PedAM

Pediatric Disease Annotations & Medicines


	poliomyelitis

Disease ID	305
Disease	poliomyelitis
Definition	An acute infectious disease of humans, particularly children, caused by any of three serotypes of human poliovirus (POLIOVIRUS). Usually the infection is limited to the gastrointestinal tract and nasopharynx, and is often asymptomatic. The central nervous system, primarily the spinal cord, may be affected, leading to rapidly progressive paralysis, coarse FASCICULATION and hyporeflexia. Motor neurons are primarily affected. Encephalitis may also occur. The virus replicates in the nervous system, and may cause significant neuronal loss, most notably in the spinal cord. A rare related condition, nonpoliovirus poliomyelitis, may result from infections with nonpoliovirus enteroviruses. (From Adams et al., Principles of Neurology, 6th ed, pp764-5)
Synonym	[x]acute poliomyelitis, unspecified [x]acute poliomyelitis, unspecified (disorder) acute polio acute poliomyelitis acute poliomyelitis (disorder) acute poliomyelitis nos acute poliomyelitis nos (disorder) acute poliomyelitis, epidemic acute poliomyelitis, nos acute poliomyelitis, unspecified epidemic acute poliomyelitis epidemic acute poliomyelitis (disorder) epidemic acute poliomyelitis, nos heine-medin disease pm - poliomyelitis polia polio poliomyelitis (disorder) poliomyelitis [disease/finding] poliomyelitis, acute poliomyelitis, epidemic acute poliomyelitis, nos polios
Orphanet	ORPHANET:2912
DOID	DOID:4953
ICD10	ICD10CM:A80.9
UMLS	C0032371
MeSH	D011051
SNOMED-CT	SNOMEDCT_US_2016_09_01:398256009;SNOMEDCT_US_2016_09_01:398102009
Comorbidity	UMLS \| Disease \| Sentences' Count(Total Sentences:22) C0740441 \| acute diarrhea \| 3 C0036439 \| scoliosis \| 3 C0011991 \| diarrhea \| 2 C0032285 \| pneumoniae \| 2 C0025290 \| aseptic meningitis \| 2 C0039614 \| tetanus \| 2 C0025289 \| meningitis \| 2 C0014877 \| esotropia \| 1 C0023418 \| leukemia \| 1 C0017160 \| gastroenteritis \| 1 C0029456 \| osteoporosis \| 1 C0027059 \| myocarditis \| 1 C0032371 \| polio \| 1 C0037317 \| sleep disturbance \| 1 C0024530 \| malaria \| 1 C0037317 \| sleep disturbances \| 1 C0035258 \| restless legs syndrome \| 1 C0011570 \| depression \| 1 C0020538 \| hypertension \| 1 C1145670 \| respiratory failure \| 1 C0004096 \| asthma \| 1 C0026846 \| muscle atrophy \| 1
Curated Gene	Entrez_id \| Symbol \| Resource(Total Genes:1) PVR \| 5817 \| CTD_human
Inferring Gene	Entrez_id \| Symbol \| Resource(Total Genes:3) 2212 \| FCGR2A \| infer 2214 \| FCGR3A \| infer 2215 \| FCGR3B \| infer
Text Mined Gene	Entrez_id \| Symbol \| Score \| Resource(Total Genes:121) 65078 \| RTN4R \| DISEASES 55359 \| STYK1 \| DISEASES 55808 \| ST6GALNAC1 \| DISEASES 771 \| CA12 \| DISEASES 10278 \| EFS \| DISEASES 973 \| CD79A \| DISEASES 23064 \| SETX \| DISEASES 3485 \| IGFBP2 \| DISEASES 1509 \| CTSD \| DISEASES 1846 \| DUSP4 \| DISEASES 23435 \| TARDBP \| DISEASES 79441 \| HAUS3 \| DISEASES 56269 \| IRGC \| DISEASES 8189 \| SYMPK \| DISEASES 79132 \| DHX58 \| DISEASES 10752 \| CHL1 \| DISEASES 269 \| AMHR2 \| DISEASES 9038 \| TAAR5 \| DISEASES 80326 \| WNT10A \| DISEASES 640 \| BLK \| DISEASES 2995 \| GYPC \| DISEASES 10017 \| BCL2L10 \| DISEASES 64131 \| XYLT1 \| DISEASES 11019 \| LIAS \| DISEASES 6521 \| SLC4A1 \| DISEASES 25939 \| SAMHD1 \| DISEASES 6855 \| SYP \| DISEASES 3977 \| LIFR \| DISEASES 64135 \| IFIH1 \| DISEASES 7301 \| TYRO3 \| DISEASES 29899 \| GPSM2 \| DISEASES 4811 \| NID1 \| DISEASES 57679 \| ALS2 \| DISEASES 5443 \| POMC \| DISEASES 2121 \| EVC \| DISEASES 64083 \| GOLPH3 \| DISEASES 51608 \| GET4 \| DISEASES 5286 \| PIK3C2A \| DISEASES 3263 \| HPX \| DISEASES 347902 \| AMIGO2 \| DISEASES 7168 \| TPM1 \| DISEASES 5298 \| PI4KB \| DISEASES 148327 \| CREB3L4 \| DISEASES 3484 \| IGFBP1 \| DISEASES 10750 \| GRAP \| DISEASES 23474 \| ETHE1 \| DISEASES 4634 \| MYL3 \| DISEASES 178 \| AGL \| DISEASES 4131 \| MAP1B \| DISEASES 115825 \| WDFY2 \| DISEASES 382 \| ARF6 \| DISEASES 89832 \| CHRFAM7A \| DISEASES 1632 \| ECI1 \| DISEASES 79058 \| ASPSCR1 \| DISEASES 3479 \| IGF1 \| DISEASES 5093 \| PCBP1 \| DISEASES 5066 \| PAM \| DISEASES 695 \| BTK \| DISEASES 5653 \| KLK6 \| DISEASES 27165 \| GLS2 \| DISEASES 11322 \| TMC6 \| DISEASES 53347 \| UBASH3A \| DISEASES 56776 \| FMN2 \| DISEASES 3183 \| HNRNPC \| DISEASES 25915 \| NDUFAF3 \| DISEASES 29110 \| TBK1 \| DISEASES 4600 \| MX2 \| DISEASES 23008 \| KLHDC10 \| DISEASES 22821 \| RASA3 \| DISEASES 9138 \| ARHGEF1 \| DISEASES 10488 \| CREB3 \| DISEASES 378884 \| NHLRC1 \| DISEASES 51297 \| BPIFA1 \| DISEASES 79971 \| WLS \| DISEASES 27030 \| MLH3 \| DISEASES 26136 \| TES \| DISEASES 2996 \| GYPE \| DISEASES 9652 \| TTC37 \| DISEASES 7415 \| VCP \| DISEASES 55028 \| C17orf80 \| DISEASES 617 \| BCS1L \| DISEASES 5094 \| PCBP2 \| DISEASES 2987 \| GUK1 \| DISEASES 64746 \| ACBD3 \| DISEASES 1805 \| DPT \| DISEASES 9191 \| DEDD \| DISEASES 55974 \| SLC50A1 \| DISEASES 103 \| ADAR \| DISEASES 51175 \| TUBE1 \| DISEASES 4893 \| NRAS \| DISEASES 11218 \| DDX20 \| DISEASES 2316 \| FLNA \| DISEASES 4923 \| NTSR1 \| DISEASES 959 \| CD40LG \| DISEASES 6005 \| RHAG \| DISEASES 1907 \| EDN2 \| DISEASES 55315 \| SLC29A3 \| DISEASES 65108 \| MARCKSL1 \| DISEASES 2550 \| GABBR1 \| DISEASES 11332 \| ACOT7 \| DISEASES 51567 \| TDP2 \| DISEASES 3980 \| LIG3 \| DISEASES 23586 \| DDX58 \| DISEASES 5799 \| PTPRN2 \| DISEASES 23426 \| GRIP1 \| DISEASES 8570 \| KHSRP \| DISEASES 55636 \| CHD7 \| DISEASES 720 \| C4A \| DISEASES 7124 \| TNF \| DISEASES 57506 \| MAVS \| DISEASES 5817 \| PVR \| DISEASES 1139 \| CHRNA7 \| DISEASES 30816 \| ERVW-1 \| DISEASES 2994 \| GYPB \| DISEASES 270 \| AMPD1 \| DISEASES 930 \| CD19 \| DISEASES 146227 \| BEAN1 \| DISEASES 4637 \| MYL6 \| DISEASES 820 \| CAMP \| DISEASES 54938 \| SARS2 \| DISEASES 102723508 \| KANTR \| DISEASES
Locus	(Waiting for update.)

