PedAM

Pediatric Disease Annotations & Medicines


	phobic disorder

Disease ID	1107
Disease	phobic disorder
Definition	Anxiety disorders in which the essential feature is persistent and irrational fear of a specific object, activity, or situation that the individual feels compelled to avoid. The individual recognizes the fear as excessive or unreasonable.
Synonym	[x]phobic anxiety disorder, unspecified [x]phobic anxiety disorder, unspecified (disorder) [x]phobic anxiety disorders [x]phobic anxiety disorders (disorder) abnormal fear disorder, phobic disorders, phobic neuroses, phobic phobia phobia (finding) phobia nos phobia unspecified phobia unspecified (finding) phobia, nos phobia, unspecified phobias phobic anxiety phobic anxiety disorder phobic anxiety disorder (disorder) phobic dis phobic disorder (disorder) phobic disorder nos phobic disorder nos (finding) phobic disorders phobic disorders [disease/finding] phobic neuroses phobic neurosis
DOID	DOID:591
UMLS	C0349231
MeSH	D010698
SNOMED-CT	SNOMEDCT_US_2016_09_01:386810004;SNOMEDCT_US_2016_09_01:386808001
Curated Gene	Entrez_id \| Symbol \| Resource(Total Genes:2) CAT \| 847 \| CTD_human PRL \| 5617 \| CTD_human
Inferring Gene	Entrez_id \| Symbol \| Resource(Total Genes:1) 1312 \| COMT \| infer
Text Mined Gene	Entrez_id \| Symbol \| Score \| Resource(Total Genes:114) 1815 \| DRD4 \| DISEASES 5607 \| MAP2K5 \| DISEASES 4710 \| NDUFB4 \| DISEASES 27248 \| ERLEC1 \| DISEASES 5020 \| OXT \| DISEASES 6530 \| SLC6A2 \| DISEASES 41 \| ASIC1 \| DISEASES 55907 \| CMAS \| DISEASES 5754 \| PTK7 \| DISEASES 9450 \| LY86 \| DISEASES 5997 \| RGS2 \| DISEASES 2703 \| GJA8 \| DISEASES 1088 \| CEACAM8 \| DISEASES 7166 \| TPH1 \| DISEASES 51540 \| SCLY \| DISEASES 80896 \| NPL \| DISEASES 80326 \| WNT10A \| DISEASES 2572 \| GAD2 \| DISEASES 5004 \| ORM1 \| DISEASES 6095 \| RORA \| DISEASES 6532 \| SLC6A4 \| DISEASES 2033 \| EP300 \| DISEASES 7301 \| TYRO3 \| DISEASES 2743 \| GLRB \| DISEASES 51665 \| ASB1 \| DISEASES 5443 \| POMC \| DISEASES 64083 \| GOLPH3 \| DISEASES 4986 \| OPRK1 \| DISEASES 10863 \| ADAM28 \| DISEASES 55749 \| CCAR1 \| DISEASES 6531 \| SLC6A3 \| DISEASES 3358 \| HTR2C \| DISEASES 1392 \| CRH \| DISEASES 51594 \| NBAS \| DISEASES 25836 \| NIPBL \| DISEASES 55079 \| FEZF2 \| DISEASES 7123 \| CLEC3B \| DISEASES 51151 \| SLC45A2 \| DISEASES 6632 \| SNRPD1 \| DISEASES 54442 \| KCTD5 \| DISEASES 4054 \| LTBP3 \| DISEASES 116844 \| LRG1 \| DISEASES 51181 \| DCXR \| DISEASES 6869 \| TACR1 \| DISEASES 5308 \| PITX2 \| DISEASES 1501 \| CTNND2 \| DISEASES 10645 \| CAMKK2 \| DISEASES 10713 \| USP39 \| DISEASES 151516 \| ASPRV1 \| DISEASES 3350 \| HTR1A \| DISEASES 4026 \| LPP \| DISEASES 91662 \| NLRP12 \| DISEASES 84938 \| ATG4C \| DISEASES 5021 \| OXTR \| DISEASES 57010 \| CABP4 \| DISEASES 121278 \| TPH2 \| DISEASES 277 \| AMY1B \| DISEASES 23762 \| OSBP2 \| DISEASES 887 \| CCKBR \| DISEASES 885 \| CCK \| DISEASES 5025 \| P2RX4 \| DISEASES 135 \| ADORA2A \| DISEASES 3988 \| LIPA \| DISEASES 3363 \| HTR7 \| DISEASES 4889 \| NPY5R \| DISEASES 5493 \| PPL \| DISEASES 349565 \| NMNAT3 \| DISEASES 4128 \| MAOA \| DISEASES 2804 \| GOLGB1 \| DISEASES 1508 \| CTSB \| DISEASES 6633 \| SNRPD2 \| DISEASES 3359 \| HTR3A \| DISEASES 2571 \| GAD1 \| DISEASES 8936 \| WASF1 \| DISEASES 387129 \| NPSR1 \| DISEASES 5792 \| PTPRF \| DISEASES 11169 \| WDHD1 \| DISEASES 1312 \| COMT \| DISEASES 4886 \| NPY1R \| DISEASES 6000 \| RGS7 \| DISEASES 9641 \| IKBKE \| DISEASES 10090 \| UST \| DISEASES 3351 \| HTR1B \| DISEASES 278 \| AMY1C \| DISEASES 276 \| AMY1A \| DISEASES 115004 \| MB21D1 \| DISEASES 2332 \| FMR1 \| DISEASES 81030 \| ZBP1 \| DISEASES 11128 \| POLR3A \| DISEASES 2739 \| GLO1 \| DISEASES 1889 \| ECE1 \| DISEASES 3055 \| HCK \| DISEASES 83715 \| ESPN \| DISEASES 4129 \| MAOB \| DISEASES 3356 \| HTR2A \| DISEASES 2625 \| GATA3 \| DISEASES 6197 \| RPS6KA3 \| DISEASES 2925 \| GRPR \| DISEASES 8544 \| PIR \| DISEASES 833 \| CARS \| DISEASES 56953 \| NT5M \| DISEASES 10345 \| TRDN \| DISEASES 93986 \| FOXP2 \| DISEASES 348180 \| CTU2 \| DISEASES 10163 \| WASF2 \| DISEASES 284252 \| KCTD1 \| DISEASES 121256 \| TMEM132D \| DISEASES 34 \| ACADM \| DISEASES 3925 \| STMN1 \| DISEASES 389549 \| FEZF1 \| DISEASES 627 \| BDNF \| DISEASES 503542 \| SPRN \| DISEASES 5027 \| P2RX7 \| DISEASES 11201 \| POLI \| DISEASES
Locus	(Waiting for update.)

