PedAM

Pediatric Disease Annotations & Medicines


	polyradiculoneuropathy

Disease ID	1824
Disease	polyradiculoneuropathy
Definition	Diseases characterized by injury or dysfunction involving multiple peripheral nerves and nerve roots. The process may primarily affect myelin or nerve axons. Two of the more common demyelinating forms are acute inflammatory polyradiculopathy (GUILLAIN-BARRE SYNDROME) and POLYRADICULONEUROPATHY, CHRONIC INFLAMMATORY DEMYELINATING. Polyradiculoneuritis refers to inflammation of multiple peripheral nerves and spinal nerve roots.
Synonym	polyradiculoneuropathies polyradiculoneuropathy (disorder) polyradiculoneuropathy [disease/finding]
DOID	DOID:4308
UMLS	C0032587
MeSH	D011129
SNOMED-CT	SNOMEDCT_US_2016_09_01:128078004
Comorbidity	UMLS \| Disease \| Sentences' Count(Total Sentences:11) C0409974 \| lupus erythematosus \| 1 C0023418 \| leukemia \| 1 C0019158 \| hepatitis \| 1 C0024141 \| systemic lupus erythematosus \| 1 C0027726 \| nephrotic syndrome \| 1 C0011849 \| diabetes mellitus \| 1 C0010346 \| crohn's disease \| 1 C0023448 \| lymphoblastic leukemia \| 1 C0011847 \| diabetes \| 1 C0023449 \| acute lymphoblastic leukemia \| 1 C0085293 \| hepatitis e \| 1
Curated Gene	(Waiting for update.)
Inferring Gene	(Waiting for update.)
Text Mined Gene	Entrez_id \| Symbol \| Score \| Resource(Total Genes:162) 8935 \| SKAP2 \| DISEASES 9741 \| LAPTM4A \| DISEASES 10857 \| PGRMC1 \| DISEASES 10916 \| MAGED2 \| DISEASES 54332 \| GDAP1 \| DISEASES 7040 \| TGFB1 \| DISEASES 973 \| CD79A \| DISEASES 81622 \| UNC93B1 \| DISEASES 3458 \| IFNG \| DISEASES 4188 \| MDFI \| DISEASES 2916 \| GRM6 \| DISEASES 56920 \| SEMA3G \| DISEASES 51185 \| CRBN \| DISEASES 7276 \| TTR \| DISEASES 9519 \| TBPL1 \| DISEASES 968 \| CD68 \| DISEASES 2670 \| GFAP \| DISEASES 5989 \| RFX1 \| DISEASES 1401 \| CRP \| DISEASES 10643 \| IGF2BP3 \| DISEASES 3569 \| IL6 \| DISEASES 971 \| CD72 \| DISEASES 3417 \| IDH1 \| DISEASES 9480 \| ONECUT2 \| DISEASES 9172 \| MYOM2 \| DISEASES 25939 \| SAMHD1 \| DISEASES 443 \| ASPA \| DISEASES 3553 \| IL1B \| DISEASES 9424 \| KCNK6 \| DISEASES 3299 \| HSF4 \| DISEASES 200576 \| PIKFYVE \| DISEASES 8506 \| CNTNAP1 \| DISEASES 3383 \| ICAM1 \| DISEASES 25996 \| REXO2 \| DISEASES 6455 \| SH3GL1 \| DISEASES 2495 \| FTH1 \| DISEASES 890 \| CCNA2 \| DISEASES 23500 \| DAAM2 \| DISEASES 7462 \| LAT2 \| DISEASES 55909 \| BIN3 \| DISEASES 340419 \| RSPO2 \| DISEASES 4851 \| NOTCH1 \| DISEASES 6506 \| SLC1A2 \| DISEASES 651 \| BMP3 \| DISEASES 9510 \| ADAMTS1 \| DISEASES 56896 \| DPYSL5 \| DISEASES 729230 \| CCR2 \| DISEASES 1234 \| CCR5 \| DISEASES 6368 \| CCL23 \| DISEASES 3549 \| IHH \| DISEASES 213 \| ALB \| DISEASES 1230 \| CCR1 \| DISEASES 9311 \| ASIC3 \| DISEASES 382 \| ARF6 \| DISEASES 4314 \| MMP3 \| DISEASES 6632 \| SNRPD1 \| DISEASES 3627 \| CXCL10 \| DISEASES 2915 \| GRM5 \| DISEASES 114990 \| VASN \| DISEASES 4135 \| MAP6 \| DISEASES 5376 \| PMP22 \| DISEASES 8658 \| TNKS \| DISEASES 64236 \| PDLIM2 \| DISEASES 133522 \| PPARGC1B \| DISEASES 5062 \| PAK2 \| DISEASES 66037 \| BOLL \| DISEASES 129563 \| DIS3L2 \| DISEASES 1604 \| CD55 \| DISEASES 6863 \| TAC1 \| DISEASES 9242 \| MSC \| DISEASES 923 \| CD6 \| DISEASES 1272 \| CNTN1 \| DISEASES 221937 \| FOXK1 \| DISEASES 6900 \| CNTN2 \| DISEASES 126282 \| TNFAIP8L1 \| DISEASES 3418 \| IDH2 \| DISEASES 942 \| CD86 \| DISEASES 153571 \| C5orf38 \| DISEASES 5138 \| PDE2A \| DISEASES 5133 \| PDCD1 \| DISEASES 342035 \| GLDN \| DISEASES 9138 \| ARHGEF1 \| DISEASES 554 \| AVPR2 \| DISEASES 113675 \| SDSL \| DISEASES 6614 \| SIGLEC1 \| DISEASES 5764 \| PTN \| DISEASES 132884 \| EVC2 \| DISEASES 3605 \| IL17A \| DISEASES 467 \| ATF3 \| DISEASES 23114 \| NFASC \| DISEASES 23481 \| PES1 \| DISEASES 273 \| AMPH \| DISEASES 135250 \| RAET1E \| DISEASES 4763 \| NF1 \| DISEASES 55010 \| PARPBP \| DISEASES 84867 \| PTPN5 \| DISEASES 51603 \| METTL13 \| DISEASES 5743 \| PTGS2 \| DISEASES 7957 \| EPM2A \| DISEASES 910 \| CD1B \| DISEASES 57657 \| HCN3 \| DISEASES 1892 \| ECHS1 \| DISEASES 4803 \| NGF \| DISEASES 164045 \| HFM1 \| DISEASES 60495 \| HPSE2 \| DISEASES 959 \| CD40LG \| DISEASES 5730 \| PTGDS \| DISEASES 29991 \| OBP2A \| DISEASES 7422 \| VEGFA \| DISEASES 5476 \| CTSA \| DISEASES 26190 \| FBXW2 \| DISEASES 2914 \| GRM4 \| DISEASES 4593 \| MUSK \| DISEASES 1896 \| EDA \| DISEASES 27301 \| APEX2 \| DISEASES 199 \| AIF1 \| DISEASES 7133 \| TNFRSF1B \| DISEASES 57449 \| PLEKHG5 \| DISEASES 650 \| BMP2 \| DISEASES 4897 \| NRCAM \| DISEASES 5212 \| VIT \| DISEASES 3456 \| IFNB1 \| DISEASES 51199 \| NIN \| DISEASES 4155 \| MBP \| DISEASES 56953 \| NT5M \| DISEASES 54476 \| RNF216 \| DISEASES 340152 \| ZC3H12D \| DISEASES 11202 \| KLK8 \| DISEASES 11009 \| IL24 \| DISEASES 4099 \| MAG \| DISEASES 9047 \| SH2D2A \| DISEASES 9244 \| CRLF1 \| DISEASES 78996 \| C7orf49 \| DISEASES 6152 \| RPL24 \| DISEASES 6164 \| RPL34 \| DISEASES 93487 \| MAPK1IP1L \| DISEASES 3652 \| IPP \| DISEASES 594857 \| NPS \| DISEASES 3803 \| KIR2DL2 \| DISEASES 23308 \| ICOSLG \| DISEASES 7122 \| CLDN5 \| DISEASES 176 \| ACAN \| DISEASES 9048 \| ARTN \| DISEASES 4908 \| NTF3 \| DISEASES 7124 \| TNF \| DISEASES 388372 \| CCL4L1 \| DISEASES 139728 \| PNCK \| DISEASES 30836 \| DNTTIP2 \| DISEASES 3586 \| IL10 \| DISEASES 627 \| BDNF \| DISEASES 6229 \| RPS24 \| DISEASES 3712 \| IVD \| DISEASES 56034 \| PDGFC \| DISEASES 4359 \| MPZ \| DISEASES 3347 \| HTN3 \| DISEASES 55733 \| HHAT \| DISEASES 83857 \| TMTC1 \| DISEASES 4850 \| CNOT4 \| DISEASES 102723508 \| KANTR \| DISEASES 4568 \| MT-TL2 \| DISEASES 103752588 \| PACERR \| DISEASES 26766 \| RNU105C \| DISEASES
Locus	(Waiting for update.)

