Home Contact Sitemap

PedAM

Pediatric Disease Annotations & Medicines



   psoriatic arthritis
  

Disease ID 663
Disease psoriatic arthritis
Definition
A type of inflammatory arthritis associated with PSORIASIS, often involving the axial joints and the peripheral terminal interphalangeal joints. It is characterized by the presence of HLA-B27-associated SPONDYLARTHROPATHY, and the absence of rheumatoid factor.
Synonym
arthritic psoriasis
arthritis psoriatic
arthritis psoriatica
arthritis psoriatics
arthritis, psoriatic
arthritis, psoriatic [disease/finding]
arthropathic psoriasis
arthropathies, psoriatic
arthropathy, psoriatic
pa (psoriatic arthritis)
pa - psoriatic arthritis
psa (psoriatic arthritis)
psa - psoriatic arthritis
psoriasis arthropathic
psoriasis arthropathica
psoriasis arthropathy
psoriasis with arthropathy
psoriasis with arthropathy (disorder)
psoriasis, arthritic
psoriasis, arthropathic
psoriatic arthritis (disorder)
psoriatic arthropathies
psoriatic arthropathy
psoriatic arthropathy nos
psoriatic arthropathy nos (disorder)
DOID
UMLS
C0003872
MeSH
SNOMED-CT
Comorbidity
UMLS | Disease | Sentences' Count(Total Sentences:83)
C0033860  |  psoriasis  |  53
C0021831  |  bowel disease  |  9
C0021390  |  inflammatory bowel disease  |  8
C0003864  |  arthritis  |  7
C0042373  |  vascular disease  |  6
C0007222  |  cardiovascular disease  |  6
C0004153  |  atherosclerosis  |  5
C0011847  |  diabetes  |  4
C0003873  |  rheumatoid arthritis  |  4
C0038012  |  spondylitis  |  4
C0948265  |  metabolic syndrome  |  3
C0021053  |  immune disease  |  3
C0039103  |  synovitis  |  3
C0003864  |  inflammatory arthritis  |  3
C0042164  |  uveitis  |  2
C0029456  |  osteoporosis  |  2
C0022408  |  joint disease  |  2
C0021390  |  inflammatory bowel diseases  |  2
C0242490  |  enthesopathy  |  2
C0011570  |  depression  |  2
C0031090  |  periodontal disease  |  1
C0003467  |  anxiety  |  1
C0035078  |  renal failure  |  1
C0041296  |  tuberculosis  |  1
C0019360  |  zoster  |  1
C0334590  |  anaplastic oligodendroglioma  |  1
C0036205  |  pulmonary sarcoidosis  |  1
C0042870  |  vitamin d deficiency  |  1
C0158322  |  calcaneal spur  |  1
C0020443  |  hypercholesterolemia  |  1
C0029401  |  paget's disease  |  1
C0032285  |  pneumonitis  |  1
C0027051  |  myocardial infarction  |  1
C0020498  |  diffuse idiopathic skeletal hyperostosis (dish)  |  1
C0020498  |  diffuse idiopathic skeletal hyperostosis  |  1
C0079731  |  b-cell lymphoma  |  1
C0027051  |  myocardial infarct  |  1
C0003509  |  aortitis  |  1
C0015397  |  eye disease  |  1
C0009782  |  connective tissue disease  |  1
C0020492  |  hyperostosis  |  1
C0036202  |  sarcoid  |  1
C0028754  |  obesity  |  1
C0021400  |  influenza  |  1
C0026769  |  multiple sclerosis  |  1
C0030312  |  pancytopenia  |  1
C0033953  |  sexual dysfunction  |  1
C0002171  |  alopecia areata  |  1
C0002170  |  alopecia  |  1
C0022408  |  articular disease  |  1
C0042870  |  vitamin d defic  |  1
C0520679  |  obstructive sleep apnea  |  1
C0034069  |  pulmonary fibrosis  |  1
C0024115  |  pulmonary disease  |  1
C0018099  |  gout  |  1
C0011849  |  diabetes mellitus  |  1
C0007959  |  charcot-marie-tooth disease  |  1
C0019163  |  hepatitis b  |  1
C0242647  |  marginal zone b-cell lymphoma  |  1
C0036202  |  sarcoidosis  |  1
C0022661  |  chronic renal failure  |  1
C1136085  |  monoclonal gammopathy  |  1
C0878544  |  cardiomyopathy  |  1
C0949690  |  spondyloarthritis  |  1
C0023798  |  lipoma  |  1
C0009782  |  connective tissue diseases  |  1
C0022073  |  iridocyclitis  |  1
C0025235  |  melkersson-rosenthal syndrome  |  1
C0019158  |  hepatitis  |  1
