PedAM

Pediatric Disease Annotations & Medicines


	polyarteritis nodosa

Disease ID	648
Disease	polyarteritis nodosa
Definition	A form of necrotizing non-granulomatous inflammation occurring primarily in medium-sized ARTERIES, often with microaneurysms. It is characterized by muscle, joint, and abdominal pain resulting from arterial infarction and scarring in affected organs. Polyarteritis nodosa with lung involvement is called CHURG-STRAUSS SYNDROME.
Synonym	classic polyarteritis nodosa classical polyarteritis nodosa kussmaul disease nodosa polyarteritis pan - polyarteritis nodosa panarteritis nodosa periarteritis nodosa polyarteritis nodosa (disorder) polyarteritis nodosa [disease/finding] polyarteritis nodosa nos polyarteritis nodosa nos (disorder) polyarteritis nodosa systemic polyarteritis nodosum systemic periarteritis nodosa
Orphanet	ORPHANET:767
DOID	DOID:9810
ICD10	ICD10CM:M30.0
UMLS	C0031036
MeSH	D010488
SNOMED-CT	SNOMEDCT_US_2016_09_01:155441006
Comorbidity	UMLS \| Disease \| Sentences' Count(Total Sentences:43) C0019158 \| hepatitis \| 7 C0042384 \| vasculitis \| 6 C0019163 \| hepatitis b \| 4 C0019196 \| hepatitis c \| 3 C0035078 \| renal failure \| 3 C0021845 \| intestinal perforation \| 2 C0042769 \| virus infection \| 2 C0022660 \| acute renal failure \| 2 C0019163 \| hepatitis b infection \| 1 C0027051 \| myocardial infarct \| 1 C0442874 \| neuropathy \| 1 C0007766 \| intracranial aneurysm \| 1 C0007113 \| rectal cancer \| 1 C0007570 \| celiac disease \| 1 C0031117 \| peripheral neuropathy \| 1 C0025309 \| meningoencephalitis \| 1 C0002726 \| amyloidosis \| 1 C0155626 \| acute myocardial infarction \| 1 C0004153 \| atherosclerosis \| 1 C0040558 \| toxoplasmosis \| 1 C0085642 \| livedo reticularis \| 1 C0026848 \| myopathy \| 1 C1328840 \| autoimmune lymphoproliferative syndrome \| 1 C1565489 \| renal insufficiency \| 1 C0003504 \| aortic regurgitation \| 1 C0021845 \| bowel perforation \| 1 C0010051 \| coronary aneurysm \| 1 C0004096 \| asthma \| 1 C0010414 \| cryptococcus neoformans \| 1 C0027051 \| myocardial infarction \| 1 C0085669 \| acute leukemia \| 1 C0007766 \| cranial aneurysm \| 1 C0032285 \| pneumonia \| 1 C0033975 \| psychosis \| 1 C0020428 \| hyperaldosteronism \| 1 C0027707 \| interstitial nephritis \| 1 C0009319 \| colitis \| 1 C0019196 \| hepatitis c infection \| 1 C0022408 \| arthropathy \| 1 C0010051 \| coronary aneurysms \| 1 C0162529 \| ischemic colitis \| 1 C0031069 \| familial mediterranean fever \| 1 C0241910 \| autoimmune hepatitis \| 1
Curated Gene	Entrez_id \| Symbol \| Resource(Total Genes:1) CECR1 \| 51816 \| CLINVAR
Inferring Gene	(Waiting for update.)
Text Mined Gene	Entrez_id \| Symbol \| Score \| Resource(Total Genes:75) 3385 \| ICAM3 \| DISEASES 350 \| APOH \| DISEASES 4282 \| MIF \| DISEASES 51311 \| TLR8 \| DISEASES 4210 \| MEFV \| DISEASES 973 \| CD79A \| DISEASES 10392 \| NOD1 \| DISEASES 4353 \| MPO \| DISEASES 3458 \| IFNG \| DISEASES 3567 \| IL5 \| DISEASES 5657 \| PRTN3 \| DISEASES 11026 \| LILRA3 \| DISEASES 2006 \| ELN \| DISEASES 47 \| ACLY \| DISEASES 1401 \| CRP \| DISEASES 3569 \| IL6 \| DISEASES 4069 \| LYZ \| DISEASES 51816 \| CECR1 \| DISEASES 27443 \| CECR2 \| DISEASES 671 \| BPI \| DISEASES 22858 \| ICK \| DISEASES 1991 \| ELANE \| DISEASES 5443 \| POMC \| DISEASES 5972 \| REN \| DISEASES 3439 \| IFNA1 \| DISEASES 761 \| CA3 \| DISEASES 3046 \| HBE1 \| DISEASES 60675 \| PROK2 \| DISEASES 213 \| ALB \| DISEASES 3600 \| IL15 \| DISEASES 338323 \| NLRP14 \| DISEASES 1632 \| ECI1 \| DISEASES 133418 \| EMB \| DISEASES 140738 \| TMEM37 \| DISEASES 5068 \| REG3A \| DISEASES 375611 \| SLC26A5 \| DISEASES 3669 \| ISG20 \| DISEASES 56246 \| MRAP \| DISEASES 54205 \| CYCS \| DISEASES 2147 \| F2 \| DISEASES 6670 \| SP3 \| DISEASES 91662 \| NLRP12 \| DISEASES 6014 \| RIT2 \| DISEASES 4496 \| MT1H \| DISEASES 6401 \| SELE \| DISEASES 445329 \| SULT1A4 \| DISEASES 6818 \| SULT1A3 \| DISEASES 5265 \| SERPINA1 \| DISEASES 51155 \| HN1 \| DISEASES 219844 \| HYLS1 \| DISEASES 404552 \| SCGB1D4 \| DISEASES 6525 \| SMTN \| DISEASES 5336 \| PLCG2 \| DISEASES 2157 \| F8 \| DISEASES 4478 \| MSN \| DISEASES 54106 \| TLR9 \| DISEASES 959 \| CD40LG \| DISEASES 6709 \| SPTAN1 \| DISEASES 100 \| ADA \| DISEASES 80312 \| TET1 \| DISEASES 7133 \| TNFRSF1B \| DISEASES 54790 \| TET2 \| DISEASES 3440 \| IFNA2 \| DISEASES 10333 \| TLR6 \| DISEASES 347734 \| SLC35B2 \| DISEASES 1781 \| DYNC1I2 \| DISEASES 3384 \| ICAM2 \| DISEASES 2086 \| ERV3-1 \| DISEASES 26013 \| L3MBTL1 \| DISEASES 7124 \| TNF \| DISEASES 3920 \| LAMP2 \| DISEASES 338376 \| IFNE \| DISEASES 30816 \| ERVW-1 \| DISEASES 51428 \| DDX41 \| DISEASES 22999 \| RIMS1 \| DISEASES
Locus	(Waiting for update.)

