PedAM
Pediatric Disease Annotations & Medicines
| pneumococcal meningitis | ||||
| Disease ID | 612 |
|---|---|
| Disease | pneumococcal meningitis |
| Definition | An acute purulent infection of the meninges and subarachnoid space caused by Streptococcus pneumoniae, most prevalent in children and adults over the age of 60. This illness may be associated with OTITIS MEDIA; MASTOIDITIS; SINUSITIS; RESPIRATORY TRACT INFECTIONS; sickle cell disease (ANEMIA, SICKLE CELL); skull fractures; and other disorders. Clinical manifestations include FEVER; HEADACHE; neck stiffness; and somnolence followed by SEIZURES; focal neurologic deficits (notably DEAFNESS); and COMA. (From Miller et al., Merritt's Textbook of Neurology, 9th ed, p111) |
| Synonym | meningitides, streptococcus pneumoniae meningitis pneumococcal meningitis, pneumococcal meningitis, pneumococcal [disease/finding] meningitis, streptococcus pneumoniae pneumococcal meningitides pneumococcal meningitis (disorder) streptococcus pneumoniae meningitides streptococcus pneumoniae meningitis |
| Orphanet | |
| DOID | |
| ICD10 | |
| UMLS | C0025295 |
| MeSH | |
| SNOMED-CT | |
| Comorbidity | UMLS | Disease | Sentences' Count(Total Sentences:18) C0007785 | cerebral infarct | 2 C0007785 | cerebral infarction | 2 C0037886 | sphenoid sinusitis | 2 C0025289 | meningitis | 2 C0022116 | ischaemia | 1 C0151740 | intracranial hypertension | 1 C0085437 | bacterial meningitis | 1 C0270629 | epidural abscess | 1 C1704437 | respiratory distress syndrome | 1 C0270612 | leukoencephalopathy | 1 C1527311 | brain edema | 1 C0008049 | chickenpox | 1 C0456909 | vision loss | 1 C0018784 | sensorineural hearing loss | 1 C0035222 | acute respiratory distress syndrome | 1 C0032269 | pneumococcal infection | 1 C0037199 | sinusitis | 1 C0034372 | quadriplegia | 1 |
| Curated Gene | (Waiting for update.) |
| Inferring Gene | (Waiting for update.) |
| Text Mined Gene | (Waiting for update.) |
| Locus | (Waiting for update.) |
| Disease ID | 612 |
|---|---|
| Disease | pneumococcal meningitis |
| Integrated Phenotype | (Waiting for update.) |
| Text Mined Phenotype | HPO | Name | Sentences' Count(Total Phenotypes:20) HP:0001287 | Meningitis | 2 HP:0100543 | Cognitive deficits | 2 HP:0002721 | Immunodeficiency | 2 HP:0030049 | Brain abscess | 1 HP:0001974 | Leukocytosis | 1 HP:0000365 | Hearing impairment | 1 HP:0002445 | Paralysis of all four limbs | 1 HP:0008619 | Bilateral sensorineural hearing impairment | 1 HP:0011947 | Respiratory infection | 1 HP:0001268 | Mental deterioration | 1 HP:0000572 | Visual loss | 1 HP:0001945 | Fever | 1 HP:0012714 | Severe hearing loss | 1 HP:0000407 | sensorineural hearing loss | 1 HP:0100806 | Sepsis | 1 HP:0002181 | Cerebral edema | 1 HP:0002315 | Headaches | 1 HP:0002352 | Leukoencephalopathy | 1 HP:0002617 | Aneurysmal dilatation | 1 HP:0012735 | Coughing | 1 |
| Disease ID | 612 |
|---|---|
| Disease | pneumococcal meningitis |
| Manually Symptom | UMLS | Name(Total Manually Symptoms:15) C1565662 | acute renal insufficiency C1527311 | brain edema C1393529 | vascular complications C0344431 | monomorphic ventricular tachycardia C0340098 | neurogenic pulmonary edema C0265149 | acute purulent pericarditis C0236073 | cerebellar infarction C0151740 | intracranial hypertension C0085650 | purpura fulminans C0038454 | cerebral infarction C0032268 | pneumocephalus C0019270 | herniation C0019061 | hemolytic-uremic syndrome C0004610 | bacteraemia C0002871 | anaemia |
| Text Mined Symptom | UMLS | Name | Sentences' Count(Total Symptoms:4) C0032268 | pneumocephalus | 3 C0007785 | cerebral infarction | 2 C0004610 | bacteraemia | 1 C1527311 | brain edema | 1 |
Manually Genotype(Total Text Mining Genotypes:0) |
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| (Waiting for update.) |
All Snps(Total Genotypes:0) | |
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| (Waiting for update.) | |
GWASdb Annotation(Total Genotypes:0) | |
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| (Waiting for update.) | |
GWASdb Snp Trait(Total Genotypes:0) | |
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| (Waiting for update.) | |
Mapped by lexical matching(Total Items:0) |
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| (Waiting for update.) |
Mapped by homologous gene(Total Items:0) |
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| (Waiting for update.) |
Chemical(Total Drugs:4) | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| CUI | ChemicalName | ChemicalID | CasRN | DiseaseName | DiseaseID | DirectEvidence | PubMedIDs | ||
| C0025295 | cefotaxime | D002439 | 63527-52-6 | meningitis, pneumococcal | MESH:D008586 | therapeutic | 1495831 | ||
| C0025295 | chloramphenicol | D002701 | 56-75-7 | meningitis, pneumococcal | MESH:D008586 | therapeutic | 1923686 | ||
| C0025295 | rifampin | D012293 | 13292-46-1 | meningitis, pneumococcal | MESH:D008586 | therapeutic | 7870156 | ||
| C0025295 | vancomycin | D014640 | 1404-90-6 | meningitis, pneumococcal | MESH:D008586 | therapeutic | 7870156 | ||
FDA approved drug and dosage information(Total Drugs:0) | |
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| (Waiting for update.) | |
FDA labeling changes(Total Drugs:0) | |
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| (Waiting for update.) | |