C0007193  |  dilated cardiomyopathy  |  1
C0042373  |  vascular diseases  |  1
C0024299  |  lymphoma  |  1
C0442874  |  neuropathy  |  1
C0019655  |  histoplasmosis  |  1
C1956089  |  osteophyte  |  1
C0007570  |  celiac disease  |  1
C0007222  |  cardiovascular diseases  |  1
C0016053  |  fibromyalgia  |  1
C0014118  |  endocarditis  |  1
C0026975  |  myelitis  |  1
C0005940  |  bone disease  |  1
C0019196  |  hepatitis c  |  1
C0037315  |  sleep apnea  |  1
Curated Gene
Entrez_id | Symbol | Resource(Total Genes:22)
HLA-DRB1  |  3123  |  GHR
TNF  |  7124  |  CTD_human
CD68  |  968  |  CTD_human
IL13  |  3596  |  GHR
NOD2  |  64127  |  CTD_human
BMP4  |  652  |  CTD_human
RUNX2  |  860  |  CTD_human
NOS2  |  4843  |  CTD_human
HLA-B  |  3106  |  GHR
IL12B  |  3593  |  CTD_human;GHR
HLA-C  |  3107  |  CTD_human;GWASCAT;GHR
IL23R  |  149233  |  GHR
NR4A2  |  4929  |  CTD_human
TRAF3IP2-AS1  |  643749  |  GWASCAT
LTA  |  4049  |  CTD_human
CARD14  |  79092  |  GHR
MEFV  |  4210  |  CTD_human
FBXL19  |  54620  |  CTD_human
REL  |  5966  |  GWASCAT
CXCL8  |  3576  |  CTD_human
TRAF3IP2  |  10758  |  CTD_human;GWASCAT;GHR
LINC01185  |  400957  |  GWASCAT
Inferring Gene
Entrez_id | Symbol | Resource(Total Genes:35)
3106  |  HLA-B  |  infer
3107  |  HLA-C  |  infer
3123  |  HLA-DRB1  |  infer
3593  |  IL12B  |  infer
100507436  |  MICA  |  infer
4277  |  MICB  |  infer
4790  |  NFKB1  |  infer
5966  |  REL  |  infer
100270953  |  RPL21P33  |  infer
7124  |  TNF  |  infer
10758  |  TRAF3IP2  |  infer
7421  |  VDR  |  infer
1493  |  CTLA4  |  infer
1543  |  CYP1A1  |  infer
1950  |  EGF  |  infer
2246  |  FGF1  |  infer
2247  |  FGF2  |  infer
3105  |  HLA-A  |  infer
3552  |  IL1A  |  infer
3553  |  IL1B  |  infer
3802  |  KIR2DL1  |  infer
3803  |  KIR2DL2  |  infer
3804  |  KIR2DL3  |  infer
3806  |  KIR2DS1  |  infer
100132285  |  KIR2DS2  |  infer
4049  |  LTA  |  infer
170679  |  PSORS1C1  |  infer
10547  |  PSORS4  |  infer
63870  |  PSORS5  |  infer
26191  |  PTPN22  |  infer
6648  |  SOD2  |  infer
7132  |  TNFRSF1A  |  infer
7133  |  TNFRSF1B  |  infer
7157  |  TP53  |  infer
7422  |  VEGFA  |  infer
Text Mined Gene
Entrez_id | Symbol | Score | Resource(Total Genes:236)
11183  |  MAP4K5  |  DISEASES
7132  |  TNFRSF1A  |  DISEASES
6583  |  SLC22A4  |  DISEASES
3956  |  LGALS1  |  DISEASES
4792  |  NFKBIA  |  DISEASES
7076  |  TIMP1  |  DISEASES
4313  |  MMP2  |  DISEASES
84560  |  MT4  |  DISEASES
1723  |  DHODH  |  DISEASES
4210  |  MEFV  |  DISEASES
8797  |  TNFRSF10A  |  DISEASES
10148  |  EBI3  |  DISEASES
973  |  CD79A  |  DISEASES
1311  |  COMP  |  DISEASES
10135  |  NAMPT  |  DISEASES
5919  |  RARRES2  |  DISEASES
6348  |  CCL3  |  DISEASES
6347  |  CCL2  |  DISEASES
3558  |  IL2  |  DISEASES
51561  |  IL23A  |  DISEASES
3458  |  IFNG  |  DISEASES
3565  |  IL4  |  DISEASES
3554  |  IL1R1  |  DISEASES
5657  |  PRTN3  |  DISEASES
7128  |  TNFAIP3  |  DISEASES
8600  |  TNFSF11  |  DISEASES
55905  |  RNF114  |  DISEASES
3581  |  IL9R  |  DISEASES
80352  |  RNF39  |  DISEASES
718  |  C3  |  DISEASES
968  |  CD68  |  DISEASES
6351  |  CCL4  |  DISEASES
6382  |  SDC1  |  DISEASES
1401  |  CRP  |  DISEASES
1116  |  CHI3L1  |  DISEASES
301  |  ANXA1  |  DISEASES
3569  |  IL6  |  DISEASES
3557  |  IL1RN  |  DISEASES
26525  |  IL36RN  |  DISEASES
27177  |  IL36B  |  DISEASES
6366  |  CCL21  |  DISEASES
170679  |  PSORS1C1  |  DISEASES
7097  |  TLR2  |  DISEASES
6741  |  SSB  |  DISEASES
4069  |  LYZ  |  DISEASES
7188  |  TRAF5  |  DISEASES
5687  |  PSMA6  |  DISEASES
6095  |  RORA  |  DISEASES
84888  |  SPPL2A  |  DISEASES
3595  |  IL12RB2  |  DISEASES
9368  |  SLC9A3R1  |  DISEASES
64377  |  CHST8  |  DISEASES
443  |  ASPA  |  DISEASES
