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Pediatric Disease Annotations & Medicines



   pollen allergy
  

Disease ID 640
Disease pollen allergy
Definition
seasonal variety of allergic rhinitis, marked by acute conjunctivitis with lacrimation and itching; regarded as an allergic condition triggered by specific allergens.
Synonym
allergic rhinitides, seasonal
allergic rhinitis caused by pollen
allergic rhinitis caused by pollen (disorder)
allergic rhinitis caused by pollens
allergic rhinitis due to pollen
allergic rhinitis due to pollen (disorder)
allergic rhinitis due to pollens
allergic rhinitis, seasonal
allergies pollen
allergies, pollen
allergy pollen
allergy to pollen
allergy to pollen (disorder)
allergy, pollen
fever hay
fever, hay
hay fever
hay fever - pollens
hayfever
pollen allergies
pollenosis
pollinoses
pollinosis
pollinosis (& allergic rhinitis due to pollens)
rhinitides, seasonal allergic
rhinitis due to pollen
rhinitis, allergic, seasonal
rhinitis, allergic, seasonal [disease/finding]
rhinitis, seasonal allergic
seasonal allergic reaction
seasonal allergic rhinitides
seasonal allergic rhinitis
seasonal allergic rhinitis (disorder)
seasonal allergic rhinitis (disorder) [ambiguous]
seasonal allergic rhinitis [ambiguous]
seasonal allergies
seasonal allergy
seasonal allergy (disorder)
spasmodic rhinorrhea
spasmodic rhinorrhoea
DOID
ICD10
UMLS
C0018621
MeSH
SNOMED-CT
Comorbidity
UMLS | Disease | Sentences' Count(Total Sentences:7)
C0035455  |  rhinitis  |  6
C2607914  |  allergic rhinitis  |  6
C0004096  |  asthma  |  4
C0016470  |  food allergy  |  2
C0018621  |  seasonal allergic rhinitis  |  2
C0011615  |  atopic eczema  |  1
C0013595  |  eczema  |  1
Curated Gene
Entrez_id | Symbol | Resource(Total Genes:10)
CLEC16A  |  23274  |  GWASCAT
SMAD3  |  4088  |  GWASCAT
TLR1  |  7096  |  GWASCAT
IKZF3  |  22806  |  GWASCAT
VAV3  |  10451  |  GWASCAT
XKR6  |  286046  |  GWASCAT
GSDMA  |  284110  |  GWASCAT
CST1  |  1469  |  CTD_human
IL1RL1  |  9173  |  GWASCAT
TNS1  |  7145  |  GWASCAT
Inferring Gene
Entrez_id | Symbol | Resource(Total Genes:23)
3119  |  HLA-DQB1  |  infer
3123  |  HLA-DRB1  |  infer
27  |  ABL2  |  infer
915  |  CD3D  |  infer
23274  |  CLEC16A  |  infer
1437  |  CSF2  |  infer
1493  |  CTLA4  |  infer
1767  |  DNAH5  |  infer
955  |  ENTPD6  |  infer
2060  |  EPS15  |  infer
2737  |  GLI3  |  infer
29851  |  ICOS  |  infer
3596  |  IL13  |  infer
3558  |  IL2  |  infer
3565  |  IL4  |  infer
3567  |  IL5  |  infer
3702  |  ITK  |  infer
652974  |  RPL17P2  |  infer
653737  |  RPL21P119  |  infer
644146  |  RPS14P8  |  infer
6278  |  S100A7  |  infer
91137  |  SLC25A46  |  infer
85480  |  TSLP  |  infer
Text Mined Gene
Entrez_id | Symbol | Score | Resource(Total Genes:109)
51087  |  YBX2  |  DISEASES
3385  |  ICAM3  |  DISEASES
3566  |  IL4R  |  DISEASES
9567  |  GTPBP1  |  DISEASES
638  |  BIK  |  DISEASES
3560  |  IL2RB  |  DISEASES
