PedAM

Pediatric Disease Annotations & Medicines


	pleural effusion disorder

Disease ID	1822
Disease	pleural effusion disorder
Definition	Presence of fluid in the pleural cavity resulting from excessive transudation or exudation from the pleural surfaces. It is a sign of disease and not a diagnosis in itself.
Synonym	effusion pleural effusion, pleural effusions, pleural pleural cavity effusion pleural effusion pleural effusion (disorder) pleural effusion [disease/finding] pleural effusion nos pleural effusion nos (disorder) pleural effusion, nos pleural effusions unspecified pleural effusion
UMLS	C0032227
MeSH	D010996
SNOMED-CT	SNOMEDCT_US_2016_09_01:60046008
Comorbidity	UMLS \| Disease \| Sentences' Count(Total Sentences:253) C0242379 \| lung cancer \| 66 C0032285 \| pneumonia \| 54 C0018801 \| heart failure \| 18 C0007131 \| nsclc \| 13 C0001418 \| adenocarcinoma \| 13 C0041296 \| tuberculosis \| 13 C0152013 \| lung adenocarcinoma \| 13 C0006142 \| breast cancer \| 11 C0032326 \| pneumothorax \| 11 C0023418 \| leukemia \| 10 C0149925 \| small cell lung cancer \| 10 C0007131 \| non-small cell lung cancer \| 9 C1145670 \| respiratory failure \| 8 C0024299 \| lymphoma \| 7 C0031039 \| pericardial effusion \| 7 C0032231 \| pleuritis \| 6 C0030305 \| pancreatitis \| 6 C0034065 \| pulmonary embolism \| 5 C0684249 \| lung carcinoma \| 5 C0032231 \| pleurisy \| 5 C0023890 \| cirrhosis \| 5 C0036202 \| sarcoidosis \| 5 C0018801 \| cardiac failure \| 5 C1261473 \| sarcoma \| 4 C0023890 \| liver cirrhosis \| 4 C0026764 \| multiple myeloma \| 4 C0023470 \| myeloid leukemia \| 4 C0345967 \| malignant mesothelioma \| 4 C0409974 \| lupus erythematosus \| 4 C0221348 \| yellow nail syndrome \| 4 C0002726 \| amyloidosis \| 4 C0024141 \| systemic lupus erythematosus \| 4 C0019829 \| hodgkin lymphoma \| 4 C1140680 \| ovarian ca \| 4 C0041327 \| pulmonary tb \| 4 C0020538 \| hypertension \| 4 C0041327 \| pulmonary tuberculosis \| 3 C0024305 \| non-hodgkin lymphoma \| 3 C1140680 \| ovarian cancer \| 3 C0023473 \| chronic myeloid leukemia \| 3 C0026934 \| pleuropneumonia \| 3 C0019158 \| hepatitis \| 3 C0023895 \| liver disease \| 3 C0153676 \| lung metastasis \| 3 C0018802 \| congestive heart failure \| 3 C0155862 \| pneumococcal pneumonia \| 3 C0032285 \| pneumonitis \| 3 C0023467 \| acute myeloid leukemia \| 3 C0025064 \| mediastinitis \| 2 C0001339 \| acute pancreatitis \| 2 C0812413 \| malignant pleural mesothelioma \| 2 C0153676 \| lung metastases \| 2 C0268407 \| cardiac amyloidosis \| 2 C0032302 \| mycoplasma pneumonia \| 2 C0006285 \| bronchopneumonia \| 2 C0023418 \| leukaemia \| 2 C0023467 \| acute myeloid leukaemia \| 2 C0035229 \| respiratory insufficiency \| 2 C0023281 \| leishmaniasis \| 2 C0018802 \| congestive cardiac failure \| 2 C0030424 \| paragonimiasis \| 2 C0023470 \| myelogenous leukemia \| 2 C0024117 \| chronic obstructive pulmonary disease \| 2 C0149521 \| chronic pancreatitis \| 2 C0032290 \| aspiration pneumonia \| 2 C0001418 \| adenocarcinomas \| 2 C0036220 \| kaposi sarcoma \| 2 C0031046 \| pericarditis \| 2 C0376545 \| hematological malignancies \| 2 C0041326 \| tuberculous pleuritis \| 2 C0019284 \| diaphragmatic hernia \| 2 C0007102 \| colon cancer \| 2 C0004626 \| bacterial pneumonia \| 2 C0020305 \| fetal hydrops \| 2 C0009782 \| connective tissue disease \| 2 C0034063 \| pulmonary edema \| 2 C0026934 \| mycoplasma \| 2 C0007177 \| cardiac tamponade \| 2 C0020541 \| portal hypertension \| 2 C0022661 \| chronic kidney disease \| 2 C0015230 \| rash \| 2 C0006271 \| bronchiolitis \| 2 C0014175 \| endometriosis \| 2 C0023473 \| chronic myelogenous leukemia \| 2 C0026764 \| myeloma \| 2 C0034063 \| pulmonary oedema \| 2 C0006267 \| bronchiectasis \| 2 C0278619 \| extramedullary plasmacytoma \| 2 C0037280 \| infestation \| 1 C0001261 \| actinomycosis \| 1 C0032302 \| mycoplasma pneumoniae pneumonia \| 1 C0021053 \| immunologic disease \| 1 C0152013 \| adenocarcinoma of the lung \| 1 C0007121 \| bronchogenic carcinoma \| 1 C0024117 \| chronic obstructive pulmonary disease (copd) \| 1 C0032226 \| pleural disease \| 1 C0003615 \| appendicitis \| 1 C0032285 \| pneumoniae \| 1 C0023290 \| visceral leishmaniasis \| 1 C0023283 \| cutaneous leishmaniasis \| 1 C1279296 \| chronic leukaemia \| 1 C0016085 \| filariasis \| 1 C0149925 \| small cell carcinoma \| 1 C0278883 \| metastatic melanoma \| 1 C0023470 \| myeloid leukaemia \| 1 C0041326 \| pleural tuberculosis \| 1 C0879615 \| stromal tumor \| 1 C0151740 \| intracranial hypertension \| 1 C0158683 \| polycystic liver disease \| 1 C0262428 \| collagen vascular disease \| 1 C0021053 \| immune disease \| 1 C0476089 \| endometrial carcinoma \| 1 C0039445 \| hereditary haemorrhagic telangiectasia \| 1 C0085568 \| buruli ulcer \| 1 C0018799 \| cardiac disease \| 1 C0476089 \| endometrial ca \| 1 C0023418 \| leukaemias \| 1 C0549473 \| thyroid carcinoma \| 1 C0017636 \| glioblastoma \| 1 C0027947 \| neutropenia \| 1 C0004031 \| allergic bronchopulmonary aspergillosis \| 1 C0149925 \| small cell lung carcinoma \| 1 C0154143 \| toxic multinodular goiter \| 1 C0152021 \| congenital heart disease \| 1 C1619734 \| pulmonary arterial hypertension \| 1 C0008049 \| varicella \| 1 C0085083 \| ovarian hyperstimulation syndrome \| 1 C0023903 \| liver cancer \| 1 C0024115 \| pulmonary disease \| 1 C0025202 \| malignant melanoma \| 1 C0004030 \| aspergillosis \| 1 C0037753 \| sparganosis \| 1 C0032300 \| lobar pneumonia \| 1 C0022661 \| end-stage renal disease \| 1 C0041471 \| typhus \| 1 C0036439 \| scoliosis \| 1 C0023473 \| chronic myelogenous leukemia (cml) \| 1 C0149985 \| secondary syphilis \| 1 C0151332 \| active tuberculosis \| 1 C0032285 \| pneumonias \| 1 C0085669 \| acute leukemia \| 1 C0342208 \| multinodular goiter \| 1 C0032131 \| plasmacytoma \| 1 C0080032 \| malignant pleural effusion \| 1 C0019829 \| hodgkin's lymphoma \| 1 C0001175 \| acquired immune deficiency \| 1 C0238198 \| gastrointestinal stromal tumor \| 1 C0035435 \| rheumatic disease \| 1 C0037116 \| silicosis \| 1 C0153676 \| pulmonary metastases \| 1 C0041321 \| miliary tb \| 1 C0002871 \| anaemia \| 1 C0006145 \| breast disease \| 1 C0022658 \| kidney disease \| 1 C0013502 \| hydatid cyst \| 1 C0042769 \| viral infection \| 1 C0854906 \| benign schwannoma \| 1 C0031154 \| peritonitis \| 1 C0013502 \| hydatid cysts \| 1 C1279296 \| chronic leukemia \| 1 C0206633 \| angiomyolipomas \| 1 C0007112 \| prostate adenocarcinoma \| 1 C0024110 \| lung abscess \| 1 C0009186 \| coccidioidomycosis \| 1 C0031039 \| pericardial effusions \| 1 C1368910 \| mature teratoma \| 1 C0376545 \| hematologic