Disease ID	305
Disease	poliomyelitis
Integrated Phenotype	(Waiting for update.)
Text Mined Phenotype	HPO \| Name \| Sentences' Count(Total Phenotypes:23) HP:0003470 \| Inability to move \| 12 HP:0012378 \| Fatigue \| 6 HP:0012531 \| Pain \| 5 HP:0002650 \| Scoliosis \| 3 HP:0001297 \| Cerebral vascular events \| 2 HP:0002014 \| Diarrhea \| 2 HP:0001287 \| Meningitis \| 2 HP:0002099 \| Asthma \| 1 HP:0001909 \| Leukemia \| 1 HP:0012819 \| Myocarditis \| 1 HP:0000565 \| Inward turning of one or both eyes \| 1 HP:0002527 \| Falls \| 1 HP:0002015 \| Swallowing difficulty \| 1 HP:0003202 \| Neurogenic muscle atrophy, especially in the lower limbs \| 1 HP:0000716 \| Depression \| 1 HP:0040078 \| Axonal degeneration \| 1 HP:0000822 \| Hypertension \| 1 HP:0000939 \| Osteoporosis \| 1 HP:0002878 \| Respiratory failure \| 1 HP:0002360 \| Sleep disturbance \| 1 HP:0001618 \| Dysphonia \| 1 HP:0002385 \| Paraparesis \| 1 HP:0001324 \| Muscular weakness \| 1

