PedAM

Pediatric Disease Annotations & Medicines


	polyneuropathy

Disease ID	844
Disease	polyneuropathy
Definition	Diseases of multiple peripheral nerves simultaneously. Polyneuropathies usually are characterized by symmetrical, bilateral distal motor and sensory impairment with a graded increase in severity distally. The pathological processes affecting peripheral nerves include degeneration of the axon, myelin or both. The various forms of polyneuropathy are categorized by the type of nerve affected (e.g., sensory, motor, or autonomic), by the distribution of nerve injury (e.g., distal vs. proximal), by nerve component primarily affected (e.g., demyelinating vs. axonal), by etiology, or by pattern of inheritance.
Synonym	[x]polyneuropathy, unspecified [x]polyneuropathy, unspecified (disorder) polyneuropathies polyneuropathies [disease/finding] polyneuropathy (disorder) polyneuropathy (multiple nerve disorder) polyneuropathy unspecified polyneuropathy unspecified (disorder) polyneuropathy, nos
DOID	DOID:1389
UMLS	C0152025
MeSH	D011115
SNOMED-CT	SNOMEDCT_US_2016_09_01:42345000
Comorbidity	UMLS \| Disease \| Sentences' Count(Total Sentences:122) C0011847 \| diabetes \| 22 C1136085 \| monoclonal gammopathy \| 13 C0002726 \| amyloidosis \| 10 C0011849 \| diabetes mellitus \| 9 C0011860 \| type 2 diabetes \| 5 C0085404 \| poems syndrome \| 5 C0011854 \| type 1 diabetes \| 5 C0004134 \| ataxia \| 4 C0018801 \| heart failure \| 3 C0026470 \| monoclonal gammopathy of undetermined significance \| 3 C0020676 \| hypothyroidism \| 3 C1834580 \| ramsay hunt syndrome \| 3 C0020676 \| hypothyroid \| 3 C0002736 \| amyotrophic lateral sclerosis \| 3 C0442874 \| neuropathy \| 3 C0008728 \| churg-strauss syndrome \| 3 C1136084 \| plasma cell dyscrasia \| 2 C1145670 \| respiratory failure \| 2 C0007286 \| carpal tunnel syndrome \| 2 C0018378 \| guillain-barre syndrome \| 2 C0032131 \| plasmacytoma \| 2 C0159069 \| impaired glucose tolerance \| 2 C0241910 \| autoimmune hepatitis \| 2 C0022658 \| kidney disease \| 2 C0014070 \| encephalomyelitis \| 2 C0003873 \| rheumatoid arthritis \| 2 C0020456 \| hyperglycemia \| 2 C0242287 \| neuromyotonia \| 2 C0035309 \| retinopathy \| 2 C0149925 \| small cell carcinoma \| 2 C0006142 \| breast cancer \| 2 C0019360 \| zoster \| 2 C0494491 \| mononeuropathy \| 2 C0007115 \| thyroid ca \| 2 C0011570 \| depression \| 2 C0700594 \| radiculopathy \| 2 C0019158 \| hepatitis \| 1 C0024299 \| lymphomas \| 1 C0025202 \| malignant melanoma \| 1 C0684249 \| carcinoma of the lung \| 1 C0017409 \| herpes zoster oticus \| 1 C0026846 \| muscle atrophy \| 1 