PedAM

Pediatric Disease Annotations & Medicines


	peripheral vascular disease

Disease ID	496
Disease	peripheral vascular disease
Definition	Pathological processes involving any one of the BLOOD VESSELS in the vasculature outside the HEART.
Synonym	angiopathies, peripheral angiopathy, peripheral arterial diseases peripheral circulatory disorder peripheral circulatory disorders peripheral dis peripheral vascular disease, peripheral vascular diseases, peripheral vascular disorder peripheral vascular disorder vascular peripheral periph vascular dis nos peripheral angiopathies peripheral angiopathy peripheral angiopathy nos peripheral angiopathy, nos peripheral arterial disease peripheral blood vessel disorder peripheral vasc. disease nos peripheral vascular dis peripheral vascular dis. nos peripheral vascular disease (& [nos]) peripheral vascular disease (& [nos]) (disorder) peripheral vascular disease (disorder) peripheral vascular disease (pvd) peripheral vascular disease nos peripheral vascular disease nos (disorder) peripheral vascular disease unspecified peripheral vascular disease, nos peripheral vascular disease, unspecified peripheral vascular diseases peripheral vascular diseases [disease/finding] peripheral vascular disorder pvd pvd - peripheral vascular disease pvd-peripheral vascular disease pvds vasc. dis. periph. nos vascular dis peripheral vascular disease, peripheral vascular diseases, peripheral vascular disorder peripheral
DOID	DOID:341
ICD10	ICD10CM:I73.9
UMLS	C0085096
MeSH	D016491 D058729
SNOMED-CT	SNOMEDCT_US_2016_09_01:400047006
Comorbidity	UMLS \| Disease \| Sentences' Count(Total Sentences:38) C0011847 \| diabetes \| 14 C0022116 \| ischemia \| 5 C0011849 \| diabetes mellitus \| 5 C0021775 \| intermittent claudication \| 5 C0022658 \| kidney disease \| 4 C0022661 \| chronic kidney disease \| 3 C0018799 \| heart disease \| 2 C0040053 \| thrombosis \| 2 C0022658 \| nephropathy \| 2 C0948265 \| metabolic syndrome \| 2 C1561644 \| chronic kidney disease (ckd) \| 2 C0004153 \| atherosclerosis \| 2 C0010068 \| coronary heart disease \| 2 C0014060 \| encephalitis c \| 1 C0029456 \| osteoporosis \| 1 C0022661 \| end-stage renal disease \| 1 C0011881 \| diabetic nephropathy \| 1 C0033860 \| psoriasis \| 1 C0027051 \| myocardial infarct \| 1 C0031511 \| pheochromocytoma \| 1 C0155626 \| acute myocardial infarction \| 1 C0151744 \| myocardial ischemia \| 1 C0011860 \| type 2 diabetes \| 1 C0003507 \| aortic valve stenosis \| 1 C0022679 \| cystic kidney \| 1 C0011860 \| type ii diabetes mellitus \| 1 C0022658 \| renal disease \| 1 C0028754 \| obesity \| 1 C0034735 \| raynaud's phenomenon \| 1 C0010068 \| coronary artery disease \| 1 C0011860 \| type ii diabetes \| 1 C0011570 \| depression \| 1 C0025309 \| meningoencephalitis \| 1 C0027051 \| myocardial infarction \| 1 C0020538 \| hypertension \| 1 C0033953 \| sexual dysfunction \| 1 C0019360 \| herpes zoster \| 1 C0019360 \| zoster \| 1
Curated Gene	Entrez_id \| Symbol \| Resource(Total Genes:3) SCN9A \| 6335 \| GHR CYP1A1 \| 1543 \| CTD_human DAB2IP \| 153090 \| CTD_human
Inferring Gene	Entrez_id \| Symbol \| Resource(Total Genes:46) 338 \| APOB \| infer 2161 \| F12 \| infer 2162 \| F13A1 \| infer 64805 \| P2RY12 \| infer 1636 \| ACE \| infer 1524 \| CX3CR1 \| infer 1535 \| CYBA \| infer 2147 \| F2 \| infer 2153 \| F5 \| infer 3553 \| IL1B \| infer 4846 \| NOS3 \| infer 949 \| SCARB1 \| infer 118 \| ADD1 \| infer 183 \| AGT \| infer 387715 \| ARMS2 \| infer 6347 \| CCL2 \| infer 1136 \| CHRNA3 \| infer 64478 \| CSMD1 \| infer 1588 \| CYP19A1 \| infer 2099 \| ESR1 \| infer 2100 \| ESR2 \| infer 2243 \| FGA \| infer 2244 \| FGB \| infer 2266 \| FGG \| infer 3077 \| HFE \| infer 3383 \| ICAM1 \| infer 3569 \| IL6 \| infer 3690 \| ITGB3 \| infer 3990 \| LIPC \| infer 4018 \| LPA \| infer 4312 \| MMP1 \| infer 4314 \| MMP3 \| infer 4318 \| MMP9 \| infer 4524 \| MTHFR \| infer 4547 \| MTTP \| infer 4602 \| MYB \| infer 114884 \| OSBPL10 \| infer 255738 \| PCSK9 \| infer 7941 \| PLA2G7 \| infer 5468 \| PPARG \| infer 6401 \| SELE \| infer 6568 \| SLC17A1 \| infer 6715 \| SRD5A1 \| infer 6716 \| SRD5A2 \| infer 164656 \| TMPRSS6 \| infer 55187 \| VPS13D \| infer
Text Mined Gene	Entrez_id \| Symbol \| Score \| Resource(Total Genes:302) 5662 \| PSD \| DISEASES 5954 \| RCN1 \| DISEASES 2249 \| FGF4 \| DISEASES 9812 \| KIAA0141 \| DISEASES 6193 \| RPS5 \| DISEASES 368 \| ABCC6 \| DISEASES 350 \| APOH \| DISEASES 8086 \| AAAS \| DISEASES 7049 \| TGFBR3 \| DISEASES 3053 \| SERPIND1 \| DISEASES 3162 \| HMOX1 \| DISEASES 10544 \| PROCR \| DISEASES 140679 \| SLC32A1 \| DISEASES 10857 \| PGRMC1 \| DISEASES 7076 \| TIMP1 \| DISEASES 4313 \| MMP2 \| DISEASES 5327 \| PLAT \| DISEASES 8797 \| TNFRSF10A \| DISEASES 2091 \| FBL \| DISEASES 973 \| CD79A \| DISEASES 5444 \| PON1 \| DISEASES 3082 \| HGF \| DISEASES 55033 \| FKBP14 \| DISEASES 5054 \| SERPINE1 \| DISEASES 23064 \| SETX \| DISEASES 657 \| BMPR1A \| DISEASES 4353 \| MPO \| DISEASES 1440 \| CSF3 \| DISEASES 6347 \| CCL2 \| DISEASES 51294 \| PCDH12 \| DISEASES 56920 \| SEMA3G \| DISEASES 338 \| APOB \| DISEASES 5657 \| PRTN3 \| DISEASES 335 \| APOA1 \| DISEASES 8600 \| TNFSF11 \| DISEASES 2703 \| GJA8 \| DISEASES 92 \| ACVR2A \| DISEASES 11328 \| FKBP9 \| DISEASES 56829 \| ZC3HAV1 \| DISEASES 6431 \| SRSF6 \| DISEASES 5184 \| PEPD \| DISEASES 10647 \| SCGB1D2 \| DISEASES 1948 \| EFNB2 \| DISEASES 6945 \| MLX \| DISEASES 821 \| CANX \| DISEASES 2658 \| GDF2 \| DISEASES 54567 \| DLL4 \| DISEASES 968 \| CD68 \| DISEASES 10053 \| AP1M2 \| DISEASES 1215 \| CMA1 \| DISEASES 3630 \| INS \| DISEASES 3040 \| HBA2 \| DISEASES 2006 \| ELN \| DISEASES 348 \| APOE \| DISEASES 341 \| APOC1 \| DISEASES 2056 \| EPO \| DISEASES 314 \| AOC2 \| DISEASES 6737 \| TRIM21 \| DISEASES 5176 \| SERPINF1 \| DISEASES 1401 \| CRP \| DISEASES 123811 \| FOPNL \| DISEASES 967 \| CD63 \| DISEASES 3569 \| IL6 \| DISEASES 6426 \| SRSF1 \| DISEASES 25833 \| POU2F3 \| DISEASES 7057 \| THBS1 \| DISEASES 6741 \| SSB \| DISEASES 7450 \| VWF \| DISEASES 2196 \| FAT2 \| DISEASES 4016 \| LOXL1 \| DISEASES 3690 \| ITGB3 \| DISEASES 23531 \| MMD \| DISEASES 8989 \| TRPA1 \| DISEASES 3674 \| ITGA2B \| DISEASES 64377 \| CHST8 \| DISEASES 25939 \| SAMHD1 \| DISEASES 54487 \| DGCR8 \| DISEASES 5024 \| P2RX3 \| DISEASES 3553 \| IL1B \| DISEASES 27143 \| PALD1 \| DISEASES 6403 \| SELP \| DISEASES 3791 \| KDR \| DISEASES 57514 \| ARHGAP31 \| DISEASES 54940 \| OCIAD1 \| DISEASES 2247 \| FGF2 \| DISEASES 3383 \| ICAM1 \| DISEASES 3827 \| KNG1 \| DISEASES 4683 \| NBN \| DISEASES 5286 \| PIK3C2A \| DISEASES 6017 \| RLBP1 \| DISEASES 207 \| AKT1 \| DISEASES 1762 \| DMWD \| DISEASES 57333 \| RCN3 \| DISEASES 64129 \| TINAGL1 \| DISEASES 5972 \| REN \| DISEASES 185 \| AGTR1 \| DISEASES 166378 \| SPATA5 \| DISEASES 5921 \| RASA1 \| DISEASES 472 \| ATM \| DISEASES 5281 \| PIGF \| DISEASES 2321 \| FLT1 \| DISEASES 3156 \| HMGCR \| DISEASES 22808 \| MRAS \| DISEASES 909 \| CD1A \| DISEASES 1636 \| ACE \| DISEASES 5739 \| PTGIR \| DISEASES 1409 \| CRYAA \| DISEASES 6294 \| SAFB \| DISEASES 1173 \| AP2M1 \| DISEASES 10630 \| PDPN \| DISEASES 57572 \| DOCK6 \| DISEASES 7412 \| VCAM1 \| DISEASES 27302 \| BMP10 \| DISEASES 285203 \| EOGT \| DISEASES 6051 \| RNPEP \| DISEASES 3490 \| IGFBP7 \| DISEASES 213 \| ALB \| DISEASES 5473 \| PPBP \| DISEASES 5196 \| PF4 \| DISEASES 7047 \| TGM4 \| DISEASES 3673 \| ITGA2 \| DISEASES 4982 \| TNFRSF11B \| DISEASES 115330 \| GPR146 \| DISEASES 4846 \| NOS3 \| DISEASES 120114 \| FAT3 \| DISEASES 4314 \| MMP3 \| DISEASES 4775 \| NFATC3 \| DISEASES 3816 \| KLK1 \| DISEASES 4054 \| LTBP3 \| DISEASES 51282 \| SCAND1 \| DISEASES 140838 \| NANP \| DISEASES 7343 \| UBTF \| DISEASES 3479 \| IGF1 \| DISEASES 83660 \| TLN2 \| DISEASES 136 \| ADORA2B \| DISEASES 1473 \| CST5 \| DISEASES 144125 \| OR2AG1 \| DISEASES 11280 \| SCN11A \| DISEASES 2147 \| F2 \| DISEASES 5340 \| PLG \| DISEASES 947 \| CD34 \| DISEASES 7423 \| VEGFB \| DISEASES 358 \| AQP1 \| DISEASES 8639 \| AOC3 \| DISEASES 285 \| ANGPT2 \| DISEASES 1909 \| EDNRA \| DISEASES 1191 \| CLU \| DISEASES 246213 \| SLC17A8 \| DISEASES 122664 \| TPPP2 \| DISEASES 1068 \| CETN1 \| DISEASES 7358 \| UGDH \| DISEASES 6863 \| TAC1 \| DISEASES 4018 \| LPA \| DISEASES 3996 \| LLGL1 \| DISEASES 5345 \| SERPINF2 \| DISEASES 64840 \| PORCN \| DISEASES 3039 \| HBA1 \| DISEASES 6330 \| SCN4B \| DISEASES 55511 \| SAGE1 \| DISEASES 3052 \| HCCS \| DISEASES 56478 \| EIF4ENIF1 \| DISEASES 254887 \| ZDHHC23 \| DISEASES 6401 \| SELE \| DISEASES 25987 \| TSKU \| DISEASES 286410 \| ATP11C \| DISEASES 3043 \| HBB \| DISEASES 2152 \| F3 \| DISEASES 27445 \| PCLO \| DISEASES 1058 \| CENPA \| DISEASES 1908 \| EDN3 \| DISEASES 375318 \| AQP12A \| DISEASES 4842 \| NOS1 \| DISEASES 3363 \| HTR7 \| DISEASES 3091 \| HIF1A \| DISEASES 2246 \| FGF1 \| DISEASES 155051 \| CRYGN \| DISEASES 2686 \| GGT7 \| DISEASES 57496 \| MKL2 \| DISEASES 3329 \| HSPD1 \| DISEASES 966 \| CD59 \| DISEASES 10755 \| GIPC1 \| DISEASES 4089 \| SMAD4 \| DISEASES 374393 \| FAM111B \| DISEASES 54345 \| SOX18 \| DISEASES 7137 \| TNNI3 \| DISEASES 3386 \| ICAM4 \| DISEASES 3146 \| HMGB1 \| DISEASES 51077 \| FCF1 \| DISEASES 875 \| CBS \| DISEASES 2534 \| FYN \| DISEASES 8654 \| PDE5A \| DISEASES 100506658 \| OCLN \| DISEASES 131601 \| TPRA1 \| DISEASES 26503 \| SLC17A5 \| DISEASES 3240 \| HP \| DISEASES 137902 \| PXDNL \| DISEASES 51367 \| POP5 \| DISEASES 54437 \| SEMA5B \| DISEASES 2005 \| ELK4 \| DISEASES 81031 \| SLC2A10 \| DISEASES 8936 \| WASF1 \| DISEASES 4151 \| MB \| DISEASES 2157 \| F8 \| DISEASES 578 \| BAK1 \| DISEASES 7150 \| TOP1 \| DISEASES 4860 \| PNP \| DISEASES 8556 \| CDC14A \| DISEASES 23038 \| WDTC1 \| DISEASES 22796 \| COG2 \| DISEASES 57165 \| GJC2 \| DISEASES 116841 \| SNAP47 \| DISEASES 7042 \| TGFB2 \| DISEASES 26254 \| OPTC \| DISEASES 7139 \| TNNT2 \| DISEASES 5788 \| PTPRC \| DISEASES 23418 \| CRB1 \| DISEASES 777 \| CACNA1E \| DISEASES 462 \| SERPINC1 \| DISEASES 2153 \| F5 \| DISEASES 336 \| APOA2 \| DISEASES 5824 \| PEX19 \| DISEASES 3766 \| KCNJ10 \| DISEASES 282991 \| BLOC1S2 \| DISEASES 2258 \| FGF13 \| DISEASES 959 \| CD40LG \| DISEASES 27022 \| FOXD3 \| DISEASES 8813 \| DPM1 \| DISEASES 7422 \| VEGFA \| DISEASES 4318 \| MMP9 \| DISEASES 25844 \| YIPF3 \| DISEASES 1907 \| EDN2 \| DISEASES 222642 \| TSPO2 \| DISEASES 2022 \| ENG \| DISEASES 7633 \| ZNF79 \| DISEASES 5292 \| PIM1 \| DISEASES 286205 \| SCAI \| DISEASES 4303 \| FOXO4 \| DISEASES 659 \| BMPR2 \| DISEASES 7046 \| TGFBR1 \| DISEASES 23569 \| PADI4 \| DISEASES 2155 \| F7 \| DISEASES 3055 \| HCK \| DISEASES 4879 \| NPPB \| DISEASES 4524 \| MTHFR \| DISEASES 3105 \| HLA-A \| DISEASES 5394 \| EXOSC10 \| DISEASES 6723 \| SRM \| DISEASES 7056 \| THBD \| DISEASES 1910 \| EDNRB \| DISEASES 6461 \| SHB \| DISEASES 11332 \| ACOT7 \| DISEASES 9356 \| SLC22A6 \| DISEASES 4693 \| NDP \| DISEASES 51182 \| HSPA14 \| DISEASES 2189 \| FANCG \| DISEASES 5251 \| PHEX \| DISEASES 1906 \| EDN1 \| DISEASES 5393 \| EXOSC9 \| DISEASES 1059 \| CENPB \| DISEASES 54840 \| APTX \| DISEASES 3717 \| JAK2 \| DISEASES 7436 \| VLDLR \| DISEASES 124220 \| ZG16B \| DISEASES 9875 \| URB1 \| DISEASES 94 \| ACVRL1 \| DISEASES 79001 \| VKORC1 \| DISEASES 6696 \| SPP1 \| DISEASES 93487 \| MAPK1IP1L \| DISEASES 4239 \| MFAP4 \| DISEASES 174 \| AFP \| DISEASES 6387 \| CXCL12 \| DISEASES 83989 \| FAM172A \| DISEASES 594857 \| NPS \| DISEASES 146198 \| ZFP90 \| DISEASES 7122 \| CLDN5 \| DISEASES 3778 \| KCNMA1 \| DISEASES 7018 \| TF \| DISEASES 4052 \| LTBP1 \| DISEASES 6335 \| SCN9A \| DISEASES 6336 \| SCN10A \| DISEASES 55273 \| TMEM100 \| DISEASES 23705 \| CADM1 \| DISEASES 10163 \| WASF2 \| DISEASES 7124 \| TNF \| DISEASES 387 \| RHOA \| DISEASES 91833 \| WDR20 \| DISEASES 8842 \| PROM1 \| DISEASES 133396 \| IL31RA \| DISEASES 1496 \| CTNNA2 \| DISEASES 10772 \| SRSF10 \| DISEASES 6949 \| TCOF1 \| DISEASES 56034 \| PDGFC \| DISEASES 7178 \| TPT1 \| DISEASES 3347 \| HTN3 \| DISEASES 26298 \| EHF \| DISEASES 83695 \| RHNO1 \| DISEASES 3684 \| ITGAM \| DISEASES 51303 \| FKBP11 \| DISEASES 5228 \| PGF \| DISEASES 6625 \| SNRNP70 \| DISEASES 100316868 \| HOTTIP \| DISEASES 102723508 \| KANTR \| DISEASES
Locus	(Waiting for update.)

Disease ID	496
Disease	peripheral vascular disease
Integrated Phenotype	(Waiting for update.)
Text Mined Phenotype	HPO \| Name \| Sentences' Count(Total Phenotypes:26) HP:0004417 \| Intermittent claudication \| 5 HP:0000819 \| Diabetes mellitus \| 5 HP:0012622 \| Chronic kidney disease \| 3 HP:0001297 \| Cerebral vascular events \| 3 HP:0004936 \| Blood clot in vein \| 2 HP:0000112 \| Nephropathy \| 2 HP:0012531 \| Pain \| 2 HP:0002625 \| Blood clot in a deep vein \| 2 HP:0002621 \| Atherosclerosis \| 2 HP:0030880 \| Raynaud phenomenon \| 1 HP:0003765 \| Psoriasis \| 1 HP:0001945 \| Fever \| 1 HP:0001513 \| Obesity \| 1 HP:0003774 \| End-stage renal failure \| 1 HP:0001677 \| Coronary artery disease \| 1 HP:0100758 \| Gangrene \| 1 HP:0001907 \| Thromboembolic disease \| 1 HP:0001650 \| Valvular aortic stenosis \| 1 HP:0100806 \| Sepsis \| 1 HP:0000716 \| Depression \| 1 HP:0000822 \| Hypertension \| 1 HP:0001658 \| Myocardial infarction \| 1 HP:0005978 \| Noninsulin dependent diabetes mellitus \| 1 HP:0000939 \| Osteoporosis \| 1 HP:0002666 \| Pheochromocytoma \| 1 HP:0000113 \| Polycystic kidney dysplasia \| 1

Disease ID	496
Disease	peripheral vascular disease
Manually Symptom	(Waiting for update.)
Text Mined Symptom	UMLS \| Name \| Sentences' Count(Total Symptoms:14) C1456822 \| claudication \| 9 C0021775 \| intermittent claudication \| 5 C0011849 \| diabetes mellitus \| 5 C0022116 \| ischemia \| 5 C0038454 \| stroke \| 3 C0030193 \| pain \| 2 C0149871 \| deep venous thrombosis \| 2 C0004153 \| atherosclerosis \| 2 C0017086 \| gangrene \| 1 C0010068 \| coronary artery disease \| 1 C1393529 \| vascular complications \| 1 C0021311 \| infections \| 1 C0009814 \| stenosis \| 1 C0234253 \| rest pain \| 1

Manually Genotype(Total Text Mining Genotypes:0)
(Waiting for update.)

All Snps(Total Genotypes:2)
snpId	pubmedId	geneId	geneSymbol	diseaseId	sourceId	sentence	score	Year	geneSymbol_dbSNP	CHROMOSOME	POS	REF	ALT
rs386626619	25345590	3717	JAK2	umls:C0085096	BeFree	Occurrence of the JAK2 V617F mutation in patients with peripheral arterial disease.	0.000271442	2014	NA	NA	NA	NA	NA
rs77375493	25345590	3717	JAK2	umls:C0085096	BeFree	Occurrence of the JAK2 V617F mutation in patients with peripheral arterial disease.	0.000271442	2014	JAK2;INSL6	9	5073770	G	A,T

GWASdb Annotation(Total Genotypes:0)
(Waiting for update.)