6554  |  SLC10A1  |  DISEASES
10423  |  CDIPT  |  DISEASES
973  |  CD79A  |  DISEASES
10282  |  BET1  |  DISEASES
969  |  CD69  |  DISEASES
3565  |  IL4  |  DISEASES
3567  |  IL5  |  DISEASES
9173  |  IL1RL1  |  DISEASES
5273  |  SERPINB10  |  DISEASES
3598  |  IL13RA2  |  DISEASES
6626  |  SNRPA  |  DISEASES
6351  |  CCL4  |  DISEASES
1215  |  CMA1  |  DISEASES
967  |  CD63  |  DISEASES
80896  |  NPL  |  DISEASES
27348  |  TOR1B  |  DISEASES
5082  |  PDCL  |  DISEASES
7097  |  TLR2  |  DISEASES
4016  |  LOXL1  |  DISEASES
7011  |  TEP1  |  DISEASES
55717  |  WDR11  |  DISEASES
27143  |  PALD1  |  DISEASES
975  |  CD81  |  DISEASES
941  |  CD80  |  DISEASES
3383  |  ICAM1  |  DISEASES
2162  |  F13A1  |  DISEASES
939  |  CD27  |  DISEASES
9611  |  NCOR1  |  DISEASES
9775  |  EIF4A3  |  DISEASES
2206  |  MS4A2  |  DISEASES
7292  |  TNFSF4  |  DISEASES
11309  |  SLCO2B1  |  DISEASES
6352  |  CCL5  |  DISEASES
29765  |  TMOD4  |  DISEASES
152185  |  SPICE1  |  DISEASES
213  |  ALB  |  DISEASES
3562  |  IL3  |  DISEASES
5267  |  SERPINA4  |  DISEASES
94274  |  PPP1R14A  |  DISEASES
6037  |  RNASE3  |  DISEASES
10879  |  SMR3B  |  DISEASES
3603  |  IL16  |  DISEASES
6036  |  RNASE2  |  DISEASES
375611  |  SLC26A5  |  DISEASES
3596  |  IL13  |  DISEASES
9482  |  STX8  |  DISEASES
8763  |  CD164  |  DISEASES
1657  |  DMXL1  |  DISEASES
9092  |  SART1  |  DISEASES
23166  |  STAB1  |  DISEASES
80199  |  FUZ  |  DISEASES
1831  |  TSC22D3  |  DISEASES
4161  |  MC5R  |  DISEASES
6470  |  SHMT1  |  DISEASES
3563  |  IL3RA  |  DISEASES
8784  |  TNFRSF18  |  DISEASES
10871  |  CD300C  |  DISEASES
942  |  CD86  |  DISEASES
54101  |  RIPK4  |  DISEASES
11251  |  PTGDR2  |  DISEASES
2289  |  FKBP5  |  DISEASES
84419  |  C15orf48  |  DISEASES
9588  |  PRDX6  |  DISEASES
5132  |  PDC  |  DISEASES
2224  |  FDPS  |  DISEASES
5169  |  ENPP3  |  DISEASES
6942  |  TCF20  |  DISEASES
51150  |  SDF4  |  DISEASES
3123  |  HLA-DRB1  |  DISEASES
11314  |  CD300A  |  DISEASES
3135  |  HLA-G  |  DISEASES
54106  |  TLR9  |  DISEASES
128239  |  IQGAP3  |  DISEASES
58505  |  OSTC  |  DISEASES
1847  |  DUSP5  |  DISEASES
959  |  CD40LG  |  DISEASES
6342  |  SCP2  |  DISEASES
3597  |  IL13RA1  |  DISEASES
6789  |  STK4  |  DISEASES
27095  |  TRAPPC3  |  DISEASES
7185  |  TRAF1  |  DISEASES
712  |  C1QA  |  DISEASES
3127  |  HLA-DRB5  |  DISEASES
50943  |  FOXP3  |  DISEASES
160897  |  GPR180  |  DISEASES
2512  |  FTL  |  DISEASES
2189  |  FANCG  |  DISEASES
5212  |  VIT  |  DISEASES
2874  |  GPS2  |  DISEASES
238  |  ALK  |  DISEASES
1439  |  CSF2RB  |  DISEASES
57703  |  CWC22  |  DISEASES
9564  |  BCAR1  |  DISEASES
3586  |  IL10  |  DISEASES
27333  |  GOLIM4  |  DISEASES
51428  |  DDX41  |  DISEASES
3620  |  IDO1  |  DISEASES
83695  |  RHNO1  |  DISEASES
1232  |  CCR3  |  DISEASES
11331  |  PHB2  |  DISEASES
387521  |  TMEM189  |  DISEASES
23186  |  RCOR1  |  DISEASES
100124700  |  HOTAIR  |  DISEASES
Locus(Waiting for update.)