Disease ID	648
Disease	polyarteritis nodosa
Integrated Phenotype	(Waiting for update.)
Text Mined Phenotype	HPO \| Name \| Sentences' Count(Total Phenotypes:35) HP:0002617 \| Aneurysmal dilatation \| 8 HP:0012115 \| Liver inflammation \| 7 HP:0002633 \| Vasculitis \| 6 HP:0001945 \| Fever \| 5 HP:0000083 \| Renal insufficiency \| 4 HP:0001919 \| Acute renal failure \| 3 HP:0005200 \| Retroperitoneal fibrosis \| 1 HP:0002829 \| Arthralgias \| 1 HP:0011741 \| Secondary hyperaldosteronism \| 1 HP:0002488 \| Acute leukemias \| 1 HP:0100758 \| Gangrene \| 1 HP:0000709 \| Psychosis \| 1 HP:0002099 \| Asthma \| 1 HP:0003040 \| Arthropathy \| 1 HP:0002583 \| Colitis \| 1 HP:0004944 \| Cerebral artery aneurysm \| 1 HP:0001659 \| Aortic insufficiency \| 1 HP:0003198 \| Myopathic changes \| 1 HP:0001658 \| Myocardial infarction \| 1 HP:0002090 \| Pneumonia \| 1 HP:0001970 \| Interstitial nephritis \| 1 HP:0009027 \| Foot drop \| 1 HP:0030171 \| Perirenal hematoma \| 1 HP:0100762 \| Hemobilia \| 1 HP:0001695 \| Cardiac arrest \| 1 HP:0002621 \| Atherosclerosis \| 1 HP:0001298 \| Encephalopathy \| 1 HP:0009830 \| Peripheral neuritis \| 1 HP:0000859 \| Mineralocorticoid excess \| 1 HP:0001291 \| Cranial nerve disease \| 1 HP:0200029 \| Cutaneous vasculitis \| 1 HP:0002608 \| Celiac disease \| 1 HP:0003613 \| Antiphospholipid antibodies \| 1 HP:0012190 \| T cell lymphoma \| 1 HP:0000965 \| Livedo reticularis \| 1