GWASdb Snp Trait(Total Genotypes:141)
CHR	POS	SNPID	REF	ALT	ORI_SNPID	PMID	P_VALUE	P_VALUE_TEXT	OR/BETA	CI95_TEXT	GWAS_INITIAL_SAMPLE_SIZE	SUB_POPULATION	SUPER_POPULATION	GWAS_TRAIT	HPO_ID	HPO_TERM	DO_ID	DO_TERM	MESH_ID	MESH_TERM	EFO_ID	EFO_TERM	DOLITE_TERM	RISK_ALLELE	PUBLICATION_TYPE	AA	GENE_SYMBOL	TYPE	REFGENE
1	2799480	rs11580768	C	T	rs11580768	22199011	3.85E-06	NA	NA	NA	41,692 European ancestry individuals	European(41692)	ALL(41692)	EUR(41692)	ALL(41692)	Ankle-brachial index	HPOID:0003028	Abnormality of the ankles	DOID:341	peripheral vascular disease	D055109	Ankle Brachial Index	EFOID:0003912	ankle brachial index	Vascular disease	NA	Research Support, N.I.H., Extramural	Meta-Analysis	Research Support, Non-U.S. Gov't
1	99687402	rs819797	G	A	rs819797	22199011	5.74E-06	NA	NA	NA	41,692 European ancestry individuals	European(41692)	ALL(41692)	EUR(41692)	ALL(41692)	Ankle-brachial index	HPOID:0003028	Abnormality of the ankles	DOID:341	peripheral vascular disease	D055109	Ankle Brachial Index	EFOID:0003912	ankle brachial index	Vascular disease	NA	Research Support, N.I.H., Extramural	Meta-Analysis	Research Support, Non-U.S. Gov't
1	99691732	rs7530667	T	C	rs7530667	22199011	8.43E-06	NA	NA	NA	41,692 European ancestry individuals	European(41692)	ALL(41692)	EUR(41692)	ALL(41692)	Ankle-brachial index	HPOID:0003028	Abnormality of the ankles	DOID:341	peripheral vascular disease	D055109	Ankle Brachial Index	EFOID:0003912	ankle brachial index	Vascular disease	NA	Research Support, N.I.H., Extramural	Meta-Analysis	Research Support, Non-U.S. Gov't
1	99693744	rs819746	C	A	rs819746	22199011	5.04E-06	NA	NA	NA	41,692 European ancestry individuals	European(41692)	ALL(41692)	EUR(41692)	ALL(41692)	Ankle-brachial index	HPOID:0003028	Abnormality of the ankles	DOID:341	peripheral vascular disease	D055109	Ankle Brachial Index	EFOID:0003912	ankle brachial index	Vascular disease	NA	Research Support, N.I.H., Extramural	Meta-Analysis	Research Support, Non-U.S. Gov't
1	99695168	rs819748	C	A	rs819748	22199011	4.19E-06	NA	NA	NA	41,692 European ancestry individuals	European(41692)	ALL(41692)	EUR(41692)	ALL(41692)	Ankle-brachial index	HPOID:0003028	Abnormality of the ankles	DOID:341	peripheral vascular disease	D055109	Ankle Brachial Index	EFOID:0003912	ankle brachial index	Vascular disease	NA	Research Support, N.I.H., Extramural	Meta-Analysis	Research Support, Non-U.S. Gov't
1	99697063	rs819750	G	T	rs819750	22199011	5.11E-04	NA	NA	NA	41,692 European ancestry individuals	European(41692)	ALL(41692)	EUR(41692)	ALL(41692)	Ankle-brachial index	HPOID:0003028	Abnormality of the ankles	DOID:341	peripheral vascular disease	D055109	Ankle Brachial Index	EFOID:0003912	ankle brachial index	Vascular disease	NA	Research Support, N.I.H., Extramural	Meta-Analysis	Research Support, Non-U.S. Gov't
1	99701930	rs819756	C	T	rs819756	22199011	9.71E-06	NA	NA	NA	41,692 European ancestry individuals	European(41692)	ALL(41692)	EUR(41692)	ALL(41692)	Ankle-brachial index	HPOID:0003028	Abnormality of the ankles	DOID:341	peripheral vascular disease	D055109	Ankle Brachial Index	EFOID:0003912	ankle brachial index	Vascular disease	NA	Research Support, N.I.H., Extramural	Meta-Analysis	Research Support, Non-U.S. Gov't
1	240846124	rs4659996	G	A	rs4659996	22199011	7.00E-06	NA	0	[0.0022-0.0058] unit decrease	41,692 European ancestry individuals	European(41692)	ALL(41692)	EUR(41692)	ALL(41692)	ankle-brachial index	HPOID:0003028	Abnormality of the ankles	DOID:341	peripheral vascular disease	D055109	Ankle Brachial Index	EFOID:0003912	ankle brachial index	Vascular disease	rs4659996-A	Research Support, N.I.H., Extramural	Meta-Analysis	Research Support, Non-U.S. Gov't
1	247012724	rs6426183	T	C	rs6426183	22199011	4.60E-06	NA	NA	NA	41,692 European ancestry individuals	European(41692)	ALL(41692)	EUR(41692)	ALL(41692)	Ankle-brachial index	HPOID:0003028	Abnormality of the ankles	DOID:341	peripheral vascular disease	D055109	Ankle Brachial Index	EFOID:0003912	ankle brachial index	Vascular disease	NA	Research Support, N.I.H., Extramural	Meta-Analysis	Research Support, Non-U.S. Gov't
2	211672061	rs16824978	C	T	rs16824978	22199011	7.77E-06	NA	NA	NA	41,692 European ancestry individuals	European(41692)	ALL(41692)	EUR(41692)	ALL(41692)	Ankle-brachial index	HPOID:0003028	Abnormality of the ankles	DOID:341	peripheral vascular disease	D055109	Ankle Brachial Index	EFOID:0003912	ankle brachial index	Vascular disease	NA	Research Support, N.I.H., Extramural	Meta-Analysis	Research Support, Non-U.S. Gov't
2	242511083	rs13004470	C	T	rs13004470	22361517	0.0000469	NA	NA	NA	21,550 European ancestry; 7,267 African American individuals	African American(7267)	European(21550)	ALL(28817)	AFR(7267)	EUR(21550)	ALL(28817)	Ankle-brachial index	HPOID:0003028	Abnormality of the ankles	DOID:341	peripheral vascular disease	D055109	Ankle Brachial Index	EFOID:0003912	ankle brachial index	Vascular disease	NA	Research Support, N.I.H., Extramural
3	31795570	rs1902341	C	T	rs1902341	20610895	5.00E-07	NA	1.31	[1.18-1.46]	195 Japanese cases; 1,358 Japanese controls	Japanese(1553)	ALL(1553)	ASN(1553)	ALL(1553)	Peripheral artery disease	HPOID:0004950	Peripheral arterial disease	DOID:341	peripheral vascular disease	D058729	Peripheral Arterial Disease	NA	NA	Vascular disease	rs1902341-G	Research Support, Non-U.S. Gov't	Comparative Study	G
3	113596992	rs2566977	C	A	rs2566977	22199011	9.04E-05	NA	NA	NA	41,692 European ancestry individuals	European(41692)	ALL(41692)	EUR(41692)	ALL(41692)	Ankle-brachial index	HPOID:0003028	Abnormality of the ankles	DOID:341	peripheral vascular disease	D055109	Ankle Brachial Index	EFOID:0003912	ankle brachial index	Vascular disease	NA	Research Support, N.I.H., Extramural	Meta-Analysis	Research Support, Non-U.S. Gov't
3	113600970	rs2245830	G	T	rs2245830	22199011	6.62E-05	NA	NA	NA	41,692 European ancestry individuals	European(41692)	ALL(41692)	EUR(41692)	ALL(41692)	Ankle-brachial index	HPOID:0003028	Abnormality of the ankles	DOID:341	peripheral vascular disease	D055109	Ankle Brachial Index	EFOID:0003912	ankle brachial index	Vascular disease	NA	Research Support, N.I.H., Extramural	Meta-Analysis	Research Support, Non-U.S. Gov't
3	113605375	rs2566973	T	C	rs2566973	22199011	6.99E-05	NA	NA	NA	41,692 European ancestry individuals	European(41692)	ALL(41692)	EUR(41692)	ALL(41692)	Ankle-brachial index	HPOID:0003028	Abnormality of the ankles	DOID:341	peripheral vascular disease	D055109	Ankle Brachial Index	EFOID:0003912	ankle brachial index	Vascular disease	NA	Research Support, N.I.H., Extramural	Meta-Analysis	Research Support, Non-U.S. Gov't
3	113606970	rs4682143	T	G	rs4682143	22199011	6.64E-05	NA	NA	NA	41,692 European ancestry individuals	European(41692)	ALL(41692)	EUR(41692)	ALL(41692)	Ankle-brachial index	HPOID:0003028	Abnormality of the ankles	DOID:341	peripheral vascular disease	D055109	Ankle Brachial Index	EFOID:0003912	ankle brachial index	Vascular disease	NA	Research Support, N.I.H., Extramural	Meta-Analysis	Research Support, Non-U.S. Gov't
3	113608975	rs6438172	A	G	rs6438172	22199011	6.56E-05	NA	NA	NA	41,692 European ancestry individuals	European(41692)	ALL(41692)	EUR(41692)	ALL(41692)	Ankle-brachial index	HPOID:0003028	Abnormality of the ankles	DOID:341	peripheral vascular disease	D055109	Ankle Brachial Index	EFOID:0003912	ankle brachial index	Vascular disease	NA	Research Support, N.I.H., Extramural	Meta-Analysis	Research Support, Non-U.S. Gov't
3	152867288	rs9830448	C	A	rs9830448	22361517	0.0000479	NA	NA	NA	21,550 European ancestry; 7,267 African American individuals	African American(7267)	European(21550)	ALL(28817)	AFR(7267)	EUR(21550)	ALL(28817)	Ankle-brachial index	HPOID:0003028	Abnormality of the ankles	DOID:341	peripheral vascular disease	D055109	Ankle Brachial Index	EFOID:0003912	ankle brachial index	Vascular disease	NA	Research Support, N.I.H., Extramural
3	177274479	rs11715199	C	G	rs11715199	22199011	4.89E-06	NA	NA	NA	41,692 European ancestry individuals	European(41692)	ALL(41692)	EUR(41692)	ALL(41692)	Ankle-brachial index	HPOID:0003028	Abnormality of the ankles	DOID:341	peripheral vascular disease	D055109	Ankle Brachial Index	EFOID:0003912	ankle brachial index	Vascular disease	NA	Research Support, N.I.H., Extramural	Meta-Analysis	Research Support, Non-U.S. Gov't
4	19088386	rs7696128	T	G	rs7696128	22199011	5.02E-06	NA	NA	NA	41,692 European ancestry individuals	European(41692)	ALL(41692)	EUR(41692)	ALL(41692)	Ankle-brachial index	HPOID:0003028	Abnormality of the ankles	DOID:341	peripheral vascular disease	D055109	Ankle Brachial Index	EFOID:0003912	ankle brachial index	Vascular disease	NA	Research Support, N.I.H., Extramural	Meta-Analysis	Research Support, Non-U.S. Gov't
4	87232984	rs11726269	A	G	rs11726269	25009551	2.00E-06	NA	1.39	[1.22-1.59]	1,641 European ancestry cases; 1,604 European ancestry controls	European(3245)	ALL(3245)	EUR(3245)	ALL(3245)	Peripheral artery disease	HPOID:0004950	Peripheral arterial disease	DOID:341	peripheral vascular disease	D058729	Peripheral Arterial Disease	NA	NA	Vascular disease	rs11726269-G	NA	A	MAPK10
4	162324862	rs9998941	G	A	rs9998941	22199011	6.00E-07	NA	NA	NA	41,692 European ancestry individuals	European(41692)	ALL(41692)	EUR(41692)	ALL(41692)	Ankle-brachial index	HPOID:0003028	Abnormality of the ankles	DOID:341	peripheral vascular disease	D055109	Ankle Brachial Index	EFOID:0003912	ankle brachial index	Vascular disease	NA	Research Support, N.I.H., Extramural	Meta-Analysis	Research Support, Non-U.S. Gov't
6	42643068	rs11751656	A	G	rs11751656	22199011	1.72E-06	NA	NA	NA	41,692 European ancestry individuals	European(41692)	ALL(41692)	EUR(41692)	ALL(41692)	Ankle-brachial index	HPOID:0003028	Abnormality of the ankles	DOID:341	peripheral vascular disease	D055109	Ankle Brachial Index	EFOID:0003912	ankle brachial index	Vascular disease	NA	Research Support, N.I.H., Extramural	Meta-Analysis	Research Support, Non-U.S. Gov't
6	102114780	rs9485528	A	G	rs9485528	22199011	4.63E-06	NA	NA	NA	41,692 European ancestry individuals	European(41692)	ALL(41692)	EUR(41692)	ALL(41692)	Ankle-brachial index	HPOID:0003028	Abnormality of the ankles	DOID:341	peripheral vascular disease	D055109	Ankle Brachial Index	EFOID:0003912	ankle brachial index	Vascular disease	NA	Research Support, N.I.H., Extramural	Meta-Analysis	Research Support, Non-U.S. Gov't