C0017668 \| focal segmental glomerulosclerosis \| 1 C0023520 \| leukodystrophy \| 1 C0023801 \| madelung's disease \| 1 C0022661 \| end stage kidney disease \| 1 C0497327 \| dementia \| 1 C0019163 \| hepatitis b \| 1 C0007959 \| charcot-marie-tooth disease \| 1 C0008312 \| primary biliary cirrhosis \| 1 C0235270 \| keratopathy \| 1 C0024305 \| non-hodgkin's lymphoma \| 1 C0151295 \| mononeuritis multiplex \| 1 C0027765 \| neurological disorders \| 1 C0023788 \| whipple's disease \| 1 C1704436 \| peripheral arterial disease \| 1 C0021053 \| immune disease \| 1 C0393819 \| chronic inflammatory demyelinating polyneuropathy \| 1 C0020538 \| hypertension \| 1 C0043121 \| wernicke's encephalopathy \| 1 C0206138 \| crest syndrome \| 1 C0086543 \| cataract \| 1 C0852949 \| arterial disease \| 1 C0020550 \| hyperthyroidism \| 1 C0027726 \| nephrotic syndrome \| 1 C0007785 \| cerebral infarction \| 1 C0017665 \| membranous nephropathy \| 1 C0027765 \| neurological disorder \| 1 C0041234 \| chagas disease \| 1 C0013384 \| dyskinesia \| 1 C0023890 \| cirrhosis \| 1 C0270921 \| axonal neuropathy \| 1 C0025202 \| melanoma \| 1 C0027765 \| neurological disease \| 1 C0149925 \| small cell carcinoma of the lung \| 1 C0007785 \| cerebral infarct \| 1 C0040034 \| thrombocytopenia \| 1 C0238052 \| cerebrotendinous xanthomatosis \| 1 C0035078 \| renal failure \| 1 C0014544 \| epilepsy \| 1 C0012546 \| diphtheria \| 1 C0017205 \| gaucher disease \| 1 C0022658 \| nephropathy \| 1 C0079731 \| b-cell non-hodgkin's lymphoma \| 1 C0026975 \| myelitis \| 1 C0030567 \| parkinson disease \| 1 C0751651 \| mitochondrial disease \| 1 C0013720 \| ehlers-danlos syndrome \| 1 C0011860 \| diabetes mellitus type 2 \| 1 C1510471 \| hypovitaminosis \| 1 C0018784 \| sensorineural hearing loss \| 1 C0022661 \| chronic renal failure \| 1 C0008312 \| biliary cirrhosis \| 1 C1333292 \| diffuse infiltrative lymphocytosis syndrome \| 1 C0004943 \| behcet's disease \| 1 C0042075 \| urological diseases \| 1 C0035258 \| restless legs syndrome \| 1 C0019829 \| hodgkin's lymphoma \| 1 C0007570 \| celiac disease \| 1 C0004096 \| asthma \| 1 C0042373 \| vascular disease \| 1 C0035258 \| restless legs \| 1 C0007758 \| cerebellar ataxia \| 1 C0032587 \| polyradiculoneuropathy \| 1 C0948265 \| metabolic syndrome \| 1 C0011854 \| type 1 diabetes mellitus \| 1 C0032131 \| solitary plasmacytoma \| 1 C0270922 \| demyelinating polyneuropathy \| 1 C0035258 \| restless legs syndrome (rls) \| 1 C0007222 \| cardiovascular disease \| 1 C0268407 \| cardiac amyloidosis \| 1 C0524851 \| neurodegenerative disease \| 1 C0014868 \| esophagitis \| 1 C1510471 \| vitamin deficiency \| 1 C0030567 \| parkinson's disease \| 1 C0030486 \| paraplegia \| 1 C0019360 \| herpes zoster \| 1 C0011860 \| type 2 diabetes mellitus \| 1 C0007137 \| squamous cell carcinoma \| 1 C0011854 \| diabetes mellitus type 1 \| 1 C0002170 \| alopecia \| 1 C0042075 \| urological disorders \| 1