Disease ID	1824
Disease	polyradiculoneuropathy
Integrated Phenotype	(Waiting for update.)
Text Mined Phenotype	HPO \| Name \| Sentences' Count(Total Phenotypes:17) HP:0100280 \| Morbus Crohn \| 1 HP:0000100 \| Nephrosis \| 1 HP:0012078 \| Motor conduction block \| 1 HP:0001347 \| Hyperreflexia \| 1 HP:0003690 \| Limb weakness \| 1 HP:0002960 \| Autoimmune condition \| 1 HP:0011096 \| Demyelination \| 1 HP:0000819 \| Diabetes mellitus \| 1 HP:0006824 \| Cranial nerve palsy \| 1 HP:0002725 \| Systemic lupus erythematosus \| 1 HP:0002273 \| Tetraparesis \| 1 HP:0001284 \| Areflexia \| 1 HP:0006721 \| Acute lymphocytic leukemia \| 1 HP:0001909 \| Leukemia \| 1 HP:0007340 \| Lower limb weakness \| 1 HP:0012115 \| Liver inflammation \| 1 HP:0200119 \| Acute liver inflammation \| 1

Disease ID	1824
Disease	polyradiculoneuropathy
Manually Symptom	(Waiting for update.)
Text Mined Symptom	(Waiting for update.)

Manually Genotype(Total Text Mining Genotypes:0)
(Waiting for update.)

All Snps(Total Genotypes:0)
(Waiting for update.)

GWASdb Annotation(Total Genotypes:0)
(Waiting for update.)

GWASdb Snp Trait(Total Genotypes:0)
(Waiting for update.)

Mapped by lexical matching(Total Items:0)
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Mapped by homologous gene(Total Items:0)
(Waiting for update.)

Chemical(Total Drugs:3)
CUI	ChemicalName	ChemicalID	CasRN	DiseaseName	DiseaseID	DirectEvidence	PubMedIDs
C0032587	albendazole	D015766	54965-21-8	polyradiculoneuropathy	MESH:D011129	marker/mechanism	8736154
C0032587	amitriptyline	D000639	50-48-6	polyradiculoneuropathy	MESH:D011129	marker/mechanism	2108779
C0032587	vincristine	D014750	-	polyradiculoneuropathy	MESH:D011129	marker/mechanism	17594344

FDA approved drug and dosage information(Total Drugs:0)
(Waiting for update.)

FDA labeling changes(Total Drugs:0)
(Waiting for update.)

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