malignancies \| 1 C0025202 \| melanoma \| 1 C0031048 \| constrictive pericarditis \| 1 C0042769 \| viral infections \| 1 C0019829 \| hodgkins lymphoma \| 1 C0029423 \| osteochondroma \| 1 C0040053 \| thrombosis \| 1 C0152276 \| myeloid sarcoma \| 1 C0014118 \| endocarditis \| 1 C0039128 \| syphilis \| 1 C0035204 \| respiratory disease \| 1 C0032305 \| pneumocystis pneumonia \| 1 C0001175 \| acquired immune deficiency syndrome (aids) \| 1 C0022658 \| renal disease \| 1 C0376358 \| prostate cancer \| 1 C0079748 \| lymphoblastic lymphoma \| 1 C0029925 \| ovarian carcinoma \| 1 C0013990 \| emphysema \| 1 C0684249 \| carcinoma of the lung \| 1 C0162429 \| malnourished \| 1 C0023903 \| liver tumor \| 1 C0023484 \| plasma cell leukemia \| 1 C0023434 \| chronic lymphocytic leukemia \| 1 C0278678 \| metastatic renal cell carcinoma \| 1 C0238033 \| male breast cancer \| 1 C0036421 \| systemic sclerosis \| 1 C0016045 \| fibroma \| 1 C0600260 \| obstructive pulmonary disease \| 1 C0034063 \| lung edema \| 1 C0001430 \| adenoma \| 1 C0020676 \| hypothyroidism \| 1 C0024131 \| lupus vulgaris \| 1 C0027809 \| schwannoma \| 1 C0085404 \| poems syndrome \| 1 C0028242 \| nocardiosis \| 1 C0042075 \| urinary tract disorders \| 1 C0007131 \| non-small cell lung carcinoma \| 1 C0699885 \| carcinoma of the urinary bladder \| 1 C0042075 \| uropathy \| 1 C0085278 \| antiphospholipid syndrome \| 1 C0003486 \| aortic aneurysm \| 1 C0010414 \| cryptococcosis \| 1 C0684249 \| pulmonary carcinoma \| 1 C0024419 \| waldenstrom's macroglobulinemia \| 1 C0019100 \| dengue hemorrhagic fever \| 1 C0011644 \| scleroderma \| 1 C0040034 \| thrombocytopenia \| 1 C0024115 \| pulmonary diseases \| 1 C0007115 \| thyroid ca \| 1 C0039101 \| synovial sarcoma \| 1 C0018799 \| heart disease \| 1 C0024305 \| non-hodgkin's lymphoma \| 1 C0017160 \| gastroenteritis \| 1 C0034072 \| cardiopulmonary disease \| 1 C0020255 \| hydrocephalus \| 1 C0024305 \| non-hodgkins lymphoma \| 1 C0003165 \| coal workers' pneumoconiosis \| 1 C0553580 \| ewing sarcoma \| 1 C0032273 \| pneumoconiosis \| 1 C0041326 \| tuberculous pleurisy \| 1 C0178879 \| obstructive uropathy \| 1 C0085669 \| acute leukaemia \| 1 C0149782 \| squamous cell lung carcinoma \| 1 C0024236 \| lymphedema \| 1 C0862312 \| epithelioid mesothelioma \| 1 C0205944 \| epithelioid sarcoma \| 1 C0024299 \| lymphomas \| 1 C0023448 \| lymphocytic leukemia \| 1 C0018023 \| nodular goiter \| 1 C0035439 \| rheumatic heart disease \| 1 C0035435 \| rheumatic diseases \| 1 C0011633 \| dermatomyositis \| 1 C0010633 \| cystadenoma \| 1 C0017536 \| giardiasis \| 1 C0036472 \| scrub typhus \| 1 C0001175 \| acquired immune deficiency syndrome \| 1 C0021053 \| immunologic diseases \| 1 C0007134 \| renal cell carcinoma \| 1 C0020542 \| pulmonary hypertension \| 1 C1377913 \| pleural mesothelioma \| 1 C0024115 \| lung disease \| 1 C0019204 \| hepatocellular carcinoma \| 1 C0035222 \| acute respiratory distress syndrome \| 1 C0149521 \| recurrent pancreatitis \| 1 C0042373 \| vascular disease \| 1 C0024214 \| lymphangiectasis \| 1 C0006272 \| bronchiolitis obliterans \| 1
Curated Gene	Entrez_id \| Symbol \| Resource(Total Genes:1) TNF \| 7124 \| CTD_human
Inferring Gene	(Waiting for update.)
Text Mined Gene	(Waiting for update.)
Locus	(Waiting for update.)

