PedAM

Pediatric Disease Annotations & Medicines


	primary central nervous system lymphoma

Disease ID	938
Disease	primary central nervous system lymphoma
Definition	A form of extranodal, high-grade non-Hodgkin B-cell neoplasm, usually large cell or immunoblastic type that originates in the brain, leptomeninges, spinal cord, or eyes and typically remains confined to the CNS. [pmid:23696924]
Synonym	[m]microglioma [m]microglioma (morphologic abnormality) central nervous system lymphoma, primary cns lymphoma primary cns lymphoma, primary lymphoma, primary central nervous system lymphoma, primary cns microglioma microglioma (disorder) microglioma (morphologic abnormality) microglioma -retired- microglioma [obs] pcnsl pcnsl - primary cns lymphoma primary cns lymphoma primary lymphoma cns
Orphanet	ORPHANET:46135
DOID	DOID:3234
UMLS	C0280803
SNOMED-CT	SNOMEDCT_US_2016_09_01:307649006
Comorbidity	UMLS \| Disease \| Sentences' Count(Total Sentences:21) C0409974 \| lupus erythematosus \| 1 C0007688 \| central retinal artery occlusion \| 1 C0281658 \| intraocular lymphoma \| 1 C0017636 \| glioblastoma \| 1 C0001175 \| acquired immune deficiency \| 1 C0023493 \| adult t-cell leukemia \| 1 C0023492 \| t-cell leukemia \| 1 C0023418 \| leukemia \| 1 C0003873 \| rheumatoid arthritis \| 1 C0035302 \| retinal artery occlusion \| 1 C0024299 \| lymphoma \| 1 C0497327 \| dementia \| 1 C0011847 \| diabetes \| 1 C0001175 \| acquired immune deficiency syndrome \| 1 C0024141 \| systemic lupus erythematosus \| 1 C0024299 \| lymphomas \| 1 C0730306 \| ocular lymphoma \| 1 C0281658 \| primary intraocular lymphoma \| 1 C1621958 \| glioblastoma multiforme \| 1 C0011848 \| diabetes insipidus \| 1 C0003864 \| arthritis \| 1
Curated Gene	(Waiting for update.)
Inferring Gene	(Waiting for update.)
Text Mined Gene	(Waiting for update.)
Locus	(Waiting for update.)

Disease ID	938
Disease	primary central nervous system lymphoma
Integrated Phenotype	(Waiting for update.)
Text Mined Phenotype	HPO \| Name \| Sentences' Count(Total Phenotypes:12) HP:0002721 \| Immunodeficiency \| 2 HP:0100843 \| Glioblastoma \| 1 HP:0002725 \| Systemic lupus erythematosus \| 1 HP:0002665 \| Lymphoma \| 1 HP:0001370 \| Rheumatoid arthritis \| 1 HP:0000873 \| Diabetes insipidus \| 1 HP:0012174 \| Glioblastoma multiforme \| 1 HP:0001369 \| Arthritis \| 1 HP:0001909 \| Leukemia \| 1 HP:0002902 \| Hyponatremia \| 1 HP:0002664 \| Neoplasia \| 1 HP:0000726 \| Dementia \| 1

Disease ID	938
Disease	primary central nervous system lymphoma
Manually Symptom	UMLS \| Name(Total Manually Symptoms:6) C1704231 \| lymphomatous meningitis C0751297 \| leptomeningeal tumor C0748903 \| spinal cord involvement C0339556 \| retinal lymphoma C0149678 \| epstein-barr virus infection C0024141 \| systemic lupus
Text Mined Symptom	UMLS \| Name \| Sentences' Count(Total Symptoms:1) C0024141 \| systemic lupus \| 1

Manually Genotype(Total Text Mining Genotypes:0)
(Waiting for update.)

All Snps(Total Genotypes:2)
snpId	pubmedId	geneId	geneSymbol	diseaseId	sourceId	sentence	score	Year	geneSymbol_dbSNP	CHROMOSOME	POS	REF	ALT
rs1801131	20237949	4524	MTHFR	umls:C0280803	BeFree	Furthermore, for the methylenetetrahydrofolate reductase (MTHFR) c.1298A > C (E429A) polymorphism the mutated C-allele was found more frequently among PCNSL patients than among population controls (P = 0.026; OR = 1.57; 1.05-2.34).	0.000271442	2010	MTHFR	1	11794419	T	G
rs1805087	15138479	4548	MTR	umls:C0280803	BeFree	The methionine synthase polymorphism D919G alters susceptibility to primary central nervous system lymphoma.	0.000271442	2004	MTR	1	236885200	A	G

GWASdb Annotation(Total Genotypes:0)
(Waiting for update.)

GWASdb Snp Trait(Total Genotypes:0)
(Waiting for update.)

Mapped by lexical matching(Total Items:0)
(Waiting for update.)

Mapped by homologous gene(Total Items:0)
(Waiting for update.)

Chemical(Total Drugs:0)
(Waiting for update.)

FDA approved drug and dosage information(Total Drugs:0)
(Waiting for update.)

FDA labeling changes(Total Drugs:0)
(Waiting for update.)

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