PedAM

Pediatric Disease Annotations & Medicines


	pleomorphic adenoma

Disease ID	1753
Disease	pleomorphic adenoma
Definition	A benign, slow-growing tumor, most commonly of the salivary gland, occurring as a small, painless, firm nodule, usually of the parotid gland, but also found in any major or accessory salivary gland anywhere in the oral cavity. It is most often seen in women in the fifth decade. Histologically, the tumor presents a variety of cells: cuboidal, columnar, and squamous cells, showing all forms of epithelial growth. (Dorland, 27th ed)
Synonym	adenoma pleomorphic adenoma, pleomorphic adenoma, pleomorphic [disease/finding] adenomas, pleomorphic chondroid syringoma chondroid syringomas mixed salivary gland tumor mixed salivary gland tumour mixed tumor mixed tumor of salivary gland mixed tumor of the salivary gland mixed tumor, nos mixed tumor, salivary gland type mixed tumor, salivary gland type, nos mixed tumors mixed tumour mixed tumour, salivary gland type pleomorphic adenoma (morphologic abnormality) pleomorphic adenomas salivary gland tumor, mixed syringoma, chondroid syringomas, chondroid tumor mix tumor, mixed, benign tumour mix
DOID	DOID:452 DOID:154
UMLS	C0026277
MeSH	D008949
Comorbidity	UMLS \| Disease \| Sentences' Count(Total Sentences:15) C0007137 \| squamous cell carcinoma \| 2 C0017525 \| giant cell tumor \| 1 C0041296 \| tuberculosis \| 1 C0520679 \| obstructive sleep apnoea \| 1 C0684249 \| carcinoma of the lung \| 1 C0037315 \| sleep apnoea \| 1 C0242379 \| lung cancer \| 1 C0149782 \| squamous cell carcinoma of the lung \| 1 C0153676 \| lung metastases \| 1 C0153676 \| pulmonary metastases \| 1 C0023418 \| leukemia \| 1 C0152545 \| primary tuberculosis \| 1 C0023448 \| lymphocytic leukemia \| 1 C0015469 \| facial nerve paralysis \| 1 C0023434 \| chronic lymphocytic leukemia \| 1
Curated Gene	(Waiting for update.)
Inferring Gene	(Waiting for update.)
Text Mined Gene	Entrez_id \| Symbol \| Score \| Resource(Total Genes:190) 64132 \| XYLT2 \| DISEASES 51564 \| HDAC7 \| DISEASES 43847 \| KLK14 \| DISEASES 3861 \| KRT14 \| DISEASES 9817 \| KEAP1 \| DISEASES 50 \| ACO2 \| DISEASES 4313 \| MMP2 \| DISEASES 6449 \| SGTA \| DISEASES 1048 \| CEACAM5 \| DISEASES 3082 \| HGF \| DISEASES 7431 \| VIM \| DISEASES 218 \| ALDH3A1 \| DISEASES 595 \| CCND1 \| DISEASES 4254 \| KITLG \| DISEASES 4617 \| MYF5 \| DISEASES 2026 \| ENO2 \| DISEASES 4172 \| MCM3 \| DISEASES 7475 \| WNT6 \| DISEASES 3217 \| HOXB7 \| DISEASES 51248 \| PDZD11 \| DISEASES 4656 \| MYOG \| DISEASES 6718 \| AKR1D1 \| DISEASES 5326 \| PLAGL2 \| DISEASES 3860 \| KRT13 \| DISEASES 4654 \| MYOD1 \| DISEASES 3852 \| KRT5 \| DISEASES 9113 \| LATS1 \| DISEASES 92747 \| BPIFB1 \| DISEASES 140683 \| BPIFA2 \| DISEASES 2670 \| GFAP \| DISEASES 55226 \| NAT10 \| DISEASES 1019 \| CDK4 \| DISEASES 570 \| BAAT \| DISEASES 51050 \| PI15 \| DISEASES 6386 \| SDCBP \| DISEASES 4069 \| LYZ \| DISEASES 999 \| CDH1 \| DISEASES 7077 \| TIMP2 \| DISEASES 54487 \| DGCR8 \| DISEASES 6855 \| SYP \| DISEASES 8190 \| MIA \| DISEASES 3977 \| LIFR \| DISEASES 822 \| CAPG \| DISEASES 390 \| RND3 \| DISEASES 23095 \| KIF1B \| DISEASES 5290 \| PIK3CA \| DISEASES 5593 \| PRKG2 \| DISEASES 2247 \| FGF2 \| DISEASES 6774 \| STAT3 \| DISEASES 3818 \| KLKB1 \| DISEASES 7297 \| TYK2 \| DISEASES 4171 \| MCM2 \| DISEASES 1462 \| VCAN \| DISEASES 4240 \| MFGE8 \| DISEASES 64784 \| CRTC3 \| DISEASES 1009 \| CDH11 \| DISEASES 7157 \| TP53 \| DISEASES 2064 \| ERBB2 \| DISEASES 148327 \| CREB3L4 \| DISEASES 55435 \| AP1AR \| DISEASES 1404 \| HAPLN1 \| DISEASES 81555 \| YIPF5 \| DISEASES 3176 \| HNMT \| DISEASES 8562 \| DENR \| DISEASES 11197 \| WIF1 \| DISEASES 132 \| ADK \| DISEASES 392255 \| GDF6 \| DISEASES 3815 \| KIT \| DISEASES 5304 \| PIP \| DISEASES 6285 \| S100B \| DISEASES 6271 \| S100A1 \| DISEASES 3856 \| KRT8 \| DISEASES 7471 \| WNT1 \| DISEASES 64399 \| HHIP \| DISEASES 10818 \| FRS2 \| DISEASES 1398 \| CRK \| DISEASES 4589 \| MUC7 \| DISEASES 649 \| BMP1 \| DISEASES 79145 \| CHCHD7 \| DISEASES 4176 \| MCM7 \| DISEASES 3219 \| HOXB9 \| DISEASES 3265 \| HRAS \| DISEASES 947 \| CD34 \| DISEASES 5655 \| KLK10 \| DISEASES 5062 \| PAK2 \| DISEASES 6440 \| SFTPC \| DISEASES 1728 \| NQO1 \| DISEASES 25898 \| RCHY1 \| DISEASES 3039 \| HBA1 \| DISEASES 81618 \| ITM2C \| DISEASES 7329 \| UBE2I \| DISEASES 55553 \| SOX6 \| DISEASES 5241 \| PGR \| DISEASES 5324 \| PLAG1 \| DISEASES 221937 \| FOXK1 \| DISEASES 246329 \| STAC3 \| DISEASES 3855 \| KRT7 \| DISEASES 5155 \| PDGFB \| DISEASES 277 \| AMY1B \| DISEASES 5271 \| SERPINB8 \| DISEASES 25834 \| MGAT4C \| DISEASES 1937 \| EEF1G \| DISEASES 3838 \| KPNA2 \| DISEASES 8013 \| NR4A3 \| DISEASES 2246 \| FGF1 \| DISEASES 23583 \| SMUG1 \| DISEASES 8788 \| DLK1 \| DISEASES 5275 \| SERPINB13 \| DISEASES 27255 \| CNTN6 \| DISEASES 2272 \| FHIT \| DISEASES 10488 \| CREB3 \| DISEASES 1499 \| CTNNB1 \| DISEASES 23373 \| CRTC1 \| DISEASES 26232 \| FBXO2 \| DISEASES 51297 \| BPIFA1 \| DISEASES 6275 \| S100A4 \| DISEASES 5154 \| PDGFA \| DISEASES 5325 \| PLAGL1 \| DISEASES 7080 \| NKX2-1 \| DISEASES 55107 \| ANO1 \| DISEASES 331 \| XIAP \| DISEASES 2980 \| GUCA2A \| DISEASES 753 \| LDLRAD4 \| DISEASES 4151 \| MB \| DISEASES 4311 \| MME \| DISEASES 6663 \| SOX10 \| DISEASES 4916 \| NTRK3 \| DISEASES 2736 \| GLI2 \| DISEASES 280 \| AMY2B \| DISEASES 800 \| CALD1 \| DISEASES 5743 \| PTGS2 \| DISEASES 4688 \| NCF2 \| DISEASES 4582 \| MUC1 \| DISEASES 6273 \| S100A2 \| DISEASES 6277 \| S100A6 \| DISEASES 284486 \| THEM5 \| DISEASES 278 \| AMY1C \| DISEASES 276 \| AMY1A \| DISEASES 2258 \| FGF13 \| DISEASES 7809 \| BSND \| DISEASES 1288 \| COL4A6 \| DISEASES 4318 \| MMP9 \| DISEASES 2022 \| ENG \| DISEASES 8200 \| GDF5 \| DISEASES 367 \| AR \| DISEASES 3339 \| HSPG2 \| DISEASES 10211 \| FLOT1 \| DISEASES 29968 \| PSAT1 \| DISEASES 4609 \| MYC \| DISEASES 3853 \| KRT6A \| DISEASES 116840 \| CNTROB \| DISEASES 4781 \| NFIB \| DISEASES 80333 \| KCNIP4 \| DISEASES 6624 \| FSCN1 \| DISEASES 5268 \| SERPINB5 \| DISEASES 7341 \| SUMO1 \| DISEASES 12 \| SERPINA3 \| DISEASES 307 \| ANXA4 \| DISEASES 55193 \| PBRM1 \| DISEASES 2319 \| FLOT2 \| DISEASES 4239 \| MFAP4 \| DISEASES 2120 \| ETV6 \| DISEASES 4338 \| MOCS2 \| DISEASES 8091 \| HMGA2 \| DISEASES 23119 \| HIC2 \| DISEASES 176 \| ACAN \| DISEASES 10551 \| AGR2 \| DISEASES 3481 \| IGF2 \| DISEASES 2260 \| FGFR1 \| DISEASES 1029 \| CDKN2A \| DISEASES 8848 \| TSC22D1 \| DISEASES 6660 \| SOX5 \| DISEASES 960 \| CD44 \| DISEASES 2130 \| EWSR1 \| DISEASES 64747 \| MFSD1 \| DISEASES 4588 \| MUC6 \| DISEASES 2263 \| FGFR2 \| DISEASES 84441 \| MAML2 \| DISEASES 10046 \| MAMLD1 \| DISEASES 4583 \| MUC2 \| DISEASES 6513 \| SLC2A1 \| DISEASES 4193 \| MDM2 \| DISEASES 4585 \| MUC4 \| DISEASES 23089 \| PEG10 \| DISEASES 5890 \| RAD51B \| DISEASES 6917 \| TCEA1 \| DISEASES 7033 \| TFF3 \| DISEASES 4586 \| MUC5AC \| DISEASES 4190 \| MDH1 \| DISEASES 55384 \| MEG3 \| DISEASES
Locus	(Waiting for update.)

