PedAM

Pediatric Disease Annotations & Medicines


	portal hypertension

Disease ID	327
Disease	portal hypertension
Definition	Abnormal increase of resistance to blood flow within the hepatic PORTAL SYSTEM, frequently seen in LIVER CIRRHOSIS and conditions with obstruction of the PORTAL VEIN.
Synonym	hypertension portal hypertension, portal hypertension, portal [disease/finding] hypertensions, portal pht - portal hypertension portal hypertension (disorder) portal hypertensions
DOID	DOID:10762
ICD10	ICD10CM:K76.6
UMLS	C0020541
MeSH	D006975
SNOMED-CT	SNOMEDCT_US_2016_09_01:34742003
Comorbidity	UMLS \| Disease \| Sentences' Count(Total Sentences:121) C0023890 \| cirrhosis \| 166 C0042345 \| varices \| 71 C0023890 \| liver cirrhosis \| 62 C0023895 \| liver disease \| 47 C0014867 \| esophageal varices \| 35 C0020532 \| hypersplenism \| 18 C0040053 \| thrombosis \| 14 C1619734 \| pulmonary arterial hypertension \| 12 C0014867 \| oesophageal varices \| 12 C0036323 \| schistosomiasis \| 11 C0023895 \| liver diseases \| 11 C0155773 \| portal vein thrombosis \| 10 C0020538 \| hypertension \| 8 C0019204 \| hepatocellular carcinoma \| 7 C0005411 \| biliary atresia \| 7 C0023890 \| hepatic cirrhosis \| 6 C0040034 \| thrombocytopenia \| 6 C0023891 \| alcoholic cirrhosis \| 6 C0019196 \| hepatitis c \| 5 C0008312 \| biliary cirrhosis \| 4 C0002871 \| anemia \| 4 C0030305 \| pancreatitis \| 4 C0036202 \| sarcoidosis \| 3 C0019158 \| hepatitis \| 3 C1260402 \| splenic sequestration \| 3 C0023895 \| hepatic disease \| 3 C0020542 \| pulmonary hypertension \| 3 C0155747 \| splenic artery aneurysm \| 3 C0024623 \| gastric cancer \| 3 C0001815 \| myelofibrosis \| 3 C0600452 \| hepatopulmonary syndrome \| 2 C0085413 \| autosomal dominant polycystic kidney \| 2 C0023418 \| leukemia \| 2 C0008340 \| choledochal cyst \| 2 C0085413 \| autosomal dominant polycystic kidney disease \| 2 C0018920 \| cavernoma \| 2 C0029454 \| osteopetrosis \| 2 C0030312 \| pancytopenia \| 2 C0019212 \| hepatorenal syndrome \| 2 C0023890 \| cirrhosis of liver \| 2 C0019151 \| hepatic encephalopathy \| 2 C0014848 \| achalasia \| 1 C0021390 \| inflammatory bowel disease \| 1 C0030781 \| peliosis hepatis \| 1 C1333977 \| hepatitis b virus-related hepatocellular carcinoma \| 1 C0013502 \| hydatid cyst \| 1 C0001815 \| idiopathic myelofibrosis \| 1 C1112746 \| hepatic lymphoma \| 1 C0494165 \| liver metastases \| 1 C0017658 \| glomerulonephritis \| 1 C0009782 \| connective tissue disease \| 1 C0241910 \| autoimmune hepatitis \| 1 C0002878 \| hemolytic anemia \| 1 C0085404 \| poems syndrome \| 1 C0042345 \| varicose veins \| 1 C0027947 \| neutropenia \| 1 C0023487 \| promyelocytic leukemia \| 1 C0019163 \| hepatitis b \| 1 C0023487 \| acute promyelocytic leukemia \| 1 C0021831 \| enteropathy \| 1 C0023470 \| myelocytic leukemia \| 1 C0023281 \| leishmaniasis \| 1 C0042345 \| varicosities \| 1 C0009402 \| colorectal cancer \| 1 C0023891 \| alcoholic liver cirrhosis \| 1 C0042373 \| vascular disorders \| 1 C0042373 \| vascular disease \| 1 C0024523 \| malabsorption \| 1 C0010674 \| cystic fibrosis \| 1 C0009319 \| colitis \| 1 C0024899 \| mastocytosis \| 1 C0023290 \| visceral leishmaniasis \| 1 C0003615 \| appendicitis \| 1 C0206754 \| neuroendocrine tumors \| 1 C0017205 \| gaucher's disease \| 1 C0007570 \| coeliac disease \| 1 C0007113 \| rectal cancer \| 1 C0002726 \| amyloidosis \| 1 C0221013 \| systemic mastocytosis \| 1 C0024299 \| lymphoma \| 1 C0036631 \| seminomas \| 1 C0019154 \| hepatic vein thrombosis \| 1 C0023895 \| hepatocellular disease \| 1 C0030286 \| pancreatic disease \| 1 C0008325 \| cholecystitis \| 1 C0018801 \| heart failure \| 1 C0162529 \| ischemic colitis \| 1 C0008311 \| cholangitis \| 1 C0019151 \| portosystemic encephalopathy \| 1 C0024314 \| lymphoproliferative disorders \| 1 C0018916 \| hemangioma \| 1 C0018920 \| cavernous hemangioma \| 1 C0019187 \| alcoholic hepatitis \| 1 C0039445 \| hereditary hemorrhagic telangiectasia \| 1 C0042345 \| varicose vein \| 1 C0040147 \| thyroiditis \| 1 C0019322 \| umbilical hernia \| 1 C0162510 \| caroli disease \| 1 C0034150 \| peliosis \| 1 C0036319 \| schistosoma mansoni \| 1 C0677607 \| hashimoto's thyroiditis \| 1 C0085669 \| acute leukemia \| 1 C0027708 \| wilms' tumor \| 1 C0026272 \| mixed connective tissue disease \| 1 C0024314 \| lymphoproliferative disorder \| 1 C0162316 \| iron deficiency anemia \| 1 C0699791 \| gastric carcinoma \| 1 C0019158 \| inflammatory liver disease \| 1 C0017152 \| gastritis \| 1 C0206754 \| neuroendocrine tumor \| 1 C0021831 \| bowel disease \| 1 C0149521 \| chronic pancreatitis \| 1 C0001430 \| adenoma \| 1 C0027022 \| myeloproliferative neoplasms \| 1 C0030286 \| pancreatic diseases \| 1 C0265965 \| dyskeratosis congenita \| 1 C0162429 \| poor nutrition \| 1 C0031154 \| peritonitis \| 1 C0007570 \| celiac disease \| 1 C0042373 \| vascular disorder \| 1 C0007222 \| cardiovascular disorders \| 1
Curated Gene	Entrez_id \| Symbol \| Resource(Total Genes:3) AVP \| 551 \| CTD_human NOS3 \| 4846 \| CTD_human VEGFA \| 7422 \| CTD_human
Inferring Gene	(Waiting for update.)
Text Mined Gene	Entrez_id \| Symbol \| Score \| Resource(Total Genes:239) 282706 \| DAOA-AS1 \| DISEASES 1080 \| CFTR \| DISEASES 79657 \| RPAP3 \| DISEASES 10911 \| UTS2 \| DISEASES 84957 \| RELT \| DISEASES 2249 \| FGF4 \| DISEASES 7066 \| THPO \| DISEASES 25984 \| KRT23 \| DISEASES 3162 \| HMOX1 \| DISEASES 5834 \| PYGB \| DISEASES 3929 \| LBP \| DISEASES 27344 \| PCSK1N \| DISEASES 7076 \| TIMP1 \| DISEASES 479 \| ATP12A \| DISEASES 4313 \| MMP2 \| DISEASES 58189 \| WFDC1 \| DISEASES 3163 \| HMOX2 \| DISEASES 51285 \| RASL12 \| DISEASES 1512 \| CTSH \| DISEASES 4051 \| CYP4F3 \| DISEASES 