Disease ID	648
Disease	polyarteritis nodosa
Manually Symptom	(Waiting for update.)
Text Mined Symptom	UMLS \| Name \| Sentences' Count(Total Symptoms:19) C0042384 \| vasculitis \| 6 C0002940 \| aneurysms \| 4 C0002940 \| aneurysm \| 4 C0035078 \| renal failure \| 3 C0021308 \| infarction \| 3 C0022660 \| acute renal failure \| 2 C0021845 \| intestinal perforation \| 2 C0009450 \| infection \| 2 C0018944 \| hematoma \| 1 C0206061 \| interstitial pneumonia \| 1 C0442874 \| neuropathy \| 1 C0017086 \| gangrene \| 1 C0031117 \| peripheral neuropathy \| 1 C0162529 \| ischemic colitis \| 1 C0035085 \| renal infarction \| 1 C0004096 \| asthma \| 1 C1318520 \| necrotizing vasculitis \| 1 C0264972 \| hepatic artery aneurysm \| 1 C0018994 \| haemobilia \| 1

Manually Genotype(Total Text Mining Genotypes:0)
(Waiting for update.)

All Snps(Total Genotypes:8)
snpId	pubmedId	geneId	geneSymbol	diseaseId	sourceId	sentence	score	Year	geneSymbol_dbSNP	CHROMOSOME	POS	REF	ALT
rs148936893	NA	51816	CECR1	umls:C0031036	CLINVAR	NA	0.121085767	NA	CECR1	22	17203564	G	A
rs200930463	NA	51816	CECR1	umls:C0031036	CLINVAR	NA	0.121085767	NA	CECR1	22	17209538	C	A,G
rs202134424	NA	51816	CECR1	umls:C0031036	CLINVAR	NA	0.121085767	NA	CECR1	22	17209539	C	A,G,T
rs376785840	NA	51816	CECR1	umls:C0031036	CLINVAR	NA	0.121085767	NA	CECR1	22	17181904	T	C
rs587777240	NA	51816	CECR1	umls:C0031036	CLINVAR	NA	0.121085767	NA	CECR1	22	17207287	G	T
rs587777241	NA	51816	CECR1	umls:C0031036	CLINVAR	NA	0.121085767	NA	CECR1	22	17207277	G	C
rs587777242	NA	51816	CECR1	umls:C0031036	CLINVAR	NA	0.121085767	NA	CECR1	22	17191773	C	G
rs77563738	NA	51816	CECR1	umls:C0031036	CLINVAR	NA	0.121085767	NA	CECR1	22	17207107	C	G,T

GWASdb Annotation(Total Genotypes:0)
(Waiting for update.)

GWASdb Snp Trait(Total Genotypes:0)
(Waiting for update.)

Mapped by lexical matching(Total Items:0)
(Waiting for update.)

Mapped by homologous gene(Total Items:0)
(Waiting for update.)

Chemical(Total Drugs:12)
CUI	ChemicalName	ChemicalID	CasRN	DiseaseName	DiseaseID	DirectEvidence	PubMedIDs
C0031036	caffeine	D002110	1958/8/2	polyarteritis nodosa	MESH:D010488	marker/mechanism	6118996
C0031036	cyclophosphamide	D003520	50-18-0	polyarteritis nodosa	MESH:D010488	therapeutic	10813312
C0031036	dapsone	D003622	80-08-0	polyarteritis nodosa	MESH:D010488	therapeutic	8698924
C0031036	diltiazem	D004110	42399-41-7	polyarteritis nodosa	MESH:D010488	therapeutic	1971779
C0031036	enalapril	D004656	75847-73-3	polyarteritis nodosa	MESH:D010488	therapeutic	1971779
C0031036	ketorolac	D020910	66635-83-4	polyarteritis nodosa	MESH:D010488	therapeutic	7594371
C0031036	methotrexate	D008727	1959/5/2	polyarteritis nodosa	MESH:D010488	therapeutic	7594371
C0031036	metolazone	D008788	17560-51-9	polyarteritis nodosa	MESH:D010488	marker/mechanism	6126318
C0031036	phenytoin	D010672	57-41-0	polyarteritis nodosa	MESH:D010488	marker/mechanism	6131861
C0031036	propranolol	D011433	525-66-6	polyarteritis nodosa	MESH:D010488	therapeutic	1971779
C0031036	reserpine	D012110	50-55-5	polyarteritis nodosa	MESH:D010488	therapeutic	1971779
C0031036	vidarabine	D014740	5536-17-4	polyarteritis nodosa	MESH:D010488	therapeutic	8097249

FDA approved drug and dosage information(Total Drugs:0)
(Waiting for update.)

FDA labeling changes(Total Drugs:0)
(Waiting for update.)

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