Disease ID	1753
Disease	pleomorphic adenoma
Integrated Phenotype	(Waiting for update.)
Text Mined Phenotype	HPO \| Name \| Sentences' Count(Total Phenotypes:13) HP:0002664 \| Neoplasia \| 11 HP:0030731 \| Carcinoma \| 6 HP:0002835 \| Aspiration \| 3 HP:0002860 \| Squamous cell carcinoma \| 2 HP:0002176 \| Spinal cord compression \| 1 HP:0005550 \| Chronic lymphatic leukemia \| 1 HP:0001611 \| Hypernasal speech \| 1 HP:0000405 \| Conductive hearing loss \| 1 HP:0003470 \| Inability to move \| 1 HP:0010535 \| Sleep apnea \| 1 HP:0010628 \| Facial palsy, unilateral or bilateral \| 1 HP:0100271 \| Hyponasal speech \| 1 HP:0001909 \| Leukemia \| 1

Disease ID	1753
Disease	pleomorphic adenoma
Manually Symptom	(Waiting for update.)
Text Mined Symptom	UMLS \| Name \| Sentences' Count(Total Symptoms:1) C1608408 \| malignant transformation \| 8

Manually Genotype(Total Text Mining Genotypes:0)
(Waiting for update.)

All Snps(Total Genotypes:2)
snpId	pubmedId	geneId	geneSymbol	diseaseId	sourceId	sentence	score	Year	geneSymbol_dbSNP	CHROMOSOME	POS	REF	ALT
rs121913273	23851329	5290	PIK3CA	umls:C0026277	BeFree	The only case of SDC with anaplastic transformation showed PIK3CA p.H1047R mutation, whereas 1 of 2 PIK3CA p.E542K mutations was identified in SDC arising in a pleomorphic adenoma.	0.000271442	2013	PIK3CA	3	179218294	G	A
rs121913279	23851329	5290	PIK3CA	umls:C0026277	BeFree	The only case of SDC with anaplastic transformation showed PIK3CA p.H1047R mutation, whereas 1 of 2 PIK3CA p.E542K mutations was identified in SDC arising in a pleomorphic adenoma.	0.000271442	2013	PIK3CA	3	179234297	A	G,T

GWASdb Annotation(Total Genotypes:0)
(Waiting for update.)

GWASdb Snp Trait(Total Genotypes:0)
(Waiting for update.)

Mapped by lexical matching(Total Items:0)
(Waiting for update.)

Mapped by homologous gene(Total Items:0)
(Waiting for update.)

Chemical(Total Drugs:0)
(Waiting for update.)

FDA approved drug and dosage information(Total Drugs:0)
(Waiting for update.)

FDA labeling changes(Total Drugs:0)
(Waiting for update.)

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