27178  |  IL37  |  DISEASES
3552  |  IL1A  |  DISEASES
3553  |  IL1B  |  DISEASES
8190  |  MIA  |  DISEASES
64135  |  IFIH1  |  DISEASES
9410  |  SNRNP40  |  DISEASES
8491  |  MAP4K3  |  DISEASES
4162  |  MCAM  |  DISEASES
8942  |  KYNU  |  DISEASES
941  |  CD80  |  DISEASES
8808  |  IL1RL2  |  DISEASES
84162  |  KIAA1109  |  DISEASES
6774  |  STAT3  |  DISEASES
5443  |  POMC  |  DISEASES
7297  |  TYK2  |  DISEASES
3383  |  ICAM1  |  DISEASES
6897  |  TARS  |  DISEASES
1390  |  CREM  |  DISEASES
593  |  BCKDHA  |  DISEASES
150094  |  SIK1  |  DISEASES
5141  |  PDE4A  |  DISEASES
84467  |  FBN3  |  DISEASES
3697  |  ITIH1  |  DISEASES
3578  |  IL9  |  DISEASES
8973  |  CHRNA6  |  DISEASES
3439  |  IFNA1  |  DISEASES
1436  |  CSF1R  |  DISEASES
6750  |  SST  |  DISEASES
146433  |  IL34  |  DISEASES
1142  |  CHRNB3  |  DISEASES
115653  |  KIR3DL3  |  DISEASES
401827  |  MSLNL  |  DISEASES
5871  |  MAP4K2  |  DISEASES
7412  |  VCAM1  |  DISEASES
2215  |  FCGR3B  |  DISEASES
5966  |  REL  |  DISEASES
83932  |  SPRTN  |  DISEASES
84818  |  IL17RC  |  DISEASES
3693  |  ITGB5  |  DISEASES
132612  |  ADAD1  |  DISEASES
3600  |  IL15  |  DISEASES
51752  |  ERAP1  |  DISEASES
4982  |  TNFRSF11B  |  DISEASES
81501  |  DCSTAMP  |  DISEASES
84659  |  RNASE7  |  DISEASES
79841  |  AGBL2  |  DISEASES
4314  |  MMP3  |  DISEASES
64127  |  NOD2  |  DISEASES
4218  |  RAB8A  |  DISEASES
3816  |  KLK1  |  DISEASES
5617  |  PRL  |  DISEASES
9101  |  USP8  |  DISEASES
1493  |  CTLA4  |  DISEASES
3596  |  IL13  |  DISEASES
23636  |  NUP62  |  DISEASES
3627  |  CXCL10  |  DISEASES
196374  |  KRT78  |  DISEASES
56246  |  MRAP  |  DISEASES
57521  |  RPTOR  |  DISEASES
285  |  ANGPT2  |  DISEASES
1604  |  CD55  |  DISEASES
51268  |  PIPOX  |  DISEASES
10318  |  TNIP1  |  DISEASES
4684  |  NCAM1  |  DISEASES
3183  |  HNRNPC  |  DISEASES
23765  |  IL17RA  |  DISEASES
149233  |  IL23R  |  DISEASES
4312  |  MMP1  |  DISEASES
3590  |  IL11RA  |  DISEASES
6097  |  RORC  |  DISEASES
1435  |  CSF1  |  DISEASES
388121  |  TNFAIP8L3  |  DISEASES
64806  |  IL25  |  DISEASES
1260  |  CNGA2  |  DISEASES
50616  |  IL22  |  DISEASES
5271  |  SERPINB8  |  DISEASES
6401  |  SELE  |  DISEASES
942  |  CD86  |  DISEASES
5142  |  PDE4B  |  DISEASES
59307  |  SIGIRR  |  DISEASES
353144  |  LCE3C  |  DISEASES
353142  |  LCE3A  |  DISEASES
256394  |  SERPINA11  |  DISEASES
353143  |  LCE3B  |  DISEASES
3802  |  KIR2DL1  |  DISEASES
112744  |  IL17F  |  DISEASES
7189  |  TRAF6  |  DISEASES
7180  |  CRISP2  |  DISEASES
1235  |  CCR6  |  DISEASES
55893  |  ZNF395  |  DISEASES
126364  |  LRRC25  |  DISEASES
84639  |  IL1F10  |  DISEASES
3716  |  JAK1  |  DISEASES
3605  |  IL17A  |  DISEASES
79092  |  CARD14  |  DISEASES
5265  |  SERPINA1  |  DISEASES
283420  |  CLEC9A  |  DISEASES
3240  |  HP  |  DISEASES
55544  |  RBM38  |  DISEASES
3899  |  AFF3  |  DISEASES
6288  |  SAA1  |  DISEASES
3683  |  ITGAL  |  DISEASES
125893  |  ZNF816  |  DISEASES
26151  |  NAT9  |  DISEASES
6775  |  STAT4  |  DISEASES
6364  |  CCL20  |  DISEASES
9332  |  CD163  |  DISEASES
26191  |  PTPN22  |  DISEASES
4892  |  NRAP  |  DISEASES
3123  |  HLA-DRB1  |  DISEASES
4283  |  CXCL9  |  DISEASES
6993  |  DYNLT1  |  DISEASES
6738  |  TROVE2  |  DISEASES
10090  |  UST  |  DISEASES
2214  |  FCGR3A  |  DISEASES
632  |  BGLAP  |  DISEASES
6283  |  S100A12  |  DISEASES
6280  |  S100A9  |  DISEASES
10758  |  TRAF3IP2  |  DISEASES
84648  |  LCE3D  |  DISEASES
2312  |  FLG  |  DISEASES
914  |  CD2  |  DISEASES
965  |  CD58  |  DISEASES
4803  |  NGF  |  DISEASES
55118  |  CRTAC1  |  DISEASES
959  |  CD40LG  |  DISEASES
2239  |  GPC4  |  DISEASES
7422  |  VEGFA  |  DISEASES
958  |  CD40  |  DISEASES