6	159183562	rs2171209	T	C	rs2171209	22361517	0.000000602	NA	NA	NA	21,550 European ancestry; 7,267 African American individuals	African American(7267)	European(21550)	ALL(28817)	AFR(7267)	EUR(21550)	ALL(28817)	Ankle-brachial index	HPOID:0003028	Abnormality of the ankles	DOID:341	peripheral vascular disease	D055109	Ankle Brachial Index	EFOID:0003912	ankle brachial index	Vascular disease	NA	Research Support, N.I.H., Extramural
6	160693107	rs3119311	T	C	rs3119311	22199011	5.54E-06	NA	NA	NA	41,692 European ancestry individuals	European(41692)	ALL(41692)	EUR(41692)	ALL(41692)	Ankle-brachial index	HPOID:0003028	Abnormality of the ankles	DOID:341	peripheral vascular disease	D055109	Ankle Brachial Index	EFOID:0003912	ankle brachial index	Vascular disease	NA	Research Support, N.I.H., Extramural	Meta-Analysis	Research Support, Non-U.S. Gov't
7	84199561	rs722453	A	G	rs722453	22199011	6.43E-06	NA	NA	NA	41,692 European ancestry individuals	European(41692)	ALL(41692)	EUR(41692)	ALL(41692)	Ankle-brachial index	HPOID:0003028	Abnormality of the ankles	DOID:341	peripheral vascular disease	D055109	Ankle Brachial Index	EFOID:0003912	ankle brachial index	Vascular disease	NA	Research Support, N.I.H., Extramural	Meta-Analysis	Research Support, Non-U.S. Gov't
7	84272193	rs7780912	A	G	rs7780912	22199011	6.57E-06	NA	NA	NA	41,692 European ancestry individuals	European(41692)	ALL(41692)	EUR(41692)	ALL(41692)	Ankle-brachial index	HPOID:0003028	Abnormality of the ankles	DOID:341	peripheral vascular disease	D055109	Ankle Brachial Index	EFOID:0003912	ankle brachial index	Vascular disease	NA	Research Support, N.I.H., Extramural	Meta-Analysis	Research Support, Non-U.S. Gov't
8	10253455	rs17151901	C	T	rs17151901	22361517	0.0000653	NA	NA	NA	21,550 European ancestry; 7,267 African American individuals	African American(7267)	European(21550)	ALL(28817)	AFR(7267)	EUR(21550)	ALL(28817)	Ankle-brachial index	HPOID:0003028	Abnormality of the ankles	DOID:341	peripheral vascular disease	D055109	Ankle Brachial Index	EFOID:0003912	ankle brachial index	Vascular disease	NA	Research Support, N.I.H., Extramural
8	41555473	rs2241896	T	C	rs2241896	22199011	9.99E-06	NA	NA	NA	41,692 European ancestry individuals	European(41692)	ALL(41692)	EUR(41692)	ALL(41692)	Ankle-brachial index	HPOID:0003028	Abnormality of the ankles	DOID:341	peripheral vascular disease	D055109	Ankle Brachial Index	EFOID:0003912	ankle brachial index	Vascular disease	NA	Research Support, N.I.H., Extramural	Meta-Analysis	Research Support, Non-U.S. Gov't
8	41581287	rs2099861	T	C	rs2099861	22199011	3.64E-06	NA	NA	NA	41,692 European ancestry individuals	European(41692)	ALL(41692)	EUR(41692)	ALL(41692)	Ankle-brachial index	HPOID:0003028	Abnormality of the ankles	DOID:341	peripheral vascular disease	D055109	Ankle Brachial Index	EFOID:0003912	ankle brachial index	Vascular disease	NA	Research Support, N.I.H., Extramural	Meta-Analysis	Research Support, Non-U.S. Gov't
8	41585571	rs1872877	C	T	rs1872877	22199011	4.66E-06	NA	NA	NA	41,692 European ancestry individuals	European(41692)	ALL(41692)	EUR(41692)	ALL(41692)	Ankle-brachial index	HPOID:0003028	Abnormality of the ankles	DOID:341	peripheral vascular disease	D055109	Ankle Brachial Index	EFOID:0003912	ankle brachial index	Vascular disease	NA	Research Support, N.I.H., Extramural	Meta-Analysis	Research Support, Non-U.S. Gov't
8	41586750	rs7003385	T	C	rs7003385	22199011	5.24E-07	NA	NA	NA	41,692 European ancestry individuals	European(41692)	ALL(41692)	EUR(41692)	ALL(41692)	Ankle-brachial index	HPOID:0003028	Abnormality of the ankles	DOID:341	peripheral vascular disease	D055109	Ankle Brachial Index	EFOID:0003912	ankle brachial index	Vascular disease	NA	Research Support, N.I.H., Extramural	Meta-Analysis	Research Support, Non-U.S. Gov't
8	41588186	rs2279437	A	G	rs2279437	22199011	5.69E-06	NA	NA	NA	41,692 European ancestry individuals	European(41692)	ALL(41692)	EUR(41692)	ALL(41692)	Ankle-brachial index	HPOID:0003028	Abnormality of the ankles	DOID:341	peripheral vascular disease	D055109	Ankle Brachial Index	EFOID:0003912	ankle brachial index	Vascular disease	NA	Research Support, N.I.H., Extramural	Meta-Analysis	Research Support, Non-U.S. Gov't
9	21997872	rs3218020	G	A	rs3218020	22199011	6.36E-07	NA	NA	NA	41,692 European ancestry individuals	European(41692)	ALL(41692)	EUR(41692)	ALL(41692)	Ankle-brachial index	HPOID:0003028	Abnormality of the ankles	DOID:341	peripheral vascular disease	D055109	Ankle Brachial Index	EFOID:0003912	ankle brachial index	Vascular disease	NA	Research Support, N.I.H., Extramural	Meta-Analysis	Research Support, Non-U.S. Gov't
9	22003367	rs1063192	G	A	rs1063192	22199011	3.82E-06	NA	NA	NA	41,692 European ancestry individuals	European(41692)	ALL(41692)	EUR(41692)	ALL(41692)	Ankle-brachial index	HPOID:0003028	Abnormality of the ankles	DOID:341	peripheral vascular disease	D055109	Ankle Brachial Index	EFOID:0003912	ankle brachial index	Vascular disease	NA	Research Support, N.I.H., Extramural	Meta-Analysis	Research Support, Non-U.S. Gov't
9	22009698	rs2069418	G	C	rs2069418	22199011	1.08E-06	NA	NA	NA	41,692 European ancestry individuals	European(41692)	ALL(41692)	EUR(41692)	ALL(41692)	Ankle-brachial index	HPOID:0003028	Abnormality of the ankles	DOID:341	peripheral vascular disease	D055109	Ankle Brachial Index	EFOID:0003912	ankle brachial index	Vascular disease	NA	Research Support, N.I.H., Extramural	Meta-Analysis	Research Support, Non-U.S. Gov't
9	22010004	rs2069416	T	A,G	rs2069416	22199011	2.37E-06	NA	NA	NA	41,692 European ancestry individuals	European(41692)	ALL(41692)	EUR(41692)	ALL(41692)	Ankle-brachial index	HPOID:0003028	Abnormality of the ankles	DOID:341	peripheral vascular disease	D055109	Ankle Brachial Index	EFOID:0003912	ankle brachial index	Vascular disease	NA	Research Support, N.I.H., Extramural	Meta-Analysis	Research Support, Non-U.S. Gov't
9	22013411	rs10811640	G	T	rs10811640	22199011	1.83E-06	NA	NA	NA	41,692 European ancestry individuals	European(41692)	ALL(41692)	EUR(41692)	ALL(41692)	Ankle-brachial index	HPOID:0003028	Abnormality of the ankles	DOID:341	peripheral vascular disease	D055109	Ankle Brachial Index	EFOID:0003912	ankle brachial index	Vascular disease	NA	Research Support, N.I.H., Extramural	Meta-Analysis	Research Support, Non-U.S. Gov't
9	22014137	rs10811641	C	G	rs10811641	22199011	2.14E-06	NA	NA	NA	41,692 European ancestry individuals	European(41692)	ALL(41692)	EUR(41692)	ALL(41692)	Ankle-brachial index	HPOID:0003028	Abnormality of the ankles	DOID:341	peripheral vascular disease	D055109	Ankle Brachial Index	EFOID:0003912	ankle brachial index	Vascular disease	NA	Research Support, N.I.H., Extramural	Meta-Analysis	Research Support, Non-U.S. Gov't
9	22017101	rs2106120	G	T	rs2106120	22199011	1.75E-06	NA	NA	NA	41,692 European ancestry individuals	European(41692)	ALL(41692)	EUR(41692)	ALL(41692)	Ankle-brachial index	HPOID:0003028	Abnormality of the ankles	DOID:341	peripheral vascular disease	D055109	Ankle Brachial Index	EFOID:0003912	ankle brachial index	Vascular disease	NA	Research Support, N.I.H., Extramural	Meta-Analysis	Research Support, Non-U.S. Gov't
9	22017550	rs2106119	A	G	rs2106119	22199011	1.76E-06	NA	NA	NA	41,692 European ancestry individuals	European(41692)	ALL(41692)	EUR(41692)	ALL(41692)	Ankle-brachial index	HPOID:0003028	Abnormality of the ankles	DOID:341	peripheral vascular disease	D055109	Ankle Brachial Index	EFOID:0003912	ankle brachial index	Vascular disease	NA	Research Support, N.I.H., Extramural	Meta-Analysis	Research Support, Non-U.S. Gov't
9	22018781	rs7044859	T	A	rs7044859	22199011	1.36E-06	NA	NA	NA	41,692 European ancestry individuals	European(41692)	ALL(41692)	EUR(41692)	ALL(41692)	Ankle-brachial index	HPOID:0003028	Abnormality of the ankles	DOID:341	peripheral vascular disease	D055109	Ankle Brachial Index	EFOID:0003912	ankle brachial index	Vascular disease	NA	Research Support, N.I.H., Extramural	Meta-Analysis	Research Support, Non-U.S. Gov't
9	22019129	rs523096	A	G	rs523096	22199011	3.36E-07	NA	NA	NA	41,692 European ancestry individuals	European(41692)	ALL(41692)	EUR(41692)	ALL(41692)	Ankle-brachial index	HPOID:0003028	Abnormality of the ankles	DOID:341	peripheral vascular disease	D055109	Ankle Brachial Index	EFOID:0003912	ankle brachial index	Vascular disease	NA	Research Support, N.I.H., Extramural	Meta-Analysis	Research Support, Non-U.S. Gov't
9	22019673	rs518394	G	C	rs518394	22199011	9.38E-06	NA	NA	NA	41,692 European ancestry individuals	European(41692)	ALL(41692)	EUR(41692)	ALL(41692)	Ankle-brachial index	HPOID:0003028	Abnormality of the ankles	DOID:341	peripheral vascular disease	D055109	Ankle Brachial Index	EFOID:0003912	ankle brachial index	Vascular disease	NA	Research Support, N.I.H., Extramural	Meta-Analysis	Research Support, Non-U.S. Gov't
9	22023795	rs10965212	T	A	rs10965212	22199011	4.85E-06	NA	NA	NA	41,692 European ancestry individuals	European(41692)	ALL(41692)	EUR(41692)	ALL(41692)	Ankle-brachial index	HPOID:0003028	Abnormality of the ankles	DOID:341	peripheral vascular disease	D055109	Ankle Brachial Index	EFOID:0003912	ankle brachial index	Vascular disease	NA	Research Support, N.I.H., Extramural	Meta-Analysis	Research Support, Non-U.S. Gov't
9	22025067	rs10811644	A	T	rs10811644	22199011	6.63E-07	NA	NA	NA	41,692 European ancestry individuals	European(41692)	ALL(41692)	EUR(41692)	ALL(41692)	Ankle-brachial index	HPOID:0003028	Abnormality of the ankles	DOID:341	peripheral vascular disease	D055109	Ankle Brachial Index	EFOID:0003912	ankle brachial index	Vascular disease	NA	Research Support, N.I.H., Extramural	Meta-Analysis	Research Support, Non-U.S. Gov't
9	22025240	rs7035484	C	G	rs7035484	22199011	6.86E-07	NA	NA	NA	41,692 European ancestry individuals	European(41692)	ALL(41692)	EUR(41692)	ALL(41692)	Ankle-brachial index	HPOID:0003028	Abnormality of the ankles	DOID:341	peripheral vascular disease	D055109	Ankle Brachial Index	EFOID:0003912	ankle brachial index	Vascular disease	NA	Research Support, N.I.H., Extramural	Meta-Analysis	Research Support, Non-U.S. Gov't