Disease ID 640
Disease pollen allergy
Integrated Phenotype(Waiting for update.)
Text Mined Phenotype
HPO | Name | Sentences' Count(Total Phenotypes:5)
HP:0012384  |  Nasal inflammation  |  6
HP:0012393  |  Allergy  |  6
HP:0003193  |  Allergic rhinitis  |  6
HP:0002099  |  Asthma  |  4
HP:0000964  |  Eczema  |  1
Disease ID 640
Disease pollen allergy
Manually Symptom(Waiting for update.)
Text Mined Symptom
UMLS | Name | Sentences' Count(Total Symptoms:2)
C0035455  |  rhinitis  |  6
C0004096  |  asthma  |  4
Manually Genotype(Total Text Mining Genotypes:0)
(Waiting for update.)
All Snps(Total Genotypes:37)
snpId pubmedId geneId geneSymbol diseaseId sourceId sentence score Year geneSymbol_dbSNP CHROMOSOME POS REF ALT
rs10197862243880139173IL1RL1umls:C0018621GWASCATGenome-wide association analysis identifies 11 risk variants associated with the asthma with hay fever phenotype.0.122013IL1RL12102350089AG
rs104457322036096955ENTPD6umls:C0018621GAD[This relatively large meta-analysis of GWASs identified few loci associated with AR and grass sensitization. No birth order interaction was identified in the current analyses.]0.0023670322011ENTPD62025226018AG
rs124503232438801322806IKZF3umls:C0018621GWASCATGenome-wide association analysis identifies 11 risk variants associated with the asthma with hay fever phenotype.0.122013IKZF31739816455GT
rs13251952203609627ABL2umls:C0018621GAD[This relatively large meta-analysis of GWASs identified few loci associated with AR and grass sensitization. No birth order interaction was identified in the current analyses.]0.0023670322011ABL21179102621GA
rs16997517210715413598IL13RA2umls:C0018621BeFreeOf 60 tagging single-nucleotide polymorphisms covering eight genes (CSF2, IL3, IL4, IL13, CSF2RB, IL4R, IL13RA1, IL13RA2), several were related to pollen allergies among controls: IL4R rs3024647 (dominant OR: 1.5; 95% CI: 1.0-2.3; P = 0.04), CSF2RB rs16997517 (dominant OR: 2.2; 95% CI: 1.0-4.7; P = 0.04), and IL13 rs1800925 (per-allele OR: 1.7; 95% CI: 1.3-2.4; P = 0.0007).0.0002714422011CSF2RB2236937894CT
rs16997517210715413596IL13umls:C0018621BeFreeOf 60 tagging single-nucleotide polymorphisms covering eight genes (CSF2, IL3, IL4, IL13, CSF2RB, IL4R, IL13RA1, IL13RA2), several were related to pollen allergies among controls: IL4R rs3024647 (dominant OR: 1.5; 95% CI: 1.0-2.3; P = 0.04), CSF2RB rs16997517 (dominant OR: 2.2; 95% CI: 1.0-4.7; P = 0.04), and IL13 rs1800925 (per-allele OR: 1.7; 95% CI: 1.3-2.4; P = 0.0007).0.007643982011CSF2RB2236937894CT
rs16997517210715411439CSF2RBumls:C0018621BeFreeCSF2RB rs16997517 was directly related to pollen allergies in controls and to reduced SCC risk.0.0002714422011CSF2RB2236937894CT
rs16997517210715413566IL4Rumls:C0018621BeFreeOf 60 tagging single-nucleotide polymorphisms covering eight genes (CSF2, IL3, IL4, IL13, CSF2RB, IL4R, IL13RA1, IL13RA2), several were related to pollen allergies among controls: IL4R rs3024647 (dominant OR: 1.5; 95% CI: 1.0-2.3; P = 0.04), CSF2RB rs16997517 (dominant OR: 2.2; 95% CI: 1.0-4.7; P = 0.04), and IL13 rs1800925 (per-allele OR: 1.7; 95% CI: 1.3-2.4; P = 0.0007).0.0031813582011CSF2RB2236937894CT
rs17294280243880134088SMAD3umls:C0018621GWASCATGenome-wide association analysis identifies 11 risk variants associated with the asthma with hay fever phenotype.0.122013SMAD31567175947AG