729238  |  SFTPA2  |  DISEASES
4318  |  MMP9  |  DISEASES
2833  |  CXCR3  |  DISEASES
7321  |  UBE2D1  |  DISEASES
22943  |  DKK1  |  DISEASES
7099  |  TLR4  |  DISEASES
11326  |  VSIG4  |  DISEASES
3127  |  HLA-DRB5  |  DISEASES
3376  |  IARS  |  DISEASES
50943  |  FOXP3  |  DISEASES
100507436  |  MICA  |  DISEASES
3107  |  HLA-C  |  DISEASES
7133  |  TNFRSF1B  |  DISEASES
29968  |  PSAT1  |  DISEASES
3105  |  HLA-A  |  DISEASES
51131  |  PHF11  |  DISEASES
10186  |  LHFP  |  DISEASES
54620  |  FBXL19  |  DISEASES
90865  |  IL33  |  DISEASES
2706  |  GJB2  |  DISEASES
10288  |  LILRB2  |  DISEASES
11202  |  KLK8  |  DISEASES
5901  |  RAN  |  DISEASES
78996  |  C7orf49  |  DISEASES
84561  |  SLC12A8  |  DISEASES
5627  |  PROS1  |  DISEASES
6387  |  CXCL12  |  DISEASES
54535  |  CCHCR1  |  DISEASES
11184  |  MAP4K1  |  DISEASES
3803  |  KIR2DL2  |  DISEASES
4148  |  MATN3  |  DISEASES
23198  |  PSME4  |  DISEASES
176  |  ACAN  |  DISEASES
10093  |  ARPC4  |  DISEASES
340351  |  AGBL3  |  DISEASES
3718  |  JAK3  |  DISEASES
653509  |  SFTPA1  |  DISEASES
57511  |  COG6  |  DISEASES
7124  |  TNF  |  DISEASES
3106  |  HLA-B  |  DISEASES
3594  |  IL12RB1  |  DISEASES
4049  |  LTA  |  DISEASES
23228  |  PLCL2  |  DISEASES
3586  |  IL10  |  DISEASES
5478  |  PPIA  |  DISEASES
58494  |  JAM2  |  DISEASES
345778  |  MTX3  |  DISEASES
930  |  CD19  |  DISEASES
3684  |  ITGAM  |  DISEASES
11331  |  PHB2  |  DISEASES
8742  |  TNFSF12  |  DISEASES
26085  |  KLK13  |  DISEASES
10866  |  HCP5  |  DISEASES
79104  |  MEG8  |  DISEASES
Locus(Waiting for update.)
Disease ID 663
Disease psoriatic arthritis
Integrated Phenotype(Waiting for update.)
Text Mined Phenotype
HPO | Name | Sentences' Count(Total Phenotypes:50)
HP:0003765  |  Psoriasis  |  53
HP:0001369  |  Arthritis  |  7
HP:0100686  |  Enthesitis  |  7
HP:0002621  |  Atherosclerosis  |  5
HP:0012531  |  Pain  |  4
HP:0001370  |  Rheumatoid arthritis  |  4
HP:0002960  |  Autoimmune condition  |  3
HP:0100769  |  Synovitis  |  3
HP:0002664  |  Neoplasia  |  2
HP:0000939  |  Osteoporosis  |  2
HP:0000554  |  Uveitis  |  2
HP:0000716  |  Depression  |  2
HP:0012378  |  Fatigue  |  1
HP:0012191  |  B-cell lymphoma  |  1
HP:0012115  |  Liver inflammation  |  1
HP:0002229  |  Alopecia areata  |  1
HP:0001876  |  Low blood cell count  |  1
HP:0003124  |  Elevated serum cholesterol  |  1
HP:0001644  |  Congestive cardiomyopathy  |  1
HP:0001658  |  Myocardial infarction  |  1
HP:0002206  |  Pulmonary fibrosis  |  1
HP:0012060  |  Acral lentiginous melanoma  |  1
HP:0000819  |  Diabetes mellitus  |  1
HP:0100584  |  Endocarditis  |  1
HP:0000739  |  Anxiety  |  1
HP:0100774  |  Hyperostosis  |  1
HP:0001513  |  Obesity  |  1
HP:0000969  |  Dropsy  |  1
HP:0012486  |  Inflammation of spinal cord  |  1
HP:0002829  |  Arthralgias  |  1
HP:0001298  |  Encephalopathy  |  1
HP:0001596  |  Hair loss  |  1
HP:0000083  |  Renal insufficiency  |  1
HP:0002996  |  Decreased elbow mobility  |  1
HP:0008404  |  Dystrophic nails  |  1
HP:0010535  |  Sleep apnea  |  1
HP:0002870  |  Obstructive sleep apnea  |  1
HP:0003493  |  Elevated antinuclear antibody  |  1
HP:0002608  |  Celiac disease  |  1
HP:0001094  |  Iridocyclitis  |  1
HP:0002910  |  Elevated transaminases  |  1
HP:0003774  |  End-stage renal failure  |  1
HP:0002665  |  Lymphoma  |  1
HP:0001638  |  Cardiomyopathy  |  1
HP:0100665  |  Angiooedema  |  1
HP:0001997  |  Gout  |  1
HP:0002459  |  Dysautonomia  |  1
HP:0002104  |  Absence of spontaneous respiration  |  1
HP:0100512  |  Vitamin D deficiency  |  1
HP:0012032  |  Lipoma  |  1
Disease ID 663
Disease psoriatic arthritis
Manually Symptom(Waiting for update.)