Disease ID	305
Disease	poliomyelitis
Manually Symptom	UMLS \| Name(Total Manually Symptoms:65) C2598155 \| pain C2364133 \| infection C2364118 \| weakness C2364103 \| sensory deficit C2364051 \| fatigue C2364050 \| hypothermia C1971021 \| potassium depletion C1963138 \| hypertension C1963064 \| anxiety C1962971 \| myocarditis C1801950 \| g syndrome C1510420 \| cavities C1456822 \| lameness C1330961 \| acidity C1145670 \| respiratory failure C1145628 \| disorders of the autonomic nervous system C0877389 \| gonarthrosis C0876973 \| pulmonary infections C0869523 \| carditis C0865850 \| acute respiratory insufficiency C0700208 \| scoliosis C0700201 \| sleep disturbance C0600033 \| kyphoscoliosis C0522224 \| palsy C0451641 \| urinary lithiasis C0278134 \| sensory loss C0270814 \| spastic syndrome C0262471 \| ent problem C0231796 \| respiratory abnormalities C0221163 \| motor disorders C0205721 \| hospital infections C0205721 \| hospital infection C0155288 \| papilledema C0154703 \| upper extremity paralysis C0151311 \| cranial nerve paralysis C0085620 \| flaccid paralysis C0042749 \| viremia C0041834 \| erythema C0037763 \| spasm C0037763 \| muscle spasms C0037763 \| muscle spasm C0035229 \| respiratory insufficiency C0035204 \| respiratory disorders C0035204 \| respiration disorders C0034372 \| quadriplegia C0034065 \| pulmonary embolism C0030824 \| allergy to penicillin C0030442 \| bulbar paralysis C0027709 \| nephrocalcinosis C0027122 \| myositis ossificans C0026650 \| movement disorders C0022408 \| arthrosis C0020701 \| hysteria C0020538 \| high blood pressure C0019087 \| hemorrhagic diathesis C0018524 \| hallucinations C0015469 \| facial paralysis C0015469 \| facial nerve paralysis C0014070 \| encephalomyelitis C0014059 \| acute disseminated encephalomyelitis C0014038 \| encephalitis C0013949 \| embryopathy C0013404 \| breathing difficulties C0004044 \| asphyxia C0003881 \| arthrodesis
Text Mined Symptom	UMLS \| Name \| Sentences' Count(Total Symptoms:11) C0015672 \| fatigue \| 6 C0085620 \| flaccid paralysis \| 6 C0036439 \| scoliosis \| 3 C0009450 \| infection \| 3 C0021311 \| infections \| 1 C0011168 \| dysphagia \| 1 C0004093 \| weakness \| 1 C0037317 \| sleep disturbance \| 1 C0231443 \| musculoskeletal symptoms \| 1 C1145670 \| respiratory failure \| 1 C0030193 \| pain \| 1

Manually Genotype(Total Text Mining Genotypes:0)
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GWASdb Annotation(Total Genotypes:0)
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GWASdb Snp Trait(Total Genotypes:0)
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Mapped by lexical matching(Total Items:0)
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Mapped by homologous gene(Total Items:0)
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Chemical(Total Drugs:0)
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FDA approved drug and dosage information(Total Drugs:0)
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FDA labeling changes(Total Drugs:0)
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