rs175135032203609691137SLC25A46umls:C0018621GAD[This relatively large meta-analysis of GWASs identified few loci associated with AR and grass sensitization. No birth order interaction was identified in the current analyses.]0.0023670322011NA5110810746CG
rs1800925210715413598IL13RA2umls:C0018621BeFreeOf 60 tagging single-nucleotide polymorphisms covering eight genes (CSF2, IL3, IL4, IL13, CSF2RB, IL4R, IL13RA1, IL13RA2), several were related to pollen allergies among controls: IL4R rs3024647 (dominant OR: 1.5; 95% CI: 1.0-2.3; P = 0.04), CSF2RB rs16997517 (dominant OR: 2.2; 95% CI: 1.0-4.7; P = 0.04), and IL13 rs1800925 (per-allele OR: 1.7; 95% CI: 1.3-2.4; P = 0.0007).0.0002714422011IL13;LOC1019277615132657117CT
rs1800925210715413566IL4Rumls:C0018621BeFreeOf 60 tagging single-nucleotide polymorphisms covering eight genes (CSF2, IL3, IL4, IL13, CSF2RB, IL4R, IL13RA1, IL13RA2), several were related to pollen allergies among controls: IL4R rs3024647 (dominant OR: 1.5; 95% CI: 1.0-2.3; P = 0.04), CSF2RB rs16997517 (dominant OR: 2.2; 95% CI: 1.0-4.7; P = 0.04), and IL13 rs1800925 (per-allele OR: 1.7; 95% CI: 1.3-2.4; P = 0.0007).0.0031813582011IL13;LOC1019277615132657117CT
rs1800925210715413596IL13umls:C0018621BeFreeOf 60 tagging single-nucleotide polymorphisms covering eight genes (CSF2, IL3, IL4, IL13, CSF2RB, IL4R, IL13RA1, IL13RA2), several were related to pollen allergies among controls: IL4R rs3024647 (dominant OR: 1.5; 95% CI: 1.0-2.3; P = 0.04), CSF2RB rs16997517 (dominant OR: 2.2; 95% CI: 1.0-4.7; P = 0.04), and IL13 rs1800925 (per-allele OR: 1.7; 95% CI: 1.3-2.4; P = 0.0007).0.007643982011IL13;LOC1019277615132657117CT
rs18986712203609685480TSLPumls:C0018621GAD[This relatively large meta-analysis of GWASs identified few loci associated with AR and grass sensitization. No birth order interaction was identified in the current analyses.]0.0026384742011TSLP5111072304CT
rs2069772220360963558IL2umls:C0018621GAD[This relatively large meta-analysis of GWASs identified few loci associated with AR and grass sensitization. No birth order interaction was identified in the current analyses.]0.0026384742011IL24122451978TC
rs2155219220360962615LRRC32umls:C0018621BeFreeVariants in a locus near chromosome 11 open reading frame 30 (C11orf30) and leucine-rich repeat containing 32 (LRRC32), which was previously associated with atopic dermatitis and eczema, were also strongly associated with both phenotypes (rs2155219; P(grass) = 9.4 × 10(-9); P(AR) = 3.8 × 10(-8)).0.0005428842011NA1176588150GT
rs21552192203609656946C11orf30umls:C0018621GAD[Variants in a locus near chromosome 11 open reading frame 30 (C11orf30) and leucine-rich repeat containing 32 (LRRC32), which was previously associated with atopic dermatitis and eczema, were also strongly associated with both phenotypes (rs2155219; P(grass)A = 9.4 A 10(-9); P(AR)A = 3.8 A 10(-8)).]0.0026384742011NA1176588150GT
rs21552192203609656946C11orf30umls:C0018621BeFreeVariants in a locus near chromosome 11 open reading frame 30 (C11orf30) and leucine-rich repeat containing 32 (LRRC32), which was previously associated with atopic dermatitis and eczema, were also strongly associated with both phenotypes (rs2155219; P(grass) = 9.4 × 10(-9); P(AR) = 3.8 × 10(-8)).0.0026384742011NA1176588150GT