Text Mined Symptom
UMLS | Name | Sentences' Count(Total Symptoms:27)
C0033860  |  psoriasis  |  53
C1282952  |  enthesitis  |  7
C0239161  |  dactylitis  |  5
C0004153  |  atherosclerosis  |  5
C0030193  |  pain  |  4
C0038012  |  spondylitis  |  4
C0948265  |  metabolic syndrome  |  3
C0003864  |  inflammatory arthritis  |  3
C0009450  |  infection  |  3
C0039103  |  synovitis  |  3
C0029456  |  osteoporosis  |  2
C0027339  |  nail disease  |  2
C0037284  |  skin lesions  |  2
C0042164  |  uveitis  |  2
C0856169  |  endothelial dysfunction  |  2
C0022408  |  joint disease  |  2
C0032285  |  pneumonitis  |  1
C0013604  |  oedema  |  1
C0574960  |  sacroiliitis  |  1
C0015672  |  fatigue  |  1
C0221260  |  nail dystrophy  |  1
C0014118  |  endocarditis  |  1
C0034069  |  pulmonary fibrosis  |  1
C0333243  |  pitting oedema  |  1
C1301700  |  cardiovascular morbidity  |  1
C0270627  |  acute transverse myelitis  |  1
C0238790  |  bone destruction  |  1
Manually Genotype(Total Text Mining Genotypes:0)
(Waiting for update.)
All Snps(Total Genotypes:44)
snpId pubmedId geneId geneSymbol diseaseId sourceId sentence score Year geneSymbol_dbSNP CHROMOSOME POS REF ALT
rs10181656223287383798KIF5Aumls:C0003872BeFreeSignificant evidence for association with susceptibility to PsA was found toa SNP mapping to the REL (rs13017599, p(trend)=5.2×10(4)) gene, while nominal evidence for association (p(trend)<0.05) was found to seven other loci including PLCL2 (rs4535211, p=1.7×10(-3)); STAT4 (rs10181656, p=3.0×10(-3)) and the AFF3, CD28, CCL21, IL2 and KIF5A loci.0.0002714422012STAT42191105153GC
rs10181656223287386366CCL21umls:C0003872BeFreeSignificant evidence for association with susceptibility to PsA was found toa SNP mapping to the REL (rs13017599, p(trend)=5.2×10(4)) gene, while nominal evidence for association (p(trend)<0.05) was found to seven other loci including PLCL2 (rs4535211, p=1.7×10(-3)); STAT4 (rs10181656, p=3.0×10(-3)) and the AFF3, CD28, CCL21, IL2 and KIF5A loci.0.0002714422012STAT42191105153GC
rs10181656223287386775STAT4umls:C0003872BeFreeSignificant evidence for association with susceptibility to PsA was found toa SNP mapping to the REL (rs13017599, p(trend)=5.2×10(4)) gene, while nominal evidence for association (p(trend)<0.05) was found to seven other loci including PLCL2 (rs4535211, p=1.7×10(-3)); STAT4 (rs10181656, p=3.0×10(-3)) and the AFF3, CD28, CCL21, IL2 and KIF5A loci.0.0002714422012STAT42191105153GC
rs10181656223287383899AFF3umls:C0003872BeFreeSignificant evidence for association with susceptibility to PsA was found toa SNP mapping to the REL (rs13017599, p(trend)=5.2×10(4)) gene, while nominal evidence for association (p(trend)<0.05) was found to seven other loci including PLCL2 (rs4535211, p=1.7×10(-3)); STAT4 (rs10181656, p=3.0×10(-3)) and the AFF3, CD28, CCL21, IL2 and KIF5A loci.0.0005428842012STAT42191105153GC
rs10181656223287383558IL2umls:C0003872BeFreeSignificant evidence for association with susceptibility to PsA was found toa SNP mapping to the REL (rs13017599, p(trend)=5.2×10(4)) gene, while nominal evidence for association (p(trend)<0.05) was found to seven other loci including PLCL2 (rs4535211, p=1.7×10(-3)); STAT4 (rs10181656, p=3.0×10(-3)) and the AFF3, CD28, CCL21, IL2 and KIF5A loci.0.0005428842012STAT42191105153GC
rs1018165622328738940CD28umls:C0003872BeFreeSignificant evidence for association with susceptibility to PsA was found toa SNP mapping to the REL (rs13017599, p(trend)=5.2×10(4)) gene, while nominal evidence for association (p(trend)<0.05) was found to seven other loci including PLCL2 (rs4535211, p=1.7×10(-3)); STAT4 (rs10181656, p=3.0×10(-3)) and the AFF3, CD28, CCL21, IL2 and KIF5A loci.0.0002714422012STAT42191105153GC
rs101816562232873823228PLCL2umls:C0003872BeFreeSignificant evidence for association with susceptibility to PsA was found toa SNP mapping to the REL (rs13017599, p(trend)=5.2×10(4)) gene, while nominal evidence for association (p(trend)<0.05) was found to seven other loci including PLCL2 (rs4535211, p=1.7×10(-3)); STAT4 (rs10181656, p=3.0×10(-3)) and the AFF3, CD28, CCL21, IL2 and KIF5A loci.0.0002714422012STAT42191105153GC
rs111718062367328451561IL23Aumls:C0003872BeFreeAssociation study in Romanians confirms IL23A gene haplotype block rs2066808/rs11171806 as conferring risk to psoriatic arthritis.0.0070773522013IL23A1256339747GA
rs11209026190403065079PAX5umls:C0003872BeFreeAll 3-marker sliding windows containing SNP rs11209026 were associated with PsA (p=0.02 for all 3 windows).0.0002714422009IL23R167240275GA