9	22025493	rs10738604	G	A	rs10738604	22199011	1.71E-07	NA	NA	NA	41,692 European ancestry individuals	European(41692)	ALL(41692)	EUR(41692)	ALL(41692)	Ankle-brachial index	HPOID:0003028	Abnormality of the ankles	DOID:341	peripheral vascular disease	D055109	Ankle Brachial Index	EFOID:0003912	ankle brachial index	Vascular disease	NA	Research Support, N.I.H., Extramural	Meta-Analysis	Research Support, Non-U.S. Gov't
9	22026077	rs615552	T	C	rs615552	22199011	1.52E-07	NA	NA	NA	41,692 European ancestry individuals	European(41692)	ALL(41692)	EUR(41692)	ALL(41692)	Ankle-brachial index	HPOID:0003028	Abnormality of the ankles	DOID:341	peripheral vascular disease	D055109	Ankle Brachial Index	EFOID:0003912	ankle brachial index	Vascular disease	NA	Research Support, N.I.H., Extramural	Meta-Analysis	Research Support, Non-U.S. Gov't
9	22026639	rs543830	A	T	rs543830	22199011	1.14E-06	NA	NA	NA	41,692 European ancestry individuals	European(41692)	ALL(41692)	EUR(41692)	ALL(41692)	Ankle-brachial index	HPOID:0003028	Abnormality of the ankles	DOID:341	peripheral vascular disease	D055109	Ankle Brachial Index	EFOID:0003912	ankle brachial index	Vascular disease	NA	Research Support, N.I.H., Extramural	Meta-Analysis	Research Support, Non-U.S. Gov't
9	22026834	rs1591136	G	C	rs1591136	22199011	6.85E-06	NA	NA	NA	41,692 European ancestry individuals	European(41692)	ALL(41692)	EUR(41692)	ALL(41692)	Ankle-brachial index	HPOID:0003028	Abnormality of the ankles	DOID:341	peripheral vascular disease	D055109	Ankle Brachial Index	EFOID:0003912	ankle brachial index	Vascular disease	NA	Research Support, N.I.H., Extramural	Meta-Analysis	Research Support, Non-U.S. Gov't
9	22028801	rs7049105	A	G	rs7049105	22199011	7.88E-06	NA	NA	NA	41,692 European ancestry individuals	European(41692)	ALL(41692)	EUR(41692)	ALL(41692)	Ankle-brachial index	HPOID:0003028	Abnormality of the ankles	DOID:341	peripheral vascular disease	D055109	Ankle Brachial Index	EFOID:0003912	ankle brachial index	Vascular disease	NA	Research Support, N.I.H., Extramural	Meta-Analysis	Research Support, Non-U.S. Gov't
9	22029080	rs679038	G	A	rs679038	22199011	1.26E-06	NA	NA	NA	41,692 European ancestry individuals	European(41692)	ALL(41692)	EUR(41692)	ALL(41692)	Ankle-brachial index	HPOID:0003028	Abnormality of the ankles	DOID:341	peripheral vascular disease	D055109	Ankle Brachial Index	EFOID:0003912	ankle brachial index	Vascular disease	NA	Research Support, N.I.H., Extramural	Meta-Analysis	Research Support, Non-U.S. Gov't
9	22029547	rs564398	T	C	rs564398	22199011	9.83E-07	NA	NA	NA	41,692 European ancestry individuals	European(41692)	ALL(41692)	EUR(41692)	ALL(41692)	Ankle-brachial index	HPOID:0003028	Abnormality of the ankles	DOID:341	peripheral vascular disease	D055109	Ankle Brachial Index	EFOID:0003912	ankle brachial index	Vascular disease	NA	Research Support, N.I.H., Extramural	Meta-Analysis	Research Support, Non-U.S. Gov't
9	22031005	rs7865618	G	A	rs7865618	22199011	1.08E-06	NA	NA	NA	41,692 European ancestry individuals	European(41692)	ALL(41692)	EUR(41692)	ALL(41692)	Ankle-brachial index	HPOID:0003028	Abnormality of the ankles	DOID:341	peripheral vascular disease	D055109	Ankle Brachial Index	EFOID:0003912	ankle brachial index	Vascular disease	NA	Research Support, N.I.H., Extramural	Meta-Analysis	Research Support, Non-U.S. Gov't
9	22032119	rs10115049	A	G	rs10115049	22199011	4.61E-06	NA	NA	NA	41,692 European ancestry individuals	European(41692)	ALL(41692)	EUR(41692)	ALL(41692)	Ankle-brachial index	HPOID:0003028	Abnormality of the ankles	DOID:341	peripheral vascular disease	D055109	Ankle Brachial Index	EFOID:0003912	ankle brachial index	Vascular disease	NA	Research Support, N.I.H., Extramural	Meta-Analysis	Research Support, Non-U.S. Gov't
9	22032152	rs634537	T	G	rs634537	22199011	1.01E-06	NA	NA	NA	41,692 European ancestry individuals	European(41692)	ALL(41692)	EUR(41692)	ALL(41692)	Ankle-brachial index	HPOID:0003028	Abnormality of the ankles	DOID:341	peripheral vascular disease	D055109	Ankle Brachial Index	EFOID:0003912	ankle brachial index	Vascular disease	NA	Research Support, N.I.H., Extramural	Meta-Analysis	Research Support, Non-U.S. Gov't
9	22033366	rs2157719	C	T	rs2157719	22199011	1.21E-06	NA	NA	NA	41,692 European ancestry individuals	European(41692)	ALL(41692)	EUR(41692)	ALL(41692)	Ankle-brachial index	HPOID:0003028	Abnormality of the ankles	DOID:341	peripheral vascular disease	D055109	Ankle Brachial Index	EFOID:0003912	ankle brachial index	Vascular disease	NA	Research Support, N.I.H., Extramural	Meta-Analysis	Research Support, Non-U.S. Gov't
9	22034719	rs2151280	G	A	rs2151280	22199011	6.73E-06	NA	NA	NA	41,692 European ancestry individuals	European(41692)	ALL(41692)	EUR(41692)	ALL(41692)	Ankle-brachial index	HPOID:0003028	Abnormality of the ankles	DOID:341	peripheral vascular disease	D055109	Ankle Brachial Index	EFOID:0003912	ankle brachial index	Vascular disease	NA	Research Support, N.I.H., Extramural	Meta-Analysis	Research Support, Non-U.S. Gov't
9	22036112	rs1008878	G	T	rs1008878	22199011	1.49E-06	NA	NA	NA	41,692 European ancestry individuals	European(41692)	ALL(41692)	EUR(41692)	ALL(41692)	Ankle-brachial index	HPOID:0003028	Abnormality of the ankles	DOID:341	peripheral vascular disease	D055109	Ankle Brachial Index	EFOID:0003912	ankle brachial index	Vascular disease	NA	Research Support, N.I.H., Extramural	Meta-Analysis	Research Support, Non-U.S. Gov't
9	22036367	rs1556515	C	T	rs1556515	22199011	2.48E-06	NA	NA	NA	41,692 European ancestry individuals	European(41692)	ALL(41692)	EUR(41692)	ALL(41692)	Ankle-brachial index	HPOID:0003028	Abnormality of the ankles	DOID:341	peripheral vascular disease	D055109	Ankle Brachial Index	EFOID:0003912	ankle brachial index	Vascular disease	NA	Research Support, N.I.H., Extramural	Meta-Analysis	Research Support, Non-U.S. Gov't
9	22040765	rs1333037	C	T	rs1333037	22199011	3.60E-06	NA	NA	NA	41,692 European ancestry individuals	European(41692)	ALL(41692)	EUR(41692)	ALL(41692)	Ankle-brachial index	HPOID:0003028	Abnormality of the ankles	DOID:341	peripheral vascular disease	D055109	Ankle Brachial Index	EFOID:0003912	ankle brachial index	Vascular disease	NA	Research Support, N.I.H., Extramural	Meta-Analysis	Research Support, Non-U.S. Gov't
9	22041443	rs1360590	T	C	rs1360590	22199011	6.81E-06	NA	NA	NA	41,692 European ancestry individuals	European(41692)	ALL(41692)	EUR(41692)	ALL(41692)	Ankle-brachial index	HPOID:0003028	Abnormality of the ankles	DOID:341	peripheral vascular disease	D055109	Ankle Brachial Index	EFOID:0003912	ankle brachial index	Vascular disease	NA	Research Support, N.I.H., Extramural	Meta-Analysis	Research Support, Non-U.S. Gov't
9	22043926	rs1412829	A	G	rs1412829	22199011	1.95E-06	NA	NA	NA	41,692 European ancestry individuals	European(41692)	ALL(41692)	EUR(41692)	ALL(41692)	Ankle-brachial index	HPOID:0003028	Abnormality of the ankles	DOID:341	peripheral vascular disease	D055109	Ankle Brachial Index	EFOID:0003912	ankle brachial index	Vascular disease	NA	Research Support, N.I.H., Extramural	Meta-Analysis	Research Support, Non-U.S. Gov't
9	22045317	rs1360589	C	T	rs1360589	22199011	4.62E-06	NA	NA	NA	41,692 European ancestry individuals	European(41692)	ALL(41692)	EUR(41692)	ALL(41692)	Ankle-brachial index	HPOID:0003028	Abnormality of the ankles	DOID:341	peripheral vascular disease	D055109	Ankle Brachial Index	EFOID:0003912	ankle brachial index	Vascular disease	NA	Research Support, N.I.H., Extramural	Meta-Analysis	Research Support, Non-U.S. Gov't
9	22048683	rs7028570	G	A	rs7028570	22199011	6.60E-06	NA	NA	NA	41,692 European ancestry individuals	European(41692)	ALL(41692)	EUR(41692)	ALL(41692)	Ankle-brachial index	HPOID:0003028	Abnormality of the ankles	DOID:341	peripheral vascular disease	D055109	Ankle Brachial Index	EFOID:0003912	ankle brachial index	Vascular disease	NA	Research Support, N.I.H., Extramural	Meta-Analysis	Research Support, Non-U.S. Gov't
9	22051670	rs944801	G	C	rs944801	22199011	5.80E-06	NA	NA	NA	41,692 European ancestry individuals	European(41692)	ALL(41692)	EUR(41692)	ALL(41692)	Ankle-brachial index	HPOID:0003028	Abnormality of the ankles	DOID:341	peripheral vascular disease	D055109	Ankle Brachial Index	EFOID:0003912	ankle brachial index	Vascular disease	NA	Research Support, N.I.H., Extramural	Meta-Analysis	Research Support, Non-U.S. Gov't
9	22053687	rs10965219	A	G	rs10965219	22199011	8.19E-06	NA	NA	NA	41,692 European ancestry individuals	European(41692)	ALL(41692)	EUR(41692)	ALL(41692)	Ankle-brachial index	HPOID:0003028	Abnormality of the ankles	DOID:341	peripheral vascular disease	D055109	Ankle Brachial Index	EFOID:0003912	ankle brachial index	Vascular disease	NA	Research Support, N.I.H., Extramural	Meta-Analysis	Research Support, Non-U.S. Gov't
9	22054040	rs7030641	C	T	rs7030641	22199011	5.68E-06	NA	NA	NA	41,692 European ancestry individuals	European(41692)	ALL(41692)	EUR(41692)	ALL(41692)	Ankle-brachial index	HPOID:0003028	Abnormality of the ankles	DOID:341	peripheral vascular disease	D055109	Ankle Brachial Index	EFOID:0003912	ankle brachial index	Vascular disease	NA	Research Support, N.I.H., Extramural	Meta-Analysis	Research Support, Non-U.S. Gov't
9	22056499	rs10120688	G	A	rs10120688	22199011	7.19E-06	NA	NA	NA	41,692 European ancestry individuals	European(41692)	ALL(41692)	EUR(41692)	ALL(41692)	Ankle-brachial index	HPOID:0003028	Abnormality of the ankles	DOID:341	peripheral vascular disease	D055109	Ankle Brachial Index	EFOID:0003912	ankle brachial index	Vascular disease	NA	Research Support, N.I.H., Extramural	Meta-Analysis	Research Support, Non-U.S. Gov't
9	22061614	rs1537378	A	G	rs1537378	22199011	8.49E-06	NA	NA	NA	41,692 European ancestry individuals	European(41692)	ALL(41692)	EUR(41692)	ALL(41692)	Ankle-brachial index	HPOID:0003028	Abnormality of the ankles	DOID:341	peripheral vascular disease	D055109	Ankle Brachial Index	EFOID:0003912	ankle brachial index	Vascular disease	NA	Research Support, N.I.H., Extramural	Meta-Analysis	Research Support, Non-U.S. Gov't
