441)	ALL(3441)	EUR(3441)	ALL(3441)	Chronic obstructive pulmonary disease	HPOID:0006510	Chronic obstructive pulmonary disease	DOID:3083	chronic obstructive pulmonary disease	D029424	Pulmonary Disease, Chronic Obstructive	EFOID:0000341	chronic obstructive pulmonary disease	Chronic obstructive airway disease	rs10928927-C	Randomized Controlled Trial	Multicenter Study	Research Support, N.I.H., Extramural
2	157452216	rs6706895	G	C	rs6706895	19300482	7.90E-05	NA	NA	NA	823 cases; 810 controls	NOPOP(1633)	ALL(1633)	NOPOP(1633)	ALL(1633)	Chronic obstructive pulmonary disease	HPOID:0006510	Chronic obstructive pulmonary disease	DOID:3083	chronic obstructive pulmonary disease	D029424	Pulmonary Disease, Chronic Obstructive	EFOID:0000341	chronic obstructive pulmonary disease	Chronic obstructive airway disease	NA	Research Support, N.I.H., Extramural	Research Support, U.S. Gov't, P.H.S.	Research Support, Non-U.S. Gov't
2	158791560	rs6720264	A	G	rs6720264	19300482	6.69E-05	NA	NA	NA	823 cases; 810 controls	NOPOP(1633)	ALL(1633)	NOPOP(1633)	ALL(1633)	Chronic obstructive pulmonary disease	HPOID:0006510	Chronic obstructive pulmonary disease	DOID:3083	chronic obstructive pulmonary disease	D029424	Pulmonary Disease, Chronic Obstructive	EFOID:0000341	chronic obstructive pulmonary disease	Chronic obstructive airway disease	NA	Research Support, N.I.H., Extramural	Research Support, U.S. Gov't, P.H.S.	Research Support, Non-U.S. Gov't
2	168824134	rs935381	C	T	rs935381	19300482	7.47E-05	NA	NA	NA	823 cases; 810 controls	NOPOP(1633)	ALL(1633)	NOPOP(1633)	ALL(1633)	Chronic obstructive pulmonary disease	HPOID:0006510	Chronic obstructive pulmonary disease	DOID:3083	chronic obstructive pulmonary disease	D029424	Pulmonary Disease, Chronic Obstructive	EFOID:0000341	chronic obstructive pulmonary disease	Chronic obstructive airway disease	NA	Research Support, N.I.H., Extramural	Research Support, U.S. Gov't, P.H.S.	Research Support, Non-U.S. Gov't
2	169869901	rs4148777	A	G	rs4148777	19300482	9.07E-05	NA	NA	NA	823 cases; 810 controls	NOPOP(1633)	ALL(1633)	NOPOP(1633)	ALL(1633)	Chronic obstructive pulmonary disease	HPOID:0006510	Chronic obstructive pulmonary disease	DOID:3083	chronic obstructive pulmonary disease	D029424	Pulmonary Disease, Chronic Obstructive	EFOID:0000341	chronic obstructive pulmonary disease	Chronic obstructive airway disease	NA	Research Support, N.I.H., Extramural	Research Support, U.S. Gov't, P.H.S.	Research Support, Non-U.S. Gov't
2	183057446	rs1432534	A	C	rs1432534	19300482	8.75E-05	NA	NA	NA	823 cases; 810 controls	NOPOP(1633)	ALL(1633)	NOPOP(1633)	ALL(1633)	Chronic obstructive pulmonary disease	HPOID:0006510	Chronic obstructive pulmonary disease	DOID:3083	chronic obstructive pulmonary disease	D029424	Pulmonary Disease, Chronic Obstructive	EFOID:0000341	chronic obstructive pulmonary disease	Chronic obstructive airway disease	NA	Research Support, N.I.H., Extramural	Research Support, U.S. Gov't, P.H.S.	Research Support, Non-U.S. Gov't
2	196531667	rs41416845	T	C	rs41416845	22837378	1.65E-08	NA	NA	NA	up to 3,368 European ancestry cases; up to 29,507 European ancestry controls	European(32875)	ALL(32875)	EUR(32875)	ALL(32875)	Airflow obstruction	HPOID:0006536	Obstructive lung disease	DOID:3083	chronic obstructive pulmonary disease	D000402	Airway Obstruction	EFOID:0003892	pulmonary function measurement	Chronic obstructive airway disease	NA	Research Support, N.I.H., Extramural	Meta-Analysis	Research Support, Non-U.S. Gov't
2	213081443	rs1402769	T	G	rs1402769	19300482	4.46E-05	NA	NA	NA	823 cases; 810 controls	NOPOP(1633)	ALL(1633)	NOPOP(1633)	ALL(1633)	Chronic obstructive pulmonary disease	HPOID:0006510	Chronic obstructive pulmonary disease	DOID:3083	chronic obstructive pulmonary disease	D029424	Pulmonary Disease, Chronic Obstructive	EFOID:0000341	chronic obstructive pulmonary disease	Chronic obstructive airway disease	NA	Research Support, N.I.H., Extramural	Research Support, U.S. Gov't, P.H.S.	Research Support, Non-U.S. Gov't
2	237521842	rs7607316	C	A	rs7607316	22837378	3.00E-06	Never smoker	1.29	NA	up to 3,368 European ancestry cases; up to 29,507 European ancestry controls	European(32875)	ALL(32875)	EUR(32875)	ALL(32875)	Airflow obstruction	HPOID:0006536	Obstructive lung disease	DOID:3083	chronic obstructive pulmonary disease	D000402	Airway Obstruction	EFOID:0003892	pulmonary function measurement	Chronic obstructive airway disease	rs7607316-A	Research Support, N.I.H., Extramural	Meta-Analysis	Research Support, Non-U.S. Gov't
3	3096927	rs163574	A	G	rs163574	19300482	6.77E-05	NA	NA	NA	823 cases; 810 controls	NOPOP(1633)	ALL(1633)	NOPOP(1633)	ALL(1633)	Chronic obstructive pulmonary disease	HPOID:0006510	Chronic obstructive pulmonary disease	DOID:3083	chronic obstructive pulmonary disease	D029424	Pulmonary Disease, Chronic Obstructive	EFOID:0000341	chronic obstructive pulmonary disease	Chronic obstructive airway disease	NA	Research Support, N.I.H., Extramural	Research Support, U.S. Gov't, P.H.S.	Research Support, Non-U.S. Gov't
3	4633492	rs2322734	C	A	rs2322734	22837378	8.00E-06	FEV1 65%	1.45	NA	up to 3,368 European ancestry cases; up to 29,507 European ancestry controls	European(32875)	ALL(32875)	EUR(32875)	ALL(32875)	Airflow obstruction	HPOID:0006536	Obstructive lung disease	DOID:3083	chronic obstructive pulmonary disease	D000402	Airway Obstruction	EFOID:0003892	pulmonary function measurement	Chronic obstructive airway disease	NA	Research Support, N.I.H., Extramural	Meta-Analysis	Research Support, Non-U.S. Gov't
3	10632679	rs4234503	C	T	rs4234503	22837378	1.95E-08	NA	NA	NA	up to 3,368 European ancestry cases; up to 29,507 European ancestry controls	European(32875)	ALL(32875)	EUR(32875)	ALL(32875)	Airflow obstruction	HPOID:0006536	Obstructive lung disease	DOID:3083	chronic obstructive pulmonary disease	D000402	Airway Obstruction	EFOID:0003892	pulmonary function measurement	Chronic obstructive airway disease	NA	Research Support, N.I.H., Extramural	Meta-Analysis	Research Support, Non-U.S. Gov't
3	13857969	rs1124480	T	C	rs1124480	23144326	9.00E-06	IL6	NA	NA	Up to 1,951 European ancestry smokers	European(1951)	ALL(1951)	EUR(1951)	ALL(1951)	Chronic obstructive pulmonary disease-related biomarkers	HPOID:0006510	Chronic obstructive pulmonary disease	DOID:3083	chronic obstructive pulmonary disease	D029424	Pulmonary Disease, Chronic Obstructive	EFOID:0005080	surfactant protein D measurement	Chronic obstructive airway disease	rs1124480-C	Clinical Trial	Research Support, N.I.H., Extramural	Research Support, Non-U.S. Gov't
3	25538317	rs1997352	C	A,T	rs1997352	22837378	9.00E-07	All	1.19	NA	up to 3,368 European ancestry cases; up to 29,507 European ancestry controls	European(32875)	ALL(32875)	EUR(32875)	ALL(32875)	Airflow obstruction	HPOID:0006536	Obstructive lung disease	DOID:3083	chronic obstructive pulmonary disease	D000402	Airway Obstruction	EFOID:0003892	pulmonary function measurement	Chronic obstructive airway disease	NA	Research Support, N.I.H., Extramural	Meta-Analysis	Research Support, Non-U.S. Gov't
3	43909699	rs6790122	T	A	rs6790122	19300482	2.93E-05	NA	NA	NA	823 cases; 810 controls	NOPOP(1633)	ALL(1633)	NOPOP(1633)	ALL(1633)	Chronic obstructive pulmonary disease	HPOID:0006510	Chronic obstructive pulmonary disease	DOID:3083	chronic obstructive pulmonary disease	D029424	Pulmonary Disease, Chronic Obstructive	EFOID:0000341	chronic obstructive pulmonary disease	Chronic obstructive airway disease	NA	Research Support, N.I.H., Extramural	Research Support, U.S. Gov't, P.H.S.	Research Support, Non-U.S. Gov't
3	55969858	rs4974153	G	T	rs4974153	19300482	9.55E-05	NA	NA	NA	823 cases; 810 controls	NOPOP(1633)	ALL(1633)	NOPOP(1633)	ALL(1633)	Chronic obstructive pulmonary disease	HPOID:0006510	Chronic obstructive pulmonary disease	DOID:3083	chronic obstructive pulmonary disease	D029424	Pulmonary Disease, Chronic Obstructive	EFOID:0000341	chronic obstructive pulmonary disease	Chronic obstructive airway disease	NA	Research Support, N.I.H., Extramural	Research Support, U.S. Gov't, P.H.S.	Research Support, Non-U.S. Gov't
3	55993656	rs12495172	G	A	rs12495172	19300482	2.79E-05	NA	NA	NA	823 cases; 810 controls	NOPOP(1633)	ALL(1633)	NOPOP(1633)	ALL(1633)	Chronic obstructive pulmonary disease	HPOID:0006510	Chronic obstructive pulmonary disease	DOID:3083	chronic obstructive pulmonary disease	D029424	Pulmonary Disease, Chronic Obstructive	EFOID:0000341	chronic obstructive pulmonary disease	Chronic obstructive airway disease	NA	Research Support, N.I.H., Extramural	Research Support, U.S. Gov't, P.H.S.	Research Support, Non-U.S. Gov't
3	56054077	rs13061634	T	C	rs13061634	19300482	2.76E-05	NA	NA	NA	823 cases; 810 controls	NOPOP(1633)	ALL(1633)	NOPOP(1633)	ALL(1633)	Chronic obstructive pulmonary disease	HPOID:0006510	Chronic obstructive pulmonary disease	DOID:3083	chronic obstructive pulmonary disease	D029424	Pulmonary Disease, Chronic Obstructive	EFOID:0000341	chronic obstructive pulmonary disease	Chronic obstructive airway disease	NA	Research Support, N.I.H., Extramural	Research Support, U.S. Gov't, P.H.S.	Research Support, Non-U.S. Gov't
3	56070758	rs9862661	A	C	rs9862661	19300482	1.57E-05	NA	NA	NA	823 cases; 810 controls	NOPOP(1633)	ALL(1633)	NOPOP(1633)	ALL(1633)	Chronic obstructive pulmonary disease	HPOID:0006510	Chronic obstructive pulmonary disease	DOID:3083	chronic obstructive pulmonary disease	D029424	Pulmonary Disease, Chronic Obstructive	EFOID:0000341	chronic obstructive pulmonary disease	Chronic obstructive airway disease	NA	Research Support, N.I.H., Extramural	Research Support, U.S. Gov't, P.H.S.	Research Support, Non-U.S. Gov't
3	71201454	rs7653672	G	A	rs7653672	23990791	3.45E-05	imputed, conditional on PI S and Z alleles in GWAS stage only	0.03	NA	1,392 European ancestry individuals	European(1392)	ALL(1392)	EUR(1392)	ALL(1392)	Serum alpha1-antitrypsin levels	HPOID:0006510	Chronic obstructive pulmonary disease	DOID:3083	chronic obstructive pulmonary disease	NA	NA	NA	NA	Chronic obstructive airway disease	NA	Research Support, N.I.H., Extramural	Research Support, Non-U.S. Gov't	Research Support, U.S. Gov't, Non-P.H.S.
3	71202106	rs11923661	A	C	rs11923661	23990791	2.34E-05	imputed, conditional on PI S and Z alleles in GWAS stage only	0.03	NA	1,392 European ancestry individuals	European(1392)	ALL(1392)	EUR(1392)	ALL(1392)	Serum alpha1-antitrypsin levels	HPOID:0006510	Chronic obstructive pulmonary disease	DOID:3083	chronic obstructive pulmonary disease	NA	NA	NA	NA	Chronic obstructive airway disease	NA	Research Support, N.I.H., Extramural	Research Support, Non-U.S. Gov't	Research Support, U.S. Gov't, Non-P.H.S.
3	71204263	rs1522178	C	G	rs1522178	23990791	2.63E-05	imputed, conditional on PI S and Z alleles in GWAS stage only	0.03	NA	1,392 European ancestry individuals	European(1392)	ALL(1392)	EUR(1392)	ALL(1392)	Serum alpha1-antitrypsin levels	HPOID:0006510	Chronic obstructive pulmonary disease	DOID:3083	chronic obstructive pulmonary disease	NA	NA	NA	NA	Chronic obstructive airway disease	NA	Research Support, N.I.H., Extramural	Research Support, Non-U.S. Gov't	Research Support, U.S. Gov't, Non-P.H.S.
3	111201785	rs76884941	T	G	rs76884941	21685187	1.00E-07	Current CPD	2.11	NA	3,441 Caucasian ever-smokers with COPD	Caucasian(3441)	ALL(3441)	EUR(3441)	ALL(3441)	Chronic obstructive pulmonary disease	HPOID:0006510	Chronic obstructive pulmonary disease	DOID:3083	chronic obstructive pulmonary disease	D029424	Pulmonary Disease, Chronic Obstructive	EFOID:0000341	chronic obstructive pulmonary disease	Chronic obstructive airway disease	rs76884941-G	Randomized Controlled Trial	Multicenter Study	Research Support, N.I.H., Extramural
3	111233239	rs56238310	C	A,T	rs56238310	21685187	1.00E-07	Current CPD	2.11	NA	3,441 Caucasian ever-smokers with COPD	Caucasian(3441)	ALL(3441)	EUR(3441)	ALL(3441)	Chronic obstructive pulmonary disease	HPOID:0006510	Chronic obstructive pulmonary disease	DOID:3083	chronic obstructive pulmonary disease	D029424	Pulmonary Disease, Chronic Obstructive	EFOID:0000341	chronic obstructive pulmonary disease	Chronic obstructive airway disease	rs56238310-A	Randomized Controlled Trial	Multicenter Study	Research Support, N.I.H., Extramural
3	123699823	rs17310770	A	C	rs17310770	19300482	6.65E-05	NA	NA	NA	823 cases; 810 controls	NOPOP(1633)	ALL(1633)	NOPOP(1633)	ALL(1633)	Chronic obstructive pulmonary disease	HPOID:0006510	Chronic obstructive pulmonary disease	DOID:3083	chronic obstructive pulmonary disease	D029424	Pulmonary Disease, Chronic Obstructive	EFOID:0000341	chronic obstructive pulmonary disease	Chronic obstructive airway disease	NA	Research Support, N.I.H., Extramural	Research Support, U.S. Gov't, P.H.S.	Research Support, Non-U.S. Gov't
3	135441431	rs11719713	C	A	rs11719713	19300482	7.22E-05	NA	NA	NA	823 cases; 810 controls	NOPOP(1633)	ALL(1633)	NOPOP(1633)	ALL(1633)	Chronic obstructive pulmonary disease	HPOID:0006510	Chronic obstructive pulmonary disease	DOID:3083	chronic obstructive pulmonary disease	D029424	Pulmonary Disease, Chronic Obstructive	EFOID:0000341	chronic obstructive pulmonary disease	Chronic obstructive airway disease	NA	Research Support, N.I.H., Extramural	Research Support, U.S. Gov't, P.H.S.	Research Support, Non-U.S. Gov't
3	149252824	rs16861952	C	A	rs16861952	23990791	8.28E-06	imputed, conditional on PI S and Z alleles in GWAS stage only	0.05	NA	1,392 European ancestry individuals	European(1392)	ALL(1392)	EUR(1392)	ALL(1392)	Serum alpha1-antitrypsin levels	HPOID:0006510	Chronic obstructive pulmonary disease	DOID:3083	chronic obstructive pulmonary disease	NA	NA	NA	NA	Chronic obstructive airway disease	NA	Research Support, N.I.H., Extramural	Research Support, Non-U.S. Gov't	Research Support, U.S. Gov't, Non-P.H.S.
3	149754956	rs16862394	C	T	rs16862394	22837378	5.10E-09	NA	NA	NA	up to 3,368 European ancestry cases; up to 29,507 European ancestry controls	European(32875)	ALL(32875)	EUR(32875)	ALL(32875)	Airflow obstruction	HPOID:0006536	Obstructive lung disease	DOID:3083	chronic obstructive pulmonary disease	D000402	Airway Obstruction	EFOID:0003892	pulmonary function measurement	Chronic obstructive airway disease	NA	Research Support, N.I.H., Extramural	Meta-Analysis	Research Support, Non-U.S. Gov't
3	158320880	rs2304408	G	C	rs2304408	23990791	1.99E-05	imputed, conditional on PI S and Z alleles in GWAS stage only	0.03	NA	1,392 European ancestry individuals	European(1392)	ALL(1392)	EUR(1392)	ALL(1392)	Serum alpha1-antitrypsin levels	HPOID:0006510	Chronic obstructive pulmonary disease	DOID:3083	chronic obstructive pulmonary disease	NA	NA	NA	NA	Chronic obstructive airway disease	NA	Research Support, N.I.H., Extramural	Research Support, Non-U.S. Gov't	Research Support, U.S. Gov't, Non-P.H.S.
3	158335409	rs7624771	C	T	rs7624771	23990791	2.28E-05	imputed, conditional on PI S and Z alleles in GWAS stage only	0.03	NA	1,392 European ancestry individuals	European(1392)	ALL(1392)	EUR(1392)	ALL(1392)	Serum alpha1-antitrypsin levels	HPOID:0006510	Chronic obstructive pulmonary disease	DOID:3083	chronic obstructive pulmonary disease	NA	NA	NA	NA	Chronic obstructive airway disease	NA	Research Support, N.I.H., Extramural	Research Support, Non-U.S. Gov't	Research Support, U.S. Gov't, Non-P.H.S.
3	158360592	rs6776901	T	C	rs6776901	23990791	2.55E-05	imputed, conditional on PI S and Z alleles in GWAS stage only	0.03	NA	1,392 European ancestry individuals	European(1392)	ALL(1392)	EUR(1392)	ALL(1392)	Serum alpha1-antitrypsin levels	HPOID:0006510	Chronic obstructive pulmonary disease	DOID:3083	chronic obstructive pulmonary disease	NA	NA	NA	NA	Chronic obstructive airway disease	NA	Research Support, N.I.H., Extramural	Research Support, Non-U.S. Gov't	Research Support, U.S. Gov't, Non-P.H.S.
3	158360944	rs6777231	T	C	rs6777231	23990791	2.56E-05	imputed, conditional on PI S and Z alleles in GWAS stage only	0.03	NA	1,392 European ancestry individuals	European(1392)	ALL(1392)	EUR(1392)	ALL(1392)	Serum alpha1-antitrypsin levels	HPOID:0006510	Chronic obstructive pulmonary disease	DOID:3083	chronic obstructive pulmonary disease	NA	NA	NA	NA	Chronic obstructive airway disease	NA	Research Support, N.I.H., Extramural	Research Support, Non-U.S. Gov't	Research Support, U.S. Gov't, Non-P.H.S.
3	158376354	rs17697458	C	G	rs17697458	23990791	2.62E-05	imputed, conditional on PI S and Z alleles in GWAS stage only	0.03	NA	1,392 European ancestry individuals	European(1392)	ALL(1392)	EUR(1392)	ALL(1392)	Serum alpha1-antitrypsin levels	HPOID:0006510	Chronic obstructive pulmonary disease	DOID:3083	chronic obstructive pulmonary disease	NA	NA	NA	NA	Chronic obstructive airway disease	NA	Research Support, N.I.H., Extramural	Research Support, Non-U.S. Gov't	Research Support, U.S. Gov't, Non-P.H.S.
3	158389860	rs17630607	C	T	rs17630607	23990791	2.67E-05	imputed, conditional on PI S and Z alleles in GWAS stage only	0.03	NA	1,392 European ancestry individuals	European(1392)	ALL(1392)	EUR(1392)	ALL(1392)	Serum alpha1-antitrypsin levels	HPOID:0006510	Chronic obstructive pulmonary disease	DOID:3083	chronic obstructive pulmonary disease	NA	NA	NA	NA	Chronic obstructive airway disease	NA	Research Support, N.I.H., Extramural	Research Support, Non-U.S. Gov't	Research Support, U.S. Gov't, Non-P.H.S.
3	158405873	rs17698494	G	A	rs17698494	23990791	2.57E-05	imputed, conditional on PI S and Z alleles in GWAS stage only	0.03	NA	1,392 European ancestry individuals	European(1392)	ALL(1392)	EUR(1392)	ALL(1392)	Serum alpha1-antitrypsin levels	HPOID:0006510	Chronic obstructive pulmonary disease	DOID:3083	chronic obstructive pulmonary disease	NA	NA	NA	NA	Chronic obstructive airway disease	NA	Research Support, N.I.H., Extramural	Research Support, Non-U.S. Gov't	Research Support, U.S. Gov't, Non-P.H.S.
3	158411704	rs17698754	G	A	rs17698754	23990791	2.46E-05	imputed, conditional on PI S and Z alleles in GWAS stage only	0.03	NA	1,392 European ancestry individuals	European(1392)	ALL(1392)	EUR(1392)	ALL(1392)	Serum alpha1-antitrypsin levels	HPOID:0006510	Chronic obstructive pulmonary disease	DOID:3083	chronic obstructive pulmonary disease	NA	NA	NA	NA	Chronic obstructive airway disease	NA	Research Support, N.I.H., Extramural	Research Support, Non-U.S. Gov't	Research Support, U.S. Gov't, Non-P.H.S.
3	158411704	rs539104674	G	GC	rs17698754	23990791	2.46E-05	imputed, conditional on PI S and Z alleles in GWAS stage only	0.03	NA	1,392 European ancestry individuals	European(1392)	ALL(1392)	EUR(1392)	ALL(1392)	Serum alpha1-antitrypsin levels	HPOID:0006510	Chronic obstructive pulmonary disease	DOID:3083	chronic obstructive pulmonary disease	NA	NA	NA	NA	Chronic obstructive airway disease	NA	Research Support, N.I.H., Extramural	Research Support, Non-U.S. Gov't	Research Support, U.S. Gov't, Non-P.H.S.
3	158415840	rs3867391	T	G	rs3867391	23990791	2.44E-05	imputed, conditional on PI S and Z alleles in GWAS stage only	0.03	NA	1,392 European ancestry individuals	European(1392)	ALL(1392)	EUR(1392)	ALL(1392)	Serum alpha1-antitrypsin levels	HPOID:0006510	Chronic obstructive pulmonary disease	DOID:3083	chronic obstructive pulmonary disease	NA	NA	NA	NA	Chronic obstructive airway disease	NA	Research Support, N.I.H., Extramural	Research Support, Non-U.S. Gov't	Research Support, U.S. Gov't, Non-P.H.S.
3	158419789	rs17699103	A	G	rs17699103	23990791	2.41E-05	imputed, conditional on PI S and Z alleles in GWAS stage only	0.03	NA	1,392 European ancestry individuals	European(1392)	ALL(1392)	EUR(1392)	ALL(1392)	Serum alpha1-antitrypsin levels	HPOID:0006510	Chronic obstructive pulmonary disease	DOID:3083	chronic obstructive pulmonary disease	NA	NA	NA	NA	Chronic obstructive airway disease	NA	Research Support, N.I.H., Extramural	Research Support, Non-U.S. Gov't	Research Support, U.S. Gov't, Non-P.H.S.
