PedAM

Pediatric Disease Annotations & Medicines


	pituitary apoplexy

Disease ID	322
Disease	pituitary apoplexy
Definition	The sudden loss of blood supply to the PITUITARY GLAND, leading to tissue NECROSIS and loss of function (PANHYPOPITUITARISM). The most common cause is hemorrhage or INFARCTION of a PITUITARY ADENOMA. It can also result from acute hemorrhage into SELLA TURCICA due to HEAD TRAUMA; INTRACRANIAL HYPERTENSION; or other acute effects of central nervous system hemorrhage. Clinical signs include severe HEADACHE; HYPOTENSION; bilateral visual disturbances; UNCONSCIOUSNESS; and COMA.
Synonym	apoplexy, pituitary pituitary apoplexy (disorder) pituitary apoplexy [disease/finding] pituitary gland apoplexy
Orphanet	ORPHANET:95613
DOID	DOID:1129
UMLS	C0032001
MeSH	D010899
SNOMED-CT	SNOMEDCT_US_2016_09_01:237701005
Comorbidity	UMLS \| Disease \| Sentences' Count(Total Sentences:38) C0032000 \| pituitary adenoma \| 5 C0001430 \| adenoma \| 4 C0011847 \| diabetes \| 4 C0011848 \| diabetes insipidus \| 4 C0854486 \| functioning pituitary adenoma \| 2 C0007785 \| cerebral infarct \| 2 C0019100 \| dengue hemorrhagic fever \| 2 C0338078 \| non-functioning pituitary adenoma \| 2 C0007785 \| cerebral infarction \| 2 C0028866 \| third nerve palsy \| 2 C0151311 \| cranial nerve palsy \| 1 C0376358 \| prostate cancer \| 1 C0011880 \| diabetic ketoacidosis \| 1 C0029089 \| ophthalmoplegia \| 1 C0028866 \| oculomotor nerve palsy \| 1 C0155320 \| cortical blindness \| 1 C0032002 \| pituitary disease \| 1 C0019937 \| horner's syndrome \| 1 C0242342 \| sheehan's syndrome \| 1 C0007785 \| cerebral ischemia \| 1 C0009402 \| colorectal cancer \| 1 C0007113 \| rectal cancer \| 1 C0456909 \| blindness \| 1 C0007121 \| bronchogenic carcinoma \| 1 C0242343 \| panhypopituitarism \| 1 C0442874 \| neuropathy \| 1 C0020635 \| pituitary deficiency \| 1 C0040034 \| thrombocytopenia \| 1 C1565489 \| renal insufficiency \| 1 C0001623 \| adrenal insufficiency \| 1 C0001206 \| acromegaly \| 1 C0740392 \| middle cerebral artery infarction \| 1 C0206734 \| hemangioblastoma \| 1 C0221406 \| cushing's disease \| 1 C0029134 \| optic neuritis \| 1 C0022116 \| ischemia \| 1 C0020635 \| hypopituitarism \| 1 C0271355 \| abducens nerve palsy \| 1
Curated Gene	Entrez_id \| Symbol \| Resource(Total Genes:1) CRH \| 1392 \| CTD_human
Inferring Gene	(Waiting for update.)
Text Mined Gene	Entrez_id \| Symbol \| Score \| Resource(Total Genes:22) 328 \| APEX1 \| DISEASES 3630 \| INS \| DISEASES 9739 \| SETD1A \| DISEASES 5443 \| POMC \| DISEASES 2796 \| GNRH1 \| DISEASES 1392 \| CRH \| DISEASES 9049 \| AIP \| DISEASES 6750 \| SST \| DISEASES 340348 \| TSPAN33 \| DISEASES 5617 \| PRL \| DISEASES 3479 \| IGF1 \| DISEASES 7200 \| TRH \| DISEASES 4221 \| MEN1 \| DISEASES 26136 \| TES \| DISEASES 3713 \| IVL \| DISEASES 60495 \| HPSE2 \| DISEASES 4878 \| NPPA \| DISEASES 551 \| AVP \| DISEASES 29072 \| SETD2 \| DISEASES 3712 \| IVD \| DISEASES 4782 \| NFIC \| DISEASES 102723508 \| KANTR \| DISEASES
Locus	(Waiting for update.)