Disease ID	1107
Disease	phobic disorder
Integrated Phenotype	(Waiting for update.)
Text Mined Phenotype	HPO \| Name \| Sentences' Count(Total Phenotypes:2) HP:0001249 \| Mental retardation \| 1 HP:0012531 \| Pain \| 1

Disease ID	1107
Disease	phobic disorder
Manually Symptom	(Waiting for update.)
Text Mined Symptom	(Waiting for update.)

Manually Genotype(Total Text Mining Genotypes:0)
(Waiting for update.)

All Snps(Total Genotypes:5)
snpId	pubmedId	geneId	geneSymbol	diseaseId	sourceId	sentence	score	Year	geneSymbol_dbSNP	CHROMOSOME	POS	REF	ALT
rs1256049	21570196	2100	ESR2	umls:C0349231	BeFree	The A allele of ESR2 rs1256049 was associated with an increased risk of GAD [OR: 2.06, 95% CI: 1.09-3.87], while both ESR1 polymorphisms were specifically associated with phobia.	0.000271442	2011	ESR2	14	64257333	C	T
rs4680	15450911	4128	MAOA	umls:C0349231	BeFree	Functional polymorphisms in the MAO-A uVNTR promoter gene, the COMT gene (Val158Met) exon 4, and the 5-HTT promoter gene (44 bp ins/del) were investigated in 101 patients with phobic disorders of the anxiety spectrum and 202 controls matched to the patients for sex, age and ethnicity.	0.000271442	2004	COMT;MIR4761	22	19963748	G	A
rs4680	15450911	6532	SLC6A4	umls:C0349231	BeFree	Functional polymorphisms in the MAO-A uVNTR promoter gene, the COMT gene (Val158Met) exon 4, and the 5-HTT promoter gene (44 bp ins/del) were investigated in 101 patients with phobic disorders of the anxiety spectrum and 202 controls matched to the patients for sex, age and ethnicity.	0.000271442	2004	COMT;MIR4761	22	19963748	G	A
rs4680	15450911	1312	COMT	umls:C0349231	BeFree	Functional polymorphisms in the MAO-A uVNTR promoter gene, the COMT gene (Val158Met) exon 4, and the 5-HTT promoter gene (44 bp ins/del) were investigated in 101 patients with phobic disorders of the anxiety spectrum and 202 controls matched to the patients for sex, age and ethnicity.	0.002638474	2004	COMT;MIR4761	22	19963748	G	A
rs5751876	20334879	135	ADORA2A	umls:C0349231	BeFree	A variant within the corresponding ADORA2A gene (rs5751876) increased the risk for panic disorder (PD), for elevated anxiety during challenge tests in healthy probands and for anxiety-related arousal in blood-injury phobia.	0.000271442	2010	ADORA2A;ADORA2A-AS1;SPECC1L-ADORA2A	22	24441333	T	C

GWASdb Annotation(Total Genotypes:0)
(Waiting for update.)

GWASdb Snp Trait(Total Genotypes:0)
(Waiting for update.)

Mapped by lexical matching(Total Items:0)
(Waiting for update.)

Mapped by homologous gene(Total Items:0)
(Waiting for update.)

Chemical(Total Drugs:7)
CUI	ChemicalName	ChemicalID	CasRN	DiseaseName	DiseaseID	DirectEvidence	PubMedIDs
C0349231	alprazolam	D000525	28981-97-7	phobic disorders	MESH:D010698	therapeutic	3348461
C0349231	citalopram	D015283	59729-33-8	phobic disorders	MESH:D010698	therapeutic	18208904
C0349231	clozapine	D003024	5786-21-0	phobic disorders	MESH:D010698	marker/mechanism	10665627
C0349231	fluoxetine	D005473	54910-89-3	phobic disorders	MESH:D010698	therapeutic	10665627
C0349231	haloperidol	D006220	52-86-8	phobic disorders	MESH:D010698	marker/mechanism	6946714
C0349231	lorazepam	D008140	846-49-1	phobic disorders	MESH:D010698	marker/mechanism	1544008
C0349231	modafinil	C048833	68693-11-8	phobic disorders	MESH:D010698	therapeutic	12411237

FDA approved drug and dosage information(Total Drugs:0)
(Waiting for update.)

FDA labeling changes(Total Drugs:0)
(Waiting for update.)

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