3	158420369	rs7610009	C	A	rs7610009	23990791	2.41E-05	imputed, conditional on PI S and Z alleles in GWAS stage only	0.03	NA	1,392 European ancestry individuals	European(1392)	ALL(1392)	EUR(1392)	ALL(1392)	Serum alpha1-antitrypsin levels	HPOID:0006510	Chronic obstructive pulmonary disease	DOID:3083	chronic obstructive pulmonary disease	NA	NA	NA	NA	Chronic obstructive airway disease	NA	Research Support, N.I.H., Extramural	Research Support, Non-U.S. Gov't	Research Support, U.S. Gov't, Non-P.H.S.
3	158424561	rs17699324	T	C	rs17699324	23990791	2.40E-05	imputed, conditional on PI S and Z alleles in GWAS stage only	0.03	NA	1,392 European ancestry individuals	European(1392)	ALL(1392)	EUR(1392)	ALL(1392)	Serum alpha1-antitrypsin levels	HPOID:0006510	Chronic obstructive pulmonary disease	DOID:3083	chronic obstructive pulmonary disease	NA	NA	NA	NA	Chronic obstructive airway disease	NA	Research Support, N.I.H., Extramural	Research Support, Non-U.S. Gov't	Research Support, U.S. Gov't, Non-P.H.S.
3	158457914	rs12489730	T	G	rs12489730	23990791	3.94E-05	imputed, conditional on PI S and Z alleles in GWAS stage only	0.03	NA	1,392 European ancestry individuals	European(1392)	ALL(1392)	EUR(1392)	ALL(1392)	Serum alpha1-antitrypsin levels	HPOID:0006510	Chronic obstructive pulmonary disease	DOID:3083	chronic obstructive pulmonary disease	NA	NA	NA	NA	Chronic obstructive airway disease	NA	Research Support, N.I.H., Extramural	Research Support, Non-U.S. Gov't	Research Support, U.S. Gov't, Non-P.H.S.
3	158484933	rs17700475	A	G	rs17700475	23990791	1.25E-06	imputed, conditional on PI S and Z alleles in GWAS stage only	0.04	NA	1,392 European ancestry individuals	European(1392)	ALL(1392)	EUR(1392)	ALL(1392)	Serum alpha1-antitrypsin levels	HPOID:0006510	Chronic obstructive pulmonary disease	DOID:3083	chronic obstructive pulmonary disease	NA	NA	NA	NA	Chronic obstructive airway disease	NA	Research Support, N.I.H., Extramural	Research Support, Non-U.S. Gov't	Research Support, U.S. Gov't, Non-P.H.S.
3	158485260	rs17643860	G	A	rs17643860	23990791	1.24E-06	imputed, conditional on PI S and Z alleles in GWAS stage only	0.04	NA	1,392 European ancestry individuals	European(1392)	ALL(1392)	EUR(1392)	ALL(1392)	Serum alpha1-antitrypsin levels	HPOID:0006510	Chronic obstructive pulmonary disease	DOID:3083	chronic obstructive pulmonary disease	NA	NA	NA	NA	Chronic obstructive airway disease	NA	Research Support, N.I.H., Extramural	Research Support, Non-U.S. Gov't	Research Support, U.S. Gov't, Non-P.H.S.
3	158485739	rs17643917	A	G	rs17643917	23990791	1.23E-06	imputed, conditional on PI S and Z alleles in GWAS stage only	0.04	NA	1,392 European ancestry individuals	European(1392)	ALL(1392)	EUR(1392)	ALL(1392)	Serum alpha1-antitrypsin levels	HPOID:0006510	Chronic obstructive pulmonary disease	DOID:3083	chronic obstructive pulmonary disease	NA	NA	NA	NA	Chronic obstructive airway disease	NA	Research Support, N.I.H., Extramural	Research Support, Non-U.S. Gov't	Research Support, U.S. Gov't, Non-P.H.S.
3	158486700	rs3863076	A	G	rs3863076	23990791	1.69E-06	imputed, conditional on PI S and Z alleles in GWAS stage only	0.04	NA	1,392 European ancestry individuals	European(1392)	ALL(1392)	EUR(1392)	ALL(1392)	Serum alpha1-antitrypsin levels	HPOID:0006510	Chronic obstructive pulmonary disease	DOID:3083	chronic obstructive pulmonary disease	NA	NA	NA	NA	Chronic obstructive airway disease	NA	Research Support, N.I.H., Extramural	Research Support, Non-U.S. Gov't	Research Support, U.S. Gov't, Non-P.H.S.
3	158489641	rs1560418	A	G	rs1560418	23990791	1.11E-07	imputed, conditional on PI S and Z alleles in GWAS stage only	0.04	NA	1,392 European ancestry individuals	European(1392)	ALL(1392)	EUR(1392)	ALL(1392)	Serum alpha1-antitrypsin levels	HPOID:0006510	Chronic obstructive pulmonary disease	DOID:3083	chronic obstructive pulmonary disease	NA	NA	NA	NA	Chronic obstructive airway disease	NA	Research Support, N.I.H., Extramural	Research Support, Non-U.S. Gov't	Research Support, U.S. Gov't, Non-P.H.S.
3	158489782	rs1560417	G	A	rs1560417	23990791	1.11E-07	imputed, conditional on PI S and Z alleles in GWAS stage only	0.04	NA	1,392 European ancestry individuals	European(1392)	ALL(1392)	EUR(1392)	ALL(1392)	Serum alpha1-antitrypsin levels	HPOID:0006510	Chronic obstructive pulmonary disease	DOID:3083	chronic obstructive pulmonary disease	NA	NA	NA	NA	Chronic obstructive airway disease	NA	Research Support, N.I.H., Extramural	Research Support, Non-U.S. Gov't	Research Support, U.S. Gov't, Non-P.H.S.
3	158491377	rs2566347	C	A	rs2566347	23990791	7.88E-08	imputed, conditional on PI S and Z alleles in GWAS stage only	0.04	NA	1,392 European ancestry individuals	European(1392)	ALL(1392)	EUR(1392)	ALL(1392)	Serum alpha1-antitrypsin levels	HPOID:0006510	Chronic obstructive pulmonary disease	DOID:3083	chronic obstructive pulmonary disease	NA	NA	NA	NA	Chronic obstructive airway disease	NA	Research Support, N.I.H., Extramural	Research Support, Non-U.S. Gov't	Research Support, U.S. Gov't, Non-P.H.S.
3	158500559	rs6761989	C	T	rs6761989	23990791	1.14E-06	imputed, conditional on PI S and Z alleles in GWAS stage only	0.04	NA	1,392 European ancestry individuals	European(1392)	ALL(1392)	EUR(1392)	ALL(1392)	Serum alpha1-antitrypsin levels	HPOID:0006510	Chronic obstructive pulmonary disease	DOID:3083	chronic obstructive pulmonary disease	NA	NA	NA	NA	Chronic obstructive airway disease	NA	Research Support, N.I.H., Extramural	Research Support, Non-U.S. Gov't	Research Support, U.S. Gov't, Non-P.H.S.
3	158505003	rs1430414	G	T	rs1430414	23990791	9.26E-07	imputed, conditional on PI S and Z alleles in GWAS stage only	0.04	NA	1,392 European ancestry individuals	European(1392)	ALL(1392)	EUR(1392)	ALL(1392)	Serum alpha1-antitrypsin levels	HPOID:0006510	Chronic obstructive pulmonary disease	DOID:3083	chronic obstructive pulmonary disease	NA	NA	NA	NA	Chronic obstructive airway disease	NA	Research Support, N.I.H., Extramural	Research Support, Non-U.S. Gov't	Research Support, U.S. Gov't, Non-P.H.S.
3	158510674	rs7624420	C	A	rs7624420	23990791	4.43E-05	imputed, conditional on PI S and Z alleles in GWAS stage only	0.04	NA	1,392 European ancestry individuals	European(1392)	ALL(1392)	EUR(1392)	ALL(1392)	Serum alpha1-antitrypsin levels	HPOID:0006510	Chronic obstructive pulmonary disease	DOID:3083	chronic obstructive pulmonary disease	NA	NA	NA	NA	Chronic obstructive airway disease	NA	Research Support, N.I.H., Extramural	Research Support, Non-U.S. Gov't	Research Support, U.S. Gov't, Non-P.H.S.
3	171631672	rs12485367	C	G	rs12485367	22837378	1.53E-09	NA	NA	NA	up to 3,368 European ancestry cases; up to 29,507 European ancestry controls	European(32875)	ALL(32875)	EUR(32875)	ALL(32875)	Airflow obstruction	HPOID:0006536	Obstructive lung disease	DOID:3083	chronic obstructive pulmonary disease	D000402	Airway Obstruction	EFOID:0003892	pulmonary function measurement	Chronic obstructive airway disease	NA	Research Support, N.I.H., Extramural	Meta-Analysis	Research Support, Non-U.S. Gov't
3	185141857	rs7629245	C	T	rs7629245	22837378	9.00E-06	Smoker	1.22	NA	up to 3,368 European ancestry cases; up to 29,507 European ancestry controls	European(32875)	ALL(32875)	EUR(32875)	ALL(32875)	Airflow obstruction	HPOID:0006536	Obstructive lung disease	DOID:3083	chronic obstructive pulmonary disease	D000402	Airway Obstruction	EFOID:0003892	pulmonary function measurement	Chronic obstructive airway disease	rs7629245-T	Research Support, N.I.H., Extramural	Meta-Analysis	Research Support, Non-U.S. Gov't
4	24444785	rs6823107	C	T	rs6823107	19300482	3.62E-05	NA	NA	NA	823 cases; 810 controls	NOPOP(1633)	ALL(1633)	NOPOP(1633)	ALL(1633)	Chronic obstructive pulmonary disease	HPOID:0006510	Chronic obstructive pulmonary disease	DOID:3083	chronic obstructive pulmonary disease	D029424	Pulmonary Disease, Chronic Obstructive	EFOID:0000341	chronic obstructive pulmonary disease	Chronic obstructive airway disease	NA	Research Support, N.I.H., Extramural	Research Support, U.S. Gov't, P.H.S.	Research Support, Non-U.S. Gov't
4	24515631	rs7698250	C	T	rs7698250	24383474	2.00E-10	(Chinese)	0.46	[0.32-0.61] unit increase	2,587 European ancestry individuals; 2,510 African American individuals; 2,113 Hispanic individuals; 704 Chinese ancestry individuals	Chinese(704)	African American(2510)	European(2587)	Hispanic(2113)	ALL(7914)	ASN(704)	HIS(2113)	AFR(2510)	EUR(2587)	ALL(7914)	Pulmonary emphysema	HPOID:0006510	Chronic obstructive pulmonary disease	DOID:9675	pulmonary emphysema	NA	NA	NA
4	57334112	rs12505749	C	G	rs12505749	22837378	5.00E-06	All	1.27	NA	up to 3,368 European ancestry cases; up to 29,507 European ancestry controls	European(32875)	ALL(32875)	EUR(32875)	ALL(32875)	Airflow obstruction	HPOID:0006536	Obstructive lung disease	DOID:3083	chronic obstructive pulmonary disease	D000402	Airway Obstruction	EFOID:0003892	pulmonary function measurement	Chronic obstructive airway disease	NA	Research Support, N.I.H., Extramural	Meta-Analysis	Research Support, Non-U.S. Gov't
4	87362834	rs4488910	T	C	rs4488910	22837378	1.24E-09	NA	NA	NA	up to 3,368 European ancestry cases; up to 29,507 European ancestry controls	European(32875)	ALL(32875)	EUR(32875)	ALL(32875)	Airflow obstruction	HPOID:0006536	Obstructive lung disease	DOID:3083	chronic obstructive pulmonary disease	D000402	Airway Obstruction	EFOID:0003892	pulmonary function measurement	Chronic obstructive airway disease	NA	Research Support, N.I.H., Extramural	Meta-Analysis	Research Support, Non-U.S. Gov't
4	88807246	rs10004908	G	A	rs10004908	22837378	3.67E-10	NA	NA	NA	up to 3,368 European ancestry cases; up to 29,507 European ancestry controls	European(32875)	ALL(32875)	EUR(32875)	ALL(32875)	Airflow obstruction	HPOID:0006536	Obstructive lung disease	DOID:3083	chronic obstructive pulmonary disease	D000402	Airway Obstruction	EFOID:0003892	pulmonary function measurement	Chronic obstructive airway disease	NA	Research Support, N.I.H., Extramural	Meta-Analysis	Research Support, Non-U.S. Gov't
4	89866713	rs4416442	T	C	rs4416442	24621683	1.00E-14	NA	1.28	[1.20-1.36]	5,812 European ancestry cases; 3,955 European ancestry controls; 821 African American cases; 1,749 African American controls	African American(2570)	European(9767)	ALL(12337)	AFR(2570)	EUR(9767)	ALL(12337)	Chronic obstructive pulmonary disease (moderate to severe)	HPOID:0006510	Chronic obstructive pulmonary disease	DOID:3083	chronic obstructive pulmonary disease	NA	NA	NA	NA	Chronic obstructive airway disease	rs4416442-C	Research Support, N.I.H., Extramural
4	89866713	rs4416442	T	C	rs4416442	24621683	9.00E-15	NA	1.36	[1.26-1.47]	3,145 European ancestry cases; 3,955 European ancestry controls; 352 African American cases; 1,749 African American controls	African American(2101)	European(7100)	ALL(9201)	AFR(2101)	EUR(7100)	ALL(9201)	Chronic obstructive pulmonary disease (severe)	HPOID:0006510	Chronic obstructive pulmonary disease	DOID:3083	chronic obstructive pulmonary disease	NA	NA	NA	NA	Chronic obstructive airway disease	rs4416442-C	Research Support, N.I.H., Extramural
4	89869332	rs2869967	T	C	rs2869967	20173748	1.80E-07	NA	NA	NA	2,940 white cases; 1,380 white controls	NOPOP(4320)	ALL(4320)	NOPOP(4320)	ALL(4320)	Chronic obstructive pulmonary disease	HPOID:0006510	Chronic obstructive pulmonary disease	DOID:3083	chronic obstructive pulmonary disease	D029424	Pulmonary Disease, Chronic Obstructive	EFOID:0000341	chronic obstructive pulmonary disease	Chronic obstructive airway disease	NA	Research Support, N.I.H., Extramural	Research Support, Non-U.S. Gov't	Research Support, U.S. Gov't, Non-P.H.S.
4	89869332	rs2869967	T	C	rs2869967	21921092	1.41E-06	Chronic obstructive pulmonary disease (COPD)	NA	NA	58 Costa Rica descent cases; 57 Costa Rica descent controls	Costa Rica(115)	ALL(115)	HIS(115)	ALL(115)	chronic obstructive pulmonary disease	HPOID:0006510	Chronic obstructive pulmonary disease	DOID:3083	chronic obstructive pulmonary disease	D029424	Pulmonary Disease, Chronic Obstructive	EFOID:0000341	chronic obstructive pulmonary disease	Chronic obstructive airway disease	NA	Research Support, N.I.H., Extramural	Research Support, Non-U.S. Gov't	C
4	89875909	rs1964516	C	T	rs1964516	22080838	2.00E-09	NA	1.37	[1.23-1.52]	3,499 European ancestry cases; 1,922 European ancestry controls	European(5421)	ALL(5421)	EUR(5421)	ALL(5421)	Chronic obstructive pulmonary disease	HPOID:0006510	Chronic obstructive pulmonary disease	DOID:3083	chronic obstructive pulmonary disease	D029424	Pulmonary Disease, Chronic Obstructive	EFOID:0000341	chronic obstructive pulmonary disease	Chronic obstructive airway disease	NA	Research Support, N.I.H., Extramural	Research Support, U.S. Gov't, P.H.S.	Meta-Analysis
4	89883979	rs7671167	C	T	rs7671167	20173748	1.00E-11	NA	1.32	[1.19-1.47]	2,940 white cases; 1,380 white controls	NOPOP(4320)	ALL(4320)	NOPOP(4320)	ALL(4320)	Chronic obstructive pulmonary disease	HPOID:0006510	Chronic obstructive pulmonary disease	DOID:3083	chronic obstructive pulmonary disease	D029424	Pulmonary Disease, Chronic Obstructive	EFOID:0000341	chronic obstructive pulmonary disease	Chronic obstructive airway disease	NA	Research Support, N.I.H., Extramural	Research Support, Non-U.S. Gov't	Research Support, U.S. Gov't, Non-P.H.S.
4	89883979	rs7671167	C	T	rs7671167	21921092	8.22E-08	Chronic obstructive pulmonary disease (COPD)	NA	NA	58 Costa Rica descent cases; 57 Costa Rica descent controls	Costa Rica(115)	ALL(115)	HIS(115)	ALL(115)	chronic obstructive pulmonary disease	HPOID:0006510	Chronic obstructive pulmonary disease	DOID:3083	chronic obstructive pulmonary disease	D029424	Pulmonary Disease, Chronic Obstructive	EFOID:0000341	chronic obstructive pulmonary disease	Chronic obstructive airway disease	NA	Research Support, N.I.H., Extramural	Research Support, Non-U.S. Gov't	T
4	89886297	rs1903003	C	T	rs1903003	20173748	7.74E-08	NA	NA	NA	2,940 white cases; 1,380 white controls	NOPOP(4320)	ALL(4320)	NOPOP(4320)	ALL(4320)	Chronic obstructive pulmonary disease	HPOID:0006510	Chronic obstructive pulmonary disease	DOID:3083	chronic obstructive pulmonary disease	D029424	Pulmonary Disease, Chronic Obstructive	EFOID:0000341	chronic obstructive pulmonary disease	Chronic obstructive airway disease	NA	Research Support, N.I.H., Extramural	Research Support, Non-U.S. Gov't	Research Support, U.S. Gov't, Non-P.H.S.
4	89886297	rs1903003	C	T	rs1903003	21921092	6.87E-08	Chronic obstructive pulmonary disease (COPD)	NA	NA	58 Costa Rica descent cases; 57 Costa Rica descent controls	Costa Rica(115)	ALL(115)	HIS(115)	ALL(115)	chronic obstructive pulmonary disease	HPOID:0006510	Chronic obstructive pulmonary disease	DOID:3083	chronic obstructive pulmonary disease	D029424	Pulmonary Disease, Chronic Obstructive	EFOID:0000341	chronic obstructive pulmonary disease	Chronic obstructive airway disease	NA	Research Support, N.I.H., Extramural	Research Support, Non-U.S. Gov't	T
4	107000462	rs11097912	C	T	rs11097912	22837378	6.00E-06	smokers	1.18	NA	up to 3,368 European ancestry cases; up to 29,507 European ancestry controls	European(32875)	ALL(32875)	EUR(32875)	ALL(32875)	Airflow obstruction	HPOID:0006536	Obstructive lung disease	DOID:3083	chronic obstructive pulmonary disease	D000402	Airway Obstruction	EFOID:0003892	pulmonary function measurement	Chronic obstructive airway disease	NA	Research Support, N.I.H., Extramural	Meta-Analysis	Research Support, Non-U.S. Gov't
4	108115222	rs10516541	G	A	rs10516541	17903307	4.00E-06	NA	NA	NA	Up to 1,222 individuals	NOPOP(1222)	ALL(1222)	NOPOP(1222)	ALL(1222)	Mean forced vital capacity from 2 exams	HPOID:0006510	Chronic obstructive pulmonary disease	DOID:3083	chronic obstructive pulmonary disease	D008176	Lung Volume Measurements	NA	NA	Chronic obstructive airway disease	NA	Research Support, N.I.H., Extramural	Research Support, Non-U.S. Gov't	G
4	109217929	rs13144621	T	C	rs13144621	22837378	1.00E-06	All	1.16	NA	up to 3,368 European ancestry cases; up to 29,507 European ancestry controls	European(32875)	ALL(32875)	EUR(32875)	ALL(32875)	Airflow obstruction	HPOID:0006536	Obstructive lung disease	DOID:3083	chronic obstructive pulmonary disease	D000402	Airway Obstruction	EFOID:0003892	pulmonary function measurement	Chronic obstructive airway disease	NA	Research Support, N.I.H., Extramural	Meta-Analysis	Research Support, Non-U.S. Gov't
4	122607178	rs55645543	T	C	rs55645543	21685187	5.00E-07	Age at smoking initiation	4.39	NA	3,441 European ancestry ever-smokers with COPD	European(3441)	ALL(3441)	EUR(3441)	ALL(3441)	Chronic obstructive pulmonary disease	HPOID:0006510	Chronic obstructive pulmonary disease	DOID:3083	chronic obstructive pulmonary disease	D029424	Pulmonary Disease, Chronic Obstructive	EFOID:0000341	chronic obstructive pulmonary disease	Chronic obstructive airway disease	rs55645543-T	Randomized Controlled Trial	Multicenter Study	Research Support, N.I.H., Extramural
4	125449253	rs312495	T	C	rs312495	19300482	7.60E-05	NA	NA	NA	823 cases; 810 controls	NOPOP(1633)	ALL(1633)	NOPOP(1633)	ALL(1633)	Chronic obstructive pulmonary disease	HPOID:0006510	Chronic obstructive pulmonary disease	DOID:3083	chronic obstructive pulmonary disease	D029424	Pulmonary Disease, Chronic Obstructive	EFOID:0000341	chronic obstructive pulmonary disease	Chronic obstructive airway disease	NA	Research Support, N.I.H., Extramural	Research Support, U.S. Gov't, P.H.S.	Research Support, Non-U.S. Gov't
4	129890790	rs7655841	T	C	rs7655841	24621683	7.00E-07	(AA)	NA	NA	5,812 European ancestry cases; 3,955 European ancestry controls; 821 African American cases; 1,749 African American controls	African American(2570)	European(9767)	ALL(12337)	AFR(2570)	EUR(9767)	ALL(12337)	Chronic obstructive pulmonary disease (moderate to severe)	HPOID:0006510	Chronic obstructive pulmonary disease	DOID:3083	chronic obstructive pulmonary disease	NA	NA	NA	NA	Chronic obstructive airway disease	NA	Research Support, N.I.H., Extramural
4	136037410	rs4330400	A	G	rs4330400	22986903	0.0000073	NA	NA	NA	4,048 European ancestry cases	European(4048)	ALL(4048)	EUR(4048)	ALL(4048)	Chronic obstructive pulmonary disease (moderate to severe)	HPOID:0006510	Chronic obstructive pulmonary disease	DOID:3083	chronic obstructive pulmonary disease	NA	NA	NA	NA	Chronic obstructive airway disease	NA	Multicenter Study	Research Support, N.I.H., Extramural	Research Support, Non-U.S. Gov't
4	142005573	rs10007052	C	A	rs10007052	23144326	1.00E-07	TNFA	NA	NA	Up to 1,951 European ancestry smokers	European(1951)	ALL(1951)	EUR(1951)	ALL(1951)	Chronic obstructive pulmonary disease-related biomarkers	HPOID:0006510	Chronic obstructive pulmonary disease	DOID:3083	chronic obstructive pulmonary disease	D029424	Pulmonary Disease, Chronic Obstructive	EFOID:0005080	surfactant protein D measurement	Chronic obstructive airway disease	rs10007052-A	Clinical Trial	Research Support, N.I.H., Extramural	Research Support, Non-U.S. Gov't
4	145480780	rs1828591	A	G	rs1828591	19300482	1.00E-07	NA	1.38	[1.17-1.63]	823 cases; 810 controls	NOPOP(1633)	ALL(1633)	NOPOP(1633)	ALL(1633)	Chronic obstructive pulmonary disease	HPOID:0006510	Chronic obstructive pulmonary disease	DOID:3083	chronic obstructive pulmonary disease	D029424	Pulmonary Disease, Chronic Obstructive	EFOID:0000341	chronic obstructive pulmonary disease	Chronic obstructive airway disease	NA	Research Support, N.I.H., Extramural	Research Support, U.S. Gov't, P.H.S.	Research Support, Non-U.S. Gov't
4	145480780	rs1828591	A	G	rs1828591	20173748	1.18E-07	NA	NA	NA	2,940 white cases; 1,380 white controls	NOPOP(4320)	ALL(4320)	NOPOP(4320)	ALL(4320)	Chronic obstructive pulmonary disease	HPOID:0006510	Chronic obstructive pulmonary disease	DOID:3083	chronic obstructive pulmonary disease	D029424	Pulmonary Disease, Chronic Obstructive	EFOID:0000341	chronic obstructive pulmonary disease	Chronic obstructive airway disease	NA	Research Support, N.I.H., Extramural	Research Support, Non-U.S. Gov't	Research Support, U.S. Gov't, Non-P.H.S.
4	145486389	rs13118928	A	G	rs13118928	20173748	5.00E-07	NA	1.25	[1.14-1.37]	2,940 white cases; 1,380 white controls	NOPOP(4320)	ALL(4320)	NOPOP(4320)	ALL(4320)	Chronic obstructive pulmonary disease	HPOID:0006510	Chronic obstructive pulmonary disease	DOID:3083	chronic obstructive pulmonary disease	D029424	Pulmonary Disease, Chronic Obstructive	EFOID:0000341	chronic obstructive pulmonary disease	Chronic obstructive airway disease	NA	Research Support, N.I.H., Extramural	Research Support, Non-U.S. Gov't	Research Support, U.S. Gov't, Non-P.H.S.
