PedAM

Pediatric Disease Annotations & Medicines


	pneumocystosis

Disease ID	446
Disease	pneumocystosis
Definition	pulmonary disease in humans occurring in immunodeficient or malnourished patients or infants, characterized by dyspnea, tachypnea, and hypoxemia; Pneumocystis pneumonia is a frequent opportunistic infection in AIDS; also found in other mammals where it is caused by related species of Pneumocystis.
Synonym	interstitial plasma cell pneumonia pcp - pneumocystis carinii pneumonia pcp - pneumocystis pneumonia pjp pneumocystis carinii pneumonia pneumocystis carinii pneumonia (disorder) pneumocystis carinii pneumonia (pcp) pneumocystis jiroveci pneumonia pneumocystis jirovecii pneumonia pneumocystis pneumonia pneumocystis pneumonias pneumocystoses pneumocystosis (disorder) pneumocystosis jiroveci pneumonia pneumocystosis jiroveci pneumonia (disorder) pneumocystosis jirovecii pneumonia pneumocystosis jirovecii pneumonia (disorder) pneumocystosis pneumonia pneumocytosis pneumonia due to pneumocystis carinii pneumonia, interstitial plasma cell pneumonia, pneumocystis pneumonia, pneumocystis [disease/finding] pneumonia, pneumocystis carinii pneumonias, pneumocystis pneumonias, pneumocystis carinii pulmonary pneumocystosis pulmonary pneumocystosis (disorder)
Orphanet	ORPHANET:723
DOID	DOID:11339
ICD10	ICD10CM:B59
UMLS	C1535939
MeSH	D011020
SNOMED-CT	SNOMEDCT_US_2016_09_01:415125002;SNOMEDCT_US_2016_09_01:88860002
Comorbidity	UMLS \| Disease \| Sentences' Count(Total Sentences:1) C0010346 \| crohn's disease \| 1
Curated Gene	(Waiting for update.)
Inferring Gene	(Waiting for update.)
Text Mined Gene	Entrez_id \| Symbol \| Score \| Resource(Total Genes:148) 920 \| CD4 \| DISEASES 7132 \| TNFRSF1A \| DISEASES 1725 \| DHPS \| DISEASES 64841 \| GNPNAT1 \| DISEASES 973 \| CD79A \| DISEASES 1440 \| CSF3 \| DISEASES 7448 \| VTN \| DISEASES 3558 \| IL2 \| DISEASES 6688 \| SPI1 \| DISEASES 3458 \| IFNG \| DISEASES 55907 \| CMAS \| DISEASES 3565 \| IL4 \| DISEASES 3567 \| IL5 \| DISEASES 4953 \| ODC1 \| DISEASES 5552 \| SRGN \| DISEASES 81578 \| COL21A1 \| DISEASES 1401 \| CRP \| DISEASES 2012 \| EMP1 \| DISEASES 6926 \| TBX3 \| DISEASES 29969 \| MDFIC \| DISEASES 10913 \| EDAR \| DISEASES 3569 \| IL6 \| DISEASES 4481 \| MSR1 \| DISEASES 4591 \| TRIM37 \| DISEASES 9739 \| SETD1A \| DISEASES 23523 \| CABIN1 \| DISEASES 3553 \| IL1B \| DISEASES 9424 \| KCNK6 \| DISEASES 1991 \| ELANE \| DISEASES 9410 \| SNRNP40 \| DISEASES 4722 \| NDUFS3 \| DISEASES 943 \| TNFRSF8 \| DISEASES 51191 \| HERC5 \| DISEASES 5443 \| POMC \| DISEASES 2028 \| ENPEP \| DISEASES 3700 \| ITIH4 \| DISEASES 8128 \| ST8SIA2 \| DISEASES 3687 \| ITGAX \| DISEASES 805 \| CALM2 \| DISEASES 196743 \| PAOX \| DISEASES 136991 \| ASZ1 \| DISEASES 10 \| NAT2 \| DISEASES 64768 \| IPPK \| DISEASES 4681 \| NBL1 \| DISEASES 808 \| CALM3 \| DISEASES 729230 \| CCR2 \| DISEASES 1234 \| CCR5 \| DISEASES 84666 \| RETNLB \| DISEASES 213 \| ALB \| DISEASES 10085 \| EDIL3 \| DISEASES 9607 \| CARTPT \| DISEASES 1437 \| CSF2 \| DISEASES 5896 \| RAG1 \| DISEASES 89927 \| C16orf45 \| DISEASES 197257 \| LDHD \| DISEASES 124872 \| B4GALNT2 \| DISEASES 64581 \| CLEC7A \| DISEASES 260434 \| PYDC1 \| DISEASES 10663 \| CXCR6 \| DISEASES 7275 \| TUB \| DISEASES 7386 \| UQCRFS1 \| DISEASES 200316 \| APOBEC3F \| DISEASES 7298 \| TYMS \| DISEASES 1776 \| DNASE1L3 \| DISEASES 29851 \| ICOS \| DISEASES 3752 \| KCND3 \| DISEASES 80381 \| CD276 \| DISEASES 1149 \| CIDEA \| DISEASES 10938 \| EHD1 \| DISEASES 3996 \| LLGL1 \| DISEASES 55 \| ACPP \| DISEASES 2314 \| FLII \| DISEASES 3628 \| INPP1 \| DISEASES 114971 \| PTPMT1 \| DISEASES 1237 \| CCR8 \| DISEASES 2318 \| FLNC \| DISEASES 200504 \| GKN2 \| DISEASES 2689 \| GH2 \| DISEASES 2938 \| GSTA1 \| DISEASES 9094 \| UNC119 \| DISEASES 51477 \| ISYNA1 \| DISEASES 3266 \| ERAS \| DISEASES 1368 \| CPM \| DISEASES 4521 \| NUDT1 \| DISEASES 9516 \| LITAF \| DISEASES 7975 \| MAFK \| DISEASES 5570 \| PKIB \| DISEASES 801 \| CALM1 \| DISEASES 987 \| LRBA \| DISEASES 9034 \| CCRL2 \| DISEASES 1524 \| CX3CR1 \| DISEASES 1201 \| CLN3 \| DISEASES 2993 \| GYPA \| DISEASES 4519 \| MT-CYB \| DISEASES 4535 \| MT-ND1 \| DISEASES 7257 \| TSNAX \| DISEASES 1378 \| CR1 \| DISEASES 6375 \| XCL1 \| DISEASES 6675 \| UAP1 \| DISEASES 4582 \| MUC1 \| DISEASES 117145 \| THEM4 \| DISEASES 257 \| ALX3 \| DISEASES 959 \| CD40LG \| DISEASES 93377 \| OPALIN \| DISEASES 9124 \| PDLIM1 \| DISEASES 26027 \| ACOT11 \| DISEASES 80351 \| TNKS2 \| DISEASES 64170 \| CARD9 \| DISEASES 958 \| CD40 \| DISEASES 6441 \| SFTPD \| DISEASES 9682 \| KDM4A \| DISEASES 3633 \| INPP5B \| DISEASES 6865 \| TACR2 \| DISEASES 253430 \| IPMK \| DISEASES 1043 \| CD52 \| DISEASES 7133 \| TNFRSF1B \| DISEASES 29968 \| PSAT1 \| DISEASES 160897 \| GPR180 \| DISEASES 1993 \| ELAVL2 \| DISEASES 91543 \| RSAD2 \| DISEASES 3239 \| HOXD13 \| DISEASES 55773 \| TBC1D23 \| DISEASES 9560 \| CCL4L2 \| DISEASES 2919 \| CXCL1 \| DISEASES 4668 \| NAGA \| DISEASES 84433 \| CARD11 \| DISEASES 10622 \| POLR3G \| DISEASES 8131 \| NPRL3 \| DISEASES 3803 \| KIR2DL2 \| DISEASES 60489 \| APOBEC3G \| DISEASES 23066 \| CAND2 \| DISEASES 1638 \| DCT \| DISEASES 85443 \| DCLK3 \| DISEASES 113235 \| SLC46A1 \| DISEASES 1719 \| DHFR \| DISEASES 7124 \| TNF \| DISEASES 84671 \| ZNF347 \| DISEASES 388372 \| CCL4L1 \| DISEASES 139728 \| PNCK \| DISEASES 3586 \| IL10 \| DISEASES 3712 \| IVD \| DISEASES 2649 \| NR6A1 \| DISEASES 5238 \| PGM3 \| DISEASES 930 \| CD19 \| DISEASES 1232 \| CCR3 \| DISEASES 3684 \| ITGAM \| DISEASES 567 \| B2M \| DISEASES 246734 \| NPCDR1 \| DISEASES
Locus	(Waiting for update.)