9	22064391	rs8181050	G	A	rs8181050	22199011	8.75E-06	NA	NA	NA	41,692 European ancestry individuals	European(41692)	ALL(41692)	EUR(41692)	ALL(41692)	Ankle-brachial index	HPOID:0003028	Abnormality of the ankles	DOID:341	peripheral vascular disease	D055109	Ankle Brachial Index	EFOID:0003912	ankle brachial index	Vascular disease	NA	Research Support, N.I.H., Extramural	Meta-Analysis	Research Support, Non-U.S. Gov't
9	22065002	rs10811647	C	G	rs10811647	22199011	8.39E-08	NA	NA	NA	41,692 European ancestry individuals	European(41692)	ALL(41692)	EUR(41692)	ALL(41692)	Ankle-brachial index	HPOID:0003028	Abnormality of the ankles	DOID:341	peripheral vascular disease	D055109	Ankle Brachial Index	EFOID:0003912	ankle brachial index	Vascular disease	NA	Research Support, N.I.H., Extramural	Meta-Analysis	Research Support, Non-U.S. Gov't
9	22065657	rs1333039	G	C	rs1333039	22199011	8.86E-06	NA	NA	NA	41,692 European ancestry individuals	European(41692)	ALL(41692)	EUR(41692)	ALL(41692)	Ankle-brachial index	HPOID:0003028	Abnormality of the ankles	DOID:341	peripheral vascular disease	D055109	Ankle Brachial Index	EFOID:0003912	ankle brachial index	Vascular disease	NA	Research Support, N.I.H., Extramural	Meta-Analysis	Research Support, Non-U.S. Gov't
9	22067276	rs10965224	T	A	rs10965224	22199011	8.13E-06	NA	NA	NA	41,692 European ancestry individuals	European(41692)	ALL(41692)	EUR(41692)	ALL(41692)	Ankle-brachial index	HPOID:0003028	Abnormality of the ankles	DOID:341	peripheral vascular disease	D055109	Ankle Brachial Index	EFOID:0003912	ankle brachial index	Vascular disease	NA	Research Support, N.I.H., Extramural	Meta-Analysis	Research Support, Non-U.S. Gov't
9	22067593	rs10811650	A	G	rs10811650	22199011	9.17E-08	NA	NA	NA	41,692 European ancestry individuals	European(41692)	ALL(41692)	EUR(41692)	ALL(41692)	Ankle-brachial index	HPOID:0003028	Abnormality of the ankles	DOID:341	peripheral vascular disease	D055109	Ankle Brachial Index	EFOID:0003912	ankle brachial index	Vascular disease	NA	Research Support, N.I.H., Extramural	Meta-Analysis	Research Support, Non-U.S. Gov't
9	22067830	rs10811651	G	A	rs10811651	22199011	9.22E-06	NA	NA	NA	41,692 European ancestry individuals	European(41692)	ALL(41692)	EUR(41692)	ALL(41692)	Ankle-brachial index	HPOID:0003028	Abnormality of the ankles	DOID:341	peripheral vascular disease	D055109	Ankle Brachial Index	EFOID:0003912	ankle brachial index	Vascular disease	NA	Research Support, N.I.H., Extramural	Meta-Analysis	Research Support, Non-U.S. Gov't
9	22068652	rs4977756	G	A	rs4977756	22199011	8.82E-06	NA	NA	NA	41,692 European ancestry individuals	European(41692)	ALL(41692)	EUR(41692)	ALL(41692)	Ankle-brachial index	HPOID:0003028	Abnormality of the ankles	DOID:341	peripheral vascular disease	D055109	Ankle Brachial Index	EFOID:0003912	ankle brachial index	Vascular disease	NA	Research Support, N.I.H., Extramural	Meta-Analysis	Research Support, Non-U.S. Gov't
9	22072264	rs10757269	A	G	rs10757269	22199011	9.00E-09	NA	0	[0.0029-0.0061] unit decrease	41,692 European ancestry individuals	European(41692)	ALL(41692)	EUR(41692)	ALL(41692)	ankle-brachial index	HPOID:0003028	Abnormality of the ankles	DOID:341	peripheral vascular disease	D055109	Ankle Brachial Index	EFOID:0003912	ankle brachial index	Vascular disease	rs10757269-G	Research Support, N.I.H., Extramural	Meta-Analysis	Research Support, Non-U.S. Gov't
9	22072301	rs9632884	G	C	rs9632884	22199011	2.89E-08	NA	NA	NA	41,692 European ancestry individuals	European(41692)	ALL(41692)	EUR(41692)	ALL(41692)	Ankle-brachial index	HPOID:0003028	Abnormality of the ankles	DOID:341	peripheral vascular disease	D055109	Ankle Brachial Index	EFOID:0003912	ankle brachial index	Vascular disease	NA	Research Support, N.I.H., Extramural	Meta-Analysis	Research Support, Non-U.S. Gov't
9	22081397	rs10116277	G	T	rs10116277	22199011	2.80E-07	NA	NA	NA	41,692 European ancestry individuals	European(41692)	ALL(41692)	EUR(41692)	ALL(41692)	Ankle-brachial index	HPOID:0003028	Abnormality of the ankles	DOID:341	peripheral vascular disease	D055109	Ankle Brachial Index	EFOID:0003912	ankle brachial index	Vascular disease	NA	Research Support, N.I.H., Extramural	Meta-Analysis	Research Support, Non-U.S. Gov't
9	22081850	rs6475606	C	T	rs6475606	22199011	2.43E-07	NA	NA	NA	41,692 European ancestry individuals	European(41692)	ALL(41692)	EUR(41692)	ALL(41692)	Ankle-brachial index	HPOID:0003028	Abnormality of the ankles	DOID:341	peripheral vascular disease	D055109	Ankle Brachial Index	EFOID:0003912	ankle brachial index	Vascular disease	NA	Research Support, N.I.H., Extramural	Meta-Analysis	Research Support, Non-U.S. Gov't
9	22084310	rs1537370	C	T	rs1537370	22199011	1.79E-06	NA	NA	NA	41,692 European ancestry individuals	European(41692)	ALL(41692)	EUR(41692)	ALL(41692)	Ankle-brachial index	HPOID:0003028	Abnormality of the ankles	DOID:341	peripheral vascular disease	D055109	Ankle Brachial Index	EFOID:0003912	ankle brachial index	Vascular disease	NA	Research Support, N.I.H., Extramural	Meta-Analysis	Research Support, Non-U.S. Gov't
9	22088094	rs10738607	A	G	rs10738607	22199011	1.60E-06	NA	NA	NA	41,692 European ancestry individuals	European(41692)	ALL(41692)	EUR(41692)	ALL(41692)	Ankle-brachial index	HPOID:0003028	Abnormality of the ankles	DOID:341	peripheral vascular disease	D055109	Ankle Brachial Index	EFOID:0003912	ankle brachial index	Vascular disease	NA	Research Support, N.I.H., Extramural	Meta-Analysis	Research Support, Non-U.S. Gov't
9	22088260	rs10757272	C	T	rs10757272	22199011	1.45E-06	NA	NA	NA	41,692 European ancestry individuals	European(41692)	ALL(41692)	EUR(41692)	ALL(41692)	Ankle-brachial index	HPOID:0003028	Abnormality of the ankles	DOID:341	peripheral vascular disease	D055109	Ankle Brachial Index	EFOID:0003912	ankle brachial index	Vascular disease	NA	Research Support, N.I.H., Extramural	Meta-Analysis	Research Support, Non-U.S. Gov't
9	22098574	rs4977574	A	G	rs4977574	22199011	2.33E-06	NA	NA	NA	41,692 European ancestry individuals	European(41692)	ALL(41692)	EUR(41692)	ALL(41692)	Ankle-brachial index	HPOID:0003028	Abnormality of the ankles	DOID:341	peripheral vascular disease	D055109	Ankle Brachial Index	EFOID:0003912	ankle brachial index	Vascular disease	NA	Research Support, N.I.H., Extramural	Meta-Analysis	Research Support, Non-U.S. Gov't
9	22098619	rs2891168	A	G	rs2891168	22199011	2.32E-06	NA	NA	NA	41,692 European ancestry individuals	European(41692)	ALL(41692)	EUR(41692)	ALL(41692)	Ankle-brachial index	HPOID:0003028	Abnormality of the ankles	DOID:341	peripheral vascular disease	D055109	Ankle Brachial Index	EFOID:0003912	ankle brachial index	Vascular disease	NA	Research Support, N.I.H., Extramural	Meta-Analysis	Research Support, Non-U.S. Gov't
9	22099568	rs1537371	C	A	rs1537371	22199011	1.93E-06	NA	NA	NA	41,692 European ancestry individuals	European(41692)	ALL(41692)	EUR(41692)	ALL(41692)	Ankle-brachial index	HPOID:0003028	Abnormality of the ankles	DOID:341	peripheral vascular disease	D055109	Ankle Brachial Index	EFOID:0003912	ankle brachial index	Vascular disease	NA	Research Support, N.I.H., Extramural	Meta-Analysis	Research Support, Non-U.S. Gov't
9	22100176	rs1556516	G	C	rs1556516	22199011	1.91E-06	NA	NA	NA	41,692 European ancestry individuals	European(41692)	ALL(41692)	EUR(41692)	ALL(41692)	Ankle-brachial index	HPOID:0003028	Abnormality of the ankles	DOID:341	peripheral vascular disease	D055109	Ankle Brachial Index	EFOID:0003912	ankle brachial index	Vascular disease	NA	Research Support, N.I.H., Extramural	Meta-Analysis	Research Support, Non-U.S. Gov't
9	22102165	rs7859727	C	T	rs7859727	22199011	2.19E-06	NA	NA	NA	41,692 European ancestry individuals	European(41692)	ALL(41692)	EUR(41692)	ALL(41692)	Ankle-brachial index	HPOID:0003028	Abnormality of the ankles	DOID:341	peripheral vascular disease	D055109	Ankle Brachial Index	EFOID:0003912	ankle brachial index	Vascular disease	NA	Research Support, N.I.H., Extramural	Meta-Analysis	Research Support, Non-U.S. Gov't
9	22103341	rs1537373	T	G	rs1537373	22199011	2.28E-06	NA	NA	NA	41,692 European ancestry individuals	European(41692)	ALL(41692)	EUR(41692)	ALL(41692)	Ankle-brachial index	HPOID:0003028	Abnormality of the ankles	DOID:341	peripheral vascular disease	D055109	Ankle Brachial Index	EFOID:0003912	ankle brachial index	Vascular disease	NA	Research Support, N.I.H., Extramural	Meta-Analysis	Research Support, Non-U.S. Gov't
9	22103813	rs1333042	A	G	rs1333042	22199011	2.15E-07	NA	NA	NA	41,692 European ancestry individuals	European(41692)	ALL(41692)	EUR(41692)	ALL(41692)	Ankle-brachial index	HPOID:0003028	Abnormality of the ankles	DOID:341	peripheral vascular disease	D055109	Ankle Brachial Index	EFOID:0003912	ankle brachial index	Vascular disease	NA	Research Support, N.I.H., Extramural	Meta-Analysis	Research Support, Non-U.S. Gov't
9	22105927	rs7859362	T	C	rs7859362	22199011	2.10E-07	NA	NA	NA	41,692 European ancestry individuals	European(41692)	ALL(41692)	EUR(41692)	ALL(41692)	Ankle-brachial index	HPOID:0003028	Abnormality of the ankles	DOID:341	peripheral vascular disease	D055109	Ankle Brachial Index	EFOID:0003912	ankle brachial index	Vascular disease	NA	Research Support, N.I.H., Extramural	Meta-Analysis	Research Support, Non-U.S. Gov't
9	22106731	rs1333043	T	A	rs1333043	22199011	8.00E-07	NA	NA	NA	41,692 European ancestry individuals	European(41692)	ALL(41692)	EUR(41692)	ALL(41692)	Ankle-brachial index	HPOID:0003028	Abnormality of the ankles	DOID:341	peripheral vascular disease	D055109	Ankle Brachial Index	EFOID:0003912	ankle brachial index	Vascular disease	NA	Research Support, N.I.H., Extramural	Meta-Analysis	Research Support, Non-U.S. Gov't
9	22110131	rs1412834	T	C	rs1412834	22199011	2.10E-07	NA	NA	NA	41,692 European ancestry individuals	European(41692)	ALL(41692)	EUR(41692)	ALL(41692)	Ankle-brachial index	HPOID:0003028	Abnormality of the ankles	DOID:341	peripheral vascular disease	D055109	Ankle Brachial Index	EFOID:0003912	ankle brachial index	Vascular disease	NA	Research Support, N.I.H., Extramural	Meta-Analysis	Research Support, Non-U.S. Gov't