2091 \| FBL \| DISEASES 7040 \| TGFB1 \| DISEASES 973 \| CD79A \| DISEASES 9545 \| RAB3D \| DISEASES 3082 \| HGF \| DISEASES 5054 \| SERPINE1 \| DISEASES 55163 \| PNPO \| DISEASES 1277 \| COL1A1 \| DISEASES 1610 \| DAO \| DISEASES 64895 \| PAPOLG \| DISEASES 4852 \| NPY \| DISEASES 64105 \| CENPK \| DISEASES 1948 \| EFNB2 \| DISEASES 56914 \| OTOR \| DISEASES 6945 \| MLX \| DISEASES 10365 \| KLF2 \| DISEASES 2678 \| GGT1 \| DISEASES 54567 \| DLL4 \| DISEASES 3630 \| INS \| DISEASES 2006 \| ELN \| DISEASES 5589 \| PRKCSH \| DISEASES 59272 \| ACE2 \| DISEASES 1571 \| CYP2E1 \| DISEASES 10343 \| PKDREJ \| DISEASES 2161 \| F12 \| DISEASES 8431 \| NR0B2 \| DISEASES 23225 \| NUP210 \| DISEASES 5791 \| PTPRE \| DISEASES 1401 \| CRP \| DISEASES 187 \| APLNR \| DISEASES 3569 \| IL6 \| DISEASES 9394 \| HS6ST1 \| DISEASES 255488 \| RNF144B \| DISEASES 4659 \| PPP1R12A \| DISEASES 7450 \| VWF \| DISEASES 4223 \| MEOX2 \| DISEASES 6521 \| SLC4A1 \| DISEASES 495 \| ATP4A \| DISEASES 7077 \| TIMP2 \| DISEASES 2549 \| GAB1 \| DISEASES 3553 \| IL1B \| DISEASES 8726 \| EED \| DISEASES 6403 \| SELP \| DISEASES 8647 \| ABCB11 \| DISEASES 3791 \| KDR \| DISEASES 57514 \| ARHGAP31 \| DISEASES 590 \| BCHE \| DISEASES 80725 \| SRCIN1 \| DISEASES 2162 \| F13A1 \| DISEASES 3827 \| KNG1 \| DISEASES 80315 \| CPEB4 \| DISEASES 5244 \| ABCB4 \| DISEASES 409 \| ARRB2 \| DISEASES 432 \| ASGR1 \| DISEASES 207 \| AKT1 \| DISEASES 2702 \| GJA5 \| DISEASES 5972 \| REN \| DISEASES 185 \| AGTR1 \| DISEASES 167410 \| LIX1 \| DISEASES 2041 \| EPHA1 \| DISEASES 3439 \| IFNA1 \| DISEASES 133 \| ADM \| DISEASES 1360 \| CPB1 \| DISEASES 5205 \| ATP8B1 \| DISEASES 23576 \| DDAH1 \| DISEASES 2776 \| GNAQ \| DISEASES 6750 \| SST \| DISEASES 1636 \| ACE \| DISEASES 5739 \| PTGIR \| DISEASES 5152 \| PDE9A \| DISEASES 57572 \| DOCK6 \| DISEASES 4880 \| NPPC \| DISEASES 285203 \| EOGT \| DISEASES 213 \| ALB \| DISEASES 54859 \| ELP6 \| DISEASES 327 \| APEH \| DISEASES 116379 \| IL22RA2 \| DISEASES 4846 \| NOS3 \| DISEASES 203286 \| ANKS6 \| DISEASES 8642 \| DCHS1 \| DISEASES 94274 \| PPP1R14A \| DISEASES 3479 \| IGF1 \| DISEASES 59350 \| RXFP1 \| DISEASES 8862 \| APLN \| DISEASES 2353 \| FOS \| DISEASES 4968 \| OGG1 \| DISEASES 6373 \| CXCL11 \| DISEASES 9451 \| EIF2AK3 \| DISEASES 2147 \| F2 \| DISEASES 5340 \| PLG \| DISEASES 6868 \| ADAM17 \| DISEASES 947 \| CD34 \| DISEASES 27257 \| LSM1 \| DISEASES 358 \| AQP1 \| DISEASES 118430 \| MUCL1 \| DISEASES 80169 \| CTC1 \| DISEASES 1909 \| EDNRA \| DISEASES 9475 \| ROCK2 \| DISEASES 6014 \| RIT2 \| DISEASES 3039 \| HBA1 \| DISEASES 8706 \| B3GALNT1 \| DISEASES 2837 \| UTS2R \| DISEASES 9622 \| KLK4 \| DISEASES 117584 \| RFFL \| DISEASES 4843 \| NOS2 \| DISEASES 147719 \| LYPD4 \| DISEASES 286826 \| LIN9 \| DISEASES 286753 \| TUSC5 \| DISEASES 527 \| ATP6V0C \| DISEASES 7490 \| WT1 \| DISEASES 2520 \| GAST \| DISEASES 6297 \| SALL2 \| DISEASES 2152 \| F3 \| DISEASES 3320 \| HSP90AA1 \| DISEASES 957 \| ENTPD5 \| DISEASES 10957 \| PNRC1 \| DISEASES 1908 \| EDN3 \| DISEASES 3988 \| LIPA \| DISEASES 4842 \| NOS1 \| DISEASES 3363 \| HTR7 \| DISEASES 3266 \| ERAS \| DISEASES 857 \| CAV1 \| DISEASES 4128 \| MAOA \| DISEASES 10164 \| CHST4 \| DISEASES 6672 \| SP100 \| DISEASES 2701 \| GJA4 \| DISEASES 8654 \| PDE5A \| DISEASES 5265 \| SERPINA1 \| DISEASES 84458 \| LCOR \| DISEASES 6288 \| SAA1 \| DISEASES 6752 \| SSTR2 \| DISEASES 2050 \| EPHB4 \| DISEASES 1969 \| EPHA2 \| DISEASES 9583 \| ENTPD4 \| DISEASES 9332 \| CD163 \| DISEASES 4478 \| MSN \| DISEASES 26580 \| BSCL2 \| DISEASES 5742 \| PTGS1 \| DISEASES 4283 \| CXCL9 \| DISEASES 5321 \| PLA2G4A \| DISEASES 5743 \| PTGS2 \| DISEASES 462 \| SERPINC1 \| DISEASES 1490 \| CTGF \| DISEASES 55974 \| SLC50A1 \| DISEASES 85413 \| SLC22A16 \| DISEASES 1268 \| CNR1 \| DISEASES 959 \| CD40LG \| DISEASES 7803 \| PTP4A1 \| DISEASES 1491 \| CTH \| DISEASES 79819 \| WDR78 \| DISEASES 5314 \| PKHD1 \| DISEASES 5950 \| RBP4 \| DISEASES 8813 \| DPM1 \| DISEASES 11253 \| MAN1B1 \| DISEASES 11093 \| ADAMTS13 \| DISEASES 7422 \| VEGFA \| DISEASES 4318 \| MMP9 \| DISEASES 4352 \| MPL \| DISEASES 1025 \| CDK9 \| DISEASES 84890 \| ADO \| DISEASES 659 \| BMPR2 \| DISEASES 2155 \| F7 \| DISEASES 57819 \| LSM2 \| DISEASES 23564 \| DDAH2 \| DISEASES 3055 \| HCK \| DISEASES 4524 \| MTHFR \| DISEASES 7056 \| THBD \| DISEASES 1910 \| EDNRB \| DISEASES 3274 \| HRH2 \| DISEASES 64344 \| HIF3A \| DISEASES 688 \| KLF5 \| DISEASES 1906 \| EDN1 \| DISEASES 3096 \| HIVEP1 \| DISEASES 3704 \| ITPA \| DISEASES 551 \| AVP \| DISEASES 3030 \| HADHA \| DISEASES 56897 \| WRNIP1 \| DISEASES 3717 \| JAK2 \| DISEASES 3875 \| KRT18 \| DISEASES 94 \| ACVRL1 \| DISEASES 51070 \| NOSIP \| DISEASES 29994 \| BAZ2B \| DISEASES 51466 \| EVL \| DISEASES 54903 \| MKS1 \| DISEASES 51520 \| LARS \| DISEASES 91807 \| MYLK3 \| DISEASES 6696 \| SPP1 \| DISEASES 174 \| AFP \| DISEASES 655 \| BMP7 \| DISEASES 728441 \| GGT2 \| DISEASES 1363 \| CPE \| DISEASES 64881 \| PCDH20 \| DISEASES 2641 \| GCG \| DISEASES 8671 \| SLC4A4 \| DISEASES 388552 \| BLOC1S3 \| DISEASES 115677 \| NOSTRIN \| DISEASES 23210 \| JMJD6 \| DISEASES 55683 \| KANSL3 \| DISEASES 7124 \| TNF \| DISEASES 387 \| RHOA \| DISEASES 5817 \| PVR \| DISEASES 9498 \| SLC4A8 \| DISEASES 3276 \| PRMT1 \| DISEASES 408 \| ARRB1 \| DISEASES 3586 \| IL10 \| DISEASES 6434 \| TRA2B \| DISEASES 3077 \| HFE \| DISEASES 284 \| ANGPT1 \| DISEASES 151306 \| GPBAR1 \| DISEASES 5333 \| PLCD1 \| DISEASES 55331 \| ACER3 \| DISEASES 84667 \| HES7 \| DISEASES 9971 \| NR1H4 \| DISEASES 5228 \| PGF \| DISEASES 27229 \| TUBGCP4 \| DISEASES 64506 \| CPEB1 \| DISEASES 9294 \| S1PR2 \| DISEASES 100316868 \| HOTTIP \| DISEASES 100506195 \| LARGE-AS1 \| DISEASES
Locus	(Waiting for update.)