4	145506456	rs13141641	T	C	rs13141641	22080838	3.00E-07	NA	1.32	[1.14-1.54]	3,499 European ancestry cases; 1,922 European ancestry controls	European(5421)	ALL(5421)	EUR(5421)	ALL(5421)	Chronic obstructive pulmonary disease	HPOID:0006510	Chronic obstructive pulmonary disease	DOID:3083	chronic obstructive pulmonary disease	D029424	Pulmonary Disease, Chronic Obstructive	EFOID:0000341	chronic obstructive pulmonary disease	Chronic obstructive airway disease	NA	Research Support, N.I.H., Extramural	Research Support, U.S. Gov't, P.H.S.	Meta-Analysis
4	145506456	rs13141641	T	C	rs13141641	24621683	2.00E-12	NA	1.27	[1.19-1.36]	5,812 European ancestry cases; 3,955 European ancestry controls; 821 African American cases; 1,749 African American controls	African American(2570)	European(9767)	ALL(12337)	AFR(2570)	EUR(9767)	ALL(12337)	Chronic obstructive pulmonary disease (moderate to severe)	HPOID:0006510	Chronic obstructive pulmonary disease	DOID:3083	chronic obstructive pulmonary disease	NA	NA	NA	NA	Chronic obstructive airway disease	rs13141641-T	Research Support, N.I.H., Extramural
4	145506456	rs13141641	T	C	rs13141641	24621683	4.00E-15	NA	1.39	[1.28-1.51]	3,145 European ancestry cases; 3,955 European ancestry controls; 352 African American cases; 1,749 African American controls	African American(2101)	European(7100)	ALL(9201)	AFR(2101)	EUR(7100)	ALL(9201)	Chronic obstructive pulmonary disease (severe)	HPOID:0006510	Chronic obstructive pulmonary disease	DOID:3083	chronic obstructive pulmonary disease	NA	NA	NA	NA	Chronic obstructive airway disease	rs13141641-T	Research Support, N.I.H., Extramural
4	145506558	rs6852830	C	A	rs6852830	19300482	6.66E-05	NA	NA	NA	823 cases; 810 controls	NOPOP(1633)	ALL(1633)	NOPOP(1633)	ALL(1633)	Chronic obstructive pulmonary disease	HPOID:0006510	Chronic obstructive pulmonary disease	DOID:3083	chronic obstructive pulmonary disease	D029424	Pulmonary Disease, Chronic Obstructive	EFOID:0000341	chronic obstructive pulmonary disease	Chronic obstructive airway disease	NA	Research Support, N.I.H., Extramural	Research Support, U.S. Gov't, P.H.S.	Research Support, Non-U.S. Gov't
4	145511194	rs1996020	A	C	rs1996020	19300482	4.86E-05	NA	NA	NA	823 cases; 810 controls	NOPOP(1633)	ALL(1633)	NOPOP(1633)	ALL(1633)	Chronic obstructive pulmonary disease	HPOID:0006510	Chronic obstructive pulmonary disease	DOID:3083	chronic obstructive pulmonary disease	D029424	Pulmonary Disease, Chronic Obstructive	EFOID:0000341	chronic obstructive pulmonary disease	Chronic obstructive airway disease	NA	Research Support, N.I.H., Extramural	Research Support, U.S. Gov't, P.H.S.	Research Support, Non-U.S. Gov't
4	154850835	rs11099924	A	G	rs11099924	23990791	3.50E-05	imputed, conditional on PI S and Z alleles in GWAS stage only	0.03	NA	1,392 European ancestry individuals	European(1392)	ALL(1392)	EUR(1392)	ALL(1392)	Serum alpha1-antitrypsin levels	HPOID:0006510	Chronic obstructive pulmonary disease	DOID:3083	chronic obstructive pulmonary disease	NA	NA	NA	NA	Chronic obstructive airway disease	NA	Research Support, N.I.H., Extramural	Research Support, Non-U.S. Gov't	Research Support, U.S. Gov't, Non-P.H.S.
4	154854591	rs4411966	A	G	rs4411966	23990791	3.90E-05	imputed, conditional on PI S and Z alleles in GWAS stage only	0.03	NA	1,392 European ancestry individuals	European(1392)	ALL(1392)	EUR(1392)	ALL(1392)	Serum alpha1-antitrypsin levels	HPOID:0006510	Chronic obstructive pulmonary disease	DOID:3083	chronic obstructive pulmonary disease	NA	NA	NA	NA	Chronic obstructive airway disease	NA	Research Support, N.I.H., Extramural	Research Support, Non-U.S. Gov't	Research Support, U.S. Gov't, Non-P.H.S.
4	154854674	rs4622983	G	A	rs4622983	23990791	4.71E-05	imputed, conditional on PI S and Z alleles in GWAS stage only	0.03	NA	1,392 European ancestry individuals	European(1392)	ALL(1392)	EUR(1392)	ALL(1392)	Serum alpha1-antitrypsin levels	HPOID:0006510	Chronic obstructive pulmonary disease	DOID:3083	chronic obstructive pulmonary disease	NA	NA	NA	NA	Chronic obstructive airway disease	NA	Research Support, N.I.H., Extramural	Research Support, Non-U.S. Gov't	Research Support, U.S. Gov't, Non-P.H.S.
4	155481289	rs4508864	C	T	rs4508864	23144326	6.00E-06	FG	NA	NA	Up to 1,951 European ancestry smokers	European(1951)	ALL(1951)	EUR(1951)	ALL(1951)	Chronic obstructive pulmonary disease-related biomarkers	HPOID:0006510	Chronic obstructive pulmonary disease	DOID:3083	chronic obstructive pulmonary disease	D029424	Pulmonary Disease, Chronic Obstructive	EFOID:0005080	surfactant protein D measurement	Chronic obstructive airway disease	rs4508864-T	Clinical Trial	Research Support, N.I.H., Extramural	Research Support, Non-U.S. Gov't
5	15014182	rs7341022	G	A	rs7341022	19300482	9.97E-08	NA	NA	NA	823 cases; 810 controls	NOPOP(1633)	ALL(1633)	NOPOP(1633)	ALL(1633)	Chronic obstructive pulmonary disease	HPOID:0006510	Chronic obstructive pulmonary disease	DOID:3083	chronic obstructive pulmonary disease	D029424	Pulmonary Disease, Chronic Obstructive	EFOID:0000341	chronic obstructive pulmonary disease	Chronic obstructive airway disease	NA	Research Support, N.I.H., Extramural	Research Support, U.S. Gov't, P.H.S.	Research Support, Non-U.S. Gov't
5	15018537	rs9686327	G	A	rs9686327	19300482	9.84E-08	NA	NA	NA	823 cases; 810 controls	NOPOP(1633)	ALL(1633)	NOPOP(1633)	ALL(1633)	Chronic obstructive pulmonary disease	HPOID:0006510	Chronic obstructive pulmonary disease	DOID:3083	chronic obstructive pulmonary disease	D029424	Pulmonary Disease, Chronic Obstructive	EFOID:0000341	chronic obstructive pulmonary disease	Chronic obstructive airway disease	NA	Research Support, N.I.H., Extramural	Research Support, U.S. Gov't, P.H.S.	Research Support, Non-U.S. Gov't
5	15022112	rs7727670	G	T	rs7727670	19300482	8.38E-08	NA	NA	NA	823 cases; 810 controls	NOPOP(1633)	ALL(1633)	NOPOP(1633)	ALL(1633)	Chronic obstructive pulmonary disease	HPOID:0006510	Chronic obstructive pulmonary disease	DOID:3083	chronic obstructive pulmonary disease	D029424	Pulmonary Disease, Chronic Obstructive	EFOID:0000341	chronic obstructive pulmonary disease	Chronic obstructive airway disease	NA	Research Support, N.I.H., Extramural	Research Support, U.S. Gov't, P.H.S.	Research Support, Non-U.S. Gov't
5	15039327	rs735243	G	A	rs735243	19300482	2.02E-07	NA	NA	NA	823 cases; 810 controls	NOPOP(1633)	ALL(1633)	NOPOP(1633)	ALL(1633)	Chronic obstructive pulmonary disease	HPOID:0006510	Chronic obstructive pulmonary disease	DOID:3083	chronic obstructive pulmonary disease	D029424	Pulmonary Disease, Chronic Obstructive	EFOID:0000341	chronic obstructive pulmonary disease	Chronic obstructive airway disease	NA	Research Support, N.I.H., Extramural	Research Support, U.S. Gov't, P.H.S.	Research Support, Non-U.S. Gov't
5	15044842	rs30539	G	A	rs30539	19300482	3.38E-06	NA	NA	NA	823 cases; 810 controls	NOPOP(1633)	ALL(1633)	NOPOP(1633)	ALL(1633)	Chronic obstructive pulmonary disease	HPOID:0006510	Chronic obstructive pulmonary disease	DOID:3083	chronic obstructive pulmonary disease	D029424	Pulmonary Disease, Chronic Obstructive	EFOID:0000341	chronic obstructive pulmonary disease	Chronic obstructive airway disease	NA	Research Support, N.I.H., Extramural	Research Support, U.S. Gov't, P.H.S.	Research Support, Non-U.S. Gov't
5	15054802	rs1080879	T	C	rs1080879	19300482	7.69E-07	NA	NA	NA	823 cases; 810 controls	NOPOP(1633)	ALL(1633)	NOPOP(1633)	ALL(1633)	Chronic obstructive pulmonary disease	HPOID:0006510	Chronic obstructive pulmonary disease	DOID:3083	chronic obstructive pulmonary disease	D029424	Pulmonary Disease, Chronic Obstructive	EFOID:0000341	chronic obstructive pulmonary disease	Chronic obstructive airway disease	NA	Research Support, N.I.H., Extramural	Research Support, U.S. Gov't, P.H.S.	Research Support, Non-U.S. Gov't
5	15087791	rs32466	C	T	rs32466	19300482	8.31E-07	NA	NA	NA	823 cases; 810 controls	NOPOP(1633)	ALL(1633)	NOPOP(1633)	ALL(1633)	Chronic obstructive pulmonary disease	HPOID:0006510	Chronic obstructive pulmonary disease	DOID:3083	chronic obstructive pulmonary disease	D029424	Pulmonary Disease, Chronic Obstructive	EFOID:0000341	chronic obstructive pulmonary disease	Chronic obstructive airway disease	NA	Research Support, N.I.H., Extramural	Research Support, U.S. Gov't, P.H.S.	Research Support, Non-U.S. Gov't
5	15114063	rs16903825	T	C	rs16903825	19300482	2.35E-05	NA	NA	NA	823 cases; 810 controls	NOPOP(1633)	ALL(1633)	NOPOP(1633)	ALL(1633)	Chronic obstructive pulmonary disease	HPOID:0006510	Chronic obstructive pulmonary disease	DOID:3083	chronic obstructive pulmonary disease	D029424	Pulmonary Disease, Chronic Obstructive	EFOID:0000341	chronic obstructive pulmonary disease	Chronic obstructive airway disease	NA	Research Support, N.I.H., Extramural	Research Support, U.S. Gov't, P.H.S.	Research Support, Non-U.S. Gov't
5	15117438	rs32447	G	A	rs32447	19300482	6.46E-05	NA	NA	NA	823 cases; 810 controls	NOPOP(1633)	ALL(1633)	NOPOP(1633)	ALL(1633)	Chronic obstructive pulmonary disease	HPOID:0006510	Chronic obstructive pulmonary disease	DOID:3083	chronic obstructive pulmonary disease	D029424	Pulmonary Disease, Chronic Obstructive	EFOID:0000341	chronic obstructive pulmonary disease	Chronic obstructive airway disease	NA	Research Support, N.I.H., Extramural	Research Support, U.S. Gov't, P.H.S.	Research Support, Non-U.S. Gov't
5	52977472	rs4147743	T	A	rs4147743	22837378	9.99E-10	NA	NA	NA	up to 3,368 European ancestry cases; up to 29,507 European ancestry controls	European(32875)	ALL(32875)	EUR(32875)	ALL(32875)	Airflow obstruction	HPOID:0006536	Obstructive lung disease	DOID:3083	chronic obstructive pulmonary disease	D000402	Airway Obstruction	EFOID:0003892	pulmonary function measurement	Chronic obstructive airway disease	NA	Research Support, N.I.H., Extramural	Meta-Analysis	Research Support, Non-U.S. Gov't
5	57972853	rs158990	A	G	rs158990	19300482	5.04E-05	NA	NA	NA	823 cases; 810 controls	NOPOP(1633)	ALL(1633)	NOPOP(1633)	ALL(1633)	Chronic obstructive pulmonary disease	HPOID:0006510	Chronic obstructive pulmonary disease	DOID:3083	chronic obstructive pulmonary disease	D029424	Pulmonary Disease, Chronic Obstructive	EFOID:0000341	chronic obstructive pulmonary disease	Chronic obstructive airway disease	NA	Research Support, N.I.H., Extramural	Research Support, U.S. Gov't, P.H.S.	Research Support, Non-U.S. Gov't
5	79412328	rs4703798	T	C	rs4703798	23990791	7.50E-06	imputed, conditional on PI S and Z alleles in GWAS stage only	0.03	NA	1,392 European ancestry individuals	European(1392)	ALL(1392)	EUR(1392)	ALL(1392)	Serum alpha1-antitrypsin levels	HPOID:0006510	Chronic obstructive pulmonary disease	DOID:3083	chronic obstructive pulmonary disease	NA	NA	NA	NA	Chronic obstructive airway disease	NA	Research Support, N.I.H., Extramural	Research Support, Non-U.S. Gov't	Research Support, U.S. Gov't, Non-P.H.S.
5	111443754	rs26566	T	C	rs26566	19300482	7.81E-05	NA	NA	NA	823 cases; 810 controls	NOPOP(1633)	ALL(1633)	NOPOP(1633)	ALL(1633)	Chronic obstructive pulmonary disease	HPOID:0006510	Chronic obstructive pulmonary disease	DOID:3083	chronic obstructive pulmonary disease	D029424	Pulmonary Disease, Chronic Obstructive	EFOID:0000341	chronic obstructive pulmonary disease	Chronic obstructive airway disease	NA	Research Support, N.I.H., Extramural	Research Support, U.S. Gov't, P.H.S.	Research Support, Non-U.S. Gov't
5	111444522	rs25796	T	C	rs25796	19300482	6.43E-05	NA	NA	NA	823 cases; 810 controls	NOPOP(1633)	ALL(1633)	NOPOP(1633)	ALL(1633)	Chronic obstructive pulmonary disease	HPOID:0006510	Chronic obstructive pulmonary disease	DOID:3083	chronic obstructive pulmonary disease	D029424	Pulmonary Disease, Chronic Obstructive	EFOID:0000341	chronic obstructive pulmonary disease	Chronic obstructive airway disease	NA	Research Support, N.I.H., Extramural	Research Support, U.S. Gov't, P.H.S.	Research Support, Non-U.S. Gov't
5	129721857	rs4835994	T	C	rs4835994	23990791	3.38E-05	imputed, conditional on PI S and Z alleles in GWAS stage only	0.04	NA	1,392 European ancestry individuals	European(1392)	ALL(1392)	EUR(1392)	ALL(1392)	Serum alpha1-antitrypsin levels	HPOID:0006510	Chronic obstructive pulmonary disease	DOID:3083	chronic obstructive pulmonary disease	NA	NA	NA	NA	Chronic obstructive airway disease	NA	Research Support, N.I.H., Extramural	Research Support, Non-U.S. Gov't	Research Support, U.S. Gov't, Non-P.H.S.
5	129797899	rs6893779	A	C	rs6893779	23990791	4.63E-05	imputed, conditional on PI S and Z alleles in GWAS stage only	0.03	NA	1,392 European ancestry individuals	European(1392)	ALL(1392)	EUR(1392)	ALL(1392)	Serum alpha1-antitrypsin levels	HPOID:0006510	Chronic obstructive pulmonary disease	DOID:3083	chronic obstructive pulmonary disease	NA	NA	NA	NA	Chronic obstructive airway disease	NA	Research Support, N.I.H., Extramural	Research Support, Non-U.S. Gov't	Research Support, U.S. Gov't, Non-P.H.S.
5	138850905	rs13181561	G	A	rs13181561	23144326	6.00E-06	FG	NA	NA	Up to 1,951 European ancestry smokers	European(1951)	ALL(1951)	EUR(1951)	ALL(1951)	Chronic obstructive pulmonary disease-related biomarkers	HPOID:0006510	Chronic obstructive pulmonary disease	DOID:3083	chronic obstructive pulmonary disease	D029424	Pulmonary Disease, Chronic Obstructive	EFOID:0005080	surfactant protein D measurement	Chronic obstructive airway disease	rs13181561-G	Clinical Trial	Research Support, N.I.H., Extramural	Research Support, Non-U.S. Gov't
5	147856333	rs7733088	G	A	rs7733088	22837378	4.00E-09	Smoker	1.23	NA	up to 3,368 European ancestry cases; up to 29,507 European ancestry controls	European(32875)	ALL(32875)	EUR(32875)	ALL(32875)	Airflow obstruction	HPOID:0006536	Obstructive lung disease	DOID:3083	chronic obstructive pulmonary disease	D000402	Airway Obstruction	EFOID:0003892	pulmonary function measurement	Chronic obstructive airway disease	NA	Research Support, N.I.H., Extramural	Meta-Analysis	Research Support, Non-U.S. Gov't
5	148834935	rs729319	C	A	rs729319	19300482	3.36E-05	NA	NA	NA	823 cases; 810 controls	NOPOP(1633)	ALL(1633)	NOPOP(1633)	ALL(1633)	Chronic obstructive pulmonary disease	HPOID:0006510	Chronic obstructive pulmonary disease	DOID:3083	chronic obstructive pulmonary disease	D029424	Pulmonary Disease, Chronic Obstructive	EFOID:0000341	chronic obstructive pulmonary disease	Chronic obstructive airway disease	NA	Research Support, N.I.H., Extramural	Research Support, U.S. Gov't, P.H.S.	Research Support, Non-U.S. Gov't
5	161702316	rs2963162	G	T	rs2963162	19300482	1.54E-05	NA	NA	NA	823 cases; 810 controls	NOPOP(1633)	ALL(1633)	NOPOP(1633)	ALL(1633)	Chronic obstructive pulmonary disease	HPOID:0006510	Chronic obstructive pulmonary disease	DOID:3083	chronic obstructive pulmonary disease	D029424	Pulmonary Disease, Chronic Obstructive	EFOID:0000341	chronic obstructive pulmonary disease	Chronic obstructive airway disease	NA	Research Support, N.I.H., Extramural	Research Support, U.S. Gov't, P.H.S.	Research Support, Non-U.S. Gov't
6	4874759	rs73717741	C	G	rs73717741	21685187	3.00E-07	Age at smoking initiation	11.9	NA	3,441 European ancestry ever-smokers with COPD	European(3441)	ALL(3441)	EUR(3441)	ALL(3441)	Chronic obstructive pulmonary disease	HPOID:0006510	Chronic obstructive pulmonary disease	DOID:3083	chronic obstructive pulmonary disease	D029424	Pulmonary Disease, Chronic Obstructive	EFOID:0000341	chronic obstructive pulmonary disease	Chronic obstructive airway disease	rs73717741-G	Randomized Controlled Trial	Multicenter Study	Research Support, N.I.H., Extramural
6	9788659	rs12662524	A	G	rs12662524	19300482	8.11E-05	NA	NA	NA	823 cases; 810 controls	NOPOP(1633)	ALL(1633)	NOPOP(1633)	ALL(1633)	Chronic obstructive pulmonary disease	HPOID:0006510	Chronic obstructive pulmonary disease	DOID:3083	chronic obstructive pulmonary disease	D029424	Pulmonary Disease, Chronic Obstructive	EFOID:0000341	chronic obstructive pulmonary disease	Chronic obstructive airway disease	NA	Research Support, N.I.H., Extramural	Research Support, U.S. Gov't, P.H.S.	Research Support, Non-U.S. Gov't
6	20920123	rs4712564	A	G	rs4712564	19300482	8.79E-05	NA	NA	NA	823 cases; 810 controls	NOPOP(1633)	ALL(1633)	NOPOP(1633)	ALL(1633)	Chronic obstructive pulmonary disease	HPOID:0006510	Chronic obstructive pulmonary disease	DOID:3083	chronic obstructive pulmonary disease	D029424	Pulmonary Disease, Chronic Obstructive	EFOID:0000341	chronic obstructive pulmonary disease	Chronic obstructive airway disease	NA	Research Support, N.I.H., Extramural	Research Support, U.S. Gov't, P.H.S.	Research Support, Non-U.S. Gov't
6	20940761	rs9350301	T	G	rs9350301	19300482	8.93E-05	NA	NA	NA	823 cases; 810 controls	NOPOP(1633)	ALL(1633)	NOPOP(1633)	ALL(1633)	Chronic obstructive pulmonary disease	HPOID:0006510	Chronic obstructive pulmonary disease	DOID:3083	chronic obstructive pulmonary disease	D029424	Pulmonary Disease, Chronic Obstructive	EFOID:0000341	chronic obstructive pulmonary disease	Chronic obstructive airway disease	NA	Research Support, N.I.H., Extramural	Research Support, U.S. Gov't, P.H.S.	Research Support, Non-U.S. Gov't
6	20955332	rs7775523	T	C	rs7775523	19300482	5.12E-05	NA	NA	NA	823 cases; 810 controls	NOPOP(1633)	ALL(1633)	NOPOP(1633)	ALL(1633)	Chronic obstructive pulmonary disease	HPOID:0006510	Chronic obstructive pulmonary disease	DOID:3083	chronic obstructive pulmonary disease	D029424	Pulmonary Disease, Chronic Obstructive	EFOID:0000341	chronic obstructive pulmonary disease	Chronic obstructive airway disease	NA	Research Support, N.I.H., Extramural	Research Support, U.S. Gov't, P.H.S.	Research Support, Non-U.S. Gov't
6	24306387	rs16889038	T	G	rs16889038	22837378	8.00E-07	FEV1 65%	1.39	NA	up to 3,368 European ancestry cases; up to 29,507 European ancestry controls	European(32875)	ALL(32875)	EUR(32875)	ALL(32875)	Airflow obstruction	HPOID:0006536	Obstructive lung disease	DOID:3083	chronic obstructive pulmonary disease	D000402	Airway Obstruction	EFOID:0003892	pulmonary function measurement	Chronic obstructive airway disease	NA	Research Support, N.I.H., Extramural	Meta-Analysis	Research Support, Non-U.S. Gov't
6	31097301	rs3130559	C	T	rs3130559	23144326	8.00E-09	SP-D	NA	NA	Up to 1,951 European ancestry smokers	European(1951)	ALL(1951)	EUR(1951)	ALL(1951)	Chronic obstructive pulmonary disease-related biomarkers	HPOID:0006510	Chronic obstructive pulmonary disease	DOID:3083	chronic obstructive pulmonary disease	D029424	Pulmonary Disease, Chronic Obstructive	EFOID:0005080	surfactant protein D measurement	Chronic obstructive airway disease	rs3130559-T	Clinical Trial	Research Support, N.I.H., Extramural	Research Support, Non-U.S. Gov't
6	31107187	rs1265093	G	A	rs1265093	23144326	6.00E-09	SP-D	NA	NA	Up to 1,951 European ancestry smokers	European(1951)	ALL(1951)	EUR(1951)	ALL(1951)	Chronic obstructive pulmonary disease-related biomarkers	HPOID:0006510	Chronic obstructive pulmonary disease	DOID:3083	chronic obstructive pulmonary disease	D029424	Pulmonary Disease, Chronic Obstructive	EFOID:0005080	surfactant protein D measurement	Chronic obstructive airway disease	rs1265093-A	Clinical Trial	Research Support, N.I.H., Extramural	Research Support, Non-U.S. Gov't
6	31240431	rs2074488	G	T	rs2074488	23144326	2.00E-10	SP-D	NA	NA	Up to 1,951 European ancestry smokers	European(1951)	ALL(1951)	EUR(1951)	ALL(1951)	Chronic obstructive pulmonary disease-related biomarkers	HPOID:0006510	Chronic obstructive pulmonary disease	DOID:3083	chronic obstructive pulmonary disease	D029424	Pulmonary Disease, Chronic Obstructive	EFOID:0005080	surfactant protein D measurement	Chronic obstructive airway disease	rs2074488-T	Clinical Trial	Research Support, N.I.H., Extramural	Research Support, Non-U.S. Gov't
6	31346822	rs9266629	T	C	rs9266629	23144326	4.00E-10	SP-D	NA	NA	Up to 1,951 European ancestry smokers	European(1951)	ALL(1951)	EUR(1951)	ALL(1951)	Chronic obstructive pulmonary disease-related biomarkers	HPOID:0006510	Chronic obstructive pulmonary disease	DOID:3083	chronic obstructive pulmonary disease	D029424	Pulmonary Disease, Chronic Obstructive	EFOID:0005080	surfactant protein D measurement	Chronic obstructive airway disease	rs9266629-C	Clinical Trial	Research Support, N.I.H., Extramural	Research Support, Non-U.S. Gov't
6	32124424	rs10947233	G	T	rs10947233	24383474	3.20E-08	NA	0.15	[0.097-0.20] unit decrease	2,587 European ancestry individuals; 2,510 African American individuals; 2,113 Hispanic individuals; 704 Chinese ancestry individuals	Chinese(704)	African American(2510)	European(2587)	Hispanic(2113)	ALL(7914)	ASN(704)	HIS(2113)	AFR(2510)	EUR(2587)	ALL(7914)	Pulmonary emphysema	HPOID:0006510	Chronic obstructive pulmonary disease	DOID:9675	pulmonary emphysema	NA	NA	NA
6	33465482	rs9394152	C	T	rs9394152	21685187	7.00E-08	Age at smoking initiation	22.22	NA	3,441 European ancestry ever-smokers with COPD	European(3441)	ALL(3441)	EUR(3441)	ALL(3441)	Chronic obstructive pulmonary disease	HPOID:0006510	Chronic obstructive pulmonary disease	DOID:3083	chronic obstructive pulmonary disease	D029424	Pulmonary Disease, Chronic Obstructive	EFOID:0000341	chronic obstructive pulmonary disease	Chronic obstructive airway disease	rs9394152-C	Randomized Controlled Trial	Multicenter Study	Research Support, N.I.H., Extramural
6	33478496	rs9296092	A	G	rs9296092	21685187	6.00E-07	Age at smoking initiation	NA	NA	3,441 European ancestry ever-smokers with COPD	European(3441)	ALL(3441)	EUR(3441)	ALL(3441)	Chronic obstructive pulmonary disease	HPOID:0006510	Chronic obstructive pulmonary disease	DOID:3083	chronic obstructive pulmonary disease	D029424	Pulmonary Disease, Chronic Obstructive	EFOID:0000341	chronic obstructive pulmonary disease	Chronic obstructive airway disease	NA	Randomized Controlled Trial	Multicenter Study	Research Support, N.I.H., Extramural
6	72300534	rs12193019	T	C	rs12193019	19300482	2.27E-05	NA	NA	NA	823 cases; 810 controls	NOPOP(1633)	ALL(1633)	NOPOP(1633)	ALL(1633)	Chronic obstructive pulmonary disease	HPOID:0006510	Chronic obstructive pulmonary disease	DOID:3083	chronic obstructive pulmonary disease	D029424	Pulmonary Disease, Chronic Obstructive	EFOID:0000341	chronic obstructive pulmonary disease	Chronic obstructive airway disease	NA	Research Support, N.I.H., Extramural	Research Support, U.S. Gov't, P.H.S.	Research Support, Non-U.S. Gov't
6	72337017	rs10942957	C	T	rs10942957	19300482	3.15E-05	NA	NA	NA	823 cases; 810 controls	NOPOP(1633)	ALL(1633)	NOPOP(1633)	ALL(1633)	Chronic obstructive pulmonary disease	HPOID:0006510	Chronic obstructive pulmonary disease	DOID:3083	chronic obstructive pulmonary disease	D029424	Pulmonary Disease, Chronic Obstructive	EFOID:0000341	chronic obstructive pulmonary disease	Chronic obstructive airway disease	NA	Research Support, N.I.H., Extramural	Research Support, U.S. Gov't, P.H.S.	Research Support, Non-U.S. Gov't
6	72346472	rs1575208	C	T	rs1575208	19300482	1.46E-05	NA	NA	NA	823 cases; 810 controls	NOPOP(1633)	ALL(1633)	NOPOP(1633)	ALL(1633)	Chronic obstructive pulmonary disease	HPOID:0006510	Chronic obstructive pulmonary disease	DOID:3083	chronic obstructive pulmonary disease	D029424	Pulmonary Disease, Chronic Obstructive	EFOID:0000341	chronic obstructive pulmonary disease	Chronic obstructive airway disease	NA	Research Support, N.I.H., Extramural	Research Support, U.S. Gov't, P.H.S.	Research Support, Non-U.S. Gov't
6	73376868	rs12194741	T	C	rs12194741	22986903	0.0000018	NA	NA	NA	4,048 European ancestry cases	European(4048)	ALL(4048)	EUR(4048)	ALL(4048)	Chronic obstructive pulmonary disease (moderate to severe)	HPOID:0006510	Chronic obstructive pulmonary disease	DOID:3083	chronic obstructive pulmonary disease	NA	NA	NA	NA	Chronic obstructive airway disease	NA	Multicenter Study	Research Support, N.I.H., Extramural	Research Support, Non-U.S. Gov't
6	93713805	rs652520	T	C	rs652520	23144326	2.00E-06	CRP	NA	NA	Up to 1,951 European ancestry smokers	European(1951)	ALL(1951)	EUR(1951)	ALL(1951)	Chronic obstructive pulmonary disease-related biomarkers	HPOID:0006510	Chronic obstructive pulmonary disease	DOID:3083	chronic obstructive pulmonary disease	D029424	Pulmonary Disease, Chronic Obstructive	EFOID:0005080	surfactant protein D measurement	Chronic obstructive airway disease	rs652520-C	Clinical Trial	Research Support, N.I.H., Extramural	Research Support, Non-U.S. Gov't
6	127900557	rs9482826	A	G	rs9482826	19300482	5.44E-05	NA	NA	NA	823 cases; 810 controls	NOPOP(1633)	ALL(1633)	NOPOP(1633)	ALL(1633)	Chronic obstructive pulmonary disease	HPOID:0006510	Chronic obstructive pulmonary disease	DOID:3083	chronic obstructive pulmonary disease	D029424	Pulmonary Disease, Chronic Obstructive	EFOID:0000341	chronic obstructive pulmonary disease	Chronic obstructive airway disease	NA	Research Support, N.I.H., Extramural	Research Support, U.S. Gov't, P.H.S.	Research Support, Non-U.S. Gov't
6	142753338	rs1329705	G	A	rs1329705	22837378	3.00E-06	FEV1 65%	1.27	NA	up to 3,368 European ancestry cases; up to 29,507 European ancestry controls	European(32875)	ALL(32875)	EUR(32875)	ALL(32875)	Airflow obstruction	HPOID:0006536	Obstructive lung disease	DOID:3083	chronic obstructive pulmonary disease	D000402	Airway Obstruction	EFOID:0003892	pulmonary function measurement	Chronic obstructive airway disease	NA	Research Support, N.I.H., Extramural	Meta-Analysis	Research Support, Non-U.S. Gov't
6	144344172	rs9484838	T	C	rs9484838	23990791	3.34E-05	imputed, conditional on PI S and Z alleles in GWAS stage only	0.04	NA	1,392 European ancestry individuals	European(1392)	ALL(1392)	EUR(1392)	ALL(1392)	Serum alpha1-antitrypsin levels	HPOID:0006510	Chronic obstructive pulmonary disease	DOID:3083	chronic obstructive pulmonary disease	NA	NA	NA	NA	Chronic obstructive airway disease	NA	Research Support, N.I.H., Extramural	Research Support, Non-U.S. Gov't	Research Support, U.S. Gov't, Non-P.H.S.
