PedAM
Pediatric Disease Annotations & Medicines
| pituitary tumors | ||||
| Disease ID | 840 |
|---|---|
| Disease | pituitary tumors |
| Definition | Neoplasms which arise from or metastasize to the PITUITARY GLAND. The majority of pituitary neoplasms are adenomas, which are divided into non-secreting and secreting forms. Hormone producing forms are further classified by the type of hormone they secrete. Pituitary adenomas may also be characterized by their staining properties (see ADENOMA, BASOPHIL; ADENOMA, ACIDOPHIL; and ADENOMA, CHROMOPHOBE). Pituitary tumors may compress adjacent structures, including the HYPOTHALAMUS, several CRANIAL NERVES, and the OPTIC CHIASM. Chiasmal compression may result in bitemporal HEMIANOPSIA. |
| Synonym | neoplasm of pituitary neoplasm of pituitary gland neoplasm of pituitary gland (disorder) neoplasm of the pituitary neoplasm of the pituitary gland neoplasm, pituitary neoplasms, pituitary pituitary gland neoplasm pituitary gland tumor pituitary gland tumour pituitary gland--tumors pituitary neopl pituitary neoplasm pituitary neoplasms pituitary neoplasms [disease/finding] pituitary tumor pituitary tumour pituitary tumours tumor of pituitary tumor of pituitary gland tumor of the pituitary tumor of the pituitary gland tumor, pituitary tumors, pituitary tumour of pituitary gland |
| Orphanet | |
| DOID | |
| UMLS | C0032019 |
| MeSH | |
| SNOMED-CT | |
| Comorbidity | UMLS | Disease | Sentences' Count(Total Sentences:21) C0033375 | prolactinomas | 4 C0032000 | pituitary adenomas | 3 C0032000 | pituitary adenoma | 3 C0001206 | acromegaly | 3 C0346300 | pituitary carcinoma | 2 C0020550 | hyperthyroidism | 1 C0346302 | gh-secreting pituitary adenoma | 1 C0406810 | carney syndrome | 1 C0032001 | pituitary apoplexy | 1 C0031511 | phaeochromocytoma | 1 C0025267 | multiple endocrine neoplasia type 1 | 1 C0020514 | hyperprolactinemia | 1 C0001622 | hypercortisolism | 1 C0020619 | hypogonadism | 1 C1333387 | endocrine syndrome | 1 C0027662 | multiple endocrine neoplasia | 1 C0029456 | osteoporosis | 1 C0019621 | langerhans cell histiocytosis | 1 C0271623 | secondary hypogonadism | 1 C0010481 | cushing syndrome | 1 C0002453 | amenorrhea | 1 |
| Curated Gene | Entrez_id | Symbol | Resource(Total Genes:6) |
| Inferring Gene | Entrez_id | Symbol | Resource(Total Genes:1) |
| Text Mined Gene | (Waiting for update.) |
| Locus | (Waiting for update.) |
| Disease ID | 840 |
|---|---|
| Disease | pituitary tumors |
| Integrated Phenotype | (Waiting for update.) |
| Text Mined Phenotype | HPO | Name | Sentences' Count(Total Phenotypes:17) HP:0002664 | Neoplasia | 4 HP:0002315 | Headaches | 3 HP:0002893 | Pituitary adenoma | 3 HP:0000845 | Acromegalic growth | 3 HP:0011763 | Pituitary carcinoma | 2 HP:0000870 | Hyperprolactinemia | 1 HP:0001578 | Hypercortisolism | 1 HP:0000135 | Hypogonadism | 1 HP:0100568 | Endocrine neoplasia | 1 HP:0002045 | Abnormally low body temperature | 1 HP:0002617 | Aneurysmal dilatation | 1 HP:0002894 | Neoplasia of the pancreas | 1 HP:0000939 | Osteoporosis | 1 HP:0000505 | Poor vision | 1 HP:0000141 | Abnormal absence of menstruation | 1 HP:0030731 | Carcinoma | 1 HP:0000836 | Overactive thyroid | 1 |
| Disease ID | 840 |
|---|---|
| Disease | pituitary tumors |
| Manually Symptom | (Waiting for update.) |
| Text Mined Symptom | UMLS | Name | Sentences' Count(Total Symptoms:4) C0018681 | headache | 3 C0422943 | visual symptoms | 1 C0020514 | hyperprolactinemia | 1 C0038454 | apoplexy | 1 |
Manually Genotype(Total Text Mining Genotypes:0) |
|---|
| (Waiting for update.) |
All Snps(Total Genotypes:3) | |||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| snpId | pubmedId | geneId | geneSymbol | diseaseId | sourceId | sentence | score | Year | geneSymbol_dbSNP | CHROMOSOME | POS | REF | ALT |
| rs267606541 | 22527616 | 9049 | AIP | umls:C0032019 | BeFree | Genetic analysis in a patient presenting with meningioma and familial isolated pituitary adenoma (FIPA) reveals selective involvement of the R81X mutation of the AIP gene in the pathogenesis of the pituitary tumor. | 0.018250076 | 2012 | AIP | 11 | 67487147 | C | T |
| rs62635652 | 17234588 | 23418 | CRB1 | umls:C0032019 | BeFree | A single amino acid substitution (Cys249Trp) in Crb1 causes retinal degeneration and deregulates expression of pituitary tumor transforming gene Pttg1. | 0.000271442 | 2007 | CRB1 | 1 | 197344378 | T | A,G |
| rs62635652 | 17234588 | 9232 | PTTG1 | umls:C0032019 | BeFree | A single amino acid substitution (Cys249Trp) in Crb1 causes retinal degeneration and deregulates expression of pituitary tumor transforming gene Pttg1. | 0.106922403 | 2007 | CRB1 | 1 | 197344378 | T | A,G |
GWASdb Annotation(Total Genotypes:0) | |
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| (Waiting for update.) | |
GWASdb Snp Trait(Total Genotypes:0) | |
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| (Waiting for update.) | |
Mapped by lexical matching(Total Items:0) |
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| (Waiting for update.) |
Mapped by homologous gene(Total Items:0) |
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| (Waiting for update.) |
Chemical(Total Drugs:7) | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| CUI | ChemicalName | ChemicalID | CasRN | DiseaseName | DiseaseID | DirectEvidence | PubMedIDs | ||
| C0032019 | cabergoline | C047047 | 81409-90-7 | pituitary neoplasms | MESH:D010911 | therapeutic | 2570719 | ||
| C0032019 | caffeine | D002110 | 1958/8/2 | pituitary neoplasms | MESH:D010911 | marker/mechanism | 6623345 | ||
| C0032019 | diethylstilbestrol | D004054 | 56-53-1 | pituitary neoplasms | MESH:D010911 | marker/mechanism | 11685661 | ||
| C0032019 | octreotide | D015282 | 83150-76-9 | pituitary neoplasms | MESH:D010911 | therapeutic | 11383484 | ||
| C0032019 | temozolomide | C047246 | 85622-93-1 | pituitary neoplasms | MESH:D010911 | therapeutic | 20045804 | ||
| C0032019 | toremifene | D017312 | 89778-26-7 | pituitary neoplasms | MESH:D010911 | therapeutic | 8402624 | ||
| C0032019 | valproic acid | D014635 | 99-66-1 | pituitary neoplasms | MESH:D010911 | marker/mechanism | 1729766 | ||
FDA approved drug and dosage information(Total Drugs:0) | |
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| (Waiting for update.) | |
FDA labeling changes(Total Drugs:0) | |
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| (Waiting for update.) | |