PedAM

Pediatric Disease Annotations & Medicines


	protein-losing enteropathies

Disease ID	1003
Disease	protein-losing enteropathies
Definition	Pathological conditions in the INTESTINES that are characterized by the gastrointestinal loss of serum proteins, including SERUM ALBUMIN; IMMUNOGLOBULINS; and at times LYMPHOCYTES. Severe condition can result in HYPOGAMMAGLOBULINEMIA or LYMPHOPENIA. Protein-losing enteropathies are associated with a number of diseases including INTESTINAL LYMPHANGIECTASIS; WHIPPLE'S DISEASE; and NEOPLASMS of the SMALL INTESTINE.
Synonym	enteropathies, exudative enteropathies, protein-losing enteropathy protein losing enteropathy, exudative enteropathy, protein losing enteropathy, protein-losing exudative enteropathies exudative enteropathy exudative enteropathy (disorder) ple ple - protein-losing enteropathy protein losing enteropathies protein losing enteropathy protein-losing enteropathies [disease/finding] protein-losing enteropathy protein-losing enteropathy (disorder)
OMIM	OMIM:226300
DOID	DOID:10611
UMLS	C0033680
MeSH	D011504
SNOMED-CT	SNOMEDCT_US_2016_09_01:22542007;SNOMEDCT_US_2016_09_01:66972006
Comorbidity	UMLS \| Disease \| Sentences' Count(Total Sentences:40) C0024214 \| lymphangiectasia \| 5 C0409974 \| lupus erythematosus \| 3 C0009319 \| colitis \| 3 C0238067 \| collagenous colitis \| 3 C0024312 \| lymphopenia \| 3 C0011991 \| diarrhea \| 3 C0009782 \| connective tissue disease \| 2 C0024141 \| systemic lupus erythematosus \| 2 C0042961 \| volvulus \| 1 C0026272 \| mixed connective tissue disease \| 1 C0023448 \| lymphoblastic leukemia \| 1 C0006897 \| capillariasis \| 1 C0343363 \| rotavirus gastroenteritis \| 1 C0034150 \| purpura \| 1 C0398623 \| hypercoagulability \| 1 C0278805 \| lymphoma of the small bowel \| 1 C0017178 \| gastrointestinal disorders \| 1 C0162429 \| malnutrition \| 1 C0345893 \| juvenile polyposis \| 1 C0024523 \| malabsorption \| 1 C0024299 \| lymphoma \| 1 C0242647 \| malt lymphoma \| 1 C0345893 \| juvenile polyposis syndrome \| 1 C0042373 \| vascular disease \| 1 C0031048 \| constrictive pericarditis \| 1 C0017178 \| gastrointestinal disorder \| 1 C0031046 \| pericarditis \| 1 C0017536 \| giardiasis \| 1 C0034152 \| henoch-schonlein purpura \| 1 C0017536 \| intestinal giardiasis \| 1 C0042373 \| vascular diseases \| 1 C0282207 \| cronkhite-canada syndrome \| 1 C0023418 \| leukemia \| 1 C0023449 \| acute lymphoblastic leukemia \| 1 C0007642 \| cellulitis \| 1 C1261473 \| sarcoma \| 1 C0262428 \| collagen vascular disease \| 1 C0036220 \| kaposi sarcoma \| 1 C0017160 \| gastroenteritis \| 1 C0018799 \| cardiac disease \| 1
Curated Gene	Entrez_id \| Symbol \| Resource(Total Genes:1) MC1R \| 4157 \| CTD_human
Inferring Gene	(Waiting for update.)
Text Mined Gene	Entrez_id \| Symbol \| Score \| Resource(Total Genes:57) 3691 \| ITGB4 \| DISEASES 6948 \| TCN2 \| DISEASES 973 \| CD79A \| DISEASES 657 \| BMPR1A \| DISEASES 84649 \| DGAT2 \| DISEASES 7276 \| TTR \| DISEASES 83483 \| PLVAP \| DISEASES 6382 \| SDC1 \| DISEASES 1401 \| CRP \| DISEASES 2581 \| GALC \| DISEASES 114294 \| LACTB \| DISEASES 2201 \| FBN2 \| DISEASES 3682 \| ITGAE \| DISEASES 644 \| BLVRA \| DISEASES 2627 \| GATA6 \| DISEASES 5741 \| PTH \| DISEASES 10225 \| CD96 \| DISEASES 5205 \| ATP8B1 \| DISEASES 9073 \| CLDN8 \| DISEASES 7547 \| ZIC3 \| DISEASES 6750 \| SST \| DISEASES 213 \| ALB \| DISEASES 79053 \| ALG8 \| DISEASES 91949 \| COG7 \| DISEASES 118429 \| ANTXR2 \| DISEASES 2147 \| F2 \| DISEASES 6578 \| SLCO2A1 \| DISEASES 924 \| CD7 \| DISEASES 2629 \| GBA \| DISEASES 4351 \| MPI \| DISEASES 5339 \| PLEC \| DISEASES 23545 \| ATP6V0A2 \| DISEASES 8694 \| DGAT1 \| DISEASES 3266 \| ERAS \| DISEASES 1811 \| SLC26A3 \| DISEASES 5265 \| SERPINA1 \| DISEASES 8794 \| TNFRSF10C \| DISEASES 916 \| CD3E \| DISEASES 28514 \| DLL1 \| DISEASES 7044 \| LEFTY2 \| DISEASES 5321 \| PLA2G4A \| DISEASES 462 \| SERPINC1 \| DISEASES 6283 \| S100A12 \| DISEASES 959 \| CD40LG \| DISEASES 29929 \| ALG6 \| DISEASES 229 \| ALDOB \| DISEASES 795 \| S100G \| DISEASES 10203 \| CALCRL \| DISEASES 2172 \| FABP6 \| DISEASES 5660 \| PSAP \| DISEASES 7018 \| TF \| DISEASES 3655 \| ITGA6 \| DISEASES 10216 \| PRG4 \| DISEASES 147372 \| CCBE1 \| DISEASES 111 \| ADCY5 \| DISEASES 2053 \| EPHX2 \| DISEASES 344 \| APOC2 \| DISEASES
Locus	(Waiting for update.)