9	22112241	rs7341786	A	C	rs7341786	22199011	1.46E-07	NA	NA	NA	41,692 European ancestry individuals	European(41692)	ALL(41692)	EUR(41692)	ALL(41692)	Ankle-brachial index	HPOID:0003028	Abnormality of the ankles	DOID:341	peripheral vascular disease	D055109	Ankle Brachial Index	EFOID:0003912	ankle brachial index	Vascular disease	NA	Research Support, N.I.H., Extramural	Meta-Analysis	Research Support, Non-U.S. Gov't
9	22112599	rs10511701	T	C	rs10511701	22199011	1.46E-07	NA	NA	NA	41,692 European ancestry individuals	European(41692)	ALL(41692)	EUR(41692)	ALL(41692)	Ankle-brachial index	HPOID:0003028	Abnormality of the ankles	DOID:341	peripheral vascular disease	D055109	Ankle Brachial Index	EFOID:0003912	ankle brachial index	Vascular disease	NA	Research Support, N.I.H., Extramural	Meta-Analysis	Research Support, Non-U.S. Gov't
9	22114469	rs10733376	G	C	rs10733376	22199011	1.79E-07	NA	NA	NA	41,692 European ancestry individuals	European(41692)	ALL(41692)	EUR(41692)	ALL(41692)	Ankle-brachial index	HPOID:0003028	Abnormality of the ankles	DOID:341	peripheral vascular disease	D055109	Ankle Brachial Index	EFOID:0003912	ankle brachial index	Vascular disease	NA	Research Support, N.I.H., Extramural	Meta-Analysis	Research Support, Non-U.S. Gov't
9	22114495	rs10738609	A	C,G,T	rs10738609	22199011	1.79E-07	NA	NA	NA	41,692 European ancestry individuals	European(41692)	ALL(41692)	EUR(41692)	ALL(41692)	Ankle-brachial index	HPOID:0003028	Abnormality of the ankles	DOID:341	peripheral vascular disease	D055109	Ankle Brachial Index	EFOID:0003912	ankle brachial index	Vascular disease	NA	Research Support, N.I.H., Extramural	Meta-Analysis	Research Support, Non-U.S. Gov't
9	22115026	rs2383206	A	G	rs2383206	22199011	1.77E-07	NA	NA	NA	41,692 European ancestry individuals	European(41692)	ALL(41692)	EUR(41692)	ALL(41692)	Ankle-brachial index	HPOID:0003028	Abnormality of the ankles	DOID:341	peripheral vascular disease	D055109	Ankle Brachial Index	EFOID:0003912	ankle brachial index	Vascular disease	NA	Research Support, N.I.H., Extramural	Meta-Analysis	Research Support, Non-U.S. Gov't
9	22115286	rs944797	T	C	rs944797	22199011	1.45E-07	NA	NA	NA	41,692 European ancestry individuals	European(41692)	ALL(41692)	EUR(41692)	ALL(41692)	Ankle-brachial index	HPOID:0003028	Abnormality of the ankles	DOID:341	peripheral vascular disease	D055109	Ankle Brachial Index	EFOID:0003912	ankle brachial index	Vascular disease	NA	Research Support, N.I.H., Extramural	Meta-Analysis	Research Support, Non-U.S. Gov't
9	22115589	rs1004638	A	T	rs1004638	22199011	1.43E-07	NA	NA	NA	41,692 European ancestry individuals	European(41692)	ALL(41692)	EUR(41692)	ALL(41692)	Ankle-brachial index	HPOID:0003028	Abnormality of the ankles	DOID:341	peripheral vascular disease	D055109	Ankle Brachial Index	EFOID:0003912	ankle brachial index	Vascular disease	NA	Research Support, N.I.H., Extramural	Meta-Analysis	Research Support, Non-U.S. Gov't
9	22115959	rs2383207	A	G	rs2383207	22199011	1.12E-07	NA	NA	NA	41,692 European ancestry individuals	European(41692)	ALL(41692)	EUR(41692)	ALL(41692)	Ankle-brachial index	HPOID:0003028	Abnormality of the ankles	DOID:341	peripheral vascular disease	D055109	Ankle Brachial Index	EFOID:0003912	ankle brachial index	Vascular disease	NA	Research Support, N.I.H., Extramural	Meta-Analysis	Research Support, Non-U.S. Gov't
9	22116046	rs1537374	A	G	rs1537374	22199011	1.22E-07	NA	NA	NA	41,692 European ancestry individuals	European(41692)	ALL(41692)	EUR(41692)	ALL(41692)	Ankle-brachial index	HPOID:0003028	Abnormality of the ankles	DOID:341	peripheral vascular disease	D055109	Ankle Brachial Index	EFOID:0003912	ankle brachial index	Vascular disease	NA	Research Support, N.I.H., Extramural	Meta-Analysis	Research Support, Non-U.S. Gov't
9	22116071	rs1537375	T	C	rs1537375	22199011	1.06E-07	NA	NA	NA	41,692 European ancestry individuals	European(41692)	ALL(41692)	EUR(41692)	ALL(41692)	Ankle-brachial index	HPOID:0003028	Abnormality of the ankles	DOID:341	peripheral vascular disease	D055109	Ankle Brachial Index	EFOID:0003912	ankle brachial index	Vascular disease	NA	Research Support, N.I.H., Extramural	Meta-Analysis	Research Support, Non-U.S. Gov't
9	22123766	rs10738610	A	C	rs10738610	22199011	1.87E-07	NA	NA	NA	41,692 European ancestry individuals	European(41692)	ALL(41692)	EUR(41692)	ALL(41692)	Ankle-brachial index	HPOID:0003028	Abnormality of the ankles	DOID:341	peripheral vascular disease	D055109	Ankle Brachial Index	EFOID:0003912	ankle brachial index	Vascular disease	NA	Research Support, N.I.H., Extramural	Meta-Analysis	Research Support, Non-U.S. Gov't
9	22124123	rs1333046	T	A	rs1333046	22199011	1.91E-07	NA	NA	NA	41,692 European ancestry individuals	European(41692)	ALL(41692)	EUR(41692)	ALL(41692)	Ankle-brachial index	HPOID:0003028	Abnormality of the ankles	DOID:341	peripheral vascular disease	D055109	Ankle Brachial Index	EFOID:0003912	ankle brachial index	Vascular disease	NA	Research Support, N.I.H., Extramural	Meta-Analysis	Research Support, Non-U.S. Gov't
9	22124477	rs10757278	A	G	rs10757278	22199011	4.43E-06	NA	NA	NA	41,692 European ancestry individuals	European(41692)	ALL(41692)	EUR(41692)	ALL(41692)	Ankle-brachial index	HPOID:0003028	Abnormality of the ankles	DOID:341	peripheral vascular disease	D055109	Ankle Brachial Index	EFOID:0003912	ankle brachial index	Vascular disease	NA	Research Support, N.I.H., Extramural	Meta-Analysis	Research Support, Non-U.S. Gov't
9	22124504	rs1333047	A	T	rs1333047	22199011	4.47E-06	NA	NA	NA	41,692 European ancestry individuals	European(41692)	ALL(41692)	EUR(41692)	ALL(41692)	Ankle-brachial index	HPOID:0003028	Abnormality of the ankles	DOID:341	peripheral vascular disease	D055109	Ankle Brachial Index	EFOID:0003912	ankle brachial index	Vascular disease	NA	Research Support, N.I.H., Extramural	Meta-Analysis	Research Support, Non-U.S. Gov't
9	22124744	rs4977575	C	G	rs4977575	22199011	5.47E-06	NA	NA	NA	41,692 European ancestry individuals	European(41692)	ALL(41692)	EUR(41692)	ALL(41692)	Ankle-brachial index	HPOID:0003028	Abnormality of the ankles	DOID:341	peripheral vascular disease	D055109	Ankle Brachial Index	EFOID:0003912	ankle brachial index	Vascular disease	NA	Research Support, N.I.H., Extramural	Meta-Analysis	Research Support, Non-U.S. Gov't
9	22125347	rs1333048	A	C	rs1333048	22199011	1.50E-06	NA	NA	NA	41,692 European ancestry individuals	European(41692)	ALL(41692)	EUR(41692)	ALL(41692)	Ankle-brachial index	HPOID:0003028	Abnormality of the ankles	DOID:341	peripheral vascular disease	D055109	Ankle Brachial Index	EFOID:0003912	ankle brachial index	Vascular disease	NA	Research Support, N.I.H., Extramural	Meta-Analysis	Research Support, Non-U.S. Gov't
9	22125503	rs1333049	G	C	rs1333049	22199011	5.51E-06	NA	NA	NA	41,692 European ancestry individuals	European(41692)	ALL(41692)	EUR(41692)	ALL(41692)	Ankle-brachial index	HPOID:0003028	Abnormality of the ankles	DOID:341	peripheral vascular disease	D055109	Ankle Brachial Index	EFOID:0003912	ankle brachial index	Vascular disease	NA	Research Support, N.I.H., Extramural	Meta-Analysis	Research Support, Non-U.S. Gov't
9	124487495	rs13290547	C	T	rs13290547	22199011	3.62E-05	NA	NA	NA	41,692 European ancestry individuals	European(41692)	ALL(41692)	EUR(41692)	ALL(41692)	Ankle-brachial index	HPOID:0003028	Abnormality of the ankles	DOID:341	peripheral vascular disease	D055109	Ankle Brachial Index	EFOID:0003912	ankle brachial index	Vascular disease	NA	Research Support, N.I.H., Extramural	Meta-Analysis	Research Support, Non-U.S. Gov't
10	20899608	rs2359536	T	C	rs2359536	20610895	2.00E-06	NA	1.84	[1.43-2.37]	195 Japanese cases; 1,358 Japanese controls	Japanese(1553)	ALL(1553)	ASN(1553)	ALL(1553)	Peripheral artery disease	HPOID:0004950	Peripheral arterial disease	DOID:341	peripheral vascular disease	D058729	Peripheral Arterial Disease	NA	NA	Vascular disease	rs2359536-C	Research Support, Non-U.S. Gov't	Comparative Study	T
10	82708724	rs12772949	A	G	rs12772949	22199011	2.14E-06	NA	NA	NA	41,692 European ancestry individuals	European(41692)	ALL(41692)	EUR(41692)	ALL(41692)	Ankle-brachial index	HPOID:0003028	Abnormality of the ankles	DOID:341	peripheral vascular disease	D055109	Ankle Brachial Index	EFOID:0003912	ankle brachial index	Vascular disease	NA	Research Support, N.I.H., Extramural	Meta-Analysis	Research Support, Non-U.S. Gov't
10	94224165	rs1887922	C	T	rs1887922	22199011	9.74E-05	NA	NA	NA	41,692 European ancestry individuals	European(41692)	ALL(41692)	EUR(41692)	ALL(41692)	Ankle-brachial index	HPOID:0003028	Abnormality of the ankles	DOID:341	peripheral vascular disease	D055109	Ankle Brachial Index	EFOID:0003912	ankle brachial index	Vascular disease	NA	Research Support, N.I.H., Extramural	Meta-Analysis	Research Support, Non-U.S. Gov't
10	94249769	rs7093418	T	G	rs7093418	22199011	6.69E-05	NA	NA	NA	41,692 European ancestry individuals	European(41692)	ALL(41692)	EUR(41692)	ALL(41692)	Ankle-brachial index	HPOID:0003028	Abnormality of the ankles	DOID:341	peripheral vascular disease	D055109	Ankle Brachial Index	EFOID:0003912	ankle brachial index	Vascular disease	NA	Research Support, N.I.H., Extramural	Meta-Analysis	Research Support, Non-U.S. Gov't
10	94254283	rs1855916	A	G	rs1855916	22199011	5.87E-05	NA	NA	NA	41,692 European ancestry individuals	European(41692)	ALL(41692)	EUR(41692)	ALL(41692)	Ankle-brachial index	HPOID:0003028	Abnormality of the ankles	DOID:341	peripheral vascular disease	D055109	Ankle Brachial Index	EFOID:0003912	ankle brachial index	Vascular disease	NA	Research Support, N.I.H., Extramural	Meta-Analysis	Research Support, Non-U.S. Gov't
10	94257218	rs7084090	A	T	rs7084090	22199011	5.93E-05	NA	NA	NA	41,692 European ancestry individuals	European(41692)	ALL(41692)	EUR(41692)	ALL(41692)	Ankle-brachial index	HPOID:0003028	Abnormality of the ankles	DOID:341	peripheral vascular disease	D055109	Ankle Brachial Index	EFOID:0003912	ankle brachial index	Vascular disease	NA	Research Support, N.I.H., Extramural	Meta-Analysis	Research Support, Non-U.S. Gov't
10	94295316	rs7898493	C	G	rs7898493	22199011	3.67E-05	NA	NA	NA	41,692 European ancestry individuals	European(41692)	ALL(41692)	EUR(41692)	ALL(41692)	Ankle-brachial index	HPOID:0003028	Abnormality of the ankles	DOID:341	peripheral vascular disease	D055109	Ankle Brachial Index	EFOID:0003912	ankle brachial index	Vascular disease	NA	Research Support, N.I.H., Extramural	Meta-Analysis	Research Support, Non-U.S. Gov't