Curated Gene	Entrez_id \| Symbol \| Resource(Total Genes:3) PNPLA6 \| 10908 \| CTD_human EPO \| 2056 \| CTD_human SCP2 \| 6342 \| CTD_human
Inferring Gene	Entrez_id \| Symbol \| Resource(Total Genes:3) 3123 \| HLA-DRB1 \| infer 4567 \| MT-TL1 \| infer 5376 \| PMP22 \| infer
Text Mined Gene	Entrez_id \| Symbol \| Score \| Resource(Total Genes:293) 8935 \| SKAP2 \| DISEASES 5662 \| PSD \| DISEASES 7132 \| TNFRSF1A \| DISEASES 9741 \| LAPTM4A \| DISEASES 5607 \| MAP2K5 \| DISEASES 27248 \| ERLEC1 \| DISEASES 51324 \| SPG21 \| DISEASES 8086 \| AAAS \| DISEASES 22880 \| MORC2 \| DISEASES 410 \| ARSA \| DISEASES 54332 \| GDAP1 \| DISEASES 4051 \| CYP4F3 \| DISEASES 973 \| CD79A \| DISEASES 23064 \| SETX \| DISEASES 1440 \| CSF3 \| DISEASES 6347 \| CCL2 \| DISEASES 4126 \| MANBA \| DISEASES 1410 \| CRYAB \| DISEASES 3458 \| IFNG \| DISEASES 8078 \| USP5 \| DISEASES 2026 \| ENO2 \| DISEASES 9896 \| FIG4 \| DISEASES 4188 \| MDFI \| DISEASES 4358 \| MPV17 \| DISEASES 5657 \| PRTN3 \| DISEASES 9927 \| MFN2 \| DISEASES 335 \| APOA1 \| DISEASES 7276 \| TTR \| DISEASES 3375 \| IAPP \| DISEASES 80218 \| NAA50 \| DISEASES 1959 \| EGR2 \| DISEASES 23550 \| PSD4 \| DISEASES 968 \| CD68 \| DISEASES 482 \| ATP1B2 \| DISEASES 6351 \| CCL4 \| DISEASES 3630 \| INS \| DISEASES 23503 \| ZFYVE26 \| DISEASES 11026 \| LILRA3 \| DISEASES 3040 \| HBA2 \| DISEASES 1890 \| TYMP \| DISEASES 2056 \| EPO \| DISEASES 25814 \| ATXN10 \| DISEASES 59335 \| PRDM12 \| DISEASES 6737 \| TRIM21 \| DISEASES 10462 \| CLEC10A \| DISEASES 1401 \| CRP \| DISEASES 325 \| APCS \| DISEASES 3508 \| IGHMBP2 \| DISEASES 81846 \| SBF2 \| DISEASES 2694 \| GIF \| DISEASES 3569 \| IL6 \| DISEASES 3557 \| IL1RN \| DISEASES 9585 \| KIF20B \| DISEASES 6741 \| SSB \| DISEASES 1419 \| CRYGB \| DISEASES 4069 \| LYZ \| DISEASES 2581 \| GALC \| DISEASES 80208 \| SPG11 \| DISEASES 9172 \| MYOM2 \| DISEASES 8731 \| RNMT \| DISEASES 9837 \| GINS1 \| DISEASES 25939 \| SAMHD1 \| DISEASES 5264 \| PHYH \| DISEASES 3553 \| IL1B \| DISEASES 23095 \| KIF1B \| DISEASES 3299 \| HSF4 \| DISEASES 941 \| CD80 \| DISEASES 10190 \| TXNDC9 \| DISEASES 2247 \| FGF2 \| DISEASES 8506 \| CNTNAP1 \| DISEASES 5443 \| POMC \| DISEASES 3383 \| ICAM1 \| DISEASES 25996 \| REXO2 \| DISEASES 5286 \| PIK3C2A \| DISEASES 3700 \| ITIH4 \| DISEASES 50846 \| DHH \| DISEASES 5428 \| POLG \| DISEASES 5373 \| PMM2 \| DISEASES 432 \| ASGR1 \| DISEASES 2014 \| EMP3 \| DISEASES 10637 \| LEFTY1 \| DISEASES 84249 \| PSD2 \| DISEASES 23500 \| DAAM2 \| DISEASES 5723 \| PSPH \| DISEASES 7462 \| LAT2 \| DISEASES 55909 \| BIN3 \| DISEASES 11160 \| ERLIN2 \| DISEASES 340419 \| RSPO2 \| DISEASES 3439 \| IFNA1 \| DISEASES 4851 \| NOTCH1 \| DISEASES 3606 \| IL18 \| DISEASES 51232 \| CRIM1 \| DISEASES 7345 \| UCHL1 \| DISEASES 9510 \| ADAMTS1 \| DISEASES 9069 \| CLDN12 \| DISEASES 56896 \| DPYSL5 \| DISEASES 1636 \| ACE \| DISEASES 6285 \| S100B \| DISEASES 729230 \| CCR2 \| DISEASES 824 \| CAPN2 \| DISEASES 476 \| ATP1A1 \| DISEASES 3549 \| IHH \| DISEASES 213 \| ALB \| DISEASES 10922 \| FASTK \| DISEASES 9907 \| AP5Z1 \| DISEASES 90678 \| LRSAM1 \| DISEASES 27249 \| MMADHC \| DISEASES 43 \| ACHE \| DISEASES 171558 \| PTCRA \| DISEASES 3627 \| CXCL10 \| DISEASES 114990 \| VASN \| DISEASES 5376 \| PMP22 \| DISEASES 8534 \| CHST1 \| DISEASES 55790 \| CSGALNACT1 \| DISEASES 64236 \| PDLIM2 \| DISEASES 246243 \| RNASEH1 \| DISEASES 653499 \| LGALS7B \| DISEASES 66037 \| BOLL \| DISEASES 129563 \| DIS3L2 \| DISEASES 5191 \| PEX7 \| DISEASES 1604 \| CD55 \| DISEASES 10397 \| NDRG1 \| DISEASES 80381 \| CD276 \| DISEASES 6683 \| SPAST \| DISEASES 6863 \| TAC1 \| DISEASES 3039 \| HBA1 \| DISEASES 923 \| CD6 \| DISEASES 8706 \| B3GALNT1 \| DISEASES 11284 \| PNKP \| DISEASES 9282 \| MED14 \| DISEASES 79054 \| TRPM8 \| DISEASES 23362 \| PSD3 \| DISEASES 3032 \| HADHB \| DISEASES 1272 \| CNTN1 \| DISEASES 6906 \| SERPINA7 \| DISEASES 6656 \| SOX1 \| DISEASES 6900 \| CNTN2 \| DISEASES 6401 \| SELE \| DISEASES 126282 \| TNFAIP8L1 \| DISEASES 3418 \| IDH2 \| DISEASES 942 \| CD86 \| DISEASES 5138 \| PDE2A \| DISEASES 342035 \| GLDN \| DISEASES 10957 \| PNRC1 \| DISEASES 84186 \| ZCCHC7 \| DISEASES 554 \| AVPR2 \| DISEASES 9516 \| LITAF \| DISEASES 966 \| CD59 \| DISEASES 9639 \| ARHGEF10 \| DISEASES 3605 \| IL17A \| DISEASES 467 \| ATF3 \| DISEASES 875 \| CBS \| DISEASES 56704 \| JPH1 \| DISEASES 4771 \| NF2 \| DISEASES 23114 \| NFASC \| DISEASES 8898 \| MTMR2 \| DISEASES 23481 \| PES1 \| DISEASES 93979 \| CPA5 \| DISEASES 3240 \| HP \| DISEASES 118813 \| ZFYVE27 \| DISEASES 273 \| AMPH \| DISEASES 22931 \| RAB18 \| DISEASES 1996 \| ELAVL4 \| DISEASES 337 \| APOA4 \| DISEASES 4763 \| NF1 \| DISEASES 55010 \| PARPBP \| DISEASES 84867 \| PTPN5 \| DISEASES 2213 \| FCGR2B \| DISEASES 617 \| BCS1L \| DISEASES 9197 \| SLC33A1 \| DISEASES 4478 \| MSN \| DISEASES 23230 \| VPS13A \| DISEASES 83666 \| PARP9 \| DISEASES 26580 \| BSCL2 \| DISEASES 26047 \| CNTNAP2 \| DISEASES 2705 \| GJB1 \| DISEASES 4283 \| CXCL9 \| DISEASES 51603 \| METTL13 \| DISEASES 1270 \| CNTF \| DISEASES 23596 \| OPN3 \| DISEASES 28982 \| FLVCR1 \| DISEASES 336 \| APOA2 \| DISEASES 480 \| ATP1A4 \| DISEASES 913 \| CD1E \| DISEASES 910 \| CD1B \| DISEASES 4000 \| LMNA \| DISEASES 57657 \| HCN3 \| DISEASES 10758 \| TRAF3IP2 \| DISEASES 9531 \| BAG3 \| DISEASES 26227 \| PHGDH \| DISEASES 4803 \| NGF \| DISEASES 164045 \| HFM1 \| DISEASES 959 \| CD40LG \| DISEASES 9211 \| LGI1 \| DISEASES 5950 \| RBP4 \| DISEASES 29991 \| OBP2A \| DISEASES 6834 \| SURF1 \| DISEASES 7422 \| VEGFA \| DISEASES 4318 \| MMP9 \| DISEASES 5476 \| CTSA \| DISEASES 2934 \| GSN \| DISEASES 714 \| C1QC \| DISEASES 27301 \| APEX2 \| DISEASES 4237 \| MFAP2 \| DISEASES 4958 \| OMD \| DISEASES 199 \| AIF1 \| DISEASES 7133 \| TNFRSF1B \| DISEASES 1041 \| CDSN \| DISEASES 26090 \| ABHD12 \| DISEASES 1471 \| CST3 \| DISEASES 11166 \| SOX21 \| DISEASES 3963 \| LGALS7 \| DISEASES 650 \| BMP2 \| DISEASES 644096 \| SDHAF1 \| DISEASES 4897 \| NRCAM \| DISEASES 5621 \| PRNP \| DISEASES 51360 \| MBTPS2 \| DISEASES 390598 \| SKOR1 \| DISEASES 3440 \| IFNA2 \| DISEASES 3456 \| IFNB1 \| DISEASES 551 \| AVP \| DISEASES 3030 \| HADHA \| DISEASES 51199 \| NIN \| DISEASES 26278 \| SACS \| DISEASES 4155 \| MBP \| DISEASES 361 \| AQP4 \| DISEASES 56953 \| NT5M \| DISEASES 54476 \| RNF216 \| DISEASES 11202 \| KLK8 \| DISEASES 4099 \| MAG \| DISEASES 9047 \| SH2D2A \| DISEASES 9244 \| CRLF1 \| DISEASES 64423 \| INF2 \| DISEASES 12 \| SERPINA3 \| DISEASES 78996 \| C7orf49 \| DISEASES 4287 \| ATXN3 \| DISEASES 51520 \| LARS \| DISEASES 6164 \| RPL34 \| DISEASES 93487 \| MAPK1IP1L \| DISEASES 27327 \| TNRC6A \| DISEASES 7920 \| ABHD16A \| DISEASES 594857 \| NPS \| DISEASES 29965 \| CDIP1 \| DISEASES 7442 \| TRPV1 \| DISEASES 8091 \| HMGA2 \| DISEASES 7122 \| CLDN5 \| DISEASES 7018 \| TF \| DISEASES 114781 \| BTBD9 \| DISEASES 210 \| ALAD \| DISEASES 176 \| ACAN \| DISEASES 23533 \| PIK3R5 \| DISEASES 121512 \| FGD4 \| DISEASES 5783 \| PTPN13 \| DISEASES 387836 \| CLEC2A \| DISEASES 734 \| OSGIN2 \| DISEASES 4908 \| NTF3 \| DISEASES 7124 \| TNF \| DISEASES 3908 \| LAMA2 \| DISEASES 388372 \| CCL4L1 \| DISEASES 10908 \| PNPLA6 \| DISEASES 7148 \| TNXB \| DISEASES 3798 \| KIF5A \| DISEASES 7555 \| CNBP \| DISEASES 2632 \| GBE1 \| DISEASES 30836 \| DNTTIP2 \| DISEASES 22930 \| RAB3GAP1 \| DISEASES 3586 \| IL10 \| DISEASES 627 \| BDNF \| DISEASES 3712 \| IVD \| DISEASES 6949 \| TCOF1 \| DISEASES 79628 \| SH3TC2 \| DISEASES 23022 \| PALLD \| DISEASES 4914 \| NTRK1 \| DISEASES 3297 \| HSF1 \| DISEASES 4359 \| MPZ \| DISEASES 930 \| CD19 \| DISEASES 23312 \| DMXL2 \| DISEASES 83857 \| TMTC1 \| DISEASES 51550 \| CINP \| DISEASES 10381 \| TUBB3 \| DISEASES 9990 \| SLC12A6 \| DISEASES 567 \| B2M \| DISEASES 2585 \| GALK2 \| DISEASES 820 \| CAMP \| DISEASES 29115 \| SAP30BP \| DISEASES 81033 \| KCNH6 \| DISEASES 102723508 \| KANTR \| DISEASES 100506195 \| LARGE-AS1 \| DISEASES 338799 \| LINC01089 \| DISEASES 4568 \| MT-TL2 \| DISEASES 4573 \| MT-TR \| DISEASES 26766 \| RNU105C \| DISEASES 23642 \| SNHG1 \| DISEASES
Locus	(Waiting for update.)

Disease ID	844
Disease	polyneuropathy
Integrated Phenotype	(Waiting for update.)
Text Mined Phenotype	HPO \| Name \| Sentences' Count(Total Phenotypes:87) HP:0011034 \| Amyloid disease \| 10 HP:0000819 \| Diabetes mellitus \| 9 HP:0003447 \| Axonal loss \| 5 HP:0001251 \| Ataxia \| 4 HP:0001635 \| Congestive heart failure \| 4 HP:0012531 \| Pain \| 4 HP:0002459 \| Dysautonomia \| 4 HP:0001324 \| Muscular weakness \| 4 HP:0030731 \| Carcinoma \| 3 HP:0000821 \| Underactive thyroid \| 3 HP:0007354 \| Amyotrophic lateral sclerosis \| 3 HP:0002747 \| Respiratory distress due to muscle weakness \| 2 HP:0003470 \| Inability to move \| 2 HP:0011096 \| Demyelination \| 2 HP:0002664 \| Neoplasia \| 2 HP:0000716 \| Depression \| 2 HP:0010871 \| Ataxia, sensory \| 2 HP:0001337 \| Tremor \| 2 HP:0002015 \| Swallowing difficulty \| 2 HP:0011857 \| Plasmacytoma \| 2 HP:0001760 \| Foot deformities \| 2 HP:0009831 \| Single damaged nerve \| 2 HP:0003074 \| High blood glucose \| 2 HP:0000833 \| Glucose intolerance \| 2 HP:0001298 \| Encephalopathy \| 2 HP:0000488 \| Noninflammatory retina disease \| 2 HP:0002878 \| Respiratory failure \| 2 HP:0003002 \| Breast carcinoma \| 2 HP:0012534 \| Dysesthesia \| 2 HP:0001370 \| Rheumatoid arthritis \| 2 HP:0000518 \| Cataract \| 1 HP:0000822 \| Hypertension \| 1 HP:0003401 \| Paresthesia \| 1 HP:0000407 \| sensorineural hearing loss \| 1 HP:0012486 \| Inflammation of spinal cord \| 1 HP:0000112 \| Nephropathy \| 1 HP:0000726 \| Dementia \| 1 HP:0000100 \| Nephrosis \| 1 HP:0000836 \| Overactive thyroid \| 1 HP:0000708 \| Behavioral problems \| 1 HP:0002597 \| Abnormality of blood vessels \| 1 HP:0001394 \| Hepatic cirrhosis \| 1 HP:0200029 \| Cutaneous vasculitis \| 1 HP:0003774 \| End-stage renal failure \| 1 HP:0001278 \| Orthostatic hypotension \| 1 HP:0001873 \| Low platelet count \| 1 HP:0004349 \| Reduced bone mineral density \| 1 HP:0006597 \| Paralyzed diaphragm \| 1 HP:0012189 \| Hodgkin disease \| 1 HP:0007418 \| Alopecia totalis \| 1 HP:0012115 \| Liver inflammation \| 1 