6	149322058	rs9390650	C	T	rs9390650	23990791	2.78E-05	imputed, conditional on PI S and Z alleles in GWAS stage only	0.03	NA	1,392 European ancestry individuals	European(1392)	ALL(1392)	EUR(1392)	ALL(1392)	Serum alpha1-antitrypsin levels	HPOID:0006510	Chronic obstructive pulmonary disease	DOID:3083	chronic obstructive pulmonary disease	NA	NA	NA	NA	Chronic obstructive airway disease	NA	Research Support, N.I.H., Extramural	Research Support, Non-U.S. Gov't	Research Support, U.S. Gov't, Non-P.H.S.
6	149331339	rs7770997	A	G	rs7770997	23990791	3.16E-05	imputed, conditional on PI S and Z alleles in GWAS stage only	0.03	NA	1,392 European ancestry individuals	European(1392)	ALL(1392)	EUR(1392)	ALL(1392)	Serum alpha1-antitrypsin levels	HPOID:0006510	Chronic obstructive pulmonary disease	DOID:3083	chronic obstructive pulmonary disease	NA	NA	NA	NA	Chronic obstructive airway disease	NA	Research Support, N.I.H., Extramural	Research Support, Non-U.S. Gov't	Research Support, U.S. Gov't, Non-P.H.S.
6	149354801	rs6930963	C	G	rs6930963	23990791	4.55E-05	imputed, conditional on PI S and Z alleles in GWAS stage only	0.03	NA	1,392 European ancestry individuals	European(1392)	ALL(1392)	EUR(1392)	ALL(1392)	Serum alpha1-antitrypsin levels	HPOID:0006510	Chronic obstructive pulmonary disease	DOID:3083	chronic obstructive pulmonary disease	NA	NA	NA	NA	Chronic obstructive airway disease	NA	Research Support, N.I.H., Extramural	Research Support, Non-U.S. Gov't	Research Support, U.S. Gov't, Non-P.H.S.
7	28432476	rs7799265	C	G	rs7799265	22837378	2.00E-06	FEV1 65%	1.54	NA	up to 3,368 European ancestry cases; up to 29,507 European ancestry controls	European(32875)	ALL(32875)	EUR(32875)	ALL(32875)	Airflow obstruction	HPOID:0006536	Obstructive lung disease	DOID:3083	chronic obstructive pulmonary disease	D000402	Airway Obstruction	EFOID:0003892	pulmonary function measurement	Chronic obstructive airway disease	NA	Research Support, N.I.H., Extramural	Meta-Analysis	Research Support, Non-U.S. Gov't
7	36210485	rs6973373	G	A	rs6973373	19300482	3.32E-05	NA	NA	NA	823 cases; 810 controls	NOPOP(1633)	ALL(1633)	NOPOP(1633)	ALL(1633)	Chronic obstructive pulmonary disease	HPOID:0006510	Chronic obstructive pulmonary disease	DOID:3083	chronic obstructive pulmonary disease	D029424	Pulmonary Disease, Chronic Obstructive	EFOID:0000341	chronic obstructive pulmonary disease	Chronic obstructive airway disease	NA	Research Support, N.I.H., Extramural	Research Support, U.S. Gov't, P.H.S.	Research Support, Non-U.S. Gov't
7	67354119	rs12698626	C	T	rs12698626	23990791	4.20E-05	imputed, conditional on PI S and Z alleles in GWAS stage only	0.03	NA	1,392 European ancestry individuals	European(1392)	ALL(1392)	EUR(1392)	ALL(1392)	Serum alpha1-antitrypsin levels	HPOID:0006510	Chronic obstructive pulmonary disease	DOID:3083	chronic obstructive pulmonary disease	NA	NA	NA	NA	Chronic obstructive airway disease	NA	Research Support, N.I.H., Extramural	Research Support, Non-U.S. Gov't	Research Support, U.S. Gov't, Non-P.H.S.
7	67361027	rs6971526	C	T	rs6971526	23990791	2.74E-05	imputed, conditional on PI S and Z alleles in GWAS stage only	0.03	NA	1,392 European ancestry individuals	European(1392)	ALL(1392)	EUR(1392)	ALL(1392)	Serum alpha1-antitrypsin levels	HPOID:0006510	Chronic obstructive pulmonary disease	DOID:3083	chronic obstructive pulmonary disease	NA	NA	NA	NA	Chronic obstructive airway disease	NA	Research Support, N.I.H., Extramural	Research Support, Non-U.S. Gov't	Research Support, U.S. Gov't, Non-P.H.S.
7	71388850	rs11766496	G	C	rs11766496	22837378	2.00E-06	All	1.3	NA	up to 3,368 European ancestry cases; up to 29,507 European ancestry controls	European(32875)	ALL(32875)	EUR(32875)	ALL(32875)	Airflow obstruction	HPOID:0006536	Obstructive lung disease	DOID:3083	chronic obstructive pulmonary disease	D000402	Airway Obstruction	EFOID:0003892	pulmonary function measurement	Chronic obstructive airway disease	rs11766496-C	Research Support, N.I.H., Extramural	Meta-Analysis	Research Support, Non-U.S. Gov't
7	94054000	rs441051	T	C	rs441051	17903307	2.00E-06	NA	NA	NA	Up to 1,222 individuals	NOPOP(1222)	ALL(1222)	NOPOP(1222)	ALL(1222)	Mean forced vital capacity from 2 exams	HPOID:0006510	Chronic obstructive pulmonary disease	DOID:3083	chronic obstructive pulmonary disease	D008176	Lung Volume Measurements	NA	NA	Chronic obstructive airway disease	NA	Research Support, N.I.H., Extramural	Research Support, Non-U.S. Gov't	T
7	135771582	rs6944889	C	G	rs6944889	19300482	7.21E-05	NA	NA	NA	823 cases; 810 controls	NOPOP(1633)	ALL(1633)	NOPOP(1633)	ALL(1633)	Chronic obstructive pulmonary disease	HPOID:0006510	Chronic obstructive pulmonary disease	DOID:3083	chronic obstructive pulmonary disease	D029424	Pulmonary Disease, Chronic Obstructive	EFOID:0000341	chronic obstructive pulmonary disease	Chronic obstructive airway disease	NA	Research Support, N.I.H., Extramural	Research Support, U.S. Gov't, P.H.S.	Research Support, Non-U.S. Gov't
8	3778212	rs2912263	G	T	rs2912263	19300482	3.59E-05	NA	NA	NA	823 cases; 810 controls	NOPOP(1633)	ALL(1633)	NOPOP(1633)	ALL(1633)	Chronic obstructive pulmonary disease	HPOID:0006510	Chronic obstructive pulmonary disease	DOID:3083	chronic obstructive pulmonary disease	D029424	Pulmonary Disease, Chronic Obstructive	EFOID:0000341	chronic obstructive pulmonary disease	Chronic obstructive airway disease	NA	Research Support, N.I.H., Extramural	Research Support, U.S. Gov't, P.H.S.	Research Support, Non-U.S. Gov't
8	3828758	rs2688352	C	A	rs2688352	23990791	3.93E-05	imputed, conditional on PI S and Z alleles in GWAS stage only	0.03	NA	1,392 European ancestry individuals	European(1392)	ALL(1392)	EUR(1392)	ALL(1392)	Serum alpha1-antitrypsin levels	HPOID:0006510	Chronic obstructive pulmonary disease	DOID:3083	chronic obstructive pulmonary disease	NA	NA	NA	NA	Chronic obstructive airway disease	NA	Research Support, N.I.H., Extramural	Research Support, Non-U.S. Gov't	Research Support, U.S. Gov't, Non-P.H.S.
8	14687178	rs12681897	T	C	rs12681897	19300482	4.84E-05	NA	NA	NA	823 cases; 810 controls	NOPOP(1633)	ALL(1633)	NOPOP(1633)	ALL(1633)	Chronic obstructive pulmonary disease	HPOID:0006510	Chronic obstructive pulmonary disease	DOID:3083	chronic obstructive pulmonary disease	D029424	Pulmonary Disease, Chronic Obstructive	EFOID:0000341	chronic obstructive pulmonary disease	Chronic obstructive airway disease	NA	Research Support, N.I.H., Extramural	Research Support, U.S. Gov't, P.H.S.	Research Support, Non-U.S. Gov't
8	17964559	rs7844251	G	A	rs7844251	22837378	1.22E-09	NA	NA	NA	up to 3,368 European ancestry cases; up to 29,507 European ancestry controls	European(32875)	ALL(32875)	EUR(32875)	ALL(32875)	Airflow obstruction	HPOID:0006536	Obstructive lung disease	DOID:3083	chronic obstructive pulmonary disease	D000402	Airway Obstruction	EFOID:0003892	pulmonary function measurement	Chronic obstructive airway disease	NA	Research Support, N.I.H., Extramural	Meta-Analysis	Research Support, Non-U.S. Gov't
8	72270082	rs7006821	T	C	rs7006821	23144326	5.00E-06	IL8	NA	NA	Up to 1,951 European ancestry smokers	European(1951)	ALL(1951)	EUR(1951)	ALL(1951)	Chronic obstructive pulmonary disease-related biomarkers	HPOID:0006510	Chronic obstructive pulmonary disease	DOID:3083	chronic obstructive pulmonary disease	D029424	Pulmonary Disease, Chronic Obstructive	EFOID:0005080	surfactant protein D measurement	Chronic obstructive airway disease	rs7006821-C	Clinical Trial	Research Support, N.I.H., Extramural	Research Support, Non-U.S. Gov't
8	80553207	rs4739642	C	T	rs4739642	19300482	6.99E-05	NA	NA	NA	823 cases; 810 controls	NOPOP(1633)	ALL(1633)	NOPOP(1633)	ALL(1633)	Chronic obstructive pulmonary disease	HPOID:0006510	Chronic obstructive pulmonary disease	DOID:3083	chronic obstructive pulmonary disease	D029424	Pulmonary Disease, Chronic Obstructive	EFOID:0000341	chronic obstructive pulmonary disease	Chronic obstructive airway disease	NA	Research Support, N.I.H., Extramural	Research Support, U.S. Gov't, P.H.S.	Research Support, Non-U.S. Gov't
8	97522509	rs2589183	G	A	rs2589183	19300482	4.50E-05	NA	NA	NA	823 cases; 810 controls	NOPOP(1633)	ALL(1633)	NOPOP(1633)	ALL(1633)	Chronic obstructive pulmonary disease	HPOID:0006510	Chronic obstructive pulmonary disease	DOID:3083	chronic obstructive pulmonary disease	D029424	Pulmonary Disease, Chronic Obstructive	EFOID:0000341	chronic obstructive pulmonary disease	Chronic obstructive airway disease	NA	Research Support, N.I.H., Extramural	Research Support, U.S. Gov't, P.H.S.	Research Support, Non-U.S. Gov't
8	112607588	rs13279316	T	C	rs13279316	23990791	4.09E-05	imputed, conditional on PI S and Z alleles in GWAS stage only	0.03	NA	1,392 European ancestry individuals	European(1392)	ALL(1392)	EUR(1392)	ALL(1392)	Serum alpha1-antitrypsin levels	HPOID:0006510	Chronic obstructive pulmonary disease	DOID:3083	chronic obstructive pulmonary disease	NA	NA	NA	NA	Chronic obstructive airway disease	NA	Research Support, N.I.H., Extramural	Research Support, Non-U.S. Gov't	Research Support, U.S. Gov't, Non-P.H.S.
8	119830680	rs903614	A	C	rs903614	23144326	3.00E-06	IL8	NA	NA	Up to 1,951 European ancestry smokers	European(1951)	ALL(1951)	EUR(1951)	ALL(1951)	Chronic obstructive pulmonary disease-related biomarkers	HPOID:0006510	Chronic obstructive pulmonary disease	DOID:3083	chronic obstructive pulmonary disease	D029424	Pulmonary Disease, Chronic Obstructive	EFOID:0005080	surfactant protein D measurement	Chronic obstructive airway disease	rs903614-C	Clinical Trial	Research Support, N.I.H., Extramural	Research Support, Non-U.S. Gov't
9	9910123	rs10759102	G	A	rs10759102	22837378	1.00E-06	FEV1 65%	1.23	NA	up to 3,368 European ancestry cases; up to 29,507 European ancestry controls	European(32875)	ALL(32875)	EUR(32875)	ALL(32875)	Airflow obstruction	HPOID:0006536	Obstructive lung disease	DOID:3083	chronic obstructive pulmonary disease	D000402	Airway Obstruction	EFOID:0003892	pulmonary function measurement	Chronic obstructive airway disease	NA	Research Support, N.I.H., Extramural	Meta-Analysis	Research Support, Non-U.S. Gov't
9	26580067	rs996414	G	A	rs996414	21921092	8.76E-07	Chronic obstructive pulmonary disease (COPD)	NA	NA	58 Costa Rica descent cases; 57 Costa Rica descent controls	Costa Rica(115)	ALL(115)	HIS(115)	ALL(115)	chronic obstructive pulmonary disease	HPOID:0006510	Chronic obstructive pulmonary disease	DOID:3083	chronic obstructive pulmonary disease	D029424	Pulmonary Disease, Chronic Obstructive	EFOID:0000341	chronic obstructive pulmonary disease	Chronic obstructive airway disease	NA	Research Support, N.I.H., Extramural	Research Support, Non-U.S. Gov't	T
9	104218656	rs10989511	A	G	rs10989511	19300482	7.27E-05	NA	NA	NA	823 cases; 810 controls	NOPOP(1633)	ALL(1633)	NOPOP(1633)	ALL(1633)	Chronic obstructive pulmonary disease	HPOID:0006510	Chronic obstructive pulmonary disease	DOID:3083	chronic obstructive pulmonary disease	D029424	Pulmonary Disease, Chronic Obstructive	EFOID:0000341	chronic obstructive pulmonary disease	Chronic obstructive airway disease	NA	Research Support, N.I.H., Extramural	Research Support, U.S. Gov't, P.H.S.	Research Support, Non-U.S. Gov't
9	137928371	rs4842213	T	A	rs4842213	19300482	3.77E-05	NA	NA	NA	823 cases; 810 controls	NOPOP(1633)	ALL(1633)	NOPOP(1633)	ALL(1633)	Chronic obstructive pulmonary disease	HPOID:0006510	Chronic obstructive pulmonary disease	DOID:3083	chronic obstructive pulmonary disease	D029424	Pulmonary Disease, Chronic Obstructive	EFOID:0000341	chronic obstructive pulmonary disease	Chronic obstructive airway disease	NA	Research Support, N.I.H., Extramural	Research Support, U.S. Gov't, P.H.S.	Research Support, Non-U.S. Gov't
10	8040431	rs11593082	T	C	rs11593082	23990791	3.69E-05	imputed, conditional on PI S and Z alleles in GWAS stage only	0.05	NA	1,392 European ancestry individuals	European(1392)	ALL(1392)	EUR(1392)	ALL(1392)	Serum alpha1-antitrypsin levels	HPOID:0006510	Chronic obstructive pulmonary disease	DOID:3083	chronic obstructive pulmonary disease	NA	NA	NA	NA	Chronic obstructive airway disease	NA	Research Support, N.I.H., Extramural	Research Support, Non-U.S. Gov't	Research Support, U.S. Gov't, Non-P.H.S.
10	28748824	rs12762979	G	A	rs12762979	19300482	4.59E-05	NA	NA	NA	823 cases; 810 controls	NOPOP(1633)	ALL(1633)	NOPOP(1633)	ALL(1633)	Chronic obstructive pulmonary disease	HPOID:0006510	Chronic obstructive pulmonary disease	DOID:3083	chronic obstructive pulmonary disease	D029424	Pulmonary Disease, Chronic Obstructive	EFOID:0000341	chronic obstructive pulmonary disease	Chronic obstructive airway disease	NA	Research Support, N.I.H., Extramural	Research Support, U.S. Gov't, P.H.S.	Research Support, Non-U.S. Gov't
10	43821380	rs2460535	C	T	rs2460535	23990791	3.95E-05	imputed, conditional on PI S and Z alleles in GWAS stage only	0.05	NA	1,392 European ancestry individuals	European(1392)	ALL(1392)	EUR(1392)	ALL(1392)	Serum alpha1-antitrypsin levels	HPOID:0006510	Chronic obstructive pulmonary disease	DOID:3083	chronic obstructive pulmonary disease	NA	NA	NA	NA	Chronic obstructive airway disease	NA	Research Support, N.I.H., Extramural	Research Support, Non-U.S. Gov't	Research Support, U.S. Gov't, Non-P.H.S.