Disease ID	1822
Disease	pleural effusion disorder
Integrated Phenotype	(Waiting for update.)
Text Mined Phenotype	HPO \| Name \| Sentences' Count(Total Phenotypes:143) HP:0002090 \| Pneumonia \| 50 HP:0100750 \| Pulmonary atelectasis \| 31 HP:0002094 \| Dyspnea \| 25 HP:0001635 \| Congestive heart failure \| 23 HP:0002664 \| Neoplasia \| 19 HP:0001541 \| Ascites \| 17 HP:0002107 \| Collapsed lung \| 13 HP:0030078 \| Lung adenocarcinoma \| 12 HP:0000969 \| Dropsy \| 12 HP:0030731 \| Carcinoma \| 11 HP:0003002 \| Breast carcinoma \| 11 HP:0030357 \| Small cell lung carcinoma \| 11 HP:0002102 \| Pleuritis \| 11 HP:0001909 \| Leukemia \| 10 HP:0030358 \| Non-small cell lung carcinoma \| 10 HP:0012531 \| Pain \| 10 HP:0002665 \| Lymphoma \| 7 HP:0002878 \| Respiratory failure \| 7 HP:0001698 \| Pericardial effusions \| 7 HP:0001640 \| Increased heart size \| 7 HP:0002098 \| Respiratory distress \| 6 HP:0100749 \| Thoracic pain \| 6 HP:0002113 \| Pulmonary infiltrates \| 6 HP:0001733 \| Pancreatic inflammation \| 6 HP:0002089 \| Hypoplastic lungs \| 5 HP:0100598 \| Pulmonary oedema \| 5 HP:0002204 \| Pulmonary embolism \| 5 HP:0012189 \| Hodgkin disease \| 5 HP:0005506 \| Chronic myeloid leukemia \| 5 HP:0002716 \| Lymph node hyperplasia \| 5 HP:0002835 \| Aspiration \| 5 HP:0001394 \| Hepatic cirrhosis \| 5 HP:0010310 \| Chylothorax \| 5 HP:0001945 \| Fever \| 4 HP:0100242 \| Sarcoma \| 4 HP:0100001 \| Malignant mesothelioma \| 4 HP:0012324 \| Myeloid leukemia \| 4 HP:0006775 \| Multiple myeloma \| 4 HP:0100615 \| Neoplasm of the ovary \| 4 HP:0002725 \| Systemic lupus erythematosus \| 4 HP:0011034 \| Amyloid disease \| 4 HP:0012539 \| Non-Hodgkin lymphoma \| 3 HP:0100632 \| Pulmonary sequestration \| 3 HP:0004808 \| Acute myelogenous leukemia \| 3 HP:0012115 \| Liver inflammation \| 3 HP:0002093 \| progressive respiratory failure \| 3 HP:0000822 \| Hypertension \| 3 HP:0011950 \| Bronchiolitis \| 2 HP:0002617 \| Aneurysmal dilatation \| 2 HP:0000776 \| Diaphragmatic hernia \| 2 HP:0010618 \| Ovarian fibroma \| 2 HP:0012622 \| Chronic kidney disease \| 2 HP:0002896 \| Liver cancer \| 2 HP:0012721 \| Venous malformations \| 2 HP:0006510 \| Chronic obstructive pulmonary disease \| 2 HP:0003003 \| Colon cancer \| 2 HP:0030127 \| Endometriosis \| 2 HP:0002110 \| Bronchiectasis \| 2 HP:0030005 \| Capillary leak \| 2 HP:0030843 \| Cardiac amyloidosis \| 2 HP:0001701 \| Pericarditis \| 2 HP:0100523 \| Hepatic abscess \| 2 HP:0011951 \| Aspiration pneumonia \| 2 HP:0001735 \| Acute pancreatitis \| 2 HP:0006521 \| Pulmonary lymphangiectasis \| 2 HP:0001409 \| Portal hypertension \| 2 HP:0006280 \| Chronic pancreas inflammation \| 2 HP:0030879 \| Interlobular septal thickening \| 1 HP:0006532 \| Pneumonia, recurrent episodes \| 1 HP:0012254 \| Ewing's sarcoma \| 1 