10	94314804	rs7908111	A	G	rs7908111	22199011	3.22E-05	NA	NA	NA	41,692 European ancestry individuals	European(41692)	ALL(41692)	EUR(41692)	ALL(41692)	Ankle-brachial index	HPOID:0003028	Abnormality of the ankles	DOID:341	peripheral vascular disease	D055109	Ankle Brachial Index	EFOID:0003912	ankle brachial index	Vascular disease	NA	Research Support, N.I.H., Extramural	Meta-Analysis	Research Support, Non-U.S. Gov't
10	94326946	rs11187074	C	G	rs11187074	22199011	5.64E-05	NA	NA	NA	41,692 European ancestry individuals	European(41692)	ALL(41692)	EUR(41692)	ALL(41692)	Ankle-brachial index	HPOID:0003028	Abnormality of the ankles	DOID:341	peripheral vascular disease	D055109	Ankle Brachial Index	EFOID:0003912	ankle brachial index	Vascular disease	NA	Research Support, N.I.H., Extramural	Meta-Analysis	Research Support, Non-U.S. Gov't
10	94327156	rs7100623	T	C	rs7100623	22199011	1.89E-05	NA	NA	NA	41,692 European ancestry individuals	European(41692)	ALL(41692)	EUR(41692)	ALL(41692)	Ankle-brachial index	HPOID:0003028	Abnormality of the ankles	DOID:341	peripheral vascular disease	D055109	Ankle Brachial Index	EFOID:0003912	ankle brachial index	Vascular disease	NA	Research Support, N.I.H., Extramural	Meta-Analysis	Research Support, Non-U.S. Gov't
10	95528442	rs10509665	G	A	rs10509665	22199011	5.99E-06	NA	NA	NA	41,692 European ancestry individuals	European(41692)	ALL(41692)	EUR(41692)	ALL(41692)	Ankle-brachial index	HPOID:0003028	Abnormality of the ankles	DOID:341	peripheral vascular disease	D055109	Ankle Brachial Index	EFOID:0003912	ankle brachial index	Vascular disease	NA	Research Support, N.I.H., Extramural	Meta-Analysis	Research Support, Non-U.S. Gov't
10	114923825	rs290481	C	T	rs290481	22361517	0.000000701	NA	NA	NA	21,550 European ancestry; 7,267 African American individuals	African American(7267)	European(21550)	ALL(28817)	AFR(7267)	EUR(21550)	ALL(28817)	Ankle-brachial index	HPOID:0003028	Abnormality of the ankles	DOID:341	peripheral vascular disease	D055109	Ankle Brachial Index	EFOID:0003912	ankle brachial index	Vascular disease	NA	Research Support, N.I.H., Extramural
12	95249995	rs10507044	C	T	rs10507044	22199011	7.25E-06	NA	NA	NA	41,692 European ancestry individuals	European(41692)	ALL(41692)	EUR(41692)	ALL(41692)	Ankle-brachial index	HPOID:0003028	Abnormality of the ankles	DOID:341	peripheral vascular disease	D055109	Ankle Brachial Index	EFOID:0003912	ankle brachial index	Vascular disease	NA	Research Support, N.I.H., Extramural	Meta-Analysis	Research Support, Non-U.S. Gov't
12	96335003	rs7311009	C	G	rs7311009	22199011	8.94E-06	NA	NA	NA	41,692 European ancestry individuals	European(41692)	ALL(41692)	EUR(41692)	ALL(41692)	Ankle-brachial index	HPOID:0003028	Abnormality of the ankles	DOID:341	peripheral vascular disease	D055109	Ankle Brachial Index	EFOID:0003912	ankle brachial index	Vascular disease	NA	Research Support, N.I.H., Extramural	Meta-Analysis	Research Support, Non-U.S. Gov't
12	96423782	rs2660896	T	C	rs2660896	22361517	0.0000794	NA	NA	NA	21,550 European ancestry; 7,267 African American individuals	African American(7267)	European(21550)	ALL(28817)	AFR(7267)	EUR(21550)	ALL(28817)	Ankle-brachial index	HPOID:0003028	Abnormality of the ankles	DOID:341	peripheral vascular disease	D055109	Ankle Brachial Index	EFOID:0003912	ankle brachial index	Vascular disease	NA	Research Support, N.I.H., Extramural
12	112007756	rs653178	C	T	rs653178	25009551	6.00E-07	NA	1.22	[1.13-1.32]	1,641 European ancestry cases; 1,604 European ancestry controls	European(3245)	ALL(3245)	EUR(3245)	ALL(3245)	Peripheral artery disease	HPOID:0004950	Peripheral arterial disease	DOID:341	peripheral vascular disease	D058729	Peripheral Arterial Disease	NA	NA	Vascular disease	rs653178-C	NA	A	ATXN2
12	131569105	rs11061318	C	T	rs11061318	22361517	0.00000446	NA	NA	NA	21,550 European ancestry; 7,267 African American individuals	African American(7267)	European(21550)	ALL(28817)	AFR(7267)	EUR(21550)	ALL(28817)	Ankle-brachial index	HPOID:0003028	Abnormality of the ankles	DOID:341	peripheral vascular disease	D055109	Ankle Brachial Index	EFOID:0003912	ankle brachial index	Vascular disease	NA	Research Support, N.I.H., Extramural
13	110902292	rs12428227	A	G	rs12428227	22361517	0.000052	NA	NA	NA	21,550 European ancestry; 7,267 African American individuals	African American(7267)	European(21550)	ALL(28817)	AFR(7267)	EUR(21550)	ALL(28817)	Ankle-brachial index	HPOID:0003028	Abnormality of the ankles	DOID:341	peripheral vascular disease	D055109	Ankle Brachial Index	EFOID:0003912	ankle brachial index	Vascular disease	NA	Research Support, N.I.H., Extramural
14	64911627	rs1256143	T	C	rs1256143	22361517	0.0000143	NA	NA	NA	21,550 European ancestry; 7,267 African American individuals	African American(7267)	European(21550)	ALL(28817)	AFR(7267)	EUR(21550)	ALL(28817)	Ankle-brachial index	HPOID:0003028	Abnormality of the ankles	DOID:341	peripheral vascular disease	D055109	Ankle Brachial Index	EFOID:0003912	ankle brachial index	Vascular disease	NA	Research Support, N.I.H., Extramural
16	75574030	rs2242406	C	T	rs2242406	22361517	0.0000946	NA	NA	NA	21,550 European ancestry; 7,267 African American individuals	African American(7267)	European(21550)	ALL(28817)	AFR(7267)	EUR(21550)	ALL(28817)	Ankle-brachial index	HPOID:0003028	Abnormality of the ankles	DOID:341	peripheral vascular disease	D055109	Ankle Brachial Index	EFOID:0003912	ankle brachial index	Vascular disease	NA	Research Support, N.I.H., Extramural
17	216763	rs4366776	C	T	rs4366776	22199011	4.52E-06	NA	NA	NA	41,692 European ancestry individuals	European(41692)	ALL(41692)	EUR(41692)	ALL(41692)	Ankle-brachial index	HPOID:0003028	Abnormality of the ankles	DOID:341	peripheral vascular disease	D055109	Ankle Brachial Index	EFOID:0003912	ankle brachial index	Vascular disease	NA	Research Support, N.I.H., Extramural	Meta-Analysis	Research Support, Non-U.S. Gov't
17	4835895	rs2243093	T	C	rs2243093	22361517	0.0000594	NA	NA	NA	21,550 European ancestry; 7,267 African American individuals	African American(7267)	European(21550)	ALL(28817)	AFR(7267)	EUR(21550)	ALL(28817)	Ankle-brachial index	HPOID:0003028	Abnormality of the ankles	DOID:341	peripheral vascular disease	D055109	Ankle Brachial Index	EFOID:0003912	ankle brachial index	Vascular disease	NA	Research Support, N.I.H., Extramural
17	4839033	rs2243100	C	T	rs2243100	22361517	0.00005	NA	NA	NA	21,550 European ancestry; 7,267 African American individuals	African American(7267)	European(21550)	ALL(28817)	AFR(7267)	EUR(21550)	ALL(28817)	Ankle-brachial index	HPOID:0003028	Abnormality of the ankles	DOID:341	peripheral vascular disease	D055109	Ankle Brachial Index	EFOID:0003912	ankle brachial index	Vascular disease	NA	Research Support, N.I.H., Extramural
18	60909111	rs4987756	A	G	rs4987756	22361517	0.00000378	NA	NA	NA	21,550 European ancestry; 7,267 African American individuals	African American(7267)	European(21550)	ALL(28817)	AFR(7267)	EUR(21550)	ALL(28817)	Ankle-brachial index	HPOID:0003028	Abnormality of the ankles	DOID:341	peripheral vascular disease	D055109	Ankle Brachial Index	EFOID:0003912	ankle brachial index	Vascular disease	NA	Research Support, N.I.H., Extramural
19	41512841	rs3745274	G	T	rs3745274	22361517	0.0000499	NA	NA	NA	21,550 European ancestry; 7,267 African American individuals	African American(7267)	European(21550)	ALL(28817)	AFR(7267)	EUR(21550)	ALL(28817)	Ankle-brachial index	HPOID:0003028	Abnormality of the ankles	DOID:341	peripheral vascular disease	D055109	Ankle Brachial Index	EFOID:0003912	ankle brachial index	Vascular disease	NA	Research Support, N.I.H., Extramural
21	35823779	rs11088283	G	A	rs11088283	22361517	0.0000488	NA	NA	NA	21,550 European ancestry; 7,267 African American individuals	African American(7267)	European(21550)	ALL(28817)	AFR(7267)	EUR(21550)	ALL(28817)	Ankle-brachial index	HPOID:0003028	Abnormality of the ankles	DOID:341	peripheral vascular disease	D055109	Ankle Brachial Index	EFOID:0003912	ankle brachial index	Vascular disease	NA	Research Support, N.I.H., Extramural
22	23890836	rs131408	T	C	rs131408	25009551	6.00E-06	NA	1.21	[1.11-1.32]	1,641 European ancestry cases; 1,604 European ancestry controls	European(3245)	ALL(3245)	EUR(3245)	ALL(3245)	Peripheral artery disease	HPOID:0004950	Peripheral arterial disease	DOID:341	peripheral vascular disease	D058729	Peripheral Arterial Disease	NA	NA	Vascular disease	rs131408-C	NA	NA	NA

Mapped by lexical matching(Total Items:0)
(Waiting for update.)

Mapped by homologous gene(Total Items:0)
(Waiting for update.)

Chemical(Total Drugs:12)
CUI	ChemicalName	ChemicalID	CasRN	DiseaseName	DiseaseID	DirectEvidence	PubMedIDs
C0085096	bisoprolol	D017298	66722-44-9	peripheral vascular diseases	MESH:D016491	marker/mechanism	2967187
C0085096	enalapril	D004656	75847-73-3	peripheral vascular diseases	MESH:D016491	therapeutic	20847891
C0085096	imipramine	D007099	50-49-7	peripheral vascular diseases	MESH:D016491	marker/mechanism	6859313
C0085096	lidocaine	D008012	137-58-6	peripheral vascular diseases	MESH:D016491	therapeutic	3564823
C0085096	methylphenidate	D008774	113-45-1	peripheral vascular diseases	MESH:D016491	marker/mechanism	18431096
C0085096	methysergide	D008784	361-37-5	peripheral vascular diseases	MESH:D016491	marker/mechanism	1006471
C0085096	metoprolol	D008790	37350-58-6	peripheral vascular diseases	MESH:D016491	marker/mechanism	6961757
C0085096	nicotine	D009538	-	peripheral vascular diseases	MESH:D016491	marker/mechanism	19559087
C0085096	nitroprusside	D009599	15078-28-1	peripheral vascular diseases	MESH:D016491	therapeutic	866660
C0085096	thiopental	D013874	76-75-5	peripheral vascular diseases	MESH:D016491	marker/mechanism	3564823
C0085096	vitamin e	D014810	1406-18-4	peripheral vascular diseases	MESH:D016491	therapeutic	20174656
C0085096	ticlopidine	D013988	55142-85-3	peripheral arterial disease	MESH:D058729	therapeutic	12138688

FDA approved drug and dosage information(Total Drugs:0)
(Waiting for update.)

FDA labeling changes(Total Drugs:0)
(Waiting for update.)