10	59677013	rs12772513	C	A	rs12772513	19300482	6.08E-05	NA	NA	NA	823 cases; 810 controls	NOPOP(1633)	ALL(1633)	NOPOP(1633)	ALL(1633)	Chronic obstructive pulmonary disease	HPOID:0006510	Chronic obstructive pulmonary disease	DOID:3083	chronic obstructive pulmonary disease	D029424	Pulmonary Disease, Chronic Obstructive	EFOID:0000341	chronic obstructive pulmonary disease	Chronic obstructive airway disease	NA	Research Support, N.I.H., Extramural	Research Support, U.S. Gov't, P.H.S.	Research Support, Non-U.S. Gov't
10	62826952	rs7922793	C	T	rs7922793	22986903	0.0000023	NA	NA	NA	4,048 European ancestry cases	European(4048)	ALL(4048)	EUR(4048)	ALL(4048)	Chronic obstructive pulmonary disease (moderate to severe)	HPOID:0006510	Chronic obstructive pulmonary disease	DOID:3083	chronic obstructive pulmonary disease	NA	NA	NA	NA	Chronic obstructive airway disease	NA	Multicenter Study	Research Support, N.I.H., Extramural	Research Support, Non-U.S. Gov't
10	62906955	rs10761570	T	G	rs10761570	22986903	0.00000006	NA	NA	NA	4,048 European ancestry cases	European(4048)	ALL(4048)	EUR(4048)	ALL(4048)	Chronic obstructive pulmonary disease (moderate to severe)	HPOID:0006510	Chronic obstructive pulmonary disease	DOID:3083	chronic obstructive pulmonary disease	NA	NA	NA	NA	Chronic obstructive airway disease	NA	Multicenter Study	Research Support, N.I.H., Extramural	Research Support, Non-U.S. Gov't
10	62907028	rs10761571	A	C	rs10761571	22986903	0.000000037	NA	NA	NA	4,048 European ancestry cases	European(4048)	ALL(4048)	EUR(4048)	ALL(4048)	Chronic obstructive pulmonary disease (moderate to severe)	HPOID:0006510	Chronic obstructive pulmonary disease	DOID:3083	chronic obstructive pulmonary disease	NA	NA	NA	NA	Chronic obstructive airway disease	NA	Multicenter Study	Research Support, N.I.H., Extramural	Research Support, Non-U.S. Gov't
10	62907185	rs7896712	T	A	rs7896712	22986903	0.000000037	NA	NA	NA	4,048 European ancestry cases	European(4048)	ALL(4048)	EUR(4048)	ALL(4048)	Chronic obstructive pulmonary disease (moderate to severe)	HPOID:0006510	Chronic obstructive pulmonary disease	DOID:3083	chronic obstructive pulmonary disease	NA	NA	NA	NA	Chronic obstructive airway disease	NA	Multicenter Study	Research Support, N.I.H., Extramural	Research Support, Non-U.S. Gov't
10	62907226	rs7911302	A	C,G,T	rs7911302	22986903	0.000000044	NA	NA	NA	4,048 European ancestry cases	European(4048)	ALL(4048)	EUR(4048)	ALL(4048)	Chronic obstructive pulmonary disease (moderate to severe)	HPOID:0006510	Chronic obstructive pulmonary disease	DOID:3083	chronic obstructive pulmonary disease	NA	NA	NA	NA	Chronic obstructive airway disease	NA	Multicenter Study	Research Support, N.I.H., Extramural	Research Support, Non-U.S. Gov't
10	62929997	rs4948444	G	A	rs4948444	22986903	0.00000036	NA	NA	NA	4,048 European ancestry cases	European(4048)	ALL(4048)	EUR(4048)	ALL(4048)	Chronic obstructive pulmonary disease (moderate to severe)	HPOID:0006510	Chronic obstructive pulmonary disease	DOID:3083	chronic obstructive pulmonary disease	NA	NA	NA	NA	Chronic obstructive airway disease	NA	Multicenter Study	Research Support, N.I.H., Extramural	Research Support, Non-U.S. Gov't
10	81694950	rs1923539	G	A	rs1923539	23144326	5.00E-09	SP-D	NA	NA	Up to 1,951 European ancestry smokers	European(1951)	ALL(1951)	EUR(1951)	ALL(1951)	Chronic obstructive pulmonary disease-related biomarkers	HPOID:0006510	Chronic obstructive pulmonary disease	DOID:3083	chronic obstructive pulmonary disease	D029424	Pulmonary Disease, Chronic Obstructive	EFOID:0005080	surfactant protein D measurement	Chronic obstructive airway disease	rs1923539-A	Clinical Trial	Research Support, N.I.H., Extramural	Research Support, Non-U.S. Gov't
10	81705433	rs7078012	C	T	rs7078012	23144326	5.00E-09	SP-D	NA	NA	Up to 1,951 European ancestry smokers	European(1951)	ALL(1951)	EUR(1951)	ALL(1951)	Chronic obstructive pulmonary disease-related biomarkers	HPOID:0006510	Chronic obstructive pulmonary disease	DOID:3083	chronic obstructive pulmonary disease	D029424	Pulmonary Disease, Chronic Obstructive	EFOID:0005080	surfactant protein D measurement	Chronic obstructive airway disease	rs7078012-T	Clinical Trial	Research Support, N.I.H., Extramural	Research Support, Non-U.S. Gov't
10	81735981	rs3923564	A	G	rs3923564	23144326	2.00E-27	SP-D	NA	NA	Up to 1,951 European ancestry smokers	European(1951)	ALL(1951)	EUR(1951)	ALL(1951)	Chronic obstructive pulmonary disease-related biomarkers	HPOID:0006510	Chronic obstructive pulmonary disease	DOID:3083	chronic obstructive pulmonary disease	D029424	Pulmonary Disease, Chronic Obstructive	EFOID:0005080	surfactant protein D measurement	Chronic obstructive airway disease	rs3923564-G	Clinical Trial	Research Support, N.I.H., Extramural	Research Support, Non-U.S. Gov't
10	81788104	rs12220777	T	C	rs12220777	23144326	7.00E-11	SP-D	NA	NA	Up to 1,951 European ancestry smokers	European(1951)	ALL(1951)	EUR(1951)	ALL(1951)	Chronic obstructive pulmonary disease-related biomarkers	HPOID:0006510	Chronic obstructive pulmonary disease	DOID:3083	chronic obstructive pulmonary disease	D029424	Pulmonary Disease, Chronic Obstructive	EFOID:0005080	surfactant protein D measurement	Chronic obstructive airway disease	rs12220777-C	Clinical Trial	Research Support, N.I.H., Extramural	Research Support, Non-U.S. Gov't
10	81847914	rs728616	G	T	rs728616	23144326	2.00E-12	SP-D	NA	NA	Up to 1,951 European ancestry smokers	European(1951)	ALL(1951)	EUR(1951)	ALL(1951)	Chronic obstructive pulmonary disease-related biomarkers	HPOID:0006510	Chronic obstructive pulmonary disease	DOID:3083	chronic obstructive pulmonary disease	D029424	Pulmonary Disease, Chronic Obstructive	EFOID:0005080	surfactant protein D measurement	Chronic obstructive airway disease	rs728616-T	Clinical Trial	Research Support, N.I.H., Extramural	Research Support, Non-U.S. Gov't
10	81882370	rs3851050	T	C	rs3851050	23144326	1.00E-11	SP-D	NA	NA	Up to 1,951 European ancestry smokers	European(1951)	ALL(1951)	EUR(1951)	ALL(1951)	Chronic obstructive pulmonary disease-related biomarkers	HPOID:0006510	Chronic obstructive pulmonary disease	DOID:3083	chronic obstructive pulmonary disease	D029424	Pulmonary Disease, Chronic Obstructive	EFOID:0005080	surfactant protein D measurement	Chronic obstructive airway disease	rs3851050-C	Clinical Trial	Research Support, N.I.H., Extramural	Research Support, Non-U.S. Gov't
10	81933748	rs6585424	A	G	rs6585424	23144326	1.00E-10	SP-D	NA	NA	Up to 1,951 European ancestry smokers	European(1951)	ALL(1951)	EUR(1951)	ALL(1951)	Chronic obstructive pulmonary disease-related biomarkers	HPOID:0006510	Chronic obstructive pulmonary disease	DOID:3083	chronic obstructive pulmonary disease	D029424	Pulmonary Disease, Chronic Obstructive	EFOID:0005080	surfactant protein D measurement	Chronic obstructive airway disease	rs6585424-G	Clinical Trial	Research Support, N.I.H., Extramural	Research Support, Non-U.S. Gov't
10	94168797	rs2263638	G	A	rs2263638	22837378	3.00E-06	Never smoker	1.28	NA	up to 3,368 European ancestry cases; up to 29,507 European ancestry controls	European(32875)	ALL(32875)	EUR(32875)	ALL(32875)	Airflow obstruction	HPOID:0006536	Obstructive lung disease	DOID:3083	chronic obstructive pulmonary disease	D000402	Airway Obstruction	EFOID:0003892	pulmonary function measurement	Chronic obstructive airway disease	NA	Research Support, N.I.H., Extramural	Meta-Analysis	Research Support, Non-U.S. Gov't
10	96058636	rs117607728	G	T	rs117607728	21685187	4.00E-07	Lifetime average CPD	3	NA	3,441 Caucasian ever-smokers with COPD	Caucasian(3441)	ALL(3441)	EUR(3441)	ALL(3441)	Chronic obstructive pulmonary disease	HPOID:0006510	Chronic obstructive pulmonary disease	DOID:3083	chronic obstructive pulmonary disease	D029424	Pulmonary Disease, Chronic Obstructive	EFOID:0000341	chronic obstructive pulmonary disease	Chronic obstructive airway disease	rs117607728-G	Randomized Controlled Trial	Multicenter Study	Research Support, N.I.H., Extramural
10	119379656	rs181654	A	G	rs181654	22837378	1.00E-07	no asthma	0.81	NA	up to 3,368 European ancestry cases; up to 29,507 European ancestry controls	European(32875)	ALL(32875)	EUR(32875)	ALL(32875)	Airflow obstruction	HPOID:0006536	Obstructive lung disease	DOID:3083	chronic obstructive pulmonary disease	D000402	Airway Obstruction	EFOID:0003892	pulmonary function measurement	Chronic obstructive airway disease	NA	Research Support, N.I.H., Extramural	Meta-Analysis	Research Support, Non-U.S. Gov't
10	133957761	rs954820	G	A	rs954820	23144326	4.00E-06	IL6	NA	NA	Up to 1,951 European ancestry smokers	European(1951)	ALL(1951)	EUR(1951)	ALL(1951)	Chronic obstructive pulmonary disease-related biomarkers	HPOID:0006510	Chronic obstructive pulmonary disease	DOID:3083	chronic obstructive pulmonary disease	D029424	Pulmonary Disease, Chronic Obstructive	EFOID:0005080	surfactant protein D measurement	Chronic obstructive airway disease	rs954820-C	Clinical Trial	Research Support, N.I.H., Extramural	Research Support, Non-U.S. Gov't
11	7642031	rs10769813	G	A	rs10769813	19300482	8.54E-05	NA	NA	NA	823 cases; 810 controls	NOPOP(1633)	ALL(1633)	NOPOP(1633)	ALL(1633)	Chronic obstructive pulmonary disease	HPOID:0006510	Chronic obstructive pulmonary disease	DOID:3083	chronic obstructive pulmonary disease	D029424	Pulmonary Disease, Chronic Obstructive	EFOID:0000341	chronic obstructive pulmonary disease	Chronic obstructive airway disease	NA	Research Support, N.I.H., Extramural	Research Support, U.S. Gov't, P.H.S.	Research Support, Non-U.S. Gov't
11	34805849	rs7929679	A	G	rs7929679	23144326	7.00E-09	CC16	NA	NA	Up to 1,951 European ancestry smokers	European(1951)	ALL(1951)	EUR(1951)	ALL(1951)	Chronic obstructive pulmonary disease-related biomarkers	HPOID:0006510	Chronic obstructive pulmonary disease	DOID:3083	chronic obstructive pulmonary disease	D029424	Pulmonary Disease, Chronic Obstructive	EFOID:0005080	surfactant protein D measurement	Chronic obstructive airway disease	rs7929679-G	Clinical Trial	Research Support, N.I.H., Extramural	Research Support, Non-U.S. Gov't
11	62103420	rs2463822	T	C	rs2463822	23144326	1.00E-10	CC16	NA	NA	Up to 1,951 European ancestry smokers	European(1951)	ALL(1951)	EUR(1951)	ALL(1951)	Chronic obstructive pulmonary disease-related biomarkers	HPOID:0006510	Chronic obstructive pulmonary disease	DOID:3083	chronic obstructive pulmonary disease	D029424	Pulmonary Disease, Chronic Obstructive	EFOID:0005080	surfactant protein D measurement	Chronic obstructive airway disease	rs2463822-T	Clinical Trial	Research Support, N.I.H., Extramural	Research Support, Non-U.S. Gov't
11	62186542	rs3741240	G	A	rs3741240	23144326	1.00E-26	CC16	NA	NA	Up to 1,951 European ancestry smokers	European(1951)	ALL(1951)	EUR(1951)	ALL(1951)	Chronic obstructive pulmonary disease-related biomarkers	HPOID:0006510	Chronic obstructive pulmonary disease	DOID:3083	chronic obstructive pulmonary disease	D029424	Pulmonary Disease, Chronic Obstructive	EFOID:0005080	surfactant protein D measurement	Chronic obstructive airway disease	rs3741240-A	Clinical Trial	Research Support, N.I.H., Extramural	Research Support, Non-U.S. Gov't
11	62197427	rs2077224	C	A	rs2077224	23144326	2.00E-14	CC16	NA	NA	Up to 1,951 European ancestry smokers	European(1951)	ALL(1951)	EUR(1951)	ALL(1951)	Chronic obstructive pulmonary disease-related biomarkers	HPOID:0006510	Chronic obstructive pulmonary disease	DOID:3083	chronic obstructive pulmonary disease	D029424	Pulmonary Disease, Chronic Obstructive	EFOID:0005080	surfactant protein D measurement	Chronic obstructive airway disease	rs2077224-A	Clinical Trial	Research Support, N.I.H., Extramural	Research Support, Non-U.S. Gov't
11	62199817	rs17157266	T	C	rs17157266	23144326	1.00E-09	CC16	NA	NA	Up to 1,951 European ancestry smokers	European(1951)	ALL(1951)	EUR(1951)	ALL(1951)	Chronic obstructive pulmonary disease-related biomarkers	HPOID:0006510	Chronic obstructive pulmonary disease	DOID:3083	chronic obstructive pulmonary disease	D029424	Pulmonary Disease, Chronic Obstructive	EFOID:0005080	surfactant protein D measurement	Chronic obstructive airway disease	rs17157266-C	Clinical Trial	Research Support, N.I.H., Extramural	Research Support, Non-U.S. Gov't
11	92668826	rs3847554	C	T	rs3847554	19300482	9.03E-05	NA	NA	NA	823 cases; 810 controls	NOPOP(1633)	ALL(1633)	NOPOP(1633)	ALL(1633)	Chronic obstructive pulmonary disease	HPOID:0006510	Chronic obstructive pulmonary disease	DOID:3083	chronic obstructive pulmonary disease	D029424	Pulmonary Disease, Chronic Obstructive	EFOID:0000341	chronic obstructive pulmonary disease	Chronic obstructive airway disease	NA	Research Support, N.I.H., Extramural	Research Support, U.S. Gov't, P.H.S.	Research Support, Non-U.S. Gov't
11	99090508	rs4754595	A	G	rs4754595	19300482	4.90E-05	NA	NA	NA	823 cases; 810 controls	NOPOP(1633)	ALL(1633)	NOPOP(1633)	ALL(1633)	Chronic obstructive pulmonary disease	HPOID:0006510	Chronic obstructive pulmonary disease	DOID:3083	chronic obstructive pulmonary disease	D029424	Pulmonary Disease, Chronic Obstructive	EFOID:0000341	chronic obstructive pulmonary disease	Chronic obstructive airway disease	NA	Research Support, N.I.H., Extramural	Research Support, U.S. Gov't, P.H.S.	Research Support, Non-U.S. Gov't
11	99154402	rs12421122	C	T	rs12421122	19300482	3.52E-05	NA	NA	NA	823 cases; 810 controls	NOPOP(1633)	ALL(1633)	NOPOP(1633)	ALL(1633)	Chronic obstructive pulmonary disease	HPOID:0006510	Chronic obstructive pulmonary disease	DOID:3083	chronic obstructive pulmonary disease	D029424	Pulmonary Disease, Chronic Obstructive	EFOID:0000341	chronic obstructive pulmonary disease	Chronic obstructive airway disease	NA	Research Support, N.I.H., Extramural	Research Support, U.S. Gov't, P.H.S.	Research Support, Non-U.S. Gov't
11	99165666	rs12577504	C	T	rs12577504	19300482	8.16E-05	NA	NA	NA	823 cases; 810 controls	NOPOP(1633)	ALL(1633)	NOPOP(1633)	ALL(1633)	Chronic obstructive pulmonary disease	HPOID:0006510	Chronic obstructive pulmonary disease	DOID:3083	chronic obstructive pulmonary disease	D029424	Pulmonary Disease, Chronic Obstructive	EFOID:0000341	chronic obstructive pulmonary disease	Chronic obstructive airway disease	NA	Research Support, N.I.H., Extramural	Research Support, U.S. Gov't, P.H.S.	Research Support, Non-U.S. Gov't
11	99191617	rs12576370	C	T	rs12576370	19300482	7.59E-05	NA	NA	NA	823 cases; 810 controls	NOPOP(1633)	ALL(1633)	NOPOP(1633)	ALL(1633)	Chronic obstructive pulmonary disease	HPOID:0006510	Chronic obstructive pulmonary disease	DOID:3083	chronic obstructive pulmonary disease	D029424	Pulmonary Disease, Chronic Obstructive	EFOID:0000341	chronic obstructive pulmonary disease	Chronic obstructive airway disease	NA	Research Support, N.I.H., Extramural	Research Support, U.S. Gov't, P.H.S.	Research Support, Non-U.S. Gov't
11	99257825	rs11219732	C	T	rs11219732	19300482	4.47E-06	NA	NA	NA	823 cases; 810 controls	NOPOP(1633)	ALL(1633)	NOPOP(1633)	ALL(1633)	Chronic obstructive pulmonary disease	HPOID:0006510	Chronic obstructive pulmonary disease	DOID:3083	chronic obstructive pulmonary disease	D029424	Pulmonary Disease, Chronic Obstructive	EFOID:0000341	chronic obstructive pulmonary disease	Chronic obstructive airway disease	NA	Research Support, N.I.H., Extramural	Research Support, U.S. Gov't, P.H.S.	Research Support, Non-U.S. Gov't
11	102720945	rs626750	G	A	rs626750	24621683	3.00E-09	NA	NA	NA	3,145 European ancestry cases; 3,955 European ancestry controls; 352 African American cases; 1,749 African American controls	African American(2101)	European(7100)	ALL(9201)	AFR(2101)	EUR(7100)	ALL(9201)	Chronic obstructive pulmonary disease (severe)	HPOID:0006510	Chronic obstructive pulmonary disease	DOID:3083	chronic obstructive pulmonary disease	NA	NA	NA	NA	Chronic obstructive airway disease	rs626750-G	Research Support, N.I.H., Extramural
11	120408071	rs3901366	G	A	rs3901366	19300482	1.21E-05	NA	NA	NA	823 cases; 810 controls	NOPOP(1633)	ALL(1633)	NOPOP(1633)	ALL(1633)	Chronic obstructive pulmonary disease	HPOID:0006510	Chronic obstructive pulmonary disease	DOID:3083	chronic obstructive pulmonary disease	D029424	Pulmonary Disease, Chronic Obstructive	EFOID:0000341	chronic obstructive pulmonary disease	Chronic obstructive airway disease	NA	Research Support, N.I.H., Extramural	Research Support, U.S. Gov't, P.H.S.	Research Support, Non-U.S. Gov't
11	120412169	rs2253023	C	T	rs2253023	19300482	2.46E-05	NA	NA	NA	823 cases; 810 controls	NOPOP(1633)	ALL(1633)	NOPOP(1633)	ALL(1633)	Chronic obstructive pulmonary disease	HPOID:0006510	Chronic obstructive pulmonary disease	DOID:3083	chronic obstructive pulmonary disease	D029424	Pulmonary Disease, Chronic Obstructive	EFOID:0000341	chronic obstructive pulmonary disease	Chronic obstructive airway disease	NA	Research Support, N.I.H., Extramural	Research Support, U.S. Gov't, P.H.S.	Research Support, Non-U.S. Gov't
11	120426966	rs2248540	T	C	rs2248540	19300482	6.99E-06	NA	NA	NA	823 cases; 810 controls	NOPOP(1633)	ALL(1633)	NOPOP(1633)	ALL(1633)	Chronic obstructive pulmonary disease	HPOID:0006510	Chronic obstructive pulmonary disease	DOID:3083	chronic obstructive pulmonary disease	D029424	Pulmonary Disease, Chronic Obstructive	EFOID:0000341	chronic obstructive pulmonary disease	Chronic obstructive airway disease	NA	Research Support, N.I.H., Extramural	Research Support, U.S. Gov't, P.H.S.	Research Support, Non-U.S. Gov't
11	120446830	rs12796185	T	C	rs12796185	19300482	1.79E-05	NA	NA	NA	823 cases; 810 controls	NOPOP(1633)	ALL(1633)	NOPOP(1633)	ALL(1633)	Chronic obstructive pulmonary disease	HPOID:0006510	Chronic obstructive pulmonary disease	DOID:3083	chronic obstructive pulmonary disease	D029424	Pulmonary Disease, Chronic Obstructive	EFOID:0000341	chronic obstructive pulmonary disease	Chronic obstructive airway disease	NA	Research Support, N.I.H., Extramural	Research Support, U.S. Gov't, P.H.S.	Research Support, Non-U.S. Gov't
11	120468752	rs7105963	C	T	rs7105963	19300482	9.90E-05	NA	NA	NA	823 cases; 810 controls	NOPOP(1633)	ALL(1633)	NOPOP(1633)	ALL(1633)	Chronic obstructive pulmonary disease	HPOID:0006510	Chronic obstructive pulmonary disease	DOID:3083	chronic obstructive pulmonary disease	D029424	Pulmonary Disease, Chronic Obstructive	EFOID:0000341	chronic obstructive pulmonary disease	Chronic obstructive airway disease	NA	Research Support, N.I.H., Extramural	Research Support, U.S. Gov't, P.H.S.	Research Support, Non-U.S. Gov't
11	120483858	rs11603831	C	T	rs11603831	19300482	2.83E-06	NA	NA	NA	823 cases; 810 controls	NOPOP(1633)	ALL(1633)	NOPOP(1633)	ALL(1633)	Chronic obstructive pulmonary disease	HPOID:0006510	Chronic obstructive pulmonary disease	DOID:3083	chronic obstructive pulmonary disease	D029424	Pulmonary Disease, Chronic Obstructive	EFOID:0000341	chronic obstructive pulmonary disease	Chronic obstructive airway disease	NA	Research Support, N.I.H., Extramural	Research Support, U.S. Gov't, P.H.S.	Research Support, Non-U.S. Gov't
11	132010117	rs4468361	T	C	rs4468361	23144326	8.00E-06	TNFA	NA	NA	Up to 1,951 European ancestry smokers	European(1951)	ALL(1951)	EUR(1951)	ALL(1951)	Chronic obstructive pulmonary disease-related biomarkers	HPOID:0006510	Chronic obstructive pulmonary disease	DOID:3083	chronic obstructive pulmonary disease	D029424	Pulmonary Disease, Chronic Obstructive	EFOID:0005080	surfactant protein D measurement	Chronic obstructive airway disease	rs4468361-T	Clinical Trial	Research Support, N.I.H., Extramural	Research Support, Non-U.S. Gov't
12	4139900	rs7300338	C	T	rs7300338	23990791	1.61E-05	imputed, conditional on PI S and Z alleles in GWAS stage only	0.03	NA	1,392 European ancestry individuals	European(1392)	ALL(1392)	EUR(1392)	ALL(1392)	Serum alpha1-antitrypsin levels	HPOID:0006510	Chronic obstructive pulmonary disease	DOID:3083	chronic obstructive pulmonary disease	NA	NA	NA	NA	Chronic obstructive airway disease	NA	Research Support, N.I.H., Extramural	Research Support, Non-U.S. Gov't	Research Support, U.S. Gov't, Non-P.H.S.
12	16942935	rs2129818	G	T	rs2129818	23990791	4.28E-05	imputed, conditional on PI S and Z alleles in GWAS stage only	0.03	NA	1,392 European ancestry individuals	European(1392)	ALL(1392)	EUR(1392)	ALL(1392)	Serum alpha1-antitrypsin levels	HPOID:0006510	Chronic obstructive pulmonary disease	DOID:3083	chronic obstructive pulmonary disease	NA	NA	NA	NA	Chronic obstructive airway disease	NA	Research Support, N.I.H., Extramural	Research Support, Non-U.S. Gov't	Research Support, U.S. Gov't, Non-P.H.S.
12	16956601	rs1386819	A	G	rs1386819	23990791	4.72E-05	imputed, conditional on PI S and Z alleles in GWAS stage only	0.03	NA	1,392 European ancestry individuals	European(1392)	ALL(1392)	EUR(1392)	ALL(1392)	Serum alpha1-antitrypsin levels	HPOID:0006510	Chronic obstructive pulmonary disease	DOID:3083	chronic obstructive pulmonary disease	NA	NA	NA	NA	Chronic obstructive airway disease	NA	Research Support, N.I.H., Extramural	Research Support, Non-U.S. Gov't	Research Support, U.S. Gov't, Non-P.H.S.