HP:0004757 \| Paroxysmal atrial fibrillation \| 1 HP:0005550 \| Chronic lymphatic leukemia \| 1 HP:0100730 \| Bronchogenic cyst \| 1 HP:0200058 \| Angiosarcoma \| 1 HP:0001875 \| Neutropenia \| 1 HP:0001651 \| Thoracic situs inversus \| 1 HP:0100843 \| Glioblastoma \| 1 HP:0002875 \| Exertional dyspnea \| 1 HP:0002647 \| Aortic dissection \| 1 HP:0002586 \| Peritonitis \| 1 HP:0100520 \| Oliguria \| 1 HP:0100526 \| Neoplasm of the lung \| 1 HP:0012114 \| Endometrial carcinoma \| 1 HP:0011106 \| Depleted blood volume \| 1 HP:0100008 \| Schwann cell tumour \| 1 HP:0005558 \| Chronic leukemia \| 1 HP:0100844 \| Pancreatic fistula \| 1 HP:0004942 \| Aortic aneurysm \| 1 HP:0100324 \| Progressive systemic scleroderma \| 1 HP:0100027 \| Recurring pancreatitis \| 1 HP:0002960 \| Autoimmune condition \| 1 HP:0002563 \| Constrictive pericarditis \| 1 HP:0001649 \| Tachycardia \| 1 HP:0002880 \| Respiratory difficulties \| 1 HP:0100723 \| Gastrointestinal stroma tumor \| 1 HP:0030359 \| Squamous cell lung carcinoma \| 1 HP:0001903 \| Anemia \| 1 HP:0002890 \| Thyroid carcinoma \| 1 HP:0001297 \| Cerebral vascular events \| 1 HP:0012735 \| Coughing \| 1 HP:0011857 \| Plasmacytoma \| 1 HP:0005994 \| Nodular goiter \| 1 HP:0005206 \| Pancreatic pseudocyst \| 1 HP:0003075 \| Hypoproteinemia \| 1 HP:0000988 \| Exanthem \| 1 HP:0001944 \| Dehydration \| 1 HP:0006557 \| Polycystic liver disease \| 1 HP:0100827 \| Lymphocytosis \| 1 HP:0010960 \| Bronchopulmonary sequestration \| 1 HP:0002097 \| Pulmonary emphysema \| 1 HP:0004936 \| Blood clot in vein \| 1 HP:0011921 \| Exudative pleural effusion \| 1 HP:0100790 \| Hernia \| 1 HP:0002092 \| Pulmonary artery hypertension \| 1 HP:0005162 \| Left ventricular impairment \| 1 HP:0012570 \| Synovial sarcoma \| 1 HP:0002861 \| Melanoma \| 1 HP:0005987 \| Multinodular goiter \| 1 HP:0200119 \| Acute liver inflammation \| 1 HP:0001790 \| Nonimmune hydrops fetalis \| 1 HP:0100002 \| Pleural mesothelioma \| 1 HP:0030431 \| Osteochondromas \| 1 HP:0002789 \| Increased respiratory rate or depth of breathing \| 1 HP:0045073 \| Serositis \| 1 HP:0003281 \| Increased ferritin \| 1 HP:0002315 \| Headaches \| 1 HP:0005110 \| Atrial fibrillation \| 1 HP:0002488 \| Acute leukemias \| 1 HP:0030830 \| Crackles \| 1 HP:0010614 \| Fibroma \| 1 HP:0006706 \| Cystic liver disease \| 1 HP:0001004 \| Lymphatic obstruction \| 1 HP:0003774 \| End-stage renal failure \| 1 HP:0003073 \| Hypoalbuminaemia \| 1 HP:0002108 \| Spontaneous pneumothorax \| 1 HP:0005584 \| Renal cell carcinoma \| 1 HP:0011946 \| Constrictive bronchiolitis \| 1 HP:0001873 \| Low platelet count \| 1 HP:0000821 \| Underactive thyroid \| 1 HP:0002650 \| Scoliosis \| 1 HP:0012125 \| Prostate cancer \| 1 HP:0001433 \| Enlarged liver and spleen \| 1 HP:0002721 \| Immunodeficiency \| 1