Disease ID	327
Disease	portal hypertension
Integrated Phenotype	(Waiting for update.)
Text Mined Phenotype	HPO \| Name \| Sentences' Count(Total Phenotypes:102) HP:0001394 \| Hepatic cirrhosis \| 162 HP:0001541 \| Ascites \| 36 HP:0002584 \| Intestinal hemorrhage \| 35 HP:0001744 \| Splenomegaly \| 35 HP:0002239 \| Gastrointestinal hemorrhage \| 33 HP:0001971 \| Hypersplenism \| 18 HP:0030242 \| Blood clot in portal vein \| 10 HP:0001399 \| Liver failure \| 10 HP:0030731 \| Carcinoma \| 9 HP:0000822 \| Hypertension \| 8 HP:0005912 \| Biliary duct atresia \| 7 HP:0001402 \| Hepatocellular carcinoma \| 7 HP:0001395 \| Hepatic fibrosis \| 6 HP:0001410 \| Decreased liver function \| 6 HP:0006580 \| Portal fibrosis \| 6 HP:0001873 \| Low platelet count \| 6 HP:0001298 \| Encephalopathy \| 5 HP:0002092 \| Pulmonary artery hypertension \| 4 HP:0001903 \| Anemia \| 4 HP:0002613 \| Biliary cirrhosis \| 4 HP:0004947 \| Arteriovenous fistula \| 4 HP:0002617 \| Aneurysmal dilatation \| 4 HP:0000952 \| Yellow skin \| 4 HP:0012115 \| Liver inflammation \| 3 HP:0000790 \| Hematuria \| 3 HP:0000969 \| Dropsy \| 3 HP:0001405 \| Periportal fibrosis \| 3 HP:0001433 \| Enlarged liver and spleen \| 3 HP:0012126 \| Gastric cancer \| 3 HP:0001733 \| Pancreatic inflammation \| 3 HP:0001876 \| Low blood cell count \| 2 HP:0011002 \| Osteopetrosis \| 2 HP:0200123 \| Chronic liver inflammation \| 2 HP:0011974 \| Myelofibrosis \| 2 HP:0002202 \| Pleural effusion \| 2 HP:0001635 \| Congestive heart failure \| 2 HP:0002240 \| Enlarged liver \| 2 HP:0001909 \| Leukemia \| 2 HP:0001397 \| Hepatic steatosis \| 2 HP:0001747 \| Accessory spleen \| 2 HP:0004936 \| Blood clot in vein \| 2 HP:0002248 \| Vomitting blood \| 2 HP:0002480 \| Hepatic encephalopathy \| 2 HP:0012418 \| Low blood oxygen level \| 2 HP:0100890 \| Cyst of the ductus choledochus \| 2 HP:0100790 \| Hernia \| 2 HP:0002612 \| Congenital hepatic fibrosis \| 2 HP:0012587 \| Gross hematuria \| 1 HP:0001891 \| Iron-deficiency anemia \| 1 HP:0001048 \| Cavernous angioma \| 1 HP:0012649 \| Increased inflammatory response \| 1 HP:0005523 \| Lymphoproliferative disorder \| 1 HP:0000099 \| Glomerular nephritis \| 1 HP:0002583 \| Colitis \| 1 HP:0005263 \| Gastritis \| 1 HP:0011954 \| Nodular transformation of liver \| 1 HP:0002586 \| Peritonitis \| 1 HP:0001875 \| Neutropenia \| 1 HP:0001892 \| Bleeding diathesis \| 1 HP:0005225 \| Intestinal edema \| 1 HP:0002024 \| Intestinal malabsorption \| 1 HP:0002665 \| Lymphoma \| 1 HP:0000855 \| Insulin resistance \| 1 HP:0012223 \| Ruptured spleen \| 1 HP:0002608 \| Celiac disease \| 1 HP:0002573 \| Bloody diarrhea \| 1 HP:0002619 \| Varicose veins \| 1 HP:0001297 \| Cerebral vascular events \| 1 HP:0001978 \| Extramedullary hematopoiesis \| 1 HP:0100033 \| Tic disorder \| 1 HP:0006577 \| Macronodular cirrhosis \| 1 HP:0002664 \| Neoplasia \| 1 HP:0003256 \| Coagulopathy \| 1 HP:0100543 \| Cognitive deficits \| 1 HP:0002902 \| Hyponatremia \| 1 HP:0100699 \| Scarring \| 1 HP:0002910 \| Elevated transaminases \| 1 HP:0002571 \| Achalasia \| 1 HP:0012281 \| Chylous ascites \| 1 HP:0100844 \| Pancreatic fistula \| 1 HP:0100626 \| Chronic hepatic failure \| 1 HP:0030151 \| Cholangitis \| 1 HP:0004836 \| Acute promyelocytic leukemia \| 1 HP:0100646 \| Thyroiditis \| 1 HP:0000872 \| Hashimoto's thyroiditis \| 1 HP:0012550 \| Colonic varices \| 1 HP:0012849 \| Small intestinal hemorrhage \| 1 HP:0012378 \| Fatigue \| 1 HP:0002242 \| Enteropathy \| 1 HP:0100495 \| Mastocytosis \| 1 HP:0001537 \| Umbilical hernias \| 1 HP:0001082 \| Cholecystitis \| 1 HP:0006280 \| Chronic pancreas inflammation \| 1 HP:0002894 \| Neoplasia of the pancreas \| 1 HP:0011034 \| Amyloid disease \| 1 HP:0030243 \| Blood clot in liver vein \| 1 HP:0001028 \| Strawberry mark \| 1 HP:0100806 \| Sepsis \| 1 HP:0012280 \| Hepatic amyloidosis \| 1 HP:0001878 \| Haemolytic anaemia \| 1 HP:0002488 \| Acute leukemias \| 1 HP:0030247 \| Blood clot in splanchnic vein \| 1

Disease ID	327
Disease	portal hypertension
Manually Symptom	UMLS \| Name(Total Manually Symptoms:117) C2707258 \| infections C2676454 \| h syndrome C2609100 \| anorectal varices C2364133 \| infection C2363955 \| venous reflux C2243088 \| hemorrhagic gastritis C2243088 \| haemorrhagic gastritis C2073625 \| pleural effusion C1963935 \| intestinal hyperemia C1963854 \| congestive gastropathy C1963220 \| pulmonary hypertension C1963106 \| esophagitis C1963101 \| encephalopathy C1963091 \| diarrhea C1868851 \| portopulmonary hypertension C1657109 \| general problem C1627365 \| littoral cell angioma C1623038 \| cirrhosis C1619734 \| pulmonary arterial hypertension C1550639 \| fistula C1442984 \| choledochal cyst C1402315 \| vascular lesions C1142158 \| hepatic vein occlusion C1112565 \| pneumatosis intestinalis C0947622 \| gallstones C0941011 \| hemorrhagic gastropathy C0877686 \| colopathy C0856169 \| endothelial dysfunction C0854441 \| gastric mucosal lesion C0854416 \| pulmonary vascular disorders C0796095 \| c syndrome C0748168 \| pulmonary pathology C0748159 \| pulmonary involvement C0740577 \| acute abdominal pain C0600452 \| hepatopulmonary syndrome C0580178 \| duodenal varices C0580174 \| portal hypertensive gastropathy C0426768 \| o sign C0376293 \| stigmata C0348893 \| chronic superficial gastritis C0341608 \| stomal varices C0341244 \| duodenal erosion C0333494 \| phlebosclerosis C0267789 \| mesenteric arteriovenous fistula C0267373 \| intestinal hemorrhages C0267373 \| intestinal hemorrhage C0267373 \| intestinal haemorrhages C0267373 \| intestinal haemorrhage C0267373 \| intestinal bleeding C0267211 \| gastric antral vascular ectasia C0267209 \| bleeding gastric varices C0266807 \| acute gastrointestinal haemorrhage C0266807 \| acute gastrointestinal bleeding C0240318 \| mediastinal mass C0238293 \| osteomyelosclerosis C0235982 \| stricture of bile duct C0235325 \| gastric hemorrhage C0235325 \| gastric haemorrhage C0235325 \| gastric bleeding C0162529 \| ischemic colitis C0162529 \| colonic ischemia C0155789 \| esophageal varices hemorrhage C0155789 \| bleeding oesophageal varices C0155789 \| bleeding esophageal varices C0155773 \| portal vein thrombosis C0155747 \| splenic artery aneurysm C0154307 \| congestive splenomegaly C0152171 \| primary pulmonary hypertension C0085584 \| encephalopathies C0085113 \| von recklinghausen disease C0042345 \| varicosities C0042345 \| varicose veins C0042345 \| varices C0042341 \| varicocele C0041296 \| tuberculosis C0040034 \| thrombocytopenia C0040028 \| hemorrhagic thrombocythemia C0038358 \| gastric ulcer C0038354 \| gastropathy C0038354 \| gastric disease C0032227 \| pleural effusions C0030920 \| peptic ulcers C0030920 \| peptic ulceration C0030920 \| peptic ulcer C0030920 \| gastroduodenal ulcer C0024633 \| mallory-weiss syndrome C0024620 \| primary liver cancer C0024115 \| pulmonary disorders C0023895 \| hepatocellular disease C0023890 \| liver cirrhosis C0020649 \| hypotension C0020625 \| hyponatremia C0020538 \| systemic arterial hypertension C0020532 \| hypersplenism C0020514 \| hyperprolactinemia C0020488 \| sodium retention C0019214 \| hepatosplenomegaly C0019151 \| portal-systemic encephalopathy C0019151 \| hepatic encephalopathy C0019080 \| hemorrhage C0019079 \| hemoptysis C0018926 \| hematemesis C0018926 \| haematemesis C0018920 \| cavernous hemangioma C0018920 \| cavernoma C0017661 \| iga nephropathy C0017205 \| gaucher's disease C0017181 \| gastrointestinal hemorrhage C0017145 \| gastric varix C0017145 \| gastric varices C0014867 \| oesophageal varices C0014867 \| esophageal varices C0008732 \| chylous ascites C0008350 \| cholelithiasis C0004936 \| mental disorders C0002940 \| aneurysms C0002940 \| aneurysm
Text Mined Symptom	UMLS \| Name \| Sentences' Count(Total Symptoms:51) C0023890 \| cirrhosis \| 136 C0042345 \| varices \| 69 C0023890 \| liver cirrhosis \| 43 C0267373 \| intestinal bleeding \| 32 C0014867 \| esophageal varices \| 30 C0020532 \| hypersplenism \| 18 C0019080 \| hemorrhage \| 16 C0426768 \| o sign \| 15 C0017145 \| gastric varices \| 13 C1619734 \| pulmonary arterial hypertension \| 11 C0155773 \| portal vein thrombosis \| 10 C0040034 \| thrombocytopenia \| 6 C0016169 \| fistula \| 5 C0085584 \| encephalopathy \| 5 C0009450 \| infection \| 4 C0014867 \| oesophageal varices \| 4 C0017181 \| gastrointestinal hemorrhage \| 3 C0155747 \| splenic artery aneurysm \| 3 C0019214 \| hepatosplenomegaly \| 3 C0020542 \| pulmonary hypertension \| 3 C0856169 \| endothelial dysfunction \| 3 C0267373 \| intestinal hemorrhage \| 3 C0002940 \| aneurysm \| 2 C0018920 \| cavernoma \| 2 C0002940 \| aneurysms \| 2 C0032227 \| pleural effusion \| 2 C0018926 \| hematemesis \| 2 C0267209 \| bleeding gastric varices \| 2 C0019151 \| hepatic encephalopathy \| 2 C0008340 \| choledochal cyst \| 2 C0600452 \| hepatopulmonary syndrome \| 2 C0235325 \| gastric bleeding \| 1 C0877686 \| colopathy \| 1 C0023895 \| hepatocellular disease \| 1 C1868851 \| portopulmonary hypertension \| 1 C0162529 \| ischemic colitis \| 1 C0018920 \| cavernous hemangioma \| 1 C0042345 \| varicosities \| 1 C0854441 \| gastric mucosal lesion \| 1 C0018926 \| haematemesis \| 1 C0017205 \| gaucher's disease \| 1 C0008732 \| chylous ascites \| 1 C0042345 \| varicose veins \| 1 C0155789 \| bleeding esophageal varices \| 1 C0155789 \| bleeding oesophageal varices \| 1 C0580174 \| portal hypertensive gastropathy \| 1 C0038354 \| gastropathy \| 1 C0020625 \| hyponatremia \| 1 C0266807 \| acute gastrointestinal bleeding \| 1 C0748159 \| pulmonary involvement \| 1 C0341608 \| stomal varices \| 1

Manually Genotype(Total Text Mining Genotypes:0)
(Waiting for update.)