rs12188300209531863593IL12Bumls:C0003872GAD[We replicated PsA associations at HLA-C and IL12B and identified a new association at TRAF3IP2 (rs13190932, P = 8.56 A 10a>>A1a*).]0.1351783392010NA5159402519AT
rs13017599223287383798KIF5Aumls:C0003872BeFreeSignificant evidence for association with susceptibility to PsA was found toa SNP mapping to the REL (rs13017599, p(trend)=5.2×10(4)) gene, while nominal evidence for association (p(trend)<0.05) was found to seven other loci including PLCL2 (rs4535211, p=1.7×10(-3)); STAT4 (rs10181656, p=3.0×10(-3)) and the AFF3, CD28, CCL21, IL2 and KIF5A loci.0.0002714422012NA260937196GA
rs13017599223287386366CCL21umls:C0003872BeFreeSignificant evidence for association with susceptibility to PsA was found toa SNP mapping to the REL (rs13017599, p(trend)=5.2×10(4)) gene, while nominal evidence for association (p(trend)<0.05) was found to seven other loci including PLCL2 (rs4535211, p=1.7×10(-3)); STAT4 (rs10181656, p=3.0×10(-3)) and the AFF3, CD28, CCL21, IL2 and KIF5A loci.0.0002714422012NA260937196GA
rs13017599221704935966RELumls:C0003872GWASCATGenome-wide meta-analysis of psoriatic arthritis identifies susceptibility locus at REL.0.1234527992012NA260937196GA
rs13017599223287383558IL2umls:C0003872BeFreeSignificant evidence for association with susceptibility to PsA was found toa SNP mapping to the REL (rs13017599, p(trend)=5.2×10(4)) gene, while nominal evidence for association (p(trend)<0.05) was found to seven other loci including PLCL2 (rs4535211, p=1.7×10(-3)); STAT4 (rs10181656, p=3.0×10(-3)) and the AFF3, CD28, CCL21, IL2 and KIF5A loci.0.0005428842012NA260937196GA
rs13017599223287386775STAT4umls:C0003872BeFreeSignificant evidence for association with susceptibility to PsA was found toa SNP mapping to the REL (rs13017599, p(trend)=5.2×10(4)) gene, while nominal evidence for association (p(trend)<0.05) was found to seven other loci including PLCL2 (rs4535211, p=1.7×10(-3)); STAT4 (rs10181656, p=3.0×10(-3)) and the AFF3, CD28, CCL21, IL2 and KIF5A loci.0.0002714422012NA260937196GA
rs13017599223287383899AFF3umls:C0003872BeFreeSignificant evidence for association with susceptibility to PsA was found toa SNP mapping to the REL (rs13017599, p(trend)=5.2×10(4)) gene, while nominal evidence for association (p(trend)<0.05) was found to seven other loci including PLCL2 (rs4535211, p=1.7×10(-3)); STAT4 (rs10181656, p=3.0×10(-3)) and the AFF3, CD28, CCL21, IL2 and KIF5A loci.0.0005428842012NA260937196GA
rs130175992232873823228PLCL2umls:C0003872BeFreeSignificant evidence for association with susceptibility to PsA was found toa SNP mapping to the REL (rs13017599, p(trend)=5.2×10(4)) gene, while nominal evidence for association (p(trend)<0.05) was found to seven other loci including PLCL2 (rs4535211, p=1.7×10(-3)); STAT4 (rs10181656, p=3.0×10(-3)) and the AFF3, CD28, CCL21, IL2 and KIF5A loci.0.0002714422012NA260937196GA
rs13017599221704935966RELumls:C0003872GAD[Genome-wide meta-analysis of psoriatic arthritis identifies susceptibility locus at REL.]0.1234527992012NA260937196GA
rs1301759922328738940CD28umls:C0003872BeFreeSignificant evidence for association with susceptibility to PsA was found toa SNP mapping to the REL (rs13017599, p(trend)=5.2×10(4)) gene, while nominal evidence for association (p(trend)<0.05) was found to seven other loci including PLCL2 (rs4535211, p=1.7×10(-3)); STAT4 (rs10181656, p=3.0×10(-3)) and the AFF3, CD28, CCL21, IL2 and KIF5A loci.0.0002714422012NA260937196GA
rs13190932209531863593IL12Bumls:C0003872BeFreeWe replicated PsA associations at HLA-C and IL12B and identified a new association at TRAF3IP2 (rs13190932, P = 8.56 × 10⁻¹⁷).0.1351783392010TRAF3IP2;TRAF3IP2-AS16111591867GA
rs13190932209531863107HLA-Cumls:C0003872BeFreeWe replicated PsA associations at HLA-C and IL12B and identified a new association at TRAF3IP2 (rs13190932, P = 8.56 × 10⁻¹⁷).0.2894784992010TRAF3IP2;TRAF3IP2-AS16111591867GA
rs13191343209531863107HLA-Cumls:C0003872GWASCATWe replicated PsA associations at HLA-C and IL12B and identified a new association at TRAF3IP2 (rs13190932, P = 8.56 × 10⁻¹⁷).0.2894784992010HLA-C;LOC101929772631273332CG,T
rs13191343209531863107HLA-Cumls:C0003872GAD[We replicated PsA associations at HLA-C and IL12B and identified a new association at TRAF3IP2 (rs13190932, P = 8.56 A 10a>>A1a*).]0.2894784992010HLA-C;LOC101929772631273332CG,T
rs1801282246975665468PPARGumls:C0003872BeFreeMeta-analysis of associations between the peroxisome proliferator-activated receptor-γ Pro12Ala polymorphism and susceptibility to nonalcoholic fatty liver disease, rheumatoid arthritis, and psoriatic arthritis.0.0029099162014PPARG312351626CG