Disease ID	322
Disease	pituitary apoplexy
Integrated Phenotype	HPO \| Name(Total Integrated Phenotypes:41) HP:0001578 \| Hypercortisolism HP:0000845 \| Growth hormone excess HP:0000980 \| Pallor HP:0011748 \| Adrenocorticotropic hormone deficiency HP:0002921 \| Abnormality of the cerebrospinal fluid HP:0001289 \| Confusion HP:0040075 \| Hypopituitarism HP:0030591 \| Abnormal kinetic perimetry test HP:0001945 \| Fever HP:0007663 \| Reduced visual acuity HP:0002315 \| Headache HP:0002902 \| Hyponatremia HP:0000822 \| Hypertension HP:0001943 \| Hypoglycemia HP:0000508 \| Ptosis HP:0000863 \| Central diabetes insipidus HP:0001259 \| Coma HP:0100829 \| Galactorrhea HP:0002615 \| Hypotension HP:0000815 \| Hypergonadotropic hypogonadism HP:0030907 \| Thunderclap headache HP:0012378 \| Fatigue HP:0030521 \| Bitemporal hemianopia HP:0002893 \| Pituitary adenoma HP:0000802 \| Impotence HP:0002017 \| Nausea and vomiting HP:0000651 \| Diplopia HP:0000876 \| Oligomenorrhea HP:0030595 \| Abnormal static automated perimetry test HP:0008202 \| Prolactin deficiency HP:0000824 \| Growth hormone deficiency HP:0006824 \| Cranial nerve paralysis HP:0008245 \| Pituitary hypothyroidism HP:0000622 \| Blurred vision HP:0001895 \| Normochromic anemia HP:0100661 \| Trigeminal neuralgia HP:0001262 \| Excessive daytime somnolence HP:0011499 \| Mydriasis HP:0000613 \| Photophobia HP:0002339 \| Abnormality of the caudate nucleus HP:0000870 \| Prolactin excess
Text Mined Phenotype	HPO \| Name \| Sentences' Count(Total Phenotypes:33) HP:0002893 \| Pituitary adenoma \| 5 HP:0002315 \| Headaches \| 3 HP:0000873 \| Diabetes insipidus \| 3 HP:0002902 \| Hyponatremia \| 2 HP:0001297 \| Cerebral vascular events \| 2 HP:0002664 \| Neoplasia \| 2 HP:0001873 \| Low platelet count \| 2 HP:0000602 \| Ophthalmoplegia \| 1 HP:0000083 \| Renal insufficiency \| 1 HP:0002277 \| Horner's syndrome \| 1 HP:0001259 \| Coma \| 1 HP:0012125 \| Prostate cancer \| 1 HP:0000846 \| Hypoadrenalism \| 1 HP:0000871 \| Panhypopituitarism \| 1 HP:0001953 \| Diabetic ketosis \| 1 HP:0002013 \| Emesis \| 1 HP:0040075 \| Hypopituitarism \| 1 HP:0000845 \| Acromegalic growth \| 1 HP:0006824 \| Cranial nerve palsy \| 1 HP:0000505 \| Poor vision \| 1 HP:0012342 \| Macroprolactinoma \| 1 HP:0100704 \| Cortical visual impairment \| 1 HP:0001342 \| Intracerebral hemorrhage \| 1 HP:0002039 \| Anorexia \| 1 HP:0100653 \| Optic neuritis \| 1 HP:0010797 \| Hemangioblastoma \| 1 HP:0002617 \| Aneurysmal dilatation \| 1 HP:0012246 \| Oculomotor nerve palsy \| 1 HP:0001993 \| Ketoacidosis \| 1 HP:0002637 \| Brain ischemia \| 1 HP:0002138 \| Subarachnoid hemorrhage \| 1 HP:0000618 \| Blindness \| 1 HP:0001945 \| Fever \| 1

Disease ID	322
Disease	pituitary apoplexy
Manually Symptom	UMLS \| Name(Total Manually Symptoms:16) C1839611 \| n syndrome C0917798 \| cerebral ischaemia C0752244 \| rathke's cleft cyst C0751815 \| internal carotid artery dissection C0687720 \| central diabetes insipidus C0456909 \| blindness C0240059 \| intraventricular hemorrhage C0221406 \| cushing's disease C0085616 \| vasospasm C0038454 \| stroke C0029134 \| optic neuritis C0028866 \| oculomotor nerve palsy C0022972 \| eaton-lambert syndrome C0017547 \| gigantism C0007785 \| cerebral infarct C0002418 \| amblyopia
Text Mined Symptom	UMLS \| Name \| Sentences' Count(Total Symptoms:6) C0038454 \| stroke \| 2 C0007785 \| cerebral infarct \| 2 C0456909 \| blindness \| 1 C0221406 \| cushing's disease \| 1 C0029134 \| optic neuritis \| 1 C0028866 \| oculomotor nerve palsy \| 1

Manually Genotype(Total Text Mining Genotypes:0)
(Waiting for update.)

All Snps(Total Genotypes:0)
(Waiting for update.)

GWASdb Annotation(Total Genotypes:0)
(Waiting for update.)

GWASdb Snp Trait(Total Genotypes:0)
(Waiting for update.)

Mapped by lexical matching(Total Items:0)
(Waiting for update.)

Mapped by homologous gene(Total Items:0)
(Waiting for update.)

Chemical(Total Drugs:2)
CUI	ChemicalName	ChemicalID	CasRN	DiseaseName	DiseaseID	DirectEvidence	PubMedIDs
C0032001	chlorpromazine	D002746	50-53-3	pituitary apoplexy	MESH:D010899	marker/mechanism	718334
C0032001	leuprolide	D016729	53714-56-0	pituitary apoplexy	MESH:D010899	marker/mechanism	12507807

FDA approved drug and dosage information(Total Drugs:0)
(Waiting for update.)

FDA labeling changes(Total Drugs:0)
(Waiting for update.)

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