HP:0002861 \| Melanoma \| 1 HP:0012578 \| Membranous glomerulonephritis \| 1 HP:0006824 \| Cranial nerve palsy \| 1 HP:0002378 \| Hand tremor \| 1 HP:0002180 \| Neurodegeneration \| 1 HP:0003477 \| Peripheral axonal neuropathy \| 1 HP:0030843 \| Cardiac amyloidosis \| 1 HP:0002613 \| Biliary cirrhosis \| 1 HP:0100633 \| Inflammation of the esophagus \| 1 HP:0002273 \| Tetraparesis \| 1 HP:0100033 \| Tic disorder \| 1 HP:0003474 \| Sensory impairment \| 1 HP:0002415 \| Degeneration of white matter of brain \| 1 HP:0002615 \| Low blood pressure \| 1 HP:0001385 \| Congenital hip dysplasia \| 1 HP:0001284 \| Areflexia \| 1 HP:0002608 \| Celiac disease \| 1 HP:0012452 \| Restless legs \| 1 HP:0000097 \| focal glomerulosclerosis \| 1 HP:0100543 \| Cognitive deficits \| 1 HP:0002099 \| Asthma \| 1 HP:0100806 \| Sepsis \| 1 HP:0100660 \| Dyskinesis \| 1 HP:0200119 \| Acute liver inflammation \| 1 HP:0007687 \| Unilateral ptosis \| 1 HP:0002860 \| Squamous cell carcinoma \| 1 HP:0004950 \| Peripheral artery disease \| 1 HP:0001274 \| Absent corpus callosum \| 1 HP:0002385 \| Paraparesis \| 1 HP:0002497 \| Spastic ataxia \| 1 HP:0002960 \| Autoimmune condition \| 1 HP:0003202 \| Neurogenic muscle atrophy, especially in the lower limbs \| 1 HP:0001761 \| Pes cavus \| 1 HP:0001596 \| Hair loss \| 1 HP:0001640 \| Increased heart size \| 1 HP:0000083 \| Renal insufficiency \| 1

Disease ID	844
Disease	polyneuropathy
Manually Symptom	(Waiting for update.)
Text Mined Symptom	UMLS \| Name \| Sentences' Count(Total Symptoms:13) C1136085 \| monoclonal gammopathy \| 13 C0178650 \| gammopathy \| 9 C0085404 \| poems syndrome \| 5 C0030193 \| pain \| 4 C0334044 \| dyscrasia \| 3 C0032131 \| plasmacytoma \| 2 C1136084 \| plasma cell dyscrasia \| 2 C0007286 \| carpal tunnel syndrome \| 2 C1145670 \| respiratory failure \| 2 C0796095 \| c syndrome \| 2 C0423716 \| neuropathic pain \| 2 C0036690 \| sepsis \| 1 C0035258 \| restless legs syndrome \| 1

Manually Genotype(Total Text Mining Genotypes:0)
(Waiting for update.)

All Snps(Total Genotypes:2)
snpId	pubmedId	geneId	geneSymbol	diseaseId	sourceId	sentence	score	Year	geneSymbol_dbSNP	CHROMOSOME	POS	REF	ALT
rs11541794	12000195	7276	TTR	umls:C0152025	BeFree	Transthyretin Thr60Ala Appalachian-type mutation in a Japanese family with familial amyloidotic polyneuropathy.	0.057313961	2002	TTR	18	31593004	A	G
rs28940291	17437620	9927	MFN2	umls:C0152025	BeFree	Mitofusin 2 gene mutation (R94Q) causing severe early-onset axonal polyneuropathy (CMT2A).	0.000814326	2007	MFN2	1	11992660	G	A

GWASdb Annotation(Total Genotypes:0)
(Waiting for update.)

