PedAM
Pediatric Disease Annotations & Medicines
| plasmodium falciparum malaria | ||||
| Disease ID | 820 |
|---|---|
| Disease | plasmodium falciparum malaria |
| Integrated Phenotype | (Waiting for update.) |
| Text Mined Phenotype | HPO | Name | Sentences' Count(Total Phenotypes:11) HP:0100758 | Gangrene | 2 HP:0001945 | Fever | 2 HP:0000112 | Nephropathy | 1 HP:0005961 | Low blood arginine levels | 1 HP:0000099 | Glomerular nephritis | 1 HP:0001259 | Coma | 1 HP:0001919 | Acute renal failure | 1 HP:0001903 | Anemia | 1 HP:0000952 | Yellow skin | 1 HP:0001685 | Myocardial fibrosis | 1 HP:0001047 | Atopic dermatitis | 1 |
| Disease ID | 820 |
|---|---|
| Disease | plasmodium falciparum malaria |
| Manually Symptom | (Waiting for update.) |
| Text Mined Symptom | UMLS | Name | Sentences' Count(Total Symptoms:6) C0009450 | infection | 8 C0242723 | parasitemia | 2 C0015967 | fever | 2 C0002871 | anemia | 1 C0017658 | glomerulonephritis | 1 C0752303 | urological manifestation | 1 |
Manually Genotype(Total Text Mining Genotypes:0) |
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| (Waiting for update.) |
All Snps(Total Genotypes:7) | |||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| snpId | pubmedId | geneId | geneSymbol | diseaseId | sourceId | sentence | score | Year | geneSymbol_dbSNP | CHROMOSOME | POS | REF | ALT |
| rs12212067 | 25421486 | 2309 | FOXO3 | umls:C0024535 | BeFree | The FOXO3A variant rs12212067T>G is associated with increased inflammatory responses to Plasmodium falciparum malaria, indicating a role of the FOXO3-dependent pathway in malaria. | 0.000271442 | 2014 | FOXO3 | 6 | 108659993 | T | G |
| rs1799724 | 17493155 | 7124 | TNF | umls:C0024535 | BeFree | We examined a possible association of three single nucleotide polymorphisms (SNPs) of the tumor necrosis factor alpha (TNF) promoter -1031T>C (rs1799964), -863C>A (rs1800630), and -857C>T (rs1799724) with severe malaria in 466 adult patients having Plasmodium falciparum malaria in northwest Thailand. | 0.027394561 | 2007 | LTA;TNF | 6 | 31574705 | C | T |
| rs1799964 | 17493155 | 7124 | TNF | umls:C0024535 | BeFree | We examined a possible association of three single nucleotide polymorphisms (SNPs) of the tumor necrosis factor alpha (TNF) promoter -1031T>C (rs1799964), -863C>A (rs1800630), and -857C>T (rs1799724) with severe malaria in 466 adult patients having Plasmodium falciparum malaria in northwest Thailand. | 0.027394561 | 2007 | LTA;TNF;LOC100287329 | 6 | 31574531 | T | C |
| rs1800630 | 17493155 | 7124 | TNF | umls:C0024535 | BeFree | We examined a possible association of three single nucleotide polymorphisms (SNPs) of the tumor necrosis factor alpha (TNF) promoter -1031T>C (rs1799964), -863C>A (rs1800630), and -857C>T (rs1799724) with severe malaria in 466 adult patients having Plasmodium falciparum malaria in northwest Thailand. | 0.027394561 | 2007 | LTA;TNF | 6 | 31574699 | C | A |
| rs2234711 | 19712753 | 3459 | IFNGR1 | umls:C0024535 | BeFree | To examine possible association of the IFN-gamma receptor 1 (IFNGR1) polymorphisms with cerebral malaria, 312 adult patients with Plasmodium falciparum malaria (203 mild and 109 cerebral malaria patients) living in northwest Thailand were genotyped for six single nucleotide polymorphisms (SNPs) including -56T/C (rs2234711) and a microsatellite marker in IFNGR1. | 0.000271442 | 2009 | IFNGR1 | 6 | 137219383 | A | G |
| rs3091307 | 23521898 | 3596 | IL13 | umls:C0024535 | BeFree | As such, the association between the IL-13 variants -7402 T/G (rs7719175) and -4729G/A (rs3091307) and susceptibility to SMA was determined in children (n = 387) presenting with clinical symptoms of falciparum malaria and resident in a holoendemic transmission region in western Kenya. | 0.005005506 | 2013 | LOC101927761 | 5 | 132653444 | A | G |
| rs7719175 | 23521898 | 3596 | IL13 | umls:C0024535 | BeFree | As such, the association between the IL-13 variants -7402 T/G (rs7719175) and -4729G/A (rs3091307) and susceptibility to SMA was determined in children (n = 387) presenting with clinical symptoms of falciparum malaria and resident in a holoendemic transmission region in western Kenya. | 0.005005506 | 2013 | LOC101927761 | 5 | 132650771 | T | G |
GWASdb Annotation(Total Genotypes:0) | |
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| (Waiting for update.) | |
GWASdb Snp Trait(Total Genotypes:0) | |
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| (Waiting for update.) | |
Mapped by lexical matching(Total Items:0) |
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| (Waiting for update.) |
Mapped by homologous gene(Total Items:0) |
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| (Waiting for update.) |
Chemical(Total Drugs:12) | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| CUI | ChemicalName | ChemicalID | CasRN | DiseaseName | DiseaseID | DirectEvidence | PubMedIDs | ||
| C0024535 | amodiaquine | D000655 | 86-42-0 | malaria, falciparum | MESH:D016778 | therapeutic | 11791962 | ||
| C0024535 | atovaquone | D053626 | 94015-53-9 | malaria, falciparum | MESH:D016778 | therapeutic | 11130385 | ||
| C0024535 | chloroquine | D002738 | 1954/5/7 | malaria, falciparum | MESH:D016778 | therapeutic | 12735648 | ||
| C0024535 | clotrimazole | D003022 | 23593-75-1 | malaria, falciparum | MESH:D016778 | therapeutic | 14993803 | ||
| C0024535 | dapsone | D003622 | 80-08-0 | malaria, falciparum | MESH:D016778 | therapeutic | 10837185 | ||
| C0024535 | folic acid | D005492 | 59-30-3 | malaria, falciparum | MESH:D016778 | therapeutic | 4922770 | ||
| C0024535 | leucovorin | D002955 | 1958/5/9 | malaria, falciparum | MESH:D016778 | therapeutic | 4922770 | ||
| C0024535 | halofantrine | C023768 | 36167-63-2 | malaria, falciparum | MESH:D016778 | therapeutic | 15215119 | ||
| C0024535 | mefloquine | D015767 | 53230-10-7 | malaria, falciparum | MESH:D016778 | therapeutic | 11130224 | ||
| C0024535 | pyrimethamine | D011739 | 58-14-0 | malaria, falciparum | MESH:D016778 | therapeutic | 10837185 | ||
| C0024535 | quinine | D011803 | 130-95-0 | malaria, falciparum | MESH:D016778 | therapeutic | 1101464 | ||
| C0024535 | sulfisoxazole | D013444 | 127-69-5 | malaria, falciparum | MESH:D016778 | therapeutic | 4922770 | ||
FDA approved drug and dosage information(Total Drugs:0) | |
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| (Waiting for update.) | |
FDA labeling changes(Total Drugs:0) | |
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| (Waiting for update.) | |