12	62386600	rs11174267	A	G	rs11174267	24621683	8.00E-07	(AA)	NA	NA	5,812 European ancestry cases; 3,955 European ancestry controls; 821 African American cases; 1,749 African American controls	African American(2570)	European(9767)	ALL(12337)	AFR(2570)	EUR(9767)	ALL(12337)	Chronic obstructive pulmonary disease (moderate to severe)	HPOID:0006510	Chronic obstructive pulmonary disease	DOID:3083	chronic obstructive pulmonary disease	NA	NA	NA	NA	Chronic obstructive airway disease	NA	Research Support, N.I.H., Extramural
12	96260474	rs7957346	C	A	rs7957346	24383474	2.20E-08	NA	0.06	[0.0354-0.0746] unit decrease	2,587 European ancestry individuals; 2,510 African American individuals; 2,113 Hispanic individuals; 704 Chinese ancestry individuals	Chinese(704)	African American(2510)	European(2587)	Hispanic(2113)	ALL(7914)	ASN(704)	HIS(2113)	AFR(2510)	EUR(2587)	ALL(7914)	Pulmonary emphysema	HPOID:0006510	Chronic obstructive pulmonary disease	DOID:9675	pulmonary emphysema	NA	NA	NA
12	100578633	rs10778044	C	T	rs10778044	22837378	1.19E-08	NA	NA	NA	up to 3,368 European ancestry cases; up to 29,507 European ancestry controls	European(32875)	ALL(32875)	EUR(32875)	ALL(32875)	Airflow obstruction	HPOID:0006536	Obstructive lung disease	DOID:3083	chronic obstructive pulmonary disease	D000402	Airway Obstruction	EFOID:0003892	pulmonary function measurement	Chronic obstructive airway disease	NA	Research Support, N.I.H., Extramural	Meta-Analysis	Research Support, Non-U.S. Gov't
12	104248696	rs11111814	T	C	rs11111814	22837378	9.24E-10	NA	NA	NA	up to 3,368 European ancestry cases; up to 29,507 European ancestry controls	European(32875)	ALL(32875)	EUR(32875)	ALL(32875)	Airflow obstruction	HPOID:0006536	Obstructive lung disease	DOID:3083	chronic obstructive pulmonary disease	D000402	Airway Obstruction	EFOID:0003892	pulmonary function measurement	Chronic obstructive airway disease	NA	Research Support, N.I.H., Extramural	Meta-Analysis	Research Support, Non-U.S. Gov't
12	105670337	rs10861369	C	T	rs10861369	19300482	9.39E-05	NA	NA	NA	823 cases; 810 controls	NOPOP(1633)	ALL(1633)	NOPOP(1633)	ALL(1633)	Chronic obstructive pulmonary disease	HPOID:0006510	Chronic obstructive pulmonary disease	DOID:3083	chronic obstructive pulmonary disease	D029424	Pulmonary Disease, Chronic Obstructive	EFOID:0000341	chronic obstructive pulmonary disease	Chronic obstructive airway disease	NA	Research Support, N.I.H., Extramural	Research Support, U.S. Gov't, P.H.S.	Research Support, Non-U.S. Gov't
12	114637848	rs4767234	A	C	rs4767234	22837378	6.00E-07	Smoker	1.17	NA	up to 3,368 European ancestry cases; up to 29,507 European ancestry controls	European(32875)	ALL(32875)	EUR(32875)	ALL(32875)	Airflow obstruction	HPOID:0006536	Obstructive lung disease	DOID:3083	chronic obstructive pulmonary disease	D000402	Airway Obstruction	EFOID:0003892	pulmonary function measurement	Chronic obstructive airway disease	rs4767234-A	Research Support, N.I.H., Extramural	Meta-Analysis	Research Support, Non-U.S. Gov't
12	121403724	rs7953249	G	A	rs7953249	23144326	1.00E-06	CRP	NA	NA	Up to 1,951 European ancestry smokers	European(1951)	ALL(1951)	EUR(1951)	ALL(1951)	Chronic obstructive pulmonary disease-related biomarkers	HPOID:0006510	Chronic obstructive pulmonary disease	DOID:3083	chronic obstructive pulmonary disease	D029424	Pulmonary Disease, Chronic Obstructive	EFOID:0005080	surfactant protein D measurement	Chronic obstructive airway disease	rs7953249-G	Clinical Trial	Research Support, N.I.H., Extramural	Research Support, Non-U.S. Gov't
12	121622304	rs3751143	A	C	rs3751143	23144326	4.00E-06	IL8	NA	NA	Up to 1,951 European ancestry smokers	European(1951)	ALL(1951)	EUR(1951)	ALL(1951)	Chronic obstructive pulmonary disease-related biomarkers	HPOID:0006510	Chronic obstructive pulmonary disease	DOID:3083	chronic obstructive pulmonary disease	D029424	Pulmonary Disease, Chronic Obstructive	EFOID:0005080	surfactant protein D measurement	Chronic obstructive airway disease	rs3751143-C	Clinical Trial	Research Support, N.I.H., Extramural	Research Support, Non-U.S. Gov't
12	129894564	rs2030436	A	G	rs2030436	22986903	0.00000032	NA	NA	NA	4,048 European ancestry cases	European(4048)	ALL(4048)	EUR(4048)	ALL(4048)	Chronic obstructive pulmonary disease (moderate to severe)	HPOID:0006510	Chronic obstructive pulmonary disease	DOID:3083	chronic obstructive pulmonary disease	NA	NA	NA	NA	Chronic obstructive airway disease	NA	Multicenter Study	Research Support, N.I.H., Extramural	Research Support, Non-U.S. Gov't
13	24666535	rs8002029	A	G	rs8002029	23990791	4.65E-05	imputed, conditional on PI S and Z alleles in GWAS stage only	0.05	NA	1,392 European ancestry individuals	European(1392)	ALL(1392)	EUR(1392)	ALL(1392)	Serum alpha1-antitrypsin levels	HPOID:0006510	Chronic obstructive pulmonary disease	DOID:3083	chronic obstructive pulmonary disease	NA	NA	NA	NA	Chronic obstructive airway disease	NA	Research Support, N.I.H., Extramural	Research Support, Non-U.S. Gov't	Research Support, U.S. Gov't, Non-P.H.S.
13	24666571	rs7984719	T	C	rs7984719	23990791	4.73E-05	imputed, conditional on PI S and Z alleles in GWAS stage only	0.05	NA	1,392 European ancestry individuals	European(1392)	ALL(1392)	EUR(1392)	ALL(1392)	Serum alpha1-antitrypsin levels	HPOID:0006510	Chronic obstructive pulmonary disease	DOID:3083	chronic obstructive pulmonary disease	NA	NA	NA	NA	Chronic obstructive airway disease	NA	Research Support, N.I.H., Extramural	Research Support, Non-U.S. Gov't	Research Support, U.S. Gov't, Non-P.H.S.
13	24666937	rs9511045	G	A	rs9511045	23990791	1.44E-05	imputed, conditional on PI S and Z alleles in GWAS stage only	0.04	NA	1,392 European ancestry individuals	European(1392)	ALL(1392)	EUR(1392)	ALL(1392)	Serum alpha1-antitrypsin levels	HPOID:0006510	Chronic obstructive pulmonary disease	DOID:3083	chronic obstructive pulmonary disease	NA	NA	NA	NA	Chronic obstructive airway disease	NA	Research Support, N.I.H., Extramural	Research Support, Non-U.S. Gov't	Research Support, U.S. Gov't, Non-P.H.S.
13	24670163	rs1983870	C	T	rs1983870	23990791	3.04E-05	imputed, conditional on PI S and Z alleles in GWAS stage only	0.04	NA	1,392 European ancestry individuals	European(1392)	ALL(1392)	EUR(1392)	ALL(1392)	Serum alpha1-antitrypsin levels	HPOID:0006510	Chronic obstructive pulmonary disease	DOID:3083	chronic obstructive pulmonary disease	NA	NA	NA	NA	Chronic obstructive airway disease	NA	Research Support, N.I.H., Extramural	Research Support, Non-U.S. Gov't	Research Support, U.S. Gov't, Non-P.H.S.
13	24795489	rs715921	G	A	rs715921	22837378	8.00E-07	No asthma	1.2	NA	up to 3,368 European ancestry cases; up to 29,507 European ancestry controls	European(32875)	ALL(32875)	EUR(32875)	ALL(32875)	Airflow obstruction	HPOID:0006536	Obstructive lung disease	DOID:3083	chronic obstructive pulmonary disease	D000402	Airway Obstruction	EFOID:0003892	pulmonary function measurement	Chronic obstructive airway disease	rs715921-A	Research Support, N.I.H., Extramural	Meta-Analysis	Research Support, Non-U.S. Gov't
13	46363053	rs7988287	A	C	rs7988287	19300482	4.69E-05	NA	NA	NA	823 cases; 810 controls	NOPOP(1633)	ALL(1633)	NOPOP(1633)	ALL(1633)	Chronic obstructive pulmonary disease	HPOID:0006510	Chronic obstructive pulmonary disease	DOID:3083	chronic obstructive pulmonary disease	D029424	Pulmonary Disease, Chronic Obstructive	EFOID:0000341	chronic obstructive pulmonary disease	Chronic obstructive airway disease	NA	Research Support, N.I.H., Extramural	Research Support, U.S. Gov't, P.H.S.	Research Support, Non-U.S. Gov't
13	53494694	rs9536318	G	A	rs9536318	22837378	8.00E-07	No asthma	1.25	NA	up to 3,368 European ancestry cases; up to 29,507 European ancestry controls	European(32875)	ALL(32875)	EUR(32875)	ALL(32875)	Airflow obstruction	HPOID:0006536	Obstructive lung disease	DOID:3083	chronic obstructive pulmonary disease	D000402	Airway Obstruction	EFOID:0003892	pulmonary function measurement	Chronic obstructive airway disease	NA	Research Support, N.I.H., Extramural	Meta-Analysis	Research Support, Non-U.S. Gov't
13	68196361	rs4338667	G	T	rs4338667	23990791	2.71E-05	imputed, conditional on PI S and Z alleles in GWAS stage only	0.03	NA	1,392 European ancestry individuals	European(1392)	ALL(1392)	EUR(1392)	ALL(1392)	Serum alpha1-antitrypsin levels	HPOID:0006510	Chronic obstructive pulmonary disease	DOID:3083	chronic obstructive pulmonary disease	NA	NA	NA	NA	Chronic obstructive airway disease	NA	Research Support, N.I.H., Extramural	Research Support, Non-U.S. Gov't	Research Support, U.S. Gov't, Non-P.H.S.
13	69722212	rs9541789	T	G	rs9541789	23990791	1.63E-05	imputed, conditional on PI S and Z alleles in GWAS stage only	0.03	NA	1,392 European ancestry individuals	European(1392)	ALL(1392)	EUR(1392)	ALL(1392)	Serum alpha1-antitrypsin levels	HPOID:0006510	Chronic obstructive pulmonary disease	DOID:3083	chronic obstructive pulmonary disease	NA	NA	NA	NA	Chronic obstructive airway disease	NA	Research Support, N.I.H., Extramural	Research Support, Non-U.S. Gov't	Research Support, U.S. Gov't, Non-P.H.S.
13	69722321	rs9529519	C	T	rs9529519	23990791	1.68E-05	imputed, conditional on PI S and Z alleles in GWAS stage only	0.03	NA	1,392 European ancestry individuals	European(1392)	ALL(1392)	EUR(1392)	ALL(1392)	Serum alpha1-antitrypsin levels	HPOID:0006510	Chronic obstructive pulmonary disease	DOID:3083	chronic obstructive pulmonary disease	NA	NA	NA	NA	Chronic obstructive airway disease	NA	Research Support, N.I.H., Extramural	Research Support, Non-U.S. Gov't	Research Support, U.S. Gov't, Non-P.H.S.
13	69723025	rs9541790	A	G	rs9541790	23990791	2.90E-05	imputed, conditional on PI S and Z alleles in GWAS stage only	0.03	NA	1,392 European ancestry individuals	European(1392)	ALL(1392)	EUR(1392)	ALL(1392)	Serum alpha1-antitrypsin levels	HPOID:0006510	Chronic obstructive pulmonary disease	DOID:3083	chronic obstructive pulmonary disease	NA	NA	NA	NA	Chronic obstructive airway disease	NA	Research Support, N.I.H., Extramural	Research Support, Non-U.S. Gov't	Research Support, U.S. Gov't, Non-P.H.S.
13	69725358	rs9599423	T	C	rs9599423	23990791	1.31E-05	imputed, conditional on PI S and Z alleles in GWAS stage only	0.03	NA	1,392 European ancestry individuals	European(1392)	ALL(1392)	EUR(1392)	ALL(1392)	Serum alpha1-antitrypsin levels	HPOID:0006510	Chronic obstructive pulmonary disease	DOID:3083	chronic obstructive pulmonary disease	NA	NA	NA	NA	Chronic obstructive airway disease	NA	Research Support, N.I.H., Extramural	Research Support, Non-U.S. Gov't	Research Support, U.S. Gov't, Non-P.H.S.
13	69727042	rs1023818	A	G	rs1023818	23990791	8.04E-06	imputed, conditional on PI S and Z alleles in GWAS stage only	0.03	NA	1,392 European ancestry individuals	European(1392)	ALL(1392)	EUR(1392)	ALL(1392)	Serum alpha1-antitrypsin levels	HPOID:0006510	Chronic obstructive pulmonary disease	DOID:3083	chronic obstructive pulmonary disease	NA	NA	NA	NA	Chronic obstructive airway disease	NA	Research Support, N.I.H., Extramural	Research Support, Non-U.S. Gov't	Research Support, U.S. Gov't, Non-P.H.S.
13	69728322	rs1446379	C	A	rs1446379	23990791	7.61E-06	imputed, conditional on PI S and Z alleles in GWAS stage only	0.03	NA	1,392 European ancestry individuals	European(1392)	ALL(1392)	EUR(1392)	ALL(1392)	Serum alpha1-antitrypsin levels	HPOID:0006510	Chronic obstructive pulmonary disease	DOID:3083	chronic obstructive pulmonary disease	NA	NA	NA	NA	Chronic obstructive airway disease	NA	Research Support, N.I.H., Extramural	Research Support, Non-U.S. Gov't	Research Support, U.S. Gov't, Non-P.H.S.
13	69728606	rs1446378	G	A	rs1446378	23990791	7.45E-06	imputed, conditional on PI S and Z alleles in GWAS stage only	0.03	NA	1,392 European ancestry individuals	European(1392)	ALL(1392)	EUR(1392)	ALL(1392)	Serum alpha1-antitrypsin levels	HPOID:0006510	Chronic obstructive pulmonary disease	DOID:3083	chronic obstructive pulmonary disease	NA	NA	NA	NA	Chronic obstructive airway disease	NA	Research Support, N.I.H., Extramural	Research Support, Non-U.S. Gov't	Research Support, U.S. Gov't, Non-P.H.S.
13	69730587	rs9541793	C	A	rs9541793	23990791	7.37E-06	imputed, conditional on PI S and Z alleles in GWAS stage only	0.03	NA	1,392 European ancestry individuals	European(1392)	ALL(1392)	EUR(1392)	ALL(1392)	Serum alpha1-antitrypsin levels	HPOID:0006510	Chronic obstructive pulmonary disease	DOID:3083	chronic obstructive pulmonary disease	NA	NA	NA	NA	Chronic obstructive airway disease	NA	Research Support, N.I.H., Extramural	Research Support, Non-U.S. Gov't	Research Support, U.S. Gov't, Non-P.H.S.
13	69741249	rs9541803	G	A	rs9541803	23990791	2.46E-05	imputed, conditional on PI S and Z alleles in GWAS stage only	0.03	NA	1,392 European ancestry individuals	European(1392)	ALL(1392)	EUR(1392)	ALL(1392)	Serum alpha1-antitrypsin levels	HPOID:0006510	Chronic obstructive pulmonary disease	DOID:3083	chronic obstructive pulmonary disease	NA	NA	NA	NA	Chronic obstructive airway disease	NA	Research Support, N.I.H., Extramural	Research Support, Non-U.S. Gov't	Research Support, U.S. Gov't, Non-P.H.S.
13	77096697	rs4885410	T	C	rs4885410	22837378	3.32E-11	NA	NA	NA	up to 3,368 European ancestry cases; up to 29,507 European ancestry controls	European(32875)	ALL(32875)	EUR(32875)	ALL(32875)	Airflow obstruction	HPOID:0006536	Obstructive lung disease	DOID:3083	chronic obstructive pulmonary disease	D000402	Airway Obstruction	EFOID:0003892	pulmonary function measurement	Chronic obstructive airway disease	NA	Research Support, N.I.H., Extramural	Meta-Analysis	Research Support, Non-U.S. Gov't
13	105421263	rs7331728	A	G	rs7331728	22986903	0.0000036	NA	NA	NA	4,048 European ancestry cases	European(4048)	ALL(4048)	EUR(4048)	ALL(4048)	Chronic obstructive pulmonary disease (moderate to severe)	HPOID:0006510	Chronic obstructive pulmonary disease	DOID:3083	chronic obstructive pulmonary disease	NA	NA	NA	NA	Chronic obstructive airway disease	NA	Multicenter Study	Research Support, N.I.H., Extramural	Research Support, Non-U.S. Gov't
13	113447211	rs447590	A	C	rs447590	23990791	3.75E-05	imputed, conditional on PI S and Z alleles in GWAS stage only	0.03	NA	1,392 European ancestry individuals	European(1392)	ALL(1392)	EUR(1392)	ALL(1392)	Serum alpha1-antitrypsin levels	HPOID:0006510	Chronic obstructive pulmonary disease	DOID:3083	chronic obstructive pulmonary disease	NA	NA	NA	NA	Chronic obstructive airway disease	NA	Research Support, N.I.H., Extramural	Research Support, Non-U.S. Gov't	Research Support, U.S. Gov't, Non-P.H.S.
14	28728111	rs6576132	C	A	rs6576132	24825563	5.00E-08	(AA)	0	[0.003-0.005] unit increase	820 African American cases	African American(820)	ALL(820)	AFR(820)	ALL(820)	Resting oxygen saturation in chronic obstructive pulmonary disease (pulse oxymetry)	HPOID:0006510	Chronic obstructive pulmonary disease	DOID:3083	chronic obstructive pulmonary disease	NA	NA	NA	NA	Chronic obstructive airway disease	rs6576132-A	Clinical Trial	Research Support, N.I.H., Extramural	Research Support, Non-U.S. Gov't
14	32342702	rs8009673	C	A	rs8009673	19300482	9.54E-05	NA	NA	NA	823 cases; 810 controls	NOPOP(1633)	ALL(1633)	NOPOP(1633)	ALL(1633)	Chronic obstructive pulmonary disease	HPOID:0006510	Chronic obstructive pulmonary disease	DOID:3083	chronic obstructive pulmonary disease	D029424	Pulmonary Disease, Chronic Obstructive	EFOID:0000341	chronic obstructive pulmonary disease	Chronic obstructive airway disease	NA	Research Support, N.I.H., Extramural	Research Support, U.S. Gov't, P.H.S.	Research Support, Non-U.S. Gov't
14	38085277	rs12147245	T	A	rs12147245	22986903	0.000000021	NA	NA	NA	4,048 European ancestry cases	European(4048)	ALL(4048)	EUR(4048)	ALL(4048)	Chronic obstructive pulmonary disease (moderate to severe)	HPOID:0006510	Chronic obstructive pulmonary disease	DOID:3083	chronic obstructive pulmonary disease	NA	NA	NA	NA	Chronic obstructive airway disease	NA	Multicenter Study	Research Support, N.I.H., Extramural	Research Support, Non-U.S. Gov't
14	38111870	rs177852	C	T	rs177852	22986903	0.000000063	NA	NA	NA	4,048 European ancestry cases	European(4048)	ALL(4048)	EUR(4048)	ALL(4048)	Chronic obstructive pulmonary disease (moderate to severe)	HPOID:0006510	Chronic obstructive pulmonary disease	DOID:3083	chronic obstructive pulmonary disease	NA	NA	NA	NA	Chronic obstructive airway disease	NA	Multicenter Study	Research Support, N.I.H., Extramural	Research Support, Non-U.S. Gov't
14	38116311	rs177858	T	G	rs177858	22986903	0.00000099	NA	NA	NA	4,048 European ancestry cases	European(4048)	ALL(4048)	EUR(4048)	ALL(4048)	Chronic obstructive pulmonary disease (moderate to severe)	HPOID:0006510	Chronic obstructive pulmonary disease	DOID:3083	chronic obstructive pulmonary disease	NA	NA	NA	NA	Chronic obstructive airway disease	NA	Multicenter Study	Research Support, N.I.H., Extramural	Research Support, Non-U.S. Gov't
14	38116960	rs177859	G	A	rs177859	22986903	0.00000099	NA	NA	NA	4,048 European ancestry cases	European(4048)	ALL(4048)	EUR(4048)	ALL(4048)	Chronic obstructive pulmonary disease (moderate to severe)	HPOID:0006510	Chronic obstructive pulmonary disease	DOID:3083	chronic obstructive pulmonary disease	NA	NA	NA	NA	Chronic obstructive airway disease	NA	Multicenter Study	Research Support, N.I.H., Extramural	Research Support, Non-U.S. Gov't
14	39722023	rs10134365	G	C	rs10134365	19300482	2.50E-05	NA	NA	NA	823 cases; 810 controls	NOPOP(1633)	ALL(1633)	NOPOP(1633)	ALL(1633)	Chronic obstructive pulmonary disease	HPOID:0006510	Chronic obstructive pulmonary disease	DOID:3083	chronic obstructive pulmonary disease	D029424	Pulmonary Disease, Chronic Obstructive	EFOID:0000341	chronic obstructive pulmonary disease	Chronic obstructive airway disease	NA	Research Support, N.I.H., Extramural	Research Support, U.S. Gov't, P.H.S.	Research Support, Non-U.S. Gov't
14	48555664	rs9788469	A	G	rs9788469	19300482	1.43E-05	NA	NA	NA	823 cases; 810 controls	NOPOP(1633)	ALL(1633)	NOPOP(1633)	ALL(1633)	Chronic obstructive pulmonary disease	HPOID:0006510	Chronic obstructive pulmonary disease	DOID:3083	chronic obstructive pulmonary disease	D029424	Pulmonary Disease, Chronic Obstructive	EFOID:0000341	chronic obstructive pulmonary disease	Chronic obstructive airway disease	NA	Research Support, N.I.H., Extramural	Research Support, U.S. Gov't, P.H.S.	Research Support, Non-U.S. Gov't
14	56886686	rs17832777	A	C	rs17832777	23144326	6.00E-06	TNFA	NA	NA	Up to 1,951 European ancestry smokers	European(1951)	ALL(1951)	EUR(1951)	ALL(1951)	Chronic obstructive pulmonary disease-related biomarkers	HPOID:0006510	Chronic obstructive pulmonary disease	DOID:3083	chronic obstructive pulmonary disease	D029424	Pulmonary Disease, Chronic Obstructive	EFOID:0005080	surfactant protein D measurement	Chronic obstructive airway disease	rs17832777-C	Clinical Trial	Research Support, N.I.H., Extramural	Research Support, Non-U.S. Gov't
14	61852793	rs1886467	A	G	rs1886467	22837378	1.86E-08	NA	NA	NA	up to 3,368 European ancestry cases; up to 29,507 European ancestry controls	European(32875)	ALL(32875)	EUR(32875)	ALL(32875)	Airflow obstruction	HPOID:0006536	Obstructive lung disease	DOID:3083	chronic obstructive pulmonary disease	D000402	Airway Obstruction	EFOID:0003892	pulmonary function measurement	Chronic obstructive airway disease	NA	Research Support, N.I.H., Extramural	Meta-Analysis	Research Support, Non-U.S. Gov't
14	62401183	rs17099345	G	A	rs17099345	19300482	6.93E-05	NA	NA	NA	823 cases; 810 controls	NOPOP(1633)	ALL(1633)	NOPOP(1633)	ALL(1633)	Chronic obstructive pulmonary disease	HPOID:0006510	Chronic obstructive pulmonary disease	DOID:3083	chronic obstructive pulmonary disease	D029424	Pulmonary Disease, Chronic Obstructive	EFOID:0000341	chronic obstructive pulmonary disease	Chronic obstructive airway disease	NA	Research Support, N.I.H., Extramural	Research Support, U.S. Gov't, P.H.S.	Research Support, Non-U.S. Gov't
14	65865625	rs7147624	T	G	rs7147624	23144326	5.00E-06	TNFA	NA	NA	Up to 1,951 European ancestry smokers	European(1951)	ALL(1951)	EUR(1951)	ALL(1951)	Chronic obstructive pulmonary disease-related biomarkers	HPOID:0006510	Chronic obstructive pulmonary disease	DOID:3083	chronic obstructive pulmonary disease	D029424	Pulmonary Disease, Chronic Obstructive	EFOID:0005080	surfactant protein D measurement	Chronic obstructive airway disease	rs7147624-T	Clinical Trial	Research Support, N.I.H., Extramural	Research Support, Non-U.S. Gov't
14	71652891	rs6574008	C	G	rs6574008	23990791	4.51E-05	imputed, conditional on PI S and Z alleles in GWAS stage only	0.03	NA	1,392 European ancestry individuals	European(1392)	ALL(1392)	EUR(1392)	ALL(1392)	Serum alpha1-antitrypsin levels	HPOID:0006510	Chronic obstructive pulmonary disease	DOID:3083	chronic obstructive pulmonary disease	NA	NA	NA	NA	Chronic obstructive airway disease	NA	Research Support, N.I.H., Extramural	Research Support, Non-U.S. Gov't	Research Support, U.S. Gov't, Non-P.H.S.