rs1805192246975665468PPARGumls:C0003872BeFreeMeta-analysis of associations between the peroxisome proliferator-activated receptor-γ Pro12Ala polymorphism and susceptibility to nonalcoholic fatty liver disease, rheumatoid arthritis, and psoriatic arthritis.0.0029099162014PPARG312379739CG
rs20668082367328451561IL23Aumls:C0003872BeFreeAssociation study in Romanians confirms IL23A gene haplotype block rs2066808/rs11171806 as conferring risk to psoriatic arthritis.0.0070773522013STAT21256344189AG
rs220184124910145149233IL23Rumls:C0003872BeFreeIL-23R gene polymorphism rs2201841 is associated with psoriatic arthritis.0.0157212222014IL23R167228519AG
rs2631367162550506584SLC22A5umls:C0003872BeFreeIn contrast, a functional SNP mapping to the promoter region of SLC22A5 (rs2631367) was associated with PsA (for CC versus GG, odds ratio 1.65, 95% confidence interval 1.13-2.41, uncorrected P = 0.005).0.0026384742005SLC22A5;LOC5531035132369766CG
rs3212227232970153593IL12Bumls:C0003872BeFreeMeta-analysis of IL12B polymorphisms (rs3212227, rs6887695) with psoriasis and psoriatic arthritis.0.1351783392012IL12B5159315942TG
rs3212227188001483593IL12Bumls:C0003872BeFreeFor both PA and PV, we detected the strongest association with two IL12B single-nucleotide polymorphisms and the corresponding haplotype as reflected by minimal P-values of 10(-7) and highest odds ratios of 1.50 (1.28-1.75) for rs6887695 in PA patients and 1.50 (1.27-1.76) for rs3212227 in the PV cohort, respectively.0.1351783392009IL12B5159315942TG
rs339805002095318810758TRAF3IP2umls:C0003872BeFreeA stratified analysis of our datasets including only PsA cases (1,922 cases compared to 8,037 controls, P = 4.57 × 10⁻¹² for rs33980500) suggested that TRAF3IP2 represents a shared susceptibility for PsV and PsA.0.2466341572010TRAF3IP2;TRAF3IP2-AS16111592059CT
rs3398050020953186643749TRAF3IP2-AS1umls:C0003872GWASCATCommon variants at TRAF3IP2 are associated with susceptibility to psoriatic arthritis and psoriasis.0.122010TRAF3IP2;TRAF3IP2-AS16111592059CT
rs339805002095318610758TRAF3IP2umls:C0003872GWASCATCommon variants at TRAF3IP2 are associated with susceptibility to psoriatic arthritis and psoriasis.0.2466341572010TRAF3IP2;TRAF3IP2-AS16111592059CT
rs339805002095318610758TRAF3IP2umls:C0003872GAD[Common variants at TRAF3IP2 are associated with susceptibility to psoriatic arthritis and psoriasis.]0.2466341572010TRAF3IP2;TRAF3IP2-AS16111592059CT
rs4535211223287386775STAT4umls:C0003872BeFreeSignificant evidence for association with susceptibility to PsA was found toa SNP mapping to the REL (rs13017599, p(trend)=5.2×10(4)) gene, while nominal evidence for association (p(trend)<0.05) was found to seven other loci including PLCL2 (rs4535211, p=1.7×10(-3)); STAT4 (rs10181656, p=3.0×10(-3)) and the AFF3, CD28, CCL21, IL2 and KIF5A loci.0.0002714422012PLCL2317031505AG
rs4535211223287383798KIF5Aumls:C0003872BeFreeSignificant evidence for association with susceptibility to PsA was found toa SNP mapping to the REL (rs13017599, p(trend)=5.2×10(4)) gene, while nominal evidence for association (p(trend)<0.05) was found to seven other loci including PLCL2 (rs4535211, p=1.7×10(-3)); STAT4 (rs10181656, p=3.0×10(-3)) and the AFF3, CD28, CCL21, IL2 and KIF5A loci.0.0002714422012PLCL2317031505AG
rs4535211223287383899AFF3umls:C0003872BeFreeSignificant evidence for association with susceptibility to PsA was found toa SNP mapping to the REL (rs13017599, p(trend)=5.2×10(4)) gene, while nominal evidence for association (p(trend)<0.05) was found to seven other loci including PLCL2 (rs4535211, p=1.7×10(-3)); STAT4 (rs10181656, p=3.0×10(-3)) and the AFF3, CD28, CCL21, IL2 and KIF5A loci.0.0005428842012PLCL2317031505AG
rs4535211223287386366CCL21umls:C0003872BeFreeSignificant evidence for association with susceptibility to PsA was found toa SNP mapping to the REL (rs13017599, p(trend)=5.2×10(4)) gene, while nominal evidence for association (p(trend)<0.05) was found to seven other loci including PLCL2 (rs4535211, p=1.7×10(-3)); STAT4 (rs10181656, p=3.0×10(-3)) and the AFF3, CD28, CCL21, IL2 and KIF5A loci.0.0002714422012PLCL2317031505AG
rs45352112232873823228PLCL2umls:C0003872BeFreeSignificant evidence for association with susceptibility to PsA was found toa SNP mapping to the REL (rs13017599, p(trend)=5.2×10(4)) gene, while nominal evidence for association (p(trend)<0.05) was found to seven other loci including PLCL2 (rs4535211, p=1.7×10(-3)); STAT4 (rs10181656, p=3.0×10(-3)) and the AFF3, CD28, CCL21, IL2 and KIF5A loci.0.0002714422012PLCL2317031505AG