rs3024647210715413566IL4Rumls:C0018621BeFreeOf 60 tagging single-nucleotide polymorphisms covering eight genes (CSF2, IL3, IL4, IL13, CSF2RB, IL4R, IL13RA1, IL13RA2), several were related to pollen allergies among controls: IL4R rs3024647 (dominant OR: 1.5; 95% CI: 1.0-2.3; P = 0.04), CSF2RB rs16997517 (dominant OR: 2.2; 95% CI: 1.0-4.7; P = 0.04), and IL13 rs1800925 (per-allele OR: 1.7; 95% CI: 1.3-2.4; P = 0.0007).0.0031813582011IL4R1627356651GA
rs3024647210715413598IL13RA2umls:C0018621BeFreeOf 60 tagging single-nucleotide polymorphisms covering eight genes (CSF2, IL3, IL4, IL13, CSF2RB, IL4R, IL13RA1, IL13RA2), several were related to pollen allergies among controls: IL4R rs3024647 (dominant OR: 1.5; 95% CI: 1.0-2.3; P = 0.04), CSF2RB rs16997517 (dominant OR: 2.2; 95% CI: 1.0-4.7; P = 0.04), and IL13 rs1800925 (per-allele OR: 1.7; 95% CI: 1.3-2.4; P = 0.0007).0.0002714422011IL4R1627356651GA
rs3024647210715413596IL13umls:C0018621BeFreeOf 60 tagging single-nucleotide polymorphisms covering eight genes (CSF2, IL3, IL4, IL13, CSF2RB, IL4R, IL13RA1, IL13RA2), several were related to pollen allergies among controls: IL4R rs3024647 (dominant OR: 1.5; 95% CI: 1.0-2.3; P = 0.04), CSF2RB rs16997517 (dominant OR: 2.2; 95% CI: 1.0-4.7; P = 0.04), and IL13 rs1800925 (per-allele OR: 1.7; 95% CI: 1.3-2.4; P = 0.0007).0.007643982011IL4R1627356651GA
rs4724100220360962737GLI3umls:C0018621GAD[This relatively large meta-analysis of GWASs identified few loci associated with AR and grass sensitization. No birth order interaction was identified in the current analyses.]0.0023670322011GLI3742225080TC
rs4833095243880137096TLR1umls:C0018621GWASCATGenome-wide association analysis identifies 11 risk variants associated with the asthma with hay fever phenotype.0.1223670322013TLR1438798089TC
rs4986790211038857099TLR4umls:C0018621BeFreeOur objective was to determine the frequency of TNF-alpha -238, -308 G/A promoter and TLR-4 299 D/G and 399 T/I polymorphisms in healthy population and in patients with seasonal allergic rhinitis, and to examine its influences on serum TNF-alpha, TNF receptor-1, Fas, Fas-ligand, IgE levels and on clinical symptoms.0.0029099162011TLR49117713024AG
rs4986791211038857099TLR4umls:C0018621BeFreeOur objective was to determine the frequency of TNF-alpha -238, -308 G/A promoter and TLR-4 299 D/G and 399 T/I polymorphisms in healthy population and in patients with seasonal allergic rhinitis, and to examine its influences on serum TNF-alpha, TNF receptor-1, Fas, Fas-ligand, IgE levels and on clinical symptoms.0.0029099162011TLR49117713324CT
rs620263762438801323274CLEC16Aumls:C0018621GWASCATAt genome-wide significance, we identified 11 independent variants associated with the risk of having asthma with hay fever, including 2 associations reaching this level of significance with allergic disease for the first time: ZBTB10 (rs7009110; odds ratio [OR], 1.14; P = 4 × 10(-9)) and CLEC16A (rs62026376; OR, 1.17; P = 1 × 10(-8)).0.1226384742013CLEC16A1611134855CT
rs620263762438801323274CLEC16Aumls:C0018621BeFreeAt genome-wide significance, we identified 11 independent variants associated with the risk of having asthma with hay fever, including 2 associations reaching this level of significance with allergic disease for the first time: ZBTB10 (rs7009110; odds ratio [OR], 1.14; P = 4 × 10(-9)) and CLEC16A (rs62026376; OR, 1.17; P = 1 × 10(-8)).0.1226384742013CLEC16A1611134855CT