14	71653170	rs10145569	T	A	rs10145569	23990791	4.03E-05	imputed, conditional on PI S and Z alleles in GWAS stage only	0.03	NA	1,392 European ancestry individuals	European(1392)	ALL(1392)	EUR(1392)	ALL(1392)	Serum alpha1-antitrypsin levels	HPOID:0006510	Chronic obstructive pulmonary disease	DOID:3083	chronic obstructive pulmonary disease	NA	NA	NA	NA	Chronic obstructive airway disease	NA	Research Support, N.I.H., Extramural	Research Support, Non-U.S. Gov't	Research Support, U.S. Gov't, Non-P.H.S.
14	81877382	rs8022070	C	T	rs8022070	19300482	8.10E-05	NA	NA	NA	823 cases; 810 controls	NOPOP(1633)	ALL(1633)	NOPOP(1633)	ALL(1633)	Chronic obstructive pulmonary disease	HPOID:0006510	Chronic obstructive pulmonary disease	DOID:3083	chronic obstructive pulmonary disease	D029424	Pulmonary Disease, Chronic Obstructive	EFOID:0000341	chronic obstructive pulmonary disease	Chronic obstructive airway disease	NA	Research Support, N.I.H., Extramural	Research Support, U.S. Gov't, P.H.S.	Research Support, Non-U.S. Gov't
14	93115410	rs754388	G	C	rs754388	24621683	5.00E-09	NA	NA	NA	5,812 European ancestry cases; 3,955 European ancestry controls; 821 African American cases; 1,749 African American controls	African American(2570)	European(9767)	ALL(12337)	AFR(2570)	EUR(9767)	ALL(12337)	Chronic obstructive pulmonary disease (moderate to severe)	HPOID:0006510	Chronic obstructive pulmonary disease	DOID:3083	chronic obstructive pulmonary disease	NA	NA	NA	NA	Chronic obstructive airway disease	rs754388-C	Research Support, N.I.H., Extramural
14	93115410	rs754388	G	C	rs754388	24621683	7.00E-08	NA	NA	NA	3,145 European ancestry cases; 3,955 European ancestry controls; 352 African American cases; 1,749 African American controls	African American(2101)	European(7100)	ALL(9201)	AFR(2101)	EUR(7100)	ALL(9201)	Chronic obstructive pulmonary disease (severe)	HPOID:0006510	Chronic obstructive pulmonary disease	DOID:3083	chronic obstructive pulmonary disease	NA	NA	NA	NA	Chronic obstructive airway disease	rs754388-C	Research Support, N.I.H., Extramural
14	97529421	rs1622472	T	C	rs1622472	19300482	6.71E-05	NA	NA	NA	823 cases; 810 controls	NOPOP(1633)	ALL(1633)	NOPOP(1633)	ALL(1633)	Chronic obstructive pulmonary disease	HPOID:0006510	Chronic obstructive pulmonary disease	DOID:3083	chronic obstructive pulmonary disease	D029424	Pulmonary Disease, Chronic Obstructive	EFOID:0000341	chronic obstructive pulmonary disease	Chronic obstructive airway disease	NA	Research Support, N.I.H., Extramural	Research Support, U.S. Gov't, P.H.S.	Research Support, Non-U.S. Gov't
14	97535923	rs1738899	G	A	rs1738899	19300482	6.09E-05	NA	NA	NA	823 cases; 810 controls	NOPOP(1633)	ALL(1633)	NOPOP(1633)	ALL(1633)	Chronic obstructive pulmonary disease	HPOID:0006510	Chronic obstructive pulmonary disease	DOID:3083	chronic obstructive pulmonary disease	D029424	Pulmonary Disease, Chronic Obstructive	EFOID:0000341	chronic obstructive pulmonary disease	Chronic obstructive airway disease	NA	Research Support, N.I.H., Extramural	Research Support, U.S. Gov't, P.H.S.	Research Support, Non-U.S. Gov't
14	99402433	rs200303	G	T	rs200303	19300482	7.96E-05	NA	NA	NA	823 cases; 810 controls	NOPOP(1633)	ALL(1633)	NOPOP(1633)	ALL(1633)	Chronic obstructive pulmonary disease	HPOID:0006510	Chronic obstructive pulmonary disease	DOID:3083	chronic obstructive pulmonary disease	D029424	Pulmonary Disease, Chronic Obstructive	EFOID:0000341	chronic obstructive pulmonary disease	Chronic obstructive airway disease	NA	Research Support, N.I.H., Extramural	Research Support, U.S. Gov't, P.H.S.	Research Support, Non-U.S. Gov't
15	49704741	rs12591300	G	A	rs12591300	21921092	7.90E-07	Chronic obstructive pulmonary disease (COPD)	NA	NA	58 Costa Rica descent cases; 57 Costa Rica descent controls	Costa Rica(115)	ALL(115)	HIS(115)	ALL(115)	chronic obstructive pulmonary disease	HPOID:0006510	Chronic obstructive pulmonary disease	DOID:3083	chronic obstructive pulmonary disease	D029424	Pulmonary Disease, Chronic Obstructive	EFOID:0000341	chronic obstructive pulmonary disease	Chronic obstructive airway disease	NA	Research Support, N.I.H., Extramural	Research Support, Non-U.S. Gov't	T
15	49755842	rs4480740	G	A	rs4480740	21921092	1.03E-06	Chronic obstructive pulmonary disease (COPD)	NA	NA	58 Costa Rica descent cases; 57 Costa Rica descent controls	Costa Rica(115)	ALL(115)	HIS(115)	ALL(115)	chronic obstructive pulmonary disease	HPOID:0006510	Chronic obstructive pulmonary disease	DOID:3083	chronic obstructive pulmonary disease	D029424	Pulmonary Disease, Chronic Obstructive	EFOID:0000341	chronic obstructive pulmonary disease	Chronic obstructive airway disease	NA	Research Support, N.I.H., Extramural	Research Support, Non-U.S. Gov't	A
15	50004083	rs17404727	T	C	rs17404727	21921092	7.17E-07	Chronic obstructive pulmonary disease (COPD)	NA	NA	58 Costa Rica descent cases; 57 Costa Rica descent controls	Costa Rica(115)	ALL(115)	HIS(115)	ALL(115)	chronic obstructive pulmonary disease	HPOID:0006510	Chronic obstructive pulmonary disease	DOID:3083	chronic obstructive pulmonary disease	D029424	Pulmonary Disease, Chronic Obstructive	EFOID:0000341	chronic obstructive pulmonary disease	Chronic obstructive airway disease	NA	Research Support, N.I.H., Extramural	Research Support, Non-U.S. Gov't	T
15	63099535	rs4774453	G	A	rs4774453	22837378	2.95E-09	NA	NA	NA	up to 3,368 European ancestry cases; up to 29,507 European ancestry controls	European(32875)	ALL(32875)	EUR(32875)	ALL(32875)	Airflow obstruction	HPOID:0006536	Obstructive lung disease	DOID:3083	chronic obstructive pulmonary disease	D000402	Airway Obstruction	EFOID:0003892	pulmonary function measurement	Chronic obstructive airway disease	NA	Research Support, N.I.H., Extramural	Meta-Analysis	Research Support, Non-U.S. Gov't
15	71679959	rs2044029	A	G	rs2044029	22837378	1.00E-07	All	1.17	NA	up to 3,368 European ancestry cases; up to 29,507 European ancestry controls	European(32875)	ALL(32875)	EUR(32875)	ALL(32875)	Airflow obstruction	HPOID:0006536	Obstructive lung disease	DOID:3083	chronic obstructive pulmonary disease	D000402	Airway Obstruction	EFOID:0003892	pulmonary function measurement	Chronic obstructive airway disease	rs2044029-A	Research Support, N.I.H., Extramural	Meta-Analysis	Research Support, Non-U.S. Gov't
15	74716609	rs8036030	A	G	rs8036030	22837378	8.00E-06	No asthma	1.18	NA	up to 3,368 European ancestry cases; up to 29,507 European ancestry controls	European(32875)	ALL(32875)	EUR(32875)	ALL(32875)	Airflow obstruction	HPOID:0006536	Obstructive lung disease	DOID:3083	chronic obstructive pulmonary disease	D000402	Airway Obstruction	EFOID:0003892	pulmonary function measurement	Chronic obstructive airway disease	NA	Research Support, N.I.H., Extramural	Meta-Analysis	Research Support, Non-U.S. Gov't
15	78745707	rs2656069	C	T	rs2656069	21921092	1.35E-06	Chronic obstructive pulmonary disease (COPD)	NA	NA	58 Costa Rica descent cases; 57 Costa Rica descent controls	Costa Rica(115)	ALL(115)	HIS(115)	ALL(115)	chronic obstructive pulmonary disease	HPOID:0006510	Chronic obstructive pulmonary disease	DOID:3083	chronic obstructive pulmonary disease	D029424	Pulmonary Disease, Chronic Obstructive	EFOID:0000341	chronic obstructive pulmonary disease	Chronic obstructive airway disease	NA	Research Support, N.I.H., Extramural	Research Support, Non-U.S. Gov't	A
15	78783277	rs11858836	G	A	rs11858836	22080838	1.00E-06	NA	1.29	[1.13-1.47]	3,499 European ancestry cases; 1,922 European ancestry controls	European(5421)	ALL(5421)	EUR(5421)	ALL(5421)	Chronic obstructive pulmonary disease	HPOID:0006510	Chronic obstructive pulmonary disease	DOID:3083	chronic obstructive pulmonary disease	D029424	Pulmonary Disease, Chronic Obstructive	EFOID:0000341	chronic obstructive pulmonary disease	Chronic obstructive airway disease	NA	Research Support, N.I.H., Extramural	Research Support, U.S. Gov't, P.H.S.	Meta-Analysis
15	78789488	rs13180	C	T	rs13180	20173748	2.00E-08	NA	1.3	[1.18-1.43]	2,940 white cases; 1,380 white controls	NOPOP(4320)	ALL(4320)	NOPOP(4320)	ALL(4320)	Chronic obstructive pulmonary disease	HPOID:0006510	Chronic obstructive pulmonary disease	DOID:3083	chronic obstructive pulmonary disease	D029424	Pulmonary Disease, Chronic Obstructive	EFOID:0000341	chronic obstructive pulmonary disease	Chronic obstructive airway disease	NA	Research Support, N.I.H., Extramural	Research Support, Non-U.S. Gov't	Research Support, U.S. Gov't, Non-P.H.S.
15	78789488	rs13180	C	T	rs13180	21921092	9.93E-08	Chronic obstructive pulmonary disease (COPD)	NA	NA	58 Costa Rica descent cases; 57 Costa Rica descent controls	Costa Rica(115)	ALL(115)	HIS(115)	ALL(115)	chronic obstructive pulmonary disease	HPOID:0006510	Chronic obstructive pulmonary disease	DOID:3083	chronic obstructive pulmonary disease	D029424	Pulmonary Disease, Chronic Obstructive	EFOID:0000341	chronic obstructive pulmonary disease	Chronic obstructive airway disease	NA	Research Support, N.I.H., Extramural	Research Support, Non-U.S. Gov't	C
15	78792527	rs1062980	T	C	rs1062980	20173748	3.42E-05	NA	NA	NA	2,940 white cases; 1,380 white controls	NOPOP(4320)	ALL(4320)	NOPOP(4320)	ALL(4320)	Chronic obstructive pulmonary disease	HPOID:0006510	Chronic obstructive pulmonary disease	DOID:3083	chronic obstructive pulmonary disease	D029424	Pulmonary Disease, Chronic Obstructive	EFOID:0000341	chronic obstructive pulmonary disease	Chronic obstructive airway disease	NA	Research Support, N.I.H., Extramural	Research Support, Non-U.S. Gov't	Research Support, U.S. Gov't, Non-P.H.S.
15	78792527	rs1062980	T	C	rs1062980	21921092	9.53E-08	Chronic obstructive pulmonary disease (COPD)	NA	NA	58 Costa Rica descent cases; 57 Costa Rica descent controls	Costa Rica(115)	ALL(115)	HIS(115)	ALL(115)	chronic obstructive pulmonary disease	HPOID:0006510	Chronic obstructive pulmonary disease	DOID:3083	chronic obstructive pulmonary disease	D029424	Pulmonary Disease, Chronic Obstructive	EFOID:0000341	chronic obstructive pulmonary disease	Chronic obstructive airway disease	NA	Research Support, N.I.H., Extramural	Research Support, Non-U.S. Gov't	T
15	78806023	rs8034191	T	C	rs8034191	19300482	1.00E-10	NA	1.4	[1.18-1.67]	823 cases; 810 controls	NOPOP(1633)	ALL(1633)	NOPOP(1633)	ALL(1633)	Chronic obstructive pulmonary disease	HPOID:0006510	Chronic obstructive pulmonary disease	DOID:3083	chronic obstructive pulmonary disease	D029424	Pulmonary Disease, Chronic Obstructive	EFOID:0000341	chronic obstructive pulmonary disease	Chronic obstructive airway disease	rs8034191-C	Research Support, N.I.H., Extramural	Research Support, U.S. Gov't, P.H.S.	Research Support, Non-U.S. Gov't
15	78806023	rs8034191	T	C	rs8034191	20173748	5.31E-06	NA	NA	NA	2,940 white cases; 1,380 white controls	NOPOP(4320)	ALL(4320)	NOPOP(4320)	ALL(4320)	Chronic obstructive pulmonary disease	HPOID:0006510	Chronic obstructive pulmonary disease	DOID:3083	chronic obstructive pulmonary disease	D029424	Pulmonary Disease, Chronic Obstructive	EFOID:0000341	chronic obstructive pulmonary disease	Chronic obstructive airway disease	NA	Research Support, N.I.H., Extramural	Research Support, Non-U.S. Gov't	Research Support, U.S. Gov't, Non-P.H.S.
15	78806023	rs8034191	T	C	rs8034191	21921092	1.06E-07	Chronic obstructive pulmonary disease (COPD)	NA	NA	58 Costa Rica descent cases; 57 Costa Rica descent controls	Costa Rica(115)	ALL(115)	HIS(115)	ALL(115)	chronic obstructive pulmonary disease	HPOID:0006510	Chronic obstructive pulmonary disease	DOID:3083	chronic obstructive pulmonary disease	D029424	Pulmonary Disease, Chronic Obstructive	EFOID:0000341	chronic obstructive pulmonary disease	Chronic obstructive airway disease	NA	Research Support, N.I.H., Extramural	Research Support, Non-U.S. Gov't	T
15	78816057	rs8031948	G	T	rs8031948	22837378	3.00E-09	Smokers	1.22	NA	up to 3,368 European ancestry cases; up to 29,507 European ancestry controls	European(32875)	ALL(32875)	EUR(32875)	ALL(32875)	Airflow obstruction	HPOID:0006536	Obstructive lung disease	DOID:3083	chronic obstructive pulmonary disease	D000402	Airway Obstruction	EFOID:0003892	pulmonary function measurement	Chronic obstructive airway disease	rs8031948-T	Research Support, N.I.H., Extramural	Meta-Analysis	Research Support, Non-U.S. Gov't
15	78826948	rs2036534	T	C	rs2036534	21921092	1.38E-06	Chronic obstructive pulmonary disease (COPD)	NA	NA	58 Costa Rica descent cases; 57 Costa Rica descent controls	Costa Rica(115)	ALL(115)	HIS(115)	ALL(115)	chronic obstructive pulmonary disease	HPOID:0006510	Chronic obstructive pulmonary disease	DOID:3083	chronic obstructive pulmonary disease	D029424	Pulmonary Disease, Chronic Obstructive	EFOID:0000341	chronic obstructive pulmonary disease	Chronic obstructive airway disease	NA	Research Support, N.I.H., Extramural	Research Support, Non-U.S. Gov't	T
15	78827631	rs28675338	C	T	rs28675338	21685187	1.00E-07	Lifetime average CPD	5.21	NA	3,441 Caucasian ever-smokers with COPD	Caucasian(3441)	ALL(3441)	EUR(3441)	ALL(3441)	Chronic obstructive pulmonary disease	HPOID:0006510	Chronic obstructive pulmonary disease	DOID:3083	chronic obstructive pulmonary disease	D029424	Pulmonary Disease, Chronic Obstructive	EFOID:0000341	chronic obstructive pulmonary disease	Chronic obstructive airway disease	rs28675338-T	Randomized Controlled Trial	Multicenter Study	Research Support, N.I.H., Extramural
15	78827631	rs58709975	C	CT	rs28675338	21685187	1.00E-07	Lifetime average CPD	5.21	NA	3,441 Caucasian ever-smokers with COPD	Caucasian(3441)	ALL(3441)	EUR(3441)	ALL(3441)	Chronic obstructive pulmonary disease	HPOID:0006510	Chronic obstructive pulmonary disease	DOID:3083	chronic obstructive pulmonary disease	D029424	Pulmonary Disease, Chronic Obstructive	EFOID:0000341	chronic obstructive pulmonary disease	Chronic obstructive airway disease	rs28675338-T	Randomized Controlled Trial	Multicenter Study	Research Support, N.I.H., Extramural
15	78867482	rs17486278	A	C	rs17486278	22837378	2.00E-07	All	1.18	NA	up to 3,368 European ancestry cases; up to 29,507 European ancestry controls	European(32875)	ALL(32875)	EUR(32875)	ALL(32875)	Airflow obstruction	HPOID:0006536	Obstructive lung disease	DOID:3083	chronic obstructive pulmonary disease	D000402	Airway Obstruction	EFOID:0003892	pulmonary function measurement	Chronic obstructive airway disease	NA	Research Support, N.I.H., Extramural	Meta-Analysis	Research Support, Non-U.S. Gov't
15	78894339	rs1051730	G	A	rs1051730	20173748	2.14E-05	NA	NA	NA	2,940 white cases; 1,380 white controls	NOPOP(4320)	ALL(4320)	NOPOP(4320)	ALL(4320)	Chronic obstructive pulmonary disease	HPOID:0006510	Chronic obstructive pulmonary disease	DOID:3083	chronic obstructive pulmonary disease	D029424	Pulmonary Disease, Chronic Obstructive	EFOID:0000341	chronic obstructive pulmonary disease	Chronic obstructive airway disease	NA	Research Support, N.I.H., Extramural	Research Support, Non-U.S. Gov't	Research Support, U.S. Gov't, Non-P.H.S.
15	78894339	rs1051730	G	A	rs1051730	21921092	5.54E-07	Chronic obstructive pulmonary disease (COPD)	NA	NA	58 Costa Rica descent cases; 57 Costa Rica descent controls	Costa Rica(115)	ALL(115)	HIS(115)	ALL(115)	chronic obstructive pulmonary disease	HPOID:0006510	Chronic obstructive pulmonary disease	DOID:3083	chronic obstructive pulmonary disease	D029424	Pulmonary Disease, Chronic Obstructive	EFOID:0000341	chronic obstructive pulmonary disease	Chronic obstructive airway disease	NA	Research Support, N.I.H., Extramural	Research Support, Non-U.S. Gov't	C
15	78898723	rs12914385	C	T	rs12914385	21921092	2.81E-07	Chronic obstructive pulmonary disease (COPD)	NA	NA	58 Costa Rica descent cases; 57 Costa Rica descent controls	Costa Rica(115)	ALL(115)	HIS(115)	ALL(115)	chronic obstructive pulmonary disease	HPOID:0006510	Chronic obstructive pulmonary disease	DOID:3083	chronic obstructive pulmonary disease	D029424	Pulmonary Disease, Chronic Obstructive	EFOID:0000341	chronic obstructive pulmonary disease	Chronic obstructive airway disease	NA	Research Support, N.I.H., Extramural	Research Support, Non-U.S. Gov't	C
15	78898723	rs12914385	C	T	rs12914385	24621683	3.00E-16	NA	1.39	[1.29-1.51]	3,145 European ancestry cases; 3,955 European ancestry controls; 352 African American cases; 1,749 African American controls	African American(2101)	European(7100)	ALL(9201)	AFR(2101)	EUR(7100)	ALL(9201)	Chronic obstructive pulmonary disease (severe)	HPOID:0006510	Chronic obstructive pulmonary disease	DOID:3083	chronic obstructive pulmonary disease	NA	NA	NA	NA	Chronic obstructive airway disease	rs12914385-T	Research Support, N.I.H., Extramural
15	78898723	rs12914385	C	T	rs12914385	24621683	6.00E-14	NA	1.28	[1.20-1.36]	5,812 European ancestry cases; 3,955 European ancestry controls; 821 African American cases; 1,749 African American controls	African American(2570)	European(9767)	ALL(12337)	AFR(2570)	EUR(9767)	ALL(12337)	Chronic obstructive pulmonary disease (moderate to severe)	HPOID:0006510	Chronic obstructive pulmonary disease	DOID:3083	chronic obstructive pulmonary disease	NA	NA	NA	NA	Chronic obstructive airway disease	rs12914385-T	Research Support, N.I.H., Extramural
15	86233351	rs16943236	C	T	rs16943236	19300482	7.68E-05	NA	NA	NA	823 cases; 810 controls	NOPOP(1633)	ALL(1633)	NOPOP(1633)	ALL(1633)	Chronic obstructive pulmonary disease	HPOID:0006510	Chronic obstructive pulmonary disease	DOID:3083	chronic obstructive pulmonary disease	D029424	Pulmonary Disease, Chronic Obstructive	EFOID:0000341	chronic obstructive pulmonary disease	Chronic obstructive airway disease	NA	Research Support, N.I.H., Extramural	Research Support, U.S. Gov't, P.H.S.	Research Support, Non-U.S. Gov't
15	90089276	rs8038108	C	A	rs8038108	24825563	5.00E-09	(AA)	0.01	[0.006-0.013] unit decrease	820 African American cases	African American(820)	ALL(820)	AFR(820)	ALL(820)	Resting oxygen saturation in chronic obstructive pulmonary disease (pulse oxymetry)	HPOID:0006510	Chronic obstructive pulmonary disease	DOID:3083	chronic obstructive pulmonary disease	NA	NA	NA	NA	Chronic obstructive airway disease	rs8038108-C	Clinical Trial	Research Support, N.I.H., Extramural	Research Support, Non-U.S. Gov't
15	92883840	rs12905014	T	C	rs12905014	22837378	4.00E-07	FEV1 65%	1.75	NA	up to 3,368 European ancestry cases; up to 29,507 European ancestry controls	European(32875)	ALL(32875)	EUR(32875)	ALL(32875)	Airflow obstruction	HPOID:0006536	Obstructive lung disease	DOID:3083	chronic obstructive pulmonary disease	D000402	Airway Obstruction	EFOID:0003892	pulmonary function measurement	Chronic obstructive airway disease	NA	Research Support, N.I.H., Extramural	Meta-Analysis	Research Support, Non-U.S. Gov't
15	98048196	rs2399702	C	T	rs2399702	23990791	3.95E-05	imputed, conditional on PI S and Z alleles in GWAS stage only	0.06	NA	1,392 European ancestry individuals	European(1392)	ALL(1392)	EUR(1392)	ALL(1392)	Serum alpha1-antitrypsin levels	HPOID:0006510	Chronic obstructive pulmonary disease	DOID:3083	chronic obstructive pulmonary disease	NA	NA	NA	NA	Chronic obstructive airway disease	NA	Research Support, N.I.H., Extramural	Research Support, Non-U.S. Gov't	Research Support, U.S. Gov't, Non-P.H.S.