rs4535211223287383558IL2umls:C0003872BeFreeSignificant evidence for association with susceptibility to PsA was found toa SNP mapping to the REL (rs13017599, p(trend)=5.2×10(4)) gene, while nominal evidence for association (p(trend)<0.05) was found to seven other loci including PLCL2 (rs4535211, p=1.7×10(-3)); STAT4 (rs10181656, p=3.0×10(-3)) and the AFF3, CD28, CCL21, IL2 and KIF5A loci.0.0005428842012PLCL2317031505AG
rs453521122328738940CD28umls:C0003872BeFreeSignificant evidence for association with susceptibility to PsA was found toa SNP mapping to the REL (rs13017599, p(trend)=5.2×10(4)) gene, while nominal evidence for association (p(trend)<0.05) was found to seven other loci including PLCL2 (rs4535211, p=1.7×10(-3)); STAT4 (rs10181656, p=3.0×10(-3)) and the AFF3, CD28, CCL21, IL2 and KIF5A loci.0.0002714422012PLCL2317031505AG
rs6887695232970153593IL12Bumls:C0003872BeFreeMeta-analysis of IL12B polymorphisms (rs3212227, rs6887695) with psoriasis and psoriatic arthritis.0.1351783392012NA5159395637GC
rs6887695188001483593IL12Bumls:C0003872BeFreeFor both PA and PV, we detected the strongest association with two IL12B single-nucleotide polymorphisms and the corresponding haplotype as reflected by minimal P-values of 10(-7) and highest odds ratios of 1.50 (1.28-1.75) for rs6887695 in PA patients and 1.50 (1.27-1.76) for rs3212227 in the PV cohort, respectively.0.1351783392009NA5159395637GC
rs70287322170493400957LINC01185umls:C0003872GWASCATGenome-wide meta-analysis of psoriatic arthritis identifies susceptibility locus at REL.0.122012LINC01185260854407CT
GWASdb Annotation(Total Genotypes:0)
(Waiting for update.)
GWASdb Snp Trait(Total Genotypes:5)
CHR POS SNPID REF ALT ORI_SNPID PMID P_VALUE P_VALUE_TEXT OR/BETA CI95_TEXT GWAS_INITIAL_SAMPLE_SIZE SUB_POPULATION SUPER_POPULATION GWAS_TRAIT HPO_ID HPO_TERM DO_ID DO_TERM MESH_ID MESH_TERM EFO_ID EFO_TERM DOLITE_TERM RISK_ALLELE PUBLICATION_TYPE AA GENE_SYMBOL TYPE REFGENE
261081542rs702873CTrs702873221704932.00E-07NA1.2[1.13-1.28] 535 European ancestry cases; 3,432 European ancestry controlsEuropean(3967)ALL(3967)EUR(3967)ALL(3967)Psoriatic arthritisHPOID:0003765HPOID:0001369PsoriasisArthritisDOID:9008psoriatic arthritisD015535Arthritis, PsoriaticEFOID:0003778psoriatic arthritisPsoriasisArthritisNA
261164331rs13017599GArs13017599221704931.00E-08NA1.27[1.18-1.35] 535 European ancestry cases; 3,432 European ancestry controlsEuropean(3967)ALL(3967)EUR(3967)ALL(3967)Psoriatic arthritisHPOID:0003765HPOID:0001369PsoriasisArthritisDOID:9008psoriatic arthritisD015535Arthritis, PsoriaticEFOID:0003778psoriatic arthritisPsoriasisArthritisNA
5158829527rs12188300ATrs12188300209531867.00E-17NA1.7[1.50-1.93]572 German cases; 888 German controlsGerman(1460)ALL(1460)EUR(1460)ALL(1460)Psoriatic arthritisHPOID:0003765HPOID:0001369PsoriasisArthritisDOID:9008psoriatic arthritisD015535Arthritis, PsoriaticEFOID:0003778psoriatic arthritisPsoriasisArthritisrs12188300-T
631241109rs13191343CTrs13191343209531862.00E-72NA2.37[2.16-2.61]572 German cases; 888 German controlsGerman(1460)ALL(1460)EUR(1460)ALL(1460)Psoriatic arthritisHPOID:0003765HPOID:0001369PsoriasisArthritisDOID:9008psoriatic arthritisD015535Arthritis, PsoriaticEFOID:0003778psoriatic arthritisPsoriasisArthritisrs13191343-T
6111913262rs33980500CTrs33980500209531861.00E-20NA1.95[1.69-2.24]572 German cases; 888 German controlsGerman(1460)ALL(1460)EUR(1460)ALL(1460)Psoriatic arthritisHPOID:0003765HPOID:0001369PsoriasisArthritisDOID:9008psoriatic arthritisD015535Arthritis, PsoriaticEFOID:0003778psoriatic arthritisPsoriasisArthritisrs33980500-T
Mapped by lexical matching(Total Items:0)
(Waiting for update.)
Mapped by homologous gene(Total Items:0)
(Waiting for update.)
Chemical(Total Drugs:5)
CUI ChemicalName ChemicalID CasRN DiseaseName DiseaseID DirectEvidence PubMedIDs
C0003872acitretinD01725555079-83-9arthritis, psoriaticMESH:D015535therapeutic14746632
C0003872colchicineD00307864-86-8arthritis, psoriaticMESH:D015535therapeutic17408446
C0003872diclofenacD00400815307-86-5arthritis, psoriaticMESH:D015535therapeutic7487376
C0003872folic acidD00549259-30-3arthritis, psoriaticMESH:D015535therapeutic17190135
C0003872methotrexateD0087271959/5/2arthritis, psoriaticMESH:D015535therapeutic11771523
FDA approved drug and dosage information(Total Drugs:0)
(Waiting for update.)
FDA labeling changes(Total Drugs:0)
(Waiting for update.)