Disease ID	1003
Disease	protein-losing enteropathies
Integrated Phenotype	HPO \| Name(Total Integrated Phenotypes:10) HP:0001510 \| Growth deficiency HP:0000969 \| Dropsy HP:0002242 \| Enteropathy HP:0003075 \| Hypoproteinemia HP:0002014 \| Diarrhea HP:0001541 \| Ascites HP:0002027 \| Abdominal pain HP:0002639 \| Budd-Chiari syndrome HP:0001891 \| Iron-deficiency anemia HP:0001217 \| Digital clubbing
Text Mined Phenotype	HPO \| Name \| Sentences' Count(Total Phenotypes:29) HP:0003073 \| Hypoalbuminaemia \| 5 HP:0002014 \| Diarrhea \| 3 HP:0002583 \| Colitis \| 3 HP:0002593 \| Intestinal lymphangiectasia \| 3 HP:0001888 \| Lymphocytopenia \| 3 HP:0003075 \| Hypoproteinemia \| 2 HP:0002725 \| Systemic lupus erythematosus \| 2 HP:0000969 \| Dropsy \| 2 HP:0001701 \| Pericarditis \| 1 HP:0002665 \| Lymphoma \| 1 HP:0100724 \| Hypercoagulability \| 1 HP:0001909 \| Leukemia \| 1 HP:0006721 \| Acute lymphocytic leukemia \| 1 HP:0004395 \| Malnutrition \| 1 HP:0002239 \| Gastrointestinal hemorrhage \| 1 HP:0004313 \| Decreased immunoglobulin level \| 1 HP:0100242 \| Sarcoma \| 1 HP:0000979 \| Purpura \| 1 HP:0004387 \| Enterocolitis \| 1 HP:0002580 \| Volvulus \| 1 HP:0002584 \| Intestinal hemorrhage \| 1 HP:0001945 \| Fever \| 1 HP:0001508 \| Weight faltering \| 1 HP:0002563 \| Constrictive pericarditis \| 1 HP:0100658 \| Bacterial infection of skin \| 1 HP:0002716 \| Lymph node hyperplasia \| 1 HP:0002024 \| Intestinal malabsorption \| 1 HP:0010741 \| Peripheral edema of lower extremity \| 1 HP:0012593 \| Nephrotic range proteinuria \| 1

Disease ID	1003
Disease	protein-losing enteropathies
Manually Symptom	(Waiting for update.)
Text Mined Symptom	UMLS \| Name \| Sentences' Count(Total Symptoms:6) C0024312 \| lymphopenia \| 2 C0238067 \| collagenous colitis \| 2 C0024215 \| intestinal lymphangiectasia \| 2 C0020639 \| hypoproteinemia \| 2 C0011991 \| diarrhea \| 1 C0282207 \| cronkhite-canada syndrome \| 1

Manually Genotype(Total Text Mining Genotypes:0)
(Waiting for update.)

All Snps(Total Genotypes:0)
(Waiting for update.)

GWASdb Annotation(Total Genotypes:0)
(Waiting for update.)

GWASdb Snp Trait(Total Genotypes:0)
(Waiting for update.)

Mapped by lexical matching(Total Items:0)
(Waiting for update.)

Mapped by homologous gene(Total Items:0)
(Waiting for update.)

Chemical(Total Drugs:0)
(Waiting for update.)

FDA approved drug and dosage information(Total Drugs:0)
(Waiting for update.)

FDA labeling changes(Total Drugs:0)
(Waiting for update.)

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