16	16114892	rs246214	C	T	rs246214	22837378	6.80E-11	NA	NA	NA	up to 3,368 European ancestry cases; up to 29,507 European ancestry controls	European(32875)	ALL(32875)	EUR(32875)	ALL(32875)	Airflow obstruction	HPOID:0006536	Obstructive lung disease	DOID:3083	chronic obstructive pulmonary disease	D000402	Airway Obstruction	EFOID:0003892	pulmonary function measurement	Chronic obstructive airway disease	NA	Research Support, N.I.H., Extramural	Meta-Analysis	Research Support, Non-U.S. Gov't
16	23352848	rs239349	G	A	rs239349	19300482	3.09E-05	NA	NA	NA	823 cases; 810 controls	NOPOP(1633)	ALL(1633)	NOPOP(1633)	ALL(1633)	Chronic obstructive pulmonary disease	HPOID:0006510	Chronic obstructive pulmonary disease	DOID:3083	chronic obstructive pulmonary disease	D029424	Pulmonary Disease, Chronic Obstructive	EFOID:0000341	chronic obstructive pulmonary disease	Chronic obstructive airway disease	NA	Research Support, N.I.H., Extramural	Research Support, U.S. Gov't, P.H.S.	Research Support, Non-U.S. Gov't
16	27977483	rs2898879	C	T	rs2898879	19300482	1.35E-05	NA	NA	NA	823 cases; 810 controls	NOPOP(1633)	ALL(1633)	NOPOP(1633)	ALL(1633)	Chronic obstructive pulmonary disease	HPOID:0006510	Chronic obstructive pulmonary disease	DOID:3083	chronic obstructive pulmonary disease	D029424	Pulmonary Disease, Chronic Obstructive	EFOID:0000341	chronic obstructive pulmonary disease	Chronic obstructive airway disease	NA	Research Support, N.I.H., Extramural	Research Support, U.S. Gov't, P.H.S.	Research Support, Non-U.S. Gov't
16	53816275	rs8050136	C	A	rs8050136	21037115	4.00E-08	BMI	NA	NA	2,272 Caucasian individuals; 933 Norwegian individuals	Caucasian(2272)	Norwegian(933)	ALL(3205)	EUR(3205)	ALL(3205)	Body mass in chronic obstructive pulmonary disease	HPOID:0001507	HPOID:0006510	Growth abnormality	Chronic obstructive pulmonary disease	DOID:3083	chronic obstructive pulmonary disease	D029424	Pulmonary Disease, Chronic Obstructive	EFOID:0004340	chronic obstructive pulmonary disease	Chronic obstructive airway disease	rs8050136-A
16	70913984	rs12149070	C	T	rs12149070	23144326	8.00E-06	IL8	NA	NA	Up to 1,951 European ancestry smokers	European(1951)	ALL(1951)	EUR(1951)	ALL(1951)	Chronic obstructive pulmonary disease-related biomarkers	HPOID:0006510	Chronic obstructive pulmonary disease	DOID:3083	chronic obstructive pulmonary disease	D029424	Pulmonary Disease, Chronic Obstructive	EFOID:0005080	surfactant protein D measurement	Chronic obstructive airway disease	rs12149070-T	Clinical Trial	Research Support, N.I.H., Extramural	Research Support, Non-U.S. Gov't
16	84423034	rs8048576	G	A	rs8048576	23144326	9.00E-13	SP-D	NA	NA	Up to 1,951 European ancestry smokers	European(1951)	ALL(1951)	EUR(1951)	ALL(1951)	Chronic obstructive pulmonary disease-related biomarkers	HPOID:0006510	Chronic obstructive pulmonary disease	DOID:3083	chronic obstructive pulmonary disease	D029424	Pulmonary Disease, Chronic Obstructive	EFOID:0005080	surfactant protein D measurement	Chronic obstructive airway disease	rs8048576-A	Clinical Trial	Research Support, N.I.H., Extramural	Research Support, Non-U.S. Gov't
17	74988444	rs7221059	C	A	rs7221059	24383474	3.00E-08	(Chinese)	0.33	[0.21-0.44] unit decrease	2,587 European ancestry individuals; 2,510 African American individuals; 2,113 Hispanic individuals; 704 Chinese ancestry individuals	Chinese(704)	African American(2510)	European(2587)	Hispanic(2113)	ALL(7914)	ASN(704)	HIS(2113)	AFR(2510)	EUR(2587)	ALL(7914)	Pulmonary emphysema	HPOID:0006510	Chronic obstructive pulmonary disease	DOID:9675	pulmonary emphysema	NA	NA	NA
17	75400100	rs892961	T	A	rs892961	22837378	9.00E-06	no asthma	1.18	NA	up to 3,368 European ancestry cases; up to 29,507 European ancestry controls	European(32875)	ALL(32875)	EUR(32875)	ALL(32875)	Airflow obstruction	HPOID:0006536	Obstructive lung disease	DOID:3083	chronic obstructive pulmonary disease	D000402	Airway Obstruction	EFOID:0003892	pulmonary function measurement	Chronic obstructive airway disease	NA	Research Support, N.I.H., Extramural	Meta-Analysis	Research Support, Non-U.S. Gov't
18	5604240	rs4798376	T	C	rs4798376	23990791	4.03E-05	imputed, conditional on PI S and Z alleles in GWAS stage only	0.03	NA	1,392 European ancestry individuals	European(1392)	ALL(1392)	EUR(1392)	ALL(1392)	Serum alpha1-antitrypsin levels	HPOID:0006510	Chronic obstructive pulmonary disease	DOID:3083	chronic obstructive pulmonary disease	NA	NA	NA	NA	Chronic obstructive airway disease	NA	Research Support, N.I.H., Extramural	Research Support, Non-U.S. Gov't	Research Support, U.S. Gov't, Non-P.H.S.
18	51093875	rs7233241	T	C	rs7233241	19300482	7.76E-05	NA	NA	NA	823 cases; 810 controls	NOPOP(1633)	ALL(1633)	NOPOP(1633)	ALL(1633)	Chronic obstructive pulmonary disease	HPOID:0006510	Chronic obstructive pulmonary disease	DOID:3083	chronic obstructive pulmonary disease	D029424	Pulmonary Disease, Chronic Obstructive	EFOID:0000341	chronic obstructive pulmonary disease	Chronic obstructive airway disease	NA	Research Support, N.I.H., Extramural	Research Support, U.S. Gov't, P.H.S.	Research Support, Non-U.S. Gov't
18	61877156	rs4534959	A	G	rs4534959	22837378	7.00E-07	FEV1 65%	1.72	NA	up to 3,368 European ancestry cases; up to 29,507 European ancestry controls	European(32875)	ALL(32875)	EUR(32875)	ALL(32875)	Airflow obstruction	HPOID:0006536	Obstructive lung disease	DOID:3083	chronic obstructive pulmonary disease	D000402	Airway Obstruction	EFOID:0003892	pulmonary function measurement	Chronic obstructive airway disease	NA	Research Support, N.I.H., Extramural	Meta-Analysis	Research Support, Non-U.S. Gov't
18	70227021	rs17086172	T	C	rs17086172	22837378	7.00E-06	no asthma	1.35	NA	up to 3,368 European ancestry cases; up to 29,507 European ancestry controls	European(32875)	ALL(32875)	EUR(32875)	ALL(32875)	Airflow obstruction	HPOID:0006536	Obstructive lung disease	DOID:3083	chronic obstructive pulmonary disease	D000402	Airway Obstruction	EFOID:0003892	pulmonary function measurement	Chronic obstructive airway disease	NA	Research Support, N.I.H., Extramural	Meta-Analysis	Research Support, Non-U.S. Gov't
18	71878517	rs9951925	C	A	rs9951925	23144326	2.00E-06	FG	NA	NA	Up to 1,951 European ancestry smokers	European(1951)	ALL(1951)	EUR(1951)	ALL(1951)	Chronic obstructive pulmonary disease-related biomarkers	HPOID:0006510	Chronic obstructive pulmonary disease	DOID:3083	chronic obstructive pulmonary disease	D029424	Pulmonary Disease, Chronic Obstructive	EFOID:0005080	surfactant protein D measurement	Chronic obstructive airway disease	rs9951925-C	Clinical Trial	Research Support, N.I.H., Extramural	Research Support, Non-U.S. Gov't
18	73309989	rs4263026	G	C	rs4263026	23990791	3.47E-05	imputed, conditional on PI S and Z alleles in GWAS stage only	0.03	NA	1,392 European ancestry individuals	European(1392)	ALL(1392)	EUR(1392)	ALL(1392)	Serum alpha1-antitrypsin levels	HPOID:0006510	Chronic obstructive pulmonary disease	DOID:3083	chronic obstructive pulmonary disease	NA	NA	NA	NA	Chronic obstructive airway disease	NA	Research Support, N.I.H., Extramural	Research Support, Non-U.S. Gov't	Research Support, U.S. Gov't, Non-P.H.S.
19	12752425	rs10411619	T	C	rs10411619	24383474	1.00E-09	(Hispanic)	0.18	[0.12-0.23] unit decrease	2,587 European ancestry individuals; 2,510 African American individuals; 2,113 Hispanic individuals; 704 Chinese ancestry individuals	Chinese(704)	African American(2510)	European(2587)	Hispanic(2113)	ALL(7914)	ASN(704)	HIS(2113)	AFR(2510)	EUR(2587)	ALL(7914)	Pulmonary emphysema	HPOID:0006510	Chronic obstructive pulmonary disease	DOID:9675	pulmonary emphysema	NA	NA	NA
19	12752425	rs10411619	T	C	rs10411619	24383474	6.70E-05	NA	0.05	[0.02-0.07] unit decrease	2,587 European ancestry individuals; 2,510 African American individuals; 2,113 Hispanic individuals; 704 Chinese ancestry individuals	Chinese(704)	African American(2510)	European(2587)	Hispanic(2113)	ALL(7914)	ASN(704)	HIS(2113)	AFR(2510)	EUR(2587)	ALL(7914)	Pulmonary emphysema	HPOID:0006510	Chronic obstructive pulmonary disease	DOID:9675	pulmonary emphysema	NA	NA	NA
19	14985805	rs16980016	G	A	rs16980016	19300482	7.95E-05	NA	NA	NA	823 cases; 810 controls	NOPOP(1633)	ALL(1633)	NOPOP(1633)	ALL(1633)	Chronic obstructive pulmonary disease	HPOID:0006510	Chronic obstructive pulmonary disease	DOID:3083	chronic obstructive pulmonary disease	D029424	Pulmonary Disease, Chronic Obstructive	EFOID:0000341	chronic obstructive pulmonary disease	Chronic obstructive airway disease	NA	Research Support, N.I.H., Extramural	Research Support, U.S. Gov't, P.H.S.	Research Support, Non-U.S. Gov't
19	18232754	rs11086090	G	T	rs11086090	23990791	5.74E-06	imputed, conditional on PI S and Z alleles in GWAS stage only	0.04	NA	1,392 European ancestry individuals	European(1392)	ALL(1392)	EUR(1392)	ALL(1392)	Serum alpha1-antitrypsin levels	HPOID:0006510	Chronic obstructive pulmonary disease	DOID:3083	chronic obstructive pulmonary disease	NA	NA	NA	NA	Chronic obstructive airway disease	NA	Research Support, N.I.H., Extramural	Research Support, Non-U.S. Gov't	Research Support, U.S. Gov't, Non-P.H.S.
19	18233195	rs12462442	G	A	rs12462442	23990791	5.74E-06	imputed, conditional on PI S and Z alleles in GWAS stage only	0.04	NA	1,392 European ancestry individuals	European(1392)	ALL(1392)	EUR(1392)	ALL(1392)	Serum alpha1-antitrypsin levels	HPOID:0006510	Chronic obstructive pulmonary disease	DOID:3083	chronic obstructive pulmonary disease	NA	NA	NA	NA	Chronic obstructive airway disease	NA	Research Support, N.I.H., Extramural	Research Support, Non-U.S. Gov't	Research Support, U.S. Gov't, Non-P.H.S.
19	18234005	rs12611216	G	A	rs12611216	23990791	1.01E-05	imputed, conditional on PI S and Z alleles in GWAS stage only	0.04	NA	1,392 European ancestry individuals	European(1392)	ALL(1392)	EUR(1392)	ALL(1392)	Serum alpha1-antitrypsin levels	HPOID:0006510	Chronic obstructive pulmonary disease	DOID:3083	chronic obstructive pulmonary disease	NA	NA	NA	NA	Chronic obstructive airway disease	NA	Research Support, N.I.H., Extramural	Research Support, Non-U.S. Gov't	Research Support, U.S. Gov't, Non-P.H.S.
19	18234567	rs740692	G	T	rs740692	23990791	1.74E-05	imputed, conditional on PI S and Z alleles in GWAS stage only	0.04	NA	1,392 European ancestry individuals	European(1392)	ALL(1392)	EUR(1392)	ALL(1392)	Serum alpha1-antitrypsin levels	HPOID:0006510	Chronic obstructive pulmonary disease	DOID:3083	chronic obstructive pulmonary disease	NA	NA	NA	NA	Chronic obstructive airway disease	NA	Research Support, N.I.H., Extramural	Research Support, Non-U.S. Gov't	Research Support, U.S. Gov't, Non-P.H.S.
19	18234639	rs740693	G	A	rs740693	23990791	2.59E-05	imputed, conditional on PI S and Z alleles in GWAS stage only	0.04	NA	1,392 European ancestry individuals	European(1392)	ALL(1392)	EUR(1392)	ALL(1392)	Serum alpha1-antitrypsin levels	HPOID:0006510	Chronic obstructive pulmonary disease	DOID:3083	chronic obstructive pulmonary disease	NA	NA	NA	NA	Chronic obstructive airway disease	NA	Research Support, N.I.H., Extramural	Research Support, Non-U.S. Gov't	Research Support, U.S. Gov't, Non-P.H.S.
19	18240298	rs12609740	G	A	rs12609740	23990791	4.16E-05	imputed, conditional on PI S and Z alleles in GWAS stage only	0.04	NA	1,392 European ancestry individuals	European(1392)	ALL(1392)	EUR(1392)	ALL(1392)	Serum alpha1-antitrypsin levels	HPOID:0006510	Chronic obstructive pulmonary disease	DOID:3083	chronic obstructive pulmonary disease	NA	NA	NA	NA	Chronic obstructive airway disease	NA	Research Support, N.I.H., Extramural	Research Support, Non-U.S. Gov't	Research Support, U.S. Gov't, Non-P.H.S.
19	41302706	rs7937	C	T	rs7937	22080838	3.00E-09	NA	1.37	[1.20-1.59]	3,499 European ancestry cases; 1,922 European ancestry controls	European(5421)	ALL(5421)	EUR(5421)	ALL(5421)	Chronic obstructive pulmonary disease	HPOID:0006510	Chronic obstructive pulmonary disease	DOID:3083	chronic obstructive pulmonary disease	D029424	Pulmonary Disease, Chronic Obstructive	EFOID:0000341	chronic obstructive pulmonary disease	Chronic obstructive airway disease	NA	Research Support, N.I.H., Extramural	Research Support, U.S. Gov't, P.H.S.	Meta-Analysis
20	7009158	rs16992973	G	A	rs16992973	22837378	1.26E-09	NA	NA	NA	up to 3,368 European ancestry cases; up to 29,507 European ancestry controls	European(32875)	ALL(32875)	EUR(32875)	ALL(32875)	Airflow obstruction	HPOID:0006536	Obstructive lung disease	DOID:3083	chronic obstructive pulmonary disease	D000402	Airway Obstruction	EFOID:0003892	pulmonary function measurement	Chronic obstructive airway disease	NA	Research Support, N.I.H., Extramural	Meta-Analysis	Research Support, Non-U.S. Gov't
20	19100148	rs2208796	G	A	rs2208796	22837378	2.69E-10	NA	NA	NA	up to 3,368 European ancestry cases; up to 29,507 European ancestry controls	European(32875)	ALL(32875)	EUR(32875)	ALL(32875)	Airflow obstruction	HPOID:0006536	Obstructive lung disease	DOID:3083	chronic obstructive pulmonary disease	D000402	Airway Obstruction	EFOID:0003892	pulmonary function measurement	Chronic obstructive airway disease	NA	Research Support, N.I.H., Extramural	Meta-Analysis	Research Support, Non-U.S. Gov't
20	55454659	rs6099314	A	G	rs6099314	24621683	4.00E-07	(AA)	NA	NA	5,812 European ancestry cases; 3,955 European ancestry controls; 821 African American cases; 1,749 African American controls	African American(2570)	European(9767)	ALL(12337)	AFR(2570)	EUR(9767)	ALL(12337)	Chronic obstructive pulmonary disease (moderate to severe)	HPOID:0006510	Chronic obstructive pulmonary disease	DOID:3083	chronic obstructive pulmonary disease	NA	NA	NA	NA	Chronic obstructive airway disease	NA	Research Support, N.I.H., Extramural
20	58894423	rs6100861	G	A	rs6100861	19300482	7.16E-05	NA	NA	NA	823 cases; 810 controls	NOPOP(1633)	ALL(1633)	NOPOP(1633)	ALL(1633)	Chronic obstructive pulmonary disease	HPOID:0006510	Chronic obstructive pulmonary disease	DOID:3083	chronic obstructive pulmonary disease	D029424	Pulmonary Disease, Chronic Obstructive	EFOID:0000341	chronic obstructive pulmonary disease	Chronic obstructive airway disease	NA	Research Support, N.I.H., Extramural	Research Support, U.S. Gov't, P.H.S.	Research Support, Non-U.S. Gov't
21	17667720	rs2823743	T	C	rs2823743	23144326	1.00E-06	IL6	NA	NA	Up to 1,951 European ancestry smokers	European(1951)	ALL(1951)	EUR(1951)	ALL(1951)	Chronic obstructive pulmonary disease-related biomarkers	HPOID:0006510	Chronic obstructive pulmonary disease	DOID:3083	chronic obstructive pulmonary disease	D029424	Pulmonary Disease, Chronic Obstructive	EFOID:0005080	surfactant protein D measurement	Chronic obstructive airway disease	rs2823743-C	Clinical Trial	Research Support, N.I.H., Extramural	Research Support, Non-U.S. Gov't
21	27716654	rs9975851	C	T	rs9975851	22837378	4.00E-06	No asthma	1.17	NA	up to 3,368 European ancestry cases; up to 29,507 European ancestry controls	European(32875)	ALL(32875)	EUR(32875)	ALL(32875)	Airflow obstruction	HPOID:0006536	Obstructive lung disease	DOID:3083	chronic obstructive pulmonary disease	D000402	Airway Obstruction	EFOID:0003892	pulmonary function measurement	Chronic obstructive airway disease	rs9975851-T	Research Support, N.I.H., Extramural	Meta-Analysis	Research Support, Non-U.S. Gov't
21	38694499	rs9978132	C	A	rs9978132	19300482	7.22E-05	NA	NA	NA	823 cases; 810 controls	NOPOP(1633)	ALL(1633)	NOPOP(1633)	ALL(1633)	Chronic obstructive pulmonary disease	HPOID:0006510	Chronic obstructive pulmonary disease	DOID:3083	chronic obstructive pulmonary disease	D029424	Pulmonary Disease, Chronic Obstructive	EFOID:0000341	chronic obstructive pulmonary disease	Chronic obstructive airway disease	NA	Research Support, N.I.H., Extramural	Research Support, U.S. Gov't, P.H.S.	Research Support, Non-U.S. Gov't
21	46583016	rs453176	T	C	rs453176	23990791	2.37E-05	imputed, conditional on PI S and Z alleles in GWAS stage only	0.06	NA	1,392 European ancestry individuals	European(1392)	ALL(1392)	EUR(1392)	ALL(1392)	Serum alpha1-antitrypsin levels	HPOID:0006510	Chronic obstructive pulmonary disease	DOID:3083	chronic obstructive pulmonary disease	NA	NA	NA	NA	Chronic obstructive airway disease	NA	Research Support, N.I.H., Extramural	Research Support, Non-U.S. Gov't	Research Support, U.S. Gov't, Non-P.H.S.
21	46584076	rs407550	G	C	rs407550	23990791	2.37E-05	imputed, conditional on PI S and Z alleles in GWAS stage only	0.06	NA	1,392 European ancestry individuals	European(1392)	ALL(1392)	EUR(1392)	ALL(1392)	Serum alpha1-antitrypsin levels	HPOID:0006510	Chronic obstructive pulmonary disease	DOID:3083	chronic obstructive pulmonary disease	NA	NA	NA	NA	Chronic obstructive airway disease	NA	Research Support, N.I.H., Extramural	Research Support, Non-U.S. Gov't	Research Support, U.S. Gov't, Non-P.H.S.
21	46593983	rs17004749	T	C	rs17004749	23990791	2.54E-05	imputed, conditional on PI S and Z alleles in GWAS stage only	0.06	NA	1,392 European ancestry individuals	European(1392)	ALL(1392)	EUR(1392)	ALL(1392)	Serum alpha1-antitrypsin levels	HPOID:0006510	Chronic obstructive pulmonary disease	DOID:3083	chronic obstructive pulmonary disease	NA	NA	NA	NA	Chronic obstructive airway disease	NA	Research Support, N.I.H., Extramural	Research Support, Non-U.S. Gov't	Research Support, U.S. Gov't, Non-P.H.S.
21	46597274	rs7279483	G	C	rs7279483	23990791	2.65E-05	imputed, conditional on PI S and Z alleles in GWAS stage only	0.06	NA	1,392 European ancestry individuals	European(1392)	ALL(1392)	EUR(1392)	ALL(1392)	Serum alpha1-antitrypsin levels	HPOID:0006510	Chronic obstructive pulmonary disease	DOID:3083	chronic obstructive pulmonary disease	NA	NA	NA	NA	Chronic obstructive airway disease	NA	Research Support, N.I.H., Extramural	Research Support, Non-U.S. Gov't	Research Support, U.S. Gov't, Non-P.H.S.
22	17590744	rs1468488	T	C	rs1468488	23990791	4.52E-05	imputed, conditional on PI S and Z alleles in GWAS stage only	0.03	NA	1,392 European ancestry individuals	European(1392)	ALL(1392)	EUR(1392)	ALL(1392)	Serum alpha1-antitrypsin levels	HPOID:0006510	Chronic obstructive pulmonary disease	DOID:3083	chronic obstructive pulmonary disease	NA	NA	NA	NA	Chronic obstructive airway disease	NA	Research Support, N.I.H., Extramural	Research Support, Non-U.S. Gov't	Research Support, U.S. Gov't, Non-P.H.S.
22	26337911	rs2269640	C	T	rs2269640	19300482	7.54E-05	NA	NA	NA	823 cases; 810 controls	NOPOP(1633)	ALL(1633)	NOPOP(1633)	ALL(1633)	Chronic obstructive pulmonary disease	HPOID:0006510	Chronic obstructive pulmonary disease	DOID:3083	chronic obstructive pulmonary disease	D029424	Pulmonary Disease, Chronic Obstructive	EFOID:0000341	chronic obstructive pulmonary disease	Chronic obstructive airway disease	NA	Research Support, N.I.H., Extramural	Research Support, U.S. Gov't, P.H.S.	Research Support, Non-U.S. Gov't
22	26653362	rs1207393	C	G	rs1207393	22837378	5.00E-06	FEV1 65%	1.19	NA	up to 3,368 European ancestry cases; up to 29,507 European ancestry controls	European(32875)	ALL(32875)	EUR(32875)	ALL(32875)	Airflow obstruction	HPOID:0006536	Obstructive lung disease	DOID:3083	chronic obstructive pulmonary disease	D000402	Airway Obstruction	EFOID:0003892	pulmonary function measurement	Chronic obstructive airway disease	NA	Research Support, N.I.H., Extramural	Meta-Analysis	Research Support, Non-U.S. Gov't
22	39984086	rs132577	A	T	rs132577	22837378	1.85E-08	NA	NA	NA	up to 3,368 European ancestry cases; up to 29,507 European ancestry controls	European(32875)	ALL(32875)	EUR(32875)	ALL(32875)	Airflow obstruction	HPOID:0006536	Obstructive lung disease	DOID:3083	chronic obstructive pulmonary disease	D000402	Airway Obstruction	EFOID:0003892	pulmonary function measurement	Chronic obstructive airway disease	NA	Research Support, N.I.H., Extramural	Meta-Analysis	Research Support, Non-U.S. Gov't

Mapped by lexical matching(Total Items:0)
(Waiting for update.)

Mapped by homologous gene(Total Items:0)
(Waiting for update.)

Chemical(Total Drugs:7)
CUI	ChemicalName	ChemicalID	CasRN	DiseaseName	DiseaseID	DirectEvidence	PubMedIDs
C0024117	enalapril	D004656	75847-73-3	pulmonary disease, chronic obstructive	MESH:D029424	therapeutic	20096799
C0024117	glycopyrrolate	D006024	596-51-0	pulmonary disease, chronic obstructive	MESH:D029424	therapeutic	21870878
C0024117	methotrexate	D008727	1959/5/2	pulmonary disease, chronic obstructive	MESH:D029424	therapeutic	1450620
C0024117	norepinephrine	D009638	51-41-2	pulmonary disease, chronic obstructive	MESH:D029424	marker/mechanism	18068611
C0024117	theophylline	D013806	58-55-9	pulmonary disease, chronic obstructive	MESH:D029424	therapeutic	1546832
C0024117	timolol	D013999	26839-75-8	pulmonary disease, chronic obstructive	MESH:D029424	marker/mechanism	7402590
C0024117	zafirlukast	C062735	107753-78-6	pulmonary disease, chronic obstructive	MESH:D029424	therapeutic	12781059

FDA approved drug and dosage information(Total Drugs:0)
(Waiting for update.)

FDA labeling changes(Total Drugs:0)
(Waiting for update.)