All Snps(Total Genotypes:3)
snpId	pubmedId	geneId	geneSymbol	diseaseId	sourceId	sentence	score	Year	geneSymbol_dbSNP	CHROMOSOME	POS	REF	ALT
rs1799945	11421105	3077	HFE	umls:C0020541	BeFree	We describe here a kindred in which the propositus, being heterozygote for beta-thalassemia and the H63D mutation of the HFE gene, developed severe iron overload and in turn, chronic liver failure with portal hypertension.	0.000542884	2001	HFE	6	26090951	C	G
rs1800562	19440063	1636	ACE	umls:C0020541	BeFree	A 57-year-old white woman had serum ferritin 793 ng/mL, HFE C282Y homozygosity, elevated serum angiotensin-converting enzyme (ACE) levels, 3+ hepatocyte iron, cirrhosis, hepatic granulomas, and portal hypertension.	0.003181358	2009	HFE	6	26092913	G	A
rs1800562	19440063	3077	HFE	umls:C0020541	BeFree	A 57-year-old white woman had serum ferritin 793 ng/mL, HFE C282Y homozygosity, elevated serum angiotensin-converting enzyme (ACE) levels, 3+ hepatocyte iron, cirrhosis, hepatic granulomas, and portal hypertension.	0.000542884	2009	HFE	6	26092913	G	A

GWASdb Annotation(Total Genotypes:0)
(Waiting for update.)

GWASdb Snp Trait(Total Genotypes:0)
(Waiting for update.)

Mapped by lexical matching(Total Items:0)
(Waiting for update.)

Mapped by homologous gene(Total Items:0)
(Waiting for update.)

Chemical(Total Drugs:10)
CUI	ChemicalName	ChemicalID	CasRN	DiseaseName	DiseaseID	DirectEvidence	PubMedIDs
C0020541	busulfan	D002066	55-98-1	hypertension, portal	MESH:D006975	marker/mechanism	267281
C0020541	glutathione	D005978	70-18-8	hypertension, portal	MESH:D006975	marker/mechanism	15962377
C0020541	methotrexate	D008727	1959/5/2	hypertension, portal	MESH:D006975	marker/mechanism	5695945
C0020541	nitric oxide	D009569	10102-43-9	hypertension, portal	MESH:D006975	marker/mechanism	15962377
C0020541	octreotide	D015282	83150-76-9	hypertension, portal	MESH:D006975	therapeutic	9930395
C0020541	propranolol	D011433	525-66-6	hypertension, portal	MESH:D006975	therapeutic	10197489
C0020541	spironolactone	D013148	1952/1/7	hypertension, portal	MESH:D006975	therapeutic	12385542
C0020541	thalidomide	D013792	50-35-1	hypertension, portal	MESH:D006975	therapeutic	14687169
C0020541	vitamin a	D014801	11103-57-4	hypertension, portal	MESH:D006975	marker/mechanism	10750659
C0020541	zidovudine	D015215	30516-87-1	hypertension, portal	MESH:D006975	marker/mechanism	11556343

FDA approved drug and dosage information(Total Drugs:0)
(Waiting for update.)

FDA labeling changes(Total Drugs:0)
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