Disease ID	446
Disease	pneumocystosis
Integrated Phenotype	(Waiting for update.)
Text Mined Phenotype	HPO \| Name \| Sentences' Count(Total Phenotypes:1) HP:0100280 \| Morbus Crohn \| 1

Disease ID	446
Disease	pneumocystosis
Manually Symptom	UMLS \| Name(Total Manually Symptoms:2) C2711548 \| infectious process C0024291 \| hemophagocytic syndrome
Text Mined Symptom	(Waiting for update.)

Manually Genotype(Total Text Mining Genotypes:0)
(Waiting for update.)

All Snps(Total Genotypes:1)
snpId	pubmedId	geneId	geneSymbol	diseaseId	sourceId	sentence	score	Year	geneSymbol_dbSNP	CHROMOSOME	POS	REF	ALT
rs3204849	22046140	9034	CCRL2	umls:C1535939	BeFree	Role of exonic variation in chemokine receptor genes on AIDS: CCRL2 F167Y association with pneumocystis pneumonia.	0.000271442	2011	CCRL2;LOC102724297	3	46408579	T	A

GWASdb Annotation(Total Genotypes:0)
(Waiting for update.)

GWASdb Snp Trait(Total Genotypes:0)
(Waiting for update.)

Mapped by lexical matching(Total Items:0)
(Waiting for update.)

Mapped by homologous gene(Total Items:0)
(Waiting for update.)

Chemical(Total Drugs:7)
CUI	ChemicalName	ChemicalID	CasRN	DiseaseName	DiseaseID	DirectEvidence	PubMedIDs
C1535939	atovaquone	D053626	94015-53-9	pneumonia, pneumocystis	MESH:D011020	therapeutic	10447880
C1535939	cyclophosphamide	D003520	50-18-0	pneumonia, pneumocystis	MESH:D011020	marker/mechanism	19078457
C1535939	dapsone	D003622	80-08-0	pneumonia, pneumocystis	MESH:D011020	therapeutic	7481974
C1535939	methotrexate	D008727	1959/5/2	pneumonia, pneumocystis	MESH:D011020	marker/mechanism	19078457
C1535939	temozolomide	C047246	85622-93-1	pneumonia, pneumocystis	MESH:D011020	marker/mechanism	16757971
C1535939	trimethoprim	D014295	738-70-5	pneumonia, pneumocystis	MESH:D011020	therapeutic	23896474
C1535939	zidovudine	D015215	30516-87-1	pneumonia, pneumocystis	MESH:D011020	therapeutic	9665308

FDA approved drug and dosage information(Total Drugs:0)
(Waiting for update.)

FDA labeling changes(Total Drugs:0)
(Waiting for update.)

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