GWASdb Snp Trait(Total Genotypes:0)
(Waiting for update.)

Mapped by lexical matching(Total Items:0)
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Mapped by homologous gene(Total Items:0)
(Waiting for update.)

Chemical(Total Drugs:26)
CUI	ChemicalName	ChemicalID	CasRN	DiseaseName	DiseaseID	DirectEvidence	PubMedIDs
C0152025	acitretin	D017255	55079-83-9	polyneuropathies	MESH:D011115	marker/mechanism	12469004
C0152025	carbimazole	D002231	22232-54-8	polyneuropathies	MESH:D011115	marker/mechanism	6548829
C0152025	chloroquine	D002738	1954/5/7	polyneuropathies	MESH:D011115	marker/mechanism	11245140
C0152025	colchicine	D003078	64-86-8	polyneuropathies	MESH:D011115	marker/mechanism	405656
C0152025	dapsone	D003622	80-08-0	polyneuropathies	MESH:D011115	marker/mechanism	1332194
C0152025	cisplatin	D002945	15663-27-1	polyneuropathies	MESH:D011115	marker/mechanism	10363265
C0152025	doxycycline	D004318	564-25-0	polyneuropathies	MESH:D011115	marker/mechanism	11952888
C0152025	ethambutol	D004977	74-55-5	polyneuropathies	MESH:D011115	marker/mechanism	24897009
C0152025	lindane	D001556	58-89-9	polyneuropathies	MESH:D011115	marker/mechanism	4182533
C0152025	lovastatin	D008148	75330-75-5	polyneuropathies	MESH:D011115	marker/mechanism	12011277
C0152025	mefloquine	D015767	53230-10-7	polyneuropathies	MESH:D011115	marker/mechanism	16242740
C0152025	melphalan	D008558	148-82-3	polyneuropathies	MESH:D011115	therapeutic	3039073
C0152025	methotrexate	D008727	1959/5/2	polyneuropathies	MESH:D011115	marker/mechanism	2131034
C0152025	paclitaxel	D017239	-	polyneuropathies	MESH:D011115	marker/mechanism	11022860
C0152025	phenytoin	D010672	57-41-0	polyneuropathies	MESH:D011115	marker/mechanism	4214527
C0152025	pravastatin	D017035	81093-37-0	polyneuropathies	MESH:D011115	marker/mechanism	12011277
C0152025	pyridoxine	D011736	-	polyneuropathies	MESH:D011115	therapeutic	15838404
C0152025	sirolimus	D020123	53123-88-9	polyneuropathies	MESH:D011115	marker/mechanism	18589148
C0152025	tacrolimus	D016559	109581-93-3	polyneuropathies	MESH:D011115	marker/mechanism	11740402
C0152025	thalidomide	D013792	50-35-1	polyneuropathies	MESH:D011115	marker/mechanism	11951079
C0152025	thiotepa	D013852	52-24-4	polyneuropathies	MESH:D011115	marker/mechanism	2131034
C0152025	vincristine	D014750	-	polyneuropathies	MESH:D011115	marker/mechanism	10217912
C0152025	vinorelbine	C030852	71486-22-1	polyneuropathies	MESH:D011115	marker/mechanism	7577478
C0152025	thiamine	D013831	59-43-8	polyneuropathies	MESH:D011115	marker/mechanism	1017763
C0152025	vitamin e	D014810	1406-18-4	polyneuropathies	MESH:D011115	marker/mechanism	2838210
C0152025	vitamin e	D014810	1406-18-4	polyneuropathies	MESH:D011115	therapeutic	3226394

FDA approved drug and dosage information(Total Drugs:0)
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FDA labeling changes(Total Drugs:0)
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