rs6554809220360961767DNAH5umls:C0018621GAD[This relatively large meta-analysis of GWASs identified few loci associated with AR and grass sensitization. No birth order interaction was identified in the current analyses.]0.0023670322011DNAH5513740867CT
rs6673480220360962060EPS15umls:C0018621GAD[This relatively large meta-analysis of GWASs identified few loci associated with AR and grass sensitization. No birth order interaction was identified in the current analyses.]0.0023670322011EPS15151393570CT
rs698275124388013286046XKR6umls:C0018621GWASCATGenome-wide association analysis identifies 11 risk variants associated with the asthma with hay fever phenotype.0.122013XKR6810955964CG
rs70091102438801323274CLEC16Aumls:C0018621BeFreeAt genome-wide significance, we identified 11 independent variants associated with the risk of having asthma with hay fever, including 2 associations reaching this level of significance with allergic disease for the first time: ZBTB10 (rs7009110; odds ratio [OR], 1.14; P = 4 × 10(-9)) and CLEC16A (rs62026376; OR, 1.17; P = 1 × 10(-8)).0.1226384742013NA880379644TC
rs721293824388013284110GSDMAumls:C0018621GWASCATA variant near LRRC32 was a stronger risk factor for hay fever than for asthma, whereas the reverse was observed for variants in/near GSDMA and TSLP.0.122013GSDMA1739966427GA,T
rs75216812438801310451VAV3umls:C0018621GWASCATGenome-wide association analysis identifies 11 risk variants associated with the asthma with hay fever phenotype.0.122013VAV31107779913GA
rs76043829243880137145TNS1umls:C0018621GWASCATSingle nucleotide polymorphisms with suggestive evidence for association with asthma with hay fever risk included rs41295115 near IL2RA (OR, 1.28; P = 5 × 10(-7)) and rs76043829 in TNS1 (OR, 1.23; P = 2 × 10(-6)).0.122013TNS12217812863GA
rs761745622036096348808NPHP3-AS1umls:C0018621GAD[This relatively large meta-analysis of GWASs identified few loci associated with AR and grass sensitization. No birth order interaction was identified in the current analyses.]0.0023670322011NA3133009059GA
rs7775228220360963119HLA-DQB1umls:C0018621GAD[This relatively large meta-analysis of GWASs identified few loci associated with AR and grass sensitization. No birth order interaction was identified in the current analyses.]0.0050055062011NA632690302TC
rs8878642203609623274CLEC16Aumls:C0018621GAD[This relatively large meta-analysis of GWASs identified few loci associated with AR and grass sensitization. No birth order interaction was identified in the current analyses.]0.1226384742011CLEC16A1611065028GC,A
GWASdb Annotation(Total Genotypes:0)
(Waiting for update.)
GWASdb Snp Trait(Total Genotypes:0)
(Waiting for update.)
Mapped by lexical matching(Total Items:0)
(Waiting for update.)
Mapped by homologous gene(Total Items:0)
(Waiting for update.)
Chemical(Total Drugs:3)
CUI ChemicalName ChemicalID CasRN DiseaseName DiseaseID DirectEvidence PubMedIDs
C0018621cetirizineD01733283881-51-0rhinitis, allergic, seasonalMESH:D006255therapeutic11034010
C0018621loratadineD01733679794-75-5rhinitis, allergic, seasonalMESH:D006255therapeutic10400480
C0018621terfenadineD01659350679-08-8rhinitis, allergic, seasonalMESH:D006255therapeutic1644069
FDA approved drug and dosage information(Total Drugs:0)
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FDA labeling changes(Total Drugs:0)
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