Disease ID	1822
Disease	pleural effusion disorder
Manually Symptom	(Waiting for update.)
Text Mined Symptom	UMLS \| Name \| Sentences' Count(Total Symptoms:15) C0242379 \| lung cancer \| 63 C0013404 \| dyspnea \| 25 C0041296 \| tuberculosis \| 12 C0001418 \| adenocarcinoma \| 12 C0009450 \| infection \| 11 C1145670 \| respiratory failure \| 7 C0231303 \| distress \| 6 C0014175 \| endometriosis \| 2 C0041326 \| tuberculous pleuritis \| 2 C0024305 \| non-hodgkin's lymphoma \| 1 C0030299 \| pancreatic pseudocyst \| 1 C0041326 \| tuberculous pleurisy \| 1 C0013404 \| dyspnoea \| 1 C0024115 \| pulmonary diseases \| 1 C0345967 \| malignant mesothelioma \| 1

Manually Genotype(Total Text Mining Genotypes:0)
(Waiting for update.)

All Snps(Total Genotypes:0)
(Waiting for update.)

GWASdb Annotation(Total Genotypes:0)
(Waiting for update.)

GWASdb Snp Trait(Total Genotypes:0)
(Waiting for update.)

Mapped by lexical matching(Total Items:0)
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Mapped by homologous gene(Total Items:0)
(Waiting for update.)

Chemical(Total Drugs:11)
CUI	ChemicalName	ChemicalID	CasRN	DiseaseName	DiseaseID	DirectEvidence	PubMedIDs
C0032227	ampicillin	D000667	69-53-4	pleural effusion	MESH:D010996	marker/mechanism	889204
C0032227	arsenic trioxide	C006632	1327-53-3	pleural effusion	MESH:D010996	marker/mechanism	12669407
C0032227	carmustine	D002330	154-93-8	pleural effusion	MESH:D010996	marker/mechanism	18344943
C0032227	clozapine	D003024	5786-21-0	pleural effusion	MESH:D010996	marker/mechanism	14969785
C0032227	cyclophosphamide	D003520	50-18-0	pleural effusion	MESH:D010996	marker/mechanism	25023062
C0032227	indomethacin	D007213	53-86-1	pleural effusion	MESH:D010996	marker/mechanism	3579483
C0032227	methotrexate	D008727	1959/5/2	pleural effusion	MESH:D010996	marker/mechanism	8064737
C0032227	minoxidil	D008914	38304-91-5	pleural effusion	MESH:D010996	marker/mechanism	7111124
C0032227	thalidomide	D013792	50-35-1	pleural effusion	MESH:D010996	marker/mechanism	12756431
C0032227	tretinoin	D014212	302-79-4	pleural effusion	MESH:D010996	marker/mechanism	10607690
C0032227	valproic acid	D014635	99-66-1	pleural effusion	MESH:D010996	marker/mechanism	14515923

FDA approved drug and dosage information(Total Drugs:0)
(Waiting for update.)

FDA labeling changes(Total Drugs:0)
(Waiting for update.)

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